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<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB22</accession>
    <name>A0A9D4PB22_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB22"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="13605" checksum="653E1D78B0EF7B33" modified="2023-05-03" version="1">MRTQAETNEFRKANQVTVRGRGVPTPVLGLHEAYFPECVAEAAYALSYGPLTALQSQCWPVALHGRDLHAIAHTRAAAAPTNPMNRPRPRCARTCSEPRGGRENSTASFGLGEVHRCPFRVPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBY6</accession>
    <name>A0A9D4PBY6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBY6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056094"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="59603" checksum="3A514BB1F73CDE99" modified="2023-05-03" version="1">MEQWRRERLAREALEEQQRQQQLLEQQAVTAIGEWMQEKAKEASPAAPDTTETADSPTAGLEESTTAPLPPASDEDKMDVTAASRKRGREEDTTEQRCNGVPAEAGGETSNSCSSTCRLPPVRDDEPSLTAPPAVLLSHAASAGIVAASPARRKRKSKRKARPKRRLPAREYETPAAEAPTAPRPLNTTVAVPRPCPGPPPAENDFVTVVSKAAQRRARAHEAAAVAIDPAVVGTALFRPSAPGGSFSGSPRLTLAAALAKRPGVWAVRVNHRLNIVAADASTPTCLSELLAIRELGGVPVTAREPADRSSSTGFIYGVEGGLTNAELLAGITSAVPALSATREGASVKLRFAEPLPPERVVLLGLRLRVRHVRPRPRQCQQCGRFGHVPEACQRKGACIRCGRQHLEAESCKPRCVNCGGAHAADIPTCPRWQEERRVATFMAVTPTPLSRRAVKAAVREEFRDVRSYAAAVKNKLLEGNTMDPGLQRPSPAPRRSLLPTASSPRSSLPAEDPRDTLITNLLAALQAVMQSLPEEHPLRATCLQAIGTRSGATGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC51</accession>
    <name>A0A9D4PC51_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC51"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043895"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="79" mass="8507" checksum="484E3604A8386522" modified="2023-05-03" version="1">MSVRRRAKSLGALRGPEQPSSSSQHHQASGASPSGTATVSLIEPDGAPLLPFLFSRMVQDRTALYSSYPSIKCDIVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEH1</accession>
    <name>A0A9D4PEH1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057990"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="568"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="642"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="902" mass="100375" checksum="876161A7700F306D" modified="2023-05-03" version="1">MEDPGNPLSTIDYVHQWLTSIHVSAARTHQDGDYGAAKDVEDVDTSQLLPTVILVGTHRSRLRGNAQARNNTISEKFTQLRDTLRNKAYGRHVLPMYFAVDCCGAEQSPHVAPAATTGGVDGVRRRLRRPRGGPRGPTPQGRARGGYAWTAWLAFERALARLLENGVYFASLYQLEEIGRQEGIENEDGFHSVVHFLHQQGKLVCFSCQHRGTGVGVLDSRWDGIVILRPQWFLDALYKLVGSAPQASKQTCWEDVPKGKKEPASYRISYKQLRSLWSHSTDQLETLVAVLSSLDILVAHYERIPSEMSLGEEEEAFCVVPWLANSLQTRSMALGNSPSSDALVFFIDFAGLLPVVRLLRWCDWREATFVTGFATIPLDRDNDLLLKLHQTPPSQNRGRIQVVIQRTSTMENWMGGIPQPSICEKVVHLIEAEIEALRELWYNRLCFKCFVTCPCKSLPCALHSSKDCQDQNCLHFLPLDECLHRKVVYCDYRRVQTEFVRRHFPYASFHGMRGYSAGLRRASSATAVWDPDQPPLGFSAFGWEERFGPWEEPPWLRDAAKLLESGNTGRDWLALAKRLGYTDKELSRFVEETSPGVALLRDWRESNGATRYCIDVLISCLQQISRHDVARLIQDEMEPESLAPPVFISYQWDAQEVVLNIRQHLEFSGFPCWMDVGQVGGGDSLYGKIYEGISRAKVVLCCLTPRYASSSSCARELSLADVLRKPIVPVMVEPTPWPPPGPLAVVLSALVYVDLCGIGGHGGSGRRADWEMRFQEIVARVAQFLAPPTSAPRPHSNKHRAASLAPLLAQHATASGGPAAGTTNAAASSTNAVRAATPSPRPSFSQANAVRNDDERELQSAASVPMDDDRESDASNPGSPQSWDRPNRVINRVVRCSICAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEV3</accession>
    <name>A0A9D4PEV3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051464"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="191" mass="20736" checksum="BEB92D54F0FB980E" modified="2023-05-03" version="1">MFRSKYLGSRDLLSSRRFVRTSGTLESCEGNGSSPPCDVTSCAARVSAAAHSVDHKVTEVVRTFLCQDMLCPGSSTAGPSHQGLPGRSRGGPRRPGCYRHRPAVRYKIRPGLNPGYRDISPQVSIRYYRGLIVKGREKADGSVTISDVLSDLSQLRPEGNEKQPQMVGPDALKGKDAQHIMGDLQGIDGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFZ9</accession>
    <name>A0A9D4PFZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFZ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="75" mass="8473" checksum="C98FBC5C6539ABDF" modified="2023-05-03" version="1">MTARLKLCFRACAQEMKHTSGTDDSKREENKDTFWEFADAIAETPTSAPAASEAAPPVRRYPVRNRRAPDRYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGK2</accession>
    <name>A0A9D4PGK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043084"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053387"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="907" mass="101203" checksum="FC1516824347F7F0" modified="2023-05-03" version="1">MLRLLRCQSPSSILERNASTVVRALKTRRPGTHPKTYRNLDEIIRFQGFPDTKFCQVGPFLGRLLAPFLPPRRHERQVQRLCARRHRPAAAAVGPESLTCRRTSLELPIPDGNVEGEDIRPEDFGEGAGWCRVKRTKQGDGASESAQDQQAETQQQAAAAEAAREDSICLNVKQNVVVLSTPSADRAKRYGAISKLCIGNREFEANAYQAAPENTYKGLIRNISKDESPEDIVNNLVTQRNPSVLHAKRMGTTDKIIVLFDGFHVPRHVYYGPMLVRCSLYRKHIDVCFACGRLGHRSDVCPNPADKICRGCGSSNPPSDHRCEPRCQLCGKDHLTGDRVCKARYKTPYIVKCRRLERKRREEEQAAAASDSIHNSGISTEGNGGHYNHNPALDSYSSDANRRGRSSSRDAKGGGTGHRDREACPRRAVAPFRAPQLSTKAPNKVSSISRGGSRNNKDPSARGSRAENSKLKGEAPRVQQPQQQAATPPPPTPRSSTPSRPEAAGVDRDDESSLVEGAGGREDRPCLFVLNVYSKPSLQHRFGDLLRRASTAANGAPLLVAGDFNAPHGAWGYTRETLKAKHLWEDSQDQRLELIANPADPTRGGNSVSADTLPDLAFVSNVTAVSWQNTQEDVGSDHSLIEITVDTGASVRGTYSEGTGRRLKLVQWDAFRKKRAEGGRGDEPIADIDEWTATLNRDVDAVTCHIPPEAKLEVIDSRLLHMWEAKQALLKRWKRQRHNRALRKRIAQLDREIQEHAFQVCSAQWEDLCNGLERQMRGASAWYLLRHLLDPEDTRAAQSHQTRRLVTDHKGDDLLGAIRDRYFNTYADDVTLWVPGGCCDGHVERTLQAGVDEVQEYLRVTGLECSATKWELLIYKPTSRGRKTPRDEEREQTAIMVRRYRSGIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHK5</accession>
    <name>A0A9D4PHK5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHK5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="14252" checksum="7D2F90B15E865504" modified="2023-05-03" version="1">MDTRSTRRAASRTDADGPGVGNEAGADGAAETGGQQPSPGGTASSSRDAPVPLLETIRTWLQDLFAFVAPVRDALARTPPTAALPKLDVPTFTGHAAGASITDFLDDLSVYRPVHGLSELQLLQQVLPVALTGIVYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIW9</accession>
    <name>A0A9D4PIW9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051821"/>
    <dbReference type="OrthoDB" id="6507438at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="372" mass="41801" checksum="F863D7D71079FADC" modified="2023-05-03" version="1">MGTGSFTTQMFPRDGLCDYIFYDSIYKSGITTFDPPEEADSGLVSFVEKRKDYSSTDFGIGFSYKYAPYVSSVLSRNQDPNSPFMLGYFWKQQIYNFGVLDTPTRDVKEASVKEAFDLLKIVAGFSDLKRAQGYSCIMVFAALVPNDSWANFYVLEFPAVGPGIFISLGHYDNGDNTFSDCHVMPPTVLSRPAQVAANNSSYEYDLTTAVASLNKLATTGATLVWATSVTMKGRWTVLEEGEQPEFLSRCVHDPSAESFGDVAKVCEDDSFKNTLNDFQVYSTLTYNSSHLFAFDDEDAFKQKLCRLKADHSSLDFGIAVFDLEYEDFSNACDFFNLRGAFSRLKALRHIIDFFRTNFKEPSDRTTCLSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJX3</accession>
    <name>A0A9D4PJX3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_018916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJX3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042687"/>
    <dbReference type="OMA" id="MPFACRV"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19712">
        <property type="entry name" value="bHLH_TS_dimmed_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF167">
        <property type="entry name" value="PROTEIN DIMMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22951" checksum="CEA702E1EFAC6804" modified="2023-05-03" version="1">MVRSRGEDTAAHEEDPLGAEDWPDEARQPDRKRPRADSRSSSNLANDISDGARSDSSSSQGGGATSDSPPPPPTDGATRRRPPPSAAGAAPTGGRRRRSALSARERNLRRLESNERERMRMHSLNDAFQALREVIPHVAMERKLSKIETLTLAKNYIMALTNVICDIRGDPKPYQFCPAELPLHDDEEDDIDEDDLKEDDLSVSDGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK48</accession>
    <name>A0A9D4PK48_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK48"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="80" mass="8790" checksum="9F368F4EBBF724B1" modified="2023-05-03" version="1">MTSQGMAPGQKHQLVCASMPDCKRQHSTESEDESTVIGDHNVANLTDLDMDEGGFRLVRHRKDRTVGIPVLIAPTSEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMN8</accession>
    <name>A0A9D4PMN8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMN8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10741" checksum="175E332FBC1DF54E" modified="2023-05-03" version="1">MERLCLTCFSLEDGANNAAAFWSDFIESLAANTSLTTLAMKPRYITERAIQSLADVLKSSVNIHTVHIDFEESPDRNIFVRALSAGLEETYVLMGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPC0</accession>
    <name>A0A9D4PPC0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053854"/>
    <dbReference type="OMA" id="YTHITQL"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="277" mass="32031" checksum="58222B52E27677B0" modified="2023-05-03" version="1">MASVLAYPKELYDYVWSLRDTRIDAWDSNITRGSFVIPLIISYVYVAKVGGPWWMRDRKPYDVKRGILAYNAFTALANAYFLYRMLPLTLFGGGYSFLCQPIGTDCERDMAVVSLNWWYFVVRLADFLDTMFFVARKKYTHITQLHVSHHALVVLDGWIWLNFGSDGQAVLGTCVNAFVHVIMYTYYFLAALGPRVQKYLWWKKYLTTIQIVQLVVLFVHSSLPLFFECGYPKLLCCVEMAQLVLFIVLFTNFYLKTYRAGGRSGPPLAEKTKEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPN3</accession>
    <name>A0A9D4PPN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPN3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="819" mass="88619" checksum="FF431977331BD91A" modified="2023-05-03" version="1">MPCETIGGVILTKRNDVMGATFTAGIPGPRFSAEGRLEPPVPQRQLSSKYATRPVRRIETTTTRDALRTKEIVVLRRRRRKKAKTLSVRLKQRGSKPPNQRRRRSGNHRPKQAVRRHLRRRQGLATGKARSPAMRRGSGSEDEGVQGNPQVVVAPESQRNERFGELTPERRLEELRAEMEKLSQVISGSARDSELASGRQDRCGELRRYSKRNLSEEALRYVTLQEGRQWVNAPELAASLRTFEEAQGMNSAAKQKVSESQGASVSKLDTQRSSRGGARSPGAETKPKLRGCYACGAAGHQKWNCPMRQQQTPEVSGAKSESLAARVLVGEPGTVPVLCALTDRLTARADCLLSEKAWKSLKEECASERTSKSAEQIDDTQLAPVSGPLPTGKVRKLDVESPVLKAQGEIATMEGVVTQAVARTGDDEGPQGSRASPGETQAAGKKETSASEEVREGEQAGSTLQITGAGQDGIVERHRERSCFVRVPTGPRNLVQVSKLRPRCPRSELKGVFSEEGGAASEVACAPMPATAHSAASSPSYNMSVQVGKRKRSRASEVFGRNGGPLGGGTNGISGRQREDVVRAGFTRKSRYFKGETTGQADQLLKLGECSVTRPSVRDLGRVVGSSCHAPDPEKRAVSKGLSSPAAETEPRDVLGLCGHYLSYGQNYAEVARPPTELTGGRVPNRIPGTAGAEGVSRRHGTALCETASLIRSDLEKPYWLFRNVFAAATEACLSQRAENGAEASVAFERRGFSPTEARETFALSWDPGVQSLALRRIDDRGLWPPPTIIPDANTLSRAPKGRWGYGSGASGADKTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQB6</accession>
    <name>A0A9D4PQB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042459"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12073" checksum="B220FFECF6639B98" modified="2023-05-03" version="1">MHKAAQRGFAPVENYPPIPYSFNYASQDAEGSHTHEQSGDGSGRVTGRYTIQLADGRTRTVTYTADENGYRAEVVTNELGTESKNPADVVFQSSAPTGPEAAIANEPNRIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR55</accession>
    <name>A0A9D4PR55_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="75051" checksum="692FB80BC0C2D292" modified="2023-05-03" version="1">MIAPSRFQPLDQLDEASNSQPADLTIQGPSRPALLSDAPANNPAATGNQVSPHLFAERHALPEHTASGRDTAMEDQESWTVVQNRKLPRPKPPTTPQPQTLFETIMLRPKAFNITQIPPYQFAYRLRLALPQIKGSDIQCRLLTKSNLAVVDCYTEQAAHLLLNLEHLIIDDQIVQFNTYVALREGRIRGVIHRIKGLTEEQLMQGLTSSTHEIVSARPLGMSNTALITFNGTNLPEYVAFESVAAATTALRKRVNKPYKPAAPYSSPHRNASGKVTQKAQQSQEQNFPSLESDHQTLTPQTRTQSATQSPTQLASTATYAARVHNAPSQQNASPAPQTHPSVLQELAELRNTQKKYLQIIRLPKYAKLEDLYGTGLLLPIGDYVEPALQAQNERLKLTRAGRAIRSELGLSNEDLPQILPTIPPWEDITHQSKEQLGDASSEQTATLIQGDTHDANYRAKVHRRRKLRAKLEEATKHDAPPPRSTRPYEVILRKLQTRSFTTIPVLHKMYPTKYPDPNCDYCQAPATTEHILWECPIHESSRAAFIKRAQRTLPHLQQDMEETTHWILEDPLIRARLNIWCNDLRKTAIPDQLEDEAGMLHRCPHMSAFRVIVLTTSCRVHRVKVAPNEEMVPLCDVECSFEEDVEAVFAASGLHAVYVEYEVHVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRS6</accession>
    <name>A0A9D4PRS6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Presenilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRS6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053847"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30291" checksum="F9D3E435B64BA37D" modified="2023-05-03" version="1">MNRSLADKALLLPNLVSDPLARSGEMTSERAGRVSQTASSIRSGLELAADDSQSTSACRENEDSTVSFEGKLRRFSEPNEAMDPPCSSDKVQECRNEFNARTATESMDGKGSTPTRSAANTAVPDDRGVLQVVQPDNYNDAGGAVERQSLQHAALPALPPTPGSHRCPRHGRAHHRRRVNRSQAERELGDEMSGDRGMKMGLGDFIFYSVLVGKASRHGTALTVIACYVAIIVGILLTLSLLVYLQKPLPALPFSIGLGIAAYFSSSFLAEPFIGDVAAIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSR5</accession>
    <name>A0A9D4PSR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GT23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_022182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSR5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033069"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GT23" evidence="4">
        <location>
            <begin position="97"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="3">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7952382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="208" mass="23446" checksum="19FAEFDE77F7E1B9" modified="2023-05-03" version="1">MCEGNDAPDARAVTAALTHIVKEKALPSKDMGIRDENIEEAAVSIPEDVIEELEALREPPRKPPNSVAYSGLVYVGGYIAKLITDVGTKSRRRILDLPVSIAATLVANHADPYAWWYGQIMGYIFRLQDSFRRKIETFKREIGYKHPIVSIHVRRTDKKQEAAYHGVEEYMGQAEEFYSALALRGEAVEKRVFVATDEPDVIDEIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUC0</accession>
    <name>A0A9D4PUC0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030022"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="29606" checksum="73630777AA4042A5" modified="2023-05-03" version="1">MAAQCSATQEARRSITQHAYDVGDTLRGMHAESQRVKDWTVSSGQVCQPANPHERMNLPDDFSLARAGLPVGSAADLIKRLTSYYGLALRSNTDVEDMKKAVMATFHNVSSTDAEPHHELCPSGARSWCRHRAAEAEGKPQLPHTYNLPNKVVEALRPVYQRLFDPQLQARCSGNKTQNAAESLHSVIWSLISKQQHASHFTVEVAVHEAVERKLTNATLAPLPPPCHATGGERVSKCVAFAGAVITPRCMNGGLRNFGTMDSTKQTTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUR3</accession>
    <name>A0A9D4PUR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044178"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="278"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="361" mass="41228" checksum="8AD8D426642E6E46" modified="2023-05-03" version="1">MLKASWTEPEAPEKDRAGDDLWWCVDDSEMGERGICWEDFIAADDDAHTEELCTDEAIVKEVRGKSDSEKSDDDSEILEPARLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQKKLKIIAVAEESGNSEAGRRYDVDESCVWQWRKDGLQASHRNRRSFRGPKTGAYPEQEVQLGKFIEEVRSRGHAISTKVAQVEVRRLSRELGLPHHFWSRGWQTTLCQCLLASYEEKLLSAAGHNDREDGQQFGELYCSSVSVLTGGNTKLHCTVLLCALTGGTKLRPYAILKRKTLSKVSLPAGVVVRAHKNAWMNSGFFVDWIKTVWDKRPSAMLACRSMLIRDSFLATQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX35</accession>
    <name>A0A9D4PX35_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX35"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19546" checksum="7BA316733366DAD6" modified="2023-05-03" version="1">MKEIVAGTEITPEEFEASEWLTQVNKSREARTSKGTTIPPASDTQDGRSTSHKTSNASNDDTAATDRSLTPRQPNFPKSSVRGEDLIQVNPKQNTFAYCTPSVERAERVLRLKELVIGTHTYEISVYCAPDESQGCGVIRGVDLRLDRQGIQEELEDPRNPPIVDFRLWGTPPPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXL8</accession>
    <name>A0A9D4PXL8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039715"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046010"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="391"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="27"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="195"/>
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        <location>
            <begin position="998"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH7957625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113806" checksum="722189AF4AB57214" modified="2023-05-03" version="1">MPPRLPPRPPPGRGPFPRGPPPRGISPGRGGRGSPGRGTPGRASPGRGAPTPPPGAAAPPTPPPPTPTPPPAPESPQKKMFEDLMAKKLAEWDRMMGSGKDEERAQSFDMFRKLSDEEVDLANRTVSKNRLKEFVDLQIQYFDQLAGQNNPKVRSEGLKKFQQVCEKELALAKAVGPKEALLEESESDSALAKKRKEDQAKKEDEEKKKKEEEEEKNRKEEEEKKKKEDEEKKKKEDEEARKLSDAQALYGMHAMSGMMPRMMPGMHVPGMPLTMTPEQMRAMMMASQAASTSCTFAMQQRFDTPTGTMTTGMHDVIGPVTEGSHFGKEHKPLTAEQFKGLYNADSALQFHQKPGHFPSRLPSRPPSKSSMADVRKEETDKDTETPVSDIDKKLQLLSQLESARGVLQKHCSPGSSTSMAEEVKNRLRKINRLQMKVIDEILGSKVDLTSEIVSDLRPEKYEREKFDDLRKEGGAVVDVKEKKGKKGKRSKEPKKIVVELPEYSEPNTHVVTASISRFDAQGVCTGTTDLCPGPQESRPEVIWERPRSETRAPDRMSMAGPPRDAIADYGPPPDIGPRCIHYEQHIQLITDNVPHYHEEMMPPEEDMYYQQPAIPAPTYSVLQSQCFTPPPCLPLEFDINLSFLREVSDVGVEAEEEEPDDEEDERSLDLPLDPPPSKPRMLSQTTIIVNRPEQGVQTEIAQPPPAEPLQPTQPPQPVPPQPMQKAPEPPRPPSPQIHVQAVEVKQSSSNDKRFAKSCEESLQRIADSVDDILQSLSSLSSDYAQGAVRQHQDHYDDDSYDDSYDEYDDLSESDDPPPRRQMQRSRGRRRTSGCDDGPSLWGWLCRGVRAIREGSPSRPNQNGSHTVQVANRIRELVQRVIQASNEVIMARKAIQQGGLQGEIAMQNVFEAENKLWQLINLESQLANELAQYRTLDTTSNKAYFDSIIQAEDKIRRLIQVETQLANEIGAWRQLSSQMPQSTSYTRTTMYRVPGTAYSTSSATPTGLLSPSTSSTGYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXY4</accession>
    <name>A0A9D4PXY4_RHISA</name>
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        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">HPB52_022543</name>
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    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXY4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957746.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43045" checksum="0D48690390463E63" modified="2023-05-03" version="1">MPPPKEHFFNIRTPPGTSVGEAIDAMEALVAIEEIYSVQHHGGFDFQAGVNSIQAAQDLLETGCLRLGTRVDPLVPVARQVASVTCLYLLCYVPDNEVATSLKSFGTTLRKEKARYKDRNSLRMGARYISWRIHSRILHEWAARPTFEYRGRSVPALRRRPRQRRLHRKKNMWYDSGDGRGRVSDTSHGAPYRADTKETNYPATGKANQAERRQRRAGTARHSRKKRQCKPRHWRGRKEEGKEGFTDPDIDPEDIRTRRSKCRRRRAKWQCFRLGFLNLHGARRKQKWGELYNALREEEFSVYAVAETHLRDLEEPPIQPDWHWTGQNRCGQSRKGGGSFTQASVDGHLDANGKLLLQLAEDLDLVIVNLGPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYM6</accession>
    <name>A0A9D4PYM6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005184</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
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            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYM6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049113"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="356"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="547" mass="60640" checksum="5FAD327D35434EB5" modified="2023-05-03" version="1">MVVLCLVYSRPVRPDSRPRRLRHCHFVVSDEEDATGKVVVRTRALSHESCANHSPHWCSPATVVDLGRRSGAGNHHTLDAAEDRCGEQEWRFSSVGHEVLTVSPLMDQPFLFSSGDHGTLASASQLQPALPSAAPPPPRSPTLAVTGLLKVVHWLSQRRKSARPDAGKQHGRSRLADERLARKKLKVLSSHQPAAATPPCTCHTRKASFAAGILSPNGSLSSSGYISSSASSAVQTPSDTELDCRGARAHEPCRLHPTRGAGLVRQNAVISEHGRSGRQWLANKARTLSLETKANDVEKLCATWPPLGRSAGNPAENFLEEPESGIEESEQEDKSKNQSTNIKDTLGEWCVPYKDVEFKERLRQGRDTDVYRGRWHGEVLIYTFRHTKEQDVTRFWDEVGKLSMIRHENIALFMGACAEPPQYAIITSMKKGPSLFEHIHIKKHHLSFHTKVNIARQIVQGMGYLHAKGIVHKSLTSKNVVLESRVKLCLMDQGLAERVHDPSDRGCLARGHLTYLAPELMRQLKVEPPNVFSDCEPSQESDLYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYN4</accession>
    <name>A0A9D4PYN4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYN4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="12255" checksum="2CE00AF76C6576B4" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAERQTGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYZ8</accession>
    <name>A0A9D4PYZ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9803" checksum="6F9763D0EF8695AA" modified="2023-05-03" version="1">MKANVQYNGYHLCSYYFTECAYADLARTRQLLTAVPAFAVEEVSLIDEATEATLDRLLGTCPGLHKAPTSHLRGLDYLSVVKAAVDHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZT8</accession>
    <name>A0A9D4PZT8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZT8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052296"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="440" mass="48085" checksum="8F38C8C9F802CA7D" modified="2023-05-03" version="1">MKTLPKRAVGHKELSTMGSFQTSRTNVREVVDEAVASRAEALHAVGRFLWENPEIRFEEHKAHDTLCNFLEGEGFDVRRHYFLETAFRAEYGEGSPVVAFLCEYDALPGLGHACGHNLIAESAITAAVAAKELIFRRNELSDAPVKGKIVVLGTPAEEGGMGKELLLRAGAMDDVDAALMAHPENRSVLRMRLSSRSGLTMVFDSVDVPDSEQQPSAMDAAVLAYSNMTLLRARMDPDSRIHGILSTETTASFNVRRSRLDMNVRSPSTERVLQMRRDVEACAEAAAKATGYTTQIDITRRRSPTKCCTPVARNPCSSPPGPFVVCLLSETVRDGEEEASRREPSHTRTPFADGPMTTGATSDAGNVSQRLPTIHPVYGIESTGFNHTTEFCRVAGTRKAQETALLIGKMLALTAFDLLCDPHLLECVKKEFDAFAAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZY4</accession>
    <name>A0A9D4PZY4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_013881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028245"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="5"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42296" checksum="E2CA3FECBF346467" modified="2023-05-03" version="1">MLVHEAPGNVGLLDQALAIRWVHRYIHHFGGDNQRITLLGQDAGATSIGYHLARNDTPPIQRAILMSGSPFVPQPDNAGQRALLNGHALADVLGCGSRRSLQDASQRQRVVECLRKRSAYATVLAADELATSSDTVVFGPSKNRDFPWKLAGAVLSKAMLQRVDFLVGVSKDEGTSHVSELMQAFGLSADQTLTPRRLLSMFLAFLESYGIQDVESVLHHYGFDEPSVLDETLGLLFLLELARPVGDFLIYCPTLFFLEEAASVGGRAFFYELAYSPSYRTWPAWQGVPQFVDLVLATGLLAELDASARDMAIARDFSRMIAGFVRSGNPNALPNMMWHRWEPSSDGALILDYDVDSAYKQAPSFPEKANCDFWRRHFTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZZ2</accession>
    <name>A0A9D4PZZ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZZ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032965"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15188" checksum="E7F5605FA4C26989" modified="2023-05-03" version="1">MPEGGNDENEDGEDTEDCESLLAEVLERQGEGVEKLNFGTFRDVDGDVVTSPNFSDSDIVAAVAPRPDSSESEEESDVEVDDGPSLSEAARAVTVMRAFAEKRGLMDRLAHGLTDFEDAVVAARPPRRQVKITDFFAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3J7</accession>
    <name>A0A9D4Q3J7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_022452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3J7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044163"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052105"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="4">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7963714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1185" mass="129658" checksum="91EBCDF0120BB92D" modified="2023-05-03" version="1">MRLVVEDLGSDFIQLLVDIAYHIPLHDLVGPHNVADVLDLSEKLKLSQLRSHCVEVLERNVQPESCIGSYHLASRRSYDYVTTKAFCYLVRNFDQVWKKNTEFEALTPEELHTILEDDRVHAPSQVEDTFNALLKWIHADVAARKGYLAHIPDFEKVITNTAINGGGNCLKVLDVIYQSTTRKSMAASNSKGHHLRLRRMGDGATSNMLTYNCRTEKWRDMGNQCTTCRSYHGMTVIGQRIYVLGGFNGCECHRTVVCFDVVLGRWSYKAHMGRARCYVSVAVLKGYIYAMGGFDGRRRTRTVDRYSVKNDQWTNVANMNYMRSDASAAAAYGRIYIADGFTGRRFLDTVECYDPLTKVWTLVKSMPWLSSGHKLIAHDDMIYYMGGSNNNGGIFFVTQYDEAAPGASCALDGSLARRSRSHGTISMGHGLTSCGTWSLKVPGLPRTRRREPRGAFSAFLADFEFGPGIAQGVCAGLEGPTHYDDQEANTRSVLVGNAVPVPASTPADPDEFSLEGDDVLGRLQSLADDADPARAAASSRNDPGDPGEEDDAASSVSDATAVVPGLATDIGSRVQRRAREIEDELSRYMSESSNKVPVSARNFIMSRVFELVASCADLSAEAASERGAALALRGQLIEARREMATMQRADPGASSGSGAIPGRVAGPCYSGMPGAPSAMPPGVRSYAAALTGSAEHRPRRRPRCQEHQHDVLRLLKTNIDPASNGIADVTLRHTRNGLTVFTNTSDTVQNMVRAIQENSVARIHRRPRPRGGGPRKLSKAYRTAAGQVTLGWTAVRVTEDLHVPTCTFCAAYGHGRNSCPHKTDPTKATCMKCGGNHLALACSVMIGDPVVCCAECQRVRRPAEVHPAGGEGGAHSSAHGLRPPPVKQGGRPSARRRRTWTRHLREIGGRPEMGASVWTHPDLLGAIHTAIRFVQINLDHARLASANLTDAMREGGITLALVSAPYRPGNKLPKPPPGFQYIAADNDSAAALLVARAPFDLCPLLVTPTVVAVYCEARDQDFMLILIYAPPHKPMEPILVSIEDAMRASRTRNIIVAGDFNAKHSAWAHQHTDARGSRVVPFAAAHGLGGRLRPEQKVKIYRSVILPAITYASPIWWDENCPDRRLKARVIASSGQVHARTSEQRKNREFCDIAFRALDGSEIWAHRFVTAARYSGCHALFAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4D8</accession>
    <name>A0A9D4Q4D8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4D8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035489"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="296" mass="32983" checksum="C1638EFEBA400E17" modified="2023-05-03" version="1">MKDPMYFENYGEPLEFEAPEKVEKALVPNYIRHHGTGTCAVVARVAAASFRGSKSHRKQLLTGATLLRDEIVPLGGWADEWHALMPRPRPIVCFLNWEGFLSGPVEMVSDDNSGDEDLDVFFVDLPPPDTLVLRHFPGFYCSEIVYDGVVFENATLELLADATDDAILGQLKRIRDALFPHWKLIVNVFMKGFSEKRMYENSPVLLGSLFTWLEGRRVDGINFELDGNALLGDDGAAVDVVAFFTSVYVDHSRGNLTLSAMLPRGAATLFHEDLPSMLDRIIIKTHGLLDEPLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4V5</accession>
    <name>A0A9D4Q4V5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4V5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11701" checksum="571D2924B41515AB" modified="2023-05-03" version="1">MPVVEELTFEICDVHRRNLSYCNRAVKYAMNPEKFGTQRVPAAVFETLCHKESFKKLLSKVLGPDGAVEAVRKASRHITENLLAMTGVVSQFPVTCWPHPEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4Z8</accession>
    <name>A0A9D4Q4Z8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4Z8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7968185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="381" mass="41952" checksum="3E01FED3496E7038" modified="2023-05-03" version="1">MEVEGGPLTSEEFSKDSGWQTVAARGSRAKSAPVERAGAISTGANPNDDVAAQGRRDRGRAKAKIIFRVRREDHCQASSRVGPTVVAEAIWNAVGIDSVTRYSDTMCPNFQQNIMVVSTPSRENATRYVKVECIAIGGQQHEVNAYEAAPHSTCKGVIRGIAPSDGPEELDCKIVTSKNPQAMGDERIKNTGTVVVVFDGYKVPNYVSYGGTLVRCALYRKQVEVCYACGRLGHRADVCSCPDEAVCRGCGIAKLDEQHKCRLCGGRHLTAAKECQVPDTVPRQTQTRRAIPGQQKQVSGLRLGRPTVPGPRRSLRESLSADYRWAFRTPFQAQKEIQIQGHIRTQGKVQEPFPEPLRLQDPIRFQRRPAEEDEVEPNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5E0</accession>
    <name>A0A9D4Q5E0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5E0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19214" checksum="80743D12A6CADEE9" modified="2023-05-03" version="1">MPLPLLDKTGNFGWQPDIRTLASSASSDAVLNVHRDGIPLGHDTCSGMEHSPFLLFQASVDVELSQLSARIRSIEVDMTELRCTEPSASERTGGLVSRDISEKLKAIESRCDNEEKCMCRSNLPFFGIEDDSSDTWSSAENKVLEMCSERLGITIDLAKIERAHRMGKYSSGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5H1</accession>
    <name>A0A9D4Q5H1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5H1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="373" mass="41423" checksum="C629CA09FB6A10F1" modified="2023-05-03" version="1">MALELQRFHAFLFMETAYVTSLDFVYAVPAAVVGPGPTQLAAILPLRLWLCATVAALGVAVVTTILRIAPHEKPARRMAQLISESLSLALGLVALCFGQPLGWRDDILLNSHQDTLDLPPVGLDSLKYGRRQRLLATCRTRKFNERITHSRRCATRLLLSVWLLSVVALLTAVQSCLISRLRTPPAPSALDSTERLREALVQGLVLPCLVGKTGSAEYIIQSHIEEQDGVNVPRAQSDSLVTFFGAPVAAVGWPHADHMHWLSSRIFETGLVQWHERLIDARNVSASRRMRRMRHLSHEDSSVLEDLRVGPLNLLRFAIAFSALLCGCTAAAVVAWCERIHRWTHQWQRRCACASEIRGQAHCLLAHPDDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5Y3</accession>
    <name>A0A9D4Q5Y3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5Y3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054774"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="653" mass="74335" checksum="A6B0C8059822D353" modified="2023-05-03" version="1">MASTTAAATVPVPPRQASDFVGLFPLDLWRRIFTYLDATSLLAVAEASPKLKRLAFCSKILKRLTFDPETDERIVKKFVLATREQLVDGDRVQDVPLAPHVLRLRLNNCLAFPSASILDIARYCHNLQELSCVNCVVEPIALFDLLALKLTGVKKLEWSLYEDSHYKTWLDKRTVTHLRTFPRLQGPKLNTMYVELAVTDETVYFLDNFVAQCRRLRHLHVHAVRKEDPDVPGSEACRRELTKRKRHLETFKYSHEELLTPMNLGTRMMERDMRRRTYSAEDAVWGNVDCRFKPEEATNLFTFADVIERKVILRGIKQAVVVVEGDARSTCLFEHAAGQADLWKDISRLSLALMPPRGFEVPTSPTAHRGYMNPMMQFFDACVSRLVELNMTAFHFTEEADCCLVVASTLPNLRSLALAPCGVNHAHSLESLACGCRFLEHLDVGSDGALSCEACHRPLLFTARRIWMLHETTRLRRLSIGETATVADLTFLQLCRVVELRLNVDCEDAAKLRDCTCTLGELLRSNPLLTSLTLVAGRETLGARFAENLSAVRSLQHLCVLTATRTAEREAEDFFMILEDRLPQLRSLHAHYLDVRGTVQVRTWLRQWRPDYTPPTIAKWRSSEGVFLHDRPCLGRLCSVSTFIGLVRPRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6Y6</accession>
    <name>A0A9D4Q6Y6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6Y6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7969201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12521" checksum="E4474B5B09AEEAE4" modified="2023-05-03" version="1">MQAGDPQCSASSASINAASFDERSYSNRSPRLRAPPPTPTYVESSYAPRSSYSYDSQPPSFVSEWQQFPEYPHHAAAFSVPRERPVCYQCGVRGHIARFCPSRPTPLHFPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6Z7</accession>
    <name>A0A9D4Q6Z7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_014708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6Z7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050392"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7969112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="504" mass="54754" checksum="E8006349CE03016D" modified="2023-05-03" version="1">MRMRLEHFVVAAGVALTAVRLAMVAQSLTVVAVLIILLLLLRWQQSEAPDFNQRPHADSGLWLSLLLPFALLTAGNSYEHGDVYTFAEVVCSQALVLSLAVVFRITNIFVYSLSSIWTTTLLVAATGVSFLWSAAAAVTTAGTFSYLVTSLPAYSPKSFTHGELLLVCQGITTFVVVAGCSLACKIVYRDNCDLKCSASAGFLQAGLFSLAVFVVAVTKIQALRRPTWFYASLFAAAVLIVYPLCFAMVNAEPVSWLAYHCFSSYKRLCLMVSWVILLVMAGLFVYWYTTNYSESSTVVRKVFHAAIVSVFLPGVILDPDLMYLACGATLGVFVLLEVFRTLSIPPVGPHVQSAFAMFVDEKDAGAFILTPAYLFIGCATALLLFPGQLGEPGKMPILLSGTVVLGIGDTAASVVGSKLGKHQWPGTSKTAEGTVAAIVAQFAFYFPLLFVAVPTVLPALLRVLHSWPLEKLDGTRLNKQGLQLIMHMNTMYSWLLNCIIYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q747</accession>
    <name>A0A9D4Q747_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q747"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21500" checksum="0F613894665463D2" modified="2023-05-03" version="1">MLARARARREGMREHDLHRLIDTFVISRPTYSLHYTHLLKSERDKIDVLIRRAYRTALGLPPTRQRNASSAWGYTVPSTSWLKLTVPLKCNAFVFGRLVAGSSLPLATVPLYTHRTTVGRSSSSCHYPITCSRVNVTPAVKFASPYFVTNTPTTQPSFEWTRLVTPRTATPWPSPASRPPHRWLRSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q749</accession>
    <name>A0A9D4Q749_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q749"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22800" checksum="074121E3B689CA76" modified="2023-05-03" version="1">MFCHWLDGYPHLMDMGEESARLCDRRAGDRQTNIVTEALWNNVRRNLPKKKKEPPNGSLLLLGGATVDERRQSILTLGPKLCVEPRLDIVDRLSLTRDVARHVPEKEKDRCVVECVDVVAQAPVARLQDAGYSVSVLQANGSRLLRKLKQKNEPSSEKGRQAILVLFYIRDAFERGTMALDDLTVESGECPPVPPEFAERWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7Y9</accession>
    <name>A0A9D4Q7Y9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7Y9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033429"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="472"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="706" mass="78456" checksum="A022C87795700557" modified="2023-05-03" version="1">MDIPFKQQLLNLLSVNVTQVKTPDHHGVPSQPLPSDERTKECPRRKPKYRRLPPLPRDDFKVIVRPHQGLRIKSLTSPTLADAVITACGGLITGEQFLLRIKPGSNIFIISTPHQEVAEKVSRIASLVVNGRPHAVNAYVATGEGATRGVIHGLQPHTPSEEIKANLRVRTQGVEVLQARMLGDTKTAVITFYGGHVPRFVYYRGGELPCYPYKNTTQVCKVCYHVGHRSDVCPQPDTPVCRICGMRDPVPSHECSPKCATCGEDHLTGDRTCKKRLKPLRRKRSKTSNTSTSHLPRGPGSTMTKKQLRWFSSEAEDLDVDWPGLPPASDSPRSKYQPLQGRSQSQSRSRSWSRSRSRSHTGSPSKPQQDPASHSSKGHKARAPGYPRSPRPEEVRRADAASPTAPSTNNPEYQRIVAENKLLRESLAEIKKELASLKAHQRQTPQKQLRHPVGHVSCQNEMSSGSPEYDLLSCGFDEGNLCRWSGEGLHGPLTWPFGLPQGFSLGPDQAPENGEGGSIYADGATMAHYTNIMRLTSSVVGSQTEAGCFSFWYRMFAGRDTQLELRLQTAISKFAVLFEHSDRTTVDRWDKVRLTVFLKAKFNKAAVQVKNKSQVIWKKHPSSDWMLAQVQFVEKKNFRVATQYSEDLKEGTEWTELTVLLKRGSNCQLGVTSRDAVTTNGIPRATSSINDIPSTADTTAVCLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8V4</accession>
    <name>A0A9D4Q8V4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8V4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055167"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="204" mass="23080" checksum="78B0E1A3A2B70128" modified="2023-05-03" version="1">MEQSASRAEAPAAPVDDGGADRSAKKDLDYARSFSKAPATCQSMPRSDDARPEARTITAGERYLYALNLHKNCPILMPLKIIVKHLEDLEDEFEKAHLDFQMPCTMTDAERCWLSDNVRTFNQILVRAKIETVEIEPGRLFIRTFHLGALLVQHQAPRSTYALLRACILLDLLLKGQRCIHELCLDPDYCGHVVREDAQRLGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9V0</accession>
    <name>A0A9D4Q9V0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9V0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043452"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="5">
        <location>
            <begin position="434"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7971944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="624" mass="68810" checksum="88E08741D9802F77" modified="2023-05-03" version="1">MKTPEEGGAPDGNLDLSTKLGVTAAELTTTTKHHKRHKKRSKRHRLAGQAFATGESCLQNLSDATAMKTPGEGGAQERILEASPKLGVTTAESTATTKHHKRRKKPSVKHQLSGEASPKGEKSEDPAIASSVRKSSPPLDAPPGVPQKGLHGAPSPPQFTSAPVKAPVTPPRSPSMESCALTFLSESPEPGAPSPGSMTLPPTPSALGRTGIRLSLVAPVVFPVPEGRRLSVDPSWPAYPSFPSLDPSRTPTEMCAAVEGAVKDPAVNGAHKKNGMLTASFESTQLFIDDGRQREFAPGAAARAMPGLREQRKTRQFCDVVFRATDDSEIWAHRFVMSAKYSGCYKLFTLAKESMAPERRKEVGCTSCVTDLYSGCYKLFTLAKESMAPERRKEFLEAEEEETPERLILFTTQLIQIRDHCLKTLKQDLEPENCIETYHLATSRGYDYLAGEALRYMVRKFDEVWKISAQFEALTPEEMRSILEDDRLNAPSEMDETFKAILKWIAADAAARKEYLAKFLPLVRFVRCSVIEFEKVVAHPEVQGDEDSLKVLNVIHQTLTRHSMEVGKVAGIDLSPKQWLTPRLPKDILFVFGGWTSGATNNMHTYNSRAQKWHVMGSQYTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAU9</accession>
    <name>A0A9D4QAU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040301"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="256" mass="29154" checksum="034C12DFBEF77EAC" modified="2023-05-03" version="1">MKLLDIYLGSLYVEYNGKIYKQMDGICKGSCLAPILSDLFLAVGDRKVHKQFQGSNVVKRFRYVCDFLVCLDQPLDRISATAIVKMFEESHKGLQFTHEVPTESALQYLDLNIKQERSHMCYMYRTTGEKGMLRFDSAHTKIVKRAIVNASMTESVRRSCAHRCNESLNLQIQRLRESGIPDSVLVSVGENMLKEMKRKKSKEPTKQEKNAAVVPYIHKASHQLKKIGARHELNVVFSAPAKLKGMCQKVNDLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBG5</accession>
    <name>A0A9D4QBG5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_016622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ena/VASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBG5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033112"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000047">
        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="WH1" evidence="11">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7972747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="466" mass="49268" checksum="D813333087477328" modified="2023-05-03" version="1">MPSSFDKFLQGRVKSLISSYEQSVASARAAVLVYDDHNKKWVPSGSSSGLSKVHIYQHTVNGTFRIVGRKLHDHEVVINCAILKGLKYSQATGTFHQWRDNRTVYGLNFSSKDDADNFAVAMLRAIDMLNQNSSTGPRVQQAPPPVPQHASQPIYQTIGSVAQQEDTDHQRNWQNQQPVHYMATNAMGSSSHPATPASGPPQAPPPPQAPPQMPQQTQPNAVMGHHRTSSAPGTNGGAPPPPPPGGTSGMSVAVGAVGAGGPPPAPAPPPSGGVTSGGAPPPPPPPPPPGSSQGREDDSAPLSLATALANAKLKKTSNKIYEGTDTLKKSQGSGGVPMMGMASMMDEMRGTLAKRRAQAENSHSQEAESSTDSRRTWDKQGSTNGNSPSKVAGSGAESPKSGRGQRIGSLGDTDVMKVNGVDVLDMDKLKQEIMSEIRREVSKMKQEIIEDYLVLCHCIILLAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBQ7</accession>
    <name>A0A9D4QBQ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactosylceramide sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_001781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBQ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035520"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7975452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24120" checksum="B5C9CE29FEA3B7D4" modified="2023-05-03" version="1">MHKCASSSVQNVFMRYGETHNMTFALPARGNLMGYPRIFERSMAAVGKPPFDILAHHTRFNESEMRAVLKPNVVFITIVREPAALFESLYSYFNYEASTASELIASFHLKLEQIPNAVRNDSQRRILRGFFPGPHRGWLGFDQMSFDLGFDFTQAGNASAVDAFLEHVDAVFDLVMVVERLNESLVLLRDLLCWEMDDVVMFKINARTVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDP8</accession>
    <name>A0A9D4QDP8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDP8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038444"/>
    <dbReference type="OMA" id="ASCRCDF"/>
    <dbReference type="OrthoDB" id="6492321at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31678" checksum="3B285D6B934582E0" modified="2023-05-03" version="1">MSSNPAAHFDPVAAEIAIVRALDELCARRSNVTMHRARIEELRRDIAHLRECVDAEKHRLRVTEQRMSERRSVLRREAEQRRRPMLAEKETLTQHIGSAECKLSGAIGRARSLETEELTLEGKVKDLRDQKRHLEEVLRQRSAQLNHVTMASRPVLEEFRKLVTLQDAVQASLFDVLRRRVALERERRERVKQESGLASECASLKKALESVTSSLDEVQQAGAEAGHVGHTQNRWYKSLMDKLEGDVAACQRDLESLRHAIGCGTATDVALQTTLDVPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEF2</accession>
    <name>A0A9D4QEF2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase PDZRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEF2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038084"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66677" checksum="4A1C0B971CFE4A3D" modified="2023-05-03" version="1">MRRIKVNGRDVSNASHEEAVAAFRAASEPIVVEVLRRERRNGTGSSSSDFGGSGSSCAGGRAAKQAVVPSPSGLSQGYIDAAAQTEFPWWAPPPWEGSLLPNGLSIPPPPLSPPSRNEDQDDDDGYDIEYEEVTLIRNGNEKLGLTLCYGDPDEQETEIYVGEVNGTDVLGRDQAIVLFSEQRPDFTLLVARTHVSEEDEDEDGNEKDAATTPSKADALLQTSFQEELSETETQVGTPLPDNDLEMSVLANEFQRVILDKKAASVEQWLHQGSSGLPTSPQKWDAADSGSSAYHTGGSSSASPPTLELGGRSGSLLSLAGAPVSTPVYPSLPPMTRTGTAVVSSGHGMGPTEDKSTQLRDSDMQSLTSCESCRCHLDFATSPRRLPKTVSEPACVRRGSSVPDYASLYPTMYTNKQNLQHTMWLQQHLFREALARRNGRVHATKTSSSSVVAASTSTKKDQLVYATTGGGEQPGGDETDLKSQWKVKRRADGTRYITRRPARTKLLKEREQKILEERSGLTTDDDNHSELKTGKYWTKEERKRHLEKARDRKKKEMMLKLKMAILKEAHEGSGTKKSTTSAASRKKREVSPSPESLVGVVGDKAFGLLAVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFQ8</accession>
    <name>A0A9D4QFQ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038556"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="500" mass="52316" checksum="17590C6D278F0BBC" modified="2023-05-03" version="1">MWSSMRAASRPHGGVSGTTRVPPPQGYQHARVSPTASLDHRLPQRASNHVQLRAKHDGTVASPRSPSSKSSGSGRIWHAKTGANEALRARRSSSTEDPDQCGAPSSSPSATTRQAPSVSPSSSPLHAAPGGSSAAGSSCAGSSSLYGEDDDDRRGAAETIPLRSLRRSRSARQPSTTTSSGSPAFGARASFQPDFYFCQPHTSGEEEDGAIGRAPTPPPRRGLVGAVRAGSFRLPCLSKQDSHERPILSCSSSSHDTPPLFRPGSSGLLRAGTEPSSSSSLHPTMHRIAASLRQAPLPAMAVAGLAPGSPPALLRGSSPPPGRFLHRASYHGSSRGSPGLDQNHLTSGAPRRPEDSPSAFVGSAENLVGRVLHEQGLGKYCDADFVRATQRELAEAFNLTQEEMDRAAHEILQAERRRSMPQLHRPGHGGADDYAATTSPTEENAATHVELPVVATSPTENRSPPAEQRADVAASSPTQPQTPGQPSANGKTGGFRDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH08</accession>
    <name>A0A9D4QH08_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH08"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037617"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039937">
        <property type="entry name" value="SNX20/SNX21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939:SF11">
        <property type="entry name" value="LD12265P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939">
        <property type="entry name" value="SORTING NEXIN 20, 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7982707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="246" mass="27517" checksum="9BF6532D18DAAEDA" modified="2023-05-03" version="1">MLVRRSDSASRVMCYTVLVKKSPGLERLPGVLERRYSDFSALFAGLRRRHPSCVALRDFPFPRKALLGNFTSEVITERSLAFRHLLSRVHASPELRRSPEFAEFTWRREVCRAHRLMTAGHCGMYAECSETGEFHAGLLGDGDPDTFTTLAVLTACLNAVDNVAEAQKYAELALSKRLPGSSASNPSDLEVPLLVLAIRLWWAVGKEKRELEERLRQVKDTGINVDALPTLLELVLKKDSATLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHE0</accession>
    <name>A0A9D4QHE0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHE0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="284" mass="30976" checksum="176744239207B57C" modified="2023-05-03" version="1">MALNAATDQQYHLLDQDGTADDQMDQLQGDHDTVSRDAIGAQSHAEEDASWQAAKSTKKRKQEALERRRGSAGPQDQVKTGTSTFKKLPKLPPLPKDDYKIVIRPNQGLPLRNILTPTLAQAIIEACQAGIRDDQFILRINPGSNIAILSTKYEEVADKVRLIRTLVLNGRAHAVRAYAANGDDTLRGVIHGVPMNTSTETLMAHLRVRTHGVEIITARMIGTTKSAAVTFSVQRYLVPSTITGVNSAATPSALRFRSARSAEKKDTARTFARIRIAPFAGCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMI9</accession>
    <name>A0A9D4SMI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041504"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35607" checksum="CBE097E9A5542538" modified="2023-05-03" version="1">MENPCVQISPVTITGTVTVEHLQSNGAPARKVTHQNAEAALYRNEFRDILLRARLGPRSVVYSLQNAVVHKKFVREGVGTGTATVEVMMQRAMRPPWVNHWRRCKVLVVDEVSMLDGRFFHKLERVARLVRRNDRPFGGIQLVLCGDFLQLPPCINITLELKQVHRQSDPRFISLLQQVRVGSCPDWVEEVLKKTASRCLDTGDIVATRLSTHTDDVDFINQRCFDQLPSTPRIFKAIDSEGASADLLEVCAPSTLSLKVGTQVMLTKNTQVKAGLANGSRGVVVGFDSASGDPIVQFMNSCKQTITKERWAIRTGAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMW8</accession>
    <name>A0A9D4SMW8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-stranded RNA-specific adenosine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMW8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045728"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19902">
        <property type="entry name" value="DSRM_DRADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Z-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Z-binding" evidence="5">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="511"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="6">
        <location>
            <begin position="650"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7934845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="102385" checksum="49F1BFECAD0D0CB8" modified="2023-05-03" version="1">MVDVWDVRTQLLNYFHSHPGENVRTVDLCRVIKQPKKTINSVLYRLQRDGVLQKVVESPPTWREAGSAGSRIEQQYSIGYPNDGAAADGWHKLRGHSDENSTGKPLAITDGRSPPPPFPTGATDVSDVLVNEDEQQQGPVRLPESSPPPNLPPNLVVTRGGGRFAAPPSLAPQQLGGAPLPPQQQSPQQPQQPPLGSALVAPVPNNSLVPCANSLLPVAPNSVAVTTANNAALAVAQPAAGPPAAAAAASNNILQTDLTALVISHLRTIGTPVYTKDMVKALGLKHKREVNPILYRLQDRGVLTKVWDTPPAWTLVPGSYGDLERNNLFAAAAAAAAASKQQASPRDAGAPPDFGGDDENAVAAGPNGVGGPRGGPKGPPKPARQPLPPHELLRLSNTFAQMMMQQQAAAAAAGMAAANGGVMPPQASPASVAAAAANLKITQSVVSQSLEVSYGQQQQQQQQSNNGTDAGTNGPVREEAPAAAPTPAPPSNPPGPQSISKFPSYASLTKNPVSAFHEFGQMQHVEAKIDIVATDGPPHNPRFKAVAFLDKKPVAEAWDKTKKEAKHQAAELAFRKLVASGALASDVPSPETDILSSQDESIPMFDIIAALSHREFSQKVLEVPEYVGGRKVLAALVMKTGPTDRGTVVCFGTGSRCITGEQLSQDGTVVNDSHAEVITRRSFLRFLYQQLKSYGPGKEHAILEPTEDGQRIRIKPDVSFHLYISTAPCGDGALFAHTTKPDDKNKTQDQNSEQHHPLFTKSCQGLLRTKLEAGEGTVPVDLTTDYQTWDAILQGERLRTMSCSDKIARWNVLGLQGALLSHFLQPVYLSSITLGNLYHHGHLSRAVCCRLEGEPGLDTLLPTRYTLHHPTLGCVSGHNPPRDTEKTKPYSINWCVGDERPEVTNSGTGMRQDSTTTNKEELVQQVQCVIAARLRRAYAATFKWRTRRHRCVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPK0</accession>
    <name>A0A9D4SPK0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPK0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14434" checksum="A13E1EA3388EEAA6" modified="2023-05-03" version="1">MVDASRSRSGGSNAFVLVREVSVVQWRQGHAKMMLSSLAQIIRFHSLLLPLDGFLTATSRTATETSSDRIRPQLPVKKKQASREGRLLNLSDVALPEEIRQVLQKGPKFSVEPALRPEEKIDTARAVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPS2</accession>
    <name>A0A9D4SPS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPS2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41777" checksum="2D13473494392EB6" modified="2023-05-03" version="1">MPAYSRPATGAPPVEQLSRKFPKHPPTTAIIGNSQTRYLHRHFNPHDRATPAIITIRGASTFDIEKELAGIPRSVTTLVFHVGTSELASYGLDESLRRLRRLVNNTLRTRQELERLVVSCVLPRYTNQRLERSNEQFVHRFNREARQFNETVKAYCRRPSKVSYVDYQFEQLPPRRFLAADGLHPSFMGVALIAETLKSALGRGDLEATTGWSTQPAAPVNIRSSQQNTHDTNPTYQHVPGAPHPPNIIAEFPTIGETMTPARPKHPLTIINSAPLLGGRSAGQPRRVPLLRTARSEELHDSTTTPLLKGKPAELRSRVPLLRTPGPELPTNTNILHSTLAGSPTPESSLQRRRPAGHNYNLRTSSVPSPHPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQB5</accession>
    <name>A0A9D4SQB5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQB5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="447" mass="49248" checksum="F1B50B031EA9F75B" modified="2023-05-03" version="1">MEASARTTVIVDNEMCVQVQGEEITPEEYHNETGWGWTLAGERMSRLRRRAPASGMPDGCGGSQARPKSKFNKNVRASVIKAARMPAMPLEESKIVVRPRGGLDIVKTGTTAVATAILAAAKITSEESAADTICPNTQQNIMVVSTPNENSAQGKLYEVSAYRTAPHDTVKGVIKGIPTDANAEELDRNVVNERNPLAVGAKRIGSTTSAFVVFQGPKVPNFVRYGVTLIPCHLYRKQIDVCHQCGRVGHRKDVCPTPTTKTCLACGLANPKEDHSCTPKCKLCGGEHSTGDRTCKAKYKMPYVVRKRQWVRRQAKLQLLRESDFPPLNKPSAVQKSRTPSKNRAPKSRDSSKKRSPSHERVGWVDAAKGNNTRSAQKITEATKKDDMNKVREANETLRQENAALRTTINNLSREIAEIHKLLLCNNESPQRPTPSSRETEETSTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQL4</accession>
    <name>A0A9D4SQL4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQL4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039336159" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q" evidence="3">
        <location>
            <begin position="21"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7942954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60601" checksum="7B5E9B2C10EC476E" modified="2023-05-03" version="1">MCSVLLDCLLGACIAWVVHWDNGFSEEVPWASLEWTETVVQHLQTLIQWLMGAPAGLKLNTALNNALGRFFLYHISLWKTYVGVVDPWVGALFSLWPGSLTLHLALASDLLALATVHMYCFYGYACRLYQGWVRALGALWRLFRGRKWNPLRRRVDSHRYDVDQMFVGTLLFGVLFFLFPTVAVYYVVFMAQLRLVVLCVQGLLSRAVLVWDSLPFYTLAARTVTGRPIVAFCSIEISMYGYPVATTHAMDTPAYVPENFNEMALVPKGPSSFPSAGIKDEAARDTSRLAAAVLGVIIALGVIVMAMTVIAFTSGSKSKDETMRTEEQPEITEKDMRDASGLTVVVPEFRTEDTPSPLTRKSTTEENTGHETESPFTDTESPFTDTESPFTYTESPFTYSETTDVATTPTIVTLPPAPPKRNKSERLLCTIGSKLSEPDMIPYDTLCDYLFYDSVYKEGPATFDPNNVDVALSILLDEHLESDQTAPGIGFAYRKIFTPNIVVIISHYLEGDNTFKDCRVMPPTVLTRPPALGNSSYKHDLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR14</accession>
    <name>A0A9D4SR14_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR14"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21134" checksum="A8456D9F6DCE911E" modified="2023-05-03" version="1">MSSRRSRSRSAPWDRSPAVRGPRYPSSRGRVRTLATWTVLDSTDRPVGWTSRLPWEIQPRPLLGDPPLDAPEPFRGLLSDRHPIEPPQPYMAEDTRIFCPICRVPEISRRAHQDGSLHRSRLLAAIIRDTIPRPPQPPPAPTTVEATVALLRSARPDLLVQGALPAPNSVPPPTLPRQLPVDDLLDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRX9</accession>
    <name>A0A9D4SRX9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043334"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1328" mass="145859" checksum="E11A1AA219A92D9A" modified="2023-05-03" version="1">MASTASISSTQLVLPDGVPDEDFVATNPDVALRRRTLYEDTGPLFAEPRSQPSQSKAFELGFEDLCCYDAAKPHPRISATIRKPTATPRSRNTPPELAAEMGDAACLVALSSQRRRKNSSCTTLRARDGESLGSRTRGGGTSRARTDATEEEPSVEVTWRTEIRPIEGQHSSGKQAMPVLARQKKSPIPSGEPDATNRVPLSVTSTSTRKPPAAREKEGASARPADKRQGLKIDISFGKSPGPDKDGKLLKSISTNVEKIVARLLSRCGEDRQPLSGVDDSETSVIELDSQRCVSVDVTIADDVGDRRQPWTSPVKASHGQTTSRAVLTARTHDATAAPSGRTAAERPRRDGPRRAPTPTSIVHLTVGPIHFGHSQTGLQAISEPEGERKAERWKTPAERLPTERTTSRTPRETTTGQRMRQTTEKRLPQAQASTGEPVRAIKQHLTPETVSYPEVKVKPDKQSDLTSLRAVDKDDFKSDQQTEKTRTQDTSLHSILKDHRGTEDGSKKQGKATKDGRGEAAETQEKRSKASESSKTLSGSGTKLSSPRDVSPTEPEGSSPIKQPSKRIAADEHKDPTKELPKEGADSDGTTGSTTAKTLESETGETASKTMRTQELGELDPDASAIERAQKQSLVRKERSEMGEKDLDDFRVGFELALSPYRVLVGLQPARPSSEDEEGTTKKGAKLPKGRKYSKNRRVSIVRIQKSDIKRKRKKGQIDTPSLLLEEAPQAAETGERAPKADHKKKRRRGKKSRGASQPPKKARKTATSTEGPSAVTAAASAATREGKISGAPDGSQLEPALNKKRSAHDSRRPSSEEPTSLRELEEEEEEEAKREKEKRKKKKRVKERKKKKRKKRKKRKHKKKRDRPIGYRSGNASCRVLCPVAIGLVFSVILLFMLLRALGYASPATFTATTVQPTFTFPALPTTTRTVPPPVPSPLPPVPPPVVPTAKPTPPPAKNVYVCPTETCKREGAYIATLLKSNSKPCDDLLDYVCDSWSRDHPVNPAGFGSFVSRGTLIQDALQRELLQVIRSAPDEDLKVVAGLHESCARRPPRASPLKFWTKMFKTWVIRTWPANPKAQTSDVWQFAAELLRDLGFSTLLAVTVGVGRKSPPQAVVELDRPELLFEEGDDRFDRVRAVIRGAFLELPISSIYPGSSQERANQTQDVIFNLARLPNDGRPYSTATQERWISVEFRELDGGLQYFLRKLFDNIVRPRQEPDVVLKSPAYILEGLVPFVNNAVPVHILNYMGFLVMVRLAPFLPGKKLDSRGLFAYSALGRSLPDVTDTSALCLLAVESLLPDCIAKAAAILRDRTDTDFGARDVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRY1</accession>
    <name>A0A9D4SRY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_006996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037458"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053509"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7943346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19045" checksum="13528A0B9238203F" modified="2023-05-03" version="1">MYEVYATREVVISAGAIGSPQLLMLSGIGPWRDLQNLQPIIDPKYLTHPDDVKAAVEGARIALRLMDSKAMRDIGAKPWDIPLASCEWAGPIWTDSYLACLVHHMAHTTWHPCCTCPMGSDGRAVVDPELKVLGVRSLRVVDASVMPTIVTGNLNVPTMMIAEKAAEMILRENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSA5</accession>
    <name>A0A9D4SSA5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_009747</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSA5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039435"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7947281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46308" checksum="72B657A3055ABC10" modified="2023-05-03" version="1">MPAHTFVALDYVVLISLLVLSAGIGVLFAWRNRRKNNRQFLTANRELSWVPVSLSMMASFVSSASVLGMPSEVFVRGSLMWTGAIGSTLAILMAAFIFMPMFYKMDVTSINEGGIKAVVWTDVVQVILIFTAYIMVIACSQYETTLFVLSFDTSPYETYTTWTMVLGFTVTLMGMYCANQIQAQRYTSIGSLKGARKALMLNVPGMALNMIMTVLSGLTLYAVYGRCDPRLTGDIRKADQLMPYIIQDLLYQYPGLSGLMAAAVYSSSLSTLSSGYNSLAAVTWEDFLRPCMETSESTALKITKVTAATYGILSMLIAFLVGTMESIMQAGLTMGGALCGPRVAIFTLGLLFPCCKKKGVIAGTVVAVMVTAWISVGSILYPRKRYTLPTTTEGCLHFNETITSGSFEPPRRPRLAGHLTHTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSZ1</accession>
    <name>A0A9D4SSZ1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033489"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAP3K deoxyribohydrolase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="MAP3K TRAFs-binding" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15995" checksum="BD5BD575741C6A75" modified="2023-05-03" version="1">MSEVDARSCCSVASTGHPQGKMNIACIIDLTTGTGAAGGRLAQRKAAYEEIKKASNCVGATLHELPFKKLDFGETKVLEQFHDADVAIIDVSIQDQRNALFYHLGVRESLAMKQNMILYNDHAPGEAYSIKVEAYFHKHFTYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST72</accession>
    <name>A0A9D4ST72_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="22">2.4.2.12</ecNumber>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HPB52_015301</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
            <tissue evidence="26">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="21">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="22"/>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST72"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027854"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040115"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH7947715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="736" mass="81599" checksum="1EB6E95F06F29DD8" modified="2023-05-03" version="1">MVGPYQMKYVVLIIASGFAIGAENNLIESFYEDQHESPPRFVNPAKMENAIKVQPTGGSVRLNCRATGVPEPRVTWFKNGQPLTFATSNRENGQRYTLMLTNLVRNDSGEYTCVVSNRLGSVQWTYTVEVHERFIPTPRIVCPFSNVTVAEGESLSITCDVYSHLTAFVRWIKHYHINGSYFDRNGAPYAKLVKDAALADVTDPHTLTLHNVTLADSGFYSILASSPSGASHKTIEVLVVPKPFPGLCARLSCLLSDNHCTQRAGSGADVLTIGSDFGLSKWDEVACDSDNVILLTDSSRVCHYLQYPEETTFIYSYFESIGSKYDKTLFFGLQYILKKWMVGPVITVKKINDAKEFFRMHFNQELFNEAVLEGSLIPTRNVLFTVENTDTAVPWLTGWFQTLLMQTWYPTTVATHAWHYKELLARYLHETCGSTASIPYQLHDFGCGGASSAESAAIGGAAHLVNFLSSDNIAGIRLVSQYYGFPMAGYSYPSTEHSTMTPWGPAGESAACRQVMHAFPSGPASVASDAYHAANCCEHVWGQDLRHLVEARAELHGGMLIVRLQSGDPPEIIVLEILGRYYSATVNSLGFRELPPYVRLMHSDGVTLEMAEAVLANVKANRWSAQNVLLASDGTLMREPRGPAQRFAFQCSAAIVRGQEKEVHRNPVTDTKLSSKKGRLTLQHSGSGYITVEHGQGNPEEDCLIHVFKDGHLLVEQTFEDIRRRSQEPLGHLLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU36</accession>
    <name>A0A9D4SU36_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU36"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050574"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7950798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="849" mass="92582" checksum="BC86E8BD4C7C5338" modified="2023-05-03" version="1">MTRNNHVTVTLDGTTSVRNLLQQHARPYDDSLLRRQLNKTAVGPAAAIGTAAASSKGQPVTEKSLLAQHLTQRNNEPNVVHLAPNEKVRVLRTSGGTVTVRSLSPVSTPIRVHTEQVRPPRSTVQTEPPRAPPRSIEHAIPSIPEQRRAPSSSPVMNALNNVPRRILPKPVHSLSFVANGGRIHQHPSVASVVQNATSRVRHVDPPVHATPNDVITGLKNMAVVHPQVRPAMSIKPIASDEPAKGVQLSKTAIQNMAANVAQKIAQPSTTAVAAAAAEQRALLEPNRVVPVSIQRSVPRPDVQRVDEDEGRKSKMIIVDLTEPIETSPTTKQGSATVGIPAETTLSTRPSVTDEPLPLEAGCLQVPSGLKVDFINLDDLLIGDLSYLAKYFGLSILEPLSMDDIANKGLSEWIDISDEAEVEKAFVELKALNGSSGQQLCWSNRMTPESSDIAYPIIVPEYEELETSNLPADATTPATTVKTADGKASPAGTSHSPRGTKEGTTKSPLILIIKKGANSSASSPAWQLSPCKSSPAKDEKEESKTLFCTALNLLPSSGEQLKKMRKGKSARALAVLKDKVMSEYLKNHFVPLHRVQGMYRYLFKKGHLREGKLTYACEVYRNLRSRENRPRASMVISRYDEEDFTPKKNQPASPGLLWHLKKKVTPKYERDEDYVPRKSQANGQKLRRSLWGRPKGSWRTAAANSDASSNSSTPSVEATPGSLTVYCTPLYKLEAGNWTPKCSADDSSRWDIWVSENSLENKMSRPIPMVVLTRIEDSAADSAGTSKVESPQRTVVSELFCSQCSYSCLNKPSLVNHFSSKHEGTDVSFKTVVMKCRINRSESAAKGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVT2</accession>
    <name>A0A9D4SVT2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVT2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054511"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22190" checksum="1CD4B5066F5DFFD4" modified="2023-05-03" version="1">MAVAAAPCERPGIEPCFGCVQAAREVLPTDGHCGCRSHYVPGQGLVVAYRCAYHAGQQEDGAEEWQGYDDPNEQPHMGFDVDEYQLGLDGRNWDVGDSNEKTRKEFDRRRATAAAKDPCAKEANEWMLTSERSMLPAYVVLFTLISCMLIAVAVVNILSSDEEDVSTTSIPGVPFLTRPKGRVPVAEFTTTIDNSSYSTDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVT5</accession>
    <name>A0A9D4SVT5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVT5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="9325" checksum="FC2AAB3CF6B70B8E" modified="2023-05-03" version="1">MKSIVFKQGDPGPRGLAGRDGSQGLPGHVGAPGPRGPQGEAGKPGSPGNPGPPGPPGRPGEPFGYDAAALQAILGRHRLLSEKVKQVSIYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWQ9</accession>
    <name>A0A9D4SWQ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWQ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053196"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7956331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="165" mass="19506" checksum="C3CE2F58CEA3109A" modified="2023-05-03" version="1">MGSYLLPNMTRRRWSRSGRRSEHLDEPREITFSYSLSDIEWYLCSNPDKFEILTFHPVEIVRQLILLEFDLDLYRAVKLSELVNAAWTKKDKHKTSQNYEERLVVVFRMLEVMLVLQELNNFTVVFVVSRAMSSACVHRLKHTFNSVKCSLKNALNEAFDLYSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXP6</accession>
    <name>A0A9D4SXP6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline dehydrogenase</fullName>
            <ecNumber evidence="5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXP6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026074"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="27086" checksum="7462CD2924D58AB1" modified="2023-05-03" version="1">MIDAEQSYFQPAISRITMELMRKYNKEKAIVFNTYQCYLRATYDHVVRDLELARRQGFFFGAKLVRGAYLEQERLRARTLGYEDPVNATYEDTNAMYYRTLTECLRQVVEGKERRSIAIMVASHNEDTIRFAVNKMQELGIRPDDRVVCFGQLLGMCDQVSFPLGQAGYSVYKYVPYGPIDEVMPYLSRRAIENNSLLQKLSKELGLLRHEITRRLLSGQIWYTPHGHYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXQ0</accession>
    <name>A0A9D4SXQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXQ0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="81" mass="9087" checksum="625EE5F3B2D85DF7" modified="2023-05-03" version="1">MKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANPLPAEQQQPLALLFTPASRNLPGKPREVTCLTRATPSASRITVAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYN8</accession>
    <name>A0A9D4SYN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048262"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001346">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF631">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9704" checksum="A763A8B16F0168B4" modified="2023-05-03" version="1">MWSFGILLWEIYSFGRVPYPRIPLADVVRHVSKGYRMESPEGCPSDVYELMRAAWQEEPQERPTFAQVLRKLQGLKLEAQHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ93</accession>
    <name>A0A9D4SZ93_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BCAS3 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ93"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052162"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="1">
        <location>
            <begin position="54"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="468" mass="49633" checksum="E915960B1887894F" modified="2023-05-03" version="1">MAAESHRRGVKPSGLVVRPQAVINDKSYMGSVVDLINEVIPQAYTQTSKAEEKETIQWVRFAYTEVNDGSRDYNGTAPPLLLVVGYVNGVQVWCVSANGEAQEVLSWRQGPVRALNILPAPDSSCGNDPFASKRPLVALCDSSSPAQQFCSVSIVSLKTMDQVHNIRCKEPINEIRASKRVLVVTFQDKICVYNACTFKERFCITGCFPVSGPNVNPIALHTRWLAFADKALFPVHQTRGGVAGEGTQSYTATVIHAAKTLTKGLSLFSETVASSLTGHKAPSTTTSSKKECHRLGGAMSGGMGGAVGASTSLCPGVVSVVDVLGVATGSFSTEEDTDTEGLVAHFQAHHGEPLSALHFDPSGVLLFTADRLGHNFHLFHLMPHPGGPTFGSVQHLYTLHRGDTTAKAVASLGDEDIVAAVAGTQDAQADSSSGDEDRLDEVAATRAYSAAEVVAAFGSVQRSCGDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZA4</accession>
    <name>A0A9D4SZA4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_016511</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZA4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049391"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7957244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17332" checksum="C4CC5A19001FF1C3" modified="2023-05-03" version="1">MQDKGTTQYDLVLVGHSLGAGAAAILAILLKQDFPNLLCYAYAPPGGLLSLPAVEYSKTFITSVVLGKDVVPRIGLHQMEALRTDLINAIKRSADPKWKIILGGVLCCCPDEVDFDGVEGPTLADRDVTSHPSDATIALTAHQPLYPPGRIIHIVRNHPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZA7</accession>
    <name>A0A9D4SZA7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZA7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11680" checksum="DA9C726986344C00" modified="2023-05-03" version="1">MHGVAHADATVLTELASLEALADVIQTNGSNGFTLLHGSLEQYSEMQVFFIAWCFLRCGEQRIVDGENVEVDPCSHVLRHVRRFSEAFQCSSGTFLNPDTKCEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZC8</accession>
    <name>A0A9D4SZC8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZC8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051994"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="14786" checksum="D8738F1BCAC37167" modified="2023-05-03" version="1">MDLIDAKEAARDPIPEDGVNTKPPATREKSKDIVNNKEPDPMELKTDKKADSVSDLNVAPPSITTCDTKEAVDVEMATAASTSAKRSRDTGQDDVGNTKKIGIDEPPAKTFPLRRGSLKFKPTILPDRKPPPANPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZG2</accession>
    <name>A0A9D4SZG2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZG2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049115"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="59"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="442" mass="49549" checksum="D4C40B5014E28D55" modified="2023-05-03" version="1">MNEIAKLEYLSLVSKICTELDNHLGINDKDMAEFIIDLADKNNTFESFKKALQENEAEFSIYNGKVTNIMQFGCFVQLEGLPKRWEGLVHISQLRREGRITNVGDVVTRGQRVKVKVLSFTGQKTSLSMKDVDQDTGEDLNPVRRAGDTDGTESARNPDRPCSLPLLTRPDDDDVDNRRRVQRISSPEKWEIKQMLSANCIDKSELPDFDEATGLLPKEDDDEEDLEIELVEEEPPFLRGHGRSNLQDLSPVRIVKNPDGSLAQAAMMQSALAKERREQKQQQREAEMDSIPAGLNKHWIDPMPDADGRTLAANMRGIGLMTQELPEWKKHVTGGAKASYGKKTQMTILEQRQSLPIYKLKDELVKAVMDNQILIVIGETGSGKTTQITQYLAEAGFTTRGKIGCTQPRRVAAMSVAKRVAEEFGCRLGQEVSWVSLTSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZX8</accession>
    <name>A0A9D4SZX8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZX8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="102"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="520" mass="58215" checksum="C7A39A16115D2EED" modified="2023-05-03" version="1">MSLGGRKRISSHERSSVAFKTGTFQKASTFFHYVPITESRHHTENPFPVRLVLSVMVIAILIIAIALVMAKMLASQNGFCTTLACREFAELARWSLNESVPPCEDFGRFVCGRWEKRKRSEASTRRLIYVTALEMIFKSLISALSPEERQSVRERVGAFFRSCNAVTRGHSDDVGTVRAYLEEAGVTWPLVPSNPDVMDTLLYLDSKLNWPSIIQFHVKEEKSVVKILGDAIFAEFNTKVFTTEVRHDLRNLVLAVRKSFVRRFSQSSFAKYISLVANWGKTDHVFFVLESHRHNGLEHAASSLPEMSDSFATNWRIASQRLRTLNASVGVLGEDVLSGSSMFRLDWEVMDFILSPFALVFPMYNFELTRAVKYATIGGQVGVAAAQLALGRLAQQPAAQFELTRSHQCVEKAFEKHAAMASTAVLELASLSSLSDALAESGNNDQRLPGLDNYSAVQTFFIAWCLMRCHDVSSRRDDDEPCSPVLRLFEAFAHAFQCWPGAYMNPSTKCSVFESPNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T049</accession>
    <name>A0A9D4T049_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T049"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="568" mass="64196" checksum="7326890933BFECF9" modified="2023-05-03" version="1">MDNGMFRTCFRFEKEDVPKLRVALHIPETVMTAQRVPIPGDEALCITLRRLAYPNRLKDLENFFGRHSSTISSLTIEQLLDDVINHSWLTIDTLENFSKRRGLFACSRSCAALGGAAEDMPPSLVLGAAILKTLVRSSAGRASLRRRNERVSDSLRKDARCPGVPRMRSSPPRSSAVRAGPLSRNVVGLSLPKVDLGSTTNVCTLRHITSASTSNDPNQDRHGRRTTSWRNLRRSYRQNICNINERLARRFPNRTFDAIKYHRRGQRYRDLVRELLEAATAASRREALHGPECNGAEQEQTSETDQDTISEVKRELFNLTQYPPPRSCQAARLWEKTKRYLEGQVVTRRLNVYLRDVFSEDLRGVCRAPQRPQGERKRQRKKRKYAEKERLFKQAQTRCARKVLDGSVKSGVTDPTDFLIRWRQVMEAQQNARILPRVDSPTAKFNPQRLTTAAEIKSAMLPTNSASGPDVFPARKLRNTSTRPSIGQNTQLIRQNHTNSSETMAGIIARCASWVLLCPTRRRRSGNPVCEDKCAGPTPRLQRLEQSTCPAVVEAGGMRLVTTSLTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0L9</accession>
    <name>A0A9D4T0L9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0L9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="173" mass="19856" checksum="11E72C4B46C651B5" modified="2023-05-03" version="1">MAKVPENKHWEIVELYFKGRSQRKIVEATGRTLKAVNRIVRTFKSCRRIKDAPREPRSRVTTEQEDAWIVAAAAVKPGLSAQQIKNTLDLRASVTTVKRRLREAGLKSRIAAQKPLLRTQNKEKRLQFSRQHAQRSTEECKQVVFTDECTFTTSYQPKFLQRVSKSGRSTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T156</accession>
    <name>A0A9D4T156_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDK-activating kinase assembly factor MAT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CDK7/cyclin-H assembly factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Menage a trois</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RING finger protein MAT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_015915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T156"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044788"/>
    <dbReference type="OMA" id="QGLYYTA"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16517">
        <property type="entry name" value="RING-HC_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7962397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="314" mass="35660" checksum="EF5C8255C7FB7D09" modified="2023-05-03" version="1">MDELACPRCRTTKYRNPSLRLLVNVCGHALCENCVELLFVKGSGACPQCNVPLRRGNFRLQIFEDSKVEKEVDIRRKILKDYNKREEDFETLRAYNDYLEEVETIIYNLANEIDVEATRRKVEQYKRENKAQIQKGKLKASKDEEYLEEILEQERQETELRRDQLAEVEKAAQREKLKQKESLIDDLMFSDMPASKILASHGDKLKQVAGPKPLPPKPLAAEFSTGIKFRHKEAFLPIPKVVEGPLYKYTAPTLDLCGPTAPSLESLSPLGYTNHVRATVEAEEAGGFLAGLACQRALQDAFCGLHFKVAEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1F7</accession>
    <name>A0A9D4T1F7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma tubulin complex component protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_019355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1F7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034537"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="670"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7963046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="773" mass="85784" checksum="5E3EBFDB7FFD8476" modified="2023-05-03" version="1">MSLPGDQSLRTYSSIEGLGNGTTSNHKVFEPSDQAYFQQKIEVPYTGETSFSWRKLWAFTGPGFLMSIAYLDPGNIESDLQSGALAEYKLMWVLLSATLLGLMMQRLSARLGVVTGLHLAEMCRRGYPRFPRILLWIMIEVAVVGSDMQEVIGTAIAIFLLSGGRVPLYAGVLITIIDTFTFLLLDKYGLRKLEAFFGFLILVMAFTFGYEYVRVAPDQVRVVEGLFIPWCSHCDSRALLQAVGIVGAVIMPHNLYLHSALVKSRAVDRTDKVQVREANKYFFIEACIALLVSFIINVFVMGVFAHGLFGRTNLDIRNQCMGTEFQDVFANNTESVDVDIYKGGVYLGCAFGMFPLYVWAIGILAAGQSSTMTGTYSGQFIMEGFLNLPISRWMRVLITRLIAIAPTILCAVFGNIEQLSGMNDLLNALMSLQLPFALIPTLTFTTSAAFMGEFRNGTLTKIGASLLSMLVIGINLYFVSNFVRESLPSHWAIYLGVALFGILYLGFNLYLVNSYQLVPTCESVHAVYENTLAALGLAIESSQEDDETRVAEQVIQSFIGKHKEKEAVRFSDLYRRLRSPALDGVLPRRLSLLKLLLFLQDAGEHQGTTRPSLEPYRLSQRRAPSQPTARIEFWPPHVGHAATEGTHEHSTPAGGTQVVGATSHVGQKVLRDVLFSLQGVSSSLVQFHDLPLGSFTVDSECQLSSPQRQIVRNLAVLGRLRILVDGFCRPETLRRGLLCEAFVGALQNEMAEYYRLLALLDTQVTLYFAKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1P6</accession>
    <name>A0A9D4T1P6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_020541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1P6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7963316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16834" checksum="4E3E0DCCDCB08C50" modified="2023-05-03" version="1">MCVGEIVKSQAVAATVECTRCAHRIDRSKVPVLKEEDVVEQFIHGSGPGGQAVNKLSNCVMLCHTPTGIVVRCHESRLLHENRKLARKLLVEKLDEHLNGDMSVSAQKLRIKRDKRRKLDRKNEKLRELKRQFLERQKQGDDSGAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1Y7</accession>
    <name>A0A9D4T1Y7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1Y7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049026"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="433" mass="49622" checksum="CEB669BE76E1A91C" modified="2023-05-03" version="1">MTATPRLKPSCSHEDGIVSSQRTLLVFCVYVVPENTRNKANKAPVDLSFISHFKKLYPQDTKLLCGDFNSQHVAWGYKQCSPRGRRIMQDASEYRLTLLNAPQTHTRLVQTARKADTSPDLTWSTRPQLFRWEVLDDCMGSDHFPILIHFRTGYANTKKPDATTRLSHITHWDKYREFLQQQPPAKNIDRLVSQLCAAKRKATRNLRVPFDHPEPERHLLSLWNRRLRILAQYRRSGHAAHHKARLRKIQRTIEEYTTTLASDRWMVICESMNGQAYTSKVRAMLRSLFGQRKTYNGAARVALGEGISAQELAEQVTQVFFPQTSHPTDTTYQKDESSEDSEPLNSPFTMLELEHALQHANARSTPGADGVCVAHLRNMPFEHKRALLEEFNRIWDAGILPSTWTFSVVKPFPKPGKPPHTLSNFRPTSLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2S4</accession>
    <name>A0A9D4T2S4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013716</name>
        <name evidence="3" type="ORF">HPB52_017122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2S4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="568" mass="62612" checksum="EC1729E4C97EA471" modified="2023-05-03" version="1">MNRCDRTTASSADCSTATEKVAKDKMVSGGGGARARARQPPKTGNGKTWTSSAKRGGEGKFAKCSVASAASPGPPRGDKSGAFDSLLKRAQRRRSSGNTSEKAVGKHGTRGDVADDIDCGRPVDLGDTSDDSKKTKEHVEQQPAREDIPHDSTCHDSVENKPAADPVEYTILARPERQRAAAAEGQFISPSQGTSCEEENVSLAPRDVHTPSRDLRFRERTRRCPVASYADAAFMPQWSSPEKGFYPADCRRPTFAPASRSAPGCIADEMNCFKLAEVAVHPSMHYPEVYHPLPPPPLVPSPVVPPPFPGFGYFADRVSRRRTRSFPRRLPERRLYDAHGRWVGQERRSLQDFDEEGWSLSLQHQPCRDGFCSYAGGGRELQRSPCDVPPRGYNRRHSWSHPSVLHDDDIEDLLPLIDKLAVDYANSDSSSAEGAPPEAAAHIPDEGSWFSVLPETTRPEDRFIWSPRRDLHRPRSVWSPIKPKLGGSQQDGLRESLTRAKYRFRTYTENVFQASVDAIVEGRRSVSCEFPYLDDDASSFAANGGEAHCSGWSPWSSQLPTADLLNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Q6</accession>
    <name>A0A9D4T4Q6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Q6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF6">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="316"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7970082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="413" mass="46331" checksum="AA8A98236C2EB628" modified="2023-05-03" version="1">MSQQGTLSSKETPQRKAAPCFTEDEKNTDSPPLKKRKIRQCTFRKEWRSQPEYESWLLPVDDDATAARCTICASTFTVKFDGVSAVKHHASTQKHKQKSLASKQSATVKKFFVPAISSAEDHVTAAELGTIFHGIKHNYSYLSMDCGSKLAPKVFSDSDIASRMRLGRTKMEHLVKDVLAPYAVDGAGITDALIDFCEQADETSGGICELLATSLEKANLGLEILPGGQVAKLEFLNVYDRALAYLEKWFDFENSPFKMLAELDLRKGAPTTLVVINAGNLFGSDFQEEGDELYSELCLLKDALPGLLKCDEKSSSMWLKFLKAVKCPLLQNLMEHVYSIPCSNAFVERVFSVMGNLWTDERNQLSVPMVKAELCVRYNLVYSCEEFVKMARENKKLIRAAKSNSKYIFKFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Y6</accession>
    <name>A0A9D4T4Y6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_004605</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Y6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040426"/>
    <dbReference type="OMA" id="VWQYLEN"/>
    <dbReference type="OrthoDB" id="6487415at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="130"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7975717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="472" mass="52171" checksum="D31BF3D62540546E" modified="2023-05-03" version="1">MYNKTLRVSIIPYKPHTTMVQGPGDQVTLYGPLGNIFNSLVQVLRFNYTIGVPRELTTGSPQPDGTWTGSMGMLHRNESDLAMGPFFPATERLEIAHPSAVFYLEELRILAGRTTAQESSVFGYIMAFDWMVWMFLSVALVFISLITALFNSMHASRAGRSYSFYGFFSDAVWQYLENLFFEASAHAPSLGGERLLSAAWWLATLVLMNAFCGHMRACLMIKSEVEKIESVRHLVRKPSTVPHMWLGTSYVAMVAHSTNPELRQIGRVVRDRGTAVPASVLYGQPLLRRVVQGRAAVISDGTSLVFRISSVCQSYEGAEFYLAREGLVSHPLNSFARKDIDPTLFRNINKVIRRLVEAGLVNYWWTRATGDVSRCGGSSSSSGPEQTASTLAFADVFGVFVLWLACAGISSVVFLAELCTPRTDDMFKKRLAAVAAARARRGRLAHRLQRSPSASQSSNAAVAGLRLRLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5D7</accession>
    <name>A0A9D4T5D7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5D7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037049"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="24835" checksum="DF7CA54970D70524" modified="2023-05-03" version="1">MQKRCDNATPTPPITQKGMRAYARRPGDSALGLARGECAPKGLACHRCFRLPRRRGGGGGGPDGRLYGQWGSPFGGCATVEKAPGRLSRHSSSAVCTVSLLMAVQFIFAASVEVGSSTIANCFCKVGFAGNSSEAEVEGRDAPADAEMTELWSSVNGGGDASGLYEFLHADGAVAINEDLTDEAIVAADIGAEDDSSDDEGEPEPMQVVSHQEELQMIDSLRDFVFAKTFRSPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5P9</accession>
    <name>A0A9D4T5P9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polyadenylate-binding protein</fullName>
            <shortName evidence="9">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_014752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with dazl in an RNA-independent manner. The C-terminus can self-associate and also interact with the C-terminus of pabpc1, independently of RNA. RRM 1 and RRM 2 interact with both eif4g1 and paip1, and the C-terminus also interacts with paip1. Prior to oocyte maturation, found in a complex with dazl and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation. Interacts with the translation termination factor sup35/erf3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5P9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037721"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000001">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000042">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000049">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="295"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="12">
        <location>
            <begin position="575"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7972648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="661" mass="73088" checksum="78C9D5AAB56EC674" modified="2023-05-03" version="1">MNPSGPNYPMASLYVGDLHPDVTEAMLFEKFSTAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDPIKSKPIRIMWSQRDPSLRKSGVGNVFIKNLDKTIDNKAMYDTFSAFGNILSCRVATDEEASSKGYGFVHFETEEAANKAISKVNGMLLNNKKVYVGKFIPRKEREKMLGDKARCFTNVYIKNFGDELDDEKLMVIFEKFGKITSAKVMTDENGKNRGFGFVSFEDPECAERAVDELNGKEMGGRVLYVGRAQKKAERQSELKRHFEQLKQERLNRYQGVNLYVKNLDDALDDERLRKEFAPFGNITSAKVMTDGNGRSKGFGFVCFSSPEEATKAVTEMNGRIVVSKPLYVALAQRKEDRKAHLASQYMHRIAGMRMQMGQMFPPGGAGAAGYFVPTMPHQTAQRSYFPATLGPAQMRATPRWTGQQQQLRGPGGPQAGAGGPQGGQPQGGFPTSLPYQRQPRPSLATQPQRGALGSARPITGGQQAPPPQQAPPQQAQSAPRVMGPRPAGLAPQTAGGPRPTYKYTQSMRNPPQVQQVSAPVAAPFQTQQAAVHIQGQEPLTASMLAEATPHDQKQMLGERLFPLIHRMYPDLAGKITGMLLEIDNSELLHMLEHHESLKAKVEEAVAVLHAHQAKENVAMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T612</accession>
    <name>A0A9D4T612_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T612"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042561"/>
    <dbReference type="OMA" id="QNEDEPM"/>
    <dbReference type="OrthoDB" id="6504155at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="242" mass="25325" checksum="2E8EC2DE15F2D88F" modified="2023-05-03" version="1">MGCANAKAAGIPSSGKTDYPLEVTDSSDGTNFISNQVPKVVINGGDVLDNEHHINGSADDAEDKANGNADIPGTETFLPPPETPQETEFLTPPDPPKDDKDDREAVADRAAETPVEDGNDAIDDGGDDNGNRQPPNDVTTDEPMPDAGDGVVTDDASEVGVVVADDNANDVTPLDDVAHDAVDRMGPDVVSDAPTGNDLPRDLNEDNGIVPKDIFVDDGLDYDSKKADRQSNAGHDLIVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8I0</accession>
    <name>A0A9D4T8I0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_002612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8I0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056407"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039370920" description="C2H2-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7982022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="341" mass="37765" checksum="0B9FDD940D213A46" modified="2023-05-03" version="1">MADWVVILLLLSHVGWNGPSSPRVQPCSRAQSRVARQLVRRKVTAVLQRYRVSLGPECPLHPSRDLFWWPPGLMADEAPAADPPQPSWSCPMCGRSFFCHEKLTSHWDEEHAANVAPKAERGVCVADYCDILRCDVLGPRLAAAERASAGGSAVATALQPDKPKEVEAHGGRCGEPPADHPRCSCDQKHMSALQQKCRIVVQQCVIGLLSVLSVKDFQDIEDELNNNICSYLTCNKYWDDSLNEERRVPMLFSMIIGIILVGGFCLCYYIVWILFESIPLPSLSSPCDGAPYDDVYCNSQVRFSSFGLASGGRDGGHARQCHCRFVGRHAYHKHSVAASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8J7</accession>
    <name>A0A9D4T8J7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_003008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8J7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7982112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="34892" checksum="5D19A196C314B8CD" modified="2023-05-03" version="1">MFVCTYAAPLSPSKEEFIQASQRHASLSLRSWKSGGCELLDFTVKLRQGAALAWSTVAEGLPANQTQLLLRNLTPGATYHVHVVAAPRRVLPRPNTNVASVEATSSQPKRSSLPSMTDLEILVPILVSSCVVLIVIVVGCILCSRESLCADRHCGRPDLRATYSEEVVDMKDLANTAECMARCEDSMHHSASQMNSRFPPAGQSIYAQRPGKDDRHPYAMPYDVLHGGGAGGAAEGAAAEDGNGADGAGCQNHLDGRSTLKRRSDLKDHRSNNIYISRQSLSRTKPRERPYESLMVNMNPYPADGTTTSTLSRKDQEDIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8P7</accession>
    <name>A0A9D4T8P7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L3, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_006177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8P7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036950"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7982625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="268" mass="29747" checksum="D098573902B1C370" modified="2023-05-03" version="1">MWTNTGKRILTTLIQVLDNHVIDYLPPEQYAKTRFGFRAPGLGCLIVGAGSIDPMNFKAPYLKLFEKSGVMPKKKLTRFLVTPDAALPPGTPLTAAHFRPGDYVNVYGKTQGHGFQGVMKRWGMKGGPATHGTTKAHRRLGAIGGPRGIIQKGKRMPGHMGQERRLLVGLRVWRINTLHNVLFVHGPAVPGHTLALVNVFDSRHGKKGHSADDPPPFPTYFPDAEHPLPEEMYDRELHPFEAPSVTFEEDEVQVKKKAKVKAKTKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9Q9</accession>
    <name>A0A9D4T9Q9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9Q9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029538"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14167" checksum="00CE92D357635A59" modified="2023-05-03" version="1">MVVTASALQHGGRTGCSNALPLLARVQERLGLVIDALGQASCAAQGLPAPVTTSDRLRNSGHRVYLLVEPSARGGTVLGLLKVGFKQLFLRDGHGRLCQVRPLCLLDFYVHQSRQRKGYGRRLFDKMAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBI7</accession>
    <name>A0A9D4TBI7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_019879</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBI7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037534"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7984364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="329" mass="36757" checksum="5F24112258150FD0" modified="2023-05-03" version="1">MHGSGRRTFEGGGRNPGHAAMMPAPYAVFNPQAHNGGRGSGPVACCGPVTIQDVWASNLEEAFHTIRHMVQQYNYVAMDTEFPGVVARPIGEFRNAADYQYQLLRCNVDLLKIIQLGLTFLDEAGNKAPDCCTWQFNFKFNLNEDMYAQDSIELLVSSGIQFAKHSEEGIDPYEFAQLFMTSGVVFSENVRWLTFHSGYDFGYLLKLLTYKNLPADEVEFFELLQIFFPVIYDVKFLMRGCRSLRGGLQEVANQLQVERVGQQHQAGSDSLLTAGAFFKMRQVFFNDQIDDAKYCGHLYGLGPAFSSTSSFCTTESDPLPAPSGTKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBJ8</accession>
    <name>A0A9D4TBJ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBJ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047593"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="18290" checksum="EDA3462354D5CA2A" modified="2023-05-03" version="1">MPKKQEDGKEDPPKAGRAKPQAADDAPGPSTETPAAKRPRGRPPKAVSVDPLAPIPIAATAARKLRKAEDVAQPETESPSTSKAVPTKARRLSPRKRPRSSSSSGTVDTASDAPKRRRAKRRSYLNRVQRRCKGSAPRNPEPRGDTWGRTQREGLALALRPPRRNCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCH5</accession>
    <name>A0A9D4TCH5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024399</name>
        <name evidence="2" type="ORF">HPB52_025197</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001139">
        <property type="protein sequence ID" value="KAH7984982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000576">
        <property type="protein sequence ID" value="KAH7986123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCH5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041648"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22645" checksum="8054A47719BA8A7C" modified="2023-05-03" version="1">MVMEGTEPTDSWPGVPCIVKGWALFMERILTLLNSIKITQQIHTDYFSVLMKKNEDALLEQVDLPDLPFSSLFAFQQFDEGLLVDAKKRRATRDHIAIPGGDTTKEKTSRILRTILAPAVATEFSWFGAKGKKKFVDTNICKLMCTTLTDKQVSTQVTATIKEIEKSAMSWFRHAAERAAALQKKMEAEKCFEMPDDHAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCY4</accession>
    <name>A0A9D4TCY4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000793">
        <property type="protein sequence ID" value="KAH7985637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035843"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25585" checksum="A9C43936D68DF04C" modified="2023-05-03" version="1">MRVVDEALRRYGLSNRTSLLNNWMDITAAVSTINATFRDRISTTVTRDLVANHQYSFYDNGSEALCLPPLFSMLPLYRQSLGETAKFGSLGTLFATAIFQLYLSKINSYPSIMDEALKRLRCFTELAEHRSDSLELYHQAASVKLALQALQSHSNKDNQRLRIFRSDQVFFVVMCYLLCNPNTSEHVILAEAICNEAVRNSREFSTAFGCPAGTPMHPWERCTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDS6</accession>
    <name>A0A9D4TDS6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000339">
        <property type="protein sequence ID" value="KAH7986648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDS6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13810" checksum="25D75A53276001E9" modified="2023-05-03" version="1">MEQPTETATTPLSYVIMEAPAPATPMYCTDQNPLTPSPFRGDLFQDVDDWAAEKTEEEEGNGATPDVYDPAVAALAKHFDTTCNLVVERHRFHHRIQFPGESIQEYVTALTKLAAMCSFTSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDT4</accession>
    <name>A0A9D4TDT4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000326">
        <property type="protein sequence ID" value="KAH7986680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032244"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="118" mass="13695" checksum="4AA2951AA58FC9BF" modified="2023-05-03" version="1">MKHIKRFLFSAPSAERPLEPVDPFPLMSLPDQLIEYVLSFVSHTDLLKSCRNTCKLFRNIIDSNSFWKIKCLRDGKIIPVFQLQELPPRYYQRIYTGNPYGRNLLRNGHGDSPKGAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YNF1</accession>
    <name>A0A9D4YNF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YNF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="605" mass="68322" checksum="3D86D3C41805170D" modified="2023-05-03" version="1">MAKRKSPVSLYRLCVVYVSDTIDSLCPADEDIFASAFPLHVSKDLVVQSLKQQNFTSLYHLLKHRLSRDGLRYIEHRLPTAILSRLPRLVRETPAPGKHLVELLLVGTMNEDDRRLVEVPGQLPHLRRVTRCTRNITDRAQVPVAENRREFCKPSFWNQRVADGSFYQLVACQQLLASEMYFDQPVTVWSSFDLLYGLSCQQTAKIPFLAQALHAFPEGCKLNIVEYIARSLGPRLQSTTVLPRIASSFPLRSRVSLVLTGQENILPLGLLTVFNDRTLGIISANLKLFFLEQAELGLDIVGTGRKTLTLWMFQLYVAASSEHCPFLRNLDLEDLQTLIPSEQPSFLQDARFRWLERLKFFFNKMNVTKPEQLPWLLRNRDKLTEVCFGLFHLADTSAEVASGTFTNRHELELNGVEFVSLTGSNQLLRLSRTPTGRNLLRTLRLEPSGTMRNEEAWSPIPIKVAAHMQLKPLPRNMNPQRHPGRRKARADYYIRWYRNRDDVLYVDAAVGPLEGTATAAAMTEDGRINISASIKTARPDVAEGVALALAVAHAAADSTITEICTDSKAHITVSRIFQKPKHGFTHFAKHSFASPSGDYHVSAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRN7</accession>
    <name>A0A9D4YRN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_025501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000799">
        <property type="protein sequence ID" value="KAH7985634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038455"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7985634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="66" mass="7103" checksum="A508EA64010D41E4" modified="2023-05-03" version="1">MMCAGYKEGRRDACVGDSGGPMMLNLNGRWTLVGITSAGFGCAQSFQPGIYHQVSMSVDWVIANMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB29</accession>
    <name>A0A9D4PB29_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_008403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB29"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028038"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7935469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24683" checksum="3B163397901C31C9" modified="2023-05-03" version="1">MHNLLHELHLRTHTGPCTKGQTLSPCAGLEEDELCRLLCPRGRLELPREPYNEVYPGVLLGDGTTALCVGMLRRLGVTHVLNAACGRDASLCLVNTGPALYRAAGIRFLGIEALDMAGFRLDRFFDEAADFIDSALAEPGGRVYVHCHQGISRSATLVIAFLMLRRRLSAREAVRLVRARREIVPNRGFLRQLCLLEHRLTRTGSHGMPTRRQAVPGCGSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBZ0</accession>
    <name>A0A9D4PBZ0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBZ0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10568" checksum="6C8646289FD338CE" modified="2023-05-03" version="1">MEPRFAGFYAEKRKTKRNTPKTASNRLVSEKHVQEEATNACSRLSTQRPLRLMLFGEGCWLRPPGNHGKLRLTKQSTFSTPWKSRRQPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD13</accession>
    <name>A0A9D4PD13_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD13"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="340" mass="36680" checksum="FD455EFB5E87913B" modified="2023-05-03" version="1">MSPVSALTVVVLVQLESWSGHVEMLHTNATVTSNEPLQVVLWRLRSFSKSCADRHRVAVANRSLAIARDNGPLMFKRLPQGFYCFSAMSHRGAKVLSSVAVLTGVLFVLSSGRGWKPNLAHYDSCCNLHALMPPSVPRRDEGQGPRDRCCERAPGQGLLWTVSPDGTLSASVSVDSSELPCQQFVARLHEGACVGDKLVVQYQDNGINLPRVISIAITVQSKTAAIVTTAAAQVVRNVAFHVHGLKPDLRYCLTVAAGCFNCPMTCSALESKTVGVHVERTADDALLRGEGAAVAADPESVDPVLAVLGVGSVLFLLAWSFHLYQRLPTRTKRRPHVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDH8</accession>
    <name>A0A9D4PDH8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDH8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="142" mass="15816" checksum="C547363D706CB82F" modified="2023-05-03" version="1">MFLERLDNFCLVSGTDEAKRLGNLLQDLAEWSTLKDLAMEADGLMRTAWRRRQYKSLPPPTNPTIMASANSFRQQPTSATATVGMTVQPSYIYDQFHRATTVPNLMQLLAHATGHSLAAAQPTSPLPALWKDQTSCPPMCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEX4</accession>
    <name>A0A9D4PEX4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033783"/>
    <dbReference type="OMA" id="SCHSGHI"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37938" checksum="F06716E9500BE696" modified="2023-05-03" version="1">MSASSEEHADQEVPSTATGGADGACDSVTSSATTGTESCTKSPAVSAAHSSRGSTRSWTRGRTRRTRPHRRKRATSSSAEDAGATLPDLEKPQKQERRDDAPTSNRVSIVQRALSEPDSLTPVEVDRLVRVVFWKAIHDDDTAGPAARFCASVITAELDGMFIDRLLWACRDWFKQRDVPLRRSAAKAPAVPLMEHDAGHQLTAFVSFMATLLSAIPGSGTAASVGSCHSGHIFCLAALLCDSCKLVLRSPDLDWQTKVECLHSALTTAGEAAERGAPTRMVALVACLRDAFLSPDASEENRLTLLELVELRASAWKLSLEQQLHYTRLSDGAAEECDDVQNSLPLPCRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFB1</accession>
    <name>A0A9D4PFB1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFB1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="7543" checksum="B520A861004A0EFA" modified="2023-05-03" version="1">MAFAAPPPKAHCFTFSAPERSTVDDVIDALEVVTGPAGIKSLQHMGGVKFGAAAANVHAATKLKSRGAILLNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH64</accession>
    <name>A0A9D4PH64_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH64"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053800"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="186" mass="20885" checksum="33CAE1B3B37A2997" modified="2023-05-03" version="1">MPPFPSAQPFCEDNFSHLIGSARVRYKETIELCENVDPYTLRLGTDTSADSSLLPSIAHGDIVNYLVFSTSFVTLDQMKAYKALESHDYFTSVWVKSLSAKRLGEDKVLLLVEVNHSQRLGERPLKVWVLCKQSGAVVTVPAWQGLGRHAHTFVPACSLLKQVPGSTSRQLVLRRRMPGCRLMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI75</accession>
    <name>A0A9D4PI75_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058284"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27551" checksum="09631BA7D615222C" modified="2023-05-03" version="1">MRVAIWASCATINYQALGVHRGVPNEAVQGEVGWSSFEAREAVAKLAYERRLSQLPDGRWAREVYKYIHLKCINTRWVLRTKRLAERYGVAPCRLTEKPQRDRRAKVREAVQEAESACWRKTATEKPALSLYSKAKQEIEKEPMYENSKGSGLLCEARCGMPRTRLLRARYTPNRDTTCPLCTLEGESIEHIVLHRPALKLQRPRDFTNFTTFAAVPHPPPTPPAAATPPDEEEPEERQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIJ3</accession>
    <name>A0A9D4PIJ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIJ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044899"/>
    <dbReference type="OMA" id="WTIAYLR"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="76173" checksum="43118941D2B9C717" modified="2023-05-03" version="1">MSHKIRIGTKEMDTEELNRRFPGLGLNVPCSAAGEDGSRVPTSICHVFDNLCRWNYVLWYVGLQLRELRGPGRLSLVRVVYRGRGGRIVQTRSRHARILFHVLLAQHSCVESLHMGDALIEGSGLGEYRECVVSSLRQNTSLRTLLLGSLFSEYRSIREELFRAIATMTNLSELAVFGSAAAPSVVLDAVCALLVDTRCLTTVTIPRLVYDDASANRLIAALRRNQTVENLSLHGSIVHSYMETGTSRFSHFLANSTQLSSVSMEGVDTDPASTFEDIKCIVVPFRIRGNLQKLRLSGFLLSAPCACLFAALMSGNEGCLKSLDIAGCRWRLESRLEESYDVGTTDGEQSGVPYLAHHSCDMIQALDHTARVQLSFLALGIDGLEPEDLRCLLNIATTLESLKTISLSGVPLEKLKAVCQVIRETTMSGRVRIEDAYLVDSWTIAYLREYPEALSKVAIRSFTEHNPRAFVIVVRLACSWYRVTLLHLHLAQGILSDVPTFRALSSCLSTSDSLRVLSLTGCDEPDLSRTLRSAGRPHSVLLEMIFKNAAIRALRLNGLRMGKDNLHFFVAAVVASKSLCELAFASCNQAENDTFLRLLSSTFHGSKTITHLRLLSSTECVGDEWFVIGNVIGRNVGHLTCAAHYVVYKDYSPRCEAAFAIVSGTNALMKRVEELVNDVETTGQFPSTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIN5</accession>
    <name>A0A9D4PIN5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein Njmu-R1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIN5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028640"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028280">
        <property type="entry name" value="Njmu-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416:SF2">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15053">
        <property type="entry name" value="Njmu-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46476" checksum="F22AF916D9B532BF" modified="2023-05-03" version="1">MAAHSCVHLRTYRMSTAKRASSMDSTGYDSSASTQSNQSSASALRGTFYAVYLYTNSPKAQLQQQQSETETSADEASQKPPATKPPKSQTKESLSLLATDLGAVAETDLRCFLIKKVARDLQDTRGNVDPMEMTLGEKATTTAMCFHQAFTKVASESEKKEQQAYVLCFIAPDDGTLDLYCTDLERFGKSLLPLLTDSEIDFKSALTSSLEEWHYITVLYMSRCVEAFAENIAVLLQAALNEAPVNVATENSRDKSDVEKFMEACNLRGLEGHKRDYEETESGCEPQAAVEIVSEDDRLLARNAEASPFCQCWAARLVKSRDDGPLILRRIIEGFKIRTIQNLNLVKRLVKEAENDHYALFNAYQFLKKCGYWEALLQRAVNEGSVVATPEGREVIELLQERLAANALAGSQVPVRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJK6</accession>
    <name>A0A9D4PJK6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJK6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034780"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF1">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="72020" checksum="E7EE12892857D098" modified="2023-05-03" version="1">MSRREYPVNDKHAPSGSELATSKTCCLDDLEGIKTWDAVEDVKQASPREDAVRQMCCPPLRVSICNKLLWGARLELRHTVREGLSLVSFSQRFLPRTNAQVLRATKLVQKLLTTHYCLTALDIDTDSFKGSETRFCEALRGNCLIRFLKINVSTFGLHKDICSAITSLPNLKEVECLTDCEFPVQFCAALATVLRTSTKLTAIRVPKLHMNGTSAIIFLPALVGNSTLEELSFHSSAISEARPEHRGAFATFLAEAKTLKKLAVGAYNEVRQLSLKWVLEGLLRNTVLSEITLDDFVVDADSADIMTEVLARNHTLRILNISILTYDAWMSRVGGSTMSCQTDFSAWLSALAGNETLEVVTLPLKIWEPEQWEELFQTLSAKARPFKLAIKGHCSERYLWEKLCLALRRTGMEEQVSFDTTLYILDKHEMIECKAFSKFHSFPYQDDRGEVSRLFRRLPSFTHVTSAHLEIWIPDVDEALSSDIAHYIETTSALKELHLTIWLRQLLPEAAKIGWAAILKSLRQNTSVNDLRVVTRYGAEALERIGKHPSLQQEVAHLLSMSEVEAATLLRTELKDMQSLDGFMRASGVVKDRVSCEKREDGHLRLDDLNEDCWSLVRRHLQVRDVKDPALTADTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJX0</accession>
    <name>A0A9D4PJX0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJX0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042877"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="45532" checksum="0271F751007B7D50" modified="2023-05-03" version="1">MTVNSVRKKGKSKRRRAPSTSQLSEKPAINASDTETASQSPCPKEVPRSANGTASSQPHASDPAPEDFTLASSRGARRRARTLASSPVLPADPAVAGTVLFKPSAPNGAFMQSSRLALASALSSRPGVIKVRVNSRRNIVAADVSSRECIEELLGVTELCGIPVSARLPADRGYSTGYLHGVEGDLTDDDLLQSIESSVPLVSAARNGNTVTLRYAGPVPPKHVSLYKLRCRVRPARPRPLQCLQCGRLGHATATCRRANCCLRCGRSHPSTESCSARPRCVNCGHNHPANTPTCRKWQEERKVATIMASSTVPLSRRAVRAMVQEANRSQLPTPPASAATRTYAQAVSGTPPPAPTPVPQRVDACSVLPSPASEASPASPAMKQSASPTAQLRDDPRDAIIASLQLTLRAVRKSTESHLPSSRPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKS7</accession>
    <name>A0A9D4PKS7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKS7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037683"/>
    <dbReference type="OrthoDB" id="6365503at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11921" checksum="B88344F8B696FB45" modified="2023-05-03" version="1">MTLTEGSRKRPRPCNDESCEFMPISKKINNLRIRVNSHDTVDEDTSSSGGSCPDHAQLASMVANGIDNPHYGAINRLLYEAHMQRQQRLLGASHQRLPEHCPGPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKY9</accession>
    <name>A0A9D4PKY9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKY9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="40" mass="5084" checksum="410BCBFE70C9A651" modified="2023-05-03" version="1">MYLRRETMIAYLTRQHSLLRGRWRTLRSDRERFLALRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKZ2</accession>
    <name>A0A9D4PKZ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKZ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7946535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="440" mass="48678" checksum="AFA7D663664384D5" modified="2023-05-03" version="1">MAAAKITYDAAGEDVVCPNVTQNIVVVSTPLEEHAKNYVRIKQIKVGEKVYNVNAYYSAGDGYCKGVIRNVDREITEKELNTMIVHSGNPTAMQAKRIKDTGSVVIVFEGYEVPNHVKFGGVLLKCYLYRRQVDVCYICAKVGHRADVCPTPEKKTCRGCGVENPTDSHECKAKCKLCGKGHPTGDRTCKQRYQTPFIVRQRRRERIEESRRERQLPGRFEDFPRIEERGDQRRSHGSTHRSESAGPRSQSGSRPGHLPAQTTWAQKAGGVKTQQVSGGSPTWQPGSEELKQMREENSLLKEMVMTLKEEIGTLRKALEATSKSAPVAMETSAGPVGRKRKAVGDVAVSDKDGFEAFRETMEKSLSEITNILQQLRVDVGELKKQSADHGKRLRALETRTDEVQEVTPQEKGQTPHLPSPQSKAGADGNAKFGSENGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLI4</accession>
    <name>A0A9D4PLI4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase UBR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042342"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000006">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000008">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PABC" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="1298"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="832"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1132"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1264"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="927"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7947257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1581" mass="170294" checksum="67DDFB8A19FA3DE4" modified="2023-05-03" version="1">MARDDRMVWEWHAREVWGENILLFLVQTVGRQLVEQRQYRPSRSRSSAPRKISNSEMGGNVGNPLIPPYASLQALNRGLLNDWNAIKTTIMAGYKEDESVASRLASGGSVPEDQQPHLVAQNGTALLDKFVHCLLVKCSIEMLDTLLTTLVREIQNENIPGRAAEARKVAHRFVRSVTRIFVILSAEMAPNTSRKKSMSGTTQPLMKCRRVFQSLVTLSVEELCEAADALIAPVRLGVARPTASFNLVSSCIDAIQGSEELFVVEPIVPRASQPEMVASPAEPPLGQNPLSARQPLGLRDALDDDEASVDVVDGAVGEDPDHEESERDERMEASEHDGTPAHEHNDEEDESAESSNMEEEEESEAGDTEPDTEELALLDEQLERRGGPSSSGGGPGGLGGSRPGSLAPQHLQWALRQRDPAGRSHVTSSGTGGLVYIDPGSLRRSAAVAAAAASGASSGSSVAAAAALAPELSPGTTAVGLARAFGAVLRQVADLLGSLQDNQAGLGLPKMLEVSYQDTLNMQAYLDFHLKPTWDWLVAVMDSTEAQLRFGCALSNHSDPSSTLAAPRARRGLFEDRLVAAGSLDGRRRNRLTTYGSEGVSARRDFLSYALSLMRAHNNEHFDSLPVMDVASLKHVAYVFDALIYFMRAGADDSDTPRDGFLLLDPWYAEDYNENEDPEEEAGGGGSAMQVDMDSCCEEDTAAGASGAAEGASVNTAAAGSNRGRRHPFFQRSDSTLCLGCQAPDPFSTPLAQALPLADRPQLLTPTATRQELFGAPRIPQASSGGEGGPSPLLPPRLGLSRASGSSLLTSTGRVAEVTRAPIIVAAPSSTRKGVLPTAAASTSTAPTQEGPAIIPTSSGLGGPSALPSTQGKSSVIVLAGSHRSQGQSSSDGHVPTSYSGAPSPAAEVTVTSSNTLPSLARAEGTSSAAAPSANLATAQSNSSSGIGSMSSSSRGGTSSVSGGSGSGTSALGQLVSHEVLLSRWQLTLELFGRVFVDDVGAEPGSVISELGGFPVKEVRFRRDMEKLRNSQQRDLTLSKIERERNSLLQQTFKELNNQYSAYSRRSMGGTPPLAMNRVKVTFKDEPGEGSGVARSFYAAIAEAILSPEKLPNLEGCQAGNRSLQYNIIQRLRSRERDKERRSGSAGGQATKSGGGLRYDAPPFVMPGEAGGSGQASNDHLSPHRQQLGQRLYPRVHALRPSLASKITGMLLEQSAAQLLLLLASEDALREKVDEALEIIVSHGREAETLLDLDVFSLGERGRRSTAARRSDAEEEEDDGEDCSPLVYQPGKRGFYAPRQGKCTPDRLNAFRNVGRIVGLCLLQNELCPISFNRHVIKYILNKRIGWHDLAFFDPLLYESLRQLVLEAESRDSSTVFSALDLTFCIDLCSEEGGGTVELIPGGREQEVTANNVYLYVRRYAEYRMIKSQERALGAIRMGVYDVLPNNTLEGLTAEDFRLLLNGVGEVNVQALISYTSFNDESKESSDKIFRFKRWFWSMMEKMPNQEKQDLVYFWTGSPALPASEEGFQPMPSITIRPPDDHHLPTANTCISRLYLPLYSSKAVLRAKIQMAIRTKNFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMP9</accession>
    <name>A0A9D4PMP9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMP9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="288" mass="32918" checksum="45C5EBE493BF9B46" modified="2023-05-03" version="1">MKQAALQKHTEELALAEESNRIIETKLKGALSQREALEETLARYRQEINQLSQQLVSSEEEKLSLRNKISLAEHKHKAEILQLRTDAIHQRAELEAKYEKALLELASAKADAEVAIKGTTDQKQLLVEKEKELEKKHHATRAKDWDRARRLESEKILLEAKLKEITTAKAAAAERLAESEKQIKRLKQAQDSQRQEFEEEVLTLKAKLKAVSSAREDTNKVAADNQVLQRRLALAEEELGKSHAALKDMQEQKERNREYRNAVHSYRSKIKSLKSANQEMHAEAGPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMT8</accession>
    <name>A0A9D4PMT8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMT8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048257"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039050087" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21720" checksum="568F438A671261E7" modified="2023-05-03" version="1">MAVVAWILAASLVVISSLPDLTESFSRYEIPHNLRNIRQQVLRRHNYYRRKHGVPPLKMSRKLNEHCQRRAVRLAKLDRLDHGGAKYAESIAAFPKEGNNGSLGRSVVDSWYSEIEQYDFSNGYYSKDTGHFTQIIWKKTRMVGTGSAVSPKSDRIFVASCYDPPQDNGGTYEENVPRPRVGRYSSRHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP80</accession>
    <name>A0A9D4PP80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP80"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7948115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="11884" checksum="0403AB5A7BEC4474" modified="2023-05-03" version="1">MVPSWRRISEQEEVVEKSKTRRCSSLSCLGWTHVADQVCGYPLFVAWVLGATGVGVFRCSRAVSWVATVLGDVPDQPSAVSPSRRTPGPSVTASCGTTCRECVSVPSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP86</accession>
    <name>A0A9D4PP86_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_008988</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP86"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041470"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038757060" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7947247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="155" mass="17430" checksum="52C1B2DB79F97E77" modified="2023-05-03" version="1">MAALRCVVAAILLAFFELSYGKVCENPEVTPKVYTTTDGLVVANIAFIAEFHFRCKENVQNIPLYADVKGKIVPVVKSPESNDYQVSWTEELNKAQSGDYLLRVYDEEGYGALRKAQRTGESAQGVTPLFTINVHHPGTYRGPWVQKVRYWSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTI8</accession>
    <name>A0A9D4PTI8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_020951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTI8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029363"/>
    <dbReference type="OrthoDB" id="6480153at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7952261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="511" mass="55172" checksum="8B16401DB1A8559F" modified="2023-05-03" version="1">MGAVTTPRDAAALQQEPLMCPSGECGPPSSKVQGRQEMEEDTRALTASGGRSPWRARLVLSVCCACMSGASFGLTLSYSSPALPDIRRRMPFSDSQGDWFGSLVTLGALFGGLVGGQLLNRLGRKDTIIFSSLGFAIGFLLIEASPLPIVMFLGRFLTGVSTGITAVALPVFVSEVSPPQIRGVLNTMCTIAITSGVLLAYVLGKWLDYQWLATACIVPALVVVISMPFVADSPRWLIHAGRSEEALQALKFYEGEDRAREEFESLQAAGTADERFSLAEFKLPYVYKPFLCVLLGMFLQQFSGISIMLLYTQDIFESAGSTIESTDCTIIVGVVQVASGFLATLAIDRLGRKILLLVSCFLSSISLVLLGISYHFKDTQGQAFLASYGWLPLLALCGFMVGYSVGLGPLPWMLMGEMLPLRVKGFATGVSTAFNFGCGALIAREYHSTMKLLGNDGIYWFYGTVMALGFVLVLIFIPETRGKTLEEIEVQFGKNSDNSADSREQPGLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTP2</accession>
    <name>A0A9D4PTP2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTP2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055281"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF146">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7955560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="224" mass="24955" checksum="B67F87E7C7B8BA6E" modified="2023-05-03" version="1">MCGAASVTTRHYADITTSKVVTPVRWPWSVAIHTSSRFRPEQFCGGALITDQHILTAAHCVESDSDIAVLKLAHPVNFTATVRPVCLPEGEDHFPTETEAYATGWTVRKVKEQHRTRRMLQELKMILMNEQHCAKYFDIGLPENVLCGSHIYGSLCEGDSGAPAMQFIDGHWFIQGVLSGGPLKCGDTTLPMVFSRVSSYVQSFIYPYLRAKTFNRKAQVCTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTV3</accession>
    <name>A0A9D4PTV3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GA-binding protein subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_021433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036450"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000025">
        <property type="entry name" value="GA-binding protein subunit beta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="63686" checksum="6ACADA81A64DB0AF" modified="2023-05-03" version="1">MVWPNTALHLDGSISPGPLPQEANASAWPQCLSDSDDSLGETPAFEFRVGCVDPNRSKLTRRSSYAGVLDVFQEEPVDDTMEISLPLQLVPQPSLSLVDLGKQLLESARNGETEEVRQLMTSGAPFTTDWLGTSPLHMAAQNGHVATAEVLLRAGISRDARTKVDRTPLHVAAQEGHLDVVELLLKHSADIEAKDMLRMTPLHWAVERGHLDVIKCLLRWGADVSATSKFEKSPLDIALDNDYVEVVRVLQEHVCNPTRTKETVEQTFILPISQVTKVPAGALGTAHKVLKTIPAATTALVTAGSPTIIQAKATGMVTPTRTVFVAAKAPNTTTVKRATVTKVVPAASVAASAGGTATSAAASASTTTITAEEMSSDQGSPSVLATLAALAEATAPNATTLSSNEAVQWLETHGITMLPADNSTIVASALEGGQTISLTVAMKILKDQQSVAADGTTSEVSLSNVATAGSQKVIAIVTDQSQIPSLVTAGAGQSPFVVVSGATLKAADGSASHMIIKGPMEPPIKRIRRVSIPDKVNGKSAAAPVVVTESQAKSPVDQEKDKLQRELEVLRKQAEQYKAQLQQKSHEAEQYKKQLEEMKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTZ4</accession>
    <name>A0A9D4PTZ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">N-chimaerin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_022028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037480"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="129"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7952354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37754" checksum="08895F83E0624D8F" modified="2023-05-03" version="1">MLQEGDGCYLVRESQRAPGQYTLSLRFGNACKNFRLYHDGMHYVGEKRFATLQDLVADGLITMYLETYAGEYINSMCAQSRYEDSPYMTLHSYQRQLRQKQQQSLRMRHHRQPPPAAEQESHEYDKPDEELDCPLLDGIPEDINVQDFEKPHAFKVNNFKGLPWCDFCGNFMWGLIAQGVRCEEKVPNDCLPDTKYVKRVFGVDLTTLVKAHNTPRPFVLDMCIKEIEQRESNKVEEKLEAMKEAVKSLPPAHYQSLKYLMSHLQRVSEHQKKNLMSPKNLSTVFSPTVMRTPDIMGMGLDQMSAWHTESAVVELLISYNRTVFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUE9</accession>
    <name>A0A9D4PUE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUE9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042304"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12621" checksum="1CAAD1206E049BD2" modified="2023-05-03" version="1">MRNNIVGQDDTFEGFVNDDCDDIVCEQADTDEAIVAAVQDRGDEVSDDDTDEEDRTPEISSRDALDYVSKLKLFCAQNLSKKALQHIIAVEDEMVHNAVKARRQTKITAFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV42</accession>
    <name>A0A9D4PV42_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_007787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057747"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF5">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="10">
        <location>
            <begin position="237"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7956281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43184" checksum="02B50F6B8812ABC3" modified="2023-05-03" version="1">MDAAELGLNPWSATASGHVLLEDKGHRRRQRLLMVSCGLATLVCVATVAVAVAVVVTATTPATTGTATSAANTTPAPSFVAEVDRKALEVPSRRREGPKGVAGLSRRKRPEKRIGRQTTLDPRETWATFLRHSERTQTARPKKKVDPSFLRMEGPQGPPGPRGPRGPPGANITREDMFREFKGLLREAAERRAQVMAEMQCKNTTNCSLPLPGGANGSDSLLPWLPPLVEIDRASMLPRAQSGFFWELSEEVRARKGKELRLHPFHRPFAEGSFERGSGLNATRGMFRAPLSGLYLFFATAFATRPMSARALRKQLEISANGASLVVCVNARCQKNLSLRTTSEFSDGENTMSLSVNGPLMLRAGQVVSLWFHNRTPYQITIHEGSQFSGFLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW24</accession>
    <name>A0A9D4PW24_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW24"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038523"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="443" mass="49946" checksum="8ADD7CDD73390F90" modified="2023-05-03" version="1">MESLHYPWRDKVDGMVEHEGEVEQDRLADDGPSLTKLPDHVLIKICQYLEPFDVLSFGRTCHCLNRLTSSRFLWTSLALSWCRGLWNYLPGEAGYGPEEPKQWLFHLLRLCRERQPTKVQTVSFENGETWVRTRNDRFTCKVSMLAWAYEAMNNRKSPFVLNCVWVDDIALFKRLSPKIHFNVSELTLDLKSARQLATLGGARAHDLRGPKQPHIDARNYISRKPPSSARWCEDLFPQGPEGSICPLLVCPSTDGYALESSGVDGLVTCACYVLERHLARACLRGQMTLGKMAVMIKDACWYLHSTYLDHKRTAEQKWPNCPVAHAIVSMSEGGLPDLAAWQPFLNPLGLQWREVMSQCAALLKEHGTLDAIVDMARIRWRQALLSDIEAVVGHSGKTFASRINLTDCDVIGGDNPHQDMASAAFVSPSGALVMWQLLGQGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWX4</accession>
    <name>A0A9D4PWX4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_015666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038419"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7957148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="767" mass="84830" checksum="D02513F4F6969C2B" modified="2023-05-03" version="1">MAPSSKNAKPAPYGHRFSVSRIEDILPELSTAHKEKVCIVSFIGKTTLKGSCVKASLIDDVLGNNVLEPELGVEDDTGNDDIVHPTSTLDVSYVHLFRTLDNIRVNCQQDVSDTLKSCPLSPEWIQNGRPCSPRVLFVFLTCPLEGSTSELLDVRVKTKPSKLSPIKKLEHSLEDQVYRILRKSRVITNISGNSLFAVPANQEFVYVRTTSSVREDMVDFFLQKLKDFCSPDYDDALSEDFLSLSLGGADEASSQEHSFPAFLWQHIEMALSKGFDDNVGRHPVPADFELARAFQMFSTHARGPAFQRYAQQLKEDCDLVWKSGRQMCEVLSLTGNHCINPVHRTPENADEVSIEECPLLMPHRSQVVLVSTCNCGRQQSKREDPFILKAWAAANYDFYLRVSADCCGVLERINFPAFEPSASDQDQAAADEAEAPHVELEPPRSRSRAKSLSHSESSSRSASPLSESDFSSQSPVSSNDSDSASSDHDDSDKSISLSDARTQQTDDPDDDDAAKAALVPSNTEYLPGMLHSLSPPGLLPSYSSWSLVCLGPSSLYSHNIGIQDQLGFVAGTNFLLPWDVAVKVDKDRWPSLWEGKRAQTWKGKKNGKGDGMQFTVKVFIGVEYECHHGHRFMCSSPERMLRTTSTGLVKDNANKIANSHMPLYFPCLCRSAKPQVAQLMRLHIVTPKAPVHVTLNPRVQPGHSAPVFFPGNKEPVKLSQSAYWVLRLPFVYEGDAGPYLPPRDGVPCEGARLLSGCYGIVEQAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX65</accession>
    <name>A0A9D4PX65_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039920"/>
    <dbReference type="OMA" id="YKQRDYT"/>
    <dbReference type="OrthoDB" id="6492000at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038693747" description="Phosphatidylethanolamine-binding protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21028" checksum="AF03D64E682A0C64" modified="2023-05-03" version="1">MESKYAALLALAAVVVLVQPPFCACAMNEDLLLSFSKSEIVSDVIAAVPERALNVSYPGGATVNLGNILTPALTAHAPDVNVVGDPGHWYTVILLDPDAPSKSDPKMRHWLHWLVVNVPHNDTTTLMKYAGPTPPPGSGRHRYVFLAYEQKQPVARNAMSGFGKERAKFNLAAFLEALGVNQLVAANFFYAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXQ3</accession>
    <name>A0A9D4PXQ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXQ3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32722" checksum="06D5C1282C09B109" modified="2023-05-03" version="1">MNPMEDDTSSLALGPAVLTTEGSLAEAAGAPISSNIPPPAPRQPLPSEFDCPGRTNSPSTVKHRAQSTYARLPTSPGFTRLALATRLLSLETALAQRTSTADDVVADLAARVSVIEAQSSRQQRVSTSVEQNNIGRAQSRFSGAHLLPPTFDGTTSWAAFLAQFESVATLNGWTVQDKAQVLVVQLRDAAAEYLDYLPQGIRSNYEALLYLTQLKHVRQGRRGLHELAAYIDSLSRKALSGCPTATMDLIAANAFVDAINNRNVQRFVRLARPTDVPSALAVALEAEIQERSQAAEDPYRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYF8</accession>
    <name>A0A9D4PYF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYF8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044989"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="244" mass="27030" checksum="D9C6EE69C76A6746" modified="2023-05-03" version="1">MKLVVSPLFVHSALQTPFSRGIAQTFCALSAGPSGQPVYCDMDADGGGWTVIQRRGQYGNRVFHFYRNWTEYANGFGNPSDEYWIGNHALHSLTSSDEEMALRMVLSNDAKDSVSVDYESVRIASEADLFKIKVGTHLGPEGWNAFTVNGQNFSTFDRDNDAWPQNCAVTFRGAWWYSACHSANLNGLNLNGHHDSYADGIEWSARGVGVPGVQYYSYPSASMMIRPASFLLDRRSSITEPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYQ8</accession>
    <name>A0A9D4PYQ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein t</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_007679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043232"/>
    <dbReference type="OMA" id="TPAFYTW"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14619" checksum="7718FE649F6DFB93" modified="2023-05-03" version="1">MEKYPSLLVEGDAYPPPPPRMQLAHALSLLKLALIALVLLGVNPFTWMGYPTPAFYTWMVGNKLYSCLMLFFVCGAIESKLVSTGAFEIYFNDVRVWSKIETGRIPSPPELFQIIDNQVFLKSSTLGLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ92</accession>
    <name>A0A9D4PZ92_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ92"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027309"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000207">
        <property type="entry name" value="Protein CBR-LIN-10, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="391"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="572"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="663"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="753" mass="81614" checksum="C8BB8B137C59FFEA" modified="2023-05-03" version="1">MHPSSEASSDTDEVARLFPKCRGRHDGHSQDDDDEADSLNNNHHPMEDGSVVSAYDTPSRIEIAGGREIFCKSRSRPKRRQRDAAEAWEDEPLVYEAPVCGAEVYDDIDERTTNAPARLIGNVPIAQYEGSPRRYGPRPGYPQRVAADAQPEADENTVCGSSYVGQRLAGATPSPRTPPSPRPPSPRLGGTPVAASPDPGSTGGGSPRRLSPRPRSNSSTETGEQMDEQTRNLTLSPDGTDCESASEAMSLAGSADAPLAMPVLEDGLSSGHLSDTEGSVGGGTAATFRRCGVRCDPRDPTGHPTQQAPGTQELWPCRKRGCPTCLGAQSTREDQAPDDDCDTDQETDRLLGAQRSDDRGFFDDKAQNSVGKKKNTSKEVLVHEPAVLIEGVLFRARYLGSTQLVCEGQPTKATRMIQAEEAVSRIKAPEGEAQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRSISYIADIGDLVVLMARRRTLEDDAGGGSKLRRTPKMVCHVFESEEAQFIAQSIGQAFQVAYMEFLKANGIEDSSFVKEMDYQEVLNSQEIFGNELEMFAKKERQKEVVVPKHKGEILGMVIVESGWGSMLPTVVVANMAHNGPAARCSQLNIGDQIIAINGVSLVGLPLSTCQAYVKNTKHQSVVKLTVVPCAPVVEVKIKRPDTKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINGQSVVAVPHEKIVNLLATSVGEIHMKTMPTSMFRLLTGQETPMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZF5</accession>
    <name>A0A9D4PZF5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Importin-7/11-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZF5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040571"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin-7/11-like TPR repeats" evidence="1">
        <location>
            <begin position="276"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Importin-7/11-like TPR repeats" evidence="1">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="618" mass="69992" checksum="A66E41EB5F93BB7A" modified="2023-05-03" version="1">MEAAQIKMTFFTYATVTEMCRRLVLHYFLLTEEELATWDNDPEGFASDGGGEAWKFCLRQCSEVVFLTIFHEFRETLAPLLLEMIQGIQPAEGSISFQAMLNRDAVYTAVGLAAFDLHDELDFDNWFLHVLIPELKVSEPRYRIVRRRVAWLIGQWVGVKMSPELRPVLYKTLIDSLDPSEDLVVRLTAAGAVKADILCTRFVVPKNVRQYLESYVSLLYKLLQQVTECDTKISILHVTSFIIERVGSQIMPFAGDLVQYLPLLWETCGEHHMLRCAIVTTLVQVVNGLGAQSERLHPFLVPVVAFGVDVRQSPHVYLLEDCLDLWWALLANTRSTSVELLQLAQYLFPLFELGTENMKMCLQVVQAYILLFPKEFLQTYGDRLLKATTDLVCDLNREGMLFIMRMVELVIRVFPEQGPQLFYPLLVHALEECLEGEKASMLTSVCLSIISRVILHCKSCFTKLLQEEAQGKGCDAEEVFGNLLDKWIEKMPLVNPVEREKLLALTLTSILTSNSNESGFRFLGAILFVYSLSRQDPVHTVALRDYLCSQMRSLRESLGEHNFEELMGQVDVETMQQLKTYLEGGNQSNGGGAVHAALFASANLNSTTTHHAPNTHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0A5</accession>
    <name>A0A9D4Q0A5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_010702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0A5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049714"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031738">
        <property type="entry name" value="JMY/WHAMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031808">
        <property type="entry name" value="JMY/WHAMM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF10">
        <property type="entry name" value="WH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15871">
        <property type="entry name" value="JMY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15920">
        <property type="entry name" value="WHAMM-JMY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JMY/WHAMM N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="JMY/WHAMM middle" evidence="6">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="241" mass="27485" checksum="1F75B1C01437019C" modified="2023-05-03" version="1">MEERQDSLDGWVAIRENLFEPSASLQSATPEGERHACDRDTCAARAALLSSDALHDIHKQLVLMCPALENSFPLTDSQTKGSWNFLRFFSKKNGVCERLDSSVEGKVCRELEYYFKQALDATGKRLLFSLLFGEEDYLTDYEEDIQELRLRGLERTLERAYDELNEILSLRSLSETMLNLSTVYALEDQVVLGPFLELREVAAERSRALRLRADDGRLGPRVRAEATKELEEWDARAQSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0Y9</accession>
    <name>A0A9D4Q0Y9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0Y9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045218"/>
    <dbReference type="OrthoDB" id="6507910at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="13240" checksum="9EF0BDD1B45C90BD" modified="2023-05-03" version="1">MFRCAAGKDVCIPRRLTCNGINNCGDDSDEPRHLSSEPCSVDPESIWGPIVFCTILVAFSGIVVYVIVLDICMARVSFSSSSSVSGDTTSTDGDDSGSGDAALTPLPEVDSDQAVLLHNAEIVVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q143</accession>
    <name>A0A9D4Q143_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine rich superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q143"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047122"/>
    <dbReference type="OMA" id="ETTMPFN"/>
    <dbReference type="OrthoDB" id="6513303at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039064472" description="Glycine rich superfamily member" evidence="2">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="44177" checksum="39185C399417FD28" modified="2023-05-03" version="1">MRRAILLLICVATAYGQQKGGATGGPIGVGPGASLSGLSGPAGGGGPNGMSGMGPSGPSGIGGGGGAGPGLAGTGPNGISGGPGVAGVGMGRGGPGGPGGPGGPEAGVSPSIMFGEPEDEGGEEGGAGLIGFGPEHGQLDLFTLLLRQIFLAYGADPLRLPETTMPFNSILRMSGTVHTYNSRVFGLSHVRRTGPCFVTADQSGMRLGLDLGIKDVFANSSATVTMANKNIRKQRVHFTVIVRKARAILEVAQTGAHEIHVTNFKILFLQGFKLFLRPDQPSKRPLFRAFLRAAQAFLERSVKRRLEPLVRKAIDTQIKTVLAYLNRQAELRPKPRLPPELFAGVAEGIVIGGPSGPGAGPGGPSFGPGVGRGGGPGVGPVGPGGPLSAGAGFPEGGPSNGGGGAGSSISGVGPTGPGPQLAAGAQLSGLSGTIGGGSGVGQQKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q150</accession>
    <name>A0A9D4Q150_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_014005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Rapidly hydrolyzes choline released into the synapse.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q150"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055912"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039741127" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="11">
        <location>
            <begin position="42"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7962032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="588" mass="65952" checksum="D7E5731BAFEEBEB8" modified="2023-05-03" version="1">MVCAPTSLAMLLLLVAGVPVRPVAARKGHQHQQQQHHRPDPLLVHTAKGPVRGLATESPTGKPVDVFYGIPYAKPPVGRYRFRHPKPNDPWKGVLDATVKPKSCFQTVDTFFGDFRGSLMWNANTNMSEDCLTLNVWVPRPRPNASQPAAVLVWIYGGGFYSGTSTLDVYDGRTLVAEERVVLVSMNYRVASLGFLCLDHPEVPGNAGLFDQLMALQWVQENIAAFGGNPRNVTLFGESAGAVSASMHLLSPLSRDLFSQAILQSGTAIAPWGVHDRHTALQSALRLAETLHCPHDEHQLEAMLACLREQDPEMIVNSETGNFGVVEFPFVPVVDGAFLDESPQESLAARNFKKTNLLLGSNRDEGTYFLIYYLTELFRRDESVYLGREDFVRAVRELNPLVGELAQQAIMFQYTDWLNPEDPIKNRDAVDKIVGDYHFTCSVVEWAHQYALAGSQVYAYYFTHRSSVSAWPQWMGVIHGEEIAFLFGEPLNKSLGYRPDEQALSRRMMRYWANFAKTGNPSLSEEGHWERIYWPVHTAHGKEYLTLAVNSSLVGYGHRAKYCAFWQQFLPRLVNLSGGYLCATTFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1W0</accession>
    <name>A0A9D4Q1W0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_018507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1W0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044185"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="20082" checksum="AB590D0CE16260ED" modified="2023-05-03" version="1">MLIFKDKISGDEMFTDSSKYKLVDDCIYEIECHHVTRKQGEIQLDGANPSAEEVDEGTDENVESGLDLVLNMRLTETCFTKADYKNYLKSYTKALQEKWKEEGKSAEEIEDAKGKLTTAVKKVLPKLDDYQFFIGESCNAEGIVGLLEYREQDGGGEKAVMMFFKHGLDEEKMWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q234</accession>
    <name>A0A9D4Q234_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q234"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050396"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000336">
        <property type="entry name" value="Aldehyde reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="483" mass="53133" checksum="203AC01416977A21" modified="2023-05-03" version="1">MASRDVYKHPFRSSELKRRSAAKPIRASPDERDVVLVTGATGYVGSHIVKLLLEEGELRVRATVRNLEQEDKTKFLRELVPDAKHPIELVQADLLKEDTWKDAVKDCTYVVHVAAPTPHSSLSKDNDLLKLAVDGTKAVLQACADSGSVKRVVLTSSISAVFGSALSEREGKPFTEADWSNAESATLDAYGKAKTLQEKAAWDFVKELPEEKKFELVVINPGLCIGPLLQKTTHGVPTSVLLIKRFMDRSIPLVPPASLSVVDVRDVARAHVRALTASGAADNRHIVTNQCISVKDMATALAKEFKPHGYSISTAGAPYFLMWLNSLVDKNSKLLMSKLNKPSTYDNARMREVLEIEPRDVQQSILDTAYSMIQLGVVKKSKKMKKQELSTEGEGHVNGDLNGEKADDEKDEKKEGDDEEKAADEKKETPTEDTKKAEEVTKKADEVIAEPPQNKELEPEDKVEKANGDVAEPPPQPVEVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q293</accession>
    <name>A0A9D4Q293_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q293"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057570"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="461"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7962680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="749" mass="84289" checksum="4921AA16762086FD" modified="2023-05-03" version="1">MDNIHSLDPRKQELLEARFLGNRQLCNLGQGGAYLGQTSQSSSGGAMAAAAAAAAAAGVSGPLAGVPASQLLAHVSSSGSSNNTNHNQDSNMSNTSLGSQHSDKELEPQTPEKHLRTPPQSERKRKRMKEDTASTGVKGARTTVPENAKKINEYFKNQGHSPSRFGGARSPVPQGYCLGGSPLVSPLTSALNSVDYSGLMAPPQRPAHVMMRQVQTDLTINKIKELESKSAMDLEMRDNRIDELQRGSEELRRQIQGQQKVIQKQEEQLLKCIDVTKQLLIEKSAMEKKQSRQKCMQNRLRLGQFVTQRQGASFVENWVDGYAFNDLLRKQEQITSEREEIERQRKLLCKKKPTTGQPKGKGAVASNNGAGAASSGLANGEFVKPESPKDLALLRLSWYEYYEQEEILKLRQVSLKKEDTDLQLELEKLERERNLHIRELKRIHNEDQSRFNNHPVLNERYLLLILLGKGGFSEVHKASIFLINCFLVCTCIFFFIFALLNLMPCFAHLQAFDLKEQRYVACKIHQLNKDWKDDKKANYIKHALREYNIHKSLDHPRVVIVLWGVVHALKYLNEIKPPIIHYDLKPGNILLGSGSLSGEIKITDFGLSKIMDDDNYSPEYGMDLTSQGAGTYWYLPPECFVVGKTPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATDVEFPAKPAVSNEAKQFIRRCLQYRKEDRIDVFSLSNEEYLKPNYSKHGRQASVSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2S6</accession>
    <name>A0A9D4Q2S6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2S6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="15990" checksum="DBF1DEB8FD00E1FC" modified="2023-05-03" version="1">MVLFVLFTGATTGRLRRLLGGVVSARRSHPTAWWILSGVLEKLSSPEDSEVATESRVPGGRPEDDATQLRVPVQPLDLGRLLGYNTFIAHFDNASARLHLRAGRLPSRSSLSSSASSSSCGEAERATLPRGERRDDGSRSCRTTTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q321</accession>
    <name>A0A9D4Q321_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q321"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030808"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8647" checksum="A25388322A8FCA97" modified="2023-05-03" version="1">MADGGTKRKALDIPTKRAILTELSQGVKNCELVKKYGVCKSTISTILKNKDEIISADANSTDKKRLRRATYADCDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3M6</accession>
    <name>A0A9D4Q3M6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3M6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="16002" checksum="43657C98D01502CC" modified="2023-05-03" version="1">MLVIQRKHIEALHQLQQNDGLNASNKLSPAHVEYHRQSLRLAKFQQPYLERFQGSTATVNLPLPKGAGMELMAMQVATGKPVVQDSWCMSVISLVFVPKSVSYLGQAMFEADLCSYICTSRLNQDPMEMLFQLYKAKRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3V5</accession>
    <name>A0A9D4Q3V5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3V5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="430" mass="47520" checksum="824B70E82ED3D808" modified="2023-05-03" version="1">MSERECRRGRCEIEEELSRYCVETANRIPVNARHFIMARVATSGDPERGGRLAQASCPGGDKDDHRGALGGRHSTCGRADVPGTTWISCGAPRSPPVEFCAADCRHDVRGGTPGGCCCYAVPTRPSAIVPDRGPTLHEHVAFVTPIAPSAAPARDSLRLLKANIDPAAHDIRDVTLRQTRYGLTVLAHSRDTLTNMRQAIADNAITCAALSMRIPEKRNPHVRFSGVDPDITSEEFISRVAERNTHLQLDADKCKVRASFKERSGTSAFIVEVDPDAFARIMRQPRLSAYADDTIILVPAPTRSALGDLASEVLRRVASWSRTVKRFPRRRRDENDGVVGVSLYDYPARHTQRQQAINDDIPQEWGERRTLRAAQRCMGLNLTRVGPDKHRAVREKRSQKVVKTAGQIVLPEIAEDERVPNAVKGPVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q497</accession>
    <name>A0A9D4Q497_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_001534</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q497"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032106"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000001">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="16">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7967657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="391" mass="43594" checksum="E2C0949BA1880CE0" modified="2023-05-03" version="1">MEVVNADSINTNLEAMLRENTDLSPAVASLQLLLEFIENDDYTTIQGMEDNLQKVIRGICTAKCSITCVRSACELFVRFATRTALDCSIDECKKKMSTRGRTFLEKMRAARSKIATLAAPFVQDRSTILTHSFSRVVRDTLFAAAEDHKHFTVYVTESAPDYSGRQLYEALEERGISVTVILDSAVGYILEKVDVVLLGAEGVVESGGIINKIGTYTMAMCAKEKNIPIYVLAESFKFARKYPLNQKDLPDEQKYPSDRRNGNTDLSKEHPMIDYTPPAYITLLFTDLGILTPSALRQSAMVNCAVYGCSNRTRNSLNDENFQRVGFNVVPKVISGQCAKITELSSKRRALWLSRIRREDLDESATHYRVCGAHFITGERGSSIKCISSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q657</accession>
    <name>A0A9D4Q657_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein PET100 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_010640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q657"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9709" checksum="70BD255BD2BB44D8" modified="2023-05-03" version="1">MGNWQLEVWKMAVYMTFPVALFYVFNQPQLFEEWVVKKKRECFPPADPAADQQLKEFMETFKAKKREELVKELAAVSDGSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q683</accession>
    <name>A0A9D4Q683_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q683"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031343"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044305"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="338" mass="36936" checksum="B30047383359F2DC" modified="2023-05-03" version="1">MSRNRKPLTLGEKLRIIEEAEKRNGATKASIARDLNIPESSLKTILAKKDSILLNAAKFGLNRKAAKDGKYAAMEKALVEWLRQARSSGIAVDGAILKEKAETVALRCGIDDFKASNGWLDRFKKRSGVVYSRCCGESAQLQPLDAGVIKCMKQKYRKFLVQRRLAGMERKQLDKKLSVLDAMHYSASAWDAVTPETIANSFRHCGFNRSGACSTSEAALPVDDEPEFGSLELPGSFADYVGADDDVAVCSEVSLDDIIETVRPDTAGTSDEEEMDDAAEASMSVPTYADVLCYVDHIRRFACARDEIGDLLPDVAAIERKLMLAAAGRVRGSKITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6I5</accession>
    <name>A0A9D4Q6I5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6I5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="97" mass="11161" checksum="8D1146C72FFE17FD" modified="2023-05-03" version="1">MRLCGEVLALSSMVPTKLTRHLRTKHPSYQDKDIEFFETKKRQLESQKLYNPNKLASFADAIKASYMLSYHVAKQMKPHTICETLLMPCMKASSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6I6</accession>
    <name>A0A9D4Q6I6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046553"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="23135" checksum="88E159D00B83B947" modified="2023-05-03" version="1">MAAAFFSIVSLRGGFVRFEGADKDEGAVGAIACEVAREFSISKQTVSNYLNQKEKILEAAEKVSAGTQKNFRDGSYPKLEEALNLWLSAKVAKKIPVSGDLLKQKAETLALRMGITGCKFSDGWLRNFKKSGKSYVVDVLSAISILSDAWKAVTQETVHNCFRHAGFVNTESGDEDSATDLDPAVETPPTAAADILDDLRASGVDIPGGDSTPGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6Q2</accession>
    <name>A0A9D4Q6Q2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6Q2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7968588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="568" mass="60598" checksum="21D8990651A284E2" modified="2023-05-03" version="1">MGENTGSGAWGITHRVHRRPRGPTIPEWTSEAMPRKPSGKIMKKAGKDQRSLQQQEEIPERQTVSVIGDRPLTVSVIGEWDPSGLPVIHGRDASQPNGKNRTTKNWLLNKAKEAAPVAADLPEPAATTPVNTDDAPSRSHAATSEDEAMDATATSRKWGREEDAAMAASAGIVAAPPAAPAGKRKKNKRKARPKRRLPAREYETSAAEAPTAPRPLNTTVAVPGPCPGPLPAEDDLVTVVTKAAQRRARALEAAAVAIDPAVVGTALFRPSAPGGSFSGSPRLTLAAALAKRPGVLAVRVNHRLNIVAADASTPTCLSELLAIRELGGVPVTAREPADRRSSTGFVYGVDGDLTNAELLAGITWRERPSVRLRFAAPLPPERVLLLGLQLSVRHVRPRPRQCQQCGRFGHVAEACQRKGACIRCGPQHMEAESCKPRCEERRVATLMAVTPTPLSRRAVKAAVREESREVRSYAAAVKNKPLEGNTMDPGLQRPSPAPRRSLLPTASSPRSSLPAAPPAAPAEDPRDTLITNLLTTLQAVMQFLPEEHPLRATCLRAIGTRSGAPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q839</accession>
    <name>A0A9D4Q839_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q839"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034501"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="64" mass="6825" checksum="4C5D315979204565" modified="2023-05-03" version="1">MLIAVDWPAANLPLRVSLYSALEMVKASWAEVTATCVQNCFRKAGFADVGADADPEEDHSGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q984</accession>
    <name>A0A9D4Q984_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_006160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q984"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033756"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13359">
        <property type="entry name" value="PH_ELMO1_CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="322"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="732" mass="83527" checksum="4763265C74C85A5F" modified="2023-05-03" version="1">MKGTRQSKPGTMSAIKDAHIVKIAVEMDEQVPQLIEFDQQRPLTAIIQDLCNTWALAEPEQYSLQFSDNARSYITEKNRNDIKNGYVLRLTHSPAKTAQDILDKLHSNKPDDMRAALERLQRLSSDYTFALEFINKQGHQLLINMVEGGTYTGDHLALTLQSFVELMDHGIVFWDILEPKFVGRVANQVNVNTTQDTRTLQASLSILESLVLNGTGRYAMVDQEVTLPNLIMHMQSSSVEIQQSAVALINALFLKAESTTKRKTLAATLSSRHIRNVIVTAVLQRSQQHVGTEMAHQLYVLQTLLLNLLDERRVGVDPNDAEARERILELRRIAFDVEADGTCSTTSGGRKGGGYAKDYKKLGFQNHTNPIEDFSEPPGILALDNMVYFARNHTESYTKFVLENSCRADEHECPFGRSSIRLTRLLAEILKIGEPPTEQGKTYYPMFFTHDHPFEEFFCIGIMLLNKTWKEMRATTEDFVKVFSVVQEQISRALATEPPLMSLDKFRSKLAMLTYSEIMNLWQQEQSTREEWESQARPIIELREQVTPEIMDLIQQQRVQFLCEGTLFTKYSAKGHRIKDKFWYCRLSPSQKVFHYGDCEENATPSLEELPHKLPVIEIRNLATGRECPYMKDTRKAKSTASLAFSLIPDSNQEPLNFVASNEKIFDYWTDGINALLGKKMVSKETKNDLETLLSMEIKLRLLDTEGVDIPESPPPLPKEPPNFDFCYEFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA58</accession>
    <name>A0A9D4QA58_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA58"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043346"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="722" mass="77013" checksum="6BD3C124907F4C8D" modified="2023-05-03" version="1">MSTILSTRVLITDIAFGSLSPLSGPGSCDSVFCHRHVSNAAVITATMAEESPPSSATPVERARRPLVRTSSHRRSESVACTRMLWNLIANANTVRLRHEQAQRLCKVVGKQPTALHLPAPAAAADAIARGLATSGASCPTVSTAVSSDTSAALQTALPGVPNTVGRPMTFPRSSPTRGTYHCRDDEGASRKMQAVATERATVMSPTAPPSDTVAEEQPDTPDADGTNENEFQTVFSKSQKRRQRASTAPRPVGNIGPPTAPAATPAAHPSTARVVPEPAKPPTATQAASTGVLAAADTMLRSALSPLDSGTVLFRPANAGASFHRTSRLAIAQALSALRGVKEVRVNTKKNIVAADASTAEWMDRLLATSELAGIPVTARPPADRSQSSGVVQGVDGDYTDEALLAAVTSEVPVIAARRQGTSLILRFASPFPPARVHLFRMAFKVRPCRPRPLQCLRCGRYGHITAACRRLERCLRCGDHHGKDASCTSKVKCLHCGRPHSADSAECQLWQRERRLATIKASSLTYLPHREAQAALRSSSSGTNGPQLNQTKGKSYAAAVGAPSKDPRPTGAQQREPPAGPKKQGSAKPRPPTKATSQPHADQENANLRLLLRAVADLLHPENQLRSICLQAAWLTRETGTTGQRSLTPRVLTTCRSSSHRREGRSQGPGSAEQSIGELSGSSSKRPRRTRISWIWWQQQRKQPQSSPGCPRTILCQTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAL8</accession>
    <name>A0A9D4QAL8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAL8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="526" mass="57214" checksum="2D89297415BABBE8" modified="2023-05-03" version="1">MAPPVPALKCLTSEQKVQLVREVEKGGRQKSEIARQFGIPTSTLSTVLKNKDAVLDGFEKSFSAKRKRNHIPVVAPATDAEIVDLLGGPDEEEEPLDEQPREIPTVAQTQEILRLLRNRVECAGGDHDLIICPNKFEQALLAPSRSTRQSQLTDFCELNFETSLGWRRGNTSFARAKNLDDASSSSVLKSDESTSSPDSLMLITSSKSTVDALDSRETRRLLGTPTRDDDADTRAQQPETFCGERKLPRATCQHARGCASACLPFPVKLVDPPTHVTQPPLSRGTRGPARSPAARAYHVDGDTATAAPRALLLFVVRCVCIRTASLSVPAARQSQEMDDGNGKRKRKTITIEQKAAMLKAVESGVKKKKHYVDDIEQQRSSHRCRCTIANCFRHASFGVNSGGDSEDIGAAANEGAAGDQDLASWDALLDARVVPDCDTFCTYVSADADAVTTEELTEAEIVRAVTGVVNDDSDECVDDSPEFANPMFGAHDDGEDGLDIAAAAEKGIIRLRKTRQKSIKDFFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAW2</accession>
    <name>A0A9D4QAW2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAW2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="13047" checksum="0D625961014D3FE6" modified="2023-05-03" version="1">MPRGHNTFGFRTGFVTAELAETSEDGDHKRIDDAFHELSSLFPAAVLPEVSADDFEEADCNVQAVASLAVEDIVAAVVGTQDAQADCSSGDEDRLDEAAATRAYSAAEVAAAFGSIHCFCGDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAZ4</accession>
    <name>A0A9D4QAZ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055557"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="20322" checksum="9B4D8E803FDEBB42" modified="2023-05-03" version="1">MNSPVLWNIFVFMRVLYGGILLGTVREYINQSTKIVRLECHLRFNYECLSNNVVPRSLYCKTLVDTPYGRKLARDFSRNCLKARIQDKQQIHQLRERAIRDRRKAGGKVHVPEDLHLPGDVVQVLGLGPKFGVQKQRTNPELLTVVRQVSRRATEGVWSQGGATVHRAYIRGVGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDK9</accession>
    <name>A0A9D4QDK9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDK9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035433"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="176"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="270"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7976336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="680" mass="73929" checksum="3415381DDAE086B2" modified="2023-05-03" version="1">MFERKNLEPDGKVQPPVFVSTAPAQACPPSIKDARGATFKETAGPYAEGDTVRLTCDIETCDHDVTLTWYHNGTQLRSVRGTVATSDGGWKNLVTLGPLTRRDLHSNATCLATSNVSLPGFATVLLDLYLAPTNVTIWSWPSQQTDNTPDSVESSSAATKYSPPAKNVTIATTFGPGLALSDRDAKGREATATISFGSPSPFSKSKSFECEATGSRPAANVTWFLDGIAIDPSFSRSVSAGNVTTSMLLLPASAQSGQLLECRAINGNLPESRGVLSRFLKVDMSRLNSSHIVEGADVYMECSVLAASKVIEVIWRHEGARMKGLAGDDDPSDAFVTSRYLVIRGLTAEQSGRYTCTANTADGESVESVPLELRVRHAPRCGVHRDRVLTARPNEQLNVTCDVSADPGEDLHFFWIAEDDAGNRRHVTRTEGTSIRTQDAHSGEGLPKLRRSNQLEVLVDAHLFHGTLLCWARNAVGTQREPCRQRFQLRRERASSLDCTVGNYTDTSFSITCSSRRHGRAWTGEHRDAKTTKTRLRIELFDATAGNRSVRAFWVTTTDTGREPLFLTGLKPATDYLVLVRLDTEANAFATYVRTLLPAQTLKEREELASTRNTATPAPKDTTIIVIVCGAAAATLGLAAAVGAVLWFKYHRRRSRLLNAAAALKHAEHKAYLASDASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDN7</accession>
    <name>A0A9D4QDN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048066"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7975915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="396" mass="42336" checksum="E0700268FD379AF5" modified="2023-05-03" version="1">MNGVLHNNPDDLCYHNKPQQLVVNESGPNAPIRLSVLEGEPTSLPCPIDTATREPITAVWFHVATHAHQEYGGSPYYTSGHLQAKRVYAIEAPDWSSPTAAAGGTTGLVDGTHWKQPSWSGRAFFSLLSDPPALRLNHLERPESGSYVCNVTYRDNATSAATVVTESRVDLFVAGDHDVALTWFHNGTQLRSARGTVATSDGGWKNLVTLGPLTRRDLHSNVTCLTISNVSLPGVATVLLDLYLAPTAVTIWSWPAQQTDTPPGSVESSSAATQHSLRNRSATIATTLGPVLALSDREIAVATSFSSPSGFSNTKSFECEATGSRPAANVTWFLDGVTVDPAFSRSVSAGNVTTSMLLLPASAQSGRLLECRAINGNLPESRGVLSRFLKVDMSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFP7</accession>
    <name>A0A9D4QFP7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cement protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050589"/>
    <dbReference type="OrthoDB" id="6514136at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039271690" description="Cement protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="9371" checksum="3CC793909BF1EB40" modified="2023-05-03" version="1">MRILLVSLLICALAGACIAGLVGYGGGGGGGGGGYGGGGYGGGHGYGKSLPGPSFLIKTLHHVSKVSHGGPILSNYDLGVSYGHGGGGYGGGYGHGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGA1</accession>
    <name>A0A9D4QGA1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGA1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058053"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="116"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="278" mass="29707" checksum="4D70492F21CE62F1" modified="2023-05-03" version="1">MDGGKVGGESTCAQSCGNSDGQRDANSLPEDGAASSSHGVAAIDSDAQRPKLATEDGPGTSRAPEQTAPKRPRSPDTYGCSSLKKVRLEEYVPASQVIDHELRDRCEVKLSCFAVRTTFRQVADICKGALQVRVGHHGRMLAWAYARYASEEEAAAAAQALQGTVLEGARIKVSYCGEKWKDPARRPRYLPDTLDVQRLPSNSMTMAKVAAIFPTGRVLMVTNTGHAKVKFGSTEELIAAVRKPQCHVVGGKKLKFAIAITSRPAGHEKEDDGGSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGZ5</accession>
    <name>A0A9D4QGZ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_001441</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGZ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047835"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047859"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="18">
        <location>
            <begin position="157"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7981880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110414" checksum="0CD5A1E499DF09D2" modified="2023-05-03" version="1">MIYFTSNLECVYGGDYDGYATAIRNYFAVFKACNIELILVFDGGHDVSNRKLKTTQRRLQERLATAKAIAKTGAPNLKILPILAHEVFKDVVRELGIQVFQCSFEADEEIAAIANHYGCPVASQDSDFYIFNLVGGFIRLDSICTSPQIVTAENGENFKPIFLGTVDPNSEAGRYKRVVDTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDFFKKEICAWAWELLTEVFKLQPDRLYVTYFGGNEAAGLKPDLECKEIWKKLGVPEDRILPGSMKDNFWEMGETGPCGPCSEIHYDRIGGRNVAHLVNADVPDVLEIWNLVFIQYNRETDGTLRLLPKQHVDTGMGFERLVSVIQDKPSNYDTDIFVPIFEAIQKATGVRPYSGKVGKDDVDGIDMAYRVLADHSRTLTIALSDGGRPDNIGRGYVLRRILRRAVRYATEKMNAAPGTFARLVPVVVEILGDAFPELKKDPEGLASQGGDNKVDAGLKLDVHAISELQAKGVPSTDDLPKYDYSAKSEDKNAAYEFAPCYGTVLVLRTSKTFVDSVEAGHQCGVILDRTNFYAESGGQSCDTGFMTSEENEDVEFAVNEVHVQGGYVIHIGRLGSGTLKVGDKLKLSIDEERRKLLMNNHTGTHVLNFALRQVLTAEADQRGSLVAPDRLRFDFANKVILHLYEQWCPKLELCGMFPAPKIAFSACSQLNVGLKIWYNGASFFFQTYPDPVRVVSIGIPVEELLADPSSPAGSVTSVEFCGGTHLKRAGHVGDFVISTEEAIAKGIRRIVALTGPEATKAVKKAEHYQSEVNRLRTEVDKVTQAAQGKELVKQIVELTEEISQSSISYWKKDELRTDLKNLKKKLDDLDRSNKAQAQQLAIETVKKLLEDKKDCDYIVHTLEVGDNAKALDAALKQVRTLTPNAAAMFLSQDNEKGKVICLSTVPKGIVARGLTANAWVKEVSEVIGGKGGGREESAQAIGNNVGSIEKALQVANEFAKLKLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH52</accession>
    <name>A0A9D4QH52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_004417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035370"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041317"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7982408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="529" mass="60391" checksum="97F65E21B64E5475" modified="2023-05-03" version="1">MTPPVPARKCLTLEQKVQLIREVEKGGRQKSEIARQFGIPPPTLSTVLKNKDAVLDGFEKSFSAKRKRNQDTNDDCEDCDDLYEAVNSIVGGDLEGNFESFAMADADVPIVAPATDAEIVDLLGGPDEEEKPLDEQPREIPTVAQTQEILLLLRNRVECAGGDHDLIICLNKLERALLAPSRSTRQSQLTDFFVREQSLLLSLALGVRQRLWPTSESPLQGVLQQLSRLGLIMAYFFVCDRTNFFMRENKYYTHLNFFLPVAYVFALGLFFTEETQQTQVLHRDQTDEWKGWMQLVLLVYHMTGASQVLPVYVHVRALVSAYLFLAGYGHFSYFWHQADFGLLRLARVLFRTNLLVVLLCLCMNRPYQFYYFVPLVSFWFLVVAATLGSLPRISAASAEANPLHHLYVVLKFVGLFSVLTVLYMSEAPHVFMTDNSRPEKDALRSIWTSAQQLLCHFHVLQAEWRWLTSAKSNVLKDDRRRFMAAFQKEREAMEEEFQNELQRITSLRTSSPSGDKLLAAAISQLKKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH78</accession>
    <name>A0A9D4QH78_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH78"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10383" checksum="799BD7077D35D928" modified="2023-05-03" version="1">MDTGMDLDAPGDLNFDPLDPSLPAPAQQDSSGQLAACPVQMGLSERESFRHRLIGKERLLRTSVLQTCFKKPLSHQFCADVEAHRISDLTMQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMS2</accession>
    <name>A0A9D4SMS2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030808"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9237" checksum="719B4C84A4006AD0" modified="2023-05-03" version="1">MVKASWAEVTATCVQNCFRKADFADVGADADPEASEEDHSGGDLWQCVVDSDMGGRDICSDDFVMADDDADTAEPCTDEGIVNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNY7</accession>
    <name>A0A9D4SNY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_008446</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNY7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="12">
        <location>
            <begin position="328"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="504"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7935479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="785" mass="88070" checksum="FEC692B223ED80C6" modified="2023-05-03" version="1">MADHWDAPKAPRGRLSQTSPWAGVFARGMRRSGVVMSRCLRVYREIYCIRPSNYFRMGREPTGQSRCPRSVSLPGVTWGMSIACPCNRHPSPAVIQRWHWAPYRREGYKMVRCCTGRQPTRVCVCLAGRFQDPDRASGVPSYLHRGFCPPMQSRSSFWNWTRAGDTAVQRCPGGAIGHARWRCLPGSPPYWEHDTPNLSACYSAWMENLKSRADDDDSVVSLAVELEVITRTKTLLGGDIAQTAGVIQRLLARMTRRLDDFSDERRRFQVVKELLQSTVEISSNLLEDYQRDSWLELPPRERRHVAGALLQALDNSTWLLADTKNAAFRFSRAHGNVLVSVRLVETWAASEIRFPVHEDVHGTVWMRMQDTLVFPPQALLGSARNGVVKLVFMAYRNIEDFLGPDVASAERVINSRVIAASVNSRHLMKLHQPVLITFQHREVENVTNPRCVFWSFDDEEWLTEGCWLKETNETHSVCACNHLTNFALAMDRRPPELTSTEQKLQLFVYASFATCMVLLIAAAFTLQAFRSLKGERVTIHKNACVCLLLTEALLASGVGGHPQRVVCGVLAGFLHYFWLAAFFWALLEGFQLYTVLLDVLGTDPPSSRLRWYYLLAYGAPAVIVCVSAGISPSSYGALPSLGTSLRKACWIDMEGHQLWSFVGPAAFCAVLCLIFLAMVFCKARRHVDLHATLKSKEQERIASTRSLSSHSLLVLVCLCLASSFAQLHVSRGSLVHTSLFSVLNILLGLAVLVFYCLSNDKPMVKNLTFLIFGASVWDISVNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP80</accession>
    <name>A0A9D4SP80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP80"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="455" mass="50900" checksum="C2E83C368498ACDB" modified="2023-05-03" version="1">MEKQPSKSPNVRDSRVPDEESSEDHFSVYDDVAIAIAIVVAAGVLLGSLMLRSKSRSLAQQLFLQTGTSSFCCPDKVRELVRYVNSTLEPCENFFDYVCSNNVYSRFETDTTVDSSLERFVATGVPPENHGRGGEVAVFMIGYFRSCVASLGRRDSFASQMTQSILRVAQDVLRHPNGRNSFQFMVEMSVRYMIPSVLEITYNPWDTTLRIQVRAQCEVSLMSADCLSASVKAVRSAMNPSVNISNTEKFMAELCRRFPAALQNSTYVWFNATDAISTQLWDARDVKAAMSVVGYGATNTTVIEAFGLLQIRAIHDAFAMQGNCWSQGSVPLVAQCLRGRFGLPAYYYAVVHGRVRSLHEQGPVRRRRPMAAAERRGDNAAPSGRPGDRHVRRRQASRAARRRVELAVRRRRRRGALAKPDRRSRRRDSNNGRTHAASPQKSHARSTLSPRTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPQ2</accession>
    <name>A0A9D4SPQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040134"/>
    <dbReference type="OMA" id="WDECVEV"/>
    <dbReference type="OrthoDB" id="6480354at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="25564" checksum="609DF270FCEC672A" modified="2023-05-03" version="1">MNLVEFEDVLQGELGRYVKIVGCVVGFDELQFMAIVEDSRRNRLPVRLPAIETSVNINRFQMFMFNGITARRYENEDERCLQVLNFMHVDHGLDMKEFDNVQRLRREVLAECVAVNSKVANKVFADLCDKVDFMVEDWDECVEVVVKHTDRDEPLPVNEDHVSLEEFVYEKCDEPRLKCLRPLPFKYEDLVKQVFKAVGEYRYTSLSFKRLLERLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQF4</accession>
    <name>A0A9D4SQF4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048225"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="18171" checksum="C3428C869FB8707F" modified="2023-05-03" version="1">MLTGAWWNVKTSTISNCWRKAGLRKAPEQLEDDLEENHSTPGDLWTEVEELLPDVSSFNDYMESDCAALTSADLTTEEIVNSVRDISSDDDDPKDEESMTPNTEADESVTHSDVLVHMDKVRTYIGRCSDVPDEVLRQVEGDLVNKENTSKLPLQALLQNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQM5</accession>
    <name>A0A9D4SQM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_011382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056639"/>
    <dbReference type="OrthoDB" id="6508424at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7939352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13541" checksum="2A48AF63EC19C927" modified="2023-05-03" version="1">MEDIVLEYAVFGTLMALNFGLGLYFSLRRKARLAKTTAEVFLGSRALRALPLAASAVATILSSAGLVGFAGHFYAYGFHLIWHSLAAVATAPVAVYIFLPVMYGLRITSVFEVFFWLLCFVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQU6</accession>
    <name>A0A9D4SQU6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQU6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038963"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="466" mass="51590" checksum="6A72CAC64797C1B3" modified="2023-05-03" version="1">MYICTFIVEAEPGTKVLNEIREGKLTSKVASQLALVAATHNFDGWLINIESKMDDSCGLFLKEFLEAVTSETHRAVPGSLVIWYDSVLLDGKLDWQNELNDKNSCFFDLCDGIFLNYGWTEEMLQRSASLAGSRKSDVYVGIDVFARNTKYTGGYETYKAVKQARRNGLSSAIFAAGWVYETQGREKFVENQYLFWNFPRHCRSEWRLSTLPLCTSFCQGFGRNLYKAGKLVQRGPWFNLSEQQLQPWDQGCSLCGGCGAAVVCTDQAYNGGSCLLLRFVPSAIKPDASPYFRLFACDLPLGSLSVSYTFSPDVDRTTGVDIVLVLKVQTSSGEEEQLMLGVTISTPDDKRYEAKLVISDVPAPESSVGTECAWQTRKYLVKDLQTDHIATLREVGVSFSFHEPTVAGSCLLGELALKRPDGTSENVTAKKSSSNEGLEDSVLDDGARSDGAEPHVKRQRVQDGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQX3</accession>
    <name>A0A9D4SQX3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_006733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQX3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052861"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="91"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7943299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="523" mass="56849" checksum="95C54FA7E63B7029" modified="2023-05-03" version="1">MDVCGIIGDYGKFQKNIFWFGLVRGTFMGLHLVVSSFFAPEVDHWCAADPASHVTGNATTLDSGRLGNLSRESRYLAEESDLGLGACSRRLTTTVAVGDNRSLVPEVLTTSSSCETWNYGNSFSGHTLVQEWDLVCEHAWLRPLVQSSVMTGMLLGCLLCSALGDRLGRRPVLVSSCALTNMAGLATAAAPSFGVFLAARVVLGISLAVMQTASFCLLVEVTGPKQRTRAAVAFSLGFALSLFVLPATVWLIQHWRHVQVAITVPFIAMLVWSWYLPESPRWLVAIGRTKEAASVVLRAASSNGIEIQDMDWENEEAEKVRYLDLVRQPRIRRYSVILVYSCVSCGAVYYGIQLSMTSLGGDPYVGFLLSGLGELAAVVLCYGTVRWFRRRTAVPAMYAGVVLCSLGLGLIPQSLTWLRQVDGLVGKILSGSAFTVTWLYAAEVFPTVLRTVGVGACLMGIRVGSAFVPLLLETRRYTHESVPMAVLAAMYALAAVLVLLLPETFQVALPDTVRETLDLKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQZ0</accession>
    <name>A0A9D4SQZ0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQZ0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15329" checksum="194D4CE6FD5BBE72" modified="2023-05-03" version="1">MTKHGAMQKLRSARTKLWLAPEFLTNEVLEDTYSEFPESNSTSFTKLWVQTRRFGRHLLGTKAGFLAHSLMESTALPYVQYVHLLNEVRLSVGALVPPLYYPEGTTSMLYGGLGFFYAKSLIDALDSEATRAVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR23</accession>
    <name>A0A9D4SR23_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_022065</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR23"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044016"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="16">
        <location>
            <begin position="142"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="17">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="539"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="894"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7940150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="944" mass="104066" checksum="9278B6E66A7E6A00" modified="2023-05-03" version="1">MAANMYRVGDYVFFETSSTAPFQIRRIEELVKTANGNVEAKVMCYYRRRDLSLEKPLVGALEEEQEREAEQLTEKERHQLRHRELFLSRQVETLPATHIRGKCSVTLLNETESLLSYLNKEDAFFYSLVYDPQQKSLLADRGEIRVGQRYQAEVPPWTGPPAESGEGADDRDSALLETLVYIPSHGLSDRQLDQFLIVCRSVGTFARALDCSSSVKQPSLHMSAAAASRDVTLLHAMELLHRTGYDLARAVAALVPPGGPVLCRDEMEEWSASEANLFEEALEKYGKDFADIRQDFLPWKSLKNIVEYYYMWKTTDRYVQQKRVKAVEAESKLKQVYIPNYNNKATGVLGGPEGATAGGRPCESCYTMNSAQWYAWGPAHMQCRLCQSCWTYWKKFGGLKYPTRLESADVLGSERLPAGMASHRPHRCTVTGCGKEFKLKAHLARHCATAHGLALRAGSPRPVVKTRAAFYLCTTALTRMARRLAGPAALRPRHAARNPFLPVNSAAIRLEVQGKLDPAVLAATPSAAAAAAAALAAARRRPRERGAVVDVSHRLGTPNLPRPEWLHPTPREQIPTPTRHAFPPPAERPPPLLLHHQPPQQQRKRTAPEPLNGPPGGPRRRLGPPPPAVPLNGGRPKVATITRLGGGRKHLISWVDAPDDLYFVATEATRGKVRAKDAASSQTAVHEASPSHATDAGGSSAPAVQCSTHAGDARLDSALVTEEEVRGAHAREQEVLQQLGSTPATARKIENFSRRSGAETVATEPAAPYTIVELDAKEDCTNHVQKRMGTALRNLVQKQKTEGRSLGGKGRLTADLITRLSTYYGRALKSHQGDVDEMQRAVMATYHHVTSTDESPNHSLCPTGEQSWCRHNAAKAKGNKHSEASILQELGMNATNTGKMRTAEKDKRRSAMSTKRHAASEGLKKRVAKKHKDSMHPDYAPGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR73</accession>
    <name>A0A9D4SR73_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Protein deacetylase HDAC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="33">Tubulin-lysine deacetylase HDAC6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">HPB52_001584</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">Rsan-2018</strain>
            <tissue evidence="36">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate</text>
            <dbReference type="Rhea" id="RHEA:21548"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:21549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
            <location evidence="5">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR73"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035930"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032886">
        <property type="term" value="P:regulation of microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10002">
        <property type="entry name" value="HDAC10_HDAC6-dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0678">Repressor</keyword>
    <keyword evidence="24" id="KW-0804">Transcription</keyword>
    <keyword evidence="23" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="17 34" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="35">
        <location>
            <begin position="834"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00050910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00068733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00082852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KAH7942802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="938" mass="104159" checksum="65228B2B3E444DD8" modified="2023-05-03" version="1">MPLGDGTGLVYDERMAEHLSLWDSRHPECPERLTASYQRCVDYGLVERCVRIPARKAEEAEILASHESEHLEQLKKTHGETDAEALEALCARFDSIYINSKTYELALLAAGCTKDLVTAVVQGKASVRNGMALVRPPGHHAMRNEYCGYCFFNNVALAAKYAVDELRLKRVLIVDWDVHHGQATQYAFYDDPRVLYFSVHRYEHGEFWPELRESDFPYVGRGAGAGYNINVPLNQVGLGDADYLAIWHQLLLPVAYEFQPELVLVSAGYDAALGCPEGLMRLSPAAYAHLLHPLMALAGGRVCVVLEGGYCVSSLAEGVALTLRTLLGDPCPGLPQPLGRVSDSVTETLLNCVSVLRSHWKSLQIQGTSGTRKAVAGSTEYLPRSEYRGQLGVQRPEKFPTRSGYYEHPPEDKERLEEEVAALRSKTNLDVPPNRTALVYDEHMAKHRCLDEKGHPERPERILKPWHVMEKRGLLNLCVLLDSRSATVDELLMVHDKKYVQKMRGCQEMKNADLIKLQEKYPSVYLCRDTFSSALLAAGSLLQLVDAVCKNKCQNGMALIRPPGHHAERDEAGGFCIFNNVAVAARHAIETHGLQRILILDWDVHHGNGTQHAFYDDPRVLYLSIHRYDNGSFFPCLPEADFGAVGNGAGRGFNINIAWNSEGMSDGDYLTAFFQLVLPVAYAYDPELVLVSSGFDSCVGDPLGYCRVTAEAYAQLTHLLLPLARGRVILALEGGYNLSKLPSAVCHCVSALLGLRPPQLRPAAPCPRQAVPCAVQSIRRTLGAHRSYWPCYDLPSEEWLASNGLVPDGALSLDLAALSLEDEEGAPFCIQPETWCPHLEALPPLPEAGLSDPRSPCLTCGVRREVWTCLHCFKVYCSRYVNGHMVTHHDETQHPLVLSYSDLSVWCYDCNFYVTNPVLQAAKEDAYLKKFGSVEFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRW6</accession>
    <name>A0A9D4SRW6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_019438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRW6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027699"/>
    <dbReference type="OMA" id="TEWDYIA"/>
    <dbReference type="OrthoDB" id="10012364at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17099">
        <property type="entry name" value="FERM_F1_PTPN14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF1">
        <property type="entry name" value="PEZ, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="845"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="750"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7944424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125286" checksum="FEA6C8279E3E4976" modified="2023-05-03" version="1">MPFRLKLKKSKHYSVVSKSLCVIAVKLLENATVECIVSSRTAGRECLQNVCQRLQITQPEYFGLRYQTRDGQLRWVDLERPLKKQLDKHGAASSREGGGCCSLQLGVMFYVPNAAQARRLLQSDVTRYYYFSQLKSDVNEGKLPCERREAIRLASYSLQAEFGDHRPEHHTAEYLRNFVLFPKSVLLACANEEEEAALLDEIVNAHRSLQGLDHATAELYYIQTVQCLEGYGEERFEVRDPSSGVDMVLGVSVQGVTARRVRRSGDQDTSQAAVHPSPGEEQQHQPALYEWSEIVDLIHHKRNFKIVGRDAAHSAQFQLEDVSTAKYIWKMCVQQHGFYMSMQESAAVAPGGVMGETYTRAPSINIGGGESFRWTSVPDAENTGGERGTDVGESRESLDELAVYHTETRNSENYAFPGSTGELVDPNHNGYNHHPTNPTPVRENVAASTEHIPMHNEIGQQANSVHHSYVSLPRSSESATDLRRALLPSYRQAPDYETAVLNKYGVTSCSLNDLPLETRQNSQVYHQQQHPATTSAVSNELDISLSRSCNPLLPPLSYMHYGNFADLTELGDSMSFGDLANNNNNRIDGIAHGRAPPLLAPPLHTYSTPELTSQGLSYEVNPAQLFANMHLNYQYKPPPPYPYGQRPSASTPDLTRNHHQLRASASPDLVSRRHLSQSTIQGSEPSLPHYQAAVNGNVTSESLRSIVEPPRPVLPTYVPVGESWNAQVSGVAQPQRIQVCVSSPTTREQVAAAAAKPVDATPVPPPRKQVTEEKREPPSQEASPAHPLGPMMVAAMNGLTLTVAQPDQLLTGDQDSADQESPSPSTSKDMRPEQILESRLEDGQVFLEFERIAKRKPNADFTTALLSENTSRNRFSDVLPYEENRVRLTPTPDNRTGYINASHVSASVGDSQRFYIAAQGPTRETAKSFWQMVWENHVGVVVMLTETEDEHGREKCFQYWPMADGDDAALSFGEYRVARKGVVSSAVAVTTSLTLSRSQGVACSHRNVWHLRYTDWPDHGTPGDIQGFLGFMEEVDSVRRLASGDQRLLRTRNTPMVVHCTAGVGRSGVVILCDILLFCLDHNVPVDVPRVLSSVRMQRMLSVQTLAQYKFVYHVLIRYLRNSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRZ9</accession>
    <name>A0A9D4SRZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036849"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057049"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1594" mass="170436" checksum="11232EDE846BFAE3" modified="2023-05-03" version="1">MNRDLLQICSFCVYGPRAVKQNKCHSVGSPTPSSSSSPPRTPPGTRPLDGLVLLTWAFGVQCLYMAHLPSHMERGRRSPDPAACALLASGQTPAAFADIVAHSFFPALDMAPPPFTAQNCLPAYAEDIPGPVRVQLFKYHKNPDDWAYPLGLMVLAKAGLLWQEETFFEANVLLVAPQQRQAYLATTETLAWFTIGEALAANLPYVPPDEAMALHIVIVVVMAGIVLEGQRRRVCLLWRPFPNPPWWVYGLPVVLLSSAAGAAVMGLSAGYKRHLVQAIKAGAHEYEEIVCQSVLSANRVACSDVWELLPPQHSAGSMLSRHHPTKAQVQAAIKIACLFPYTASTESIQRAALAVQITAATAGRHDPFLPPLAAPARRSTRDGHRRSASTSLINFVSPSLLTAAAIRAHDLNQKCADDRTRQWLALKAPIPGWPQQPHYAPVVDTAGQPTQAENIVAAAPVSTAQAGIPKEPVNFPLPPGSDEEGVMDLSHTRKRNHDDDSSDEEQMAPKKLPVPLSSPENHDEDKAKSSDLSAQSGGSTACPPTARSLDGASSATTASTSEAHDGGAATAEDSSSDTTALLAKSTLTATQDLTASDGDDMEEDHEAEDCAARRKGTKAAPTAADFLRTAKTRAPARKAKKRSKKGKKATRQQQAPATQAKAAYSSQDTTPAAPPPPAEEDFKEVCSKAASCRARKLESAALPVDSAVVGTVLFKPSAPGGSFKGSPRLTLAQVLSSRPGVAAIRVNHQRNIVAADVTTRECLEQLLALTELRGIAVKAKQPADRLTSIGYLHGVDGEPDNASLLSGLQSTLPVLSATREGSTVTLRFAGPVPPQHVKLFLQDPALCSADSVGASATPERPAAGPTVASDADVPTRKGRHASAQDALTVAAPMLLNTRLSSVGAGAQSRDHLGHFHDSPFKESGPSGGTGGGARNPNPQAGDLLLPVALDWTPNARNLLQVLLEEPLRILLLSMVRQPLPRSRLQAPPAVTPTVPGPAATTPAQNPLDSLAEILLQAMSRPAWTAIDVSLATPGASYGWATEPGSWGSDHLPIVITPAGGKVPRTRRYAVVDWRLYRHHLDTAPEHLGIFEAMAGAAEAATTVTSAPANQPAADLHHLNLKAARRRAERAFLRGGCRTLFNRLNAACRRHANQRWRQGWVGICQTVSRNKGGSRAWRLLRSLLVGPSTLQPVLSLAIALNIREDTLAEQFADRFAAAVAVQPATVINQGAPCLPQGHHPAWAADQRGPLPGTDHGTRAQRCPYWGYGLSVVLLSSVAAAAVMALSAGYKRHLVQAIKAGAHGYEETTAPLPSLSNCLLYFAERPAWAEALLGLSVLKGFIYNRDASYVLEHINAVPEADRPVFTESANFLIFRTVGDLALASLPDVPPDEQMVAHVLLVVFIAVIVPDGQRSSVSLLQQVLPNLPKTSPAPSVSNCLSYYQNTDDWAYPLTLMAFAKAGLLWQAETFFQANVLLVAPQTRQEYLATAQTLLWFTIGEALAVMLPYVPPDEAMAFHIVIVVVMAGIVLEGQRRRVCLLWRPFPNPPWWVYGLPLVLFSSAAGAAVMGLAAGYKRHLLQEIKAGAHEYEEIVCQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STN1</accession>
    <name>A0A9D4STN1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047776"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36648" checksum="EB1F3E9DC915224A" modified="2023-05-03" version="1">MKPDGKDESVIANKRFTALCLSWNVILSILIVILNKWVYVYVNFPNITMTMYHFAMTFAGLLVCRAFNVFQVKKLPLRQMLPLATTFCGFVVLTNLSLGHNTVGTYQIIKTLTMPTIMVIQHYWYKKSFSLGIKLTLIGFFSAFVLCVYAGFQVQFNLNNDEHGYNYMIITNCIARLVQWVGEKQKEFQVNSMQLLFYQAPLSALMLVVLVPIVEPPWAPGGFLYQQWSWLHLTLVLTTGVVAFLVNLSIYWIIGNTSAVTYNVVGHMKLMLVLVGGFVVFQDPIHTEQAIGIAVTLTGVLLYTYIKVQQNVKERLVGAKATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUC9</accession>
    <name>A0A9D4SUC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028601"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7947522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="430" mass="47956" checksum="C773296D6643AC4F" modified="2023-05-03" version="1">MNQTRRQQMSRTDFDECVKPRRPLQGHRTSTPFDYTTLEADGAMIRMTREHRLTGFGEFYELRSFVFLEPMPASQVCNVCGTVSSLAVNLPCGHVFCNLCKKMIIRKQGCPIDGIKCDPDDVYGTHLSRDDLEQRHVLCGFGGATCEFSGTLPNVMQHMQNCNDDKYKCPNCDGSVFRRQAYIHCGQCNGGYSEAGSVVPSTVLKDPRVVDDDAEALRRCESSESMTKSIGVQVGNSIMEHVAKHEGEALPMTNVTESQDHSCALQGSSKAPITTGPYRAASKPGVSIAMCVFQGVPVEVSSFKDDEMDLNIASDQCTLAGYTFRVRCHFLGNERLGARIHFVFFLESGEWDDSVVWPFAMKVTLVLSHPMDAEMDIRLPLTVAESADTARKPHHVVPSNGYKTRDMHWDCILQNGYVCKKKLYVNVEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV09</accession>
    <name>A0A9D4SV09_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_020227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV09"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037249"/>
    <dbReference type="OMA" id="GMPWERY"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="313"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7948283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="719" mass="80121" checksum="3F5487C4C42AB624" modified="2023-05-03" version="1">MASAAKPAAPGRRAKVGVKTPRGDLLLDLDLDLPLSTIVEDVCHDVGIADPDLYAIKYDGSEVYVFDTNRQDIRNGDMLQLVRMPMNKNEVVEKLSSGTPDEKAEALQALLILAADPDSAVMFIARDGHRSIVNWIEVGVYKGNLLCRAIQCLQGLIDQSLITWEILSNKCLSRILKETNCANGTDWNNVEVFLSALECVVTSNPSAYETVFMGMPWERYALLMQEGSVVVMRNCVMLLNALFAQGNPGNRDALKNAISNWKIKSVVWTRLKNYGQVDAELAHALHVFQAQMLGLYERLRNASVDTEDLALNGKVDILLKLAQSGLKSDDARYKQLDCKRRLSIHHTAMGLEDVSVPLNDFAKPAGRLAIENLLYFADKYNLSFTTAIQENLFSSSEHMCPLVESSILLTELLCRVFRVGQPAGDDGTFMLMYFSHECFFEEVFSVCMLLVFKTWREMKASKASIRKVFGIVNEQIVRALRLNPHCLDINGFRTTLSSLPYSEILKQLQRENDERKASERQSRAVNQLRDSFRAEIVSLVNENRINVLCNGARFQKFGAKGNRIKDGYVFVKLSRNLKAIHYGDCNATCEDVDIEELCESILVSDIEAINTGASCPHARKAARQIVDLAFSVVVCGDGQPLNLVAPNAKVFNRWLDGLDVLLGNTASSIEARGDMGILLDMEVRLRLLETEGIHIPETPPPVPPPPSNFDFSSRFFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX00</accession>
    <name>A0A9D4SX00_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX00"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="458" mass="50113" checksum="4D1F3E1A3849517C" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAECQTGDAGTDFLLVDMKVLNNFFAQAKCDKCDAKSLSVRKATDKEYGLAPQDEGYTDWLATHEFQRNIECNSGRTEVEAALTMFQRSWAKHGLRYMTVLSDGDSRTFHALSEAEVYGFIQIDKKDCINHVHKRMGAALRNLVDKKKAQGESLGGRGKLTQEKIKKIANYYGYTLRSNINDVPAMKRAPVSARLSDESLLARCCEGKTQNTSSASGKRTVSRIAAGGVPIVPASRSYPCSVLLLLPLAKVRRRNRMYSSRYRIFELLLIGSIRDSNCNGCKSALSAAMIVEGNVRGWQFVIVSLRGGFVRFEGADEDEGAIGAIAVNGESARRKAQHKTARNSVDAEGRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXH6</accession>
    <name>A0A9D4SXH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044824"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12534">
        <property type="entry name" value="RRM_SARFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000022">
        <property type="entry name" value="Cabeza, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034870">
        <property type="entry name" value="TET_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23238">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="254"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7955790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="457" mass="44003" checksum="C04031460D0E70D4" modified="2023-05-03" version="1">MWGAASNVASTPAATTYGQDQYGQQSQSYSSYQQPNSYSQGQSATYGGYGAQPAQAPPPAAASNTAAYPPAASTGYGAQAQPAPAAGYGAQQPAPQGAYGAAAGYGAPQPTPQQPQQPQQPGSHQYGAAASATPYGSGYGAAAGAAPYGQAQGPPGQVGGPPQPGGAYGGPGGPPQPPQPGAPAGPPSSYGGGDYGRGGGGPPGGMAGPHGGPPGPPSGGGAGGGGYGGPPPGGYGGPGGGFGGGQGPSEEMADTIFVSNLPEDVGEIQLAEHFGAIGLIKIDKKTGKNKIWIYKDKITGKGKGEATITYDDPPTANSAITWFHGKEFMGGKINVELAQRKTPFGGFGGGMGGRGGPRGGRGGPRGGGGPGGGRGGGPDGGMGGRDGDWKCPNPACGNNNFSWRVQCNRCSAPRDGGPGGPGGPDNGPPGMRGGMRGGPRGGRGGPGRGGPMRGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY39</accession>
    <name>A0A9D4SY39_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY39"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047648"/>
    <dbReference type="OMA" id="AVWFAFC"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="44"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7956480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="343" mass="37905" checksum="95A629E88C00293D" modified="2023-05-03" version="1">MADVFAVGLHTFGDGGYAPHLHKVNGTWVSGTGYEIGTGSTGLLSLLSVIGTSLSIVGVVLTFITYSLFSDLRTLSGTSLLNLLAAFFLSHLLSVIGVERPSDKRLCVTLGFLLHFLWLAVHCWLAAMSRDMYKTFRDNINLQPSPASEDRKSFLKAAAFAWGLPLLLTGLSGVVHFGTVLDQTSDDRITCWILGRGSYLWTFCLPAFVLAVSDVRYFVKAAILTRYTASLQMNRKTRDRMKRRRYLQLFLYAKLLLVLTLTWVAGLAAQLARLKAVWFAFCILASVQGFFVALAYSCNSRVFRLYSRSLRSGNHNRKGYGASDLSGSTDLALLTWEPTPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYM4</accession>
    <name>A0A9D4SYM4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYM4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15598" checksum="31BF888B986BFB96" modified="2023-05-03" version="1">MAPSSGHRSATLRLSVIKSERDANSTPRSVVHDVSYTGRLHRNTVPKRPRAVRRKDENLRAAPIHAPSDDCVSDVDLWPRVDISDIHEFLVLRTSFITGEQLNSRKALEGHSYEWLGAVGEGSRRRHRDRRHPSKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYR3</accession>
    <name>A0A9D4SYR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054774"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74163" checksum="8C3B03EFAC0D605D" modified="2023-05-03" version="1">MASTSAAATVPVPPRQASDFVGLFPLDLWRRIFTYLDATSLLAVAEASPKLKRFAFCSKILESLTFDPETDERIVKKFVLATREQLVDGDRVQDVPLAPHVLRLRLNNCLAFPSASILDIARYCHNLQELSCVNCVVEPIALFDLLALKLTGVTKLEWSLYEDSHYKTWLDKRTVTHLRTFPRLQGPRLNTMYVELAVTDETVYFLDNFVAQCRQLRHLHVHAVRKEDPDVPGSEACRRELTKRKRHFETFKYSHEELLRPMNLGTRMIEREMRRRTYSAEDAVWGNVDCRFKPEEATNLFTFADVIERKVILRGIKQAVVVVEGDARSTCLFEHAAGQADLWKDVSRLSLALMPPRGFEVPASPTAHRGYMNPMMQFFDACVSRLVELNMTAFHFTEEADCCLVVASTLPNLRSLALAPCGVNHAHSLESLACGCLFLEHLDVGSDGALSCEACHRPLLFTARRIWTLHETTRLRRLSIGETATVADLTFLQLCRVVELRLNVDCEDAAKVRDCTCTLGELLRSNPLLTSLTLVAGRETLGARFAENLSAVRSLQHLCVLTTTKTAEREAEDFFMILEDCLPQLRSLHAHYLDVRGTVQVRTWLRQWRPDYTPPTIAKWRSSEGVFLHDRPCLGRLCSVSTFIGLVRPRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYS0</accession>
    <name>A0A9D4SYS0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYS0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25045" checksum="F5E033732FF9ABAE" modified="2023-05-03" version="1">METRKKALKAQEASKDTSKAEWVMCSVCDSWAKLQDTAFSSIEEADAAPDYKCRQCTKLNSFREEMMALVKQVSECNKLAIADLRMRLEEETATRRREGEHLEALLRVEKTRNAELATKVALLEQPNPSLTPISMMASKGTEMTAQKTPLSTGSEQANVTGGEANAGAGQAVLIWTVSALPICFADIQLSEEYRLFKPLRRLPEILAARKNAEFPLLPVWNEPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T081</accession>
    <name>A0A9D4T081_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_012481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T081"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052214"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038832788" evidence="12">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7961831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="181" mass="19614" checksum="5BB77436235B4777" modified="2023-05-03" version="1">MIAKILFVTLLASTCAAYQRKLEVQDSDGHDIQFPHLLYTSNSSQIQLSLLNLSPQLGKTSQFGFELTILDDSSRNNTYGISSARTFDDEYTPGVFTHGSHTEHLTVASSAITVAFGSEGDGWYQENNYATWAMSSGFGERPLEHVSATVLSVTSVGLGIPAIIALGTVIYVSVHKPEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1B8</accession>
    <name>A0A9D4T1B8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_003726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1B8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.70">
        <property type="entry name" value="Designed single chain three-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7967875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="517" mass="56519" checksum="C67B50ACAC68989C" modified="2023-05-03" version="1">MAMQVTGQGEDISPEEFQCAGWTTALSKRKSTKESPPAAGVPVTGPPYGKNVGFQSPANVKKRLADASRLPRLPREHFRVIVRPRGGLNVKNTSNLRIAQALTTAAGLSAADTTEDIICPNAMQNIVVISTPSPANARAYASLEAITVGQTGYDVSSYIAAPDNTCKGIIRNIDMEFDHEELRRLIIQPRNPNVLEVRRIKNSTTVVILFEGLKVPNYIMCGPSMIRCTLYRRQTDVCYACGRPGHRADVCPTPENAICRGCGISSPGDQHVCSPKCAFCGGPHPTADRSCRQRFEVPYIVRQRRRERRDFEKNFPPKGGPSEPADKPRSRSTSEAPMEKPAATETEWADRVKGSSKKVTGGTPPEQNNDRIIQLERENAALKAAIEQLRAEMAELRKANNAKSDVPQPPQVTSVETPMEVPMEAPCPVRPAKKRALTRLAHDEGLDSFTTEIRDMFKSLRDTVAMVNVKVDSLADKFNALDAKVTALDVNFCTLDAKINALETKCGSFEPSHGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1R1</accession>
    <name>A0A9D4T1R1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1R1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034501"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="19696" checksum="54F2B909E593FFE6" modified="2023-05-03" version="1">MLIAVGRPAANLPLRVSLYSALEMVKASWAEVTATCVQNCFRKASFADVDADPEASEEDHSGGDLWQRVVDSDMGGRDICWDDFVMADDDADTVEPCTDEGIVNEVRGKSDSEESDDDDDETLEPAPTSVPVAIGYIDSLRQLVYAKGLGEEHAAALNKLETTLIASALSKQTCITDFFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2B3</accession>
    <name>A0A9D4T2B3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2B3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035065"/>
    <dbReference type="OMA" id="YEFISCC"/>
    <dbReference type="OrthoDB" id="6480050at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="83"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="32164" checksum="BB6DC6EAB1E6EC2D" modified="2023-05-03" version="1">MNNEVVDEIEETHELVKESLEKLKQLIAGEESLSCPEEDDFLLKFLRVRKYDAEAAFQNIRKYFKVREEVGDIFDNFCPSGILYDTICRQHKLVMVSRERDPFGRAVIVMRTGPWNPSVCTLNQFIKACLVVLEWVLLDEDVQKRGVVYVLDYKGLGLEHLLHLTPSVMRRVVHISEKCFPMRVKAIYVINDSPVFDILFAITKPFMNRTLVERIHMIGYELPKLHGIVPADCIPEEAGGTFESYDYNELEKDLRSQRQYFEYLSLHGYGKENTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Y0</accession>
    <name>A0A9D4T4Y0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Y0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056000"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="927" mass="102775" checksum="23A20A0F86E4D606" modified="2023-05-03" version="1">MPDGAGHSSYRGSYKASRSSDSLRAAQEVSKLPRLSRRQSSTVPIPITPNEATDLSSASRRRGAVRRQQRTSEVVPLYSAGDRKPLSAPFVAVTATDATARVPQQPDESTRSNATERATYSLTPSQASFTSRTVKEEPAPLTSDLDKVMDAPVMPRERTSDNRSAVAVTSDAAPFTSKEPASAARTQRKQAAAPPRRSALTRGTLRLTSGRGKLGTGRGVPTEQQPRLENLLRESPKEKLSATRPWFDRNAFGGAVALLAVILALELFALHLRHEVDSSAADLCGTLDCIEHARALNIDTGPSVLPCRCFGCFVCSGWSNDFRHLNGSVTEQAILRWIATVHKLSVSDYDRHAVINRPLSMMRHCMSSTTDEESDVRMLTAFVSQRSFAWPTPGQVEEIVDYGRALEVVLELSVVWALPLWFHVRMLPAAASAHLQRDRTVLLSPSTPSLLARFTHERTSSYEDGYSMYTIFFSETLFALRPPSESFATFLTERSGAVQRQIFQELASATDNHLPQPKLVEIGRMPKFVRNLSAKDWVRALRSVYSTRAPHINENDFVLATNADLLKAMDSIFASNTAQDIFFHTVWWFVQALGTTISGVLRSSANNIPEGAYFQSLICFFHVDTTYNVLLAHINKAMLSTKERFAITSRLDKIRSVVVEKLLAYSKLKAETRRALSAVVENMSTVISPEDDFGRPGGFEQYFGQPYNGSDGGFYAEWEWSRLQMYNRDRQAAVAIGDYVAASEVFAFTGRALTGYNPVLNVISISVAALRPPFYYGEATSAMFYGGLGFIYAEGIFRAVDMMAHLLNRGNVMASSESAVTWAFWNASWCSDVREAEITFPGLPALDVTYASYLRFRDEASDLRLKGLRVYSPTQVFFATFCHCSCWTDTFKGKFSRMCTDATRNFGPFAEAFSCPTDAMAKMCAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6C2</accession>
    <name>A0A9D4T6C2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6C2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026691"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23807" checksum="4E26F7D30FA4ABEC" modified="2023-05-03" version="1">MSSEPLLLLPSSSASMTERSTDGMAKAFAYRFFGMLHVACVLEVAKQRTAEHGRRSHRTSATNAAADDALTETPQRLDAEDEECSITTYGDVLQWYRTSRRLYPLPHRDLQRSEAATLLQLQVQAIWTPVWAKHVCPEVYTTDICQHCKKARATQRHLWDCAQPPGNQQEAMPTAISSKIISREPGNQRDVVQRVLSILERQRPKAAPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6F0</accession>
    <name>A0A9D4T6F0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_020835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6F0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027877"/>
    <dbReference type="OMA" id="KQMTGYK"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7973049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="19547" checksum="9CD578CBE2674DDE" modified="2023-05-03" version="1">MTHWIVHPLRSWLGLMAITNLGAGVRCLLEQDFLRQRLFTKLKCGEIERCPEMERTFAFWSLYNGVLVLHCSIFLEQAAVYSATVCCLAVYLVYFGNEMFIHGSICMAGKAVLFPILLSGTLVWMLVARQYIWVRRRHDATEAEDNEQMEERLSLQNMRRLRRARQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7L7</accession>
    <name>A0A9D4T7L7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7L7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027384"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11891" checksum="7C7417F86A1BB090" modified="2023-05-03" version="1">MMLSKRPVLCKGPDPQNRRGPDPSLRNGPDPKNHSGIKWRSDCAGWKGPKADAMLLLAKPKRRRKRGVKHAAPVPAAEERTDEDESDSGRADRTPHIRVHRKESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7X9</accession>
    <name>A0A9D4T7X9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_008025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7X9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045996"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="308"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7982893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="638" mass="70262" checksum="4B7A8A7442A55374" modified="2023-05-03" version="1">MEPFLLYSLPPFNDGQRVSIHLFCPILWLQSSPFVFTSTVCRSLCGASFGCDLRNRVLHLHDDDGVCAGRKRSLSRCEEILGRLLSRRGVGFSTWGGRSAASGRAVSLGYASPESRGVVVAPMPALPRRSASSGAADVPTARLGYRYAGLERFSGRPRVYESPSSSRSSSPPPLPEKQPPPLPPSSQPSSFTALTLTSSDATEAQHSSDSSDIVAALGAVKNKLARKSRLSTKRELFFRDGPVPPAAPGAGGLLGLSKDSAGSLSSSGGGGGTAPPSYASSAGSREVAEGYVGFASLPNQVYRKAVKKGFEFTLMVVGEAGLGKSTLINSMFLTDIYSNEYPGPSHRVKKTVEVETTRVLLKEGSVNLTLTIVDTPGFGDAVDNTQCWQPIIDYIEAKYAEYLDAESRVHRTTLPDNRVHCCLYFIAPSGHGLKPLDIEFMKRLHDKVNIIPVIAKADTMTPEECSLFKRTILNEITQNKIRLYEFPDPEDEEESKLQKPLKDLKDITNSVHYENYRCRKLAGVGGAGEPGHGRSNKNPLAQMEEEKKDHEAKMQRMEKEMEQVFEMKVREKMQKLKESEADEKTTFEMAHRDMEDVFRKMAVDSNSKELRRSVSEDHFSSRKCMQYAAPVRKNCKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9E4</accession>
    <name>A0A9D4T9E4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_010597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9E4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027483"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="211"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7983272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="376" mass="40373" checksum="352F4563FB90CA06" modified="2023-05-03" version="1">MSAGGPSDATQGKPIQCKAAVAWEPSKPLTIETVEVAVPKEREVRIKVLHTGVCHTDAYTLGGLDPEGAFPCILGHEGGGIVESVGPNVKGFKPGDHVIPLYIPQCKECKFCKNPKTNLCSKIRTTQGRGLMPDGTTRFTCKGKSIYHFMGTSTFSEYTVVADISLCKIDPAAPLDKVCLLGCAVSTGYGAALNVARITKDSTVAIWGLGAVGLSVAMGAKERGAKTIIGIDINEAKFPKALEFGCTECINPNKLALPITQHLIEKTDGGLDFTFECIGNVDTMRIALESCHKGWGESVILGVAAAGKEISTRPFQLVTGRVWRGCAFGGWKSVDQVPELVDRYMKKVIKLDEFVSYTMPLEKINDAFKFMHDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB89</accession>
    <name>A0A9D4TB89_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB89"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10792" checksum="81F3B9E127436FBB" modified="2023-05-03" version="1">MSLVVRNGSTLWQKKEPKKPMLCFVHFSPSDHVHNPAFWGSRRAQKWSPLPISCAVQSFPPQVSLQEQTSVLVDDSYKDTAEDDESAAPWKYTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC02</accession>
    <name>A0A9D4TC02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC02"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47320" checksum="F563E3AC71109010" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAECQTAKCDKCDAKSLSVRKATDKEYGLAPQDEGDTNWLATHECQRNIECNSGRMEVEAALTMFQRSWAKHGLRYTTVLSDGDSRTFHALSEAEVYGFIQIDKKDCINHVHKRMGAALRNLVDKKKAQGESLGGRGKLTQEKIKKIANYYGYALRSNINDVPAMKRAVEATLLHMTSTDDAPKHSKCPEGASSWCKYNRALANGESPPSHKNAVPACVGAALEPVFARLSDESLLARCCEGKTQNASESLHSVIWTQTSKNGNASLESVKRAAAEAVAIYNQGRRATNESIAATVASARTAPETPVMRESARLFPNIEEQERAVPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD79</accession>
    <name>A0A9D4TD79_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_025220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000590">
        <property type="protein sequence ID" value="KAH7986083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD79"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028372"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035088"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39872" checksum="BE2943457D30557D" modified="2023-05-03" version="1">MSDRPRAPVAFKRDEENLTAGLLRVKKDIADLAREAPADIFIALEEVDFCRIYAVIIGPGETPYDGGILRLPPTPCFRLTCPLEYPMVPPMVRFLTTDSGRTQIHPFFYRNGNVSLSILGTYAGPQWTPAQSLRTPLLSIQSLLSAQPFYDSPLKKHANKEQTREDAESYNSFVKHEEHVSRIACILVLNILRILRVTLSTPDAFFSILESESRNLCHWAGELFLELHNATYTTHARTKQLNRMCEQALRDAEMICSVAFALAPDVAPYPGQEFEDCWKDVLLNQFHDVLPGTCIAQAAEDAQRINTRVLNRVRQLSDGALEKLFGAGGVEDAVHTRELLQGMEARQGKDNLIGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YP92</accession>
    <name>A0A9D4YP92_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YP92"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11722" checksum="D241376AA70A091F" modified="2023-05-03" version="1">MGTLLSKATYYYYYYYYYRAPLTQRDGIGRVAARGTRSEIHRTAAVTLFEGTASDGRQRRHDAEQHEHTVLAPPTATSERRSHGQHAAATVYGDSDRQEDPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P961</accession>
    <name>A0A9D4P961_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HPB52_000661</name>
        <name evidence="21" type="ORF">HPB52_011884</name>
        <name evidence="22" type="ORF">HPB52_011888</name>
        <name evidence="18" type="ORF">HPB52_024758</name>
        <name evidence="19" type="ORF">HPB52_024763</name>
        <name evidence="15" type="ORF">HPB52_024929</name>
        <name evidence="16" type="ORF">HPB52_024930</name>
        <name evidence="17" type="ORF">HPB52_024934</name>
    </gene>
    <organism evidence="17 23">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001754">
        <property type="protein sequence ID" value="KAH7932057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001754">
        <property type="protein sequence ID" value="KAH7932058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001754">
        <property type="protein sequence ID" value="KAH7932062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001641">
        <property type="protein sequence ID" value="KAH7932297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001641">
        <property type="protein sequence ID" value="KAH7932302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P961"/>
    <dbReference type="SMR" id="A0A9D4P961"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026360"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033949"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034332"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040288"/>
    <dbReference type="OMA" id="XRISAMI"/>
    <dbReference type="OrthoDB" id="6493208at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7932057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7932058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7932062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7932297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7932302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7971632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH7972400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7972404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11367" checksum="A9E5DFD3F8B97598" modified="2023-05-03" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAT4</accession>
    <name>A0A9D4PAT4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAT4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7934767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="96" mass="11139" checksum="F8E4C963A14B8EAF" modified="2023-05-03" version="1">METMPSALEYMVRESHIYFAHSTVRLAAYKELYNSMLEDHDSDKLEPPKLLSLSPTRWLAVYDCIEGIQKTSANYVVPEEMFRQMTANYSGAYSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCY1</accession>
    <name>A0A9D4PCY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_005715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056699"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7935290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22316" checksum="799453EBA4C7542A" modified="2023-05-03" version="1">MPFFSLQSAYQQTHNELFDIFILAPNGLMSHIFQERSGKSLVIMDEFGKGTKVANGVGLVVGTIESFISDPAACPHTLLATHFHTVHDHLPATPHVTYLTFESLRHEGELVYLYQLKEGRASSSYASLVGQAAGLSKDIVQRQQQITQAFSSKRKLLPQLMTRKEPVWNKALPLVQMLLDADLATQEGAEELLRNMPAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCZ1</accession>
    <name>A0A9D4PCZ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045053"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="1">
        <location>
            <begin position="648"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="836" mass="96473" checksum="42BDA8FCC0C527AE" modified="2023-05-03" version="1">MRYVLPEWDHDTRFKRPVDRSSSHLTISSTYSPKYDYGGMTSLEMIRSHDSYLPRNCYVMLRDYKAGHSFDTLTLEFESWGMDKLISSMLGPRPGSSKNLWNFMGRRRIPRDASAKERKEIEDSLHIADREYDPFYARLTLSIFGKTTDTFSIDESILAKIQEKAKPEEAVQSFLGREVNKKYFYMTKDIALIMPSELGVPVFFDMKQAEYDVASYQMVGFAPEFTKQGFGTGYHARTAISWPLDLKVTLAPLEGKLNLHRPLHLPWNVLNHQFRPFTFAVPYDINADPSHAITEFPKLMKPLYRPEELTEFDRHYFDDTFGVGLNVKGHLIKRGLRQAVREVYHDMSCRERFYYMAVNPHWHPRDIKIYALPAAQDPTTELDIDISYKFLEPDDERHSHFNVHDQILDDPEVPSTHVLRLDVNFKGAAKERKAAAELRYSFNHDLFNHKLQFFYEKTPFGHDDTELKITVNGKFTHTDEDEQQLAAAAEGKAVGRDRFSSTFLHWLANKCHQKQEKGIPFSYYCYRLLRYSSRLGKFTADVEWKNYKPLLHRLAKYYAKRYAYKPWKAGFLGVLGSYLTSDHGKLHVVSQTPWWRCGEKPHTNMIVTTEDGHSHEHWGVPTFSKILEPRIITVAGYTHAAEYSKLYRHKYCDLQAHSVRTFDGTLIDLPETDCYKVVARDCSPFKRFLVLARATNNPSLNKALKVFIDTTMVEILPLDDESGLVLRVDGNKVDITPEHSYSHTSHDAELFRVKKAATKWFTLDSESYGLHVGFGGNMLVVEVAPFYRGKLCGLCGDYNLDKNHELSGPDGHQYNSTLEFAKSYVVPSADCHAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEE9</accession>
    <name>A0A9D4PEE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEE9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="159" mass="16762" checksum="259A39608EA3C883" modified="2023-05-03" version="1">MLSARNRTAGQATLRDVLLATPPQVVAGRPQHGRPRSLAGTWAAGVRRFGPLSFVCRCFGSSPATKRLATYPPQVTQSGHTTSMDPHRSSAHWLTSLMGDSGGAVTDFLDEMQPATSPPASPKVEGTVSTERHMGGSPRVTVQPTSTAAPTGLRDMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEI8</accession>
    <name>A0A9D4PEI8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEI8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="538" mass="60768" checksum="CCCF24A2E9C7D319" modified="2023-05-03" version="1">MSQSKNHNSISIIQWQRLLDFDRPCGAELSLVCSIRARSPFERPPFPIHLSPSSSTLVYRRFRLLCITERAGTHLELRDIHTITCLETLIISCEGHNQRIADEIDALIERNRNTLKKFDICEVGQRRNGLAMLESLVACESLTFKSYYNNGGTPYMDGVVNLMRVSTTLREVFAQLICKREISLMGKALKTSCTLTKLSLCIATQYSIEELFAALELNKNLKEFFLYGTIYMNMTSARAAALALQKNACLQTLSMKHVILDDGEGMGQWSEALSKNCALEFLSIHFEHVGVSEVLGLCKALHANKSLKTLKLQGVIGSEEERESLARQLLEDECYGRMQLEPWTEPYLRILSPVLVSSQSATKELWLPDISQLSLESVHVLFNALASNKKVKCLAVSVKCTPDQRVALLCEMLKKNRSIEYLSIDIEIENSANEILRALTMNARLRVDRHCAECFELFFGRSCLMKKLEEIAGMSEAEVRHSVDAAENRRQERYLTLTGVVHRSVHCLPADATQFDALNSDCWRAIARYLSVTDVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFB0</accession>
    <name>A0A9D4PFB0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFB0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030406"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16572" checksum="1D99D816080B9E48" modified="2023-05-03" version="1">MNDSSLLQETAGSDGSTVEQIIRSMKTGGTHEDDALGGEETSGQTYSCPQSHPAATQEASSSPAEGERTSKSEGKIATPAAERKQQRQSSKKLSPQQMLMSELIEGQRQLRLSLERSKGKELAMHERQLKLDQAAAEREERLISVLEKMTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGB9</accession>
    <name>A0A9D4PGB9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032017"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="224" mass="24673" checksum="00E01EA61B5F1BD1" modified="2023-05-03" version="1">MEYPVEGQEVSPEELSDESWHSPGLRAQEKRRAALRLAAATATAKPTAMPTSQPSSSPPSNRASASPPHPHRRTPLPRLPADTIHVVRCPKRHVELTKLQPWHLYTALLQAACLQDLPPASRDMVRIHPINNTFTLSIADSSRAQAYLRITFFTVSGNTFTVHLYAPPPDDALRGILYDAFDDFTDQAILDDLQASNPTLTVVGGCRMGKSPHTLALMDTKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH37</accession>
    <name>A0A9D4PH37_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH37"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7942779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="653" mass="72321" checksum="8BAF4D502D8FF2F2" modified="2023-05-03" version="1">MEVVRVEGEELEPDEFGEGSGWCEIKRHSKNQQQGQQQTAATSPTETSTAAGTAVKYNRKTARQVRQIARASRMPDLPTDDYKVDVRPRGGFNVSDYKMDRIYCCLRSAAEIGREAAEEDSICLNFKQNIVVLSTPSEDRAKRYGAISKLRIGEREFEASAYRAAPENTSKGLVRGISNDESPENIVKSLVTQRNPTVLHAKRMGNTDNVIVLFDGFYVPRYVYYGAMLVRCSLYRKHIDVCYECGRLGHRADVCPNPNNKMCRGCGYSNPPQEHLCDPKCQLCGKGHLTGDRKCKAKYKIPYLVKRRQWERRTREEDAAVEAYGNGYNSSSTANYASQDRHLRREGRSASRGAIGGAGKSRSRSSARSRSRSLTGSRASKPRSKSKMRVAAGPGAMQPTGFEVSWADVAASPGGDGAAGRRDGVVVSGGGGPGPGRVSGDELERAIQQRLGPLEHTINELRRENALLRDEISKLKGGAAQRQQHKQQKRQEMFLEPQPLPPQPVPVEVNTVDDSSVETADEREDRPVSSKRAALDPERPTTEPRSTSYERLKKRIENIETSLDERFASQTEQINKMFTVVNNSVAKLAEQMTQAIAALTARMDDFEARPPPLAGRSLRATGKPYARPQQQQTPITDAETQHQQPSLSGDGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI12</accession>
    <name>A0A9D4PI12_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028678"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047879"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="206" mass="23035" checksum="7C2FCC0F1860D55F" modified="2023-05-03" version="1">MTTSSTPTYAYVKYHDGAKAIVHVSLIKKYSPSSVDDLAKKKMVYWCSTSSQEAKHSDEDFYMADVVELGLTKGDLIRRLVHLGNGVWVEKERWELLLGRDRDSLFCKELAKLVWGVPALRGRSVTGAPCRRYLKEGNAIEKPALSPHKLEAVGNINLFVLAAAYARFGRPIQRPIQNIEDPYLHSGYGIFKHLPYAAVATIASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL11</accession>
    <name>A0A9D4PL11_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL11"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029514"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="597" mass="63358" checksum="4D2DAD60D628DA0B" modified="2023-05-03" version="1">MAAATTKGVRKLERPRPLRSLLSPVGDPNSCGTPLFTPSGGVGVVRASTDMLVPVETLCASLGDGNRDAQTLSQIAGVCKLLKVKGADMDRDFEGMLDRCFSIFRNASRDDELSALDRLRLLEVIELRAMAWKGDEELVEYYTRKYTEFNAECDALDDASSMEQARAFQQVQSSEQRPQMETGKPGTTTCLGGGQPKAPSTAADDETGKWERSLPVGTQSLHISGMNEAIVNVATSVLQTFFSNVNADAFCHTNQTPSCVPSKPAEALAGQAVAKPVNGTSGIANGSENKRFVRLESRTECTSTGKQVPPKDLKSAWASNERHSQDRCSDGLGSSAQIPGRVDKEHAPSTGFKTLDTASKLGPLEHLKGLGNPAQFSSGDDGRQFSAGFVALGSTGTHTQLGQCGRLTGSAQFSSDTENQKLDPSGDFKGLASGDATDKSKQLSNLWGPAEHFSTSDKRMLPTKALGNTDVPDQSKQLKGLGGPAQFSSKADDKWQPLSNTFTATSSGASGQNQTMKYERLGASVQSPSSTEYQTVPFSNKSLGGAEGASKAQKHSTPLSSNAVEHGRQAGVKALSVNGLPAEKEQPKVLERDSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL62</accession>
    <name>A0A9D4PL62_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL62"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046062"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25177" checksum="F021AFEC1A9C9BE7" modified="2023-05-03" version="1">MFALVKFLKEFDSNRLYVVDSDSILDLHPRSTEDFDNRRVYSVFWVDEENSENTRAYEAQVLLLAESREELEKKKTSKRVPIPKIQMDTNSDDDKPPSKKQDHKEFHLAKGVIITASQAAKVLNNKKATLVCKDTAQAIWGTELLSERSVCGVAAPKARATGQLPKQPLTPTKVDVVAATVRHWGIIKGEDVSATVANITKVLSEKIQDARKSTKRLAAMSKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM41</accession>
    <name>A0A9D4PM41_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM41"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="49" mass="5668" checksum="4288B603D08CD7E9" modified="2023-05-03" version="1">MDDVHIPEEHKKVLQLGPKFCLEPNLRPVDKVALARSVSRKVEEEDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNS8</accession>
    <name>A0A9D4PNS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036127"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="619"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7948423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="689" mass="72927" checksum="7E90A1A66ACB1F2B" modified="2023-05-03" version="1">MPRKATGKHMKTGKDQRSLQQQKEISERQNVPAIEDRPLEKAKEALPCSQATSEPPATTAAPPKPASNTSAPAAPAAAAAATALAAAREAAKPYLRSRSGTRVALMTYRLYSNGPLRQAVEQQEEEDYQNFEAWLARKRATQRAAIHAAHASTSSAQTPSASPNHLEQQAVTTIGDWLLSKAKDAAPVAADLPEPAAATTPANTDAPSSSHAATSEDEAMDTTATSRKRGREEDAAEGPRKQTSTHATAATSTTTAAAAPADSPSMRDDAASLTATPTALLPQAAFAGTVGAPPVQRRKKNKRKARPKRRLPVREYVTSAAEAPTAPRPHNSTVAVPRPCPGPLPAEDDFVTVVSKAAQRRARALDAAARIAASDHGLTLAAALAKRPGVTAVRVNHRLNIVAADASTPSCLSELLAIRELGGVPVTAREPVDRRSSTGFVYGVDGDLTNAELLAGITSAVPVLSATREGASVKLRFAEPLPPERVVLLGLRLRVRHVRPRPRQCQQCGRFGHVAKACQRKGACIRCGRQHLEAESCKPRCVNCGGAHAADTPTCPRWQEERRVATLMAATPTPLSRRAVKAAVREESREVRSYAAAVKNKLLEGNTTDPGLQRPSPAPRRSLLRTASSPRSSLPAAPPATPAEDPRDTIITNLLATLQAVMQFLPEEHPLRATCLQALGTRSGAPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ02</accession>
    <name>A0A9D4PQ02_RHISA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003752</name>
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    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ02"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14224" checksum="E9C9A86004A38202" modified="2023-05-03" version="1">MEGREGERLQCRWATSRLTSIKEGPYSMGSRKSAAAQQPPSRRQRTRRMAPRRPGPAVSAPLPSKPRGCSVATWTHQQGQEVPRFFCSAAPWKTQRRVRRDLPADRVPWPFRGCTVAEAEEAAGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ58</accession>
    <name>A0A9D4PQ58_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ58"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048505"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7950970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41463" checksum="28CFF936FBDBBC28" modified="2023-05-03" version="1">MARSLRGEQTADAGRDEAGSRPPPGYRFLLPTLPTGEGMNLCVFLHGDPSKRPYRIEDFREPLEEAGVLKAVSGIGAFQMSHVWLVKFQTPEAKNTVLAKGGLRVKGGYCAIIDPCKQEITLKIHWVPFHIPGEALRKVLSEFGEVKDVRLDEWHVPGFECAESTTRVVRMVLKEGVTAEELPHLFKFYSGSVLVVVPGRAPTCLRCRRRGHIRRDCQTPRCTGCRAFGHVREDCARTYASVIGASPAVEDSHEHIMDADEAESTAPTKDEVSPHREPGGQLECAGKSPREPEAADKKMTQGTAEEQERCDLMEDSEAPAKRPRKDAPTPNEGGSDRKQQRRERPSLKASSEKGNTSAMSRSASSSPVRGERRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQL8</accession>
    <name>A0A9D4PQL8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038266"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="16860" checksum="3FEADCD5D3524840" modified="2023-05-03" version="1">MMSANINIEMMAIILKPQPEVSADTKSTFCDQADKHLLASRQSLAEGVNALLKKANTETIDATRADIAGIGHSGSLALQADGASIYHSGSPTCESADDGKCSTLTPGTPPERRADQDEVALAVVGSATVRSDGDQLDQSSEMPSKNFKNSDSSNQRVYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRK2</accession>
    <name>A0A9D4PRK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_004428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039272"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7951034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="385" mass="41453" checksum="099665523D1C800A" modified="2023-05-03" version="1">MCAKARTIVGYYKRSSTARARLQEIQKQLSVDPPLELVQDVPTRWNSEFAMLARLLKLKTAVTIDLTENDSVENLTNGEWRQVSAFVTVLQPVEEATTAACAESYPTLSLVVPLVHCMKLLLCDKTSDCDEYDFAQNLLKSINARFPAVSTTAPNRLATLLDPRFKDVYATVTKKKMEVRALVYSVLKEMSGRSADVEMPADCSANQSGQAIKAAPASQEWRLRYAALNTRGPESCLLEPERGLCYAAFTLYYFDAAAGTCEEFLYGGCGGNANRFGSLEECLATCARASDVAAADATPKPPKAAHRRRGDASSSSAAAVVSHANGPAGLQAAATTSRTTPAHAASKVAVNRRRKPPSTDDGAAFISPDLFPSLDGGQAWDAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRN7</accession>
    <name>A0A9D4PRN7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HPB52_004725</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
            <tissue evidence="21">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033156"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035723"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="156"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="20">
        <location>
            <begin position="1014"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="19">
        <location>
            <begin position="1543"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="801"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH7951094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1618" mass="180051" checksum="3D70624D985F72F5" modified="2023-05-03" version="1">MEPLIGYRRDPDGTVVASGLGGYVYNLVVNSLKIKHVVLIPRDHVYAGTFPNGSWAGCLGMISRNADLAIGPILPTITRFMVAQPLPQYYFIRLTTCAGTRRLFKTDVFGYVTALDTQARAFLDSVWATLLASMLLLAILMSVPSAGGRSRMSMFADQLMDLVGNMFFEATPEPPEDSYRRWLTSFWWIVVMVVMTGFTGIMKASMMVKDQAGRINGIHDVIERPEIKPYLIDGSTYHRLFSRLWRQVQRYRSVTSATEILSKQTFDEVLDEKAIFFCDDIMLYWTVARLYPNGVDGEFYLGTDFFINNEFTMFIRREFDKGVIKKMHLRLRWLWDAGLPQEWNRRTMEAALRHTTDTQTTVVAAMKLTDVGAIFYLMLFGQAFACTAGLFEVFFGMLLPAATRALAQRRSASDSPHAVRTGRRLSAVEAPTRLKDDVTSTDYRRQGNWLLMKNKNKEVSRPPKVRPPNTVQATDTIRQGMAQATNASAKSSGNDRAKTAIGQQLGNSAREQKMSGYPQDANHSQPGNIRQDLTRPQSPTTPQTPVQPLPSFQPEVNRLPQAPQYQRAPTYRVPPNSTQAAGYAQDPGYPRLAQYLQAPKYPETYAYPQSASNPEPSGYQQLYPQAQNDPAAFVYQAPPAYAPSSGQTYLQGLPPDMDPYKQVYYDAARNGILPQAPWNAGFYYTEQPSNTGAPWQAEPPHWMQDNQEPRRDMRSVSVMTSFGPTDSDRSAGVTHHGTAFSCKVTPSHHVSSSTVERSTGGASLQFLDFTWGAPERAPARGSYKARVMPGTVAKDVGLETKPFSWSSRGPLKHRDPTITQQFKPATEARREGALYSGSSSAHEESSRATEPKLTGPVVLNTNLLRSATSDNDDAHQDIGSPGSLPEELDTTSPPVAKASGKKYSKKSEDAENSDSEASAGQVDEGRNPETGVSDAVCPRDELSSSEFMSAKDKHAPSRSKPKAAASIVSPPSRTELTSEQEEEADKAGEQMDKELRDLELTTVELYPESRLAQQFSTDTLLQASMETQLLAFIKDRAHADVTPARKLYNMCMNRGAANAALLDAKKLLRQWGSDWPQKDSANISPTDVWHFAAKLMQVLGVPSLVGIEIGLDPWNIDLNIIELGPPRTVFFSKDVSEPRVMKLFSDATRTAAKALDPNDASAANAAAKDVSIALASISLLQLDDLGTSPLDFQVIKFTSLGKGVQYFLRTVFANIVTLDTSTRLLVHRSPLVRRELDETVNSLPPRAMLNYLGLLALVALSPFLPEQLSSLRVLHSVHTLGRAEIGSNDVLCLRAVSQAYPACLATASQALYKNTHRSVWLSQLESLFVGYVRNVVWMDNLTSLFVRYKMQHHRLARFFPVWPLGDCNSTTRAASSKAINAFVDAVRLRQTQELEQVPCKASAASEHRLTVVGVARYRLCLQLFQIPAGLVNGSVPANSSVFALHLSRLAVRLYAALAQLLYEGTVYEREIPLYFTEEAERTLEDLLDCLVCDARRRFPHGLRAERVRYALLEQVLALQLGFLAFRRLLSVRRIWSFDFRFSTLPEVSSDQLFFLYYALDHCELSDAVFESHQFEAYRRLPAAVRVNMAVRQSTQFAQAFRCPSTSPMAAGELCQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU80</accession>
    <name>A0A9D4PU80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_005155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU80"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029899"/>
    <dbReference type="OMA" id="ASATYWD"/>
    <dbReference type="OrthoDB" id="6481042at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="114"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="632"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7955930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="802" mass="89818" checksum="7E41BEE59EBCA971" modified="2023-05-03" version="1">MHHQDECQGQRAEGDARVPRPASRSGQGRVSSVPAFAIVLLSTAGCTIVLGVTGVVYTAQPRPVSTKNESHERRVEIRIQASRSKLATDGACESRFCEWNRDYILRAADPSKDPCDDFYAHACNAQRWYRVGSRSTRPFAELGTAQLMTDMEHFFRYFVQLKGSPIEDNFLSRVMWISDACQNSTAPRTNMSAELEEMFNVLGLAGGLPVRVVARGKLAELVAGGDRHLQLQPLFKVRVLRRREPGETGSFDIVLSAPDTLYRRFLTNFVDSTDSMYTDFVAKTLSLATPADTRSTARKIMQLEKRQESFSLASADELMMPPREKYASIDDLVLSDNWDWLVYFNSLISNANISNDTKVFVSDPIYFRNLGSVLGGAWDAIVANYMAYKAIVELAPVLGQDAEYLLQFSHSYDVPDLGERQTACLSLVEKLFRYGVGVAAKLTLGKEFATTPRSYMDAQLEHLFNVSRHMISGLVDSGRSWLDSFDKGTALRKLSNMRFEFGAQCNLVEYELYRRNHAAFNSSNPLPLSDEVGSDNFTSHSWDQQPLPHVVFLFYSIASATYWDAWGSATSRAYDNRYSLTAFRTGYELQHTGNLLVIPHATVAFLSQMSNVVHPVVYGVVAADLVRGLVEALARSGSSVDADSQARFWWSIGTLDVYENVSTCLQSQYQPPVAEGARLRSLETDFLDNAVAYPLFQLYRDSAIDLGNVSVVSPHGAEEAERPLTMDQMFFYNFAAALCDFRDEDLWQQQRKFHITPAPWRVNVPLKNLRAFSDAFACKPGSPMNPAKRCIVWKEKRSAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUU6</accession>
    <name>A0A9D4PUU6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_005685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036952"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051841">
        <property type="entry name" value="MT-Golgi_org_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902:SF31">
        <property type="entry name" value="PERICENTRIN_AKAP-450 CENTROSOMAL TARGETING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="442"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="540"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7956021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1342" mass="149998" checksum="532E902D3489362C" modified="2023-05-03" version="1">MAYLELNVEQVNKAAELLPYDTQDIDPLANVVDPRLDIRSSKSSAAGSTMPFLAESEQSRRSSVASSAGSTAGKAQAPPGPPIGAASPATNGTEQLPAASPDDPVYPNISPRVAEYVATENPTLCTQVAECIEKHSLVHSPRRAQAAPASSATPRSPLKCMAQAADALAVQQSTIGVPLKPSVPTKAIYQELVEYPPESIVASVDERTSWLRTILSSQAAARNHVQSPQNGSAKPNPLLRNQCTITRRELPSVHNWRRPSEEPGFDADNFDSASMCSETESNLSWVSDVDDEIRMLKSMMVPRASQFAVLTAREKTATGTQTDQLSSTGSVVAHVGIETDETDHFAILKEKVHLEGELDTLQGELGRLVQAKSELKTRAAAAEARCQKLAEEKDAAVQREASLQQELQTLKMESVRYGRVVGDYDSLIHSKESETGFLHDEAAVLSNENRELKVAVEELKVDLESRCGAIEGLKKKIAEMHVESQSAVRARAQLEAENASIRNQLQVIEKSKDWFRDQLHESQQGRNQLHKEHVATQAEKIALESTAEMLRAENARLTQELMEARHRSVRDKESLMKRLEDIEADLLEREATLSREAAEAQPQQPVSEASDLSSKLRVAELEEQLRSAESSLSERSAALSALERERTELVTEVQRLRLRLSDSELGRRNQDELLREGVQKVRRLQTELAASEERATELRNQKAALEVALAAANEDKRVVGESLGTLTENLARLENNFKLIRTEQVAKTAQIDQLQREKASLGERLSETETALSLARKELASRSNAQSQAQAMEVSQLRKQYSDLQNVVRVLEADLKKAAAEAREATTRHGVDKEKLRQSEEQLEHAEAELETLAQRNAVLQSQLHESAQRLVREEARRVASLQEQAQLHDPSTWETRVRELEQTLATREMATREQERMHKSNIRLLTRKLREKMKELKLAQVQLANAESQQEEDQQRRKSQKPVSQEVQTLDQPEKASAEAQTDAAAKIQEEQTELAEKNQELLLQLEREQGRLAGSLKAQEELRACVEQLERQLSEQGGCMAELQCQLEQVQGRADQVQALHQSSVADLQRELEKERTLSKELRQRIFEEKRRGGQLQRQLSSLKQGLSEASQSADAGRLKAQAQAELAQSLEAQLREAQGRLEGLRADLAASQAARQELEAKLRNAQERDPALEQQMKLLSWNVKEKTQEVAALQERVRLAETAHQAEVAGLRRQIEEAQQQHSDLSAELMSVRKEKFTLQARLQELRNVLRSRMEQCKELQRQLTELAETTEFDLPNVVPDFDDSYITELLQQCSSQPTSRPLGSLQVCLDSLKQDLNTLHSQIRQNVELPKKVGFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUV4</accession>
    <name>A0A9D4PUV4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006591</name>
        <name evidence="2" type="ORF">HPB52_006592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUV4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032367"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17870" checksum="1002C09663524E20" modified="2023-05-03" version="1">MLKGFDSPILRPERRVSFVQRLSKHRVCVLCREVPSRVIPLPCEHVGCYGCVAVACRSLKDKRRPVCPDDGATLVIHKVRVVDNSDHLFQKTVLCLNSPFGCPHQCKLEELQGHCEECQFTLVTCELCEKDVRKCDYKQHYEHCSQRNPAGGLAIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV22</accession>
    <name>A0A9D4PV22_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048652"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="380" mass="44351" checksum="1473DBD806FAD9E8" modified="2023-05-03" version="1">MKMNHANGAIVRIKLENFISSTSGRNTIIERKITGSKSTWKVNGIVTPQKSVETIVAKLNIQVSNLCQFLPQDRVADFVRMSRQELLEGTERAVGSSELFDLHQRLKELQQKRGTLEATLQGQKTRLEQDRQKVSHLDSEVKKIQEHKEVQHRIERMRQKLAWMEYEDARHLFLDEKNKLRDEEHKLKVKEQEQAPLQSTVDKLSKWQADIAATDKQLFSSVKHELRRKIQEEEGRNERMKKYVDEIAGFEREVAESSREDVEEIKRLNDLSNQRLELLRRRSRDAYEATVWLQQNEGRFKGKIYPPIMTQAGSPFFDAKYVETQIPVKDLLAFVAEYPEDLNSFLGTVRDTRNLRVNGVVVPSESLESFKPRRPLSEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV38</accession>
    <name>A0A9D4PV38_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV38"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029642"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049029"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="851" mass="94822" checksum="729E5F81CAF66609" modified="2023-05-03" version="1">MPVLLYNLVGSPPCGFIRCLAKEIGVQLSLKDLDFGKGEHRSAEFLKINPFHKVPAIDDSGFIVYESNAIAYYLLRKYAPESQLYPNCIKTRTRIDQVLAAVNGNINPSLGAFLIPCVNKAKYPKLTAYYDRVKSALPYFDEIYGPVLTLIKKLWDRMNSREKSDQHHTWFQIIHCSPCHCFALLAGGTRGPEFARPRFGLAILKSKISVGKPPPRGCGTKPVVERDPHLQTMTITLYMAIGSPPCNMVRSVAKHARVELRLKKVDLANEEHLRDEYFKDAWGVPDRLDGASSTTMEVVSVEGEDMQPEDFTNDAGWCEVRRRNITKTSEGTSGPKRTMLRDAAAPTGAPGDSKWKGERIIRQIANASRLPRLPAEDCKVIVRPRGGLSVSEHRQACIYCCLRNAAGVGREAAEEDSICINYKQNIVVFSTPSEERARRYGAITKIRVGEQEHEASAYRAAPENTSKGLIRGISQEESSEDIIDNLVTARNPSILHAKRMGNTDNVIVLFDGLHVPRYVKYGALIVRCSLYRKHLDICYECGRLGRRADVCPNPDEKICRGCGVANPTQEHQCEARCQLCGQGHFTGDRRCKAKYKISYLVRRRRWERRRREEAEAETPHGINDYNKRARKATSENTQGSEGQRTEGSPPGPYEGNSQEKPGRRPTSTATSRLQSTQGEAQPQAQVSFADAVSGTAVTPTRAGEEVKMLKVENAKLKNQKHSEMTHTTPTPIRASTPVRAPAMPVPAAKENADEQTDSTLGEVKGMFQEMSVGLQQQFMQMRTDLQQQITQMRVEMSQRFDVLEGRVAQLENVSKDARPAGARPVKSKPYSRPAAAENSCIENSRSQHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVN6</accession>
    <name>A0A9D4PVN6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_010677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054706"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="976"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7956577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1315" mass="131770" checksum="411D5EC00BC0B3DF" modified="2023-05-03" version="1">MRHDLDIGCSQNRVCNVDGVLYRSGDPIPTEDPCETCKCRPPGFACTLRECEVKPNCKAVRREGQCCPEYHCGCEQDGKFYKDGEVVPSPQSPCYVCYCQGSSISCSLVACQFRGDCEPRYVDGECCPRYDHCPPTEDPSVTTTVQLPWSPFTSPRSTGRFFTTRFQPTTIPGTGSSTHVPGGSTRHGAPVTRFEPTTIPGLSHRAPGAITKGGVLFTRTAFPTSTESTKTTERFRPEQTAFPSSLYDDLSSPQPVPDVTNPVKRYTTHLPPPEETESTSDAAGGAQSTDSMKPLEAAVQSQDVDDKLKSTVGKDAAGTTAAVGGTDGEARTVARHIFPATIVPGAAVPVVPAVLPEAGPVVIANVPVHPVVTTVGLGTVQPTVTGTVLHTDGGVGATSSTGIQGGAVTGEGALSTSSGTVMAGADHSGTAPAVETYHGAAVDSAATTGASVGDATHALAASDATTQDDASSPMVTATSELHNGASSTGAVTDASTSTSGVNTDSTIHAMATASGHVEGTDQAAPEGVTASQTLTPGAASVSTETTSTSGPTDPASTAAGNVPDATVTHTAEAGTGGATDLSAGADASSTSAHQSDSAGDTAKKASDCGSATMLADAPAPASAATDSSATNPIDSKSGPTTGEAGSAATSSGAVPAKASGDAAPVTGFADAFPAASNGDATSASAPGNDAAATTTADATPAPASGDATPPSPSEGAASAGGAGSDTEVGSATFGSRGSVQDGESSGSNDITPAPPASPELTTPATAPSPSVTEDKATEQESSSESNAEQPAVQGADQTTTTAASVVPEAVSTTVGAASVTPSSTEAATFGDSQPSMAAEEHPLGDEPHHDEGVGYSTEAPKQEDKPVTDAPASPPVDEHPLGDAPVVPDVKTEENEAVPPKDSNESGAPQRDEKSNDVSDSAGPADSATPVEQGPATDAFGAGSGTDSTSSEAPKSEDTTVSQNVEREEHPEGEPEATTAQPAETPITTTEAPHPDVDTAQPGETPTTTTEAPHHDVDDDSGRTPVSETPIVPEEAHTVSPDNEAEKPEASTEPPQNDAPPSDDAATGDSGAPHDDGAAPETPVPAAEGGGDLPPIGAAPAAPEPAPQPAPTPKSSSGNGGGNGHGHEHKPHVHHDYGGRVPPTIEQLLAQLSPDTRRQYELDHGIISTPSGGEPPANGGDSGPPKTDTEGGSADGDHATPATNSGDNQPDTTTPSSADGVGHDGGDEDTKTNEVTDAPKATEFPTRYTTTPPSAGDNGHNGDASGDDDKTKSEDATAAMTHDPIVQLVKAGIPDLHLEGAEPHRDRRRSERRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW46</accession>
    <name>A0A9D4PW46_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW46"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12352" checksum="751A0681086E6727" modified="2023-05-03" version="1">MEELFCNSGCPKTYSQDILLQSLADTEDQLVETMQALEEERKLLICDQEAKREVQYENRKFWSYCGKVFVSLVFLETDMLRRPVVIFLSLNSAHVYDQLQRVSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW61</accession>
    <name>A0A9D4PW61_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW61"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21852" checksum="F07421972E1E30F5" modified="2023-05-03" version="1">MDNGMFRTCFRFEKEDVPKLRVALRIPETVMTAQRVPIPGDEALCITLRRLAYPNRLKDLENFFGRHKVLRHIDEKFFHLLDDVNNHSWLTIDTLENFSKAYTKLEKLVQGHHYCLYGDPAYPLRPLLLKPYGGASLTPEQCAFNKAMSSFIKHLFHTLNKVQVFLLATCHLMFVLSFGKRQLALLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWC3</accession>
    <name>A0A9D4PWC3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWC3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046654"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="242" mass="27482" checksum="CD89286F4CF5241B" modified="2023-05-03" version="1">MAAVPWHIIEDQEDTFLQRPDRVCRPGARGIFVTPVEANFTRVHCVVLGPAQTPFEKGFWHVLVKFPADYPSSPPRLLNLTTDAGNVCLHPRLPGSGRVDLKILKTSGQDGAWSPPKTPKDVLCALRYELTKTESSRHGTREQRRLFDTIRHETVRVAVCGNMEAWLGNAPNIPQQLRVRVCAAFFAHHEWYVTKMQKNVHLDGQKMSTSLGDIGNFHHELLVQQLQNFLQVEIDFDELDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWD6</accession>
    <name>A0A9D4PWD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039264"/>
    <dbReference type="OMA" id="VNSNDTW"/>
    <dbReference type="OrthoDB" id="9973021at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22110">
        <property type="entry name" value="F-box_FBXO42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052821">
        <property type="entry name" value="F-box_only_SRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="582" mass="64395" checksum="2A4AEF428CE64C01" modified="2023-05-03" version="1">MSTACIDDLPEVVLEYIFCYLSPYRDFKSCRLVNKAWYAHAKAAERKLRRDFLNSVSLQNVVWCQKPTESGPTISKRYSHSACVLGDSMYVFGGCTIANTTFNDLWRLDLATRRWIRPLTMGTYPPPKACASLVPYKENLLLFGGWTHTSPYPLHQAWRIFRHLHVYNCSANRWTQVSTVGGCPSMAGHSATMQGHLMVVFGGLHCANPVGPFSSSNDIWVLDLQSYVWSKQRTTSPKPWPRYGHSQITLDEKHILVVGGCGGPNMLLNDVWLLEIFDDPEKPWSWKEVTVTNKEHAAPQLSFHPACKVGDRVVVLSKSQRAYASPSGLHPAGLMRVRQAQRVWVPPIEQPARPPPCDNQRDACVNGTRGVLKRPLESPPSSSSSTSTSTTLSQPSTPQQSPPDFALPGSSTASSSSCDEEDETSDDVARRLSSKKTAMSTVGSARPSVRPNARHNRQRQLELLDRMEQRLKALRAGGASSVPVRRRPSLPVCPMRLYVLDVSQVAQAGKASWLPLLPQAAATSTSSMVEEVILYSLVLGRGELILFGGIQKDLVNKQEDTDGTSEVVSSSLHFITSKRDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX60</accession>
    <name>A0A9D4PX60_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX60"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="237" mass="25591" checksum="ADB1EED656DD9AAF" modified="2023-05-03" version="1">MASSMECCFLKVNVTPSQRTTAKPYEPWVLVNRDGTISPAHCTCVAGIDGAHSEEDAGALVEVSCYVITAIWLTSKAFGHRRKEARKVAGLRDPLEEDGTLGASLKEPTARVAGMQRVEGAWKRGICKRQVPIVIRSALRSGKPCQDSQRQHGSGLASGTIRRRGAQKTAEHCCIVAIVCMDDTDNSSDAGVSANALGRTNELKLKIEALKLELEIEKCKSSRASQDAAPSRSERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX69</accession>
    <name>A0A9D4PX69_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX69"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033020"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055414"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="33275" checksum="A58650A6B8EA0B57" modified="2023-05-03" version="1">MTKHVVPVTTGGVAPAVTPEVPETLQHSTTPASAPSAVEPERVETDVVPVGTADTTEGQGETAADSEDEMCVTSATLKRPLDDSGEQDGASSTNSQEAPAKAPQGRRLRVGREVPPTVKPSESTSVEAAEKSKASTEQWPPLTEAADAKVRKNKDLCATPDDNDGNKPADMDISEASTSSPSAKRDHEDTGEATTNDDGEGQPPKSAKPQRQTAGAARGPGTPSRHVNKDSTIDVQKKDTATKTAPDTSESAGSEPIDVTKAGGSIGKRTREESTNDGTKTDAMNSEEPPLKSAGMRRLSIRPTPNIPPDKRTAETAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYV7</accession>
    <name>A0A9D4PYV7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_008575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055392"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="397" mass="45232" checksum="C7304761E0A1DD75" modified="2023-05-03" version="1">MTTNISGNLRYNSKLYKDNNELQRGINLKAMDFLHMTFAPDDNTENQQFLDIGCGTGDFTRDWLLPRCSPCRRLVAVDASEDMLSYARTNSSHPKIQYDYLNIGDDVTDFLGKYRTFDRIYSFFCLNWLKDQAEAMRNVSRLLTPSGECLLLFPAWSPTRTLWKEVAQLDRWKKFSNDLEDDKARLSYLRNTLDSAGLAANTCELLYVKIDFSESIQTAVDINLSVNPVLALLSPEEEELFRKDVTNKIFNGFMPKSQDLEDDKTTLSYLRNILDSAGLLANTYIQLSVNPVVASLSPEENELLRKDVTNEVMRPPQGIGSSAEPDSRCAEAKPRGLKIEVITWRNEQRHCCVPGCRGDSDGEKAMRVFAFSADADRRRQWLKAIPRADFVPGNTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZH4</accession>
    <name>A0A9D4PZH4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZH4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18313" checksum="D8634C2CC8FA37D3" modified="2023-05-03" version="1">MPHLASTAAVTAKISVLPPMRVPRVTKTWRRGTPGLGLLDAGGLLDAGVVPDCDTFCTYVSADADAVTNEELTEAEIVRAVTGVVNDDSDECVDDSPEPGVGEPHVPTSAQALDAADLRRRFFGAYDDCEDGLNIAAAAEKAIIRLRKTRRKSIKDFFFLLSELPAGVQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZT3</accession>
    <name>A0A9D4PZT3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZT3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047750"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19932" checksum="421CCD8B67708EEF" modified="2023-05-03" version="1">MDVAFSEAHCLPKIPRPALRDRGNPMELYDEEQFHARYRFTKNAVRQLLAMLPLQESGDNRGQPVPPMLHLLMALRFYGAGTFQTVTGDLIRIPQSTVCRAVGKVTLLIAKHLYSMLVRFPQPAGFPKVMWDVYEVAEFPSVTGCVDCTHVHINSPGVFTLTNHSPTEYKTCGRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0U4</accession>
    <name>A0A9D4Q0U4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_016071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0U4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038355"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7962438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="22808" checksum="F0A7A5F1A264708D" modified="2023-05-03" version="1">MSKPPSDNLTTYKLVVVGDGGVGKSALTIQFFQKLFVTDYDPTIEDSYIQHTEIDGQWCILDVLDTAGQEEFSAMREQYMRKGDGFLLVYSVTDKQSFDNMGHFHTQILRVKDRDSYPMLLVANKVDLVHLRRVSEEQGRELAQQLKISYIETSAKDPPINVDAAFHEVVRIIRNQPPQLDQKRRRKWWKNSRCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0V5</accession>
    <name>A0A9D4Q0V5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0V5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="387" mass="42387" checksum="2D48E49A19BF8D56" modified="2023-05-03" version="1">MLFAIASSVVTYPQATGSQSAPDALALNSVSRALTCLESRGSRRPLVALTPERLLQLHVLLRRVRHVTGSRLRERVVLTVLVHCRCRSRRVSSTSGVQVLPIFGKGAGCRCLFGFAGDRCDVYPGRCWLMHCFLRDCYSARGARLRCVCDRALYGTRVLSGLYWYNDGLQGAYKPPPPSWVDVVPMQFDDDLEAYAMDGVDDEIDLTLYQQAVGAATSSGKPGATVVRESSPRESSSNDTPDQTRTKGIAYNKSTSPVTFSGGASWVPLGTGLLNKTLRLLPKYELPRIAKGARLLGQVVLMRNASTKSTTSKLPGPEREIAARNVKSTLEKDFGGDAKFVYEDYAAFDEGAMPGLSQSSAMNALGSSWPLWVVACRYVRRSWQQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q130</accession>
    <name>A0A9D4Q130_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q130"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047385"/>
    <dbReference type="OMA" id="HENENCE"/>
    <dbReference type="OrthoDB" id="10313199at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="17103" checksum="4D9B889383C28274" modified="2023-05-03" version="1">MALGNGPSGELRCADKNCNEQLADKGPKYRLCLGCRRITCLSCNAQHENENCESYKARLDAQERAGRTEASTRDATAGPSKDWHAIYMNVPADFKPGEEYCCDVDGCMFAVRLHEGSTKFWCPMCHSRHRIEGDKLIRAKAPPVFPILSDFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1K3</accession>
    <name>A0A9D4Q1K3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1K3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055033"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17785" checksum="E019E34BBA37170E" modified="2023-05-03" version="1">MADSGAFIKGLLSSCNELFGNRAELMGPLEKAENMPMRWTPYVTFVAKLLQAFDASGAGDTIVDGDDEMPDGSGRINLYPQMECLKSAMAATGKAVQRMEPHLMRMLMARMRDAFLEAGTSVRMRKILLELIDLHGSGWQLTPAQQMYYDPARSFQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1P3</accession>
    <name>A0A9D4Q1P3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1P3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="433"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH7962350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="545" mass="59845" checksum="BE0D944DE1E72D69" modified="2023-05-03" version="1">MQVEGQVLPTEEFTEDLGWRTVPSRKSRALTKPGLGDDGSQGEMAERRGAGERREGLVIKQRIVKASRMPPMPEEHIKIVIRPRGGLNLEKVSPTTVGRAIVEAAGLTTEQTTEDVICPNFMQNILVASTPERNNAERYVRIRSIRVADKDFEVSAYETAPHTTCKGVIRNVDIMDGPVTLERNIVNDRNPLAMAVKRIKNTGSVIIVFDGLRVPNFVRYGPTLVRCYLYRKQVDICYVCGKLGHRADVCPAPDCLECRGCGARNPEEDHNCEPCCKLCGGRHLTADKQCRQRYQVPYVVRVRRQERARAELAAEQEAAEAAQLASVPQRSRGCSRSRSRSKSRRQSSSGTPAPRSRSVSIGGGGGAAGGRATWADKVKGSINTGRTREQSQEHVSGNRDKDRIAQLEKENHSLKAAIEGLVKEIAELKRSLQSANSGSSGQGSKPDGPVEVPRSVEVAKENMADEETPAPKKRALSSTVRVQAKIQVAPPAKASLLCTGRAAGDRTGFCRRNAPFADWDFRLRCDRQAEVLSAAGPLVRREQRL</sequence>
</entry>
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    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
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        <lineage>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1V1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052043"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038691549" evidence="2">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="15894" checksum="F3042769772787A7" modified="2023-05-03" version="1">MRLQQASALVALVLAATLIIATQAVYPDAALYQTNINRQSSGVGAAAAGGIASTITQASTNFVFTQGLSGLMSGLVSSLPSMLTNAVPMLLMLGLGGLLLPLLGVSLFFREGQKRTFSLPSINPAILDGLADVLDRVTKAIEQGEKKYATKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2L9</accession>
    <name>A0A9D4Q2L9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018461</name>
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        <name type="common">Brown dog tick</name>
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            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2L9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047213"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039593953" evidence="1">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22224" checksum="16AC489DBA9B71FB" modified="2023-05-03" version="1">MQQVIATFLLLSVFLITAPAYKLPEDDFTVEAAFGVSSREAAEEAILVGHILRIAASELEKDDTEDNEVDEYSFRTFWAKLKEATDADEYFFRSLWENIIGAIKKAAQAIWNFIKELAKDIKDATKEVGIAVLQSAGDTLREKATEKALAIVSKIFDNGSVTTYSSDKYHSNTDVVKDISARMDLVGKHLIEQGNAILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2N6</accession>
    <name>A0A9D4Q2N6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2N6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030936"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="317" mass="36181" checksum="3455F97EF0B79D81" modified="2023-05-03" version="1">MRRSGHLPFRRTQARLDRAYVTPSLQSAVVDCQAVDPPSYALGISDHRPVVVTRVDNRLFSDETARASLRNRLAASTGDRSWDALKQVWRDICTDEDSVCILGISYRASGATSESWEEEVKELKQQITRALEGGWNIPSAVVLADTYALKKTLRVLQLPEEHPARKLATYFLGVQSRLFLQTQPPGPKAINPTPFYRHVIRIYKRIAALNLDTPLLEYRNTELAQELLVNSGCEAKNPGFPWVLLTPSWLPGSIQDVVWRFGWSVLPTADRMYKWHYVRSEQCVYCHKHEDNKHALITCRVAKVFWSLVDKAYYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3P3</accession>
    <name>A0A9D4Q3P3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3P3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="375" mass="42541" checksum="4CD9FFDE76A55865" modified="2023-05-03" version="1">MHVVAFRRDFYADAFFSLTNSRACGVGIIFASSRFHQKAHCTFGANGRMLMLDMYVNGKRVRFVNSYAPVTRSDTNTFFKELHQLLLEPLAHVLLGDFNCVVNSHRDVRGPGQGKSTYHAKVLVKILVLPSDLAGKSDDVPLVTTLRGSPGPRSGNSGWRIDPNLPQDEDSVERVRDRLRESLENAPPVTPLAWDRLKEKWKSIIQEEGKAWKSRLTAQLNEILRRMKIIRGAELVQSTRDYLDTLEVSYTRLLRRKTRRPTSPNDQHDTPPYIDLRDVCGNGGVQITEAKRPDGSITVNPKEIAANFRIHFSTLFDDKDAREEDSATRQIKELCQNLRRPDEDETTALCREATLEELSGAIRCMPPTPPQDRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q532</accession>
    <name>A0A9D4Q532_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitinase II/V-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q532"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039224"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Chitinase II/V-like catalytic" evidence="2">
        <location>
            <begin position="218"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="653" mass="71012" checksum="DE83E6DE4D4DE1B0" modified="2023-05-03" version="1">MEKLTPYKSPTERHTCVLAAARRLFIPTLCPFQAPAGGFFSWIPKIFAAPDDQAPDQHIEAPQQTKASSAAGLPVHAGAAVQTTTQSPSTIIYGSDEDTDSTTTSVAVEGRPWEARSLCCVIFGMLLMPICLFVLSYYLTPQDVGELPPFTSPTSYTGSTSSITMATLPSIFPTLATPSTADPWAGVSPQCFNSRAINDNISGLNLKAYKAFGRQSSQKIFCLYNNSRFLRGHLYDFVPENLPLDYCSYIVYWSLAVANASASSRAQQFDAKYGLWRLRQMLQRHKLAQKVGVLMALGGYPEDSVHFSRLGRDPPAMGRFVSSVIQAIYAHRLSGLTIHWVASQVTCRSADDERTMSTLVGKFREAYWLNGWTRPSKLITAILPADRQFLRSTAARIVHHLDFAFFETHLIRPRAATLRLCVDVGFAALSFLQDISHIAQSDEKICAGISMTPWVLDLRNGSKLADSASKYTAVPGTASLFEICTVTTLCLDTSELSCNVLRIPLTVSSLASTAVPSMASSSTSDMTSSTTPDMNNTVDVNSTIDANTTIDVNTTVEDTTMGTSSTVSVSATTGAKSYQPGAIVFHNEATLIDMLFHGRSANGNFCVLLYDLDMDNYDSRCPATGTERVSLTQLDAAINIPPLDSLRVAFPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q542</accession>
    <name>A0A9D4Q542_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q542"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13933" checksum="FCCA234A4254F509" modified="2023-05-03" version="1">MLQSQRAVLTNRTLHRTRPICHGGYDPAQLDGNVNRTAGEVTITPSFSNFLPTDIPDFAAVVELFTGTPFERQHSYHRTRRRKIFKIFFERQSIRQLKRPGWMKAARPQTCSCCAFGRPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q570</accession>
    <name>A0A9D4Q570_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q570"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043265"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="12142" checksum="49E26544E88DD893" modified="2023-05-03" version="1">MKSIEEAGFQVVRLVADNHFQHKYVHHIREWSNDASCAVRHPVDNNRKLFLAFDHFHILKNLRKQLLYANRVLCNNGPPQLGIRACTLGLIAGFLVKAAEDCISYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5B9</accession>
    <name>A0A9D4Q5B9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5B9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11677" checksum="DF7CE157DF7B109E" modified="2023-05-03" version="1">MKVLNPIQSAMKHLVNASRLSKIHRDHTRIIVRPTRWLDVKKVGTIRLAVDEDADEDIICPNAAQNILVVSTPARKHACAHAAIQQIRISECTYDVAAFLAALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5V3</accession>
    <name>A0A9D4Q5V3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5V3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="447" mass="49331" checksum="3E748BACAF15800E" modified="2023-05-03" version="1">MEVQVNGEDISPEEFLEGAGWCTIGSNTQANRANAQSNNQTRAHSRTGEGADGNRQRSRQQQRNVRQQVIRNSKMPLLPRSDFKIVVRPRGGLDVATTGTVRLASAIYRAANVPAHEAGEDTVCSNNHQNIIVVSTPHATHAAKYRQLQAITVGDRRHEVSAYETAPDYTVKGIIKGIPLEEDAKSIHSNIVHARNSQALAAKRLSNTTTVIVAFEGPRVPTYVRYGGALLRCVLYRKQIDMCHCWGRLGHRMDVCPNPQDKVCRGCDAPNPGPDHQCSPRCKLCGGTHMTADRNCRARYKTPYVVTKRQWERRRAAEEAEAAATTGPAGKPRSRSRTSSQSRSRSRSRTPGPQQHQKRRARSRTPRGTPTGDTKTAESVSFADAVKGKRAPNAEAGGKTPTKIETEIAQLTQAMQTMKRQIEHMQAQIRAKDELIQQLQSAANSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6D8</accession>
    <name>A0A9D4Q6D8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_011971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6D8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039790"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="980" mass="107664" checksum="AB01B33280CBC0DB" modified="2023-05-03" version="1">MRDERPAVATSAARVAADDRTWKMASEARTFIRSREEPSSADLRPHCTADPKTSKRSESFSLDTALIVELQNMTNEAAIRDMIRRIEQSMTLAASLAEDQPSTSTTTITLPVEPPTSTSTFEESPSKHTRSSTVDTQTPATSEETSRFTSGKKGSATRESTSSTTSSKGESSNATGKTESDWYPFCLQFKVLALVAVAVLLFVVVVLIPRLNRTRGSLARSSQERRDWSSVCKKPACHRALDSLIEPMDLNVSPCDDFYRHVCGRWRARNPKRLSYASENHHNFLMGIHRRLAGHSFDSRWNGSDTPPNHGGCERRNRIVAAFYASCLHFGRRPSIPSLRAVLSRVPKKLSFYVRGLVEVGEVLRALGDWREPDVVNLYTLLVPAAQLFAYVRPWLVPRNDREDRVIPACLRATEHRFVSVFSSMLAAWTETNRARLYFRDMVSTLRRALGNTIPDKNDLARNEVDAYVAFRVVTIAERNQSECACRMEDLSSISLSINDFIGNLILLFKEDRFTSAKQSRAHIAKAVKDGLYQLPSCLGSFVSGAGHTVIVPPLYLSGELLQAEASEPSLDVPTVGVPILISWARSIMSTGEDDWSTTAASYGSCVRKNHPLDHALSDRASDEALLTNALLVPWAISVALTAAATMTGIEHGAFSYAASKSSVTGTVDDGIPKELEEVFDIIEQSKGQMITWLKDLVAIPSVSAEKQHHKDIMRAIKETGTILQEQGVHITEAPLGDQQLQDGSKVPLPPLLLATTGQEAAKKTLCVYGHLDVYPARKEDGWTADPFLPTEQDGRLFARGVASVKGPLVAWIAALYAFRKSAAKAAPVNLKFLIESMEEVGSQGLDSYLAANAKEDFFKGINFVCVADGFWLNQRTPCLSYGLRGLCSFNVEIGSAKPDLESGADGGALHEPMADVVFLLDSLMGTRGHVAIEGFHEDVAPITDTEWKLYEHVDFDPSEVNALQALLDGTRDGCGDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7D8</accession>
    <name>A0A9D4Q7D8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7D8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037086"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049070"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="666" mass="73824" checksum="B5F5BD9BC9E1BDAB" modified="2023-05-03" version="1">MDGNADLPLEEGALTSYAGQWADLEGITGCFTAAVLKYRCSCSEAHDRPCHIVRHLAAFNEVLFSARMQLREIPGARGQLALVSVADSGMHLPEPQDFQHQFWGSPIRESICATIPSLTSLEELECSFFGDCCAEFPTALAALVRTSPSLVVLGLHGTSMEEHATNNLLSCLIQSGILKELTLRGSLIPETCREELRKYLMFAPSLTSFTFTADSEKTETAVLEGILHNKTLSKVVITTFTGGIESIQLVAGIISGNTVISSLVILSIYEDVSPIHNAAYDTWLEALGENEALKELSLPYQLWNPQQWIRFHDILSSKHHLKKVYVFSDSTNHNLLTHVCHTLEDSGVHDKVSCGVYFAEDNIDLLKCKMFSGLFLVGDVHEDVKTAALLQLPDCGHVTSLVLEIPRGNLAVSSALAEYVQSTAVLRKLEVSTGFADDFDFSDEWWRVIVESLTRNNSLKELVFYVDSMSDRDVESIADAVNASRNIRKLTFGDSTVTSLRAFVSRLSLGITDNHTLLDIVLEGRLDQEWPEASKKVLAIYETTRRNMGLLAAAAAFTKTTELDRYSSAALERICKLHGELLEDLAELADVSAAEIGGLARGHLKRTTSLDEYMRITSVVKERVVCHPRDDGRMQLDDLNEDCWVMVRRYLMLDDVEEAVGHTECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7V3</accession>
    <name>A0A9D4Q7V3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7V3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035783"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="71424" checksum="9471B8DACCAF92B9" modified="2023-05-03" version="1">MTAYHFDGLMASPPLGFLQVTSGEQREYSHTTSAPGTIAIICVFELVSLQAFSIVSKNVSGNRGHHVWQELSLTAVRAALALPGDSPAMAAPNQVTGYDPESLRIVSMDTIQTEAPMPTEEEYLQDMLRVWRGKNSAVASRDAGALAAKQQAASRSQHAQGKSAPSVASQRAKQLQWRPKNTPRIEKTISYRRCSPQHPRSRRKCGPCGMAHLEQNVLVCTLKSVNAADRLLRDITLPVGGRQLPFRGHPKLSGEFCRGLVHVSQDETSETVKSELSAEPNVVTVRKLGDTPVAVISFAGTKVPRTVLYNCERLPVHLYKKTVPACPLCGTVGHRADTCPRPQPGRCASCGVRVPAATPDGPTEHQCVPSCLLCGGGHKTGAPGCAGRFRKPIKSGSPRGSKPKTAGGHKQAPIPKTSPKKAPATKPNKPEPKKAHTGPSTNVKSGTPWKPPVLMVKDFPPLTSVQAQVSYWGGAVSGPSPSPSPTETALQQHIEELRRQNRFLARKIQELEAKQVGSSEPEQGTEIEDGDDGSSVTSDLTSVFWRNGDTSLERKTEQFEERVAALPNQIMSAVRASFQDTFTAALTQALPEIVAQVSDSVLKAVQPWVSTQIKNTTQCEPPQLKRKTASRQALEEDLSGLAPGGPVRPLMAATPAPGPGRYPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q983</accession>
    <name>A0A9D4Q983_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_024069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q983"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031048"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7970099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="402" mass="45458" checksum="CCDE1AD4E2869294" modified="2023-05-03" version="1">MARGMMAVESKVRFDSDEEFKKRAYACVVQLQSHDQDMISAWKLICDVSRREFQTIYERLDATLIERGESFYQDMMGDVVKDLEERGFLEEDEGRKVMFAKDLPVPLTIVKSDGGYTYDTSDMAALRHRVQQEKADWIIYVVDAGQAQHFNTVFACGQRAGYVDTSKVRLDHCCFGVVLGEDKSIARNVGLSLDVLRNEDVSVPVEHPKERKLAKALLRFPEVLATMLEELYLHPLCDYLFDLSQTFSEFYDNCYCIEKDRTTGKCQPMCSIMDFKVADDDCEDCDDLNEAVNSIVGGDLESNFESFAKADADVPVVAPATDAEIVDLLGGPGEEEEPLDEQPREIPTVAQTQEILRLLQSRLECAGGNHDLIIYLNKLEQALLAPSQSTRQSQLTDFFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9N4</accession>
    <name>A0A9D4Q9N4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9N4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035659"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039434703" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19542" checksum="2795742FF762114C" modified="2023-05-03" version="1">MFKVTVLLLLCAAVIGMQRPVDMLRGCVTKPGKRPTPGECVLVPRRELRTNKVYMVLAEAVLQAHSNQSTASHLNTIFNITRVARQHLDDVSKGVLLLLEFFTVPSDCMRHSFYFASHCKPLTTKVNGICQARFFMHNDFTVLQDFWCGRVRSVRMRYISKASAITKSHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBG1</accession>
    <name>A0A9D4QBG1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBG1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052355"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7975317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="46385" checksum="12B3C88913B3EBD7" modified="2023-05-03" version="1">MAASQPSSTVHLQGEATTTKLQMSHTPELSNKCMAPSTVSPSKSSAPQDVVEDGRPLYLGNRRQQVTSGIFFLLLLVSWLAVVLTHVGKDHSADPVVRPPPSHMSDYPLPPDSGALAFSAVANETVDTASATPTAVRSKNVARTKSTARSRKSTAATSAWNRLQLWRESARNVTAPPSHSGRELGSASEAKKNLWCAYNGSDSRFKSHHLPLQLCSAVLLCCLTLTTPAGEPSANNLRFAEFLKLQDTNGTTRPSLMVALGGPQQDPGVLHSLAQRDHGNASKRLAEHVLHFVEFNRLDGVLLYALHCGPDEVAVFQALYERLDYHGYTVAVTCPDGEGGPKMFADAKIGPVVLIPASANASRTQCPRGLARRVLDDGESTADVMLGIRLSGVRYTLPAGGEAISREGAAASLVSSAAYRDVCLAIKYADQVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCW6</accession>
    <name>A0A9D4QCW6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCW6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="16040" checksum="CA92C2BEA9B38A66" modified="2023-05-03" version="1">MTSELSTTASDEDVLTSALAFPDIYAKHGSLVRDKMARLIHVPGTLWRKSGGEVFVFFDLRGPDGEWDDFLESLFAKKATVIVRHASDREKDIRLPMGEGGRHGVGSQGPDDGDSILYSEKVSWQDIETNGFVVNDALHANIEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCY1</accession>
    <name>A0A9D4QCY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053814"/>
    <dbReference type="OrthoDB" id="6485227at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038984061" description="Secreted protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7975494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14617" checksum="E5794B41B2EEC4D4" modified="2023-05-03" version="1">MPLRELATVVALLVSLTSLRCASAEGLCTPSPQATDIADRATCPFKMSMDVDLSRIPSELPVTKCNCPDSLCSDKGDYRCQEVKSTFKVAYRGASSELTNKTLELTTACVCVVNRSAGAVWGGQRTTGGDPHKPAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDJ4</accession>
    <name>A0A9D4QDJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDJ4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10351" checksum="AE80628037378AE9" modified="2023-05-03" version="1">MSSGSTQVCPSKPPQKVDGVHHLAWRGQGSFDSIQIVRIFRLLSCAGNKLHYLLVAENFCCVSVRICVGDHEVIEVMICVHLVASTKLFPKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEH6</accession>
    <name>A0A9D4QEH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034114"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="20740" checksum="824AADAFB78F9C1D" modified="2023-05-03" version="1">MIGSPLGARERSPDPQRLEPGELTPVHQRSSRRLRGDPPEFGPLPTAPATQAAFAVNSRAMASPAASSELIVSPPNAPVDVLSVSQGSNSEALRELVRSIVKEELQKLLQPQVTPTVSTLATIVRDKFGTHFFNRNLRRNLSGSNNRCRNVVYQRTRTLYANPPCTMLRSQPPVATHRLRTARPFKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF43</accession>
    <name>A0A9D4QF43_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF43"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11344" checksum="90491DB9DDDA5E00" modified="2023-05-03" version="1">MEAMRKALISPGAPLLVVGDFNASHTSSSYRMNCRKGRVVWTFVQNEGFSLLNYISFSTRIGSSVQRNTSPDLTLSKHIRDSHWTNTTHIFGSDRYILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGN1</accession>
    <name>A0A9D4QGN1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_013140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046975"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7976403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43912" checksum="CE9879A3D15CD2E4" modified="2023-05-03" version="1">MAAKKMAASTVVQRNLPYLRQQFLAALQTCSAVVKVLSLAVFLCYFLSYSQVASRAISVTPGYIIPPSFWIWTAFTHAFFENSVWMVIADIVTVGLCGKLIEPLWGAIEMLTFFAIVNTSVAFLSVAYYIVLYSVTWNPDYLFAVRIHGLAGYCAAVMVAVKQIMPDHVLVPLPFGKIRNRNVPLTVLLASIILWACQVLRGTYPVMFVSGMLSSWVYLRFYQHHSNGSKGDMADHFTFASFFPNVLQPPIALVSNLIFNFFVKIKLCRKPPRKYNLSSGSASTVTINLPGTDPQDAERRRQIALRALSERLTKVEQQWPLLSDEDQSSTASSSTTAAPSLGTPQHHPKPGPSGEGPASSQVAITIPSLPLPPPPSSAREIPASRESPLDSSAKGQSSLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHW0</accession>
    <name>A0A9D4QHW0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_006919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056064"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000537">
        <property type="entry name" value="Ves G 1 allergen, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="82"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7982738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="393" mass="43884" checksum="5DCBB3C8E905B128" modified="2023-05-03" version="1">MPRFPGRLKERQTPATTDGDLDGRIKLPGKAARFVGASVELLDSVLPGNLADAINVTDTSNDSACYPLVGCFRTRDPLTVPLSFPDSPEKINTSFLLYSRQNSNSPLRLDYRSRASVERLNLFRERKPLKLIVHGWHESGDSEWVLEAKDSLLRLEDCNVIVVDWRGGSQQSNYIRSAGNTALVGREGSLLLQHLLSVYRRTLSPEDVHVIGHSLGGQVSGFLGRHFLNQTGVLLGRITALDAAAPLFEDTDVFLSRRDAQFVDAIHTSAGGKVIKGEFGILKPFGHVDFYPNELYCDHKLSKDFFLESLRSQRCRFISEPCGGGLDALLADRCTRRGDRGEMGYFADRAPGRGLQTLETNNAAPYCRERHVPRNPPRDDTPRRDRNRRPARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPW5</accession>
    <name>A0A9D4SPW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HPB52_000206</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Rsan-2018</strain>
            <tissue evidence="27">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035156"/>
    <dbReference type="OMA" id="APYCPCI"/>
    <dbReference type="OrthoDB" id="5917245at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07659">
        <property type="entry name" value="BAR_PICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000023">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000073">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037959">
        <property type="entry name" value="PICK1_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="26">
        <location>
            <begin position="162"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="389"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH7942715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="446" mass="49772" checksum="C9D507DD40306E78" modified="2023-05-03" version="1">MSDVAGGYQLVPQEDPDDSPDTFYFSMEDRMGMTVTSGSVVIQKDDSNLIGISIGGGAPLCPCLYVVQVFDNTPAARDGTLQSGDEIVGVNGTAVKGKTKVEVAKMIQSVKQKEVTINYNKLHADPKQGKTLDIVLKKAKHRIVENMSSTTADALGLSRAILCNDSLVKKLEELSRNEQIYKGLMEHTHHMLKAFFDMCHVYRTFGDVFAEIGVREPQPRASEAFTRFGEAHRSIEKYGIKLLKTVRPMLSDLNTYLNKAVPDTKLTIKKYADAKFEYLSYCLKVKEMDDEEYAYQALQEPLYRVETGNYEYRLILRCRQDARVRFAKLRSDVLVKLELLDQKHVQDIVFQLQRLVSALSQYHSDCHGVMKGSCIFPIEVDLSRSTFHYPDPSVSPYQDEEEEDEEDDELLSAGSGPSTADGNSASASSSTTLVAAAVEKSLLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPZ2</accession>
    <name>A0A9D4SPZ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPZ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036598"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19921" checksum="7A559676D801519E" modified="2023-05-03" version="1">MAASRKESARKRPGKLLSDEEIQELLFQSDIELSDEDDILDEPRSSSECSGSSSDDDDESEDDTPASHKVQGRGPIWKATEARLYWSCISAVPLVTENMTRDRFFELRGMLHFVDLSQTTDAQTENQLFRAEPIIESFRKACLQLPRPKAVSVDVQMIPFSGRCPARQYVPSKPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQU8</accession>
    <name>A0A9D4SQU8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">limulus clotting factor C</fullName>
            <ecNumber evidence="12">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_019542</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="12"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQU8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029043"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039612126" description="limulus clotting factor C" evidence="14">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7939940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="300" mass="32982" checksum="DE0EC0E53036A9D1" modified="2023-05-03" version="1">MIYFVVGVTLLLGSSSSVRADGLQINGPECGMPTQGMIVNGTAAKTNQFPWMVFLAMYTSKGSQYNCGGSILTKRHILTAAHCTVTRSGKPFKRIDAYYGNSEWTRGKRLVVTKVIRHPKYSSRNHANDIAVLQVEKPFQYGSNARPICIPAAPMNIFDTETVVAGWGRLKEGGMATTHLQFTTVRVLPNELCSVLYFILGYVGDLMYCAYRKGTNACHGDSGGPLMSRVIGGRYVQVGIVSFGASCEGAYIPAVYARVETYTPWLRQVVGSFDKAYSNEVPLQLASYTVPQWPSIFHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQZ4</accession>
    <name>A0A9D4SQZ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053792"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="463" mass="51422" checksum="508633EAF0CDF659" modified="2023-05-03" version="1">MNTVVLEHVDEDKPCAAVVPPPSAIASTIAPLMSRRSRPSTLETLATDVVVAQVLPALERVVLAQPDGGGNVDEALCEGRNPFVSCKPAIIESLIEKIQKKRGHLNLTSLQLEILLCRAGVKKLDLFLTSEFLARKDALRFPRMFRRISTFGAELTDLSLEFYLTCNNDELCAMLATLPNLRHFLVAFENLSDRVLETLGEKCPQLQKLTLCETPQDVNVFTVQTSVRPTMREFLAKSIELCPRLQAIDIEVKTSDDISPLRLLAGLTELSIRTSESTSEWFFYTQLEPVLQEAGLQLTSLKLAMPDVDLAAVDAACPSIKTLQLIAINMCWRRNGVKLRDQPFGDLEALFLDPESPHSMKSRDLGLLLNGSYTLKELVLGCCDCFDDVFVMESLQRGLFRNLTRLELHNQRTVGILGIQQLVLLDEVLESLTLKECTALSTDDLAFLTGTACALNFQLKVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRW0</accession>
    <name>A0A9D4SRW0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025979"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038975226" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="96" mass="10942" checksum="1AB3CCE09F92C50F" modified="2023-05-03" version="1">MVADLRERSAAMLDRGNGRGPAAAILLAAMLLSCAPPVALSAESWCNLEDEDPDSKWYWRVDEYPHPLTQPRYCNRYRPSFVCDPDRVMSKKQGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STK2</accession>
    <name>A0A9D4STK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039414"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7948496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="834" mass="90989" checksum="5C24939537AC4862" modified="2023-05-03" version="1">MPIARPDNLPEELWPQPSTSTACLENNNPGPSTSNAAPAEGKASSKAVRVTDAVSTAPADDERVSGAEASTGGQSTTDGEGKSCGGAVAAAVLRCPPRPRQYRSKSAVSTDPRSPYYISQGIQNNEAVRRSPSVSCVLDAIRREAQEGGEVPGVSKAALEKPSVSTIRQHYYPEGGWGWVVCACALLVHMLTQGVQGAFGLLLIIIRQQFHGDDDAYTLHAAESLQPDEFGEGSGWCEIKRHSKNQQQGQQQTAATSPTETSTAAGTAVKYNRKTARQVRQIARASRMPDLPTDDYKVVVRPRGGFNVSDYKMDRIYCCLRSAAEIGREAAEEDSICLNFKQNIVVLSTPSEDRAKRYGAISKLRIGEREFEASAYRAAPENTSKGLVRGISNDESPENIVKSLVTQRNPTVLHAKRMGNTDNVIVLFDGFYVPRYVYYGAMLVRCSLYRKHIDVCYGCGRLGHRADVCPNPNNKMCRGCGYSNPPQEHLCDPKCQLCGKGHLTGDRKCKAKYKIPYLVKRRQWERRTREEDAAVEAYGNGYNSSSTANYASQDRHLRREGRSASRGAIGGAGKSRSRSSARSRSRSLTGSRASKPRSKSKMRVAAGPGAMQPTGFVNHGNSSQYENGSYWQRQHQQQQQHQHYKSNVQEVSWADVAASPGGDGAAGRRDGVVVSGGGGPGPGRPVPVEVNTVDDSSVETADEREDRPVSSKRAALDPERPTTEPRSTSYERLKKRIENIETSLDERFASQTEQINKMFTVVNNSVAKLAEQMTQAIAALTARMDDFEARPPPLAGRSLRATGKPYARPQQQQTPITDAETQHQQPSLSGDGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU77</accession>
    <name>A0A9D4SU77_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_003261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU77"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048010"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="133"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7950948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="340" mass="39471" checksum="13F093520062C920" modified="2023-05-03" version="1">MAAHCSNLMLRLAISGAGRSLTQGLFRPSVQQVRWAKSNKHWLPKWKALRRRKVIKIKLPEFEEMRHRDQMTPEEMRAKLKEQGVAPDRPWNERTHGGVFEPYLPPEGDGKVSLLTKAGAVQRMRRLEMRGKSYMNLRKIRAYEDEFDLVEFADVAQDIYIEAHKALANRDEEKLQDLVTEHCYPIMMENIERKTLRWQFVRSLEPPRAVHVRCTDMISKENLFGQITMRFHSQQTLAVYDRFGRLMHGSEAIIKDVLEYVVFEKHISNLYGTWRLHSKIIPDWQPPKEPMRKTFVKPKPKEQPEEAPGAAETTTTTVTETRPPPPSQSSQPSGETFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVC6</accession>
    <name>A0A9D4SVC6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038498"/>
    <dbReference type="OMA" id="CDERKSQ"/>
    <dbReference type="OrthoDB" id="10048650at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="16637" checksum="9EDD4A7481073839" modified="2023-05-03" version="1">MTDSNAPSTEQTSRLQDVSAVQLRLPSFWPQDPQVWFHQVEAQFSLYRTASETTRYYYVASVLPPDVTSELSAVLSNPSDTTPYQHLKTKVLERFMPSERVRLQQLLAEGDLGDRRLSQLLLRMRQLLGEHDVSAQSALLRELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVP9</accession>
    <name>A0A9D4SVP9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVP9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051729"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 38 C-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11489" checksum="16A33C7457644F97" modified="2023-05-03" version="1">MLVVSAQRRHHIMIQIVDLMETAPGVIRLRNQFVEAKLNYICEVSSLKILGGSKELVAADKLANVFVMFDDIPLYWDAWDVMDYHLETRRPAVKQVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXJ4</accession>
    <name>A0A9D4SXJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040717"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="20575" checksum="99FE5C7F4C2E9A7C" modified="2023-05-03" version="1">MGRAIIKGNQAAQPSTSSDAKNPKQIQQHPPQQQAAGSLMRGGGEVDMMAKLFEHQRLLQQQQRAPPGVLGMVRQQQQGHPAIKLPGMMRTAGGMAAAPPAAPPPAAMAASRAHHAGGMKGVAGGSGRGPSVEMLQQALAQGLHPLAFQQFLLGGAAAPPAVGPSPFAPALHPSPAHTFVPNATGQRGEYTTSDKTRGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY48</accession>
    <name>A0A9D4SY48_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_008790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY48"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047083"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7956393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="593" mass="65974" checksum="C0CAEB21F5C8B7A3" modified="2023-05-03" version="1">MGSSEDEEPEEAEKSKECLAAHGYTVGKTLGAGSYSTVKLVSKDGGSYACKIISKEKSSVIYRVKFLPRELKILGSTRHPHITQIYTIIEEPTKVFIIMEMACGGDLLEKILKVKRLDEKTTHQFFMQLASALAYLHKNDVAHRDLKCENVLLTTVDVVKLTDFSFARYCTDEHTKRKELSETFCGSEAYAAPEILQGICYLPKLADVWSLGVILYVMVTGLLPYESNGLLRQVRLQMTRTVRFPKVLPLSQELKNLIRGMLEPVVTLRASMGRVIRHPWIKRYPSPFKEHVYVSCSLSKRRWTNAERSLTAIRPTPLSVRAAPSSKPSLRPASPSIADYTTASLLWGYVYGTGGRSAGALKEDTMAANNIDCCKVRARLMFLAAAPSHAPQAVPHSLYWAASSAPYTVPCSSAERADFAAGLRERTGLVAGNFGQCNPGSAGPPRPRERFQHWDYENPSPDTPRKFVAEDSTTALSQSSSPCRGAGIGAVQELLHGPNVFSQTSVWMLRSGVQLASDTVIYRQKLRWKRRDELVSRLGRRLETQPLRCCTSQGSRQDPLEQIELRGARDGLLSGKFAEKMNSRFSCVFPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYA7</accession>
    <name>A0A9D4SYA7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYA7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039433606" description="Cuticular protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7956663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="72853" checksum="F5686294FA493C89" modified="2023-05-03" version="1">MEMRGSWRLQMIVASWLLAVSATLCAAQQQYLQGPPPLNGGYKGYQPYGSGLAAGPQQGGARPQGYQLPQGFVPQQVIPPTQPRQPFVSQGFQPQGYQPQGPPPSASAGVQQPQPQAQALQQPQPQSTSQSSASSTKAEEAKLPVFQAAPLHYVSIGAKLEGDYKFGYDTGKGSDKTGSFREETRLPDGTVKGSYGFIDASGRQRIIKYTAGKDGFKAEGDIYQEGAPKDTIPQHLQQTVSASSSAPAPSAPAPAPAPAPAPAPATSRPETKYKPPSYTDAPPSPPVQYRPPAYPQFQPTAPPSQPSLGPSHVPVLRLAANLPVDNLAFPDYFKHHLTEQRSAAATSQPAPTAVSPFQGPPPRAPHSRATPYPLSDPVPTHLPRLLGLVVHRSATAPTAAAPAKQYVPAQYLQQQQAQPKVSIANIFAQEAQKAANKPNFADFLKQFIPRPAQQQQFAPSGGAPGAASTQPGFSPYGPPASSTPALQRPPVYLPQQPAQLKAPPNYALPQGGGGQVPLYNSFRPPLQQAPSFAPRTAQAAPQLPAYPLQRAGFYPQQPQTGYTGAPQGAPTGLSGSTTQSLKKDDEDDQDDGTYKPELYDHGLYDPKKYEEPYLKKKTSSSSASPANSAPSLPQQFYQPSGQGAPAQGQAPQQFYQPSGQGAPAQGQVEEKALPLFDASLLSYNIGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYZ3</accession>
    <name>A0A9D4SYZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044163"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="208" mass="23493" checksum="F6A95F1254F4C906" modified="2023-05-03" version="1">MNAADGPAAGEPGNADIITIWSEAENLFKDTGERRDFAPGAAARSMPALREQRKNRDFCDVVFRAPDGSEIWAHRFVVAARYSGCYALFALAKKGLSPEQKWLPPMRVTVDDLSSEMIQLLVDVAYRIPLCDLVGQHNIAEVLELAEKLEVWEEQRPVRGTYDQRRCAVILEDNRLKRTDGDGCIQRLLKWTPPTWPRGRHISRSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ01</accession>
    <name>A0A9D4SZ01_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037460"/>
    <dbReference type="OMA" id="KPWSASE"/>
    <dbReference type="OrthoDB" id="6510117at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="453" mass="50462" checksum="8398E8965355BF6E" modified="2023-05-03" version="1">MPSASPNREMDHYYSTEEDMDVYKPSKEDMDSAEQELRVKLERFGAVSDLGGTDSIVNEVVDKVSELVASPDDTAEEESKTDPLLPYLEAEKKLLCARKRTGVAASRRPLPTRRGSGDSAPLPHEDNSELFRRIASVVSGKGVEYKACSQEQYCAELVSKLTGMCAEAKPWTASSSDARYAERPTVLDRMLLKVSRIALSRLVETEVRGCLEDEDETELPKELARYVGLTAKLDAEEARRYVHVQDLSAQREERAVYVRTLLAQGERLRGARENVEQRESHVGIVIRGVCDLHDSLASRVQLCKSLVAAADNVQAVQARQENAAAAAATSVCLDDDPVGAVFDQRCSQLVAAMAAIVDQLDQMQLRRERMTELVDRLEADMTARCQGSMSKWHDGVRANTLKRNGNLKLLRALFIEFHTNPTRFVSRMKTARMLKARGTLPVVQQKKDDAKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZG4</accession>
    <name>A0A9D4SZG4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZG4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047081"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="715" mass="78808" checksum="3D6C0EA33F584276" modified="2023-05-03" version="1">MLCRPAGWASQWVPLYGRATVTRAGEVEELPNRQPIDPRSLFAALRREESQENGKADGRKRRDSSVDESSISSDTSCSSLEFHRPHSAGVEASRSPYRNSPARLDATAGCSGFTASCVKGSTESLTRRERLDAVKARVEAKRSQYGGSSSSDDDEDVTWRENGKVTKARRRSRESSAPPRPVVPAWQESKAYQEPNNMVRRAGAVTPLTVTTTFQGPAAPVQPSPQDSGVSSQSVASSPSLGRAPTPPPRRTPSRAITRESSLLAAKPRRHSASFDQWRMEDSGIGSERKDSSFYSYADLTPAHGVKARVRGPAYSYTDQAPLRPDSAGAYMSDPQRTDMRFFGLAPGHRRASISAEVLDLTPRSDTPPRRPRPLSMVVEKTRSVPPPVPRQRPVTGNTSSLEAARRRLDDVIQRERDRRSSANLETALNELEEIYNSLRLNEDEDLLFRAERRDLPTKWPMTSPIAVWPSRSLPARNGAHTPPPRKDVSYMLCSAAFTPSLHVHPALMDVSLAGEPDIEKDDMCYRNYTQADALRVPPPQPPFGIPLVPTQGTTCDYIRARPPDAPRPLTRPKVHPDLVRDDMAFRNLRKDPAVSLAARRSTRALSVSVASKATSPSDKQQDKSQSMTSIMEALQKESQRWKRLDEGVTHAPNSAPGTHNHVSNNGPDWSAARQRGKIVPMEDCQLDALLASLTPPPVPTPGERRLRTGVRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1G3</accession>
    <name>A0A9D4T1G3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_018377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1G3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="9">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7962862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="28360" checksum="DFA817F27B66EE6D" modified="2023-05-03" version="1">MGDSEWAPPDGWLHQRTVLLYDDSVAGEELAMRVDLTEARVQVWFQNRRAKWRKQEKAAGNALQSQGYNPYSTAQSLSSSTPTMAAGAHPSPSMAAAAAAAAAFGSLYGRKPPTSAAQDSALLSAARLSPYIGSAAAAAAAMPLLTPGHAFFPISPFAHFLPPVAAGAVPDAGALPELAGHAHWCLHQLHWLRQRQRRNGPILGGSSPARSSSSVSPGVTASTLSPSASPPSAAGAGPDRRSSSIAALRMKAREHEIQLEIMRKTNGEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T419</accession>
    <name>A0A9D4T419_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T419"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033548"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="354" mass="38822" checksum="9E8AA5161FD57D8D" modified="2023-05-03" version="1">MSADLTTAIVAFTLDLYKQLLSESPTALSMTLAGAKGNTAAEITTVLHTKGDMIHAHFADFFAKVATYAPDVTLDIANRMYTEQTFEVLESYLSALKKFYNSTVVPVDFKNNAEAARVAINAWVEETTKTKIKDLLPNGVVDSDTALVLVNAIYFKGLWNKQFNPEVTSLQEFRTSKESSKQVHMMYKQSHFKINTECSDLNANAIEIPYKGGKTSMVILLPHEIDGLSKLEAALTPGSTATIVDLSLPRFRIEYSMDLKKTLRTMGVKDLFADNAADLSGIDGKRDLVISAAVHKAFVEVNEEGTEAAAATGMVAMARCAIIGIPFSVDHPFMYFIRSHDPDVILFAGSVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4F4</accession>
    <name>A0A9D4T4F4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4F4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21997" checksum="44614939E4839F8F" modified="2023-05-03" version="1">MLRLLFRVIIPDGTITVSVPNLLICDESLLHPQQTGWQRWDEKKAGGHLLKGRNFDDPGSSGSTTLTRQAAKAPQRASRRSGIGRRGNVSGRQAIARSWYRVWYGSPAGWAHKQSTEEYGVVEVYKLGPSARRLTPAPGGYRHRRCRLPPEYHNHAVPGPQQKPRRQNGHQALVQSCAGSVDAFRARVQAPDKLHSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5V5</accession>
    <name>A0A9D4T5V5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5V5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056706"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="167"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="361" mass="40948" checksum="3A9B46FFA9576351" modified="2023-05-03" version="1">MEDRDTRRPGRPRKAPDEQKKKYARVSPVDRCRIIDVHRRGGDLKVLSETLGINIKTVRSIAATDRDTAKTRGGSSKKFGPDVVDALQQIVQENPPFTLEQIKRALKEEMPNIEVSTSTIDRLLDGHGYSVKLLTQRPVDRNRADVKQLRRRYAQWLQSEGTTLTRYYIDETNFNVWCSRSFGRAKRGAPACRLSTSAKGANVNVIACMSANGLVHWTIADKVHWAVFNDFLAEVSRKVSQQEPGIQAVFLFDNAPAHRRAEQAVLAASDHTVKWLPPYSPFFNPIEELFSKFKAGVKSFLSERRDDLLTTPRGISKKEHRRALLVEAAGRSMQHIQRVDCAAYDRHNYTFVQAALDCLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T646</accession>
    <name>A0A9D4T646_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T646"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036365"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036807"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="251"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7977007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="606" mass="68026" checksum="65FB69424B8211C6" modified="2023-05-03" version="1">MGVVVLGYMLWVLATTENRRFIDGVLVFTYVHLGVGAAWFLTGMCGWIGSYKKGGLGMKLFLFLAVVMVAAEIGGIVALSILKIKMVDILKSGWIEVNEPTKNFIQDRAAIDLLFSLPDDEREGASVCQLPPLEDGNITDEEHVNENDFSEVVPDDVCGHVEVMQCSDEDVDSPSACSSPEPRRKKPAGRQFTAGKGRKASTKARKTNTPERSHTPAWGDRATFDKTLPGESPPLLLEAFPELANMSPSMLGYHSVTSEDSYWSTAEDLCVPIVATVMARNRFRQLKRFFHVVDNTQLKAGEKMGKIQPFYDEISKCFRQFRVFNESLSIDESMVPYYGHHSCKMFIRGKPIRFGYKIWMMCSTNGYPYAMEIYCGRNEKDDKTPLGIRVVSNMVSVLEAPEQHEVYFDNFFTSHGLLTKLADQGIRATGTVRDTRTGGCPLKSLKSIGKEERGSFHYKCDGAVYSCRGSDAAMTHIAFRRDVTMSLLQLKPKLTVRPGPRVHPRHEDRKTDGHYMISTTQGSESEAWLDCCGFSGPKEFATTNSHIDETCYRLVGETEDVSIKEIRRIKRVTAILLSVYLINAKKRELRENSFSSLTHRSYTTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6L1</accession>
    <name>A0A9D4T6L1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">28S ribosomal protein S24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_002576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6L1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044000"/>
    <dbReference type="OMA" id="FLQGYTE"/>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7981994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19894" checksum="88E806386F81F132" modified="2023-05-03" version="1">MAVPTSSLCKVFGRLCHPAFLPAPGRVAALHTTAALQKNRAGRYRVTRNHSKPLTYEMSNPPHQIAHRKAWNSWNTSNLQGGLRRSETLVEDMFIRKFMTGTWHRMFVSEILIKRRANMIFIGGIVQRVVIPRKMYFLIGYTEEILSYILKCPVKLELQSVADRKEMVFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T759</accession>
    <name>A0A9D4T759_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="36091" checksum="59B266D2CAE81198" modified="2023-05-03" version="1">MNWTGGARSRVQKKLKQKAQQEFFKKQRLQSTLEARNNPQWPEVRGSKDLQRLDMYSRHIAPTPTALDNKVSNLACSEYSQDGPEWLQVSCEESQGTITIPQYGSDDDGLIAGVDFPEDNPPETPLLYRHNHANVLRNGQPVTMDPLFPWPANVEPNEEPMPVSPVDLRIQYLHGTGVMELRDMDSFYKSAWVLQLQHAHHQLYMEEIKAQVLYEPPDRFSIMSAFEDVDDHFAGRKSRRSSLRYKTLDDELQVLSPGDSPTSQGVMKDARTRQCPTPGRVHLGEPTRCSSHGKLSVKNRTSKAAPAAQSQEVEVKDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8B2</accession>
    <name>A0A9D4T8B2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol phospholipid synthesis protein scs3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_002176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8B2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040804"/>
    <dbReference type="OMA" id="TYRFWYL"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03230">
        <property type="entry name" value="FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046401">
        <property type="entry name" value="FITM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7981950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37113" checksum="0C26F051216DD95A" modified="2023-05-03" version="1">MAGNQKRSRVSGAMKWDAAAAKQTATGRKPLGEPMSVPQVLVMVGLHLCRRVVVVEPRVKVPLYLGVLLIGSVMCDFFPIPRTYLSRKDNVFNIYFVKVAWGWTLTTVGLFVAVSSWVYCCGDRALVKRHLSRLAVGTAAWFFTTYFFVAFEAYTSRCVVDKHGTREACLRAGQRWFGFDISGHAFLLIFCNLMIAEEARCFCGWERIGDLLRNEKYDDDSPLKELRAEQLRLLHDAYPRLTPFVRLLFVALTYLSLLWDLMLVCTVLYFHSMAQKILGGLIAIVEWFVLYRIWYTMTWSPGLPGQGLFKYRDVQRKKSQGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T945</accession>
    <name>A0A9D4T945_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T945"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048338"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="315" mass="35843" checksum="A62320D93DB426B0" modified="2023-05-03" version="1">MKPNNCSRSNTPTKRDTPAPSNSETVQQKNNAASCRVEGVVESSSHHPYGAVKKHESSMRSQCCGYTCRPRMETQVEQSSEYRDIAVDSSGRGLREKSSYYLAIDFVEVMAGGEDKRTSMYTEPYYIPRPNHRRGAQWMKSTWYFDLKTIFNGWLETFGCKLRERGEYVPTVRVVEYPENMRHLRQWVTRIKLPSSAFMITSTRKPFTDRQRPKGDIHLALKSDKVSSLPTVAQFTEAAAPQPQPPPMLYYSSCLPTDMPYPIATMIPPPATERLQNDPALVPNWTPPTIDNSVLAWQLAVAQTTQDIPLRDRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAB6</accession>
    <name>A0A9D4TAB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056453"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="143" mass="15475" checksum="52EBA08C13EF60BE" modified="2023-05-03" version="1">MATALSFADDNPVSEEDEADAPSYVGQEGGQVELPCTVLHARDAATQASPVRVEWHRRDDTDPEPVYAVYFSGRANLMQGRHQPRKDWSPRAYFAVLGSPAALKVKALGLADAGVYTCRVTRSDGSVQASIVRLSVLGERLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAW8</accession>
    <name>A0A9D4TAW8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein big brother</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAW8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028705"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.250.10">
        <property type="entry name" value="Core binding factor, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003417">
        <property type="entry name" value="CBF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036552">
        <property type="entry name" value="CBF_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276:SF3">
        <property type="entry name" value="CORE-BINDING FACTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276">
        <property type="entry name" value="CORE-BINDING FACTOR, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02312">
        <property type="entry name" value="CBF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50723">
        <property type="entry name" value="Core binding factor beta, CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7983991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21451" checksum="E60DA8B865E2DD26" modified="2023-05-03" version="1">MGFGSAALPASRRRSNERRPEEGSGSDRGSTWPRLSIVFTALPWRRPADDVLSNGMRPTPRQHDLIPAAAEEGKQAATLAVHIKSSFIMNGVCVRYRGWIDLDRLDGVGCLEYDEERGRLEDAVLRDQIECYNQRLRDFEEKQRAFRARHERQAEAELECPPPGCTLSRDDNRIREDAEKGPSERWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB14</accession>
    <name>A0A9D4TB14_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BING4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB14"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026939"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BING4 C-terminal" evidence="6">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7984112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="416" mass="47541" checksum="2C842B8068A084FB" modified="2023-05-03" version="1">MSRYFTVQEDTSEEISHPLANADDTSKRTVTKHGKKKDQMVKHTAKKLKTVTTSPADENTAAKYKRSSHLTLKGIKTRVQRKKIQADVKKVRKSVLQAARAELLLPEDVGYLQADDGEETFQLLQKDIADAVDITSCTKYFDLNLPQFGPYSINYSRESRHLLLGGGRGHVAALDWVTKRLLCETNVMESVHAVQWLHMPTMFAVAQKSWTYIYDSQGVELHCLKALDSVLRMTFLPYHFLLVTASEKGYLSWLDTSIGQMVAQFNAKSGRLNVMKQNPYNAVVLTGHTNGSGEPNFDALESNPYMTKQQRREMEVKALLEKVQPELICLDPKRLGKVNVERMQEKVDEANKKLWVKPRTIDYTPKVGKKSAKVKQALKDQHTKEHVKRLRQEKKAETRKLKDRSSRDVLDRFKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBT5</accession>
    <name>A0A9D4TBT5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_022152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049766"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24679" checksum="C35A0522A00F8EB8" modified="2023-05-03" version="1">MPKNRHRHCYAPGCRTGYSGVKVTRKVSLFSVPKDEDRRKLWEKNLHRSDKPLDDQCAVCELHFEDRYILRDYIHVVNGEEVRIPRGVPALTCDAVPTILPNAPKYLTKKVPAERAPRKREPSAQLQSERRKKKRDASPCGTTALQDNDDDDCSSPRIDAENLGQLKAPSTCWYALPVLPLPPKSSPDQNLLAKVPSSQEDQDSYPEVKVDSTKTPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBW3</accession>
    <name>A0A9D4TBW3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_023294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBW3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051716"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7984624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="258" mass="28421" checksum="6BB8DD341CEBDD16" modified="2023-05-03" version="1">MSLSLVFFRYFIAIDESFGYPAAELEVPEQGEVQCPSEADGPPAKKPALQDASSSGGGAKEEGAAQQEQMGPVLAGPGALKATPPLIGFGLMKLTPEQLEMVTRAKKFAMEQSIKSVLMKQTIAHQQQQQKTLQRHQALVLMCRVYVGSISFELKEDTIKQAFRPFGPIKSINMSWDPVTQKHKGFAFVEYELPEAAQLALEQMNGVLIGGRNIKVGRPSNMPQAAPILDQIMEEAKTYNRIYIASVHQDLTESDIQR</sequence>
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            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000978">
        <property type="protein sequence ID" value="KAH7985353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031743"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16949" checksum="A076FC3F61F48B96" modified="2023-05-03" version="1">MTCQRVRLSSPQLRDPEVFALKLPEFLSSDSKVWFITVESLFRRHRLTSQLTMSDHVVGALPPHPGAVVRDALLAPPADHPYDHPADTLIRSTTDSEQHRLQQLITLEENGDCKPTDLLRRVQPQRPISLHLDHHPSRKFSAALSNTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCZ4</accession>
    <name>A0A9D4TCZ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_025520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000804">
        <property type="protein sequence ID" value="KAH7985618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056930"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7985618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="14083" checksum="DAFF98FA84911634" modified="2023-05-03" version="1">MLRLAISGAGRSLTQGLFRPSVQQVRWAKSNKHWLPKWKALRRRKVIKIKLPEFEEMRHRDQMTPEEMRAKLKEQGVAPDRPWNERPMVISCSGGVFEPYLPPEGDGKVSLLTKAGAVQAHAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDK9</accession>
    <name>A0A9D4TDK9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin Y-type LIR-motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_025037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000479">
        <property type="protein sequence ID" value="KAH7986344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDK9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042858"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000012">
        <property type="entry name" value="Putative DE-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin Y-type LIR-motif" evidence="11">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7986344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="18957" checksum="56ED62A95A128772" modified="2023-05-03" version="1">MVKATHASAMKASSATTAAALTLVLGQHDQHIPALGLEALLIILACLVVYLLLVLVIVAYTRSRRSDQKFGHGGVDDDVRENIISYDDEAAPTGAHPDVGDFIRDHLDKADQDPGAPPVDDLRNYAYEGGGSTAGSLSSLASETDDHEQRFDYLNGWGPRFQKLADMYGQGESEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE82</accession>
    <name>A0A9D4TE82_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000117">
        <property type="protein sequence ID" value="KAH7987116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE82"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7987116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="17674" checksum="2425A35D1ADBC267" modified="2023-05-03" version="1">MEEMVVDPCSGRDRPAAARKRLSSSVASEAADSESDVRSDDSDAFVPAKHRRSRRKSTTSSSSEETVIYNTIVTTTVAYVPVDVTVSLNAISKQKLDDFFFKLAPGLIQEVRVNPRKNIIAVDTTDEKTVQTLLGLSQLCGVNTRAYIPQERQCNSRSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YN95</accession>
    <name>A0A9D4YN95_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YN95"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053103"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="37675" checksum="36F77C6B4B0A0512" modified="2023-05-03" version="1">MRTSRVLNIAARSAWPPLDGGALHAPPPPISGKRAKPRTDSERRRRPDAPTSDRPNTDTEPRNSGCEIAATVEFVSASQRKIGFFESERRPVDAATANTLLCEIDALTALAAGAQCPTCHERKLGVREAAGKRKGLSAFIELCCQNSDCPESALSVTHTSRRTTSAGDQGTSARFDSGSSRDSFAVNVKAVMAARAIGAGHDHLSRFCAILGLPSPMHHKTFNGISKKLHGAAMTANAAESLNSKIWLLCPKTKFASRTTVETATALRVLWYNKGHRGFEKVPEGIGILPSQDLATHGDHCDVMRIRKMNLKQTAEARAHRRNTAKRARVKDTDRKSREGPSYGAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YP64</accession>
    <name>A0A9D4YP64_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_011530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YP64"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035285"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
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            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="18"/>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPQ2</accession>
    <name>A0A9D4YPQ2_RHISA</name>
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        </submittedName>
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    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
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            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983652.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
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    </evidence>
    <sequence length="210" mass="23889" checksum="81B3E19714586141" modified="2023-05-03" version="1">MPRLQGARWCDGADKLYDAKGNGSGIAEKWLLLSRNDVEALVDLPASPRQRRVEAAERLQGLFPRSEQFFAVRLLEDEWQYQARVFRESLYLKLHSTYRLTTATQQFRFFSGMANRTTEFVWQHTLPHQRALIPRRPVSSGNPINTFGDVVLPEFGRDVLGMGPKFAVPPRSSAPELVTYVRQVSRLANEAQTDIQIVLEVGFTSPVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQ36</accession>
    <name>A0A9D4YQ36_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
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            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQ36"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046734"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="14114" checksum="845E97C2A413012E" modified="2023-05-03" version="1">MLASSATPFSVKDILNLSDSGVDELDPQALLYQAQSLEKAFFEEACHEGLLDADALLLPAAADSAAASTAGGGQCAPHLCLPYHAACFEGGPGLDPGYAQQDETPTPHLAQHCAIARTDMLCQQFASDASKRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR48</accession>
    <name>A0A9D4YR48_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_023534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR48"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030113"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="6" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="239" mass="26816" checksum="77398DBB723B6EB6" modified="2023-05-03" version="1">MLYGVGTDVSVLFEVLILPTRLHLLVRFHGVECETFTRCSVPLRNRCETDDASLCVCAQVRRLSVTMADHSELVTEMSVVEKMSTQERLKHAKKRRQQQLKKWSQHERELQKAKKGKASSPAAAPPPTEYKVHFVPSVMLLEAAARNDVDEGRYPLCHTRIIQSGGLAYRRSLWVGARRCHTTRCEHFSRLYRARAAGVRMVSIAPRTPAGYDGPLTDARAVGLHGHGAVFRAMTAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRU9</accession>
    <name>A0A9D4YRU9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000306">
        <property type="protein sequence ID" value="KAH7986717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRU9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10571" checksum="0EAAA551981C251E" modified="2023-05-03" version="1">MSLAEPDAQLTLGTTMPQGQADPPNIGRNSHTADAPVTQSLRCACPGLAQERSRVTTAYRRQGLPASTLEHLLFPSRPLPALRSLVEFLDETGIAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBX6</accession>
    <name>A0A9D4PBX6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBX6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056586"/>
    <dbReference type="OMA" id="VRIAHEC"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000005">
        <property type="entry name" value="TatD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7935438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31913" checksum="F8D75EF04C256F9F" modified="2023-05-03" version="1">MALRESKKWPYTVASTTGLIDSHCHLDYLFSKANHFGSYADYRRENQHTFPDCYEGCVANFCNPVTFKLEYMWDALLSEDKVWGAFGVHPKMADEYNDQIEQQLLHALQHPSVVAFGEIGLDYSNKNRDEQQQVFRTQLQLATSRGLPLVIHSRNATADTIRIMREMVPANYMIHVHCFNGNWNEALQWLDPFPHLCLGLTPKLEQSGDLAEAARRIPLERLLLETDAPFFLPKDEKGKSSVAHPGMVIHVATKLANIRNTTVGEVLEAVRQNTKRVYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCR0</accession>
    <name>A0A9D4PCR0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCR0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="270" mass="30424" checksum="1244820066C6CDC8" modified="2023-05-03" version="1">MDRASRAIRRSGARLKALNGGHADLNLVISELRDIRLAMKSFLTAQNAVAQDMVLWAQADENRIIQDVMAQLAELNALWTDIQKDFVEHLKTFRHQFELILEGERQVDHSRSALAACEQKELRIKKELKRAAKKATVEEISNLELKLAQAERAKDLAQFETLEKVQEHEAVKLIRLKQGLLQLSDAYLSLANKGALLFEAQREIAAHMPDVPPHSALHDFKYTGSGAMKQAVQRAKDRVEQYHCYQYRLIPHCPSVGELVAVAAAQSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDB9</accession>
    <name>A0A9D4PDB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDB9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38545" checksum="51ECD7CC5566C1CC" modified="2023-05-03" version="1">MLPLGWALAAISDVYYIIYADDITLWSVHNDLQRQESALQEALNAADEWCRCIGLTLSTDKTLYMSVANSWGRRRLVNTPIQLTLSGRPLTPAPQLRILGVVITANGSAKAWIREIKQQAHQVLHLIRRISSKAGVPRPTTTFRRHIEEADAALPTGSLVAYTDASCTDTQVVTSIVVPGHQNLCVNRLYLLRGPVPSVSAELLAIRDATKLVSAASASSSSFTIIRTHSTSAIKELRKKRRERARLNMEKAEAHDPSCDRDASNDALAILYVGLAGQGCVAKKRTGDGSGSSSTRKPVTRASREVTGRDLDPVGGALLGMQQAHIPITDLSCASPLEASRRTQPPVGHVGSLHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDU0</accession>
    <name>A0A9D4PDU0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDU0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="131" mass="14582" checksum="3E3AABDA4F9C3CC4" modified="2023-05-03" version="1">MEERRISESGLAGCTVPSLSFLMLSRQDWSLGRAKASSSAGCDDAEVLEVAEKRSAQWCGRTAAPSIQRILTQSRIGILRLACRSSWAWLRKRSHLASFAAAASEYEFAEKFTTNSHRDRNNPPLWTPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE54</accession>
    <name>A0A9D4PE54_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE54"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="18340" checksum="F206EE53911D3DC0" modified="2023-05-03" version="1">MNCAKPIVVRLSTGIRSMNSIMTSNDNGSCDNELAQGWYRFETPYGNRMPEQPASPGMCNTMVPFWFYGRHPPQPSMPMPAVACGADETDSCSYYANIRVQHCGTYMAYYLQPLPRCFMAYCIGERLSRRRYRNASDIFAHLRNMTTEMSTGATSPDANEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEA8</accession>
    <name>A0A9D4PEA8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_013260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEA8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043955"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="242" mass="27353" checksum="147923761D88B8DC" modified="2023-05-03" version="1">MTDSRSSHNCDEVVLDTPSRRNLEDVNADSVAENNARRRGKRPRSSSTCVPHSPHRSSSTYLLRGFGSPFLDSAPVTFLRQLPSACICAGCRSIHATPARLPCGHTLCEPCRDVAYSGQPKRPALQDQETREVSRYGRCPVDGDAFSTLDFDLLNFSHEAVYRGTVFCPNAELGCRFRGELRFLEYHCLNNCRFRIVGSSGRRECHARDVIRHILRRAAESSRVPQREIRTVKRRLLSTFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFV6</accession>
    <name>A0A9D4PFV6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_018881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFV6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038980"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057933"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000230">
        <property type="entry name" value="Leucine-rich repeat-containing protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="255" mass="28480" checksum="17DB54A3BACCEAE7" modified="2023-05-03" version="1">MGNSLKPHIQNAGKTGVCTLPNSNLKEFEQLKHLTLTNNRIAFLPDSLCKLKKLETLSLGSNHLSRLPETLSQLSNLRNVNLSDNRLAAFPHCFCGLKHLDVLDLSRNRISEVPDFVGDLHATELNLNQNQVSMISESIANCPRLKVLRLEENCLQINSIPTQLLSSSNVSLLAVEGNLFELKDFQEKEGYETRKHCRRMICPQRPTPNIGKLRPGCTLMRRKLAMTNPAGPRSTKLRRGPSMIGVHLTDTVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHT9</accession>
    <name>A0A9D4PHT9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHT9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="404" mass="45215" checksum="CA6ACD4EAF3F7AFE" modified="2023-05-03" version="1">MWPALNARTRAAPTSRWAVTRVTLSNESADSTASEVSAAFRAITLPLRALGLPLVPLTEPATASTRKICPLVGLVIFAYAVRLLVAFFAREHDLSSFRVLLALGHIFRSFTSFLSVVHFCLHYRLLNEVVTKIRAIFDAYSHIAKLARFIKLLSAFCVVCAFVLWPALLMNAFMQNKAYPYAHYDNGIRAVLVFIDTFLLSLSKTLSSFIIVLFVGLCYMLSNSTLRFMLTLESEFTNARAFEIKAVRKALLRLSRISDVANALNRTYGAILSWWYAEFTASFLLGVPSCIVAVSGGAQFSEYAFSLVDLLRDMTVFMTMTFVASEMAKNVSDSLHYALRVTNTIEDRNVDLNFALLLENLVCHIEDAKVELSGAEFFHVDRALINRVLLLVSTFAIILYQFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIG0</accession>
    <name>A0A9D4PIG0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIG0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047750"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18040" checksum="263456496D6C1445" modified="2023-05-03" version="1">MELYDEERFHARYRFTKNAVRQLLAMLPLQESGDNRGQPVPTFIEPVPPMLRLLMTLRFYGADTFQTVTGDLVRIPQSTVCRAVGKVTLLIAKHFHSMLVRFPQPAGFPKVMRDFYEVAEFPGVTGCVDCTHVRIDSPGVFTLTNHSSAEYKTCGRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIJ9</accession>
    <name>A0A9D4PIJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048663"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="478" mass="51773" checksum="EB7BBB412F41E5DE" modified="2023-05-03" version="1">MLPSLCPPVKPFHPAYPQAWFMQLDAILALNGITAQPMMHAVLLQALPVELNHLASATTYSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPHGPQPSHDHDLPSPATTPPTSRQATSASIPAPEHPPDEVQEVPAASGHSTESFVFSTASAHGPSDVPAICTSSPTSMAHDTSAASGSTTATSPHALESAIDRDIVTPAIRPPIVEASPAMISDEPVFLSTSTLCASYQQRPASPSQSLAAEVPALNHRWPNIRDAATMTDAPEDDVPGQHTPELTAYDTPATEADIQHADLRTSPREPTTVGASTSTGSPSEPAAETTPAQLHHRFPAEPLTQDTIHPTSDRYAGALVATATTPNRHSCLPHATLRRRSHRARRQTQQKLHTRPSTLPRDAAISLKGIYALRRHPFVRRRVPDTHLRRRAPRHMTQWSTLRRRLQRHLHPLNYICGHLSQPRSLSTTGALPKGPIKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMJ6</accession>
    <name>A0A9D4PMJ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMJ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028314"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41099" checksum="5225F51E13157C06" modified="2023-05-03" version="1">MALANDPPDATARPGPSKMMDTQRQDLDNMDFQDSAAHSFPTPSGPSDQNAGIDSQHQADGAWQTVLTLRKKKALAKEKKAKSVDFSGTLNHQQASTGEATGKPKHKPTYRRLPPLPKDDFKIVVRPHQGLPVKNLTSPLLADAVIAACGGQISGDQFLLRIKPGSNIFIVSTPHQTVADHVRRLTTLSINGRPHSVNAYVATSEGTTKGVIHGLDPHTTPEALKANLRVRTQGVEILQARMFRNTKTAVITFFGGITPRYVYYNGGELPCYSYKVTTQVCKVCHQVGHRSDVCPQPDTPVCHVCGQRDPVAGHDCTPKCAACGEGHLTGDRSCRKRLKPQRNRTPKGSSHQPAQNDTSMKPPQRLPGGPTTNINQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN65</accession>
    <name>A0A9D4PN65_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ornithine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043314"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="7">
        <location>
            <begin position="193"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36229" checksum="E8BB65499A9985F0" modified="2023-05-03" version="1">MNDDATFISSLPTREFAKEIISNNAKDGIENPFFVVDIDDLFYKIDLLRKHMPRVKPFYAVKCNNDPVVLEVLASLDIGFDCASIAEIETMVSLGVDPSRIIYAHPQKHVTYLRRAWKQGVDLMTFDCAHELYKIKEHYPSARLVLRLKVENRKAWFRLGDKFGCSETEAVELLHMAKALEMAVVGVCEPGGFVVSSAFFLCTKIIGKRMCESSDEIKQAVCMYYINESTYKSFMMVIYNEEIARPEPLEEVVRPTQPSMVWGITCDSSDKIKAACSLPDMDVGEWMAFPNMGAYSTTVTSPFNGFPDAEIHYRASKCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNS7</accession>
    <name>A0A9D4PNS7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_018365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNS7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036251"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06492">
        <property type="entry name" value="p23_mNUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="147"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7948084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="311" mass="35992" checksum="854A030DF82AA955" modified="2023-05-03" version="1">MPESDVEKFDGMLLALAQQHEGGVQHLLETIFSFLARKTDFYTGGGPGSARKLILEKFSKYESMALAEKAEKEKKSKEAEERRKAKIKKDKEECTVEEITDAEAEALQKELEKEKEEKAKRAAEAEKEAKEEKKDKGKLKPNAGNGCDLENYRWTQTLSEIELRVPIPRNLKIRARDVVIDFEKKHLKVGLKGFPLIIDGDLFNEIKVEESCWILEDSKTILVTMEKINKMEWWTRLVTTDPEINTRKVNPEPSKLSDLDGETRGMVEKMMYDQRQREMGLPTSDEQKKQDVLKKFMEQHPEMDFSKCKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNW5</accession>
    <name>A0A9D4PNW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_013955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030405"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7947603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16363" checksum="EF29601FFE8A5E8B" modified="2023-05-03" version="1">MLVRSSYFAYKDLRRYRALAQNPYAQVQVHGNVTGLSPGRHGFHVHRFGDLTGGCKSAAAHYNPANADHGAPSDDIRHIGDLGNIEADVNGVALFSFYDRLLALEGPQNIIGRAVVVHEREDDLGRTTHPDSRSTGNAGGRLGCGVIGIAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNY2</accession>
    <name>A0A9D4PNY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNY2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025724"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034444"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="684" mass="76999" checksum="B41D260BA0D0FE3D" modified="2023-05-03" version="1">MYILLQWAQNFNNEDNTVCVEWLDGDTCRQVDTVAYNSYRATATRTSRPEAALPNADVAGAGSSAHTEVTDAAPRVTEGTPGPATVPLLPKLQIPTFSGALRDWQTFWDHFSATIHRNEDLLPIEKFKYLLSYLSGAAKRAIEGIRLTEDNYAIAIRTLTERFGRRDLLINEHIDHLLALPPVKSSADVDKLRLLYDKVQFRVSALTGLGVSPDQYNVVLNSVLMRCLPDDLAILYRQKSKEAAQDTSGIATPEERARQVAEMLSFLRIQIEVREEGRPGRTPSAFSRFLPDEDVEPPSAPTGHLPTASALAAESVPITEELLCDKNYDAADNFHPDTWYPQEVSVLLGSDVYWKVATGKVDHLTSNLTAMETKFGWTIQGTTERERSSAFPRCDRGGPPSQRRPFFRGFALQTARPPRYTRVLQGGSGGGFDGARGPRRGFGIRPPFHGNNDTSSRDYDHTRYGDCRDDAVDGPHSLPDRTQQGRPQWRQRGRSVTPPTQPSAWKENWRTRTSQGARSSNDRRGCWESRSFYYSSGSSDSETDRGRRHPSGESGRETMMATSSMARSRNVAAENSHRVAVRSASESRELTRGAKRQRESHRKRDWSVRAKKTAAQRDQGTRSHWERVPITTRRMRFRLRPAFAKSRIVWNPLLSSPRRLQLLERKLRGKTWTLHAGLNAQDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPB8</accession>
    <name>A0A9D4PPB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_015142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037499"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054223"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="210"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7947681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58405" checksum="971BF2B7D95C34DB" modified="2023-05-03" version="1">MSKATEPDGLETLLERCFGIRVARQELEAPTTALVIRVLHGAFSTFGLSDVALEVPCSLLPSEAMHIEGSIPLGHYLKLMQAVFEMLGVNDVGLQDLTNPKPKRTRRLFKILVNKLLHTTTVFTKYMDKLHQQQAAKAKGEQALAELNAVTAKANKMATLLHDVGEQEKAVDSELLACGETLAAYADKKTAIVSDYQQLKTTLCASTEAVEKAQLHIMELQEALEEKRASLCRDPPAWKEKILTDAETLAALESEIEKLRSVVSAVNEKVSLAPRISEEYSKTLDSITGMEDRAAEVEMLQQRKATQEKKRIELEQAHYALQKKVELAAEEQKRLDERQPYDAGLQSREQRNNDARQLLQQLQTAMKQTRASAIAKVFCGVCTNTPATATGPGALCFVRATSAEMSEIEETTDNCDTGGDVDFAADITGPNDWDADASLEQTAMEDENGEVQNGDAVTGDAEAAAEFQASVCYLCDVTAVSKSQMAMHVKGAKHKLRCANLRLPPSALDLPGTNRAAKSPTKAESKSAGPPDPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQC4</accession>
    <name>A0A9D4PQC4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQC4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037232"/>
    <dbReference type="OrthoDB" id="6482665at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11206" checksum="ECD37795AD8A476C" modified="2023-05-03" version="1">MYDHGTTENQVRYSQATPPPYPLDRVRTQFAIFSSEGDPMAHPHDVDYLVAKLGDNVVVHHIVAQPTMRHLDFAVGYNATEILHNVAIDVVRKYTDSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQP3</accession>
    <name>A0A9D4PQP3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylcholinesterase</fullName>
            <ecNumber evidence="2">3.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQP3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033363"/>
    <dbReference type="OMA" id="ATDWEFY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038887487" description="acetylcholinesterase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="157"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7950953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="686" mass="76125" checksum="5ED0BA946159784E" modified="2023-05-03" version="1">MRTWVLCLLLGLVCLIAISIATLVLQLPPELLASAGSEKDSGQEGPPLVPEKRKGDLAIIGPANDVSGTSDDGDRDVAAGRPESLLAPQDPLPDAYLVPSTGNSPDTPSRGGSNNDLETNVDVLSATDISIAVEAETTPTPVTSPPQLPEATKDGRPLVNTTTGMVVGFKTEVLGRKLDVFLGIPFATPPLGELRFKKPLPVQRWENVLDAKEMGPPCYHISFASSWSWAASKKPESEDCLHLNIWTPDTTGRNETKGSTQLRPMIVFIYGGGFNIGATDWEFYDGGVLAAYGDVVVASMNYRLGALGFLNADIEDIPGNMGLYDQHLALRWLHENARSFGADPGHVVLMGESAGAVSAGLHLISPMSRNMVKRVILQSGSPLWDTPDNTADGVKKATEFAEIFKCSNSSHNFQDGTTADDVVRCLRDIDADALFRTAEKALGKRVLTYHPRHGDDFMPINAHEALKKGLFKDSDVLLGVNKDEGSIFVANTLPYIFLNGLAPNITKDEAAFYLIFFFQYIIRTGTRDIRDHYFKNIKDRDYPSVRNAFIEAIGDYLQICPTIYYGEVYSEFNNSVYFYHFLHRPSNSYWPEWLGTAHFDEVEFVFGVPLRFPKQFTEEEVLFSRHIMDIWLTFTKTGKPPAMDGIPWPRYSELNPVHMELSPKRFRLGKGLHADHCRFWKKFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRK6</accession>
    <name>A0A9D4PRK6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRK6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="377" mass="39681" checksum="2CBE8F20CFB8E50B" modified="2023-05-03" version="1">MLPSLCPPVKPFHPAYPRAWFMQLDAILALNGITAQPMMHAVLIQALPVELHHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPHGPQPSHDHDLPSPATTPPSSRQATSASIPAPDHPPDEVQEVPAAIGHSTERSVFSTAWAHGPSDLPASCTSSPTSTAHDTSDTSGSTTATSPHALEPAVDTDIVTPAVRPPIAKASSAMSNEPAFSTSTLCASCQQELPSSSKSPAADVQAHNQLRPNVRDAATMTENPEDHPPCLPQSPLPECADEPPASQELVCVPISLGCTAEFLGPLPISKSSVSLAPSNSVSPSRPSPAALLPESPPRDLVISDGYLHVNDLDCPRTLSFRDMNIPVYTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS47</accession>
    <name>A0A9D4PS47_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029439"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="358" mass="39148" checksum="13FC38F887792CA3" modified="2023-05-03" version="1">MKNYSFPEEGVGRVDTSVTGVNFMSNDFSMAYRGSWEAMETAMQGYDNCLAAMRHDGYSYDPCAFAYRGCSPTTNEFISDAETNFVQPTSTTYHSSDAAVAPSSPIVASEQHQQQAMTQQQSTNSSACVSSKSGPVHQGPVLARDWHPASVTASEQQQLQRHVNTHLSSGGQYQVAGYAGTKEGSAPYSLNCGVSSPPAHSTNHCGPTPVYQWMLEHRSKPVTGTEVCTLSPTEQGGGEDQGFKRPRTVYTREQLLLLEAEFHYNKYLCQTRRAEMAAALNLSEQQIKVWFQNRRMKLKKQSRRGFPASPPGDSTDDDSQSCGASESSQGTPGSPKSTPESLWSTPEPLINSLLQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSL8</accession>
    <name>A0A9D4PSL8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_023271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039364"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039754587" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="25"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7952422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="574" mass="63291" checksum="AA27DE3063D89F55" modified="2023-05-03" version="1">MNAASVSAVFSAMLVSALALLPENAPIVRTECGLVTGQTLTVSGQKVDAFYGVPYAEPPVQELRFRKPVPARPWNGTFRATSKPPPCAQTNHFHTDNVTLYYGLFNSEDCLYLNVWRPTKPCKDTVSCKANLPVIVFIHGGAFQWGDSAIFLHDGANFVALSNVVFVSFNYRLNVFGFLSADTGELPGNWGLWDQNLLLKWVQRNIAFFGGDPKQVTLLGQSAGAISAAIHAVSPYGEGLFKRMIMLSGSPINVVFTVAAKGVDIVMSLARHVKCVGWRPRELADVMDCLRSVDKEDFLRLLNGVDPRKTIYAPVSGDAYVPNDCSFLSTWRNKIRSTEVMVGTMKDEGSLFMDIAFRLAPFVRSYIDIDHRTTATAIISALLKISGGSAKVVTEAYFPDDHPGDKEAVLRTLQEAAGEGLFVCASNFFAEVAADQGLPVYRYVFAHRPSYSLWPRWYGATHGDDMPFVLGSLPFYGDPSRKPTVPLSNDSWPLYTSANPEYVSVELNGPTKRLGPSRDICNVWRRFLIKNRGGQRPLEYPGRETSRTVMTTLCVLASLKIRISVTPAEADEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSM0</accession>
    <name>A0A9D4PSM0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_020968</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSM0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046630"/>
    <dbReference type="OMA" id="FWAVFCM"/>
    <dbReference type="OrthoDB" id="6434107at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="13" id="KW-1053">Target membrane</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="17">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7952262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="732" mass="83885" checksum="DE1D205E2AB4425B" modified="2023-05-03" version="1">MPPRAPQRLLHALAGVTDTEDEVHIVASSKSLAQQSGEHFLYPALLPELEPDEVRYFELVEAADITNLQAFLASHASLNKDCVNCQGYTALHVAVRRKDLSMVKFLVQNGVRLNDVLLHAVETGDVPLTEFLVAELSKTDPQCEKRGYPHSATYTADVSPIILAAQMGHWTLIHFFVKRGLEVEAPHTASCLCKTCIKVMRVEGVNASTRNLNTYKAICNPHYMLQVSGDPILDSFLYAQGMAGTSHAEEEFRREYDQEIAKLRTFTCALLDQCRTVEETRVLLERPAGLEGRVAHLAFPRVILALQYNEREFVTHGHVQQVLRIEWEGEFKAWNRLAFPVKLVHFLIRFFTLPVVVIWVKLMPQSVMAKHWSSPVNKYMNHFAARLMFVFFVYMQICLDKARASRGAPHTGVEWLIVIWVMGFVFEEIVHCYTIGASRYFSSMWHWYDITMISLFLLTFIFWIVAWAELLGDPSRGTVPPRKDWPSMDSTLIHEALFAVSSVMSVFKLMFYFQESAKLGPLQVSISSMMIEIVRFFFICICIMLAFAFGLTRMYEPYKGMKRTEPDGEEVKQSPAFTSFGNSMKTLFLRMLGVASDDQADVVVANAEDGSINEHRFTEVVGSTMYSVYQVLMLIAMLNSLIAIVTGTFQKIIDNAEVHWKFYRTRLWMHYINEALVAPSPFLFFQMPLLIMDLVKKRRYWPLRNQPVDSYSDVVNKVVQRYLCHERVILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSP7</accession>
    <name>A0A9D4PSP7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSP7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16734" checksum="298BD3142DB40D29" modified="2023-05-03" version="1">MFRSDRCIARDTLSIRSAPLPQSAGEEAEPEDTVEDPPSHLVDHDYLGAPQPAMRPRQSRNPPPLHPGRQTPVRQMHATAAELAEDQRRLLALQEQMLLQNAHQWEAVREHLSAIEAAQRRQADALVEIATVLRDAFGGGQQPRRTQGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTC7</accession>
    <name>A0A9D4PTC7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_008080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTC7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040757"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039236441" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14988" checksum="C7D6E46E5880449F" modified="2023-05-03" version="1">MDSVRRLFMIALIVGLALTEAAEAKKDKRDEEEQDNPTDQTVKNECWLKPNYRRCKDYVPRWFYDTTYLLCKPYLYGGCGGKNANAFRSHDECMRRCMFEASPSGSLFKWENLHDCYIRRCFLGDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTT4</accession>
    <name>A0A9D4PTT4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056538"/>
    <dbReference type="OMA" id="GRGAQFM"/>
    <dbReference type="OrthoDB" id="6474427at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7955644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="316" mass="36712" checksum="FB75E7DA9590CF6B" modified="2023-05-03" version="1">MAPRKPYCQMIDGVPRCPGLEPELFRESLKFRAKKGDLIQCTYPKAGTHWVMYIIELILKGGEAVPNHAEFIRYVRFIGRMETEGWESPLPIRLFTTHEPLAKETMNPEAKYVYVARNPWDTCVSFYHMATSLSMFNFRDGTFDEFFDAFLRGDFGYGDYFDHVASGYALRNEPNLLFLTYEDLKKNTREVALKLAYFLGDHYGKRLERDEGLLQSLLERTTAEYMQSVLVLDVQGVDPVWKTRRTETTVPDKSAYEGDLRKYRLVRKGKPGDWKSYFSPEQLRRLEAKVGERGRGAQFMELWKDIRDETIAASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUR7</accession>
    <name>A0A9D4PUR7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_005380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUR7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042680"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7955992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="30673" checksum="92B5FDE0E99624F5" modified="2023-05-03" version="1">MAPAAPSAFISDSASGSGVVLTSAVPVTGSPPSAIVQMESLLASGDVAGAQDAVSTSWTQEVDSTTPGFDDRSLASGAKRRTSAESLSLSNSSDGAPTCRICFFGDAKQPLLEPCNCRGTIGYVHRECLERWIQRTVDPQCQVCHFHYTVRKQAEPAWRLLTDVESRRPVLGYLVLGALFVLGIAFVFPLAWLYAVCLPTRIGDKLAATVVVLLTVQNMLWLYFPFVSFMYSYKAYKKWHKGSTCLKLVLSTDETSGPAWSNLRFWRAGGGSRDPVLSYGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUW1</accession>
    <name>A0A9D4PUW1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUW1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10395" checksum="AC32884641790C18" modified="2023-05-03" version="1">MLPTVLTILRRSSVTVLPFFALLLTAPLKLTAAQTLYEFYAVIPYKTAGDVYCSTYAADSYEYPTWAEYFGGGCEGRQCKYSSAGDMLVHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV61</accession>
    <name>A0A9D4PV61_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_007326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV61"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046356"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000066">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7956217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38940" checksum="8140B69FA2BAE24E" modified="2023-05-03" version="1">MAAVLTLNPKAEIARHAQALAVNINAAKGLQNVLRTNLGPTGTMKMLVSGAGDIKITKDGNVLLHEMQIQLPTANLIARASTAQNDITGDGTTSTVLIIGELLKQADIYVAEHLTEVCVDAVLAIQRPGEELNLHMVEIMEMQHKTEMDTQLVRGLVMDHGARHPDMKKLVRDAFVLACNVSLEYEKTEVNAGFFYKSAEEREKLAQAERQFIENRVHKIIELKRKVCDTPEKNFVVINQQGIDPMSLDLLAKEGIVALRRAKRRNMERLGVICLSCVVPGAGAFELAAHAALTAMRPTIEGKAQLGVQAYADALLIIIKTLASNSGLDPQDVLVRLQKEQQQAQQPIGLNLRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV92</accession>
    <name>A0A9D4PV92_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV92"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047124"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="387" mass="43313" checksum="89DD5122F178B5DB" modified="2023-05-03" version="1">MYSVEAQLRGLSKVNDHLPEQPLNRNVKHTVGGGTPEKPHAEESRLLPRPYWAPISGAPLTFDTTADLEAFLAQLGQLLCKELRHRHYNTLGNLLRFYKDYREGSTTSLATFLRNYPAEVFEEGLSCVGLSLHLCHAMEQQFPYAQPFLVSCEEWIPDVASYCSHDPPDDASSVKEHVLVALRVLAGTRRGLVLLDPGYHVGFPVVVMDDGCAPHTGHFVQSHTAKSTKEYCYEALGEGYVLWRVTETRMGSSKTWDNVLYVGGAFQSALSYSEKRNLLYDFRTLVARSNGHGPTAGVYCKLDELNRNPVFTLFYNKDGRRTEAKLPFGSFGSATPPAVTECAQQIDMAPDKLLSLLTGMADLYEDVDFVNQLLDLNRRVDPFEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWP2</accession>
    <name>A0A9D4PWP2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWP2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028171"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="180" mass="19847" checksum="A07DBC6B41B5C1C9" modified="2023-05-03" version="1">MWHGGKLWQRNYGNESYGNEQEGNDLTPPTPALQEDFPALETESDTDTQDTEAHAESQDAGDLPPPSEKVSPTPCAPAETSDSSPDAYEDHSASKAEAPVSVPSRDHESSSSEAPKNFDGTRHSSNGTCRSPDHRPRQDQDRDYASDGDEHPSQQILCSDPQTEPVQPTLQDHRFGRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYI0</accession>
    <name>A0A9D4PYI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TGF-beta propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051584"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta propeptide" evidence="7">
        <location>
            <begin position="80"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="471" mass="52362" checksum="A7E5140953829B1F" modified="2023-05-03" version="1">MPRRGWLRYNTTGWLRAKNRWKGAPLDVRVAHLLLKSLAAAVASILVEAAAPDWTCPVDPVYCLQPPASVMCCGVGTETEVKKQQQLMLIRAQILHRLGIRNPPANGSLSAPLNNSTLRLVEEIVRSPPPSVQDITTARTIYSERIQSFYPSCLTPNQTDPSAWNRPDHFRLHYDVSFPRSSPGTEVSLVSAKLRLYRTGAAITGGPSGTAAAHNLLDAPAAPVTVSVFQFLRPLKTGRLEKKELIVSRTLSSGRRGWEEFNVESAVSRWHRLRNKNYGLDIEVVDARGKKLLPGRYFRNMSCAQTEAGQQESPFPNIMRLHPGLRDNESSLLDNETYPTLDLQVVEVLRHDSGAVGPGSDSPQFVGADHAARPHRRRRRKVQDAAMVDGDHRTHSACAPRQIDVTFAGEAQGHSSKKDDRVHQRPCVRAVSSCNWAKYVPLNLTYLDEDSVMTTTIENLVASDCRCSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZC1</accession>
    <name>A0A9D4PZC1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011194</name>
        <name evidence="5" type="ORF">HPB52_013751</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZC1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054662"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15604" checksum="0786EF108C906EDE" modified="2023-05-03" version="1">MQWRPPLITLHKEKSYENCFLINNSPVFDAEEARLNHSDHLQRVTLRLRSAERCKEAYPTANMQDQVCATAKDGQPHLDDFGAPLLLTTDDWYVIGVFSWFRLRDFPTSPFVFASTAHHIQWIQSVIGKSSGAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZR7</accession>
    <name>A0A9D4PZR7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_013007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZR7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026847"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7961877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="559" mass="62581" checksum="3B54F2C4377A11CD" modified="2023-05-03" version="1">MILFGRRSSRVVLHKKLVPIGICCGILLSLTAVPFMGCQRRKSPPSAKDGFLLWQSAPVDDEDFEPVLRLDGRSKTSQANSPEKVALKRPRFYSTELEIREKLLVVVLTSPETVEPFGAAVNRTLSRHPNKIIFYSCASDGESSATALGAPSVLQLPGTKCDSLASHVLKHLGGKNTAKDFDFVFLMRDSTYVNGEKLVSIATHVSVNVEVFLGRPANGACDLDAGLLLSNGVFKKVLGNIDSCLAEKGEILDDHIAQCIANVSGIPCSDIFQDQPFYSLNLDKDLGYIPDPATLTTRKDFSAVVTLYPVLTSKYFYPGVPDVFGNIRSFAVSSSNRFRRSNAKLATISIRIPEDRRVPSDFALIDLVVRKLPQDSLILLCQTGMEIRADYLNRVRMNTVSGVQVFLPVPFTQYHPVITEQDPVAPAFLELKRENGFFDSNNFKHFSFYVSDYWRHRALIAKEVPLAHSSTDLTADHYHDLTFGIVELFLVSKQLHLLRAVEPELRVRYIWRDCSDEPNLRAAENLDYADRAGKSNWAYDLYEASITSRLQLRDCKYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q021</accession>
    <name>A0A9D4Q021_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q021"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16421" checksum="B5A791F4F27EA145" modified="2023-05-03" version="1">MSSKPTNEAARLFREHEISSTTGKLFSTRTGERPFSGSIAGPSEDDQSIETALEPTPTYEDYITAVEDHGPSPGEPEPSPRLGCRDEAMGADEGSSRVMPTMPPSWDTSYPRDTCSLYRPSWNVFWQARISMHARLVVPERERGTRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0D9</accession>
    <name>A0A9D4Q0D9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_014666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0D9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038239"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038945"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043339"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="603"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7962164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="76734" checksum="790FD304D305BF37" modified="2023-05-03" version="1">MDTIVVFAASLMGTTNVATKSSLVSRFTIWDYLVFCGMLLVSAGIGVYYAFFGSKKVSTDEFLMGGRQLSAFPVALSILASFMSAITLLGTASEVYLAGTQYVLICVSYCFVIPTTAYFYMPIFHHLQLTSAYEYLEIRFNQVIRSMGSITFSIQMLIYMSIVLYAPALALSQVTGISTWTSILSLGIVCTFYTSIGGMKAVVWTDVFQITLMFGSMIVVVLRGTIDLGGLGYVFDKAQEGGRLEFFNTNLNPAERHTIFGVTIGTYFTWMSVYAVSQAMVQRYLTIPTIQGARTAIWLNLPGLSFLMLICAMAGLVMYARYYDCDPIMTKKVSSADQLLPLYVMDVLGKFTGLPGLFVSGIFSGALSTVSSGVNSLAAVTLEDVVKRYIVQDMSDRSSTTLTRLLALTFGCTAIALVYAAQNMGNVLQAALAIFGIVGGPLLGVFTLGLFFPFANSIGAGVGILTSMVVTFWIGIGAFYYKPAKRLARRSVMGCLQEYINATHQNPANVTFPVLPDPDVANKDIFYAYRISYVWYSMIACMLVVFVGIAEAYDWDRMVELGRRKKGADHVESGQFNAGYVAEQAAPSKDRIEAPAHWTIGEAPAPGTAVIPPAPASTSTMTVSVSEPAPHPQDQPLGIKPSSPAPSEPFDVTSSKAASPSGHGGAISAPREQKPESATKDPQPTNLQQAVPATAPTEDAQESSGAGRPALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q121</accession>
    <name>A0A9D4Q121_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_016926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q121"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF72">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25286" checksum="CDD3BB6C40AA9A1F" modified="2023-05-03" version="1">MREALTQNRGVTVGGLPHRTMPGARLADLNSVITCMLCNGYLVDATTLVECLHSFCKVCIVQFLNTSLLCPICDVPVHQTKPHQSIRLDRTLQDIVYKVVPGLYQKEMKKRRDYYEKHPEHVASVSCPEDRGIVDDSSRLIFSPDDNISLSLEYCGPAGKKEQEGTPPAGEKSEEKKPADSGKQAEGGVPRRFLNCPAAFTINHLQKFIRMKYSVAPQYQYFAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1W7</accession>
    <name>A0A9D4Q1W7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1W7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="90" mass="10409" checksum="C7832CEEBB846D2B" modified="2023-05-03" version="1">MPEVLSSRLTFEQMLPLEKAFQTRALFCEFRVRLLDLELPLEPDLDLELLLDDSDATQTPVSASCFERPLERERLLEGKATGEDLRHAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q215</accession>
    <name>A0A9D4Q215_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_019365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q215"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7963049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="685" mass="74719" checksum="D09032749C0CCBF9" modified="2023-05-03" version="1">MSTAMRVEVDGVEISPDQITRAQGWKTAGEKVKQGGVGSLGLTPISQASQDGAKAATDVNGRGNDLGGATGNDLRQQRTKKRINKGKLLKGARMPHLPRGDIKIVMRPRDRLRISDVTSVEISRAIMAAAQVDVIAAREDVICLNHQQNIVVVSTSKREHADRYAMVERIDIRGTSHEVSAYESAPHGTVKGVIRGIPLEDTAQEIQDLVVHRHNPTALQANRMGRTRSVVIAFEGHKVPNYVRYGNLLIECTLHRKQIDACYACGRVGHRMDVCPNPQDKICRGCGIANPGEDHKCEPKCGLCGGEHLTADRACKARFKTPYVVRRRRWERRRAEEDNEDRNQGKRGSKERPQRSASSQRGRSQTPARSSNGGGHQSRSRSKSRSGDGGGGGNRRGKRTSRGSSGRSRSRTKSLSQSRAGSRPRTGSRPRAGSKFRAESIGRRGTTAEKKVGWTDRSSVARVSETELPSLTPSQLPSPRASPEPDSNEVAELKKIIERQNAQIQEQNAQIRALMSKIDALASGSSANGGPQGGNNTEENAGGKRKTPRREPPSPPLGRAAGAARPTQQAPNNQEAMDAEESTVNRETATAMAQIPKEGELPAILAAITQINKTLSAIDARFESLEGEVRTLSVKHERLATKVVTTTVRNRFASLKKKRAEKIKESIAHRRGRIETSEEDETAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2P7</accession>
    <name>A0A9D4Q2P7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_018795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2P7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044382"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="130"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="300" mass="33003" checksum="6FBBC3A63433AA62" modified="2023-05-03" version="1">MSSPNVAVNALILVFRSRISGGTEPQGYFDNWSDSLKPLQCEGGPPNALTNKDLSGKNDFWFSWMPPDVPEIDVALKGTFVVNNEYWYDIEIGSAFPVDEFPVSMEGCGQVKSCVTLSRTRTKCEKASRCDLTVTYSLSADNRTLEVTMGGVASMAGRYLAIAFTNDSESLKSASIFACTRTERLAEVRHFTLADDKSMPMETNQVLGNTAFEQDGERVWCRFETPVRVAGFDLSVPLYQVYFWAGQIEMSPPYKTSKEPIQVGVAQHSRLTSASSRESAPVLAVLVSGLMAAILLRPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q370</accession>
    <name>A0A9D4Q370_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MIS12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_023141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q370"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044039"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="222" mass="24557" checksum="0F3A07DFDEF94371" modified="2023-05-03" version="1">MTDGSYAVQHFGVSPKSIVDCGKAVVKLVVQVVYNVWFDYTEKCLDALKAALQDKASGHIAPDELEAWVDSVFREMVPEFNKNAEKLEEYMKRNIVHVPSHVLLPEDGAHRLSADERKMSVSLLRAQFGSLRRQIVQETARQQALLGEVAQQDVLREQLRFKLQNIEEMAQRVAEENNATTGVPADSDACLHLDTSDALALCTDPEGVPGAGAKEEAAQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3F0</accession>
    <name>A0A9D4Q3F0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3F0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050158"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="670" mass="72464" checksum="BEE93741497D240C" modified="2023-05-03" version="1">MSTLQRRYGLSSWSITVILFADSASPFFVSFLVGHYSRTVSKPLLIFCAIVALVISCLMSALPFFLYGPGSPLGVVGRCRRTTLDTCQTADSMQPLQPSCEGRGMPESYVVTAVLFAANCFYGSAYSVLFISGSTYVDDSVKKKNSPLHSVNDRPYLNILSVASSEVFTSTVSTVAILRLAGPTLGYSLGSLCLRYYEDPRLDPSLERTDPRWVGAWWMGYVVLGACLAATAFLALLFPRNLSPPASRCAAREAPAENANGMSTFWRSLRTLFGNPAYVFRLIYWLLASNATLGHAMMSSKYVEVQFRTSASQASFLIGPVLMVTNALGLGMGGLALHAFRPRPRLVTLYTTLCDVAKLACLVACAFIGCEAIRLAGTISTVPGHGSSIQVACSNTCNCTTRHFQPVCDPVKDTVFFSPCHAGCTKISATESGTVSLGNCSCFPRLPAQYEYQETDQEAPYLGLCTTDACSHVMTFIALSSLIGFIVRTTTVGHTIVGLRIVPREEKAMALGVQEGLSSIFTYIPYPMLYGAIFDSACLVWEDKCGKPGVCWLYDTDRLRYAYHGLSVAILLAAIVFELGLVYHSGRMSDFYSDAPAPSSSLHKSPVVISDGPEGSPLVDEQKKTKARTKCEAAEGGSGESEDEDLLSDEDRQTSCGCCKQEPKDQASTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4N0</accession>
    <name>A0A9D4Q4N0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4N0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="10993" checksum="DB6FD7E3E2B6BACF" modified="2023-05-03" version="1">MVGQRAVRPSQNASFSNFRIFNGRLQSHWGGKARSGHTAAHRRCADWFFQFSNSGHRHNAELRQVREEGSTPAGKSAASLHNNVGRVGHIAGSCTPVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4R4</accession>
    <name>A0A9D4Q4R4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4R4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="20917" checksum="5E817F262AA3A36F" modified="2023-05-03" version="1">MCGGNDALDARAVTAALTHIVKEKALPSKDMGIRDENIEEAAVSIPEDVIEELEALREPPRKPPNSVAYSGLVYVGGYIAKVITDVGCESCAMLVTTKKTSSPLYHLLRQQEAYDLHYPKPELLSMLETIVTFFEKAVKYLPRTKILETPQLTVEPYLEDSPLLDCPEGVDKSHARTERKKFRSLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5T3</accession>
    <name>A0A9D4Q5T3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5T3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048313"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039130309" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="20787" checksum="A4E3B1A6A1ECA248" modified="2023-05-03" version="1">MRLIPLTLIAALLANVALVNGYSVYINVTSEAPTDVVQASRSDPALPFPVVLAFAAPVIALALGALKPVLLAVGLIFLTFFGLMFVPVLGEALQASLREFGSALTESLPPSLGRDMLPVVGLDTEACRTRAVCEITEEAVRKHPTVAAMLRSLTAAVQAHGNSESLLKGLLGGLSGLGCESLYPTCAQSPFDEFLEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q648</accession>
    <name>A0A9D4Q648_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_010804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q648"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048857"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7968719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="12970" checksum="C2B3F28355216275" modified="2023-05-03" version="1">MASPYHLHHQQQAPPQPPLQAQQHMGMGVGPVLGGPGLGAGPGGLGPPLLSPVQPMGGPSGFMPTGPPGPSDGSGEPGVPLQPKDFNTAIMCRMGQEIVQEIVAKAIELFQTLKALQVRHMIYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q940</accession>
    <name>A0A9D4Q940_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q940"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050915"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7971977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27566" checksum="A2BE959DF3F75B68" modified="2023-05-03" version="1">MVASTATTTTVLQWHLLHLASDPDGLQTLLQQEIAAVVGHERPPSWQDRALMPLTMATIWEMYRCKPPTPFGIPREAAEDTHFGKYFIAKGSVILPNFWLAHRNCSHWEKPYEFNPRRFLKPDSSAQVTRPNGLLAFSVGRAIGFLGTLRQGSYPIFGGTGDDDVEDWRSASEHHFCVFCQMAESTKRKRMCAGESMGNSEVFLYVTSLLQKFRILLEEGCSFDINKTGIPASEVAGIKLRFIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9B2</accession>
    <name>A0A9D4Q9B2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9B2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028100"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14335" checksum="023BE9E6192811F5" modified="2023-05-03" version="1">MASEMAGTRRRVRQAAVLTPLAAHRAALLLPRRLSCGQPPRGNPLGRQRFRRLYLVDAARMKQCCSIIMCACVLHNICNEERDFCEELRKFPDLEEVGNDEDSGVVVDRSVEGYSECLRKAIAQKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9Z6</accession>
    <name>A0A9D4Q9Z6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9Z6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041217"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945:SF1">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039038766" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10397" checksum="4D21B32CD7B21C13" modified="2023-05-03" version="1">MASIGLLAASVVPWWSEQALLVVPPVQRRSPPALDLQTALLAAMPPGDLCPSHAGVRDLCQQCAKVTKDPKAFRMCCSNTREARTWCASFLDFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAS3</accession>
    <name>A0A9D4QAS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="7">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037615"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="193"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7972846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="360" mass="39729" checksum="724B7BB8752F3739" modified="2023-05-03" version="1">MADSASVLCPTPPMTPATVVEALAPSPAAPIPPDAGIAADIPNYDPNDPVNQAWWNDTLSSLGLGTEGSGADLANNASRPAALKPLSSKRFQKICTDVVHDLNEYGICVIDKFLGRERGSMVFDEVYSLYGSGEFQHGQLVSERDDTGRIIRGDRTLWLDGTEAGFPAVGFLVRTLDAIISRCNKSQELRHYCINQRTKAMIACYPGNGTHYVKHVDNPNQDGRCITSIYYLNKNWDVQTQGGLLRMFPMGQSTSVANIDPIFDRMLFFWSDRRNPHEVLPAYSIRFAITVWYLDANERKNALRRLQKEHYVYNPVLGKALGVPQKGLLTRSAVPSLLAPSFPPQVPSQEQTSVSVSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBL6</accession>
    <name>A0A9D4QBL6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_024134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBL6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047422"/>
    <dbReference type="OMA" id="CFWSQWK"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="232"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="444"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7973326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="600" mass="64093" checksum="E6D101D27CD7C899" modified="2023-05-03" version="1">MTNEHGEIVRDPNSKQSTNVGDAVSNVTYGSANRTRVSPNGAHRNGFCNEAYEASDSSEDLSNVVDSTSTKGFVPSSVAERARPAIQRSLTVVETTMLRPPRVPQRLRTVSAGLHPEYDATRRRNSRRLRFCPRGSLYDVIQDLPVRPIIGDAEEGNVGATIREESSPVPPNKPMPEETKDEDVAETPTEILVQVFVPFMLAGLGMVAAGVLLNKAKDLDAFKQIPELMVMVPPLLGLKGNLEMTLACRMSTLANLGNAASRSALLSIAAGNLALIQCQAIVAGLVAALLAVIKSLATEGYLDWSHVLTLFTSAALTAELASIVLASVMILVIVLCQRLRMNPDNVATPVAASLGDVITLALLAGFATLLHVPLRNHQWASGLLLGAVVLLAPVWAFLAYRNTYTREVLSQGWLPVLFAIVVSSGGGYILEIASTRYKGLAAYQPVINGVGGNLVAVQASRISTYLHLTTERPSLPPGESRCVGPIAVFFGSCLHARTARLLLLLLVPGQLIFVAVIDSVEGDGEAFHGPFVALYVAAAFIQVCILLYVARVLVYALWSRGTDPDNAAIPFLTALGDLLGGGLLALVYWILDLISPSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBN7</accession>
    <name>A0A9D4QBN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039151"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="105"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="279" mass="31105" checksum="A4442A58AC876035" modified="2023-05-03" version="1">MHCTVQHHRVSVLDRARNVDVYRCGGDLKQLAEALSINIKTARSIAATDRQKSLRGGGSKKSLEMTSYSVKLVTQRPADRNRNRDSRKLYAQWLQSDGPRVCRFYLDETNYNIWCSRNFGRAAKGQPAVHTTTTTKGANLNIMACMSANGVIHWTAVDRVNWAVFNNFLSDVSARLESEEPNTEAVFIFDGAPAHARAEQAANSMHSINRLPAYSPFFNPIQKVFSKFKSHLKAYLSERPDLVLATPQGYDEKRAQAFFAAGRSSALHAADTARGLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCP4</accession>
    <name>A0A9D4QCP4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_007208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCP4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049977"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="116"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7975980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="429" mass="48459" checksum="03964256F941E262" modified="2023-05-03" version="1">MAPPAEYAAVAPPIVDALKSSAKLRANMSWLLYYAHLEDLTRDCSQNDFEVLTDVRTMLESDVSFTLFSPTVDRNQLADASDPVWHEEAVILGGFSEASAHQISITGSFTVFGMEVWLTLLGCLVVLPFVASLAPKSEYTFWFNLKNYSFRLLAIVFLESSPRTPRQVSARIVIAFWWLAMLVLTNFFSAEMKAALTVRQPSGHRVDSAADLAARDDVNAYTMHGTVYHLLLAYSPRDDDRKVASKLTPSFRVHYHRLYSPAVLDEVANGRAVIIADRTSAVYQIARACHSYPGHEFYFGRERLFSHMMVIYYGRHRERKLTNVMKKWNTRMNWLTEAGLLNKWHDDTESLAGDFSRCPKIRMGEAEQLDFEHHQPIFVLFLAGHALALAALLVEVAVNGVAAPSTTSRRPLRIPRTYVRRINNVVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE65</accession>
    <name>A0A9D4QE65_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_019062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051032"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039621800" description="Serine carboxypeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7976757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52717" checksum="729FE54132A283D2" modified="2023-05-03" version="1">MELRVLATVALAIILISRADSAEKGDDGNYESLFLTPYIKAGQIDLARKLSRVKLFEDLIGAETHSGYITTDSWKKSNLFFLHIRALRRSSLQRHVNVVYLDQPVGAGYSFTKGLLGYAKDLNDVSSGVLTFLDQFITMFPEYANRTFYVGGESYGARFAVGVSHAIHVGKEPRVPLHLRGVILGAGFLGRLMKVADSSAFLYEMSLVTKKGRKSLAESFADMRRKVRTLIGKLAALLRLRKTIFTSEKKPTLFQKLTGFNNQASALYSERPMNMVQYEKYVQSDAFKRAVHIGRDVEFMKDEGKVATSLKNDYPDRHKTHYYCRCPLIAAYVTAKQPPWSPLRLRHEIEALLQSYKVLFYTGQMDTLFPSRNLQEYFRSLDWTGAEEFRKAEPKHWKAYPTSRSVSGLVIRVRNMTDVVLFRAGHYTAVDEPDAANKMMLNFIEDNAKEWGIPDHAETSEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF66</accession>
    <name>A0A9D4QF66_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF66"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045272"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="2">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7981683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="17940" checksum="D5DEFCE012AF9AB1" modified="2023-05-03" version="1">MMKKDFLELLKEQKTLDKHSRWGDVKKSMAEDARYRAVESSSQREEWFKEYVSKLTTPVRNPDASWREAKRTLRKDHRWDLVESLEREEREKLFAEHLEQLQRKKKDKYRDLLDETPGITLSSTWKEELTPSGQYLWLPALLLEDEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFH9</accession>
    <name>A0A9D4QFH9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFH9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7976608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="808" mass="90670" checksum="1FD369583D4CBD1F" modified="2023-05-03" version="1">METSAGLKDGDVRAENEALKLELERLHRELAQTSHEKIQSAQYGLVLLDEKQALQQRCDELESMYDTTKHEMEILKEALAKVQTSQKVSTTTGIEQEESLLQETATKEASLTSSLQELEKELKQVRQELSRVLAEKERLQNENYEIMKHGDVSDWERKNLRSELKDMKLREQRLLTDNNELEEENISLQKQVSSLRSSQVEFEGAKHEVRRLKEEVESLNAQLEELGSLRRIGEQQLEEALEALQSEREQKYALRRELDQRLTAESPVFHLDGLSFAGFRLGNANPDESNRVEDEDGDSEGEGSTTCRPSTVGDLFSELHLTEIRKLEKQLEQLETEKGHLSGVLEDAQQQLEKLRSIPGGDQRLVLARLVGPIRALIALHGEEVGTDGAENGVDDVTRLQKLLDKHEQRYRKALQQIAQLQAELDGMTDGVDGEADTVMSGKLRDEIANLKNKVHDYEQIMAEIKEDLSVVSEFTDETRNRLGAAQEELLAVSEDLAQLYHHVCTVNGETPSRVVLDHAKGSRPGEEGESPAATEDAPSTEKAPSDSSPIEKLKTELFRQALLRENTVDPSQCATLSETLRDQVRHLRVAVETTMEMGRSRAPPIGDGMAGTVEEEELQEQVIKLKSLLSTKREQIATLRAVLKANKRTAEVALTNLKSKYETEKAVVSETMTKLRHELKSLKEDACDVRLAASDVRGALRRRQLAATEDERKTLNSLLRMAIHQKLALTQRLEDMEMDRERSHMRRHTGTPRRGPSQQSGSRAACSAQRLDRCGAGTAASANRSTAKRHVLLLQTRLAELAAALGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFM9</accession>
    <name>A0A9D4QFM9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFM9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036999"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="382" mass="40774" checksum="8385D9A02C67E531" modified="2023-05-03" version="1">MGGNEDIKSDGPGGPQVNNGEDIAGATEDAPSKSARESLGKSKSMPALERPSPRDNTRISHSESNFAASLKLRSIVPEEREVRRFGEVKVVRTLSQLVGSEHSFVEEDGAEGEEETGGAPKETQVGDTLSSMDFPSTIGTDTKLDAELRQPLHSAETVGEGKTEEALAVTRLQGEATVAPTTFESSVGEPQVAKVLSDAQREKKRALADEGTVYTSFSDSSTPKPEADLAKLPFQSEGAEQGAVLLVAPGTSHAEVAKSIDEEAQKPLPFKTPEETTVGSEVEDTLVERAGLAKQAELKATTRLETIEPRGDWEGPANEIPAEETAGTKQPPKRRVSTQVSESQASEWRLVEHPKAYGGEQHQALVAAGRSFANDRGKAYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIG9</accession>
    <name>A0A9D4QIG9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIG9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="13840" checksum="182DD8F743E51186" modified="2023-05-03" version="1">MSSQLPKKSATVRPGDTLESPREVSADGDDKKKHFSRKSFRGPKNGAFPEIELALTEFVREQRAAHLPVSMELMQAKARELAREKGIGLEAQAPLAVTDGGTGVLEKPKPSELQQNMIMVIVNEGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QK74</accession>
    <name>A0A9D4QK74_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QK74"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029634"/>
    <dbReference type="OrthoDB" id="6489079at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="337" mass="38543" checksum="CB41EE4AA3904891" modified="2023-05-03" version="1">MRKKRRPCSSLAPSKTGGLTAGLPDRSMQQYSINATLSGVAEQRLETLKPTHSDESLAELFALIESNPCLWKSDSKNFKNVRLKRRLWDRFAVHLQKYFPQLGPFTGDNLRYVYSIKRRQYYDELKDKTGRTETGDLEYTGRWKFFDCLSFLRVHSEHFRSAVICPLLHFEEEQLRALGEERCDMRLEEREGTVMEPDELSILPDSVWVPPKPPGVANDKPGTSDSIEHVLDSPSATPHAKKISSSTAPLNLIPILPVVTFNSTISNNNAVPHIESVQSLSPTMSGYYDECDQLGNIIANYMRRLSYQDRLEFHCHIMSCTKDFFNCCTRFNGKQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKN8</accession>
    <name>A0A9D4QKN8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKN8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16725" checksum="127D2C574395DB44" modified="2023-05-03" version="1">MLSSSTRKWGDRHPNISVRVITLTMGLSILSSVNITKHFTGTPNCIEMKASQTLGTDSIKTDLRLTALEHSIREHSPKIVTAGSKNSTMCLELSATSNKSHIKKLSSGSQKIEAIKKCIGMWRRLKVNHSEPWYSSITVPRDFLHPLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKT3</accession>
    <name>A0A9D4QKT3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AXH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKT3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051827"/>
    <dbReference type="OrthoDB" id="10000452at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043404">
        <property type="entry name" value="ATAXIN1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392">
        <property type="entry name" value="ATAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392:SF13">
        <property type="entry name" value="AXH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AXH" evidence="8">
        <location>
            <begin position="179"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7982365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="356" mass="38150" checksum="785C246FB3001C5A" modified="2023-05-03" version="1">MLSLRQPDYLSPLCGGGGSERKVRSASEGGHDWASMSGAPPVEAPPADAWFRPPDYPSFYPRIPFPLAAYGAPPPASLLASRRPYPQPEPPPLPPPPPAFQTRRRSPPSPPYRLPSGKEGSLKHRILQPPASISIVEPPASLLAGAPLSAPPVRSRAPEGPQLAVAASSSSTSTSSSSGQVPGALHYPAYFVKGSIIQLGSGLLKKVEDLRTEDFVSSANLSRDLRIDSSRVLRVAEAPSKGDGVALLSFSVGQNQVQVTVEAPVEHPFFVFNRGWSSCNPERSLQRYQLQCHRLSVGDVCISLTHRARRTGLPPRPPPAAPGADPMNPLSIREPAPRKRRWSAPDQVAPVSERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKU9</accession>
    <name>A0A9D4QKU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19369" checksum="1F5DB1FF9470535E" modified="2023-05-03" version="1">MHPQLQDLVEGKQFANLAELAKAADGLMERYWRRFQYKPPPPPTDQVARYLAFQPSVNVAGLSGARPGVTMVAAAAPLQHPSAASYWPLHPVAIQPSYHRDQLHRSPAFATRPHFPAPPQPQGYQPLDSGGVTCHRCGGVGHIARECPSGRRSGPPRCYLCNRIGHIRSQCPGNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN49</accession>
    <name>A0A9D4SN49_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN49"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038592631" evidence="3">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24493" checksum="CF0DB2991D01AABF" modified="2023-05-03" version="1">MQAMKTATVCLSLNIRAVAATQAMCGNTVRRTLLLRSLVQWYPLRLASSPYAEVVLAPPLVSPRKQGALVDPSAVYPCGSYEAYIEAKKRRQHKKKEDESESTDTSSLSGPDERERKQMPRSYFYKGLKLPSGRLVDIRYRNKYIRKWARKEARGDPCQMCCAVFMILLLVTILYVYLSNQVTPKSSTRVPAGQKSAESTVPFTETIEDADEAFTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNS9</accession>
    <name>A0A9D4SNS9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNS9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="66" mass="7309" checksum="C1DAB4DF5CC6A3A0" modified="2023-05-03" version="1">MAGQPPIPFLANLSSPCQPAPYHHAIISYIDNADREGDNFSKYTAVGVMTKYRLKLLVNCSSPDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNW8</accession>
    <name>A0A9D4SNW8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNW8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10149" checksum="505B022B4F317DC4" modified="2023-05-03" version="1">MYTPNARIPALDSRVSPSTRQGQDLVKDRVRSRNACPSSSACQCRCGGRRSHRVQDDLQIFGTTQWRRQRFRKALGGKDKGSTFGGEAAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPQ9</accession>
    <name>A0A9D4SPQ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_021840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPQ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049273"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="274"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="696"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7936394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="904" mass="102783" checksum="3EBF954A943266C2" modified="2023-05-03" version="1">MDDLFSVFDDAPKSKFLTATTVKKEDVKDEESNRDDTGAGDFVQAIIDGKRSLDNDYEEEPNKKRKTSDIWDDFDPAEYLPHVHVHSVESVEGCVHEILRSMLYRGSEIMREVGWVIFDEIHYMRDKERGVVWEETIILLPDNVRYVFLSATIPNAKQFAEWICHLHKQPCHVVYTEYRPVPLQHYIFPAGGSGLYLVVDESGNFKEDKFNEAMALLQNAGDAAKGDSALKGRKGGFKGESNCYKIVKMIMERDYAPVIVFSFSKKECEAYATQIARLDLTTFKEKKLVMEVFQNAMDSLSEEDQKLPQVEQVLPLLKRGIAVHHSGLLPILKETIEILFAEGLVKALFATETFAMGLNMPARTVLFTNARKFDGKDFRWVTSGEYIQMSGRAGRRGLDDRGIVILMVDEKMSPAAGKDIVKGLPDPINSAFHLTYNMVLNLMRVEEVNPEYILERSFFQFQNNASIPVYYQKLQKLQAELDSFKIPNEPEVAAYYKVRQQLASLSRELQAFLTKPQYCVPYLQPGRMVHINNGNDDFGWGVVVAYSKKKVVTARGQSGLKDPVVIVDVLLNVSKESAQTKLTSKLTPPKPGEKGEVQVVPLTIDNITKMSSIRLFYNQDLKSSDNRAAVLKSIKEVEERFPKGIPLVDPFEDLNIKDANMKEVVKKIEAFENRMYAHPMHSHPDLPKIYAEYEKKMKVAQEIREVKNELKKAKALLQMEELKCRKRVLRRLGYATASDVMEIKGKVACEVSSADELLVTEMIFNNMFNELNAHQATALLSCLVFQEKSNEMPNLTEELSGPLRQMQDIARRIARVTKDAKLCIDEDTYVSSFKPHLMDVIYAWSKGATFAHVCRMTDVFEGSIIRCMRRLEELLRQIIQAAKCIGNTELENKFSEDIATAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPR5</accession>
    <name>A0A9D4SPR5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPR5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14223" checksum="050C90D939CEC12D" modified="2023-05-03" version="1">MDTQRAMADLPELQRRLLERSRLLGFEPYDRPSSEQDSGSGDDGEEACAVEAPVSRPRGKTCASGSPDHDLTPPELFRWCVEQEVLRRYGVTLEASIFCVQTETPKDIEVGLVVFWQKVVGTHETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQC2</accession>
    <name>A0A9D4SQC2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_006574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQC2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046403"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7943255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="379" mass="42460" checksum="C05B5A17028DF7FC" modified="2023-05-03" version="1">MEPPERDAGDAGIELSSSRACADRADRASRQDSCAPSPPSHLHLRSRQVLLGSVQRHTNSGLSCKPFSQGKYDDLFHFPFRNEVNVSQTEKDVNATATRSLQCGVCEKVFKYRSQLRTHLFAHVGEKQYACDVCGRKFVQKSNLVIHTRTHTGERPFECSSCPAAFTRSDILKRHALTHTGERPHECSVCGRRFALKSSLASHAATHSGKKAFACHVCGRKFALRATLRRHTRTHTGEKPYTCHLCPAMFAHLNTLKVHVASHTGERPHRCDVCGMAFTAKCNLWKHKNMHSGVKRFSCQICSRKFSLKQALTKHTRTHTGERPYLCHLCPAAFALMAALKVHLLTHTGERPHRCDICGKGFTQRGHLSRHQRAHSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQM3</accession>
    <name>A0A9D4SQM3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQM3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="77" mass="8544" checksum="7E8EA86F01E9A8B9" modified="2023-05-03" version="1">MLLSDYAKSLSDPERRRYHIKVAKCGSDDPLALSDDQFTNDVGCYPSVDRADINSLRATNPSRLTIMSQAASWSHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRG8</accession>
    <name>A0A9D4SRG8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRG8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26113" checksum="0ADD2E44F0EF3DF7" modified="2023-05-03" version="1">MVTDPAKKPYDRIREHLMSSRHKKFKTASKKAETAGTSQQTLFDMSCRQRAKETEADGVIHDFVRALAYSGIGMHQADGPLGDFARKYCKAAKTMPTGQRLRLKYLKEAFDKDMEKIRDDMRDVKVSVIVDESPDITGVPTINTLLCYYSQKNVKKHVVLVDVDRVNASNSYTVASAVSKALLTVGKTWKDVVAVATDSAEYMRKMVRETCQAEGIQILHVKDIAHLIHMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRZ2</accession>
    <name>A0A9D4SRZ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRZ2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="13720" checksum="7F492AE72ED216B3" modified="2023-05-03" version="1">MLSARNRTAGQATLRDAVLATPPQVVVGRHQHGRPRSLAGTWIAGVRRFGPLSCVSRCFGSSPATKHLATYPSQVAQSWNTTSMDPHRSSADWLASSTELAPNCTRLAPHLRRRRHIFVPFITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST95</accession>
    <name>A0A9D4ST95_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST95"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038748"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049929"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="303" mass="32554" checksum="06F5EE2E0527CA3A" modified="2023-05-03" version="1">MCSTQDPTPLVEDLTSLLHFHEAGRSADPPPANDLLDLSSLLSGGGLSSSELLVGRNFEELDGDVGGRLGGGFHEEFFKKSSGDGVRQDAGGTPRTPMAAPGGGSHTLPRAAEHAAPAAAATSTLGSVASRLAGLEGCLAALGRSQSRELQEIKGELSAIRRLLISVLFHVLPEEARSDAVAKYTMHGRKGKERFRDLQLWKVLFDDDLATCELRTIDEIVNEVAPSHPEMVSSDDDDDCSASEQPPSTAEIMHALDIMRCSVASERVRESTSAQLFTFQASLMVDLAKKKVQKDIRDLFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU48</accession>
    <name>A0A9D4SU48_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCCIP homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU48"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036254"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="288" mass="32522" checksum="55A51752F5B177E7" modified="2023-05-03" version="1">MAMSKRQKRLGEDEESDGSNESQNEDTDSEQDDLVDTEVNVDFEARTPDDSDFHGIKRLLQQLFLKARVNLSDLTNLILERNFVASVIKQCDDDVEDDDDDEAMQEDEDGVFGVMSVVNVTESRQRECVQQIVTLLRDHCRASASGLAAKFDEYFTEDGYQIGLVISERFVNIPPRIALPLYDALARDVEAAKAAGKKYDFTHLLVICKQYKASENDEGGAVFANAEEELFEEEADLQFEYNVTPDTGTAVGGDWKEEDEEMKQIRKVLVIPTTKWARIMDKLKGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUP4</accession>
    <name>A0A9D4SUP4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_010079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUP4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029460"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="244"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="341" mass="38020" checksum="B4024FD084296F3D" modified="2023-05-03" version="1">MFFSRFDGDLAGWTGERICLAGDSAGGNLCLALSLKMIQLQLRRPDAMFCAYTPVMLNAHPSPSKVLTCMDPLIPLEFLLTCVHAYVGVEPHDTRQQDARDTQAIHIAAEALSLVSNQEREPETESPHSKASVPSEEPRKEQPYPRRVDELKSQNDLHQDCTDRASLPATNGIEVNAGEEHVIFEIPADLSTSLRRKAAEMSKQSLEKVSGPASRKRLPKTRREALPWFHPENPSRLKTLEALVARAEDPLMTPYLASDDLLRNMPPAYFLCLHLDPTLDDMIMFAKKLRALGCQITIRVLDDLPHGFLNLFPRGNEALEGIRCCVTMLRAALQMETLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUX1</accession>
    <name>A0A9D4SUX1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUX1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8454" checksum="D4CA11399075B97E" modified="2023-05-03" version="1">MIRSEAKSEAKSKAKSGDRKAPQKRRGSAGGDAGRCGWDALRLGLDEGAARRESGVGRIAVSDVSAFVHRRLEREQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV81</accession>
    <name>A0A9D4SV81_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV81"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032017"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7952073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="611" mass="67763" checksum="A4B83009EC83B6D8" modified="2023-05-03" version="1">MQCVVEGHTISEEEWSDDSWQSPGYRAQERRRRELQNQGKPDLQLSASDNARAAVPERQHQIKPRPPPLRRRAPLPRLPQDTIHIVGRPRTPIDLTKVPPWQLHDALLKAASLPDQPPASRDRLRTHPTNNTFTLSVIDSQRAQAYLRVKTINVGTDTIELHVYAPPPDDAVRGIMFHAYDDFSDNEILADLQASNPDMPIVSGRRMGQTRHIVVALTTKTLPKWIFYHGTDIRLYPFYNRVEACFNCRKVGHRTDVCPLPRKQRCRRCGEEHPPPGEGEKPKCTSRCIVCCGAHNTGSSNCKYRFVKKAPPTPQWKQEAQEPTSNTQGNPSHSGPSSSRSPSPRDHSPSFPPPETSSSQHKGPERRSRSQTRRVRSRSAQRRHSKSRSRSQRPTSHSARRTPSTSRSSSRRPGEAPKSLAWQRGPPASLLSSDAQVRELAKENSALKAQISAQQSQIAKLTSYIKSLEAKIDRALNFNKQTATPTPSQTQETHPNSLTTNNTASAPAPQPPDANKRKAATPTASLHAEVDITATVTMAGTAAISTLRSDLTAQLETRFNAIHQIILETNNSFAVLKSSTEAALADFSVQLAIHHTPSNSRQPPATAPITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVB0</accession>
    <name>A0A9D4SVB0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_000239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVB0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044025"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7950751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38739" checksum="F9ABA92FEFDF8AF1" modified="2023-05-03" version="1">MSRARSPERQLPYFKKEFFFEVLAELVPLVPLVNRERKHLQQRNISFRLEPQHVDAIRSSSTDNAGSIREFNMRVHLRFCLLDRNSEQDDKYPHILTVKVNGESLALPASIPRKVPGGATEWVDLPINIVAFCSLDPYALNKVCVTWWPVRGLNYVVGLFLVKKLSAVTILSGLRKLRAAVTRATIKKKAKRRATISDDVAITRFRVSLTCPLSRTRMKVPYRAQSCNHLDCFDGSNYLQVNERRPTWTCPVCGMQAPLSSLVVDQLFADILANVPGDCVGVVLHEDGSWAPSSASQRDDAATTAATPSSSTARSSTPTLKSSSGEQVGRSCKQPRLEVIDLTNSSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWF1</accession>
    <name>A0A9D4SWF1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051950"/>
    <dbReference type="OMA" id="MMARSKP"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13450" checksum="613A7E5BD4D7E056" modified="2023-05-03" version="1">MMARSKPGANRWVEKDAWVMLMRSPSDSMFCRSACLIYWTPEQLECRSVTGVLSNKHRSLGQTQARPAMTPEKLNVLKAVFHVYMGENTPADVADKRVKSVRRHLAQKSGDVQRKYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWQ4</accession>
    <name>A0A9D4SWQ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_021439</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025998"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058295"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1328"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="18">
        <location>
            <begin position="1380"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="552"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7952300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1526" mass="168998" checksum="CFDDFD9C91465275" modified="2023-05-03" version="1">MIADILGTLVVLAYYVAIAYVGLHMSTIESDEDEPDDQQHGQTAAEEPEEKENKDSMLGLFLANRSLPLSLGFTSMTATWVGAGYINGTAEAVFNDGLVWCQAPLGYALSLVIGGLFFAGRMHATKAFTMLDPFQKHYGCWIGILLCVPAVSGEVFWTASNLSALGETLYAVTHLNITLIIVVSTCVILLYTSKGGLASVLYTDVFQLCSTVMGLWCCVPFIARYGAEAKISEAQKDWVGVIGNNDLSRIIDQLLMAIFGGIPWQVYFQRVLSADSAFTAKMLSFLSAVGCVFLSLPPVIVGASGKSANFTAAGYPGPYNLEMAHRKDIMPYAIRYLTPGVISILGQLAITAAVMSSVDSSMLSASSLITRNVYQLMFRPMATEEELCAALRCTLWVVGLLSMAMALNVQSVFALWVLSSDLVYVLLFPQFIVLFFMPSKINAYGAVAGFAIGLITRALCGEPQIGIPVMLRLPLYDEQRGQQFPFRTLCMLLSLACVLGGSAFAAYLFRSGRLEAQQDVWGCFQEPSNVAAQTARSGFSTNAPSNVAAGHSLSAAASAQAAGTRPHGGGQEVTDRESTGEQRREHADRSSGLSRAASDDKEKSTSQAAHTSHRHQRKLSGALAEQDFILEGPRNRRIQSSDPESKPSGSHGVESSKVVRRKELGASEAEPKGARMPVRRQSVQGEHRARMQGRRQSVVGDEDRVLTANDKQSAAVGAAPMKSERPLAHHDAGSSGSKRHSDRDLKESGHSAKSTTTPSGKNKERKDGTTPSKTSSRGGELPCPDGRECPQELLPLPHCNASLQEDGRVRALCKILIKAAPQLFFIPSDPEVMTMDEHLVSDALSDDEELAVLSLTRVVIKKWDDFPLSLESNYDVFVVNASSLLEQLALYSFMFFVRQLELSMTFQKPLKLAVANCSKAREHDETRCDVYGFKGRFVSNDSLPAMFDKIPDIVLTLVLIFRWNVEDAVTSEINITLSERVKSIPSAVEIIAPFRVARLVLYRCNFKHIRNKEDIPQMRYLKQLDFVHVPIAGVHVDAFDLIPDIESISLVGTNLAFIPEGVYKLKKLRRLNMAATVTSPNGTFRFCPGICMQASSLKELIFAGTAVEDLRDGIFCAFPNLQFLDLSGCSIKQLYGSPFQCLQNLRELDMQSNQIATISEEAYSGLNRLEILNLRHNCISTVSGAAIFRDLSSLESLDLSFNKIKYIEHFSADAASVRFLDLSHNSISKWSPPFFSAMRGLRTLLLSSNLIYTIDSDAVRDIRHVKTINISANPWDCGSCLLNNLHNLLNSSARLSANYVVCKEPERYVGLRAIDVEWNVGVCGPIDFYTVVWVPLLFTTLATTVISYGLYTKRWYMMYALLYLRAKIKNYKRQSHCGRFMWDAFLCYHASDAAWTRNVLLAKLESPPMRYRVCVAERDFIPGIPITENICRCISQSRVSLFVLSSEFCRSRWCMFEMMLAQHRLFESERDEHIVFIKKGLIDESQMSPMLSYLTTSRTYIDVPQSESDERLQDIFWLQLQVALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXL5</accession>
    <name>A0A9D4SXL5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_004078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXL5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7955834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="566" mass="61650" checksum="8F3CA825167E34CC" modified="2023-05-03" version="1">MSMQVTVEGEDISPEECMQSGWTTAISKRKTQGTPAQGGQTHSSQRGGGIGGARTPAGVKKRIIAASRLPPLPRENYRIIVRPRGGLNVKNVSQIKVAHALASAAQLAPAEIANDIVCSNVMQNIFVVSTPEEKNARAYSKVELITVGGANYEVGSYLAAPDNTCKGVVKGVDLDFSEEEVTDMIVHPRNPTALEVKRIRNTTTVVVLFDGLKVPNYVVCGPSMLRCTLYRRQTDVCYACGRLGHRADVCPTPENTICRGCGIESPTEDHVCTPECALCGGPHPTADKSCKQRFHMPYIVRRRRRERQKVKSPASPIRERAQSRSSSRGRSEMPRSRSKSRSSSRGRSRSKGPPTVRIHEPPAPGPTEWADRVKGTASRVRRASSPPPEHSAARLLQLERENASLRNALEQLRAEMDEMKRAGQGQPVQRPLPPVTERAETPIETLMEIPAETPAPRRPAKKRALSQPILDEGIDELRAELRGFQSELRDALKALSEAVSAMNARVDSVESKMTITDQLSGSVVRTASPSVGSSTARAFQNSPQLASDHGVSDDRLIDGRNHGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY05</accession>
    <name>A0A9D4SY05_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY05"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="18387" checksum="EAFE45378ED15319" modified="2023-05-03" version="1">MGKSKSILKTFSQGPVSRIESSMGESTCTRHTERDQKPAQTAEPLDTDMMCARNRRNRNVQGTVKITGKIESSLQHLTGTGRCKAKQRQITTKPPARREPTGRQQLHQERFPRWHPSAPSKTPEELTWAELKSLDFWDFRQNESPVNQTPGTRSSPAFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZD2</accession>
    <name>A0A9D4SZD2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZD2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050375"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9581" checksum="E02BCF9A3E40D949" modified="2023-05-03" version="1">MRALSVWLSPLFERANDSIGIAFFVARVKLAGVVVYMAYGVWHSSERQSDDPECSLLENVMCDDVSSDDVLPLAEQRREVLVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZL3</accession>
    <name>A0A9D4SZL3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_016451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZL3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038230"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7962489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30744" checksum="BA354A2877D31AC3" modified="2023-05-03" version="1">MTASPLDSNVMEDAFGNLSCSIVNGGDVDNISDVATTGSDDILGPRYHKRVRIVIIIVMIVASVVGNTIVFWKLVFKRRHRRVSKARVLFLNLAIADLLVACITMTSQVVWEVMGRVWIAGDAFCRFFKFLQTFALVSSTYMLVTIAVDRHIAIATPLAPSPDPWKLAAVTWLASCMPSLPNVYVFHSVEVAPGKCFCASIFYDRGTPLYHRQIYMGFVFFMVFVAPLLLLMTFYTGILWTIWKHSSRSGKMGQQTSSSLPRAKVSSHTGVRQAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZT4</accession>
    <name>A0A9D4SZT4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053584"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="414" mass="47287" checksum="AAA4A8D0FBBD9ADF" modified="2023-05-03" version="1">MFDCCYRGLRGKESSDNVAPKRTFLMSGTGSKPSIGQLSAAMVEHPTPEESEERHQRNFVIRAMRPEELEAAYKIRLQTNYVFSKNTLETSWKMQPDSFLVAVSDDGEVFGTISMVKYSEDVVFLGLLVVREDMRHRRIGTELLKAGLEMAGTKNKFMRCILPLEPLFNRMNLFMVRSTVLLGRNEPVKVDPSKMTVADTRGVSIKPFEKALWDRLRKYDDVLMTVDRSQMLQAFMEEEGTLTDVALREDGSVAGYSVVQLMSDGSWYFYMLAADTQDLARMLIGNFLHRCPMANDKGVVLVSPLWPTEEESFLVRTLGWSVAKRSVCRFSDSELKFDYNEVLGSLSWRQFADDLIILDQLTVDRDRHGEGIGPELTAAFVDLLSPQNIMVRLPENIEQHFVLEMPPFPYRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1L4</accession>
    <name>A0A9D4T1L4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1L4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037811"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF93">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13160" checksum="BA2121F514546F16" modified="2023-05-03" version="1">MLVHVLEGPFTQQLWSLRLADDLIAQGKSNHFDFVFIDADKSPIEEYYEKGLQLVRRHGIIAVDNVFWQGRAFNAEYDDSVTESVRRLSRKMASDDRVEISMLTVSDGVTLALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1M0</accession>
    <name>A0A9D4T1M0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028314"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49000" checksum="D1EE03E646A80D3F" modified="2023-05-03" version="1">MMDTQRQDLDNMDFQDSAAHSFPTPSGPSDQNAGIDSQHQADGAWQTVLTLRKKKALAKEKKAKSVDFSGTLNHQQASTGEATGKPKHKPTYRRLPPLPKDDFKIVVRPHQGLPVKNLTSPLLADAVIAACGGQISGDQFLLRIKPGSNIFIVSTPHQTVADHVRRLTTLSINGRPHSVNAYVATSEGTTKGVIHGLDPHTTPEALKANLRVRTQGVEILQACMFRNTKTAVITFFGGITPRYVYYNGGELPCYSYKVTTQVCKVCHQVGHRLDVCPQPDTPVCHVCGQRDPVAGHDCTPKCAACGEGHLTGDRSCRKRLKPQRNRTPKGSAHQPAQNDTSMKPPQRLRVLCNVLHKRIPVIVSNLCCCLVCGAALCFPYIMETAPGLALAGILYGKPSTSEPDAVKDADIVRSRSTEGIYPCSPCVVQRLNKNCETPQNCEDHHSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T402</accession>
    <name>A0A9D4T402_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T402"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18223" checksum="ABF7456494BEEB18" modified="2023-05-03" version="1">MDDGNGKRKRKTITIEQKAAMLKAVESGVKKKKVAQDFGVALNNKEAVTGARRIGAAANEGAAGDQDLASWDALVDAGVVPDCDTFCTYVSANADAVTTEELTEAEIVRAVTRVVNDSDECVDDSPEFANPMFGAHDDGEDGLDIAAAAEKGIIRLRKTRQKSIKDFFSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4H8</accession>
    <name>A0A9D4T4H8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4H8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047750"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23515" checksum="A99E66B290193FCA" modified="2023-05-03" version="1">MRYFNMAASRMDIARRLPAFEFACHAMDVAFSEVHCLPKIPRPALRDRGNPMELYDEEQFHARYRFTKNAVRQLLAMLPLQESGDNRGQPVPPMLQLLMALRIYGAGTFQTVTGNLVRIPQSTVCRAVGKVTLTRCWCMRFPQPAGFPKVMRDFYEVAEFPGVTGCVDCTHLVPDLTKQDSLTSMKREGRLGRFQVRCLLRADLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4U1</accession>
    <name>A0A9D4T4U1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4U1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="18629" checksum="859319EB49B4A0C9" modified="2023-05-03" version="1">MLPQLLPLVEPLKRGWLQSSMLNGVASQPVMHAILLTALPNEMRHLVAASASSPQPCDDLRAAVLARHGESYRPLPGSHHEVSLLLCHSERASIPGSDHPPDEVEPVSCAIDLSAQRRVSSKSSAYGRSHVPAIRTYSPTSNVRDTALTSDSAMDTMSPATESAADVAWPAIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8C0</accession>
    <name>A0A9D4T8C0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HPB52_002577</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
            <tissue evidence="20">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8C0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048283"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7981995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="21812" checksum="8B3727BF0CFA7BEB" modified="2023-05-03" version="1">MFLLEWLGGVLGYLGLWKKSGKLLFLGLDNAGKTTLLHMLKDDRMAQHVPTLHPTSEELSIGNMRFTTFDLGGHHQARRVWKDYFPAVDAIVFLIDAHDRERFPESKAELDSLLTDEQLANCPVLILGNKIDKPGAASEDELRTYFCLYSQTTGKGKVPRSEMTARPLEMFMCSVLKRQGYGEGFRWLAQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T913</accession>
    <name>A0A9D4T913_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T913"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040485"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038416503" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14593" checksum="C66D877E8EDD5832" modified="2023-05-03" version="1">MWKATVFILVTTYIGICHSQLKPGCEKAELHACGEDYIVYSNNTRMPDPDDPEFEAICELFREQVACTFDFAQRCLQDGIPRVVALVSMEAVGDDFEAACTEGTNEHEIQWVVQRSSSNNAAIEFYSCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9C5</accession>
    <name>A0A9D4T9C5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9C5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056292"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="15448" checksum="4716CA7549D0A858" modified="2023-05-03" version="1">MKRVGWFRSFSYSPGVVPAPAAPCKGGTDPDDQTPSGSQGEPSVFTEWHVPLASRDGPGGGGGGGGGGRRQELLPPADLSPGGGGSSVPPLPSPGNKRRGTFRFASSVRISGGGDCPPSQRLFRAGEVGEEDEKCVADQGWEEKKKKRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAK2</accession>
    <name>A0A9D4TAK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microplusin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039505"/>
    <dbReference type="OMA" id="GKELCGM"/>
    <dbReference type="OrthoDB" id="10376976at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.440">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038844568" description="Microplusin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11096" checksum="F34D00BDAB6D182B" modified="2023-05-03" version="1">MKVLLLCGLVLAGAFLAEAAGGKELCGMSHEGIKDVLKCMAEHAPPQVKEKALGLIAEKGDQAAEIIKSKCESDVDFGEMVSVVFSEKVAEAIKEAYHHCKPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAS0</accession>
    <name>A0A9D4TAS0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_015677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAS0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030167"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000018">
        <property type="entry name" value="Tubulin beta chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF8">
        <property type="entry name" value="TUBULIN BETA-4B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7983944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15350" checksum="CEB462AB2E4F6A9C" modified="2023-05-03" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEASGGKYVPRAILLDLEPGTMDSVRSGPFGQLFRPDNFIFGTKAKVATAPADVVEMVTALQSVQCGVHIRMLLRGPFRLYRSCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBF6</accession>
    <name>A0A9D4TBF6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBF6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039119"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16403" checksum="41D22E66D7AAAEBC" modified="2023-05-03" version="1">MILDAAGKPAGGILTGTLTAFGSYDQCVAIEARDSPAEEPRFTGRYCTVELRPPIPKRPRYYTLHDQVQLFNNITRTKVTGEIAEKMHFFYFLVYRYGVCVPSTCQREDVETIAASLVKSAEFEVKVSNCEVKEDNAKLNGDQTAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBH1</accession>
    <name>A0A9D4TBH1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_020301</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027513"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="459"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7984398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="54045" checksum="B93406381B45EF5D" modified="2023-05-03" version="1">MRAEGYVTMLDPFQELFGGRMGGLLFIPALCGEVFWSAAILAALGATVGVIIDIDTNTSIIASACIALFYTLFGGLYSVAYTDVIQLFCIFIGLWLCIPFCMINESVGTLTYPTNDWVGSLEPKYIGQYIDFGLLLILGGIPWQVYFQRVLSCKTAFKAQLLSYVAAFGCIIMAIPAMIMGAVAKATRWNETAFTGPLPLDKEHTSLVLPMVLQYLTPGFVSFVGLGAVSAAVMSSSDSSILSAASMFARNVYKLIFRQNVIWVMRVAILFVGAMATAMALTVKSIYGLWYLSSDLVFVILFPQLVCVVYIKHHCNTYGSLGAYIIGLLLRGLGGEDIIGLPAVIRYPFYNEEDGQLFPFRTLAMLTSLASILSISSLTRWLFESGTVPARFDVFHCVVNIPEDIMKVQEPHEGEMTVLNAGGLVKSYQTEMNGRVNPALNLHPEEDVEGFQVKPSAAIGADPLSPFGGGPLSTTAAQPPPPPLGDRGDALSSEDTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBI9</accession>
    <name>A0A9D4TBI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_020074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056835"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09455">
        <property type="entry name" value="LIM1_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09461">
        <property type="entry name" value="LIM3_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000069">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="327"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7984376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="382" mass="40179" checksum="368A13D42CE64419" modified="2023-05-03" version="1">MTANLAAFSADHRCRVGRQGGAKFTWPPAQAGGPAHVGGVLESNAMPSVPTYRPPPGTQRVTAAPSTPKWGAGQPLGAPPGGPFRPSSPSASPYSPVSSPASSRPPSFVSSSPSPLSGFGGGQQQPIGGVKVPPPTAPKPMSRAPPTKIGNGGPWAPVGQPAPALATGASSAPFTGPSGLSQGAGSRPAPKRGRGKLTQAIGGKIPICSSCGSPIRGPFVTALGRNWCPDHFLCSNGSCRKSLQDIGFVEEQGKLYCEHCYECYMAPICRKCGHRIKGDCLNALEQTWHPECFVCTYCKTAFGNSSFYLEDGMPYCEKDWNELFTTKCVGCGFPIEAGDRWVEALNNNYHSQCFKCTICQKNLEGQSFFAKGGRPFCKAHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD08</accession>
    <name>A0A9D4TD08_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000706">
        <property type="protein sequence ID" value="KAH7985824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD08"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35737" checksum="394248837A054205" modified="2023-05-03" version="1">MKKGSAPGPDGLPVEFYIEFWPIIDPFMSRVIRRCFHDLSLPHSFRSWVNTDVDSTTSLRKNSNDPRARNGRRGASTTRPDDATPSRTDTTAQGNAYARQHRITNARHRRRQDGPAQAKKERLENSGPQSSHLPTVYRALLAFHRRLETTCPEMDVAEAKVVDTMAALVQPLVPRHRQAIGCNDGRWYAAPLARTASWLRLTGMRRSNASSPDFLGVRSMLVFVDKVSEGHFAALLLVAGLFSLWRNRCEAVAGNCRRRALWPILVRMRREILAFLSEELFFLGEREFLPHWSCPFVGVERDRVQLIFRPTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQE2</accession>
    <name>A0A9D4YQE2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQE2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038669"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="324"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="425"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7984073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="526" mass="59376" checksum="9DB6308E8F76ECBD" modified="2023-05-03" version="1">MQWKFVGATYEITVIKNQTGKLYCNVTLPTGGGVGDENPTQIRWYKGAELIYMLTSEGRNVPIRQMTHRPSASWRDRLQVRTTRLPIWLSIDPVMLHDQGYYQCRVYYGNDVKRNVSHFLRVIEPPENVVIIFGTRPREIRLSPNQKVRQNEGEDLYLECHVIGGKPEPRIRWLESDRKDSVAHGSERVLKVPRVPRRLDNTSYTCEASNNNITEPLRTSVTVLLNLKPVNVSIRNKDTPLKAGVLAHVECESYGSRPAPQFSWWLDGKELVNNSRSVENDLSVLYFEPTIQNNGQKLTCISRNPLIRDSDCVDIWTLDVHFKPQITLLFKGVRVQFVNVTRGATVSLECRTSGNPHTGNITWLLNKQRLPRKTSPKKGVFFRDTTIVDIVNANRNHSGSYSCSGSNAVGSTTSNEVYIRVLYEPECLGAVDSYVTAVLDETVRIPCRVAADPPHVSYSWSFRSSLDETATRNLTTPRNGSGGLLFYQPKVAADFGTVYCWAQNDIGPMAKPCIFHVVLKVGVVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRQ8</accession>
    <name>A0A9D4YRQ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000443">
        <property type="protein sequence ID" value="KAH7986420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057260"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32732" checksum="DF42341D093D47EA" modified="2023-05-03" version="1">MLLALRINVLSKGYSGISLECLQQLVDAFNASCLSWVPEQGTVGASGDLAPLAHLALGLIGEGKMWSPETGWGDAQYVLESHKLKPIQLKPKEGLCLLNGTQLITSIGAEAVQRATVLSQQADVVAALTLEVLKGTTRAFESDIQKIRPHWGQSLVAKRLRALLHSDTFPSEIAESHRFCHRVQDAYTLRCCPQVHGIVHDTIDFVRGIITTEMNSATDNPGYSVSRCWDKDRVMAPDIDAATDLLKQSRVWDIVKPHMDHYFTVQEEETRMPSPTTSEISVASSSKKRKVDNHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YS57</accession>
    <name>A0A9D4YS57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000295">
        <property type="protein sequence ID" value="KAH7986753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YS57"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056439"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="450" mass="50693" checksum="62A76BB911B96F96" modified="2023-05-03" version="1">MNVRLRANEPASKLAERLRRAGGPLAVRDLDITNCFDVNVQQLVPLITECKLLQHLRCAACTIPPSDVLMLVMQRLPHLVEVEFSCLIDGTIVHAEIMYVEIGQEHNFRLLSTFLRCCPNASSLHVHLVCGEFHEAVRECHTLLEEHRQLDTFRFTSELPSPFQCDPPSALHFAVYVAVCANFTYQRSKNLRSCARLQDLAEAGVEPQTIPFQTALVAVEGQFTTEWLRAASITHDWRDVRQLCLVLFLPHLSNTFPAADGTYRDCLRLFSTQLRQLVELNVSSFHFGPGIDVTAFFEGGWMPFLQSLSAAPCGFRSVLTLKCLATYCPDFKELDVRFESRGSFCRCAGCESETLYVSGFHSFPSPAFRNGLARLTLSRVHDAACLSFLECCRPVATLRLSYCPLELDYELEKFFTVPGTHHVAVARRRGDEQVLLQAAICKPCPTSFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P8N6</accession>
    <name>A0A9D4P8N6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002075">
        <property type="protein sequence ID" value="KAH7931668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P8N6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="13621" checksum="75513893D006B6FB" modified="2023-05-03" version="1">MSVPTRAPYPGVWFIPQRQFCLPKVAHLALSSQREASTQKASRTPIESLRIDGSGGLPTYSPQTTIAPPRENYPARSGFSPANPPPRDQPGQQETTSLPSGFSAPFPEGVIVRASRQPGEAHGAWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBF1</accession>
    <name>A0A9D4PBF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042013"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="16085" checksum="1E1893AA28974CA5" modified="2023-05-03" version="1">MVETACVSTVKSLQTAFEVGVLTSGVDAEVAWAAVCEIKSEGAWTASLETEVASTCKAVMSKTGAGMTPVDESVGPGAGLGSEPEAAVAEAAERETVVHRPRSSQITGRSLQRRCGSVRSGRRRLSTAAFLAQPFFMVDHVTPYLFGRALRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBR5</accession>
    <name>A0A9D4PBR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rapamycin-insensitive companion of mTOR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036489"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="317"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="715"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="969"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7935141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150311" checksum="9D3A2234934C1D60" modified="2023-05-03" version="1">MFRQRSSRGARSLRSVADNLREILIYLVRQDGSKQRKLAYLNCLVKLSPKITPETELGLTLEDIFCCLRVLVVHEASEVRAGCLRALRHLVRDIDAARALVASHIPRLVARALDAALESRTERLQALRLVRRLVAVAPLELPAQLARSLVAVAADGAKETDDLVRACLATICELALLNPKLCVDTGGFRTLLQSVLDCHHPPLAEAMLGIIFHSINDPATRQLLSRDIDLEYLVAPFTDSHFKYAPDTPENNLGRASTAVARLSRLHALRRKSTTPSSLFLDQLLQFCSPTKQRSASQDFCEAAGKVRLHACLRKETDESALHSIRDSQVLVREYNSWDWHLVSSLLKWPSESLRALSENTHKTFIRRLVLFYKPSSRQFSLMETKRECANQVITVGCQLFEFLLEADEGRATEFIEDFLIDLCNCLHEAQLPGAAMSALLGPSRMLAMVSHAYFLFVGRLGSSSKGSRLLERLGVYQHIVTLVTLEGHDLYLKLALASMDYTKPGFARSLLSTALTTKCEEARLYATKFLRVLLRLELLDFRKWVMELLVIQLCDPNRAVMLTAASILDEACDVKENLEALIALRPVLLSFGDRGLLLHVRFLSVPSGFKYMLEAELLAHQLRKWDEVDNLRYVKIVEDAISQAVTWHQRGEDGTYGRRSSNTRLKVQDVFAPPHLYGQMVQHKEGLDYLQKHGSLERHFETVIAGDMSNEEALLRLKGSLWTVGHVGTSPEGFALVADADVLPSIVRMAQESPIYSIRGVCFYVLCLLASTGDSVEYLSGLGWDCVQHKHNEVWPVASDALRVVKTSPAPLRAHTWSISSAGSQQSEMLTASALHRRFHGSAASSLSCVDAGETPQRRTLNFVSEQAKSQAESNSGVRHSQTLPRNVTLSPRHDALVASSRRPRSSSDCRPGEARHDAEGEAPQGQVYKSPEAVAVHPSVAECRLLSVPDSSKDRSSSFGGSRDSGTETSFTEKSSSNPEVKGERSDSNESAITAATSKSRSDSCTDSTTSGVSSCDENAATTRTVQTLSPIASSTSLSTLGGNRGDGAVMPRRPRGFVGGVRTLSRSSTSTSPVSPDSPVLMYTSARDVAGYATLRAVREASSMRRRRKRVCSVGCDGTEPHGELFSPPSFAGWSLDRSGFYIGEEPYPDDTTSIRTLSMSSTASAATARSSAGRSEERFMGLCVPVDTALIFSVYDHVQPSMGGNGEDKLSEVTENVEERSDGFELHTSQECLLCHSVERVAKMKERLAGSPEKSGKNRKSGDRSAEIDYDPIAVRREMLKYIANLNSSVIMKGSEQALLTLKQKYPSAFQDVCLYSEVCLLMSRYRYRLGARTLLQELFFDLSLEKARCVISAFETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCR6</accession>
    <name>A0A9D4PCR6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050305"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="417" mass="46460" checksum="AC59CF5943D3830E" modified="2023-05-03" version="1">MDAQSLVNLGKEGACGETGPPTSLRKELARKTFRADDRCFLCDKRGHRAAECWSRTKACSPVHGHNSDKYSAGRGDRCEASCMVSGERNEEKAAGNAEYVVLRDGEKVPVVNTAVSRSVVLENIENVPIVKGFMNQRPVTVLRDTGCDTVVVRQALVPKERLTGTYRPVLFLDRTVRNLPEAVVFLDTPVFKGEVRAHCLRDSLYDVVLGNIKGAVPLDTTRVMATRTTNPSSSADIEEKTPKTPTNRCSRRHDQVTVSRVANRLRAPRREHSDSSPSAATSGTQTACAKRWQTTARPSGSSQLSTSPWPNSRPDATRYHGTANSQDETLLPLDTTPRVPQRRRPRQRSYFEERNTDRLNQSRPGYVTLRSDGTDSLSAQMDQSPSSPQPPLQPPSSQSHFQRHKTKMYKRRDNNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD15</accession>
    <name>A0A9D4PD15_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L28, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_015176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050634"/>
    <dbReference type="OMA" id="KMSNRLK"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="261" mass="30798" checksum="6DDDDC79F5786ADE" modified="2023-05-03" version="1">MSAGKKFVPIFERFPAHYRRFLEDMKRKPAPVHYKPPAEKYVRHPVTQIIMRTEERPIRVVYPKECQEGIWGGEGIVPGYAPDASGYHVKYFTPLLQQVVLYSEILDKYMRVTVTERTLILINEHYGFDLYILKTPVQDLHSQLALDLRRKMLLALARKDLYPDDPEKQKEMLDKYKEFIVSEEEADWFGLTLWKAEKKLMDYEDALPKPKPLKYQFLNDFIEELKLKEEKKKEEAAAEPQKSWVSKLNPFRRSPSSDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR4</accession>
    <name>A0A9D4PDR4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033595"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="427" mass="48493" checksum="8B41897C1A5AD1B2" modified="2023-05-03" version="1">MFAGWYNRLKEESDLKETELEQLRSRLQQSTHHQLLQEYQALQQTIEESKAKLQACKETQKKASARVKDLEEKVKDAKNIRDRELKAAEQQISKCKKKADESAKKATAKKQEVEGLNLEIQELEKSIASYSEQMKSSDAMLVELEEKLAQNEQKLAAAKEKVKEAGEEVKAQKEKLKAASREIAEKYAERAEVEKQADQLKLKIQQWEHDVNKIDREAGDAVKKEKLGQNVNSRAQNMLLKAEEKYQDLLKKKLTVRHDRDKIIDVIRELDEKKNMALKEAWKKVDKDFGSIFSTLLPGTDAKLVPPDGMDALQGLEVKVAFGGVWKESLQELSGGQRSLVALSLILSLLLFKPAPIYILDEVDAALDLSHTQNIGQMLRAHFKQSQFIVVSLKEGMFNNANVLFRTKFVNGMSTVSRTTQSIEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE06</accession>
    <name>A0A9D4PE06_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027604"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039271553" evidence="1">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="16922" checksum="24F9B6A196B0EBE6" modified="2023-05-03" version="1">MRQGFPLQSTLALVLHVLTGALLPQVAWADQKCSSLGFGGAWLNPCGYCVGGNTGLERTHGRDCRGTCGGTARRDCNGVCAGGAYVEPCSGQCVYGKHSKVYAARKEQLAQHRDCRGICLASQAATPARPTSQSYTRDSCGVCVRGAVTKDASAYKDCLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE69</accession>
    <name>A0A9D4PE69_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE69"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058121"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15322" checksum="0786C17D5AC42243" modified="2023-05-03" version="1">MSSITVFEDPPEPLTIPEPLHILSSTLKKPAPEPPIMAAAAPPIPPPGPSDARHLQSGESLNEAEASAKVIIQDRSQEPKSTDGSHGDLSSPDLGSSAGRDIRVDVNPAFQLKPSNEVTPPAFSLVPDDFNMVSEEQVLPVDIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEC3</accession>
    <name>A0A9D4PEC3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Crustacean hyperglycemic hormone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEC3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001166">
        <property type="entry name" value="Hyperglycemic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17439" checksum="9AF5DF1E24AAE1AD" modified="2023-05-03" version="1">METREFGRSQPRPLILSGIHNRIEINSAAEIGLNRFPNQQMSASFPVVPARWLAAALLVCSLVALTQPGGCAARNLHKRSFVELGCRGNFEQSYLARLERVCEECYQLYREPQVYNLCRGSCFKNENFDLCADALLLKDEMTDLRRMINYVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEF7</accession>
    <name>A0A9D4PEF7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEF7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15126" checksum="2F621D82AD443936" modified="2023-05-03" version="1">MISRRGRVEDAVPSIFAFSAPRPPPRKKPRNREPLNLVSATVPSEGGRSTTADVSDVDICSPTSVTSSIDGVVCGCACSLKISDLTEQLDSEVKKKAEEVELIKSSLYKAERALDIAAQERSQLDKREGLTCCPPESDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEM2</accession>
    <name>A0A9D4PEM2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEM2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="13751" checksum="820447B3AF3EEE70" modified="2023-05-03" version="1">MSLPEALRVFVVPGHVHQQRHLETAHVKAHRRKTARVQRLRKEIHREKKLSLPRSDSFGEEDGRLPRVWPKLLRKKRTPEPLAYADWREALRLPPVSRYVRVQQHAERARCKPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF23</accession>
    <name>A0A9D4PF23_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF23"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="113" mass="12343" checksum="492F99A42EB5A769" modified="2023-05-03" version="1">MAQSTSNTDSNENNDLRSEIQDIKSQLQTLLHALNLGTDRDQGQRPEGGERPAGGERMHQGPAEPCTSTVPDLDPAHVGDGDNATHPVALNDVHCNRTPNHFRYTRPAIQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGJ6</accession>
    <name>A0A9D4PGJ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGJ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043955"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="26536" checksum="9C6E115E76A94A86" modified="2023-05-03" version="1">MSDAKGHCNPKDVTAGNDQHTTTGMPVSASSQESSAACTNGETSKTANTSSTESALRSPLPYPGNLRPTPYVVSVSDCSLLHRRPIWFLQPLPATHFCAACNVVPTMAFALPCGDILCECCRDSITATARLQISDREDGAKPRDGVCPLDGVPFVESELVTYTGYADDVQEEVVLCANIEHGCSYRDELRRLEEHLLYDCRYSPKTCNFCKKKNIPECELLLHTLRCPLRPRRARVLRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGX2</accession>
    <name>A0A9D4PGX2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGX2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043607"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12077" checksum="37831CCEB6A2D630" modified="2023-05-03" version="1">MSELVKQGIQEASKGLQQENEEKILQEGLLRHVPIVGSLFNWWSPTSKEGGIRGRSFNITSGLVESTENIYKYHMQIQQGDGTPALANKPPPQAQVVVPAANALETKAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI56</accession>
    <name>A0A9D4PI56_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI56"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17254" checksum="13DB4E16AE70009E" modified="2023-05-03" version="1">MANTKTTIHNSDKFVNVEMQNQAYQIPEDKLHQDLIIRTLPNNAINTNSSSTSHRTTMFIIPKTTTHNTDDFVSAEMQNQTSEVDKLNVLIRKATKLAMGLPPMVSTTRLLRMGVHNTWQEVVEAQRTSQLERLRLTSTGRSVLARHTSKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIF4</accession>
    <name>A0A9D4PIF4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052419"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="646" mass="69108" checksum="0E171D3CCC8F8207" modified="2023-05-03" version="1">MPPPKEHFFNVRTPPGTSVDEVIDALEGLVGIQEIYSVQHHGGFDFQVGVNSVAAVQTLLETGGLRLGTRTVPLVPVARQVASVTCLYLPCYVPDNEVVTGLKSYGTTLRIEEARYKDRPSIRTGTRYIKMDMRLENPLPNFARVGGHRATFEYRGVRRLCRRCNQEGHFKAQCDTPHCARCGVFGHRTDTCTEPCRRCGGAHASVDCTARKSYSMAAAMDVDEFPALGTATAAGQTQRRMTTLRPAKRPKPNEDGPEPQVIPEKTLAQAAAITAPTAPAQQQEGRQTDAPTLASMRSGERQEEEGSHGHAEPNQAAAATEAERAADSGEGEKRGVHGARSASGDDEGEDNAASAVSWASVDETAAEESGHEDGQGVGKEDRPEARKGSQGERKLSLKGRTGPAASTAAHSPWWNKTGHDDVPRGREAPQPANDQSVSGSVEQEKSRKAPGEGDAPKPTEPSISSRKQPRPEPAPQHGGAAQQHSREGAQHGVQHGEAGGKTSRGEETAAAVLEAQKPAGTPSSDELEPGELVIDESAPTSPESPKRTQQQPLSMPAGVGRGRNSRSRETEAARGGTLFQSLRPSGPGAHKADGERPQRSVKKVRRDSAGRLRSRTSGSEHEEVTSKQRPSQRPAADDLDTDSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKJ4</accession>
    <name>A0A9D4PKJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKJ4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11035" checksum="274A797C77F7C5AC" modified="2023-05-03" version="1">MKNALSRSCLHKIHRSFNDQLKRLKDSGFPEPLLSTFIEVLVRDIRCPKEKSRIESKKRLEEQRSATSVPAASLPVVRPRSCQPAALSLDPIAVGTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKW5</accession>
    <name>A0A9D4PKW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028230"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="67454" checksum="1F62B9A8E6BD1BAE" modified="2023-05-03" version="1">MSTTSILKKRGPSTSTGVAENRVGFKLPTADDIDVQMAFTEANKSNVMASNYRQLINVLKSTDVDDEALVRLLKRIKNSAPLIERHNDEVLDCVLKINLLKRNVGVIEAFSQLACDMVFIHPAFLRGIVVSLLNTFMSPEATSKDTPERDEKLERLHALFRLLFKLVPTFDILRRFLHKVVISFKVGIKYFSFFVLLKKNSSTCEVRLELLQLLTHKALQIDLHCPKDEINEAELEDDDDAMEGDDIFEMEKANGADSERMQHPLADTLDQVLNQFYLHFQQHCNVKDGSDMTKLDWEKTKVLFKDFLTIFDKIVLPTHKCCHVQFLLFYLCSFRPAALAVAFLDYLWKKVQNPATSCIVRQASAFYIGSFLARAKYVPLSTVCDSLSLMCQWAHGYMASLNDGGFCQPQHDVQRHGTFYAVCQTVFYVFAFHHKGIADGAKGLQYLRELNLEALVMCPLNPLKACLPAVVKQFASIARHYQLVYCYSVIERNQRLALPTAGGDTPYGDVVLDAFFPFDPYVLKRTGKWIDPLYRKFEKSDDDEDADLDDEPEDDEDELMCKSPKSPNYVAEMFSYGASPGFKRSLSFNHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL96</accession>
    <name>A0A9D4PL96_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_003792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL96"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032021"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042675"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11440">
        <property type="entry name" value="bHLH-O_Cwo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000079">
        <property type="entry name" value="CLUMA_CG001539, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="625"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="857"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7946735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="986" mass="110008" checksum="D0F93F10E9928DE8" modified="2023-05-03" version="1">MSDAWKDMQEFKSRQTSLRERLQRRKKERQEIVQAISTEPVVSAGEDSSGALSAAINQPVGSPQPGHQTTAAQGPSTDSPAPPDVDEVERRLLRCLLDVALDLPADSRRLQSIVSRSLGRDVDHSALEDLLHKLAAQELIALGEDVTAEGTPFLQVTSTEHTRLQAFVDAQVIDRKRGFLMSTKEGDGDETREKRGQKRSAPDPIESLLSLPSAREKETKQLGEEILELLSKPTAKERSLVERFRSQGGAQVQEFCPHGTKQECSRSSSTGTACSKLHFNKIIQKHTDESLGDCSFLNTCFHMDSCKYVHYEVDSSSVPVSRPPAPAPSGSSSPPALLRGTGPTVLHPPQWIQCDLRYFDMSILGKFSVVMADPPWDIHMELPYGTMSDDEMRQLNVPSLTDDGLIFLWVTGRAMELGRECLKLWGYERCDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPKDINRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNVQPNWITLGNQVEGVRLTDPVLINEFRKLYPDGDCMKKPPEPVSMGVDMWPPDPHMSRPMMNAMVGYGDPMGMPEPGLMSLNFCALERRRPQDMLEDAEELGRKKAARDPMSHRIIEKRRRDRMNNCLADLSRLIPAVYLKKGRGRIEKTEIIEMAIKHLRHLQAHSCKDPTTCEVVQRVDSDHRLQYRLGFQECLSETARFLVDLDGAGDDMCLRLVTHLQKHFDKISGAGPCFPSGLMLSDEDTPTEPEPLLERLRNNPDRQPKQEPTAPHPDNSCSSSSSCSSVSQLREMLQNPGLSVQEVMRRSDYLLPKPMSVTPAPSEETYKFKNDIKDRFHKDAQWGTVERNSTPVEEQRRHSHTQGPLAPAPSPTRLTVSAPPPEVPPEPAGSPAPPGVAAFALHPRGAYYIPVTLDPTLIGPAFACMGDDPSPLHPVSISVHFGRQRVLGPPPWSQCPWRLRTGEPNGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM13</accession>
    <name>A0A9D4PM13_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM13"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045099"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF93">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="69936" checksum="91C624E0B05296CE" modified="2023-05-03" version="1">MATETGSSTPVASSSGLSAATSPTTFAPSHEIQEDAEEEVAEDSPGSSGRQLHQQRHPTQHFKTKQDQQQGRSDSFGRPERPSSRSDPQRPLSSAEQRIAAAIRQHYYPEGGWGWVVCVCVCLVNALSWGMQLNYGVMHAAAVQQFGEEHESEAAWLGSASLASSLFMSPMVVAWCRRKSIRVTAVVGGLVAALGCLFSSSLGWRYGLQAATGLVSLNFVLGAFYRSASLYHPHRRAIVHLKNQRRKIKEKQPCAVKPPFFDFSVLRTRTVRVVMVTAALAAAGLYTPFFCLVPLSTAEGIQGTWTLQALLGLASAGGAGVAGLLLVRHPTQCVLSRRCLCQLSLLGASLAMLSLGALNGFGGYALFAAVYGASAGGVAYALRMLVFERLRARHFGRAWGFVQWAQCLPVLVGVPVTGYINKSRQDPKAGFYFSAACTFAGATSLFFLPDGRRESIRCVHAPQQHKLPPYHNHNHSHDNPCGECQCPQHHRHPSTGDSPNKGSYERADSTDADAVVVRTPCACSRRSLLSYQRSTSWSTSLEYLDQPHGLGGGFAPDADCLDDELAEIVQQRPELLHCIADERVVVDVGSRCAKCGGMAAGPLCECAPASSRDRAVVSPKKAHASRCIHEPLVFRSTMAPIEEVTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM66</accession>
    <name>A0A9D4PM66_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U8 snoRNA-decapping enzyme</fullName>
            <ecNumber evidence="9">3.6.1.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">IDP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Inosine diphosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside diphosphate-linked moiety X motif 16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">m7GpppN-mRNA hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_009135</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>IDP + H2O = IMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35207"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="EC" id="3.6.1.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35208"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dIDP + H2O = dIMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35211"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:62286"/>
            <dbReference type="EC" id="3.6.1.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:35212"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nudix hydrolase family. NUDT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.64" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM66"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053516"/>
    <dbReference type="OrthoDB" id="5950381at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990003">
        <property type="term" value="F:IDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016077">
        <property type="term" value="P:sno(s)RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054754">
        <property type="entry name" value="NudT16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699">
        <property type="entry name" value="NUDIX T16 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699:SF1">
        <property type="entry name" value="U8 SNORNA-DECAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22327">
        <property type="entry name" value="Nudt16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="18">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7947275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24377" checksum="D2BC9D3B41CFF280" modified="2023-05-03" version="1">MAKAEPEKYPLDLNVVQSLDLNKNGLEACTLSEALAAGYKNAAHAMLWAPTDTVVLRRYRQKATILAVVRYDGYLGFPGGLVDPGESPVQAVNRELREELNADASRISPTESDHVISFRHKERRFAYHFYALRLTAEELLATERDAIGSREHGNETLGILRVPLYSMADGVGGFPVLLAQRFAGCARQQLLYTIVRLGLLDEAAARTAIAQSEAAFSCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMK5</accession>
    <name>A0A9D4PMK5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMK5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043301"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7944376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59775" checksum="2A31CE65EE13A793" modified="2023-05-03" version="1">MSSKEQLKRDPVFGVDSRRSWITATFCGALLFLALSSSRVSGVFFYRIAEAFGVSREQASWPVTLSGSVLPLAASALHSTQLPTMPTEEQLKKDPVFGLDSRQSWITAAFCGALLFLALSTISVSGVFFYGVVESFGVTREQASWPVTLSGSVLPLAGPLTGVLCSRFSCRKVLLVCSFFTGIAVSLCYFAQSTHFIVVFFGIIHGTTLSGLYVAANVLVAQHFEKRRATACSLMFTAGGLNTVVFPPLIELFYSRYGIQAAFLLYGAILMNAFPCSIALRRPPWLDKPKPVRQKKETALDTIYSSRRPAFRNSGSEDLNKQNCADCTDETHVFLEKSSVEETASSDRTSVKFVSSRYPGGSRLAKGNIVDCVKRELAPFATMSFIVSAMSFTTVNFGMALYVLLSTDLASDHGIEPSSAVYLLQAFSISDIAFRALSGVIIDYKVLSLESVMLLGYLVQGAAFELLAWFGSLHMMLTASALMGLTCGARIALQAPVIAKDFGLKRMPVVMGAVYFCLRFRGFYQTGLIQKFSSPSSEVDLVNSQTDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN56</accession>
    <name>A0A9D4PN56_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047642"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038844526" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27268" checksum="EFC76BD74021D8B4" modified="2023-05-03" version="1">MRPCAPSQAVGLLLTASLLSGLAPCAWCCLPGLQDYDVCFNIFLERDFPLVEAFLLNRAFLSRGRVLVEPGDLETIGFGELLECYAFHYLNCADLGGVRREYFERLIKAMVSSFQLLCATNRTTLQNLFYDGHCIGSVSDGAGDCRTANFDLATAWKRIFRFRATQRDCSDLVRHTRCLVRALSSSSCRPEATTAYNTTAIDFLFVFCQQDFSDRSAASSGGLCSPSPLNIATVLVTLLSLLKARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPG1</accession>
    <name>A0A9D4PPG1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_019863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPG1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036225"/>
    <dbReference type="OMA" id="CFRRWFA"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="392" mass="43676" checksum="00FF8BC35FC6216F" modified="2023-05-03" version="1">MHKMTATNDITNRMDNDFQNGTVTLLISANATADVVSSASADDILGPRYHKRARIAIIIVMIVASVIGNTCVCWKLVVKRRRRRMSKARVLFLNLAIADLLVACITMTSQVVWEFMGRLWIAGDAFCRLFKFLQTFALVSSTYMLVVIALDRHIAIVTPLAPNPDPWRLAAFTWLVSCLPSLPNVYVFHAVQVAPGRCFCASIFYDSGTPIYHRQVYMGFVFFMVFVVPLALLVTFYTGILCTIWKHSSRSDKVGQQTASSLPLAKVKTLKMTVVVFGAFLVTNVPYMVQEVILAFGNPGVLNANVVALSGVISASNSAINPYIFLYFQKDHHEGSRSTFASLVKNMPCFRRWFARARSKSSHKMATLTVTYSGRHSRTITTANLDMASERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPN5</accession>
    <name>A0A9D4PPN5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPN5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040572"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16963" checksum="B808F19845DDEDB9" modified="2023-05-03" version="1">MFPEESDHGELRLCRTCRDTIVRGGVREFRVTNGFVCPDKPSSLPRFNEVEERMVPPTIPFTNIQRLTHVYVLCGVRGQVINVPIDVQETLQLLPRSVPEGALVDVHRKRRLLAKTVYKSGMVCKKRIYTCLEYLVGTPAFGESNKQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQF0</accession>
    <name>A0A9D4PQF0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQF0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046596"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="25579" checksum="6C6EAC4F025E2643" modified="2023-05-03" version="1">MSSPAVAVKAAEDCPKVVDVRTPSEGHAKPKMPKGDECRIVITDCDGADDATDRDSRVAAWLGQDASAASSALEEGELSRSDSQPRRHHKHRHKRRQRKHHHHRHSSTHSRSSRSDEPAASRCQSSRLVVEVDDDFASECDTVATGRSEGAWSGLAPPDRDERKRKNKRKRKLKRKPGEEDDEDEDSQDGGGKRDKKAEMIVVTVSAVILTIALLLIGITLALTPKIDEMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR03</accession>
    <name>A0A9D4PR03_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_009300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR03"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041637"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF22">
        <property type="entry name" value="HOMEOTIC PROTEIN ANTENNAPEDIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7951452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="302" mass="33432" checksum="8D66DAD84BDD3C1E" modified="2023-05-03" version="1">MPTSTRRRRPITPITIMGIRSMLTTNPWACHLLTTPTTTTCSINNSSSNNPAPACYEPPNVGPYYSAAVPARPPPETHAHVAPTSAAVASKEYGKPTSSVSPFAAIVKPQQQQATAAAAAVPGPELGGGESSGGDTRQQRCGFAARRQRSRDSRELRRERWQRGAGFRERATGVSHKRAVAEQDGQLLPLDEVLLRQAIVEHSSQGPKRTRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALGLTERQIKIWFQNRRMKAKKENKLQGGLLVPKPGNELVSVLQDSKGLGATMLDSVVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PST7</accession>
    <name>A0A9D4PST7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PST7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039040"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044305"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7952512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="378" mass="41153" checksum="D245481ECEC0B039" modified="2023-05-03" version="1">MEGLVAEGGSSPEPCAIGEAGPGVTKRSWQQLRQAVRQTRCRLYGLASRLPSSVTFGKGRLYFLSPLTEGRESSLHYVDLPPHQVQGGSTEATGLAGSSNEGAAGAATAPSSTTAPMLQWRPLLDPKFHRCHPPGRLSREEQLQWERRRLMAWGITAFDYQAGRFVFPAGGSLFFCDDMPQGGPHFPVELRTSLSCARLNAQLCPCNGDVVAFVAAGDLWVTHLGSGAEARLTHTRSVVRDSRQFAVASRKRKPLSIKEKLNILAVVDRNPKRKRVDIANKLGLPVSTVKTVVSKRKEIKTNALVFGGATKQARGARHGELEEALLKWCKQARASGVNFDGSVLKEKALEIADVLGIDDFTASNGWISRFRARHGIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSV1</accession>
    <name>A0A9D4PSV1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_022042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSV1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048806">
        <property type="entry name" value="ZPBP1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07354">
        <property type="entry name" value="Sp38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="224"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7952368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="30952" checksum="5D4C1D245777CC1C" modified="2023-05-03" version="1">MVRAECKSQERHFRDSLKVACVSPRTVSSHGETQPSLVINPMGENKTEPAGTGFVLFCTKGAGEADFTDYKWTGPNGQEITGERNIRVVSTGNSYILSFDSPSPQDSGSYTCSALYGSTIPLSVTVHITFYHDITWEDCPQSQHLILGQPGKIRCRVRGNPVPLVSWLKDREELDPQRYEGKEDGISVPVAQDIDRGTYVVSAMVSVTGKFQKRNITVDVYTQPKISPTVLDSSELVEGSPGTLQCSAEGYPPPLYYWFDQVSTWDEERLSCRQGGLLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT17</accession>
    <name>A0A9D4PT17_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT17"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="685" mass="74572" checksum="1875457B03CCCDD2" modified="2023-05-03" version="1">MSTAMRVEVDGVEISPDQITRAQGWKTAGEKVKQGGVGSLGLTPISQASQDGAKAATDVNGRGNDLGGATGNDLRQQRTKKRINKGKLLKGARMPHLPRGDIKIVMRPRDGLRISDVTSVEISRAIMAAAQVDVIAAREDVICLNHQQNIVVVSTSKREHADRYAIVERIDIRGTSHEVSAYESAPHGTVKGVIRGIPLEDTAQEIQDLVVHRHNPTALQANRMGRTRSVVIAFEGHKVPNYVRYGNLLIECTLHRKQIDACYACGRVGHRMDVCPNPQDKICRGCGIANPGEDHKCEPKCGLCGGEHLTADRACKARFKTPYVVRRRRWERRRAEEDNEDRNQGKRGSKERPQRSASSQRGRSQTPARSSNGGGHQSRSRSKSRSGDGGGGGNRRGKRTSRGSSGRSRSRTKSLSQSRAGSRPRAGSRPRAGSKFRAESIGRRGTTAEKKVGWTDRSSVARVSETELPSLTPSQLPSPRASPEPDSNEVAELKKIIERQNAQIQEQNAQIRALMSKIDALASGSSANGGPQGGNNTEENAGGKRKTPRREPPSPPLGRAAGAARPTQQAPNNQEAMDAEESTVNRETATAMAQIPKEGELPAILAAITQINKTLSAIDARFESLEGEVRTLSVKHERLATKVVTTTVRNRFASLKKKRAEKIKESIAHRRGRIETSEEDETAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTF8</accession>
    <name>A0A9D4PTF8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTF8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="17670" checksum="B52E4A6271C68817" modified="2023-05-03" version="1">MLASGLLVICFGKGIHLSGRMGPKAEGGGGAMLTAEFGGAPAVADDAPVRSFEWESGGGCCGCGEEVGAQIPVLKQARALGEGDRDGEEVRGVLCSQEEDDVGEEESVLVQDGVGRPWCQGNGGGGLLGCGCGRLHRVFRGGGLDFWCLTPARGQEFPEPSYTGPRSWGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU07</accession>
    <name>A0A9D4PU07_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_002894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU07"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048690"/>
    <dbReference type="OMA" id="KECTIDA"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038604747" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="55"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7955696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35323" checksum="0AC18E7BF69F7210" modified="2023-05-03" version="1">MKTERILFTTLWLWSTVGSSVQKCLEEYKKQRPAHTACLPPNKECTIKATHVSKAGIQLILRTHNHYRSMVAMGKLPKFSTATNMQQLLWDEELASVAQAKADQCTNANGKLDHDKAADRFTTKFKSVGQNLAFRRSSASFKGTDWPGQIKAWFDEYYHYPPDSVNSFSPPSDEPTGHFTQVVWATTGYVGCGYADYTVAGVKQMPYMQLYVCNYGTTGNVLTRPVYLAGPVCSACPKGTACVKETGLCSPPEATAAVDEERDTNSLGQRKKSKDGQIKPSTPYRKNDAGIIFTPSWTAVFAVFAATYVTVFTWVTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV88</accession>
    <name>A0A9D4PV88_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV88"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="84" mass="10297" checksum="C254C81C757499D3" modified="2023-05-03" version="1">MPARSGIAYAQKSTIEPNHACHSQWNIFNGSDKRRRWRMAEHRQRGRQRKPRRARQRIDQRHHYDTHTSIRHGLHFFKPPYKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW08</accession>
    <name>A0A9D4PW08_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW08"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="7874" checksum="1794035F64E44C11" modified="2023-05-03" version="1">MNFRQTHDDNYSDCTASHGKVPVDSCGRRLRPLLKMMTGSCAAFGQPTIITSPTAAACEIPAPQQTSASPPLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWA9</accession>
    <name>A0A9D4PWA9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_001244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWA9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056807"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="148"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7955548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="360" mass="40166" checksum="25F9620D9BFE48C0" modified="2023-05-03" version="1">MNNQDVRSEDARAGSDNESGVTVGLYLPKKNIRHSKLFEAVPSELNKRIGSVFESSLSKYQTLRELTEFSSDNIVALDKLQQGPTLKSWVERMLFLGKEAPLSVGTQKNVVGVRSSGDAYDLPDVTQAGQVMEEFYRIANFPGVTGCIDCTHVKIKSPGGDDAEVFRCRKGYFSINVQVRKKRDLGCSFLMLWPAGPARTTTAEYHARVRYEQGDVPGLLLGDMGYACHRYLMTPLKDPENAAEFRYNRSHKKTRCSVERAFGIWKRRFPCLDMRMQIKATTSALVITACAALHNFSRHLNDPLPQDDQVVQPQSSSTPAPAAAHGSAAQPSDALPPGEPVDTEDGFRARRRIIRDYYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWB1</accession>
    <name>A0A9D4PWB1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWB1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21016" checksum="A50FA1BC75678F81" modified="2023-05-03" version="1">MGAARKAALWAEVSDALNALGPAVKAVRHWRKYWSRLCCDSRKLARDVERERRRTGGGRLGGVEGRVLAILDRTGPDSDPIRLFTGDDEHGCSPIHPARSVTKVLEEHVIPTNDWPPVGADVNPIENILGIMNTLLATLNLGSTTADALWTALNAEWKGLRSSHRVVQTLYDSIPRRIQLVSAAEGNMMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWQ6</accession>
    <name>A0A9D4PWQ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWQ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045797"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="427" mass="47378" checksum="5B4B9495D5A5419C" modified="2023-05-03" version="1">MGDQDPIQQLGPGRPHHCASDASDHFGPSVVHIDTSDCSSTEDMASDSDFTVVSSRRLKRKIRRTSPTGRQAPKKASSVRSYTISYVPTSTTDILNSLNRQSLSEYFELVAPGQVAEIRINARKNILSVEVTTKSILDTLKAIVQLGNIPVRAFSAYDKETTTGVIYDVDEDITDSSLEKLLSSSSPIVGFHRFGRHDIVPHTSNDYVSLTITHKRRTFSVIGGYIHPSAKIDCSHLKTVLQAAQSPHINDDTEERNPRQTSPSVAELKDTFYGISTRLTGSGEGHSADLSTQRNLYLISGGWYEVRRQYPNKVNHSEPWLYIKGMDVSVFALVKATLVTLTFRDANWKKKKKEQQLRQPAADVPERVAQTAILLLPSVPGFPSRRRLTGRHDVLPPYGGYTSGCGCLRSNTRMLQARQREPVEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWU5</accession>
    <name>A0A9D4PWU5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_016055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWU5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042658"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043084"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF105">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7957205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="875" mass="94591" checksum="76C32C270F020468" modified="2023-05-03" version="1">MPLEEMVFGEEISRQEDEASGWIVAHSRKKQRQDFTPGDSPGLSAGNSSARPAHPKGPINKLIAASRLPRLPKDHYRVVVRPKGGMDVRKVSRLKVIQALVMAACLGPPQAEEDIVCANEMQNIFVISTPHARNAEAYAKVKQIRVGETLHEVSTYVTPPGDTCRGAVRGIDPELSDDRLGELFVHARNPEVLGVRRIKQTPTVIVPFDGMKVPNYVMYGTNMIRCTLYRRQIDACRTCGKLGHRSDVCPTPTVITCPDCGVSSPPENHTCQRSAPSVEERIRRQIGPAKAGTRSPTSFGVEGDDAEKQTSSAGSSCHSKLPGSESTRGADLILLGRVRVTALARGIGLPPVSGFNRNLPGLNELAKNVSLALSCSQLPEQATARIQQLERENATLRSELQEIKALVEELRQRERTPEGAVKVQQAETQPRGGKRKAADPPVDIEKEFSDFKQEITGAMLAMLLLPLKMSCIVGSIGSTSYRTGGKMLRCALAYWSLSAASAAAVAFGSVLLLRTVRDEIASSLQLSPSAAINVSAIQTTDLAMEMIRGLFPPNIVDVSMTIWPSDDIPRGSELWTYEFHEPCPHRRYEQGTVDSTSPLRRVSGLGLLSFALALGFVLAHNADDRNVLLNFFIHLSNVLAAMGRLLSWFLPLGLVSLTANVILLAAASLRSAHSVSLLLTYSLNVAVAVLVHTFVVLPLVQWLLVLRWNRGMIGFLGQTYVPLVVSASTRSMAASLPLGVSVLEMKSGLDARVVRTVLPMGIVLGRSGSVAQLCVSLLFLTHMYRVDLQGWELIGAAANAIVASLSDDGASPAIVSLLLGVKGFHKEPLVVAAEPLVQWLTTMADAYCNCVAATVCFDIVHEDLSEDDEVAGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWX1</accession>
    <name>A0A9D4PWX1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWX1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055163"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="43"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="27016" checksum="76A56DE456DE193A" modified="2023-05-03" version="1">MQDLPDTDIEHLFPSWIKAKAFTTRLVWLARKSFIFDIGEAGAFYYRGSNTAVIPAALLTRPAFYPGLDPLSYGGAGQITGHEITHAYDVDGIMSDEQGINKNWTTPEFLKEYSKRTICLRRSHQAAEGRVARQEVIDDYTDSENLADFGGLIAAYHAFDSLPEPRRSITLAGLNITAEQLFFISFCVHFCGTVRDEADRHATFKARCNVPLMNMPEFSAAFNCKPGDYMNPPHKCTFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX54</accession>
    <name>A0A9D4PX54_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX54"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="558" mass="61265" checksum="6DC672E8CA770887" modified="2023-05-03" version="1">MADSRMEEEASDVYENNEEDFGWQVATGRRSRAGKKSSDAANATPRNSQASGGDAVTGGDGVSGGGTGPAKATAAAIKNRIVKASRMPQLPEEHHKIIIRPRGGLNLSKVSTTAIGTAVIEASGLTAEQASEDMVCPNFTQNIVVVSTPEPDHAARYVRIKSFKIVETEYEVNAYETAPHATCKGVIRRVDIRDSQSVITRNIVHERNPLALAAKRIKTSGSVIVLFDGLKVPKFVRYGPTLVRCYLYRKQFDVCFTCGRVGHRSDVCPTPDSVQCRGCGALNPPVDHVCTPKCKFCGGNHPTGDKACRQRFQMPYVVRVRRRERGRSRSATRAPAETSHPTPSLQQGPRGRSHSRSRARSRHRSLPREKSRSKSRGASVSLEDGAPGAKPTAGTAWADKVKGTVRIAGGAATPAVTEDNDARIEQLIKEVNALRKANEELTKQVVELKKKAQPSPARVAVARPVSQSTEPSEGDSSPAPKKRAVSTEIDPVFSVLSELKEVIKEIRETTERTNFKVDKLWKWRLTAEQRFKKLETRLGKREITPRNVRGRSKENDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXT4</accession>
    <name>A0A9D4PXT4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042623"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="594" mass="61682" checksum="C02255291F308B8F" modified="2023-05-03" version="1">MSCVAGDTGTVTAIAQSRIRDGELHSNNGSYSARKSKRSRNHVDPTVMAEQMTGHRGSDSIDTLLAYIYSDDKSGAPNSSSNNGGVATENRKGKNVRKGTTSSSSNSSGAKNSLSSPPPGQADEKEVVQEGLSEDVINNNFDSSHRRAVFEDAPLCGGGGGGSPNEKERSFSPSFYSDYGTETELPGSYRVDLSSYSDVDQIQESEFRLVTKKQRRRAQLKKAATTVYEGFHRPLGGGGGGSATGFGSSHGTTATTATGNGPVEDSTVRRPGVHSLESLSQPYQQQQHQRNSVGAASIRHEPPATAVGGGRQHNYTGSAPPSEPSSPENSDLDSVHSLPVSSGSGVAATMVLQTSYADIARMSCRQGRGGTSGNGGGGGCGGAAAANSSAGAENSTAVVVPSQQTAVRPTSQGTEAPAVTSTTTATTPTAGGPTMTAVSGGSVRENVSSYSTECYQSGEGDRSSSPAVVLLDDIGGTPPSMLSEITFGFDVNEQLVQMSLNSQFQCVPSGGTLGEGGEPAAMATATPTVVAPPRFDGRPEELGRFNHRDVVDFLDWEWVRACQSYEKEGSSDSKTRVLYYCDSSSSGGQRQQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY76</accession>
    <name>A0A9D4PY76_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY76"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028522"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="351" mass="39673" checksum="8050C1A9391F274A" modified="2023-05-03" version="1">MFQAAVFIENFSHGRMLPVVCYYEKGQALRPFPMNYDIDDVPGHLCSHVNLAYITLNHTTYTIHEDNTIKFADFAKLKTNFTRLKTFISIGGWNNQTQVISAMASMADRRKAFINDTVRLLVDHNFDGLDIFWLFPGSVDRGGSIEDKVNFVRLLEELYAAFRVHKLLLTAAVPINQQILDNGYDIPEINRSIDGNDTADLNVETGLQALLDRGASKRKLVLGVAFYGRVYKLANPKEAGLHAPIDFINKPERGAFLMSDNIHAYFEVCKNIKFGSWNRSFDSEGMCPYASNGRDWVGYEDAESISKKVCKNIKSGTWNRSFDSEGMCPYASNDQYWGGYEDAQSLSMKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZR2</accession>
    <name>A0A9D4PZR2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_012653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZR2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027634"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="11"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="474" mass="51923" checksum="9933555F5DA80DE2" modified="2023-05-03" version="1">MASSSENKDVAVEGHFGSVRGSVTIIAGVLVSSFLGVPYADRNTLRFAAPVPWHRKLYQFDATSPAPACAQTNDKKDGMNDSTSEDCLHLNVWAPTCGGRICPGNLTIVIFFHGGFFQTGGNNDPYHDGGILAAMGGVMVVVPNWRLGLLGFVSMATADSPLNVGFLDQVEAFQWVRRNAGPFGGNVSDIVIAAQGSGASALGYHLFAYDGSLPGLCRLYEGRNLVLHKPTRSIWYPMYGYNRAADQKRAILARLLCDEGAEKDTWLQCLRSLPVQALFKTPPGALRSLPTFFPILPIMWNPIMWKKFTPSGLSVLIGFSDDEAPAISENFASYLNFNLQDSERSASSVLTLLGIPQEEAAEVALNYSKTQSPGHEKWAQELLSDIVVVCPVRLFAEQLHALGNRVHTYVFHGSDVTSVRSVGREDIARIFFGYAISQGLAIEEQVLSRRVIKRIGHFFKTGNHLALYRIVAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0M8</accession>
    <name>A0A9D4Q0M8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0M8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041373"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12196" checksum="B806BA6E81C8FE38" modified="2023-05-03" version="1">MAKAYDSLSPTSGLPTGATKAMAYQVGFGAIYPCIIAPLSCLMIAARCLTYPVAPFRTHYKDILADVRRVLRRRSSTLAGLAALQFIVSFGLLHMQMKSVLKCTGSLRNHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q322</accession>
    <name>A0A9D4Q322_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q322"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029183"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="113" mass="12086" checksum="ED69F5D941EF0CEE" modified="2023-05-03" version="1">MAVPQHSAAVVSAPNAGWAPGCAWPLHPAAVQPSYHRDQWPIIQAQSVGAPTYRPPAGRRPQRAPSQVVCRRCGGVGHIARNCASRPRQDNAVCFQCGRPGHFQAQCSGNGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q371</accession>
    <name>A0A9D4Q371_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q371"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="11993" checksum="EFE527E1A539B99F" modified="2023-05-03" version="1">MSEISRLKKTVNCIIHAYRDEGYISYAAHERPRTMTGVQDMNIPYAFRTATEVGAAAVVPAKVSAIERRLAKRQLNSHVVAQKPRLCEANKAHPSNIDEATEAAEFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4L2</accession>
    <name>A0A9D4Q4L2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4L2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051794"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14025" checksum="E4290AADD2A24933" modified="2023-05-03" version="1">MASLERRCKNRGVVRASVTRTITLLTDELQATAPDAAQVDSHITYLTQKNVDLGNLNKQILDATDDDAYDEELEAAEDYDRKVSYAVSRARFFLREHANTATATRTSRPEATLPNADVAGAGSSAHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4V9</accession>
    <name>A0A9D4Q4V9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD finger protein rhinoceros</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_005576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4V9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047504"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15671">
        <property type="entry name" value="ePHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15573">
        <property type="entry name" value="PHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000004">
        <property type="entry name" value="Jade family PHD finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000030">
        <property type="entry name" value="Protein Jade-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF160">
        <property type="entry name" value="PHD FINGER PROTEIN RHINOCEROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="814"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="895"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7968091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113071" checksum="A9B6FFEFE50B6966" modified="2023-05-03" version="1">MSSGAKQKRSSIDAGSSCAGTTTGSKRLRRTSACEDDDSRLSSSKAKLPPLPLPPMSKIYNSSYRSNKPAELFRKDLISAMKLPDSEPLDADDYWFISDGWKQEWERGVQVPVNPGHLPEPTVKVIKKKSKSNDFKLPPNKFLRLSHDEFFSNDLHVLTNVSALAEKTCRYDLDCLDQQWLRVFNEERKSLGLEPLPELTMEMILEDFETQCYDKLQREIRTEQGLGIEYDEDVVCDVCRSPDSEEGNEMVFCDQCDLCVHQACYGIQRIPEGSWVCRTCALGIRPPCVLCPTRGGAMKSTRSGQKWAHVSCALWIPEVSIGCVEKMEPIMKISQIPPSRWALTCCLCRERIGACIQCSVKACKRAYHVTCAFENGLEMKPIIDDNTVDEVKLKSYCPKHSKKKEVHRKEASSDDSDKKASSVSREGHHQRDAEATNEEKESARLAKIQAIEAEFYKHVSLKETSEAMSTDPVVVDFVFNFWKLKRKVRNLCYMVSRREKIAKSLLKTREEIFEHQVAMLKPGGPKMSEREREAVILAGQSEHVYDRLVSPDPSGPKPCLRLLLDALEGREVPNLYGLIKKPPSTPTRLPNPYAKQYVNGLRSRRLSMMGGAGESEGCVAQDEDSQGTADSATTVSGRGDVAANQSSVSAAHVAEAALETLCEEQLEAGEERGQTAGGENKLSKDVAEIQQAQDAIKASKKMEGEADEIRKGECKPFAQSRRLEVGNEAADGGTRSASRQEAKKGDISEVDGRVSMRSRRADVLVESSGDLCKVVLRQEPKKDDAMEQANKKFGRTTRLSEARIELVPCDMREFSKNSCPTDEVETKTGSRSRRLRKQTTASSDGEDPQPPTLASLSSNYGKHTSDENVPKRPDRRERRDSVACSVLLPEALSPPRASSLSGYRIPKKAKAPNGMLEDRRGSSPVSPLHEVPSHCYAGSDGYTRGRSHVVNVRRPVLGHHCEGRGGAYVERWKHDLDFAIPTGNSAAPDWTGKLEVKENGSRYPMRYRPRFGGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5I1</accession>
    <name>A0A9D4Q5I1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5I1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027293"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="516" mass="55969" checksum="E8FE44EB36873407" modified="2023-05-03" version="1">MATAMQVTVEGEDIGPAEISESAGWITAFSRRKSTSSRQTLQPCNVPRGANKGAAPASVRKRLTAASRLPRLPTEHFRVIVRPRGGLDIKKTGHFKIAQALIAAAGLTSGEVEDVICPNMIQNIMVASTPSERNAKAYNTVASLIIDNVTYEVNAYMAAPNNTSKGVIRDIDPTLDQDELTRLIVQPGTLLLGHRADVCPSPEDGICRGCGTSNPDDQHNSPKCALCGGNHLTASRDCKRRFQVPYVVRQRRRARRYQKSQEAHDSTGAEPLPPKSATSRRSRSSETRGNRYRVLAEDNSPSPGRASSKDKGRSVSRGRKGYKPDSLKGQTKKVTGGTPPEHSNTRVAQLEKENALLKREMQQLRAEIAELRNATKHNPVQPPAPLQYVEDEAPMEVPVEEASSERPAKKRAIVDSACSSSAMKAKSEIKDAIESLSITVGAIKATLDGLVEGFSSLSLRHDELEKHVFSMSQTPDPTKGKKTSSASAEQTAAASRGIFYDQLAFNHNHGSKPQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5Q5</accession>
    <name>A0A9D4Q5Q5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_022260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5Q5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054996"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11513" checksum="134BB4003898CCED" modified="2023-05-03" version="1">MRLCRTFRETVIRARSPVFSHLSTSLYGLSTIRAFNAQRTFERMFDLKQDHHTSAWYMFLCTARWFGITLDSICFAYITIVTMSLALSSDGGFAFASYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5Y9</accession>
    <name>A0A9D4Q5Y9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_022429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5Y9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031548"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="130"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7963701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="325" mass="38569" checksum="32E6A1E84D526B0B" modified="2023-05-03" version="1">MLFWTTIYGDWYSGLTEEGVAELEYRGCSHRCYIANDRRMLSVSDAVVFYGRDTDPAHMPQERAPFQKWVYWSLEPPWHTPVILLKSLNNTFNWTMTYRLDSDVLNTYATIRKLRPAERPYSKESLKNTWKGKYKTAVWAVSSCKTSGKREHYIEELQKYLYVDVYGKCGENVCPKDKTFDCRELFAKNYFFYLSFENCICKDYVTEKLYKMLLYNIIPVVFGGANYSDVAPPGSYIDALSFESPMHLAHHLNEVARNFTTYERHFQWKSKYKVEPLSGYDLCNLCRKLYSEDFKKNSVVPDMYHWWNTKSHCRALNRDTQKFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6H2</accession>
    <name>A0A9D4Q6H2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6H2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038295"/>
    <dbReference type="OMA" id="NFRMDDA"/>
    <dbReference type="OrthoDB" id="6509541at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="14109" checksum="9A3A236B4F65184D" modified="2023-05-03" version="1">MDGGAWRGSRRQWSDGGGSKAGSQWSSFDVGLPALAAGFVTGALHVWLLQPPYVARRSAAAAAGACLGALLVGCFVNVQRDARVAKEASSQPEPARSWNDGERRPAYSDELPRGPRTPRKAVILKNFRMDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9X4</accession>
    <name>A0A9D4Q9X4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9X4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046234"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7969372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="299" mass="32948" checksum="1BB3B897E5D2631F" modified="2023-05-03" version="1">MITGHVFRTLDVRLDVDSLLRLDPHAFDVSVCRLGVLLVVVAAEAIGGKAHSDSANSDDDTTSVTSESDDDVESAPTGSMVPATDAVVASIGSEMGTYVHRVLERPKVMPSDHPEKVHDWSGWPTFPPKANPNRQRRAIVPTKLPLVKHVNSDEFRPIMELQINIHGRRPAPSFLFNRLMDDLQYMVWLTFTDVNGGGCVGQYSHPESPLPGSSWRGKVVSFDRIKLFSDEGYNKQLRPPITLKIDATYRIQVNIGAVDDSGHILSRSVARQFVGNAFIAVSHACRNVPSYLFVTLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAP3</accession>
    <name>A0A9D4QAP3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_020657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAP3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032200"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044653"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="9">
        <location>
            <begin position="132"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7973030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="349" mass="38840" checksum="D602F2CADA04806C" modified="2023-05-03" version="1">MTRPKSWTVYRTVARTDRDPQCHRQEDGARGGSCTRLAVETNNVGDASARGPNPSSAENRSVDACAAPCPRLTPPSRTRPSPRLDVEVIHPRGTCRTTHLSIVVHARAYTAGPAPELQPVQDCGRLLNRLAVSLLSCMLDVPSRVQWNIIVSPIALTSALASLVAGCEGPTKEDLCNLLRLKPQEVEVIVERFKTESAEHTFYVANRMFLQSNCPLLATFRSQIEAKYMTTAQNVDFESPDQTYVRAINEWCSNATNGKVPAVVTRKTFGASSSMVLVSAVYFKGLWKDKFYPNATHMMKFYVSRADTLDVRMMTRTGRFPYAEVPSLRIRALEVPYRTGKLSMVLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAX8</accession>
    <name>A0A9D4QAX8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAX8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054164"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039600855" evidence="2">
        <location>
            <begin position="18"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7973072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="766" mass="84987" checksum="1AA7C1A409992195" modified="2023-05-03" version="1">MAVIFVVVFGQLHATAPRCHEPRKDSGGVGVTTSARDRTLSGNWISTADNTASSAVRMAHESVKGLQRWSSFRHPPATCHDITVPPPSRDQQSEVNMILRMSSFIALFILAAVIVAILLLPQSHHTSGDEKSICSTSDCAYHVHVLGLNRSRTAKPCDDFGRFVCSGWVSKYRDISFTVQMDAVMDWITRLSQSSRRANWTAGVTGRPLNMMRVCVEGASSEDDALRELVSFVSGRSFSWPTSDWKETAVVQPRLPLRALLELAVRWGLPLWFRVDLVPSHREDRISVVISPSPFPTAFHYLHSRFLRYADVYPYYVQEFIDTVFSHRPAAPAFETFIRDSVYMQGHVFGNMTAAAAAPYFAPRVVAVERLQSLVKNVSAEDWIIALRFVGTTSLNNDSLVLAANKNTVTAMDTLFGVYTARDIWFHTAWWFVQAVGLVAVNSLSSELKVHPLGKALKSIICAIHVDASYSALLATNYKSHLTTTEQHIVKRLFDNIRAVAVEKVRSFTTLTSSSRSALATLLENTDSAIWPQHGFDSSAALEILYGSGYTQTGNFFAEWLWTRLQIQRASLTAVHTEASTVFGLLLRRLGWYNAALSVISISPAALAPPFYYTGGTSAMVYGGLGYIIAAETICALNSLYYIFNDDETLTPRDVAGHRTIWSKFSCDSDKYHLLFPDHPAVDVAYSAYVRFKNQSFDLPLQGLKKYSPEQLFFINYCHTGCYINNKGAHVNPACTAVLSIFAPFAVAFSCPPGSVMNSAHKCGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QB57</accession>
    <name>A0A9D4QB57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QB57"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10149" checksum="F9B26AA9CB3362B1" modified="2023-05-03" version="1">MERTPEDDAPSPAETSAEAIRPNPAVAGVARVSEADRVCEWLRRACNTDYLVFANFNVECLQEPLSVYFTDHKAVVVKAKRAPSSVQRSCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCZ2</accession>
    <name>A0A9D4QCZ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_012136</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCZ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="39"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="187"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="447"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="548"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="11">
        <location>
            <begin position="677"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="11">
        <location>
            <begin position="944"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7972448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125962" checksum="C9E558B362CFEA5E" modified="2023-05-03" version="1">MAWLFGSGEQDLTRDKLTEPISDISEKWKLLPAFLKMNGLVRHHTDSFNHFINVEIKEIMRANERVTSDADPDFYLKYLDIRVGEPNIEEGFTVGRRTTPHECRLRDMTYSAPIVVDVEYTRGRERVQRADLPIGRMPIMLRSANCVLANKTHFELSQLKECPYDPGGYFVVNGNERVILMQEQLSKNRMIVEEDRKTGGIMCQVTSSTHERKSRTVVSVKHDRYLMKHNSFTEDIPVVIVFKAMGLECDQMIVQMIGTSDVVQAAIAPSLEACHSAEVFTQTQALQYLGSKLKHRRMVFAGGAGGGGPRKSAVDDAREVLATTVLAHVPVEDFNFRVKCFYLAIMVRSIIDAQSNKELLDDRDYYGNKRLELAGSLLSLLFEDLFKRFNSELKLAADKCIPKVRATQFDVLKYIRQDLITQGLSMAIATGNWTLKRFKMERIGVTQVLTRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQFGMLCPSDTPEGEACGLVKNLALMTHITTDVDEAFIVRLLRNLGVEDLRLLNGEELSDPSVYIVFLNGNVLGVVQDHVRLLKTLRLLRRSGYLSEFVSLHTSNLKRCVYVAGDGGRMCRPYIIVEKGRPKLTNAHIEDLTRGYLFFNDLIRRGIVEFLDVNEENDSHIALREQDITLQTTHLEIEAYSLLGVCAGIIPYPHHNQSPRNTYQCAMGKQAMGTIGLNQRNRFDTLMYLLVYPHRPMVKTKTIELINFEELPAGQNAAVAVVSYSGYDIEDAIVMNRSSIDRGFGRCQVYRTQKCVVKKYANQTSDKIMGPLVDTLNMMPVWKHRALDADGIAHPGTRVESRQVLVNKWVPVTSATEPEPGQPAKVEEKEVSHVFVHFLEVSSQQISAVSVVCYRSLGSAVVVSMPRCRCPRKFHMLSHSRMPEIQEDLPFNDQGICPDLIMNPHGFPSRMTVKDVGEELIQRGFNYLGKDCLTSGITGELLSAYIYMGPIYYQKLKHMVMDKVHARARGPRAVLTRQPTEGRSREGGLRLGEMERDCLIGHGASMLLLERLMLSSDACEVDVCQTCGLLGYSNWCHYCRSSSAIATLRVPYACKLLFQELLSMNIIPRLELTSHISSRSVAAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDH6</accession>
    <name>A0A9D4QDH6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_005366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040976"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044919"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7975810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="869" mass="95756" checksum="0FD460C53E029298" modified="2023-05-03" version="1">MNFLSSRYKLIQRSEGQVKPLLDEHVALPKGLPPAELDLDALMRASQAWQALQDALNSTGGRSMPLDPLPEWREQATVQCNRKSDEPGNFDPHGGVFMFDIVNDPCETDNVASSHQEERDRLLEKLNNYRTLLSPGQGDTKSDERGYPEYHDCLWSPWGWNDVSFHGSRQIPTPNIDALAATGVILQRHYSASTCTPSRTALLASVYPAGTNVGYQAFPPASKRSLSLRVQLLPQWLKRLGYSTHIVGKWHLGYSSIEYTPTWRGFDTFFGYYNGASYYFNHTLYWKGHCGLDLWRNVRNRTRPVTNLKGVYSTDAFTEEAEQIIRNHDALKPLFLYLSYQGVHSSCDGCTAEAPRAVDALDESVGRLLETLQSRGMLAASVVLFASDNGAGPLATANDELPNAGNNWPLRGGKEDAWEGGLRTPAVLWSASLRDPLRRPPSQQVLHMVDWGPTLYAAAGGDVSDLGDVDGRNFWTSLTTGEGEGRAEVLLELEGQRQTSALISGRYKLVKRPGGPTDELQDRQVAPPRGQPPDDLDLDDLMRSSAAWKALQAALRASNSTSTSTSPRPNWRAEATVRCGDDNGSTDAARNFDSYDSVFVFDIVGDPCEARNLASSEPETWNFYCNYIVYPDVVAVSSDAFAAPDGVYSWKEFFRMLNETVRGKPGALTFLGVRLNSQDDAKGFAADVQNIDGLDCLVLQTHLSDAVTAADSCIAQLVTYKNSLSAVPSFDNAMKAQSALNDSHSGLRLMFSSTLAVVDYVGAGGKSSPTQPGQSCEYNVALDVDVICNVTSTDAFRTDQLNGVWKAKYNVGTMDAYLNYSSGGWAVFDIERDVKAKCFHPDPQHRLWSIALKIKKFNEARKAAKKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDV8</accession>
    <name>A0A9D4QDV8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDV8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18346" checksum="37D389B9E12712C0" modified="2023-05-03" version="1">MLEAFGKVLGMDSEIIPGFKEISTGNRRVRMVMSKAYPNLFKVDGKTIQCEYEGVVRLCRRCNLPGHHANKCSTPQCARCDEWGHLRCKAACKRCGGERTTVRCKVKTYSSAAQRFSPLQAPDSAEGNAREQSALNQADTHKQGKRFSDSTKCSQGAGEGRGRVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEY1</accession>
    <name>A0A9D4QEY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052419"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7975473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="645" mass="68775" checksum="54BFB222D12E3E27" modified="2023-05-03" version="1">MPPPKEHFNVRTPPGTSVDEVIDALEGLVGIQDIYSVQHHGGFDFQVGVNSVAAVQTLLETGGLRLGTRTVPLVPVARQVASVTCLYLPCYVPDNEVVTGLKSYGTTLRIEEARYKDRPNIRTGTRYIKMDMRLENPLPNFARVGGHRATFEYRGVRRLCRRCNQEGHFKAQCDTPHCARCGVFGHRTDTCTEPCRRCGGAHASVDCTARKSYSMAAAMDVDEFPALGTATAAGQTQRRMTTLRPAKRPKPKGDGPEPQVIPEKTLAQAAAITASTAPAQQQEGRQTDAPTLASMRSGERQEEEGSHGHAEPNQAAAATEAERAADSGEGEKRGVHGARSANGDDEGEDDAASAVSWASVDETAAEESGHEDGQGVGKEDRPEARKGSQGERKLNLKGRTGPAASTAAHSPWWNKTGDDDVPRGREAPQPANDQSVSGSVEQEKSRKAPGEGDAPKPTEPSISSRKQPQPEPAPQHGGAAQQHSREGAQHGVQHGEAGGKTSRGEKTAAAVLEAQKPAGTPSSDELEPGELVIDESAPTSPESPKHTQQQPLSMPEGVGRGQNSRSRDSKAAHGGTLFQSLRPSGPGAHKADGGRPQRSVKKVRRDAAGRLRSRTSGSEHEEATSKQRPSQRPAADDMDTDSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFN6</accession>
    <name>A0A9D4QFN6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PC-esterase domain-containing protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFN6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044474"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7977032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34247" checksum="FE216E73541DCC64" modified="2023-05-03" version="1">MEDSSYGDNLVGHGKKHNGRDYREERLYRKNRTSISFYFLTRIYSEYVQRILADMTVGYAPDVIVVSSCLWDITRWGPNGVQEYKENLNRFFSDLNRILPSTSLVIWLTAAPLAQDVRGGFLIPQLDFLKYSLRFHVLEANSFCRETADRYGIDVVDIHYHLRMFLEYRAEDGIHWLPKAVRLCTNLVLTHIAISWGFKGPSCHSFLVGSEKEIIRDGKRGFHCIPDEDSASEQNHSADLLFNAALGCHQRCRRGPAIAATKGTKGQLERQTVSQATTEQAAMPMVAWTRAMQQPKPAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFN9</accession>
    <name>A0A9D4QFN9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFN9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038161"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="16748" checksum="848BED27C25D3219" modified="2023-05-03" version="1">MTSGAHGGYDINALHALSAVNAGHGGGGGGGYGGGYGGHGVPIVRVGYVKKPYVSIVVKFVKVPVKTVGIGIRPVLTYKVAHQVKVGHPYYGYGHGFGHGYGGGHGYGGHGYGKGISIGFGGHGIGIGLGHGYGGYGHGGYGGYGHGFGHGYGGYGHGGYGGYGGHGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGE4</accession>
    <name>A0A9D4QGE4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057530"/>
    <dbReference type="OMA" id="LRYILCE"/>
    <dbReference type="OrthoDB" id="6481312at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039039174" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11644" checksum="BA01A50089446B7A" modified="2023-05-03" version="1">MCRVSLCVLVLLIAVAMVAGQRGRPNFDFKPDPPRHRLNVFGSASGNSGRNFNANVGVRGEYDLHRSKNGGRITGYAQGSQSFGRFDGHSYRGKPQGEVGVRAHIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGY6</accession>
    <name>A0A9D4QGY6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cement protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGY6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039129522" description="Cement protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="19684" checksum="F7430AE41B2158F5" modified="2023-05-03" version="1">MLLVMVFATIALFALVACTAFAEEATKKDEKKEDKKDVEGRGGVLGGLGGYGAGVGPGLVGSGLGGPGLVGGGVVGNPALVGAGLGHGVGLGHGVGLGHGVGGGFQSGYGSSAGGHQSGYKGGAAGHNQGSGGFAGGSSHRNVNAYNNNQGYNHNSGFSASDSKSFGTGHQQGSSGFQGGAAGHQGGFGQSSFGKTAGVGHAGVGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKS1</accession>
    <name>A0A9D4QKS1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC23-DDH2 WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKS1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027652"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC23-DDH2 WWE" evidence="2">
        <location>
            <begin position="265"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="737" mass="79952" checksum="625331CFCB79C541" modified="2023-05-03" version="1">MRKDESLSYPQGCLGATDGLSTALRRGDSDYDDCRDRCDPSYCADADTFLGQEPNKAQQFPTASEKGGASAADSLPSGPFSQLQQPLRPPPAQMQAPPLAQFAGAPPVAPAENISAVPDTTFQMSQPMPDQTSPALAPPPMGPPMNFHRQSPLTHASFLRQTAHSSHTMAPGPGIGATLPVGQSQEALSYQGPSQNGPPPHNFYASSSQADAFSHGPSFTATTPASFEQPQHTYMPDHAQLPVSPPDATYVPVRPHWFYNKEIENKNRFVPYEEPVAFILEDHYRKAMASGCWHQKLELPGNQTVVMHNSSVMVHFLPSSHPDEWGNVSEGQTRPRVVKRGIEDVDTIEEGEPSHIDHLVFVVHGVGSVCDFRFRSVEECLDDIRHISLGLIKSHFSLPSQEGNIGRIEFLPVSWHSTLHSDATGIDSALKHITLRSIPKLRHFTNDTLLDILFYTSPVYCQTIVDTVGSEINRLHSKFMERNPGFKGTIALAGHSLGSLILYDILSHQSDTSSQSSSTDVFVDSPKAELTPSPTSTHTSEEVSDLLQNADKDVSVESVFQELMLGDYIAKIHEEKIDIETLSQHKAHLAQPAKAAPHQQVSLSPQTSVNSQPGRKRESVASVNYNMGMAGTGQLSVSYPKESEDTVLLILKELYALQGFAPQLATGRSASQPKMHLYNPAAPLGNTSVAVPPPPMSLPSPPNNTVSPSGVPPLPPDGLSPPPPLQGFVRVSPLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QLD9</accession>
    <name>A0A9D4QLD9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QLD9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056676"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23893" checksum="73FF716AC5D47F75" modified="2023-05-03" version="1">MVPPMTLDSQRHLAVSGEEGPLRPSSGHAGPFRGGSDCGVALPGGKPLPPSGDKFKGGRSRGPPSFRIGEGTKDAYKGGARTTTPRTNNGTHFSSSGPDVTVDLTTPHRTLVTRGASGRRLANYTMAFPLPANLYMNPPQANDKDIYITVEPPRRYAVKVFGGQPNEQQWLRKAEEFIQVMRKDRRVNLDHFYVARYDLIFWVLERRNEIWLSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMK8</accession>
    <name>A0A9D4SMK8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Secreted frizzled-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_007455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMK8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040925"/>
    <dbReference type="OMA" id="GGQHYDY"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039489902" description="Secreted frizzled-related protein 5" evidence="10">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7935433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31327" checksum="E79FC7A0B06B111B" modified="2023-05-03" version="1">MGFVPLLLPALLAVASAAGLDGFDWAGRLAQPTCLEIPANLTLCRGIGYTRMRLPNLLEHDSMAEVQQQARSWVQLVNRRCHPDTQLFLCSLFSPVCLERPIFPCRSLCEAVRRGCEATMAHYGYPWPDMVRCDKFPLDNDMCIGVQSTAAASEASASVACRACQQANTTESLVDNYCRADFVVRARVKRLQGSQLQCKRSKLLKLREGLPRRQLRRPVLKAPDFERCCGPLKGQLLLMGLRAENGSLAPLLIMPWRRTTAFRKALRLMRGVNCTNPLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN27</accession>
    <name>A0A9D4SN27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plasminogen receptor (KT)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045607"/>
    <dbReference type="OMA" id="GNKMERI"/>
    <dbReference type="OrthoDB" id="10256697at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17255" checksum="1896C7EC86AB5481" modified="2023-05-03" version="1">MGHAWSQPADNTSQQQLEMQNHQLERQIYMKYLMHQRLVAFKIAHARELFFWITAFYVASSAALFVGYRRTKKPLILAPILPMTFILAYQGDLAYGSKLVRIKGEAENIMSFEKELLELPHNVPTVGGIDEAREKAKDEGSFNRAHDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN52</accession>
    <name>A0A9D4SN52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium channel modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_018845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036558"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033570">
        <property type="entry name" value="SCNM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031625">
        <property type="entry name" value="SCNM1_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031622">
        <property type="entry name" value="Znf-SCNM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297:SF1">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15805">
        <property type="entry name" value="SCNM1_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15803">
        <property type="entry name" value="zf-SCNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Sodium channel modifier 1 zinc-finger" evidence="12">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium channel modifier 1 acidic C-terminal" evidence="13">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7936138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="309" mass="34279" checksum="C2E3665053934595" modified="2023-05-03" version="1">MKCDDEVWCVISTSRAGDLASSEIVGCSSLKRYVYDETTKRRVSEILVSHIPEDEALLLKNGKYACTLCPHRPVLDTIEMLAMHRKGKRHLINLTRHLSHTKWKERELQKRLQEANTASGTVATSFDRTKLLGSAPVKATKKAPRLKLMKSAPYSSCCKKKGGDQEGTGVSGTGEAKTPAVLQNTENPLVKAYIKKTQLKNSFTAVVEQSKRSSTTPSSTNLRLDGSSQKCDDGESIARPRKAVSKGIKKDLTEEEAKEKAKAQYFLNLRMSGWKLDKDGKWVKDENVEFDSDEEEPPPFVDESGASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNV2</accession>
    <name>A0A9D4SNV2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNV2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052824"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="19515" checksum="7F8C9A0416AA61B1" modified="2023-05-03" version="1">MAEKPAAAANGSTFEFELANDVLFEQCMKTDSRERRSLGMARKQLAEFGLGGWPYTQPHHHDVTFTNVLVTASRLALNLGLAALANVRVFGSARDRTFEIDDPVRLLRKDDLSGFEMKARALVLHRQLIASVFFYFAPRRLGTFYKVQEQIQLVSLILAMPPGGLRSAASAPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPD2</accession>
    <name>A0A9D4SPD2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_015305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPD2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030807"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054004"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038933070" description="Vitellogenin domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7935944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="423" mass="47525" checksum="73CB9A5E672D5BD1" modified="2023-05-03" version="1">MHVLVSGIPLLLLADLVPTNQSSGGVVYEVRATVTLESPEQNVDEGTIIRYAGDLAVYPLVEYEISLGAPAWIKSVYKTVLTLLQNQVEAPRESPAVSSYYEDGVSGYCRVTYEVHSLTNLHIEDRAYNVTKTKHLDDCLQRRHVDSTSNTRRHPADRTKHLANNLLPLPLDNTFENQPFTGRPEDLNKVNSEVTAHEVSYYSVNDSLIESALFDSLTVLPLITGPALVRAQLQLKLASHAAPPMGTAQFDRERRTSLKLNLSEVVAYLNVSAYSDLVVEPEVFTQLLDEVAEELASLELNMTKKSPVIMLKLARIISLLNTEQLKQAMPSSLLNKTSDLEPKEQLLRALYIELLGNARSKSTAQMAIHLMKEHILSRQEAARLFRDLSAFFMTYIDEDTREMLQEYRRFSGYTSQSSNVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ75</accession>
    <name>A0A9D4SQ75_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ75"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12254" checksum="7AC1613906949364" modified="2023-05-03" version="1">MRLIAHSTDEETWHTTNKAQADDVVLLRRAIRMCGHDACVDPIWTVDLCAHRVAARVPQSRRQALVKNELPGQSSIRRTDSIRPPCTEYSPVREAAVKPGDAEDAGVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR67</accession>
    <name>A0A9D4SR67_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR67"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17441" checksum="0FE600E6BC6422D1" modified="2023-05-03" version="1">MDIGTLPTMVDHNYESFKKPMRTDKRLPRSAQYAPAAKRGEKQTSQAGGVFRRAAEVPVGNCFVDAARYGNSNRYTVVPADQAVSVIYAASTECSSSSAAEEVAIIIAFVDEKRANVVCYSRAAISAFAVAAIFKELRRIFGDKGRSAPERRANSNLSIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRB0</accession>
    <name>A0A9D4SRB0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRB0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041064"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="193" mass="20268" checksum="16A0FBFFA1BD281E" modified="2023-05-03" version="1">MSGLLACTPPSFPTPPPSSEGTTVTQGERNSPSLALSGDGETPPPSASLDFDFHLDLDDFEGMDLGMLTDSGPAKNQVPRNHYADGGADFSDPALSMEIELSDWLDVMMPQTTTSSSTSALPNGQVSSSSATPCATVLSSAAAAPNATQHDPLLSTNASMDVQDPFDLFAVNDADFRAWDDFRTSWDSADFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STS3</accession>
    <name>A0A9D4STS3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STS3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039479986" evidence="2">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="170" mass="18704" checksum="BFC0D8B7BDDAE8A5" modified="2023-05-03" version="1">MKKLVLILVVVLLCEEDQGRFLVGQAQFRSYLSRIDQVDKASLLGRARDQEEAARFHVLVGAARTVVVVCAVLASVAFLNKCSVSELRAHRFIDFVGRHEHNHEKHIPVGGPLAAVRRIGSAVLVSAAFPNKYGASEPPVHPSIDLCSRKRNDSREVEDFQGLVPAVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STS9</accession>
    <name>A0A9D4STS9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STS9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="389" mass="44101" checksum="1CC460AA298551CA" modified="2023-05-03" version="1">MTSSTLLDVLLQPAPDRQLRRMTLALAITRIMYQYPYIEITKTQKSKLETLLRQISRTILGTPQYAKFDRVRGTAILPNLEELAQLHREAQFTRLNLSAQGYTLLWELGYDISSPVAFEATRPPWATFDQITVEPVPRHMDRDTQTGRREARVQHLQETTGEWILYRDASPSQTVEGFRTGIASEGQPLSWGFHHNISTQCMAEITAIVEAVTIPNPNAHCLLIRTNSQAACRAFTTGDIPDAHYSTITKHLDSHPSLRVRIQWIPGHSGIRRNEVAHAMSRVSLPGPPLWWSDSLKRTKLLAVARLDRRERLDEVRNNRRVYPDPPHSMTRREAGLVRLACSGYPDNAHVLWDCPGGRAAMGESLKHIPTNLRPATLEEWLADSSPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUB3</accession>
    <name>A0A9D4SUB3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUB3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029448"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038637408" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="15047" checksum="0AC450EE5FB633F1" modified="2023-05-03" version="1">MNTLVSIVIAAFAAAFAIFHTYPAPPKSPLLYQWEKEDGGSYFKFQDYDIFFKGKFRLLMIYGPADPVNKPPFHEHYRKLVPGSRIHILHEHVGHYVHLEAPKEVVAGYLPFLESHGVKTKTISVALPDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUD4</accession>
    <name>A0A9D4SUD4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUD4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038601"/>
    <dbReference type="OrthoDB" id="6476672at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039262182" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12011" checksum="8E0E41F1775DFC69" modified="2023-05-03" version="1">MASGREYDRTKRAAILAACSLLAMLWDAAEGQYPPGPPACRSWYQECGIQRSYPCCGNMVCWRGRCINRKEDRRGYVYPPDNYFPPPWYYQRFAPVYPVNFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV06</accession>
    <name>A0A9D4SV06_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057581"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21088" checksum="BE21629CDE40731A" modified="2023-05-03" version="1">MVLRHNYRRGQDLRDAVCYSCQKKGRLASKCTTPKQPSGGNKQTVPKAPTACVGRVNDTLYGSKFRCAVVTAQVQGLGEISAFPDSGSNVTIPAASPASNPKIEPWIKPPLLVVGGSSIIPEGFVFLRITIGPLSAVVEAAILERNALPLNLGEDCIYAAQAELYFKPPKLPVIYQPLLTLSCNAKRNCCQGCQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVD1</accession>
    <name>A0A9D4SVD1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVD1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031215"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="221"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="554" mass="61846" checksum="ACF2653DC0434AD6" modified="2023-05-03" version="1">MDDNVKTDSSDRNAGAAWVARSGKVPAELQPVWQSWISSGTISLHTNYFHIKSKSAAFKECSLVFDGKKNIYTVKEVSSQEVTYSVNIGEKSKQDFAVTLKPAPNIDMDELKNRFDPGVHQKHIQALDIIIRHAARQSHESVGRYFFKAPENHTLNDSKTFAVLAVDCEIDAGKIGTELKNACNELGITLCGDDSKSISTKDKDPLSEATTAFRDLGEKDLVLVVLGNAGLYAAVKAAADVRVGVLTQCVQEKSLTRHRLWRNICLKINAKLGGCNNILCKTWSERIFKDAIVIGIDVNHPAPGDNHTPSIAACVASMDDYAFKYHARVAVQMDGDQAVARKEVVMKLQDMVLNLLRSSMDYRRKRRRPQRIIVYRDGVSEGQFKEVKAKEVEAIRSACRQIHRAYNPSVTFIIVQKRHHTRFLPVHEGQPVDLNVPPGTTIDNVVTHPENTNFFLCSHQGLLGTSRPAHYHVLCNDSGDKPNELQQLTYDLCHLVARCTRSVSTPAPVYYAHLAAFRAKNHIEGSRLDRSASAQQYKDAVQVHEEIANKMYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX72</accession>
    <name>A0A9D4SX72_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX72"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026398"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="268" mass="28479" checksum="16E101FB3A8749A1" modified="2023-05-03" version="1">MPDGTAAAACVIPSKAISRQCRLPFPASSTAAELAGLHLAADLLAEGIPAEPIAVLCDSKAALQTLANHRRAGLTGNLLATKFRALAASGASVSFHWLPSHVGIAGNEEADRLAKAAHQPGIPITQAVAARDYSQARLKKLLVTVHPDRRVANGQGPKPLPETGLTRREQASLLRLRTGCVWTAARRYLKGRCASPACSRCGDPETLEHLLCTCPGLAKERSTVTTAYRRQGLPATTLEHLLFPSRSHLPALRSLADFIEETGIAAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZL1</accession>
    <name>A0A9D4SZL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028887"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10379" checksum="B9BE07910AB8EF8E" modified="2023-05-03" version="1">MTMKGLYGVTVKGTAAGDVTPGYASDESSTSSSMGGGSGVPRHPSSSKRRPRVAAARGILQRSSYWDRRVEQGLLSDSSVTEEFPPLHEGHPDKTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T204</accession>
    <name>A0A9D4T204_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T204"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038779929" evidence="2">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="16905" checksum="9406441207A2D5A6" modified="2023-05-03" version="1">MKAHSSRTWYGLRLASSLLVTTLTVALLFSETAHAGRPVHPYPHLSRRGRELEYFPGVGLVEPLGLLAVASLPLFVLFSVMWLVLPLWFKFHHFGLYGHGLVPGVLPGAAAAGVPVAGRRRRRDLLSQQRGGESLTEVAARVVKALREGLEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4G9</accession>
    <name>A0A9D4T4G9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4G9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050218"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16511">
        <property type="entry name" value="vRING-HC_IRF2BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="6">
        <location>
            <begin position="334"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7972646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="427" mass="44342" checksum="37B92994410DD726" modified="2023-05-03" version="1">MSALMSRSHRQHCYLCDLPRMPWAMLHDFSEPVCRGCVNYEGADRIEVVLETARQMKRAHGFPEAVARPLYKGLNGAPPPEVVPQPQQQHRAAAPGAPMAPVMDRFERRTAMLEYSQRMRGADPRAAQASGGVVPCKRERDDDDEPSSKRAAALQALDEAVPPRPPLTRGESLPTAVMGVPFDVRYKKEMVGRVYSFDAATSLKNAPGYPSVCSTPSSTASSLSPLSSRAAQSPDSGGAQQNGAPGPMAALLTVAEAVPPTSPRNGVAPADSATSSSVAATSAGRPPRQSPPAATPPSVAAAHKKSSRHAAAAAAVAAATSAAAAAAAAAAATLKCTLCQERLEDTHFVQCPSVGQHKFCFPCSRDSIKSQGAASGSEVYCPSGEKCPLVGSSVPWAFMQGEIATILGDEYKLASKGAAAAAAAADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5K3</accession>
    <name>A0A9D4T5K3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5K3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028660"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="27685" checksum="DA75FFFC3953B51C" modified="2023-05-03" version="1">MDDGCCRYVEGVWIHNLFQEENVRSAMRYKPRRGDVVLVTYPKCGTNWTQFIIWNILNNAETLADPAEFNLMCPFIELTGAGAANNPKRRGGITTHLPMRAFQPVEWAKYIYVARNPYDCAVSYYHFSKGLTPKTFTDVSFERFLSLFTSGKAIYGDYFDHLLPWYERRDDANILFITYEQLKADTRGEVLKIADFLGEHYGAALREDESLLQRVITACSLENMKAFFTDKPMERAGYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6A6</accession>
    <name>A0A9D4T6A6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6A6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7981649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="453" mass="48904" checksum="A50207987E337E2F" modified="2023-05-03" version="1">MDTDSDNEASPAGVPQTSATPSPSAAGDSRPTPSNPIEIVRTGRLAMSVPSGRHMLPASYIDQYRNVTVGSPSTPPEYYVPRATTRRAPANRVALAAAAALESNRDRQPLLMTDAYTVPLQDGTVSPMQYCIIGLLFAGLCVAAALVVVDAPGGKRTTPLRLNEELRHPGRRSPMPSYDPPELVNANAVVVIPDRQHAPVDLGVNVSGLGSETVSGAKPENSVDTTVAAKIDAAPLATEVGSMAVEGSVRPDSCNRYYYTHCTKPTANVFHYDPDQMACVPNTRRGVQLCNRGANRFSSWERCRANCLQPDRVAELCFQNALFMPCSKQDFVDALWYFNGTSCTRWTFYNGHCPSGECGVYETFDQCSRHCVKHNSTSTSAQCEVPPSGEWSLALLRYPFFADMQAQGEARCLNASSATLFGRLCLAGSNQFDSIEACQNACLEGPVSPSHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6R5</accession>
    <name>A0A9D4T6R5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6R5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038251"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046618"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21407" checksum="B9DDF286A129C601" modified="2023-05-03" version="1">MTAQQPELTNGWKYTLTGFGEFLEMRRVAFAEPMPPTRLCGVCGVLPRRTLLLPCNHIAEHLTQCGGGKIKCCKCNRPVFRNHAVNHYRSCTGLQHAATAGAAAKGDKMADIEKSTRELMLRQGRRTGGRAKPLHEHFGRQAMVDHRVVRKPRAGVERWGHWTIKKNWQDIELKGYVDRGALYVNVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T733</accession>
    <name>A0A9D4T733_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T733"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21056" checksum="46E1BFB240D4748C" modified="2023-05-03" version="1">MSGSPASQADQLNSGLRHDASLPVTDMAGPVTSGPYHRATKPGTFRTVFKFCDVQSKRESLVSQKIIETIEVQVNEIGGYTVGIECELRRDDRGAINVTFIPYLRGSDLEGDLDWLSDKKLSVILTHPHRQENDIELAVAIGDEGRVLKQVRPDCWIEGRRSEPVSWYELESKGLVFHDTLYVTLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7V6</accession>
    <name>A0A9D4T7V6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7V6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11952" checksum="76DAB443715F32AC" modified="2023-05-03" version="1">MEALEGSVADCLLPCTASEKETCQIVTKLVTLKKVLLGSPFEIQEEPETYNQLSITNLTLITPPLQDMDSRHIQEYSELLEWLLTTHRCIGVIVFEEPTTKGPVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T895</accession>
    <name>A0A9D4T895_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_000112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T895"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026294"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001842">
        <property type="entry name" value="Proto-oncogene receptor tyrosine protein kinase ret, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055162">
        <property type="entry name" value="RET_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22540">
        <property type="entry name" value="RET_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="627"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7981602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="931" mass="101146" checksum="6E033F6A1785BDEC" modified="2023-05-03" version="1">MVVGYSTRPESRPTEWILVVEATVNANGMTNSSRTQLVVRLLSEEQRSKACESMRKICFGSEDGLRFEYSIHEVASAGTVLDFVRPPATRALCPDLEPTYTLRQDADKWLAFDENSGQLRLTRTVLWSELPAAASSVVTARLECSVPGQPNETGKVSLQVNDLDDQPPREQRESDLVCRTSVRTLQKGYTLGCRISVLDGDSKNANNLKVRVEQDIRNLFELAEAPYEIFITDKKMSFLNAKIAVRSAGAWFPGDKYSFTVIVEDTSLVRSDVPGKILTSMTAPASNHRFRLVSDDGDVTATAAHAWLAVTPRTGILYVTNSQRLREFNSSEAGVLLEASWEEDEKKGLAQRHLYRVEVHIQDYEEGRLCGQQLSETQCLASCGPGTVDGRCRWRHGSDTLHLSAHYSTCTGDPESCPDGICDELELMQPTLCPQDCAEHVVGEAVAGPTGKGIEKAMGICSCASAESCTCTKLPTKPASRDSVLVAHPWPPSAHEDRQRSYGQQPAISDLGRWPEPSGSAAPTAATSCGAGCVASLCLAGLLVSALAVAALVALVRRRRVAAKHKYLGSRASLSVPSDYVDSRSAASPPAPDAAVQASTPHAESAAGSPFSKLQANEQWEFPRENLILEQSLGEGEFGRVVLARARDIGGVRGFTTVAVKMLKGNWTPAEEQDLLSEFCMLKEVNHPNVIRLLGGCTTKGGPLYVIVEYAQLGSLLNVLRRSRHMAGGGADVTVVCNPTYMAQEPSLGALEENAEDPVLPEIPSFSDLISFAYQIAKGMAYLADMKLVHRDLAARNILLAEGNVIKISDFGLSRDVYEGDTYLKKSRSYLELGGVQNRSYYNLNGGVPLMKPLLEDHSDDGEGSEAPEYGCMEFERRGPFAEAGVPEESNVHLLTKKNGFLVDSPVACWLARPDVLTRDGGSTESPKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8I2</accession>
    <name>A0A9D4T8I2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8I2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="136" mass="14791" checksum="74666E09B243CF6B" modified="2023-05-03" version="1">MLGLPRSIKSSASPFGPSRSSPPSAKTFLLRGGVPRLGHVWRIRGYVLGSWARAEAAADARQRAEVSDAGDPSSSQGTRPCVPLPPNHHLRRRCQHEYDISERGLACCSTPCRERRGSRRGISTVSCSAEQRAWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T934</accession>
    <name>A0A9D4T934_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T934"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="81" mass="8854" checksum="132B342A8DBD8E6C" modified="2023-05-03" version="1">MGHGSATPTQKPCTKRQRAQSAQTRPGDASPKHAERELAQGTQLAQSADAPPAHVEQYQSPGEHQKSEEAQPELVQQQVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T952</accession>
    <name>A0A9D4T952_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T952"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037131"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="261" mass="30144" checksum="43A0721033C35850" modified="2023-05-03" version="1">MRILVDASQSACGAAPPSRNSFTQRLGALLLDRTPARSDGQGSGNPRDEARLLNNLLKLMYDWIDSNREFLFVKEPQEVGVYKNIMRDACVKVSRSLSRDMQPHKLVILCLRFACAWCLKIFQGGSDGEVISRECRRRYRLGHLALITLNRLSMSGNLAYLRRAPEGNVSTELVRIYIDRADEEFFTIIRRYEDIFTVIMTDWSGVDTIQCHIKTDRMDEWFLQLMVTGSRWALERLKDIVVYPSFREVLSLVFKRQISQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAU9</accession>
    <name>A0A9D4TAU9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047868"/>
    <dbReference type="OMA" id="HVHFVHE"/>
    <dbReference type="OrthoDB" id="6497189at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="556" mass="61851" checksum="4661CA0E48D052A0" modified="2023-05-03" version="1">MSSYELPANASEDVLRRKIAEVRGKLHSLNISNCIVAVPAFLLSLASDLRNLQTLSCIACPLKASLLLDRLLTSLQTVTQLDFSLVDAMDDAKEELVKIRHLGIVHGGKETKISKMYVEVADKHNMKVLLLFLNYCPLLRDLHVHFVHELSSDLCAATCSSIADHLFNLVTFTVTCEAPSTAKSDPRQPIDLRYCIDLHGNAVFRKRPLAFNCAQLRNLVLSPKPTFPLEPVVLVAVDRPDLGFFVGVLLHNWSQLRSLCVLLYARNLDQAVYPTISTLHRAALRNFFATLLNLVELNVSSFHFGDGVDFTELLAAPALQRLRALSLPPCGLRPEGAVRRLALGLGDVEDLDIRLNLDGRHKSCPSCAKELTIEPADASAFCIGSGRLTLSNVPNLVSVNFLPHFKMPHLRFIDGSDVPRFDYRALSRALRSSKTLRSLVIRMALINFNELSFVTLLRPASALERLCLLTKTKLQASKAEMVVQAMARQLPSIFYIHIHYVDIETDSETTVTWIRRPEGEAARPSSRPSVMPGKPCIMCSTQTFVALAKPLYRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBA6</accession>
    <name>A0A9D4TBA6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_018836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBA6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036323"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="10">
        <location>
            <begin position="159"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7984271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="536" mass="61352" checksum="FE4D53A2CE3D90A8" modified="2023-05-03" version="1">MQAKCSDLDGDEYSVIWYPPLIFHKNDDPMDFYDDAAVENEGPVQVEDMVDFLCKYIQHDVVGLISNAHLAWADWLREGVKSNMCQTLARKVSRAVDFAKLGRPENLSMSEKPAAYPDFMQKHCEKDTYLSRSALGKLYRKLGGMVLESVGPVADVQPDSRLIVEGHEEHMEVARQALARYRLRIRSLLATYGITSEIEALSGAVMTMDPRISEKHDHTDVAVVVEYQVKHIMARARDEFLEGLGTDYREAKRRASAWYCCAYEQGAQAEGFAWCVASELLDILQCAAPTDGPTRGSIRDRVTHALIPREDQADVPFKTALFNNALRLLKRWLRGNKEFLWNTDGDAAAHYLKHVARVLQKTLEQLETNFGLARIRKQPSLVLVNILKNLVLCVNPKSGKMEFALADLAERTLFRLLYPGEAVEEDIPLESVTPVGPTQTQVVLLPMRDDDDFFLAIERQENRFRGLLRKWMQLQKVAIMIWQDARGDWFFKLMVTGSPWALDRLKQTIIHERFHDELKKILLEHDDKDVVEEKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD28</accession>
    <name>A0A9D4TD28_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_025423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010000737">
        <property type="protein sequence ID" value="KAH7985748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD28"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054583"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7985748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35937" checksum="986254E5CFD1C70C" modified="2023-05-03" version="1">MGKKSKGPRKKHDAKPRKKKQAEEAAHSFLEDESEEEDFDTMKLDAAAAANKKKSGGFQAMGLSHAILKGILKRGYKQPTPIQRKAIPVVLEGRDVVAMARTGSGKTAAFLVPILERLGGRSPHTGPRALILSPTRELALQTHKFAKELGKFTDLRSTVILGGDSMEDQFEAIHENPDLLIATPGRFLHVVMEMNLRLNSVKYVVFDEADRLFEMGFQEQLTEVLHRLPEGRQTLLFSATLPRLLVDFARAGLSEPVLIRLDVEDKLSEQLKTVYVMCRNNDKTAILLYLLKHVIKPDELTFIFVATRHHAEYLRDVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE06</accession>
    <name>A0A9D4TE06_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000254">
        <property type="protein sequence ID" value="KAH7986829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028393"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031711"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22115" checksum="C30686ADE814D108" modified="2023-05-03" version="1">MAEAWRQLRPLAIANSFAHAGFSRVSESIEEDIGADFSGCDELCNEVRKATGCVSDTEDGEIAFEEYALYEADVPVTGMLSDTDIIEMALSSKQQILWSLQELLLSQNSHKVSLATELGLPQAVTPSGGKPRSTAKKWPNKMPWIVLTEAVCVSRTMYVIDQFACEVKDPLVVAHWACLSSPTHNSVKINILSQGYETMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE63</accession>
    <name>A0A9D4TE63_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000216">
        <property type="protein sequence ID" value="KAH7986938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE63"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050014"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="369" mass="41204" checksum="DD367547B0565775" modified="2023-05-03" version="1">MTEALHEAETKAREEAAHRASAEELSKAAAEEVVEVRRLARNAEESLHEVESRLKAVHEELQICREKLVAIEQSRQAAMTSVEAKEEELSRLQQALKSAEEQQKKRPPMRTASAAHGAQHGPPGVPQEPLGQRLSRWHRPSYRMAMLTSRLHAAPHVAQRNRLHPQMTHWRRMKHRAVLADDNAEASPLKRLGNFVAGMLSMARPIGVDINASITNRSNWSNQIKQRRRLSPAVAAVLTTFPVAVVWSCEIEIVLCEKLPVDTAVTCEDYVDSDCAAATSAELTCKEIITATPILLTHLTHEDDAGDAESGTTEETISSSDVVVFLEKTRSYLGCCKDVPEDILRKVADVEAYMHQHLLSTRQMKIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE99</accession>
    <name>A0A9D4TE99_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM214A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000053">
        <property type="protein sequence ID" value="KAH7987823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE99"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043802"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7987823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62357" checksum="94A7B89DD873C25E" modified="2023-05-03" version="1">MRPAVEEVVIDPYDFFIDVGSLVLEGRCQRYEVALKHMLMLWRNSIPMAVEVLLSPDCAQCSSTDHTSGIDTSSAPDTSHLLLEQWYIQMLPRRVSEATAPARCLLQAMRSYLYFSQISAWYSLSGGRSPRSIYYRISVPGEAFSSKFLCSPHVHNFPVANLGRNTYLKVSVKSAPRCPNGIPAIACAKHPSVPPMSTTPTEPLGPTITATLQSRSNRDVNNDGLIRNDESVAKRKPKKHSKGDLSADVLLGESLLDPPQSLQMYPKRYQSPSRCGSPSVEAPEHLLFGSRAQSPLEPSGEAETEHKRGRAPRRPVIERFLKKSGEPLPGDVFAPDAPTASSNRVQPRKEEIAPTPFWPNQQHSRVRSLMVPLQAPEQQASFVPATPQSPLLLSNERVIASVEELGENKLPDKFARAASPDQCGLKQSFEDMSLCHIGKPSAKHKLISSSSSSVLHEQPPAAKPHFQRTSEPNVQSQCVASTVTDDKVEHRTVAKVVKASGSRCDGGVAAHKEEANHTKRGLGHSKTWSEGLCDLKLKDGVVGKGSHIFNNLIHKHKVRQVSKPQMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQ70</accession>
    <name>A0A9D4YQ70_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQ70"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040996"/>
    <dbReference type="OMA" id="HIVCCAY"/>
    <dbReference type="OrthoDB" id="6494906at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038514778" description="Secreted protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15900" checksum="57DA74D0A0572C9A" modified="2023-05-03" version="1">MARPIRILSCRHLLLATGLVLLAAAGVSIACHDLDFFRNRQECSHTFENEFRRSYDEYHNDHARSREIVCCALMRANECIRSLYKRKQCTDSGIEILAHYARKASAKDCESFDYRPCGAGACTISASALLLAALVALVVKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PA76</accession>
    <name>A0A9D4PA76_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_025290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001967">
        <property type="protein sequence ID" value="KAH7931795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PA76"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027204"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7931795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22564" checksum="447EDE3F41199A97" modified="2023-05-03" version="1">MIVSHLSDFLYQKLGLGNDEEPVHILDEPSIDGIVRYIKSGKCKNIIAMIGAGISTAAGIPDFRSPNSGIYSKLGKFNLPSPEAIFEIGYFRPTLSHYFLRLLHQKGLLLRLYTQNIDCLERLAGIPAESIVEAHGTFHTSHCLSCNREYSLDWLRDIVFFGERLPSRFFDLSEEDFARCDLLLIVGTSLQVQPFAGLVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAL1</accession>
    <name>A0A9D4PAL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030326"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29050" checksum="ADE795FDAB92BCD4" modified="2023-05-03" version="1">MESVVSGISMVVEDTVNTKGDDSDAKKTIVAVCAICCLLLLIGLIVFLLAGSDDLEEVEEDDVLKAGQYPSRRGGPSRPAASYENNYAKARNACTIPCDKDSYDPNLRQAYANSALTNPTFYLFAVSVNELICTVGASAIRENMIPRDALCTYVYYTNVVVNRGNLHAVEDSRSWEAFKNALANLKNTTGGIGFDVRNVTVSDLDATLVDKSLKDLASRRVKHYGVLNVLDTVTQVKAVFSKAKGLLRVSDSVPVVAYTTMSSEAAVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAY0</accession>
    <name>A0A9D4PAY0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001429">
        <property type="protein sequence ID" value="KAH7932467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAY0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035954"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7932467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12267" checksum="FD39536CC221DC3D" modified="2023-05-03" version="1">MAAPTALALQAASSNAQLTRTLERLLEEAQHTGDLKLNGRKLKELPSYAAKYDLRDIVHADLSKNRLSELPTELCGLVLLERLDCHSNVLRVVPACVAALQALTYLDLSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBJ6</accession>
    <name>A0A9D4PBJ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_001969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBJ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048120"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="94"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7934897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="496" mass="54237" checksum="1238BF8C91C32C08" modified="2023-05-03" version="1">MSWVKPDDGFFLEPPPNQSARKRVTRKRPAPKDIEGSADPATSDPVEALARTSGGTWVEKFAPKSRDDLAVNRDKVDQVSRCLKEKLKASATNAGAIILLCGPAGSGKTATLRCLAAEEGFSVCEWINPVSLTAKTEFNPNWDFGRSSGQVEEFEDFIFQSSRYASLLTGDSAKRVVLVEDLPNIFIRDVESLHRVLRMCDRVAVAPLVFIISDSSDKLEHRLFPEALIKELDVTKITFNAIATTFVTKALCTLLDKAVQLQAITHEPTADDIDSIVAASNGDIRSAINALEFFCSPQQCVGPVKSKPAAKRQWSGACRKRRKKAAKPDARSCGIGRDVPLTLFHSLGKILHCKRKQQDCTKTDGGTEASAGDLSLSSMKDPDKTPSTDINPEEVFERAAISGEAFALFLHHNMPDFAADIHTVAECSEWFCHSDVLLSEWTSENVMEKHAMSVVTRGVISSLSHLGTKGVGWKPLSKPQWSAAFRDVSTGDYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBX4</accession>
    <name>A0A9D4PBX4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036312"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="250" mass="27759" checksum="DECF3FDDBA692D1C" modified="2023-05-03" version="1">MASSTVDAGPVNPRRKALFAAVCSICVETGFSSAERAAVESLVEMLQSCLIEIARSSRAFCELSGRTEVLSGDVFVALIEMGINVESLWGFVKRPNRITLPTPGLQARSSTPKILQAGDKKPLPPHIPEHMVPFPDPHAYIRTPTHKQPVTEYEAIREKLASQKRDVERALTRFVAKTGPTQSLFADQSAPFPLIACKPMAQPYLAALLPKDQVFEQQEEEQSKSSPERPPELVDNPYLRSVKMPRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR2</accession>
    <name>A0A9D4PDR2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9502" checksum="D127956A5210D5C6" modified="2023-05-03" version="1">MAAKSDTLVPSQSKNIHIAELLIEMVRNYLVLYDKRHPKHKDSLLKDDLWNKIGNELGLTGPAGNGADSSGARCQAKWDEASVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF12</accession>
    <name>A0A9D4PF12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041321"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="194"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7936400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="365" mass="41236" checksum="4909E40FFC39591D" modified="2023-05-03" version="1">MPPSDVLSNARLLSVLTWAEIDDLLLSHKERRLLRHEYTLDELEDEMRRSREAELVRYRSQHGLLDIDRMDSSTFKLMFRFHKNDFDDLCSALLVPQEITTAQKVRLCGREALCVLLRRLAYPNSWCDLEGIFGRHSSVMSNAMSRLIGHILSTFGHLLTDVNNHEWMSLASLKEFTGAAEDKGSPLPNCWAFIDGTARPICRPKRNQKLYFSGHKRMDMVKYQSLMCPNGIVCQLDGHYPGSWHDARIFRESGVYTKLEKLTRNEDFVVYGDPAYPLRPLLMKPYGGSCLSPAQQAFNCGMSAVRQAVEWGFASASPPEAMEVTPGSSASLTLTASPKVRRSSLDRLKGKKHPPVQPPHKGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFB6</accession>
    <name>A0A9D4PFB6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFB6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22341" checksum="A021529B1230FD02" modified="2023-05-03" version="1">MASALNAVSYTIVYDYALRGLIDRTHSVHVAPGEDHQPTSLLFDRHAEEFPQIFLGMPRKTKTRPKYHDSVPSGGEADVVCARMCRAVSTRKTTAARKAPPRGRVARSFGSARAEWTAEPPLDDQSRRAGAGFLNVPLPRCSRRAEVGLPRRTAGAQGHNSLPPEHVCRRLQFVDGGAEPPEFDVATLRLLTSSLQQRRLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFY5</accession>
    <name>A0A9D4PFY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034584"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="410"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="690" mass="78269" checksum="2BADF25E7692593F" modified="2023-05-03" version="1">MAAPIKMAGDVRSSDARHWKRQKESLPRPKIFKKTNAKFHNNASKPAFAGETSDTVKFNQILVKPNKKWYEQLPEEGSAVTVADNPPELVSAKRKLAETLFEHDKELYRKHSESRARASDMRWVRTVLAKGALADKVAAHTLLIQESPLHNLASLDSLLAMVTPKGKKECLLAMDALRDLFLSDLLVPDKKLKSFCQRPLASLSGSGLVESRTLLLWYLEDLLKQRYATFLQSVETVSFDQVEKLKLRAVTCMFHMLTYHPERELFLLERLINKLGDRTHAVASRVAHHLTQLTNHHPRMKGAVLTEVDRFVYRPNVASKAQYYALCFLSQLLLSDNDVSLARSLVSFYFTFFKKCVQRSKVADARTMKVLLTGVNRAFPYARASDAEGLPDDQTNLMFRLVHLTDFNIAVQALTLLFQILDAKSSLSDRFYGALYRKALDPALEHSSHQTMFLNLLYKSLKRDTENNRVKAFLKRLLQACLYRSPHLACGILFLVSEVVKLRPTLLDARTFDDSPDDEAPECSVQLDDNDSDGEHYDDAPDDSALDDPSARWQGEGRARVWLKVAFIDNDRPPRLRPANPHRFVFQRAFPLKKESARCSPSAEPPALAITADGRNPISRFGHRFCTSVAAATWPGPRHPPDHFENPLRWFASPTQTLWAIFRGTRHSSRAISLDDSLWRRRHGSASTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGI7</accession>
    <name>A0A9D4PGI7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGI7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042083"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="1">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="208" mass="23708" checksum="CC3F81D795125C1D" modified="2023-05-03" version="1">MSRDMSTPEHGVCLQKKRELTEQMEIKMDTGLDRSLAAIIGWVHCILQTEQKKTDFKPEVEDVIETTKVAQKVVKYVTKCIEKLRDSLDGTNVDAVLLELGVRFHRTIYEHIQTFQYSTVGGMILICDHNEYRKCAKLFKIPALDKMFDVLHALCNLLVVAPENLKDVCRDDQLASLERGVLVNFVQLRTDCKVHKLVNQFKLSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHK1</accession>
    <name>A0A9D4PHK1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_017263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHK1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7939770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="290" mass="32333" checksum="EC23CD6703546145" modified="2023-05-03" version="1">MELARDTFSFETMTTDEEGVKCSVPTCDNVDVEGCGIVFHRFPISRPVILKKWLIQLQREDWTPTIEDRICNDHFDLRWFSEKNGEKVLRWQATPTIDVPGPRDCGEGVPQRSYLDRPKLSQELSDPDEPEATPCRSYVRKKKRPHESVQVTPDAKRPPSPIGLVMRKPIDSLQDIVNGLRDGGDSEDIGAAANEGAAGDQDLASWDALLDAGVVLDCDTFCTYVSADADAVTTEELTVTGVVNDDSDECVDDIPELVNPMFRRPRKRWMRQTRCAASSALTMTARTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIZ4</accession>
    <name>A0A9D4PIZ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052851"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="62" mass="7125" checksum="DADC269F9E790E2C" modified="2023-05-03" version="1">MGDDGGGGGDEQLSEQFTSGFRLRARKGALKKKNVFEVKDHKFIPRFFKQPTFCSHCKDFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJB9</accession>
    <name>A0A9D4PJB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_017641</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042142"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7944251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64400" checksum="C60590AF195CD41F" modified="2023-05-03" version="1">MFELESASGVCFCGRLDLLAAIGRWLISERKKCFDAFEGTGVPTPPLRSLINGNTDEFLKPSQIESLGRWLKEYGDVFGFYLGDVPFVVVKDPEMISEIFAKEFNNFHSRGHLLRIHELEPILERNLVLVEGRHWKTMRTCMQQFFTPAKLKVVMPALLDAQREFLNILGEGADSGVEVDIGSRCERFTFDVISKSGFNLDTQVQRSPDNPLFQKALRCFPGIMSGFMYSLALNLYHWPRVFKMLHKLFGYFFTNPLVEMTKYAAEIIKYRHQNPQVDVPDMAQLLLDDALGKSNSETKKNEVPQTNGVPLSQEKLYELSTNCMDVFLGGYDTARLALTYWFYLMGKHPDIQERMRSEVLEAFKKEGDELSVPTLTGLTYTNQVLSETLRMYPPIITFTTRCAGEDYRYGKYLIKKGTSVMVPTYQLHHDPLYWTDPEKFDPDRFGPENKHLIKPGVYQPFGLGIRVCIGQRLALLEMASVTSQPDLELITYAFLLAPKDKVWVQLHKLEGLDAAPLGGADELAVSGRLGCREVVGTSGRHKGVSPDGSIGDRAGKPSGGTVLRTQLGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJE6</accession>
    <name>A0A9D4PJE6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJE6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050882"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057517"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09120">
        <property type="entry name" value="PLDc_DNaseII_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF23">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038823397" evidence="3">
        <location>
            <begin position="23"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="606" mass="65629" checksum="E10754FFAF93C572" modified="2023-05-03" version="1">MAPTMSYVLLVFGVALLPAVNGQCINVTLPNILNLGECLGTTLRACPDTSSGLIPDLTRVLGCVLQILPQIGSPVSVLYNVVGLLEAVVSRLGLSADIGGLSDILCNPLGIPLFSCGTFSPGNIACREPLQISLPSVFNIGACLNRTLLFCEEGSTISDPILRELFQAVGCILSVAPEGLQLDLVSSLVCPLVDILNSSLDEFTSLLPFRFLTRGITSAVRSLTNNLLGAVGNSALFAQGIALVSCAAVPSSPRCKDQNGQDVDWFIIYKLPRMQTYDQNSFTPEGGEFVYVDSRSTQEPLRYWPLSAQDLYKPQNPVALTLAPLYENTTRKDILYFVYNDQPPPMYNGTRNGHCKGVVLFDDNVGVWLLHSVPGFAQGLQSGQYSFPDTARENGQAFMCVTFPTPQVDTIARLLRTEYANVYARQVPQAMKDKYPEVALLAKDSFVRALDQKLYIANLTSVGGVALRAYAKRATLDDDLYSGVLANDLKDDLAVQSWRNGAGGKLPPACNSSYTVVNIDAVLLRFDANTSITFNTTEDHSKWAVTIDRDVFCFASMNRMESVPASHPGYIGDLKKPVAEKSLCFSNGVVQALFARSAIINEGCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLH0</accession>
    <name>A0A9D4PLH0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_008493</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLH0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046185"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000035">
        <property type="entry name" value="Kinesin-like protein KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="550"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7947227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="899" mass="99042" checksum="E855D11E0EF417A7" modified="2023-05-03" version="1">MATKKLGNQHIQVFVRCRPPNAMEKRNGFVRAVEVVPEKKEILVNDRVIPERTLRKSFTFDKVFGPDAKQIDVYRAVMEPTIAEVMMGYNCTVFAYGQTGTGKTFTMEGDRSNVNLGWADDPLAGIIPRTLQQLFEELQSQDLEFTIKVSFLELYNEELFDLLSAHEDTSRMKIYEDSSRKGSVIIQGLEEITVHNREEVFFILQKGAAKRQTAATLLNATSSRSHTVFSVTVHIRETTDDGEELVKTGKLNLVDLAGSENIGRSGAIDRRARNINQSLLTLGRVITALVDKAPHVPYRESKLTRLLQDSLGGRTKTSIIATISPDMTNLDETLSTLDYAHRAKNITNRPEEYTEEIERLRRDLAATRDKNGVFVDQENYRFSDVKYLINRFPVLLPLQEGQDVNSALDDIQAEFTRLQLEELPAELVGVAKTTTNDIDLLQQKLQRTSAIDQANKERQSAFVSSSSALFGQIEASFTERLASQRDVLSGVGGSLASLGSLVQQHQAAVAAYTLEAKKFADESAAAGTSLLSSLLSTVQASQEQQAAQMVANLTNNQERLQKLCQSLVAERMQAAQKKLQELEKHHLALGEQVSSVCHLVSDEVAAHYKQQVHLVSSILEENDKLRRELDTSNEEIQRLSAAMEAKSTEAKKDMAVFKQQFEKFSQSFFAMEAEQQDTMAKMTGLSATVARTGIAVTSAVKNNAESLVKSSDDLVSSVAALHQNGAKTTKDCLARAQEASRDLSNIHKVVEERFSDEVTSTCECLAEQKRAVDDQMAACASAVSEAVGAGTDVVRGQADKAKALAGDLDATVSNSCDKLLSTCHHGTVQTAQAQDISEALRAGIANDMAKCSSVVSDFFQHDLQEYVPTDWPDSTTGQICSIFFWIIDRVSGIQSSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLH3</accession>
    <name>A0A9D4PLH3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLH3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051167"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="278"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7943881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="621" mass="65854" checksum="73A4558EF9690327" modified="2023-05-03" version="1">MSIPNICRRKFQGPQSEQQEAVAMRDQHRRHAYFSRTAAARACLDPFVPIFLRHHGLTALQAGFVLSAAAHLLRSFRSSRLWIPRYCLASSVARLCATVPAGDTPTRRPGGDWVSPCRVTSELARGKHTDVDSTDGSIALIQGGHWYAQGEAKSSSGKPFPAPSPTYELLPTAVPLDAGPATSVVARRNGRQRTCPTKKATLVGVAMRVQGTASPEVAKNASKDVPSHSLDGVVIPVKDKKGMPSVPAANPDCQGDRTSPDCPAGPTDHRFVMDNAALLLLAAAVVLGSSTFALAKFVADESYFAFLDEIDATEKSRSHETYAAVVTALVLGAVAILASQTPCLPLPTWGFRRSTWRPSVRSCSPPCRWPPSFPSLTSLCVARRPPGRCRGVGSVLKNVEGALIVGGLVFLGLLAGLEQAFFMWHLEETGKKVELGVVLMARAVSNVASLFLLCAGGLPSRLLAWLAFGIVCVAARCACYVQSGWELAAVAQLLSPPSTVLVWVACERWARRSSTRLSTERGLLVVMRCCHNGLGFCVGALAGGGIAAWLGVRTTLGVGAVVGIISGLAMLAASRFVAGRPPSYDRLLWDPTSANSDSESEEEPKMAGDAGVPVTVTPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM24</accession>
    <name>A0A9D4PM24_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM24"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10628" checksum="AB24EA1F1F7848C8" modified="2023-05-03" version="1">MEPRFAGFYAEKRKTKRNTSKTASNRLVSEKHVQEEATNARSRLSTQRPLRLMLFGEGFSLRPPENHGKLRLTKQSTFSTPWKSRRQPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM27</accession>
    <name>A0A9D4PM27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_011665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056129"/>
    <dbReference type="OMA" id="RFMKEDM"/>
    <dbReference type="OrthoDB" id="6507093at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57501" checksum="9D9C7B35FD350A0A" modified="2023-05-03" version="1">MQGVLWKCLSTGLVAGFGALLLQYLWAVLKRWLRKDLPPGPFGLPLLGCLLFMPKDHRGVEVFRQKYGNVFGLHLGSRYVVFLCDFGSVKEAFLQDALLNRPEEFPFKVHEQSQGLILINGPLWRLQRRFSLKVFKNLGVTTPAMETHIREELSYLIRELQSLERKPVVPTTLLTPSTSNIISALVFGRRFEYDDPERSYLDQLIEVIPALAAQAAAINFFPWLRKLFVFFRVGACERLRDALARREDFADSKINEHEDTYKEGLVRDYIDGFLSEMKEQHNECFTRNLLKGNVSTFFGAGSETVRSSIEWLLLMCAVKPELQHRIHAEIDAVLQRNQSSHILWSDRNRMPYTQAFIWETMRYKPVVPLNIMRYADADVKAGGYVIPRGSIVIASIWSIFHDKSFWGDPEVFRPERFLVDGETRPLKPEQFIPFSYGKRSCPGEVIANMEEFIYFTTILQHFAIEAPPDSPPLVFDEIPGLSLRPKPQELVFRPRLVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM74</accession>
    <name>A0A9D4PM74_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM74"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051755"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10119" checksum="31F89D5A611B2283" modified="2023-05-03" version="1">MKEKSKNAARHRREKENAEFGELGQLLPLPAAITSQLDKASVIRLTSSYLKMRDLFPDDSCGAVEVTPVMGSTLLHSPAGTVNAERIASRIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMZ9</accession>
    <name>A0A9D4PMZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_007494</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with melt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027537"/>
    <dbReference type="OMA" id="DRHDTAP"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010883">
        <property type="term" value="P:regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16676">
        <property type="entry name" value="FOXO-TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="17">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="15">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7947063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="35191" checksum="730BFF739A14A2A3" modified="2023-05-03" version="1">MDRLADVEPGFEPQTRARSNTWPLPRPENYGGDEKAGAQESPFGEAGAPKKNSSRRNAWGNMSYADLITQAIQSAPEKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGAGKSSWWMLNPDAKPGKAARRRATSMETPRYEKKRGRLKKKLEALRASPSPSSSEGPLDPFPESPPASRLDLQHCSPLAPLSGSPSAWPPQQLMPVDRYGAGPLADTLTQSMTLGDRHDTAPPPPMGPSASQVMGRLLTFNDHLPNDLDLDLDAVPGLHCDVDQVIQHELSVDGNLDFNFDTHARPWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNJ9</accession>
    <name>A0A9D4PNJ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNJ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="273" mass="29577" checksum="08DC5B3A487A6DE0" modified="2023-05-03" version="1">MSSSESILSDQPQAHLLTSRQSFAECVASASLKESMAAEDTFIEHLPVLSGSARRGMAEGIDAPPEDGASIGPSGRLVCDSADDNGQFILTASAQHECRTDHHKAVCVYGGPYAHRSDGRGTETPESIFAPCSYGTGECGDGRAEATAPNHEGQVSQHDRTRKHASLGKYVPAQSADMDKHGLERSTEQRRRNLMVQLERAICGYGEDMSVLPDGYFDVVLMTYVLCSAKNGRNVLDECKRVLAKLECFGVTFRRVEDLLHPVVYVLGGRVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNV7</accession>
    <name>A0A9D4PNV7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026547"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="613" mass="68374" checksum="6393CFE5FBADC292" modified="2023-05-03" version="1">MEVRPNVTVAPMRRPTNQRCGFSFYTYCTKLRHEAYYRHSTHSCVLTITDDVQVCNHSPNKFATLGECQRSCVHTRMPSVACLEKPLFSWCGRHHVNASWWVFDGRNCRPWNFPAGVSTCCAGQRKGKSALPTIRPIGTAPAISEIPITEFRCSNQEFPGYFADVETDCQVYHNCLADGRNSSFLCVNGTIFNQRNFVCDWWYKFDCRKAPSFYHLNLLRNKKNGTKAASTEGALPAAPKVLLPAPPPPRQQPSSKRYLEKEARTKPSSSLTSRYSKPSSKPPSPKTPARTPAKASPKTHESLILLPFANIDSRHTKQTTTTAATTRERSSRGRAQMRVFAKIKDGQEPAPRTPKSKTRTKTAKVEVPEHVMSSFSGDADRHQNGGGFQEWTSIGAVSGRPSVTRVQFHTFSANPPRFDPPLPQPAPQPAPVVDPASWLDDDFNREPDAGVEDFRGEVEDGRSQEEQAPEGGTSTTPQPEVKRQKSKSSADDVVRLAKALPSTRRQTANGGWRGKKEAFPGLQDKKRLFYRFQPSEPFGGYGALSYFGRMRGPMNDLSRLPRLVSVKLNKVERKEPEYAIKPLLLSVKLDQSSEVDYRTGKGAPPGLCFCPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNW0</accession>
    <name>A0A9D4PNW0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_009794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054513"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7947306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="20243" checksum="714585659D2D4643" modified="2023-05-03" version="1">MDEREVPGGSGDSDPGLQQANALLPVQLVPSRRGGFKAKHGGFTFNMETSKGSRRHWHCDVRGCKSRLTTDVYGSDHVVFKLTAHNEDVHQRAANERKRRRSEATYRQLPTTKIGDFTYILEDHIGDQYCWRCKYVQCKGKCRPIAMAAWYSDRRSTHACSWLTGRMVTNVCVRYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPY1</accession>
    <name>A0A9D4PPY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036449"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042803"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000416">
        <property type="entry name" value="Aralar1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000396">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="427"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7950927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="540" mass="59826" checksum="FF73AC59BB0849D0" modified="2023-05-03" version="1">MTSLFRTEAGANRVSPKICPMGGRNADCCFPFHIMATENAEVTLLEEKAGMEDYGLLSLLLSRASCEYASVEKDGSHYMTPNDFVRGFLGLYEGPKYNQQAVNMLGSILDTSKDGLISFMEFQAFEGVLCQPDALYKAAFQMFDTNGSGSITHDEFEDIIKKTTLYEKIPFDFKSDFMTLHFGADHARTVSYAEFSQLLHDFHEEHAIQAFKQYDKKRSGVIAAMDFNDIMVSVKSHLLSEDVKKNLVAVAGSASGGHQVTFPYFMAFNSLLNNMELVKKIYLNFTKGNSSLEVTKAAGATVVYPIDLVKTRMQNQRTGSYIGELMYRNSWDCASKVIRHEGLFGLYRGLLPQLVGVCPEKAIKLTVNDFVRDKLTSGKGEIQAWAEILAGGCGSRACFLRDIPFSAIYFPTYAHCKLKFADEMGHNGAGSLLLSAVIAGVPAAYLVTPADVIKTRLQVAARQGQTTYSGVLDACRKIWKEEGGQAFWKGGPARVFRSAPQFGFTLLTYEILQRLFYIDFGGSGMETKFGLLLPRYNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQY7</accession>
    <name>A0A9D4PQY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQY7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043348"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038789458" evidence="2">
        <location>
            <begin position="31"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7950779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="470" mass="50404" checksum="BD9F99050A3CBC62" modified="2023-05-03" version="1">MMNLKKCSSVRSTILQLLLAVSLLQLGTDPDPVRVNRRADPVRSVRIGVQSAFTHTHSLTPPLLIHPKSVDAFDANPVFAELHELGIPSLLRRVRTRVFAYLAEDPGPPPPISNEVAAASESDSPSDASGASSNLTQEEMDLIEILWKQDEDLGVSRDTFDYHAASESSSKEAVKPTNFNSTEVPEDEDEPPEMHEDSNPWEGFQYSIDSETGEHILGGQEESKSEEPRERVDSGCFLLDEEEDREAIFAELERIFQGQPLQAADLYPADDCWGGSEQRDLGADKGPPLATGGPPPHNYTDPFPGVLLNNATLGPPPVDHSSAYLHGAGAFGATACTGLPCNNGSSMSEGPTYGQDFPDYLYSPGTGMTGYGGMGNVTAASGMMPGMASMGNMSSNVTNSALACTPTDYLLNDLLADEDLHLMDMVASPTETDTFGLLDSFPDLCSPVPLRFLCESAQCDPVPLGQAFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSQ3</accession>
    <name>A0A9D4PSQ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_021446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSQ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028598"/>
    <dbReference type="OMA" id="LWQKNVP"/>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000042">
        <property type="entry name" value="Ubiquitin-fold modifier-conjugating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008716">
        <property type="entry name" value="DUF1782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR008716-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7952307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="19465" checksum="BE44A05DD3B215AC" modified="2023-05-03" version="1">MVDDATRKTLSGIPLLRTKAGPRDKDLWPSRLKEEYQALIKYVQNNKENDNDWFRLESNKDGTRWFGKCWYIHELLKYEFDVEFDIPVTYPTTAPEIALPSLDGKTAKMYRGGKICMTDHFKPLWARNVPKFGIAHAMALGLGPWLAVEIPDLIQKGVLKHKDDTQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT20</accession>
    <name>A0A9D4PT20_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT20"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="15446" checksum="E2D50FB78CC6376F" modified="2023-05-03" version="1">MITNERPTEAPAETYTKVDHDQPLDNDKGDLEEGDEETSPAFERTGNQLSVSRSGRHKQRLRRRSTIFENPTLGRSIGSKSPQQAAEDGGDQENGEPGEPEEEEEEDDHVYWILNQRNQNRQEPFHSDTLWVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTE4</accession>
    <name>A0A9D4PTE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028412"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="187"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="331" mass="37390" checksum="A6282877E93F196E" modified="2023-05-03" version="1">MSAPSAAIHGRGMWLNCSFDLESDELYSVKWYKNDTEFYRYIPRDRPPAQNYDLPGVVVDMSRSREGHVFISSVNLSSEGNYRCEASAEAPSFQTVVGEKEIKVFAAKLVWYINDQEVPFSDVRELETLYDSEGLQSSAVLLSFVLQPYHMIGSSLRLKCVSVISETFLTSSEELIVGDTVPSIPYPEASPHSPRIDGGLPKYRVNDLVNLTCRSAEYDRPPELRWFINDKEARPEYLVRYEVHRYPKYAASLGLRFRVRPEHFEEERMHLRCTVTLSNVLNTSSAEASIKNKHRTMSGFRAASKDATNGAASILAPLLSSLLVFIALSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTQ2</accession>
    <name>A0A9D4PTQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043517"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="178" mass="20106" checksum="4215DFAC2A526007" modified="2023-05-03" version="1">MEPSEVISERDPLLPNEPCVASIATPPRSLGKNKSGHILNSDSRNMIFHCYTYWCNREPERSVEDASKFVADMLGVGERTVLRMTCAKFDSFTLCALRSWAHDFFRRNEMPTVEKITGVLGALLAEIGFKREKRSRNSLLIGRDDITDWRNRFLRDSGVGNYDSAVGGRFAIFLATVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU36</accession>
    <name>A0A9D4PU36_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU36"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036787"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="885" mass="94745" checksum="B3EB3C289896DE83" modified="2023-05-03" version="1">MDEGVRVIAVNPSGQQSMGPSCQSSLTKVYCGPVETIGMPAPPKNKGSRLDWRITPEGGLEVTVGRPLTKEEEEKRERDRKSKAAGAATAAAPADAAAGAAAGAAPAAAPAAPADAAVPPAGIEKLKKQICDPLSLLANTRLPICFETTLGKETAPGLTSVTVINEQPGSPVMVQPRAAPVPSGRGFSPPECRANGFLADDTLPPPSPSSSNRRMRSCAQVLNDFYASRQMALRVAISAGRGESMCESVKRITAASAPAKTPDCPGTSLPASKIPAHKVSKPARTLLRPKSLGLKAQKRRNPHSEDAPGGRSRLGLTKHPRRPNTGAGATPATGDPNAPVPMMPTAFEMDTAPPLCVTDAIQPLSSQIPVLSQTPAATPSASEAQTSTQQVSQRSSLPKCGNARPPPQRLAKCTTIVVKFQGYVDITRLNFSAVCQGILYAVQATATEKEDTYIKRRDVQNLIVVQTFRATIAHRLLQCANIIVSGTTYPIRCYNAFDNTYSRGVIHGIYPDITEDTLRSELTIQGRTIANVRRLGTTNTVLVIVEGEELPRHARLFSGVYNIYPERRKAAQCSSCQELGHRADVCRNRRTFVRCPHCSKTLPPEQEASEQSHECEQYCFLCDQHDHSPTSPNCSRKTVNIPRCNPAAEDSANTPQYSQPSAGRRSLAVATKPSSAHVEIVSRHCRTLVCPAPSTKKPSSHQPKTPTTTSTQPKASPGHHGNHRMPQAQRGDPQEDITDPRNRLREQAPHHHIKSSGGTNTTAKSSTHQVICSSDGGYGGCQSPTVTTCSAMGGGGGNFTGVRIRADSSSSMGRRCEQLLPEPCPAMQALRIVDDVGTANRRTSSRVVHIFEEPPAPPRSTRGSSRDRQFSARVVHIEEDCPEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUR4</accession>
    <name>A0A9D4PUR4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_006695</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUR4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053743"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7956185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="480" mass="55092" checksum="06260FC1BFB20C52" modified="2023-05-03" version="1">MIGRTPINVDRSLASSEASARWYPYVFMVDEPGGGFQLKGITGSMIDYIITSMGIKYELVQPLDNAWGELRPNGAWTGMMGQLQRGEADLALGPFVLTEKEATVANPSPAYTDEDMVILSGVEKEHKSNVYGYIRAFDLQVWMVLLCFLLVAAGVAVVAEILLPDTRLSVRQRRQRVARIFWVYMASMFLESSTFHFASHSQRMLFGSWFLMLVILMNTFVGYMESALMLKEETDRLDTIEQLALNPKVRPIVFEAAGFLKIIEEAEGYAFEKVLATIKEFSEGQTEEAVHGEELFTPPYLLMVLNKEAAILMERISLLARVSQHCYDVELKGQGLFHLGRERILQIKMVFYVRKDLDQKLQVDRHLKTRALFPEGNSTAVPYCAMQDEIFRRVRWIMDTGLNLYWHEDLVPDPGPCWTRFHPDHLHDYQPLNFRDFAAIFYMLIVAQGCAWFGFVLEVLLYKWCCLKTRDDLNHDTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUT0</accession>
    <name>A0A9D4PUT0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUT0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7955619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33941" checksum="21569582D949A770" modified="2023-05-03" version="1">MSATAPSRATSHHEDTTAFIRSLPSPPETSGLCSSIASTMLRNPFCFIAQVTLRAQATVTHQRNPWYLARFRGRSALLSTAQLVASLALLTAPHFALLLWEASTGRRTPPLLGSATTALLCWSPCAHAYVYGVRSRALRQTFKDLLRRHVYRQQVCREAARRASAANGGTPGRPKLIRRFSAPDGLGSSSVVMSNARRALPRRASEKCMLLRTGSSGLSAAGSGGGAGAAMLCTTMPSSAPSSRRSLLMLEPATKPSSRASVFPLILEHGMSEEDERGPPGGCLRTDDEDDDMSRSRSPPSRATPDSTDTSASKLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVY1</accession>
    <name>A0A9D4PVY1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033771"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140560">
        <property type="term" value="F:xylosyl alpha-1,3-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="296" mass="32883" checksum="E868FACC3738F314" modified="2023-05-03" version="1">MHVVFVVPGCRSRRFAVNVTQLGDALDTLFQHASRPLHVDVLMAGRHPSNGDVVTLLECLRPSMRQGVSAVVDLFQLQPGKGKLKVMNITLRKSHRGTSNESQHRFLFPLCTSLHRLLRVDRVLLLAPEVRFHYDVSFLWAQFEQFPAEAVFGLAREQSPRYARTLKHRRGVAPKQGGCGDPPTVGGNPGLNGAVALLNLEGMRQSREYSRLYSEIDDIAEKYGWYGGPLADRDFYTMASCQLPALLHLLPCAWNRQVPARHKAPVASRDGAVRAGGLYRWCEGGVYACSAHCPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVZ2</accession>
    <name>A0A9D4PVZ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVZ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048690"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7956727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="306" mass="33843" checksum="C10DED7E22CCBC3A" modified="2023-05-03" version="1">MVDGRKQCQKCLEEYKKQRPAHTACLPPNKECTIKATHVSKAGIQLILRTHNHYRSMVAMGKLPKFSTATNMQQLLWDEELASVAQAKADQCTNANGKLDHDKAADRFTTKFKSVGQNLAFRRSSASFKGTDWPGQIKAWFDEYYHYPPDSVNSFSPPTEEPTGHFTQVVWATTGYVGCGYADYTVAGVKQMPYMQLYVCNYGTAGNVLTRPVYLVGPVCSACPKGTACVKETGLCSPPEATAAVDEERDTNSPGQRKKSKDGQIKPSTPYRKNDAGIIFTSSWNALFAVIAATYVTVFTWFTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX43</accession>
    <name>A0A9D4PX43_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX43"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035362"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35322" checksum="C4087A86364CC80E" modified="2023-05-03" version="1">MPSRHTSVTSFAKQPPFLEAFEQRFMARFARLEERVVAIDTRVAAIESHLSALDTRVAALEARQSATEATLAHLSLSAPLTPAPTPTPPGIVDWDRFRSIRLTNSSSSAITDLSAWTETLLADVRTATSTIPAAPHSSTADSRLLHLWEAYHAVHRRWQTQKHNRRLRLRLARLASEMEEHCSSFLRQQWGQTCDRMAGNLGLRDTWSLLRRKDISHLLHSSPLTDTEFLAALRDRYLCTDPPIPLPAYTASPNPDLDADISLGELISEEEKGELRKLTRDILTSIWKRHSEKPARTHNLLVVHAQKPRMPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXI4</accession>
    <name>A0A9D4PXI4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXI4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041421"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="20008" checksum="C279C52FF6EA171C" modified="2023-05-03" version="1">MVRSSILWDPYCLAYLSWEDIEALMLREKEPPRRRVYASRGGLLNLDSMSSHCFRRQFRFEKADFPVLVRALKMPQYITSAQGVRVTATEALCICLRRLAYPNRLCDLQEYFERHYSVVSSVSNKVLYHIEKNFGCLLSNMTIHPWLKHSDLEAMSEAFFGTASCMKSWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXI8</accession>
    <name>A0A9D4PXI8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SBNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046823"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000282">
        <property type="entry name" value="Strawberry notch homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="7">
        <location>
            <begin position="168"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="6">
        <location>
            <begin position="825"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="657"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1346" mass="148257" checksum="5AA23E17E8E73EE4" modified="2023-05-03" version="1">METPDLLSAALDASGIGEEEMANNHAQDSHQNLSRYQIPPHLMNYLPPHMIQQMAHHMAQQMAQAMGQQVPFPQAGPGGKFAPGMGPPGPGMDKGSGAPYYMVPPFGFKAGNGGTPPYPIFRPPFGMGPGAMPAQPQQTGEDAEEEEELGLAETYAEYTPSKLKIGERHPDPVVETSSLSSVQPPAVWYNLSIPEEVIDRALLSALQLEAIVYASQQHEVLLPDGSRAGFLIGDGAGVGKGRTIAGIIYENYLLGRKRAIWVSVSNDLKYDSERDLRDIGAGKIEVHSLNKFKYAKISSKVNGSVKKGVIFSTYSSLIGESQGGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLTVLELQNKLPKARVVYASATGASEPKNMAYMTRLGIWGEGTPFREFSDFISAVEKRGVGAMELVAMDMKLRGMYMARQLSFAGVSFKIDEIPLAKQFIAMYNESVKLWVDARAMFQEAAELMEGDSRIKKTMWGQFWASHQRFFKYLCIASKVPHVVSLAREAVKNDKCVVIGLQSTGEARTLEQLEEQGGELSDFVSTAKGVLQTLIEKHFPAPNRKKSLRLLGLGGIVDDPIPSPPPSSSTGGHKRKSARQARQGVKRYREASSGDDDDSDVEVKSEPESDFEPSVSSSAAEDSEGSSAVESDAEDDFNPFGDDSDSDEPSHAVARVRSLRSLAEVADKPEILSSVFSGCCARSALVKNVVLILLPRFLSLTSSRRPPTQISRIVSANTLAVNEFSPFAINNSVAAVLFGSAGAAPQPVVRNVPTVDSEKKAAAMKQELLERLENLGDKLPPNTLDQLIDELGGPENVAEMTGRKGRVVSTDNGTIQYESRSEVDVPLETLNLTEKQRFMDGEKHIAIISEAASSGISLQSDRRAKNQARRVHITLELPWSADRAVQQFGRTHRSNQVNAPEYIFLISDLAGERRFASIVAKRLESLGALTHGDRRAGESRDLSRFNIDNKYGRAALETMMRGLMEMEIPPLVPPPEDYEGDFFADCRKALVGVGLVNEDEFSKMQTLDKDYNNMSKFLNRILGIEVELQNAMFKYFTDTLDAIISEAKKTGRYDLGILDLGTAGDNVKRVKVDEFIRNHATGSAKTELHTVSVERGLSFEASQDIWKELTSKDEGYYLSNQVRCGKKTAVLAVADQARRSKEKKEKLFRLYRPNTGLQVRQESLNELKSKYKKAMLLCLTCMQVTPDEAQPHWQEQYESSENTCSHIYWYNSCRKKTMGMVCEIGLRRRTYHVLSGSVLAVWAKVESVLSSVHGHHNSSKLQVVRLKTEDNLRIVGTIIPSNCVAPLVNVLSQDAEKTNSETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYF4</accession>
    <name>A0A9D4PYF4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043084"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="515" mass="57214" checksum="89D3E11FA5A80EB8" modified="2023-05-03" version="1">MFLTATLPIDLGSSTHLIQLLSNIEWIPDFCGEVKFSLIGVFHPVPRRRSARQAERDASRMPLEEMAFGEEISRQEDEASGWIVARSRKKQRQDFTPGYSSAGNSSARPAHPKGPINKLIAASRLPRLPKDHCRVVVRPQGGMGVRKVTRIKVTQALVTAACLSPPQAEENIVCANEMQNIFVISTPHVRHAEAYAKMKRIRVGETLHEVSTYVTPPGDTCRGVVRGIDPELSDDRLGELFVHARTPKVLGVRRIKQTPTVIVLFDGMKVPNYVMCGTNMIRCTLYRRQIDACRTSGKLRHRLDVCPTPTVITCPDCGVSSPLENHTCHPKCSICGGAHPTRRIGPAKAGTRRQRRRKTNKQRAEFVPQQAAGLGLNQGGGLDTPGRGAGHRSRSRDRSASCVRTQQEPTWAERVGPKQQATARIQQQERENATLRIQLQDIKEEVEELRQRERTPEGALKVQQAEEQPKDGKRKATDPPVDIEDFSDFKQETTGVVREIKEAIAGVSSVIESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZR3</accession>
    <name>A0A9D4PZR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxinectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049439"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF134">
        <property type="entry name" value="LD42267P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7957363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69164" checksum="D79B227F8C2D681E" modified="2023-05-03" version="1">MVVPVRPGHGRPRKLDKEQKRLLPVRCNPNARYRTHDGSCNNLRYPCWGRAGESYGRLLKPDYGNGMWTSRKGAYGRKLPNPRLVSMALSGTSWQSSDTEYSYHSDLIVHFGQLLAHDLTSSATFTTAQVVDGKVTKAPPKCCGKGVKPHPECCHITMDHKDEFYPMGHCMDMVRSSAYNSSRTACPRNSPGDYREQINEVTSFLDGSVVYGSSEEESKKLRSDDGKGAKMKVDKSSLYIPKGLLPRKSEGDCNSYMPGCDKQCFMAGDQRASLTPVIASLQTLLVREHNHIADELKKKGWPDEKVYNVARKMVGACLQVITYKEYLPHVLGPGIMEDYRLSIPTPHYYYNATLNPSLLNPYATAANRVSHAAVGTKFHREGQKCFHTTRVSYDLNTLDDFCKPKTDPVRALIMGAAYHNMQHQDTVYSKEITRFLFANPPNQFGKDLLSLDVNRGRDHGLPSYLHYRVLCGLKPVYSFDDFKKESKSYDAVNRLKAVYGNYFEDLDLIAGLALETPVHGSFYGPTTLCILGEEYYRIKYADRFWFENLYHPGAFSKEQVQDIAKVTLATLICRNTDVEYVQPNVFKMAGAGNAKVSCKTILAKTDYDYNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0Z2</accession>
    <name>A0A9D4Q0Z2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_016634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0Z2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027083"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="14350" checksum="7F6DDE9844511DC5" modified="2023-05-03" version="1">MAQQPAARKVFAESVVDFCKKYNFDGLDLDWEYPAARGGKPEDKANFVALLRELSQEFKPYGLLLTAAVSAGKHFMDPAYDVPQVSKYLDFINVMAYDYHGGWETKTGHHAPMYSRPEEKPEDPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1G1</accession>
    <name>A0A9D4Q1G1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1G1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029477"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057130"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000005">
        <property type="entry name" value="Ragulator complex protein LAMTOR5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7962649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="22652" checksum="81F4E1436C91CE73" modified="2023-05-03" version="1">MEAPLAKCLEEVVETGAVGIICADRHGLALHSSGPVQLKSAGVIATLASLAKEIDPSCDTTPTIHLESDSLDIMIQQKELVTLLHFANGVLGRHVVVQVEEKAGGDYAQSLDQGVDVNDDEALLEESLLLPTEGKANNGDVLASEEELLATPVTKEPPAAAKISLEAGSLGAQSTGVAAPAATPQKTVVTPTAKEPASTESEAKKVRLKTSDCDRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2L2</accession>
    <name>A0A9D4Q2L2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028489"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1310" mass="141551" checksum="4EE62DF5B56461F3" modified="2023-05-03" version="1">MSRRLSSQEASEAAGAYLQRQRGSRCSLEYPNSSLSPWYISDRNGVSLSNMTIRSPCQPRSVSGSMSGISYPTSVSSSIIPRTRTRLISASMSGGGQVIRGGGADSMPYVCRPLRVGTDTAITGSDQLFPLSVRVMPSHGRLAQSRSSSCSGGHAFIRHTTRVSVRVGSMTSNPAITERMRQASVGRRVTRRTIAVPAEASVSAGRVAQPSTTPPSSATLTDLKQLDATPGAFTSAQTDVDGPLGVTPTASTSSHEDVGRALFSDWANRKQEMFADVFKDRNDFFADLLKKRRDEEHQPIERVQKAPTADSSHSELFMTTISEMGEKDVPETSAENYTVHSTTVPSTTGTTAFEDKSPLQATTASTHPTSSEFDSYELSKTQAPEAPSEGVSKEILQDKAESQGGELVEYKSFDSQHKEVGTAPEAPKTDQGGVEGLKGTSVDPLITETKSDEKKGPLGESLPSEQLQSTKAMQVSSVGSIEAASTRSEVPSEVSGYGYVPAFTESTFEAPGATSEEHQLVPASLEGPFTSMVSDMTDFPAHDMSKTQEADVSRQLTTLQKPDHSEVQKQKGKIGGPVNVVPELTWSPSSDHPTEHSEGEPETTGEATFAAEPDFGAQQPKKDEKIERTVSDLVAGTFDGAENKDRGPLLSITKKEKHSCEITSERILKRRYGDKKPMESVTEARESFVVAGTESQFFDAAMRRENITEAGKSTSESSTREFEPSVVAGATSSGSLRAGGAPSTEEKASLSSVSVGYTQEPQANDDNTSSYGGDGLDDLECLKVRLFGRRLSQGPGDIADDEFRKSELTSSLSTSQVVCTDTPLLWEHTWSVDSGTGYAAATVLRDDVYQMSLLSSAAEGVANEDSTYEVPDSGKETKKSESTASPTFRDAFNDYATRHGEEQQDGNRTAQANPVQLKRSRSAGSESPANVDGEGRMQPLLKSAGANNEDDARDITFEVPDADDENKLVSHCGELRFENFRTVAERMADLSSRSEANIVYESFVAPAGKVSDTLGSVYYDTAFKVRVVDDYDLASIMYDRWNEDAASVAPTIKTFWTYSPHSFLMSVDESGTHCGIISAIVFEEEQAFCAANGVKREFLAEGAKRQLWDALLSVEHGKNLFTVVPADQVGAYYRHLGFYTSARGLILHGKLASDTDLAPLGQVPLPDGVEIVKFKKQMYSSLLSFDKSTLGFGRKRFWRMTLREGPISFRVALQGGSGSDGRVCGYAGLQNDVNGVPVVRWVVAADGQVAIRLLHNLLAGSLTFRQRGAWMALYARSHASAALLRHLDTSGFEPWMLLSIDGSPSYSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3M0</accession>
    <name>A0A9D4Q3M0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056080"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="35922" checksum="DBD9A92E3E9BD2D1" modified="2023-05-03" version="1">MEPPAKRFRFTIEVDIYMLREVREQDPYHNPALWLNVAENLSLALGRTISARAIRERCDLLLAQFAQEDRANLRKSGTEEQYGEKETLLQEIFDVARSHGYRIRPGAARKAASTSASSSQAPSGVDRAERRVASAVRDSASATLHAEPASGEDSTGFGDQPPPNLWSTSVFDNVEVVTTAPEEPYEVVGDFSQSSPAPQEEAAPRTAPVAAGGAAQAVGASAAAGAARARRGRRRRTADRHLEFFERRLALEAETRERAAAQEDRRLQLEERRLDLQERELQQRVREFNDVHEERREERAMILQQNRLLADVLQTLVNKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q416</accession>
    <name>A0A9D4Q416_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_023989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q416"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035472"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7963951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="373" mass="40221" checksum="88D554379835BC89" modified="2023-05-03" version="1">MGKAISRLWRKDEPPDATGMTPREKVAVRTVWSAFCKEHPDYGVLLFNAYFLKYPDNIKLFKHFKGKSLRTLSTDPEFSAHCSLVGEEITSIIEALDDVPRVLEILKKNALLHHRLRGVTPAHFTSFGQVVIDVLTANHEDLMTPATDNAWKKFFEFVVSFITVAYEKSSKNVMGSTASSYKVATMSTFYGAHPRGTVSSTGLNKAAASDATARGAGGRRASVTDGKAAAGTASTGLRRRQSITRKPEEDSALSHRKASLPTESHPLQTSDRLVVSEPVASAAHAGSRRPSVKSITDLSGKKPADFATASPASTSKRRASIATLGKGSDGGKPSDDQSTSADKSQSKSSQQSLGKRSSSKIRRPSISDKEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4Q5</accession>
    <name>A0A9D4Q4Q5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4Q5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11920" checksum="423AAE3D9673975C" modified="2023-05-03" version="1">MSATPEDYTATLCQKDRERYEEKTRLCAIHTLCGRPCKRCGLVAARRQTSSITAEQLKSRKALEGHNFVTSGWEPWANKFAADTVIIVAQVRRINYLTFPCVPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4T8</accession>
    <name>A0A9D4Q4T8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_005546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4T8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047281"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7968061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35372" checksum="389A6C3ADC379074" modified="2023-05-03" version="1">MSKKGVRVVGAGTCGLACARQMLDCGFNVVLYERSAELGGLWVYHDDDFEGRASVMRTTIVNTSKEMSASSDFPPPKELPNYMHNTEMLGYFRSYADHFGVTKNVKTRHDVVQVTPAANYDKTGRWDMLVRDLETNTDRPETFDAVAVCVGHHVHPNVPYFKGQEKFRGRIVHTHSLKNADSFRDRRVAVVGIGNSGGDAVVDISHVALEAYGLKPKHRYNAQHPTTNDALPSLILSGIVRIKKNVAQFTEDGATPLDDVTLATGYQIKFPFLPKEVVSVVENQVQLYKYVFPPQLRHPSLAIIGLVQPVGGMFPVAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4U4</accession>
    <name>A0A9D4Q4U4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_005827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028411"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040967"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048217"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058288"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000016">
        <property type="entry name" value="LARGE xylosyl- and glucuronyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000016">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="180"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="538"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1477" mass="168362" checksum="F05AD45651EB52B2" modified="2023-05-03" version="1">MNEPANFENFHERDTGCPPEEAMNPPPYVPGGEQLSTKTLCMSDRHHLLGGHPWKTAFHNIALHKPRSGIVVGPMVRRHHLELGPSEAQRMLSFSLYGIPMTGSDICGFFGDTNEEMCARWFELGAFYPFSRSHNMNGSRDQDPHSMGPVVVEAAKNALELRYTLLPYLYTLFHRSHVYGETVARPLFFEFPEDPNTHDIDEQFLWGSSLLFNPVLYENRSSVRTYIPRGVWYDLNANGSAYSEAEGGFHHLEAPLRSIQALVRGGSIIPCQLPAATTEVSRRSPLSLVVAPDERGTARGELFWDDGDSIDTVQREQYNTYTFMLIDRSQLVVSATHRGYADGLHLGTVVVYGVREKPTFVSLKGRSLEFRYDEKTKDYIGYRVEGIASHDEGIYIKLTRQTPSGIDDDVQSVDVNVVYYDRDTLSTLMPTDVVYGLGEQWTALRRSVDWKRYYLFTRDGSPRPNINLYGAHPFYVALENGGSSHGVYLHNSNFIEVLLQPAPAATFRSLGGVLDFFVFTGPTPGHVVQQYKSVVGFPAMPPYWALGFHLCRYGYRTLNRTREVMENNIQAGIPLDVQWNDIDYMKNWNDFTYDKHTYAGLPDFVAKVHEGGRHYVMIFDPGVSGSEMPGTYPPFDEGLEMDVFVKNVTGGIVYAKVWNNVSTVFPDFTHPNSSRYWTRQFRRFHDPSNFYNGHKDGCPRDQKVERPPYVPGHDPLCSRTLCMSDLHYASSHYNLHSVYSQLEARATYRALVEIRQKRPFIISRATSPGQGVWSGHWSGDILSSWEDMRLSIPNFLSFGMYGIPLAGADICGFAGNTTVELCARWQVLGAFYPFSRNHNNLNGKDQDPYSMGPEVVLATKNALIARYALLPYLYTLFYRSHVYGDTVARALFFDRTNPIWLFVAPHNRKAQGTLYWDDGESLDAVQEQKYSMFNFTLAEGCGATDHGARAPVAAMRRHRQAALLTLVVAVLGIPLLLLLYLDGKSQGFICVVHSASDDPLCSLSRQQLMQLMQREARNGSDINFLPCPTRGGNELPEVPKCEVLQVAIVCAGYNASRSVITLVKSILFYRKNPLHFHFISDAVAHLVLQTLFRSWNMPAAAISTFWIEVHVQIFYAVEVIVLDTDITFASDIAELWRIFHKYTSKQAIGLVENQSDWYLGKLWKNHRPWPALGRGFNTGVILLRLQRLRERNWMQMWKLIAEKELISMWFTSLADQDIFNAVLKQHTELLFRLPCQWNVQLSDNTLSELCYSEVQELKIIHWNSPKKLKVKNKHVEFFRNLYLTFLEYDGNLLRRELIGCNGTTSSSAGVHASHVQDALNLLDEDDPCYDFRRARVAQHRTHLYYIEYDYEPSPEGNDVTLVAQLSMDRLQMVEAVCKHWEGPISLALYMSDSEVQQFLSYTLSSEILQSRKNVGYHIVYKDGTFYPVNMLRNVALQQVNTPFVFLTDIDFLPMHGLYEYLKRSVFALGLESSRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q664</accession>
    <name>A0A9D4Q664_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q664"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034890"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="283"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="912" mass="100933" checksum="56A88EE25F3B1741" modified="2023-05-03" version="1">MAERDPCSELVVRTACAFLEVPDQGSHRGQQFLRAFVDDPSKLTLCATRTSDAQSLAFSVQASALKEGDERQLVFFKRRPQVLTAENLSGDVGVCALLAPSAAESLGACLRAVFQPLLASEPLLATSLGQLQAVLGTAHDGGSTTPKGKDEAALGQHWCALGAASLDECADWLDAGLALLEDLRHTKSLDSLHNALGRGLAARLETLLSDLDSWRAPLTKVQQELGLALSACGRSPSADAVLGVRIRTMLQARLTQEQLVRLAPPTTREPLPAAPRLSDPEPEWRAAMALHTQWLAPLAARAAATLRERLMRTTGLSLLQECKSYSELLKHPDVQAQLAPERDVLLRALSECMVEAKKSYEQTSCSIQGVPDVVRDIVGLQELRTRLEEAREVVRLLNDGSNSWETLVEKLNRACDEAREAAADRLDGWSRNAQQIATKTSLQEDEPALILGAGGRPRVSLSPRLASIASEARQLRALGCRLPPGPLRQLEDTAARVGHRARHLQQVASFYSTVADQMIPSQRPLMLGLAEELTGALRQRVPWGDVTALDAFVGRLRGLAARLAGRNRHLRALHLAVCRKVMSLFDLDLVCRQQNWKDVLNDIRATMAQQQESPEQVRPWRAHWDRQLYKALECQYLRGLETLLQYLPETRVELTCRSGQLCFRPPLEEVRSRYYQQVKRFLALPLHFRGVSDDLAVDQSLVFSVIVDRNAHQFVDLYRRTQRLFASVQASAGRFQEWVALSSLDLQTFAEGLSPEEWKNSFRTVKAKCQEFGKAFPDEERFECLVVSYAPVRSHVDFALSELESGLVRELRASVARDAAAVRSYLESSLDALAGSAQTAEELAQLSAAFGRTVAGRDQAAAMHAAARDKQQLLARWSRRPPPADMDGLQQLWHTLDEKLHQHRDVVAHQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q674</accession>
    <name>A0A9D4Q674_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q674"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041405"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="21708" checksum="E0BAA6739D94709C" modified="2023-05-03" version="1">MTVTSPSRSSLPPASSEAIALARLSRIAGAEGFLPDQQTGFRHHRCTADTIADVVSTVEDSRSKGEEAVLVLLDVRWTFRVRVRRATSDPRPVTVGVPQGCVLSPFLFSLEMAVLPATLPVDKRFPTQCSLNADDVALWVRGPRQNFSAITTSLQRSLKAVASFQMDIGLCHRQTRMLCWCTQGLQPGNASKGCFFETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q811</accession>
    <name>A0A9D4Q811_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein pinocchio</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q811"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034895"/>
    <dbReference type="OMA" id="RPCPHCN"/>
    <dbReference type="OrthoDB" id="10062522at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17962" checksum="18B575392A2E844B" modified="2023-05-03" version="1">MASGVIVSYPSPAPHESRPTVFKKDRRMRHSKSDPVLMALSHNSFARYSEREKCWDSIDDLALEQLQSDASDAMTLEGLKSHYNCCFTCGVSWSEEQTCLDCSECGGYALHRPCPHCNGTCDGLWSRDLDATHKMRRAQWMGECKKAPRDNTPKNQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q989</accession>
    <name>A0A9D4Q989_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q989"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7971756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="11815" checksum="62DCD04B5F15976C" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYHPLPGTRDFRVSPPSTRAVPPGPHFCGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9T6</accession>
    <name>A0A9D4Q9T6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_011585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9T6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047247"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="219"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="411" mass="43864" checksum="306A1761BA1DFD26" modified="2023-05-03" version="1">MDIWSSYAKDTGDDSPNAQKKPLVSESVNALSEDLAQFATGSAVTDAARSAASSASHGGDAIPSAKDNHDQLDLLSDFQPNAAAASSAPAAADSSTTPSAYDIGDLLHDASPAAGGAPLLKPSAPPAPEKVAPAAAEPDLEPRPEPKNPPPPKQTAPEELLPVADVKPTPVTSASTTKPKAAEMQREATSTTSFSKDRPSCCIFSPGSGWSPACLHPCVEELVYWRQPKKSGLVFGLVLAVLLSLTCFSLISVVAYLALGSLMVAIAFRVYRNVLQAVQKSSEGHPFKEYLEKDLSLPKERVHETVDVVIKHVDATVARLRSLFLVEDLVDSLKLALLFWVLTYVGSWFNGMTLIILAYVSAFTLPKVYETYKTEIDQYLGLARTHVGNVIGTIKSKIPMGGQQAQRPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBK0</accession>
    <name>A0A9D4QBK0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_009769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBK0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050255"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="9">
        <location>
            <begin position="186"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7972234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="593" mass="65219" checksum="78390D052F7571CB" modified="2023-05-03" version="1">MERPELSTDGGASPGSGQQRAQEQSDGGHSPEVQPALRHQQEQREERQEHHREVHEQPGLVQSHREAQQHQLRQQELLESRRRRRQTRLEASSVVSSTSDESSASTATSSTNSHSRTSGHSPTSLGCDLEARRRERRSSHREAHSVRVPLIYRPMGWSGLFTMRMSHPLPFSLEAELRGPLLQLPLDLCNALRQEVGHQGTVLLAPHHAACTLIMMHHGAAGETKRQLGRLLGLAEADAPPPGEAVTDDTAACGAGRRHRSFIDVFGVHACMLFCSDFHRPRRKLGAAGAMTSYLTLCHDASVHLAARYHKPLAMLSPQIHAMDFATCAEECRLYIDGLFRALSDFSFERPMFSGDCVGPDSWLVFASMALFDAKLPAQFQPSRGWFRNTCGSASAVRTLRRVGAPYRTARCDDISATVLEIPYNSPLLESLVVFLPDCPFGGLTSLERGLSKDKIMDCLDRLEQRGPVDVTLPRLRLRCATDFARLLPAMGVRDAFGDAADFSNMADMEEGSRGSGAGRLKVSAAKHFTVFRLGLRSAAARNEARSTGLPPIVDCADGRNLEFTVDRPFLFLVLGKDPSSVFFLGSVTKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC71</accession>
    <name>A0A9D4QC71_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC71"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="13243" checksum="017F65AF51EBF052" modified="2023-05-03" version="1">MEVLCAPSVLLLYRCPYDINYNTPPELAPFAPTDLCNVARRALQPWRIHDTCPDENSFQFGHHTPEGSTGVHRRHQRDERRATTPMKEMSFVLRFRNMVAPTKVMNFAHHLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCV2</accession>
    <name>A0A9D4QCV2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCV2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74130" checksum="D74698DBF81348F6" modified="2023-05-03" version="1">MNGSAVMLEPRQESRTSPHQTTRLARAAAFCSSLTSKYPWHSFPILTCGLTLVVAFIVGAVYVTYLFEQRMQDTGATHFCCPNEVEQVFWYVNRSVIPCKDFFSYVCSNVISDASLVPEDRSLHSWRALITGHTAAGAGRTDIGRFVTAYYKSCMAIAAHKPSFMRSLASALVKVAWKEASVFKSKEAFTYMTTASVVYRLPSVVYISFDVLKQAMSVKVNLVCNMGTQDFDALAPVLDALSRTLNATTEEAVRRYALAFCSDLSAAGRTRKRYAMANESAVFDREVWNIDDVRAGLEGCGFSLRNVTSVDVQGVGEVRTFYSAFAANEDSEATAKTIAYLVWYSVFLGSGGFYRSFDGSAPSVFRVCMASLRFISEIQSAFSAAQFMSPEKDVEARKIFARVRNSVYADCQHYSLIDSEDSAACESFFKNMQIVSSADLAESLVPIPNATDTFGENLLRGRAYGFEVVKRRHSSYVSGKMSRYGYVDFSGDKWLQLSSIVYKYLSASSGEHNLRNYAFVGRLLAETLWYMVFTHANWSTRTLDKIGIFRRCFVSNHPSSNLPAAPIALTIATMGLASTLHALNVSDWYDPVVVGSMWRVSHAQFFYILTTYHKCPTKWDSRIAQTTNVSLQYLDDFANAFHCPKTDAFAKIRQCVLEVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD12</accession>
    <name>A0A9D4QD12_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051515"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057497"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="211" mass="23320" checksum="B3DA5325DEA01E55" modified="2023-05-03" version="1">MELDPASGLSARILLLPQWRSGASRDAPHLTPLSLRQTFASYEQNQGDFSVLFPGHYYLSAQRETQVLGYSVAYRVVKILPWFCAVVSTANNGTQPGFFEVPQRGNDTADRLLDITYPAGVTSSLDSLEKVQPGDDLFRGYGSWLTDSMPKSPLLLVQKCFAILTDCWSMVMLLLVSGDIEENPGPNSGSKVTEMLQAIIDRQEESDRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFD9</accession>
    <name>A0A9D4QFD9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFD9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="639" mass="72028" checksum="76D42CA7C9600FD1" modified="2023-05-03" version="1">MADPTSSQCQAATSYVPERPVYVRLSWYRLRFAVVFVSLVIAAVLAAVSIGVYAESRWRRLRRSTAAAGTHSFCCPEDAREAARYLNTSLDPCQDFYARVCDGVIKFKLWKQIVRQSELERIMVTGVVPRALRSVDATQFIIRYYKSCIETISQEDEFISNMARALARETRGFLGNPDSRNALAYVAAASLWYKLPSAIEVGYDAEIPVVTLSVVADTVCDAGDLPPRVVSSSAHAVEEVANVSVTPDEVLQLSARVCSRYRSVSVKYHWNGNGHDFNRSVWNLDDLRSALVVVGYVVDEKTRIRVNDVAGLRAVLGFYGDVDHQANGAKAGYLLLHSLASLTRQFYPAHDVGSWQHVFQVCNDSVGQIEMVWGLFAAEVLTTPEKDDRLRRIFDAVRDAVYKDCRANLVSDTEDVERLRDLIGRLSLYLTMDARWANVSVPKATRDFAENLLRGRVYDFHAKRERQLQSGRHQNASAIRYLWVPLVMYDIIRTGSEIPDMATLGWWMAQIIWDEVLDSRFWTPKAEAVIQRLRSCFESDGHGEAASVSFNLGLSSVLKAFSRPDWHTVRQAWSLLRMSHAEIFYTLAVYYRCPTRVSPRRARLINEALAYAGDIASAFRCPSDSPMAKKSRCSLSQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG10</accession>
    <name>A0A9D4QG10_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG10"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67572" checksum="775EA5B77CD9C6A4" modified="2023-05-03" version="1">MSVEGEDVTQQEYEDEAGWRVVKRRGRANERTILHGAKDEATHFSSVNAVNNKWSKGQRARQIMAASRMPSLPKEDHKIIVRPRDGFKVTDYGINRLECCVANAAEIPRKESEEDTVCANYKQNILVVSTPSEERAEKYRAIARLRIGDKEFEANAYESASKDTSKGVIRGVTHEVSPREIVEMPVTPRNPTVLMAKRMGNTTNVIILFEGHHVPNYVRYGTGQCGRLGHRADVCPNSRICRGCGTENPPQDHECEAKCQFCGKDNPTADRRCKARYKIPYLVRRRRWERARRDEEEAMYYEKEAEALYRQGRHDWRQQPEHQAWDGSGPDAFPKHQPREKGRSTSNNKTRSGSRSRSRSRSRSSSMSRPNTSTTGSPRPEEGAGSQSPKGTSSINGTAGPFKVSWADAASGARAEAEAALQNRIQALENELAHIRQSNVAFMNEIRKLRAENELLKSGRVTRNEETSRVVAEEKDAVMKYEAAVPIKRKTENAPMKTGVKKPKPAKTLPEGQEEFAKNIEAKVEQIETTLQTKLEQQEVRFEAKLEALGKTILQQVQQMMADFDEKLAIWGPQTSGGGPVKTSIKPYTRTPIPAEASENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG15</accession>
    <name>A0A9D4QG15_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UvrD-like helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28612" checksum="8969ED7E1F5FB869" modified="2023-05-03" version="1">MAIHKSQGGTFDTVVYDYAKAHPQKLVYVALSRVTTIQGVYLANLHQDHTFYHHLSNADNALVSEYERINKHGLDTAYARCRAHPATVYTVDLLNVRSLICHMADVRGDRLSTTADVLLFTEVIVATRSQAVTIPELSMVAYASRVDAARSSGACIYVRNGIAASELPNVAVPTGEACAVQLDESGMVIEAIRVDFNFTGNIIRQSVDNGDITVALVFIRKNVVRTRWGQKHNIGYFCRIVGENHFHRFLQLFLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG45</accession>
    <name>A0A9D4QG45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG45"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="121" mass="13533" checksum="A587ECFC23643E06" modified="2023-05-03" version="1">MRHINWNLAVNHTTEGTDRAHCSSKLERGLWRLGNDDMSFSTRSSFEPPACPPVGTLGCVGLTNDAHFDRVVKSTKSLLLRREQLCGRTETTSAGETPHMPSSPTRTQAHHHPRPRYDNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGZ3</accession>
    <name>A0A9D4QGZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039978"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052415"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="124"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7982749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45422" checksum="FB57C832A53CD700" modified="2023-05-03" version="1">MPYRPGRVLDATGKYPTGMLRWSRSDIGAFDECIATVVRDSYGNEISHGQYCNLLVYVKKSATWEKTIEPLLNIMHPKNLNHGVQPKKELRSLITAVKAFSLVTNTRMLLRTAKRSDGDHYALQFLHGLRFFSLVHIVLGHCYETITDTTGTLMNILILSDRWLSMLIAAAFNSVETFFFLSGFFLCLTVGKRKANPMVIFIMGALRRVIRICVPLFFIIMCLCLLPVIVTGPDTKSFYQKLYVEVSSQWWHYVLQIRNFYELGTQHVLGHTWYLSADFQLFVVSLLTLALLQGKLSFGVYLIHYPFIELLLHSSRERMHWSDFNQVTMLFSVLDWSFILAYFSYLACEAPTAALDKLAFSKLTGGGRARKQKRRTEVNEDSASPEKKKEDVFSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJT7</accession>
    <name>A0A9D4QJT7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJT7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036389"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7982631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="170" mass="19616" checksum="225293AF870C81B5" modified="2023-05-03" version="1">MKYAEEHGKQEAGRKYDVDEKCVRYWIKQKDALAATNRSQKVFRGKKCRYPELEGELVKYVIDTRRDGYNVSTDMIRMKALAIARHMEIPQAQFNASRGWATRFTGYVVTSSASAAERRFFKSFQASTKAIPERLRGDWNCMNGTEDNRLWEDAEASSSENEDSDSEMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMC9</accession>
    <name>A0A9D4SMC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026925"/>
    <dbReference type="OMA" id="CIEAQCW"/>
    <dbReference type="OrthoDB" id="6498477at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="337"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7935193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="495" mass="55462" checksum="DB316B54C5DDA756" modified="2023-05-03" version="1">MNFFEPPILYYRRATGDNHHLIYLRPLRRRPERCKSQLGAELPKPDWDQIQPRPFEKNIYREHPTTASRSAAAVDDYRRANGVVIVKGRGPVANPILDFEEARSFPDDLVDAVRKERNGGTPTCIEAQCWPIVLSGRDFLGVVQAGSSKTHAYVVPAIAHSLSFQRPPNTGDGPLVVVLAPSRELVQQIHHLFRDLGQSLGLRSVCVHSGVAKGTQYAELALGCDVCIGTPGRLLEFVTEQRLKLFSCTFLVVDGADRMLAMGLEREVAKIAQQIRPDRQTVMWVGSWPKGTRRLIESLLDDYVQVNFGSAQPRAMGVKQSVCVVKKAEKEHALAELLEDLLRDEVERVVVFTKTQEAVRKVASRLRERNWRTVVVHRGMALEQRRWTLSTFRAGGFCVLLSTHGCGRDLALDGVRFLINLDFPVKPYGYAMFVNQLASVADEGGQLYTFFTPDDCRHAEELVATLRQAGQVVPRELCKLAKETCASVRPGRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPM9</accession>
    <name>A0A9D4SPM9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPM9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031944"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034061"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034626"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="80056" checksum="A961C9B2708B152F" modified="2023-05-03" version="1">MSHDEDHEGRTAIQWKGQLDLDRSCGAVSSDKTCWLCEDFPAWNTVMHALDLQLDEIAPATLRLRFDYNSRRRDLVTATREASIIVSSLLRHHLCVQEVHLQCAISSNTAAAQPSFPIFMRANTSAHLDLRDMDAIIGLEKLYIHIGRFSPCFGAEMDALLVRNRNTLKSVEIFESLQGLNKLGMVEHLAACKSLTLKSLSLRDTATPHVDGMLRKKVVGKTKMSHGEDHDASAAIQWKRNLELDRPCGAVDSNETCWLCDDFPAWNTVIYALDLVLAETAPGTLRLSFDPNTQEKEDLVTAAREASIVLTSLLRHHLCIQEVYLECAISSCTPAAQPSYPVFMCQNAGAHLDLRDMGAIIGLETLDINIRRFSQCFAAELDALLERNCNTLKKRRPFGSCFRTSLARQLLEDECYDRVRLGPWTEPYLRVLAPVLASSEACISELWLPDICQLSLETVSVVYKCLASNKVNRLTVAVFNEPDYRVSHLCETLKNNRSIQSLRIQMSNGNSANEILRALSENTAITELSMRLWVPALEETMTALSNMLSRNKAITSIYVDLDSESTRRYLEAIAQGISGNRLIISLGYCVPVGTYFPLGVFAPVRRNRAALNRAMDFALERREDRHCAECFELFFGRSCLITNLMEIGKMSDVEARIGVTSAENRRREKYLVLTGVVWSSVACGPTDVTQIDALNSDCWRAIARYLKVTDVRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQB4</accession>
    <name>A0A9D4SQB4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_023012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029537"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048322"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001297">
        <property type="entry name" value="Tissue-specific transplantation antigen P35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="11">
        <location>
            <begin position="459"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7940298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="770" mass="85642" checksum="078C69258429D81E" modified="2023-05-03" version="1">MGLKNVLMCAVAGVLAVFALRQWRVHTWGRCRSKRSMIGKTVVITGANSGLGKATAIELARRGARVILAVRDISGGLLAAADVRRVTSIENVVVRYLDLSSFSSIRAFANGVLKSEMHLDVLVCNAGVFQCPLTLTRDGFEMQMGVNHLGHFLLTNLLLDRLKNSQPSRVVVVTSNLYKRAKLKSSELLMDVSNYDKRLAYANSKLANVLFVRELSRRLRGTGVKAYAVSPGMVYTNLGRHTKLPWYLMVLLLPFALFAVRTPEQGCQSIVDCAVNEEYEQHSGKFYYNCRPEKLESIALDDDLALKVWAESEKLTARALELFVESLVTRASEITRSRSAKTLSTSHLKACILADERLLFLKELVSSVPDVQGDEEPYEVPPVRPKLTGVRKLRAKNGSTDVPGPSHSTAEETDSAEDEEDDYLEEDAPSAFTGQQQPFTSCLSRRARVEMTSTEEKVILVTGGTGLVGKAIETVVNEEKKSGERWVFVSSKDADLTNKQATEALFAKHKPTHVIHLAAMVGGLFRNMKYNLDFLRKNILINDNVLQTSFETGVQKVVSCLSTCIFPDKTTYPIDETMIHNGPPHDSNFGYSYAKRLIDVQNRAYHSQHGCNFTAVIPTNVFGPHDNFNLEDGHVLAGLINRTHQAKLHGSSLQVWGSGKPLRQFIYSLDLARLMVWTLREYDEVHPIILSVDEKDEISIKDAAKLITDAFNFKGDVIYSRSLTEPIKFDTSKADGQFKKTASNKKLRSYLPDFKFTPIAKGDRALGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQD2</accession>
    <name>A0A9D4SQD2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQD2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039808"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042127"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="806" mass="89602" checksum="B3C9D878E5FBA77B" modified="2023-05-03" version="1">MGDVFCLVMLESGSRRKLKLQTGAYEELLAGLSGIDEFDSRNTLIQIFDADLEDFVDLMPGDVVPHKAKVRVVRKNNPAPSSVAASPVKASSSTSHPSQQFVHQIAPRSPASPEKVFHISRQGDQLHYSIQSSDVSVAPTICTLGDVLTQAPYVNIKKSSNSDAEALESMITSVEDVPDAPAAHSQEMKPLIAPAQSNKTAEPGDAVMRLSRVTEDLRAMLPDHLVTDDVKQLVPNSAIIPKHEHDRNDYLKFELPSSFGVWCDIALERKTLITPKLRRHIITVLFQACYKISLYPTMRLYRRAIDALMVKYPHIAEGPFNWQCWCLALRSKFKNTRRKLRRRPVSWALGVDEPLESSMSADSHGQSGGDASVGMEAMAFKVEPDQQSSEAMSDCSNFNSAELEDVTVSDLLSTCTDEAATEKLVDQAGGRALADGNTNGGELSLEGRPSLKDRDDMKFELPSFGVFEDALEMRQPVTNRLRRHITRCLFDCLLQDNPYPTSHLYRTAVDLLLHKYPHLIDTTGETGRELWVDSLKSKFKNVRRRLPEQVWSMSKVRSKYTTSPRRATAPPKPKEEGVGRASRPVAIQGVMSASTSSSWQTGPLGLGGMEGASDQNEAVAVKERSDSIRDMTVQQAIAAFPAYRQESALLADFKMLWNADIPECFEKGIKRMFLVLMNSGTKDEMEKISQAGNDILLMVLGAIARRVSESLDSLLTEGSTLPTPCLVQRPNGNIDLFVNGFYLLTASSLLGGMCVLFASFWVFHIEYPKGGRNILTFLEHAFLNLRHMKPRLKCWELINLYRSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQN3</accession>
    <name>A0A9D4SQN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_003997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054016"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057737"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7943014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="91554" checksum="71654FBEE3257B24" modified="2023-05-03" version="1">MVFKKSHFSDSVINYRTPCTSSEGRLCNVFRDLSVWNEYFWQVGLQLREFSPGQLSLVEMRHAKVLPNTFHQKEAVMLLWHFLSHHHCIASVHLNEHVFRRQCHHQLICEALRKSPSLTKLKLCRLNMTENASRRFRAALSHLNQLQELEFSHVTLNRTSLEGLSEFLATTRSLMTLTMTDQCIEGEDAVVVLQGLRKNVTISTLSLQTSLLSPVSSRCGEIFAEYLRCNKTLRSLTVTSSSRLCFFDFRPIIGALSYNNILSELNLIDFSLDTLSHEIITEMLIRNRGLRWFHMINCNFNEQDLYMNTWVPVLRSGSSPTSLWLAALAENSTLEELTLELSWIKPEDCSSFFKALASNTSLKKINVPTFRQDDVAQISRALRETGVPERFFVGQHHVCRETAAALPKCEVLSRIAIYRCSHEEVEPLHTALRLLPTCSHVKSLCLEMTGPTFNGRVSSLLAQYLTETTGLRELRLELLYGGRRSVDRSERTLLQALSNNNSIRRLSLKDLHISEREAQMLVDMLQSSRTLCHLSIYLYNWDATIWLLLMLAPSISSNYMLLGMRTEWRRWLLDYWYSIKDVVRRNNSLVTRAAHFITGMRHKRDDGQKQLVDLNRDCWLQIRQYVKVGDILDSKFANRASALSLLRPATTLPTPCLAPMSAMSPKQAEATESFFEKNKSLKRPLSPHLSIYAPQMSWMLSLVHRTTGCAMAVGAYGMGVIPFMCSHNFPHYVEALQAMHISPILTFPVKLGLAFCLSYHTFNGMRHLAWDLGLGFGLKELYATGYLAIALSLVMAVVLAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS96</accession>
    <name>A0A9D4SS96_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS96"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="185" mass="20698" checksum="6DE278C54481FBF2" modified="2023-05-03" version="1">MNPMEDDTSSPAVGPAARLRREAWQRRREPQSHQTSRHPHPVSLFRRSLMSRAHQLTLHSQAPGPVYLWQIAYKPWLHRTALAQRTSTADDVVADLAARVSVIEAQSNRQQRLSTSVEQNNIGPRMMTEAPLLSLGPFTEMPTLPVKLGDPPQRVEALVDTGAAFSFLTSIDPISSWLTELLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV92</accession>
    <name>A0A9D4SV92_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV92"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="73" mass="7950" checksum="428E1CF30D7B4FAC" modified="2023-05-03" version="1">MRCFAFSAGAKRDRTKATVKPRYKVVEFRRNIVRDPSTDLSTAALGGGDPASAIRSPLEGPKRALRNDQCALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVB9</accession>
    <name>A0A9D4SVB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 5">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 5"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044418"/>
    <dbReference type="OMA" id="WPDENDK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7950781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="173" mass="19469" checksum="7BAC87080EEAA0D7" modified="2023-05-03" version="1">MRAVIQRVRSAAVHVDGRVISSIGRGLCVLVGIHRDDTEDDIDYIVRKILNLKLFDDDAGKRWKLSARELQLEVLCVSQFTLYGTLKGNKPDFHLAMEGDHSKQFYERFLHKIRTEHKEDLVKDGQFGALMQVDIQNDGPVTLEIESSAFRKVVPLPQERGEPDGGAADDSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWU6</accession>
    <name>A0A9D4SWU6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWU6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="473" mass="50520" checksum="2354310F576FA0C8" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFWQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPPTRAVPPGPQPSHDRDLPSPATSLSTSRPATSAVVPAPDDQPDDVQVPTPEVPAPDDVLAAIDQSATRCVSSTTSADGPSGMPAIRPSSLSSPAHDTSLTSASTLATLPPELEADTDNLSPTVRPSLAEVSPSTVPEHDLSPTSKLCASCQQRPASSATSTAAEVRAPYQLRPHLRDAATMTEAHEDEMPAGSPMAEQAAHVTPATSTGLQHPDQRTSPPVPPAEGASTRTGASSEPAATTLARCHRRFAPEPLTQDAAHLTCGHCAGALCRHPRQRCARTGKTHRSSYSPMVARRGFTAPFRIVPRTSPAPALLHPPATPSSSRAHLRQPVRYRKAPSCRRGIRLDTTPAYFRLVPRPLRFSQSRPPETQGFPIVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX60</accession>
    <name>A0A9D4SX60_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_000892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX60"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034096"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051140"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000090">
        <property type="entry name" value="Leucine-zipper transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000139">
        <property type="entry name" value="Leucine-zipper transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="443"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="780"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7955448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="867" mass="96291" checksum="B39973CF71D87425" modified="2023-05-03" version="1">MPVPRSAHGAAVYDNRLWIFAGYDGNARLNDMWCVSLLGDSRTWEEVPQRGDCPPTCCNFPVAVARDSMFVFSGQSGAKITNSLFQFHFKDKYWSRISTEHILRGAPAPPTRRYGHTMVAFDRHLYVFGGTADSTLPNDLHCFDLDSQTWSIIQPSPDSEVPSGRLFHAAAVVGEAQYIFGGTVDNNVRSREMFRFQFSCYPKCTLHDDFGRLLETQQFCDVQFLVGLEEVSILAHVAFVAARSTWLRDKIRRAREALVIAEAEATFDGGGSVYPTAATLQVRLPDAVPEAFELVLTYIYTDRIDPTKKSRDPMSDRIVLLMMDVYRLAVQFHMRRLEHLCVQYLEAAINHRNVLVALQNASDLRLDFIKEFCLKFIVKESTYNQIVMSKEFETIAQPLMVEIIRRRQMPAVRSLLEPMFDYAGTTLEQDMEIFLKETGREFCDITLLLDGHPIPAHKSVLVARCSYFEAMFRSFMPDHNTVNIAIGEMIPSLQSFNTLLRYIYYGDISMPPEDSLYLFSAPYFYGFTNNRLQAFCKENLEMNVTFENVIQCNSSRYPAVLRAMESPAKASTVTTKASTVNGTPQKATKHQGTRLETDVEGNGYGRAETIEDIISELNATAKRDTSLAEAFDDVILNDDGQQSLDALDQCDPITDAKDSLSGSGDGGEVCSTPASAREEAKSAVVLTDDSAPAEGDGTAVSSASEIDSQGASKVVKAANGDSDQPLESQEVTECTDTLETDAEEKFVNECTENEAADFSNVTDADDCSGEVITGDIKAPDQAVMSPRRTARQRTASLKVTENAAVTPRRKTRHGSEASDASPVDPSSKKQELKEGCVTSDSEVDAPLSTRKLRKPREVPMDMQGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXF2</accession>
    <name>A0A9D4SXF2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXF2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="264" mass="29422" checksum="8B3092FB13E76BC8" modified="2023-05-03" version="1">MVGLVHELRPSMACIMQCTRRTSPSGPYGGALEKNYITYSRQPPAPNNTYRHVAWLVEQTSLSSNQSGNTSPNRRCRMTQATTSASSLPAKKSEKKPSFHHLATRGPNDISSRHSSPWHARRSLVASRVTCSLPYQRLTKGEQDQVDAMLRKAYKASLKLPPGTPTSRLLTLGLDTYAELFEAQLTTQLQRLTQTPRGRVLILRLGYIGQLHEAARRKPIPDHLRTTYKPPSPAIRIPDCIRAGGKPDWKPSNETTGTGTFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZE1</accession>
    <name>A0A9D4SZE1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZE1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20671" checksum="B4ECA366D1A780F9" modified="2023-05-03" version="1">MRTQGVDVLQTRMLGDMKTAVITFHGELVPRFVYYRGGKFPRYPYKNTMQVCKVCYHAGHRSDVYPPPDSPVCRICCHARSCSQSRMLAQVCDLRRRPPHGRSQLQEEAETTATQTLQNFEHVNLAPGRLTWRSRFDNDSEAEADAAGIATIHQVDTLRNARSHDRLIFLGDFNAHHTTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZZ8</accession>
    <name>A0A9D4SZZ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276:SF2">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16390" checksum="3133965851FD6321" modified="2023-05-03" version="1">MPPSNMAPQPVGFAAGLKAAEDKITSLQMRGRVPAALPILAVESFIVELTPDSWFDMHCLVLKDDSSGVFLHTFGQPTPVPAEFIAEIQDRTPADYPLRWCGLAVTVGEVASPRLVVPQSEWRAVLGGISDAQLVSSAACALASMYRRALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T082</accession>
    <name>A0A9D4T082_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T082"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049036"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="23664" checksum="A7D9E947A8178FC9" modified="2023-05-03" version="1">MAATSDERLSPTNVKAGTQAPGSAGQLTSCLSGEWASGLSDFTAAAPDAKIGKGSSSNLDDTKAGKSSKTLSAEQLTDVEKTEAMKDTLAMACKLNATLSAEQVADVVHDVSKKAALAVVDKLNLLGSLGSSALEKEAALDTDKLDANTSGSKVADTEKAVSKKQGQAEKAEPRPALELNANLSDDRDILGPMKRTIITFSEFITMMAKDVLAVNTEEEFKQVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1B7</accession>
    <name>A0A9D4T1B7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_018817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1B7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058148"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="230"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="613" mass="68758" checksum="850DE0D987CC318A" modified="2023-05-03" version="1">MKEAGGLEATNWPREHAQKKNALRRERPRSRPSPSVLEPYFAEQRQPGRPASSPPAMEAPTVVARLPDHRVVQRLAPPRRPPPAPDEQADAFTSTVCVALTLVVMFALMVTLQIYLVESSTIQDLLGFNMSFNPDTLFVSNATSQPRPPANASTGTPRNKTAVSLPGRKNASSRRKGRGAGQLGDPPTRGAVRPVESQSTAVAASEEAPTTTTTAPASYTLWPDVMYHRYRSVCMYKARRKTRSRAGYNFGIDVFPYHLCTDAVYCCAGINASDATIKPGDPTTDVFRHGWRKFSQLKSKNAFLRVWIAVGGREGGEASEEDRGAYSKITREESLASLFTANAVDWLEAQSFDGLLLYWKFPEIHEMNGLIDLLRIMRASFRRLDHSVGVIVPLDHRLRERFDMRDLVDLMDDYSILVDPTEPVPPTYGKTALKWTQDVIERYAEVFRETQYTVRGHRRSGRFQLCYPLDIASTTYTLYASDADDNTTDDGVDASGPGQEGRSTRSPGRLAYDELCLRHRWDATQDRPYCRVVLYGNQWISHPTPHSLEAFVRALMKVTGSTRCLGIWDPFWDDFAGHCDQGTYPLVQTIFNTERAIEKMTRRTPATKDTGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1L6</accession>
    <name>A0A9D4T1L6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Salivary secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1L6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047836"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28174" checksum="2F9FF0522E6FD642" modified="2023-05-03" version="1">MLVGVREDDGDNAKMNEKDAVHRDNILTAIMLKLCILVLATVSYVSSAGVSDANTFVDTIFREKMPFLVKGSPRLFPYATIADFKFKVYKNQITNRDLKVNMTRGEIRGLDTALQRLGDCQAPFLRDGQTVVVCNLAVQGLNITFTSLAKGDTLVAIWKTIWVNVGVKDTMAQFEASAPIGQGGTLRTFLIDDIRLDVTYDSNLSLNEGRQQKFKEEIIVRVKDELRHIFYNDYKDLLRRAVESVTFPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T201</accession>
    <name>A0A9D4T201_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T201"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052419"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7968926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="646" mass="69250" checksum="460629752A7EFB9F" modified="2023-05-03" version="1">MPPPKEHFFNVRTPPGTSVDEVIDALEGLVGIQEIYSVQHHGGFDFQVGVNSVAAVQTLLETGGLRLGTRTVPLVPVARQVASVTCLYLPCYVPDNEVVTGLKSYGTTLRIEEARYKDRPSIRTGTRYIKMDMRLENPLPNFARVGGHRATFEYRGVRRLCRRCNQEGHFKAQCDTPHCARCGVFGHRTDTCTEPCRRCGGAHASVDCTTRKSYSMAAAMDVDEFPALGTATVAGQTQRRMTTLRPAKRPEPNEDGPEPQVIPEKTLAQAAAITAPTAPAQQQEGRQTDAPTPASMRSGERQEEEGSHGHAEPNQAAAATEAERAADSGEGEKRGVHGARNASGDDEGEDDAASAVSWASVDETAAEESCHEDGQGVGKEDRPEARKGSQGERKLSLKERTGPAASTAAHSPWWNKTGDDDVPRGREAPQPTNDQPVSGSVEQEKSRKAPGEGDAPKPTEPPISSQKQPRPEPAPQHGGAAQQHSREGAQHGVQHGEAGGKTSRGEKTAAAVLEAQKPAGTPSSDELEPGELVIDERAPTSPESPKHTQQQPLSMPAGVGRGRYSRSRDSEAAHGGTLFQSLRPSGPGAHKADGGRPQRSVKKVRRDAAGRLRSRTSGSEHEEATSKQRPSQRPAADDMDTDSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T241</accession>
    <name>A0A9D4T241_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T241"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="353" mass="38543" checksum="6E20A6B8EB7047E6" modified="2023-05-03" version="1">MVRIPLVNNTFTLSVANSTHAQAYLCITSLTVSGKTFTVHLYAPPPDDALAAYSTTPSTTSRTKTSLTTSRQAILPSLLWVVVSWASPLTYWSPSWTLSCRRGSSTTVPSFASFGSATKWKPASIAVRPATGPMCAPSRGRNGAIVAPLLTPHRPKDRCPLAPSDASSATGITPHTAPTANTATCSALNVRRPWYLTLAPRHLVRPQQPRDLPSKLQVLPHHFHPQVGSLPFRPSHQRYLKAHISPCIRHGPVAPPARPRSHMSLHFSKKTPPTAAYCSKRSNCGSEDPDYFPLAQLQDFEEKLESAITVLSFLPSPIHSFSDMDIRTLKDVLASAADPTPPFNFLTFLKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T486</accession>
    <name>A0A9D4T486_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T486"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053316"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7969509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="238" mass="27046" checksum="C93130FD7875307F" modified="2023-05-03" version="1">MEQQQRADDPCTGEEEHPCICCELVFPTAERLAVHAKVHRGGPRRPFKCTECCRRFLRTEKLRAHQLVHRVGKPHKCELCPKAFTCKASTPALNSRTTGFGTRGSGPSSVVSANRRFAGRAEQLNHERTHDGDRPYHCPVCKRSFGRNSILERHMMRHTGERPYKCHLCPNTFTRLYLLLEHCKDHPQPQSNMGYFFSESLSNGEIQIPGFNNMSLDRLAALADRISNTSYSAKLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4P7</accession>
    <name>A0A9D4T4P7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4P7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="70"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="344" mass="39173" checksum="261BC4CA63BCD23C" modified="2023-05-03" version="1">MQHLRLSAQAWEVQGGGHSLLSEVSVKELQREKSIILTNDLPIPPAPPPDEIASDFIRRLSRRAACNVCRAPGIHIYTDGSYANLSAGAAYVVLDPNPSIMRVDRFRLLHIAFIEALRHVLEARYTIRVAIYTDCLLVLQAIASPQNAEPHVMEIRQLLNTIRRRSPIHLYHVPGHSGVFGNGIADHLSQRATRVGLLRRSPSPFRAVRRQFRQELLALWTDRWRADFRRTELYRWVQDLRDLPSFFPPPQPLVTLLTGHGRFPQYFYRFGLMRYPRCPCGAYSVDMSHVLHACAITTPYASRIRPQEAFTAGRYADMLQSPHNRALLIRAVRALSEAIPHVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6U8</accession>
    <name>A0A9D4T6U8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6U8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044722"/>
    <dbReference type="OMA" id="FRENRHG"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="29953" checksum="D1CA99572DF82402" modified="2023-05-03" version="1">MALNFSGDDYGSFKGRLGRGCSWTREETLLLLDLYEKERLNDERADYPPHNTPKYQKVHQAISGFLGAHGYSRTPMQVRERLKRLKRDFRENRHGEFTDRVGTILAKRAALGAPASPPNGSVAVATVAGPHSSPEHSLEACCPAVLVKTELGEQLQSSQGSTLRNPRADWQPLPVVRAPEPRVEKQRPPAEEPAERPVVAASSNGGPRARRTLQQRVVRLLGQLLAESRRQTQAAEAFQQQLLYQMHLISCSLQVLAAGSPQGPLKRDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6V5</accession>
    <name>A0A9D4T6V5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6V5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="503" mass="54602" checksum="6456105C300B00D0" modified="2023-05-03" version="1">MEVEGEPLSPEEFRKDSGWQTVAARCSRTKSAPVEPAGAISTGANPNEGVAAQGRRDRGTAKAKIIRGGRKPPLPKDDVKIIDRPRGGLNTSKVGPTVVAEVIWYAVAIDSATRDSDTMCPNLQQNIMVVSTPSRENVTRYIKVECIAVGCQQHEVNAYEAAPHSTCKGVVRNIAPSDGPEELDCKIFTSKNPLALGAKRIKNTGTVVVVFDGCKVPNYVSCGGTLVRCTLYRKQCGGVIRMWPPWASNRRLPYPDEAVCRRCGMANLDEQHKCDPKCRLRKSPAFAKDDRQFPTHAGRSASCGSSRSRSPSPPATSGPSERRSRCRRISKSRGKSGFRGKSRSRSRSRSVYRTRSGSSFGQQRKMKSNLTLAENIRGGSEAGPSRGPCDPLPEQAKDGEVMRLHTENAELKEIIKKMASERTEIKKLVISQSVSGKASAPNTTEVPFPASDSAGVPKHRALSSKEQSGSQINEIKGMLATLTTSVHKLQQRLAQVQVTLGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7W6</accession>
    <name>A0A9D4T7W6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_020133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7W6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044580"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7976824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13426" checksum="C84DFDAD8DE994FF" modified="2023-05-03" version="1">MRFHPADYAVFCLLTAFSFALGLYYSVRRTDRKRSAFAHSAAQHEEVFLGGRSLPAWSLSISLLASVATGVGVVSLSAHQYAYGLHFAWNIVSLAFTTPFIVYVFLPVLYRLRVTSVFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T819</accession>
    <name>A0A9D4T819_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T819"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12682" checksum="022DC1E2EBD9F3F9" modified="2023-05-03" version="1">MQRMRRKRVRVAPPPRARDHRLQLSGLAARRPTTTYARKHQEPGPHLLSRSPLLPSLVPPASVRRLPRLSRPAYEGAEELHVTRATRYAPQSRRRPASATRGNTHRNGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T977</accession>
    <name>A0A9D4T977_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T977"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032370"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034559"/>
    <dbReference type="OrthoDB" id="6482798at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039348787" evidence="1">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24061" checksum="0FFF9BFC42B7AFF7" modified="2023-05-03" version="1">MIAIACIFGASLLGQAYGLADAVYEANNYLDTVLGVVLPLQVNAANMTTILLPGFTVHHSDDTGEVNVSFDSGVLVGFGKYWQRRGDCQAAHWRNENITTTCHATLDGMLLLLDGIVEDSSSTIDENVTLILIVRNSSARIAPTERKKGYAVHLDLSLERLSLDVVPTRALTPLPGVPKSVFKKELNLGASAILRRFIETEAREGVLRHAFSLIHLPLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9U9</accession>
    <name>A0A9D4T9U9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9U9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054628"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039154523" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15280" checksum="AF7369798AE698AD" modified="2023-05-03" version="1">MVRSCLCRGVLAAVLVPAALTVALLARCARAIDIRPVLEEDTSSLLENRTFAQRFMVPSGDGANGGGNISHDEASVLELWQTYDKGLRGQVDNLLRQALPYLLEIGDVGIDIRCAQSLLKIVFGLRKLEKWAFKRKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA31</accession>
    <name>A0A9D4TA31_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA31"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035370"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="17689" checksum="0C761C3253EEE97F" modified="2023-05-03" version="1">MVCAFGSLVHVAVGQPMDLGIVETTRKLYHKVLLQRALTAYDASKRHNIYLLGVIHLLNFSWKELAPSKVANCSAHANFLAPSSATLLDDDRTWSNLCEAVRKIAGQEVEGSFEMFALADAAASVVAPATDAEIVDPVGGPDEDAQPHEMPTTVQTREYLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA60</accession>
    <name>A0A9D4TA60_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA60"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="80" mass="8234" checksum="956EDA3C5D424D75" modified="2023-05-03" version="1">MSVDDFVEADCNVQAVASIADEEIVAAVAGTQDVQADSSSGDEDYPDEAAATRAYSAAEVAAAFGSIRRLIEAVTPGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB34</accession>
    <name>A0A9D4TB34_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB34"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040206"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRNT" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7984203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="66" mass="6955" checksum="CAE5AFEE82C15910" modified="2023-05-03" version="1">MPAALKGKAVAELHEDDMICDHGATGGCQRASPCPFPCTCMDGVVDCRDKGLTALPQHIPETTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBR7</accession>
    <name>A0A9D4TBR7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBR7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054109"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038342871" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="101" mass="10736" checksum="DB39B3B98CD432DD" modified="2023-05-03" version="1">MAAVLLLLAVVLVAAGASAGSSKQHIPAASGARVLQKRASTGSRATGPAGEWWKVWWQNYIPEVTDPTAVPHLTTPTPEEYGPEPRPQPRPPTRPSQEPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBT3</accession>
    <name>A0A9D4TBT3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBT3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24811" checksum="D2590F68052D0F7B" modified="2023-05-03" version="1">MSPRFRRHKTKDCVSGDCQAHGKDRSPIPTARDVKDFLAEQHIPLLEWPPKGAHLNVIENVWGHLKTALAKKPLLFRNFGPVVGRSQERVGKEHVLSTRWYFDGLRCREWHFPAGRCPAARAFRSRAHCASACAASSANGPQKKSPQDDRCGTAQSRPCEERQLRFLYFADVSSGDNHVRCLKASQATLVGRRCLVGPNRYETLAQCRAACVRGGDEGAVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCJ2</accession>
    <name>A0A9D4TCJ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001031">
        <property type="protein sequence ID" value="KAH7985249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026990"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029893"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7985249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24511" checksum="7C1EC43915042586" modified="2023-05-03" version="1">MIAHCPVAVVRQTENAQWSANVQRNTTMVLYCAHKGEISTEPLCDNSVGSMLLFEAQAGALRTLRYRRHFDANPDVQVALCKVCGGEQETTEHIVLKCTQLTPRPTEGTTLPLALGFESTEDRRNDAVSVHSFDGSKEEAAAFLDLGLFIGINGCSLKTAENLAVAATIPRDRLLIETDCPWCEIRPTHAGAKLIRTSFPAKKKERFEPGFMVKGRNEPANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YMY5</accession>
    <name>A0A9D4YMY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YMY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055826"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF28">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="18329" checksum="67FCCCB543C430DF" modified="2023-05-03" version="1">MGARPIFRGMRQNDNQSEDDPYSTPLGNVAYTPNQPQDQDLGTSICASYEEKNMHMAGGPRLVIVEQPMKETRYRYKSESGSHGPLVGQSSTQQRKTFHTVMLENYNVQLPHRLKASLVTAEDTARPHVHSITMRGRDDEDCCYVTACENGSAMFPNMSIVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YN56</accession>
    <name>A0A9D4YN56_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_010533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YN56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049510"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7983261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="144" mass="16853" checksum="28013264ADAFB1EB" modified="2023-05-03" version="1">MCRICREGDQKARLVSPCSCSGTIGFVHVSCLEHWLNERNADYCELCGERFQMAAQPVSVLRFFRWAWRNKRWLWRSLVFELLGLVLVTPVAACVFYVLAILTLQEDGAAWYVVLLDFLSIVAFIFYVVRTLNKLRTRYRMYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPM2</accession>
    <name>A0A9D4YPM2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPM2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026859"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21896" checksum="871C2BCAD6C08963" modified="2023-05-03" version="1">MASTMASEQGGPACGAASPSIVVQALEATGHCPYSPPCTRSQKGNAYKDLSGNHFCRQRRRTRGVDKREGIKQAQEDSASVRGSFRHFMHRADDIVHGSKDRKRLSKSHCQYRRLRPGSVPTIFPGCPSYLSVSDHNTRETPDAKRSRKEASQLAHAVEESLASYEAEQERDRFSSLEELKARLQVVSVSPKWTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQX6</accession>
    <name>A0A9D4YQX6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQX6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050808"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7984612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="230" mass="26034" checksum="DA1FDD51EE35067E" modified="2023-05-03" version="1">MVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMVAPREINLRRVLVGHRAAVNVVDFDERYVVSASGDRTIKVWGTPNCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKVWDLAAALDPRAPAGTLCLRTLVEHSGRVFRLQFDDFQIVSSSHDDTILIWDFLHLPSEAASSPLPPRTYTYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR25</accession>
    <name>A0A9D4YR25_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR25"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="121" mass="12775" checksum="DF516D8E5EA1A651" modified="2023-05-03" version="1">MHMAGAPEGPSAEAVEKTDLSVDWPMTAATSCTSSGGWSGAGINTLVAGCELGPRSRSRGSQVLVKGRLRAGWYRSLRRRGALELATPPKRAVRLAVAGKHRSAEVMVRLRAGCRCGIKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRH5</accession>
    <name>A0A9D4YRH5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_025341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000685">
        <property type="protein sequence ID" value="KAH7985869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRH5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034783"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7985869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15591" checksum="CDBCD7150CA9694E" modified="2023-05-03" version="1">MERDTKHTSCNCLDFNKMAKVKKVVDEAREQNNPELDLVDRGITSIEEIPGLFVPASIANLYNLEILTLCNNQIVELPSSISTMPKLKILNLAINRLSSLPRGFGAFPVLEVLDLTYNNLNEQSLSNNFFIMDTCEPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P980</accession>
    <name>A0A9D4P980_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="21">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HPB52_024820</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Rsan-2018</strain>
            <tissue evidence="25">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="21"/>
    <dbReference type="EMBL" id="JABSTV010001672">
        <property type="protein sequence ID" value="KAH7932236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P980"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035524"/>
    <dbReference type="OMA" id="SSRGEMF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043426">
        <property type="term" value="F:MRF binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000027">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000029">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.10:FF:000001">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000002">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017366">
        <property type="entry name" value="Hist_Lys-spec_deMease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038051">
        <property type="entry name" value="Histone_Lys-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 21" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 21 22" id="KW-0274">FAD</keyword>
    <keyword evidence="10 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0678">Repressor</keyword>
    <keyword evidence="18 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="16 21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SWIRM" evidence="24">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="766"/>
            <end position="767"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH7932236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="798" mass="88240" checksum="403C26F505312F55" modified="2023-05-03" version="1">MSSSDDRKRPSPQEVFSADQEAGSELRDDDPTGRRTTRRRRARLDPKEMGDRQAAGGTAGPPGDDGASYASDEESGNGQHAKQARLGSAADRRGERPAAAATSEGGGQDCPDVDSEMEDPTGLEGAAFQSRLPFDKMTAQEAACFPDVAQGPQQTQKVFLHIRNRLLQLWLQNPKMQLIFENALPQIEPPYNSDAPFVMRVHAYLERQGLINFGVYERIRGPPAKKHGKVIVVGAGISGLAAAQQLQQFGMEVIVLEARDRVGGRVATFRKGNYIADLGAMVVTGLGGNPVAVLSRQIKMELHRIRQKCPLYESNGTTVPKDKDEMVEREFNRLLEATSYLSHQLDFNYVQGKPVSLGQALEWVIKLQEKHVKEKQIEHWKLILEMQEKLKTNQQRMLQLRDHIEALHQQHKELASSKAQRDVTQEFVLRSKQHELTCACRDWDQLVEQQKEIEDKLQEMEASPPSDVYLSSRDRQVLDWHFANLEFANATPLNNLSLKHWDQDDDFEFTGAHLTVRNGYSCVPVALAEGLEIRLNTAVKQIRHGSTGVEVLAANTRSSGGLISFKADAVLSTLPLGVMKQAVQGNPNVPNTVQFIPPLPEWKVSSIQRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGELFLFWNLYRAPVLLALVAGEAAAIMENVSDDVIVGRCLAVLKGIFGSVPQPKETVVTRWRADPWSRGSYSYVATGASGSDYDILATPVTPPSVVPGSSQPQSLPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGCPYAPPRQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBI9</accession>
    <name>A0A9D4PBI9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001740">
        <property type="protein sequence ID" value="KAH7932070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057162"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7932070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="18747" checksum="5A6388200DC0192D" modified="2023-05-03" version="1">MAGLLQPPTAANGNAGGVCAAGGLSAPSSPSLGNRLTVPGCQGPRDRKYSLPLQLQRRPSLSGYAAAVESAREDARRRKFSQVGQVVSHRLSTTIGWKVYTVTTQEVADQAKSLCGRYLRAKLKQCGAVHKKLGLQRLRSVSNLSVGYPTSDVAQRLRLVCSELESSHPDLYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC00</accession>
    <name>A0A9D4PC00_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC00"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="53489" checksum="16559A55F3B0A28D" modified="2023-05-03" version="1">MAAVHSNLPVRENSFFFNAPDGDVSIDDLIDAIEITAGEDSVHVLQHMGGSRFLVCTRNAAQATKLMVAEGFMLRNERVAVEAVGPPITFVNVFRYPAYLPDDPLTNALAQFGKVKSVAFATYNRQNKLNGVRVVRMEMSKPVPNFTTVAGHRVMFEYRGMRRVCARCSEVGHMASACTTPYCKRCGTFGHDTEGCEAECKRCGGKHGTRDCFRKRSYVAAARGLLTAHETASNQDRASVLNFSDGRSERSSLQVLHPRTPARTPSNAPTHRDTTHTVTSDTTNTEPSTLSIPAAQPVNAEDTGSADTRGDLALGSGSESSSPDSSRDSWVVVSSGPEDQASLPKGEETTDNEGHGAPEVTDESFPPLHAGNTRPPSFDDIPIKSCGRYIPPVDKARGTPAALPGPSRQSPPTSKAEVAPAPGKTHPPGQEQRHRSRSRQRSADGTEDRTAGKAANAETAPRRSGPPGGSSDSDAPARNQPKRPRKGSVGDGAPQPSDDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCB4</accession>
    <name>A0A9D4PCB4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_000044</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045742"/>
    <dbReference type="OMA" id="MSENPYY"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7934754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="298" mass="32753" checksum="D8EC228193CCB622" modified="2023-05-03" version="1">MAAPHSPRSAASASGGVSTSHLPSGSYSWDPLCNAHEEPTPQCLLRARRDIMDIFAAPPAGVFIAPEENDITRIEALIVGPPETPYEGGFFHFLVKCPPEYPNQPPRVRIMTTGGGQVSLNPNFHLDGEVCLSILGTWPGPAWTPSLSIESVLVSIQSVMAENPYYNHPQFRVELTPDDVCRYNDIIQHETIRVAVCDAVQACLDEEAAVEGVVSSCAPLPAALREVVFETFAESYDRYEAAVKARLDMTGCLMNDPFGITRGRYGYKTLLQRLRDLNDRIKRRNEISPGKNDQAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCB9</accession>
    <name>A0A9D4PCB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_012678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047155"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7935708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="497" mass="54855" checksum="A1616F2817D688AB" modified="2023-05-03" version="1">MSVGDMAKASRGNAESGFEVQLYVYDLSKGLAKKLSPALLGKELPGVWHTSIVVRGTEYFFGSTGIDSCPAGKTALQNPDRVVSLGRTELPHDVFLEYIRDLGKSTYKGSTYNLFRHNCNNFSQDVAMFLTGKSIPREILELPDEFLRTPMGNTLVPLFEHLAINVDKAPGQGSPGGVQQSSKGSRSPERSGRSKRSSPRGKTSGEKSPDGGSDEDGEDKSGDDQPVFYPRVDGIASFKELEKHLKKTTITDRERSQLDRLREYLVNGHGAWALGQELLDVFEKLLISQDGNCGARLSLLRVLQAVALFKDVVLFLHQDRKKHVIMSYVNRIATLSPQEQDEVLKLLCNLCSHVASCEWLLYISEWREDGGTRQVCSNAKATVRAAVCGLLCGRRLAQEFGAALVFNLTTREMFDDLAEQLTEAIAQFLKGDLSEEQVYRALAALHRLLRLSYNEVSAKVQSISPYLQKLAGSSERVKNLVTQISSKVSPPASVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCS2</accession>
    <name>A0A9D4PCS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_016930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038637398" description="Lipase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7936038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="414" mass="46160" checksum="E8EB1D732A2BD6EB" modified="2023-05-03" version="1">MGHMNAVIVFLVGSTLPFWRTRGARALMLPKDADADRSIEELIEIRGYPVESREVVTDDGYVLGLYRIPRGRLETEETTTGSPYRDCDGASRPPLLLVHGLLGSAVTWVTNYADQSLGYVLADAGYDVWLGNLRGSTLARKHVKLSPDSNISFWDFTFDQMIEYDVPAMIDYVLRETGNSRLGYIGHSQGTLIMFGLLSSVPAYNDKVGLFVALAPVATPVHAIFIARQQLLALSERPSIRSAVLKMGEILGQKPLWKKIADKPCRMQESLSLCESVWSTIFGPSVMFNVLVKTGRFCKYDYGAAKNKEIYRQTAPPCYPLEEIRAPVAIFWGHGDTLSRPQDVDRIRSRVSSIVVDERVGSGPFNHVDFIYGVDVKRVLYDRMIQVIGQFYSTCLTRSTSESTTATPHENAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD83</accession>
    <name>A0A9D4PD83_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD83"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37765" checksum="28392F1E65403ACF" modified="2023-05-03" version="1">MVTDPAKKPYDRIREHLMSSRHKKFKTASKEAETAGTSQQTLFDMSCRQRAKETEADGVIHDFVRALAYSGISMHQADGPLGDFARKYCKAAKTMPTGQRLRLKYLKEAFDKDMEKIRDDMRDVKVSVIVDESPDITGVPTINTLLCYYSQKNVKKHVVLVDVDRVNASNSYTVASAVSKALLTVGKTWKDVVAVATDSAEYMRKMVREICQTEGIQILHVKDIAHLIHRPFMFSCNFARRSIEGRLDFTAKSDAHNTPHGRRRGVRILPRGTRSEAAIFSVVTCRGTLQARKARGHMAKTHPSMPSHKRCSTQMHGTRANGLARSNLSERVFLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDE6</accession>
    <name>A0A9D4PDE6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_009986</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDE6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055416"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="97"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7935578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="312" mass="35100" checksum="82F016A0394010A9" modified="2023-05-03" version="1">MKLDTPATNWCDDEITAIGDELLDDEMEGPINEDFAPWMDTVSDSSDTDDDPKGRPVGEPAKWPQTTVSSTEMDRLSVLVLDDWDPFRFKHEEPSSQCQRRLEDDLLDLFNDPLTGVYIEPVAVGRFHVVMVVPSHTPCEGGFFHFLIQCPKDCPMRPPRVRLMNTDDGSVSFNPNLYKSGRVCLDILESSDTSAWSPALTIASVVVSIQSLLTEKALFNDPHWCSEERTEDCDSYTCVVQHETIRVAVCDAIDACLNGSSLCPGYLQRVMLQHFMACYEKYGKVVESNLDLTGAFMRDPLSSETYERGQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG37</accession>
    <name>A0A9D4PG37_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG37"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="15080" checksum="2BFDEE91C56B95D8" modified="2023-05-03" version="1">MPCVPYQPTRQYCKLCKSQGHRTDVCPTPMTKACSNCRLRDPPEDHTCEPECALCGGGHPTAASECTKKLKRVPQRGWPPLSHKHSTPQTTGLLKRRWNGDHKRAQAKQQQHKGKKAQNKKAKNKAQMRWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG88</accession>
    <name>A0A9D4PG88_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_021777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG88"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055450"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7940094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="370" mass="42536" checksum="749C950D0755618D" modified="2023-05-03" version="1">MTMTTERRRDKRDGVCYVQGCKSGYKSCKETRSLFRAPIEPERLAEWSRKIPRRDRPFDHACVVCERHFDERFIERTFRTKIKGEIVEIPRDRPLLTKDAVPTIFPEAPKYYTKKLPKKRKERNLCDQVRAKPPKRQEHSTVENACVPTSKEASEGLNCEPGSPQNEHVETTDDRLVFSRLRIPKGWSEITLVDYEGLRLYAQCEADVAEPYCSVVMLKSVRIEARQGGLDTAAAEVRLRGKIWCEQELTTREEAEELIDSIDKLLLCPGVGMQPLTRECPAYNGKFFSKDCTLFADEKLGRSCASCRYQRKLIQNQMGRRRKRGYEVIMTRASDMRWVVEVSPAGTTHKQVTEGVAVDSVEVFEEAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG99</accession>
    <name>A0A9D4PG99_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG99"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048848"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="100"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="399"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="509" mass="55824" checksum="75BEE097EDB991BE" modified="2023-05-03" version="1">MTADNRYLTVIWDRPHHTFDFYLLDVTVKSGNRSDTGRKPHSGFCANGTVIHAEETQVTCGPFDACSSITVTVRTFSKGPPEHTSVGATLKDVFIGGQGPSEPHSITMVSKTSHTTQILWGPPRGVDGILDVYNVKVCEKTTTCDEQENLTGCFESAVSHAWLEFNSTADTSYCVFVSATARCGENLLKGTRAAQEIRTPLFALPDVKNLNLVAAYNHYVTLAWDQPQVNFDYYWLEVTGGNALGNDSLEKHRPNSCSNGTIIRPEQTQVTCGPFDACSSVSVTVRTYSRGPPELTSMGITLNDLFIDGQVRPEVTNLQLGAADDDIFVLQWERPKTCFDYYTIEVIEQSTYKSSPVTCNNGSVINPSQMSVTCDQIKTCANVSIRPSSSAEPLTKFDLPDVVNLALLSSTENSITVTWEQPKTRFDYYWITISEQNRGKNATKEQHYMGSCSNGTTIHPSQNRVTCTNINACTNVTLTVHTQINGPPKRVSKGATMAIIFIAGQGNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHX7</accession>
    <name>A0A9D4PHX7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHX7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041441"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7943053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39530" checksum="36178D8E0EBE719C" modified="2023-05-03" version="1">MVWFQNRRAKWRKKENTKKGPGRPAHNAHPQTCSGEPIPPEEIERRERDRREKKLRKQLERQAKRLQQARLKPGVNLASLRETIQQSLTELWNTNPTKEPRALVGPETFRLLETLGFDVIEVLSRARFEPPRRQDVAPPSRSSADDSSSDVPAHRFMTLLTTTTPPGGGVVVSGGNGGGKSSAFSIESLLASRGGSREQAKHVTPLRLPMATTTASGFPLVVQQPMGFLVRPELQERGCDNDGDMSAERVQQQRQQQQRDCCSSADDDFSDPDVTGCDDEDSASRMDTRQTSRRERTADDDDDVSVGGGDVRVDDDCDVSLREERNRDPASDDETGSVHVAVDDDGADGDDERDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIF1</accession>
    <name>A0A9D4PIF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIF1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="26194" checksum="F68181255B1331F4" modified="2023-05-03" version="1">MPGWRRLVAGVRQNQIQIQVSFGFVTLSARIRAVATAATTTTSTTPAPKLSNVSAPCSERLGTLMRRVLRGFPSRLPELWEFRRRRFLRAAVVGGLPQLGVDRMQVNCNLSSAQTTWNVKLRAQLDGICNLGITGLPRMYLRFTGPVVAKARFVAPLSEDAKPTLQELQIMSADVQEIHYQSVLGFEQPFVERASKYLLQRALREEVLGPLREAINAEIENPSPEPPTTTEDIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIK7</accession>
    <name>A0A9D4PIK7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIK7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="167" mass="19312" checksum="3BAA6E4FAB39CAF3" modified="2023-05-03" version="1">MLQHANAFNISGHRCWAFRPCLRSPPVRKDPVDITVKSTGCGVSESYSLKEDTKLVVQEKKVVNCPTSYLRSNGYRMRFGITSEIKRFDVRLHREFAIEDVKPATVKVYDYYEQECPSTEDGVSRSKEPWKVNEDGRRAQAIAPYIQPGSDERIFEYRVDSFLRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIX8</accession>
    <name>A0A9D4PIX8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIX8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11858" checksum="A7750B9FDFDEC0A4" modified="2023-05-03" version="1">MGYEQLVRFAGILGLQKPLHHKSFIAISRNVRDVAMDAISANLARSRELTMSEVGRDDIAIMYDDGPGSWCEHRRSEALGKPAPAHTPLLTKAQGMAILPIYKRLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ75</accession>
    <name>A0A9D4PJ75_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_010303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033890"/>
    <dbReference type="OMA" id="RYSTFHA"/>
    <dbReference type="OrthoDB" id="93876at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052467">
        <property type="entry name" value="Sorting_nexin_PX-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813:SF9">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813">
        <property type="entry name" value="SORTING NEXIN-22 AND 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7943713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="18892" checksum="4AEC9EAE035C877C" modified="2023-05-03" version="1">MIRVFVPTYRQVDAPNGRQHVVYCVEVTVSGVCHRMERRYSTFHALHKKVKRMLGSQAPSGFPPKRLRGLNPKLLEQRRAALERYLQDLVRISALSSQLLSFLEVPTPLSPAASNGSVDSDDQEFKPLHQPVLGFPKDPYLDTSSSDSLPDIVMQGVMTGLFGYDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJB5</accession>
    <name>A0A9D4PJB5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin carboxyl-terminal hydrolase 39</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">U4/U6.U5 tri-snRNP-associated 65 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HPB52_006958</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
            <tissue evidence="26">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJB5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033956"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000030">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="25">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="24">
        <location>
            <begin position="153"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH7943337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="496" mass="57108" checksum="D78294BEDBB9E795" modified="2023-05-03" version="1">MAAPPDAKKRKLSDGLKRGASTVEQPRQSRRNCPYLDTINRNVLDFDFEKLCSVSLSRINVYACLVCGKYFQGRGTNTHAYTHSVQVSHHVFLNLQTLRFYCLPDNYEIVDSSLDDITYVLRPTFTKEDIVRLDTSDRLSRAYDGTTYLPGIVGLNNIKANDYCNVILQALSHVPPLRNYFLREENYTTLKRPPGDINFLIVQRFGELIRKLWNPRNFKAHVSPHEMLQAVVLCSKKRFQITQQGDPIDFLSWFLNSLHMALNGTQKISSSVVYRTFRGGMNVYSRKVIPVEMTEAERRAALRTTEYDEKVESTGFMYLTADLPAQPLFKDELRENIIPQVPLFTILSKFNGTSEKEYRTYKDSTLKRFELTSLPPYLILYIKRFTKNTFFVEKNPTIVNFPIKDVDLGELIATNVPDAAEGTYVYDLIANVVHEGEPGSGKGTYRAHILHRGSGKWYELQDLHVTEILPQMITLSEAYIQIWERRRKKPMVSTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKC0</accession>
    <name>A0A9D4PKC0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053100"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="346" mass="37803" checksum="8969FF6C67CC520D" modified="2023-05-03" version="1">MQVAALFASQRLIASFYESEQHSRVLHSLFCLAHTYLLSGFELFTGYITQVFYANARDDADALVRAVRDEYSRLLARWPNHDKNVTVVADWNSTAVAFNAVDRTIRESGDGVAWPDAGSHEPLVTGDSLVKAWRLVAAAVRASSRYPRMVAVAESMQALSFYANVGKEFILMPYVFAFPLYDEDAAKVLNYAGLGSQVAQALGELFLAAYRTSSPPAREPVLEYTQCVLPDAKNARQDESQVMQVLSFNVLFDAYRASAQAGDKRLPGLEALTLPQLLFVAACYADCPGGGLPSPASFIAGVPDPWPGGEPRCDAMLRRTSHFARTFGCAPGKRMNTGAYACSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMI0</accession>
    <name>A0A9D4PMI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_011819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040961"/>
    <dbReference type="OMA" id="PLNACGE"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="159"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7947424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="433" mass="50295" checksum="333C14E3AF2E6CD8" modified="2023-05-03" version="1">MRVLRPLLPLAKLGKQVFAPARHFREGTHRLFDLDVEFYADVANHDLITKNLTRRGCVADLDEIRDLWEQLKGRHRSEQMRIDLSRAIARLPNMTHPEVLEREGDEPVVVDVIGEKRQMDFVPRRFEYLMSRLGLLQADPNYNVMYGERAYFFRGDLARMEEALINFTVDKLLSKGFTPVYVPDLLHPEHIEACGMRTTGVRNQVYRLRTNWGTEVCLAGTAEMGLANMYRDRCLDMSELPQRLMAVSRCYRAEISSTKEEKGIYRVHQFNKVEMFGFAPPGQSAVLRKEFVEIQKEICRDLKLHVQLLDMPPIDLGLPAYRKLDMEAWMPGMSKVWRDQQCFRTAPDYQSRRLGITCRQTLEGPPSYVFTTNGTALAVPRMLIAIVENYQQKDNSVVIPDVLRKYMDDKALMEQCGTERTPRSVPFYFMENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMS5</accession>
    <name>A0A9D4PMS5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMS5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028860"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="142" mass="15485" checksum="CC1548C1C6F6FA9C" modified="2023-05-03" version="1">MSDDERLSLTTAVSDEDETGEPRSGSRAAGSGGGAAAAASFNCTGAVRKAGFLSVKKWLLRRRHQVELARKRGWKGYWVCLKGTTLLFYPCDSRDGRAIDSTPKHLIIVDGAVMQPVPEHPKRDYVFCLSTAFGDAYLFQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ76</accession>
    <name>A0A9D4PQ76_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ76"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="96" mass="10745" checksum="29497DE11D445014" modified="2023-05-03" version="1">MSMHVTVEGKDITPEECLESGRTTAISKRKSQSQPDVNGRESSTQHSGSCTRAAGVVKKRLAAASRLPRLLREHFRIIVRPRGGMDIRKISQIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQQ8</accession>
    <name>A0A9D4PQQ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Complex III assembly factor LYRM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049335"/>
    <dbReference type="OMA" id="TINQIFR"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7951123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12163" checksum="C635E5D9F6C57D85" modified="2023-05-03" version="1">MSGSARSLVLNSYKSLHRVILQVFEGDPETIRAARVRVKEEYVKNLRETDSGKIEELLKTAKNVEKVLQTDLIRAVRNEKGNYEVQLKPHHLQDNATCKPHDANKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS68</accession>
    <name>A0A9D4PS68_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS68"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040281"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7952052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16871" checksum="691F49C7E74DDDB5" modified="2023-05-03" version="1">MEKKKINFSEEERAVLLDLLSRHRSVVENKRTDAASASRKRDSGKKIEDEFNSHHNVTPRKWTQLKKCGGTPPSSEMTDELQRVRDIASHIAVRLPNPCDSDRSWYDAGGSQSSNQLCTPVAALLSQTQDTPLRVRCYGSFVFFSLPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSC5</accession>
    <name>A0A9D4PSC5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSC5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050965"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12294" checksum="511F1DC5A2F958C3" modified="2023-05-03" version="1">MYYAYVRFVDDGKRHILPISDIKNFNPSHLKDFSPKKVYDVKWRDDVQDDFFGAQIVKLFDAENMASVADQDSSGAGTLSLGAAVAGTPTRVLFEEIDGQRDRQTIKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSS2</accession>
    <name>A0A9D4PSS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_023274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048939"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052116"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002494">
        <property type="entry name" value="GPR insulin like receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="121"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="485" mass="54613" checksum="F9375BB86E20B0A4" modified="2023-05-03" version="1">MALSGLKKNTFVGLDQVTTLNLRNNKLQYVEDGAFQGLKSVTSLDIQGNDIEHFSHEMFHGLHSLESLFSDSFKFCCLASPQVSFDYCLPPADEISSCEDLMSSPVQRSFLWVLGVVALLGNLFVIAWRLKTKNSNPVSSTLILSLGCADLLMGVYLVVIASVDIYYRGRYIQNSDVWRASALCKLCGFLSTLSSESSIFTLVLITADRLICISFPFSMVRFGLRRTYQLIAAAWATAAAIAALPIVIQPYFQGEFYARSGVCLALHITNQKPSGWEYSVAVFFCLNLLAFASIVAAYAYMYLSIRRSKTAVKRHAARQADSLVGRQMALIVLTNSLCWFPMIVMGLMAMSGVRIPGESLLQLTTNRPAREQSFLVGCKSRTYTKAEKEEARQNSQNLSNFRFFKIPKVRVHEWGKTRQLSQRRQREWIASLNRKGVADNPQKYKGHSLQWVLLALQGLSAHELHWHRHLIVVFSSSRTRNPFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT32</accession>
    <name>A0A9D4PT32_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT32"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="11776" checksum="78A1334320BA6B5A" modified="2023-05-03" version="1">MAGTVISHIGGALASFRIGPRSWGRPRLVGCSVAHECPPSGLQPKARTSTDKQADVATQQKADVVISAKEKGAGDAKTEKVSARTELSRGDRRRLHEGVQKVHHKDKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU41</accession>
    <name>A0A9D4PU41_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU41"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15907" checksum="B393CBB663B12638" modified="2023-05-03" version="1">MEVTAGVSVLPVHPACANTAGEWIGPHVPYDEELAKIAAQDDSLEPEELRDGHGVVSRKDTGSMSSRKGRSSGEVKETPEEETQSSQSSQSTSSSGQSNTAEKQKTRPPRPSTSRLQDVNFFLEEMKQLQAQKESQRVARHEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYQ3</accession>
    <name>A0A9D4PYQ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_008578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYQ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049476"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="11064" checksum="9713C8A055683DDE" modified="2023-05-03" version="1">MWPVYSTVTGNIGVHALPSETAVQNVFEAVARELFRNDISWGRIVALYSVSGGLAVDCVKLGHPEYVLGLVQALGLFVERDLATWISQQGGWAGWTSKSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYW3</accession>
    <name>A0A9D4PYW3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYW3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="15250" checksum="9F7FFCAE7C80416F" modified="2023-05-03" version="1">MGNYVTGGAPNVVSAVAIGEPSFAAGRRDGKKAAASLCGDKEEREDTPLILMRQEVHGFNLPETAPLSHSTIVAGTGAEMRHMAPLCPRKGRDAEFPPKTDLGPPRCASPAGRSSTLKSAPAAQTHTSGFAGPAAAVRPYGWSARAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZF8</accession>
    <name>A0A9D4PZF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZF8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="311" mass="33999" checksum="A91FDD6CB3726D92" modified="2023-05-03" version="1">MPPPKEHFFNVRTPPGTSVDEVIDALEGLVGIQDIYSVQHHGGFDFQVGVNSVAAVQTLLETGGLRLGTRTVPLVPVARQVTSVTCLYLPCYVPDNEVVTGLKSYGTTLRIEEARYKDRPSIRTGTRYIKMDMRLENPLPNFARVGGHRATFEYRGVRRLCRRCNQEGHFKAQCDTPHCARCGVFGHRTDTCTEPCRRCGGAHASVDCTARKSYSMAAAMDVDEFPALGTATAAGQTQRRMTTLRPAKRPKPNEDGPEPQVIPEKNARASCGHYGTNGTGAAAGRQTDRCADASEHAQRREAGGGRQPWPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZG0</accession>
    <name>A0A9D4PZG0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZG0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="421" mass="46065" checksum="2BA1D8AEC5E9F099" modified="2023-05-03" version="1">MDMMVQACTSVATDCEAASVVQIKELYKDLGNPPGNIDVIYVEPERVAKFTHCGWSRQKTIANSFRHCGFNRSGACSTSEAAVPVDDEPEFGSLELPGSFADYVGADDDVAACSEVSLDDSIETVRPDTAGTSDEEEMDDAAEASASVPTYADVLCYVDHIRRFACARDEIGDLLPDQAVYGFIKVEKKDCVNHVHKRMGAALRSLVDKKKAQGEPLGGKGRLTQDRIKKITNYYGWALRSHKNDVPGMKRAVEATLRHMSSTDDAPKHDLCPEGLDLVPLQSNSLPSFVCDALEPVFKRLSEETLLERCNDGMTQNASECLHSVIWDQAPKTKHASLHSAQRAVAEAISRFNQGLTKSSTAIAEKLGYSAGARAVRRSLEKDRRRICMSNKDHANRNATTSKLARRHKPAADSAYSPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1T9</accession>
    <name>A0A9D4Q1T9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1T9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050086"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7962945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21403" checksum="95D1667DAA8AC424" modified="2023-05-03" version="1">MLVHEAPGNVGLLDQALAIRWVHRYIHHFGGDNQRITLLGQDAGATSIGYHLARNDTPPIQRAILMSGSPFVPQPDNAGQRALLNGNGLADVLGCGSRRSLQDASERRRVVECLRKRSAYATVLAADELATSSDTVVFGPSKNRDFPWKLASAVLSETMLKRVDFLVGVSKDEGTSHVSELMQAFGLSADQTLTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q296</accession>
    <name>A0A9D4Q296_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q296"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046409"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18577" checksum="15B39541CA9646C3" modified="2023-05-03" version="1">MREVSRNKSDRAASQNKYADRCGDEQLPFERAAASSNVCRPQQRLQRQQLPRGCSSRCPPSPGSLRWLDTPHAVSVSRGMSGTQQLMLFDHDARVRQAYRRARWMNQAQRFRISLDMSDPKVQQTLQLAAQPFDFQVGGRAPPVHIAGIDPDIDEEDELQNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q388</accession>
    <name>A0A9D4Q388_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q388"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045506"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="344" mass="39733" checksum="C3E71FC6562D5A20" modified="2023-05-03" version="1">MVARNEGERLYRGLREAVTEHLTNKVRALLLATVDESFLQTLNHAWEDHQRSMRMISNIVSVSKAGVRLFRDEVARCADKRDRLREAMLGLVKTEREGESVDRASLKKACEMLIVLGLDSRSVYEEDFEVPFLAESAQFYAFLGQQYINTKDAFEYIALVEQHINEESERSKQCLDDSTVVPVVQVVQKELIGKHMKTIVDMEDSGVQHILNSSMTEDLTRLFRFFKCVQGGVKTLLDCVSKHLRNLGRSIVNEHGDSVSLIPEMMDLRDRFDYFIQHSFDDDEDAKKAIATDLQYLLGLTKKSPEHLASFVDDMMRKGIRHMPKQEINQILDKLWRYFGPFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q534</accession>
    <name>A0A9D4Q534_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q534"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043720"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22604">
        <property type="entry name" value="Kunitz_BmTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000004">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039708931" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17801" checksum="0758FE77793EB710" modified="2023-05-03" version="1">MKTFVLLALWGAAIGRVVAAAGDFDSQCLPTADPGPCKAYIPMWWYNVLSGQCEEFIYGGCQGNDNKYRTKQECEKTCAEGSVSPFACFAPPDQGPCHASITRYYFDNETQTCEEFTYGGCEGNQNNYETAEECKASCNRECSSLCQRVTCSPLQWLVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q549</accession>
    <name>A0A9D4Q549_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q549"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030330"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="21267" checksum="F8EE7B43B9FF7903" modified="2023-05-03" version="1">MEGENLVIIHAGLNDVLKGKSQNLQRQLEDGVRKLREASEGVHVTICTIPEVWGQSGGMERRVIEANCVIRAMSRQLSYSVMEVNKDVYEPGLRPFAQDGIHYSGATGRRALTVYDEPRWSDAVNPVLHYRSETPTHPVTISRSRHPGNSDKKLVTGGSIFQVLVGRSNGSFHGCPKTTMEIGRRRKMGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5C4</accession>
    <name>A0A9D4Q5C4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5C4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11039" checksum="ADF448F5CA900C58" modified="2023-05-03" version="1">MESVRKETLVTDERLYRLSGAGDPNCTHCSQPETLEHLLLQCVQYSDERRILVGSYRGQGLASNSVDEFLSPKAHGTIVKRALSALLEFLESCALSERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5N8</accession>
    <name>A0A9D4Q5N8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5N8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033939"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="36225" checksum="FEEF3798A7A2CC8E" modified="2023-05-03" version="1">MGEPSVVPSAMVRSAMPSGISRLYMDDDDVEPARNMTTMQYCTLCVVAMIIIGVFAYAFFLAFVKNRASKEEPPLMCSLDGHHVYRYPVEMCSYIIFLSAVIDLFKGSVDPLAGTEQQYDAFMKASKSGDLKKLLSFRYDDVNSMTADDISTGFVKVRSNVFHGVDFRFTQSNPTWLKLLTVEAVSKYSRELVTGGKKLASSAWHCIGLSLAAVAFQSSSDLDDDAVGVKRLSYCEFDRNSSERVTWDPSYFTRTYQNDLVVFEKDKEFSEKLKEVTKLSKSCVLLDDVFYDYHKCQCDKPNFKLLRAARRVLWGGSTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5S2</accession>
    <name>A0A9D4Q5S2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein regulator of cytokinesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5S2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051017"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57871" checksum="1E4A8B91E4957A04" modified="2023-05-03" version="1">MVRAKVNELTSVWCDVGIDYEPTRSRLERTRVHLSNLLNQMVDGEVDMKERLLKNIAQFTVDVHQLSSELDVPNPAIPDSLTILERESTIRERLEHLKEIKNYRRRERKKLRAKETELCAKLGMPASNLCSASVPSEKDLQELEKHVEALEQEKAVRSCTVSLLRKDIIAKLHLLDAQPQAQLEIQVIDDEDGFILSKDNIDELKAYLDRLKQLEEARRQELAGLLDQLALFFDRLDIPPEEQDRIRSSSNGLTPSILAASRVYLDEDDSEDISEERLALLEEQLKALKEFYSENKMIIAKAERHDALWSRSLELEKLATDPSRLTNRGGRLLLEAKERQRLQVEIPRLRKEIEKFITTYSGSNKIFAVWGKDFLEHLDAQQQAHAQEKERERLERESRRKATPSALGSSKRAYCGTPSSSASKMSRLGTSSATLASSRRLGTPVGKGSLAVRGGTPVGAAVRSIRRRSLKTQQKKLANGRQLFSNTGAEGAGPSTSTGAPLGGVSTMDSFAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q622</accession>
    <name>A0A9D4Q622_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q622"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="34582" checksum="1C29AC9A263A9B5D" modified="2023-05-03" version="1">MNDTKVSLQERDLTDDANGLSQTAEADILVEVPRREGGRPQRPDDTAMSLAGGGKARKADCAPGRAMRTPFLEERALHVRRLAPRCARPRRACNRCKPLQVLSLADVSRVVFANMNAPGGKRKRITLDQKAAMIKAVESGTKKSKVARDFDVSTSTLSTILSKQQSIIDAVAHASDEPLLDEPATPDGFATSDEVAASWTALRDAGVVPDSESFCDYVSADSEVVATEQLLDDDIVRAVNDPDETSDDDSADERADSVPKASNVPTASEALDAVDVLRRYYGAHEGGEDGMNIAAAAERAIVRIRKMQQRPITDFFAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q818</accession>
    <name>A0A9D4Q818_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q818"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051882"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="68143" checksum="FDC87DD8D3499DCF" modified="2023-05-03" version="1">MPEMVTVEGMDLNPDDFDGAGWTTALGARRKRDPAKNAAAPAAAKTTANTAQKDDFNARSRSAVQKVVAASRFLRLPKDQIKVIVRPRGGLDVSKADLVLLARALTMAAALTDQEASEDTICSNKVQNILVISTPVRSNAFAYAGIQKIHTKVGAFEVSAYVAAPENTCKGVIRNVDPSIEDHTLRSMIVNQRNPTAIEVKRIKNTHVVVILFDGLRVPKNVMCGTALVPCSLYKRQVDVCHACGRVGHRADVCHHSKEERSKCHNCGEALPNGAAEAHSCTPKCKLCEGDHPTGDRCCSKRFHIPYVVRRRRRQRQNRSEKEVNPDEVKDPADMHQEVTEGAIPKRRSSSRGRSRSRWRSCSTGRSRSSSKSAADGAGPTEEVRSRSSSRQPGKKMTWADMVGDSGSAPTTSKQGKAQPEHVADPRIHTLERENKALKQELAELRATLARLEGRLLKNTPPPIPQSSGTVVASCSSHKRRAVDIQTDDDTSDVDDFMSEVSEAPSNASTSDNKRHKKRHKTKMKCEEEDASPVSSIANARLALVVAGIFLDGALPRLAVFVQSVTTGTHRQQTSSQLVEGAEDPRQLNLELRSRTLPPVMTTNVDQPAPCAQSGSGTGVPRLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9H6</accession>
    <name>A0A9D4Q9H6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9H6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17194" checksum="2D9194A0C37951FE" modified="2023-05-03" version="1">MAQHAMAAMPCHALPGFVAASPFTPGTNNNTGTGMLAASHNNSGDFNGRANTPNPDTPGQSQMLTVLQESIRALTSAMEMISPHPARRFPNNPSRNARGQVICFRCHQAGHIRHEDDPDDEEFFDALDRIPEDATMPALRPRRSVVPHQRDDFVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9R5</accession>
    <name>A0A9D4Q9R5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9R5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043981"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="175"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="410" mass="44438" checksum="C0C4CA07D3BF9E29" modified="2023-05-03" version="1">MAADLKEFVHSVVEANSQDLCELSRFVWEHPELKFNEVQCHDWLTDFLERRGFTVTRRYLLDTAFRAEFDAPGGPEGPCIALLCEYDALPDIGHACGHNLIAEASVGAALAVREAMRSYGDIRGKLVVLGTPAEETGCGKELLIRKGALEGIDAALMAHPCPEDVLTVHYSAAQQLRLRFKGKAAHAASTPWEGVNALDAAVAAYTNVSLLRQQLKPNTRIHGVITEGGKYPNVIPEETEMVFAIRAPNAQGLIELRPKAEACFKAAADTTGCSLDIERKPAYMNVAQNSAIAETYRKHAHAFGVTFVDDVVKDTPSSGGGTDCGNVSHRVPTIHPLFGLRAREGAVNHTRGFAAVANEADSQPPTLRAAKVLALTVLDLLRDAELLREAKREFAALKLPSEEELQAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA59</accession>
    <name>A0A9D4QA59_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_007125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050833"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="369"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7972124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="686" mass="77355" checksum="2F3C02AA576B7A13" modified="2023-05-03" version="1">MEGILADKLLQEPAVNLCFHKDVFMRENFSVDTFVSEHRKRASLEKLRDDLVVHLKFLRSSMIKLINKDYADFVNLSANLVGLDKFIRNISKPLEDLKKEVNVPNTSFEAALTQAKTELAARRAVQEKKALLHQAIAVSKSVDKIERLLPSPDRMDRWTNEQVEQVAIEVNQVLFYLSKCKQVKLAGALAERVNAVTELLQRHLEDSFLRALKIDSQAELSSVLRIYATLDRVEAVEELFRKRIVAPALDEMVSEKVVQEVGLDGIYNQVMMFVSTRCQTLLDLTLGAASVAETNASGYAFLERAILPQLVSMLEERLPWVFNAGDPESFQRRFSASVAFLERLERLCHNVSQVESLRAQPCYMHFMAKWNLAIYFQIRFQEIACQLESAITQPSQRSKGDEFLLLCHEALWGALRRCWDEDVFLVPLSHRFWKLTLQLLARHRGWLQQYTTQSGIGEEASSGPEAGDGEDGAGCDTSVDLANPQGPVLFVMLHCDVQNVASKVLEGLDECSQLLTSLTPNISARLVSDVAKACCVQLKMVPDIPRLYRRTNREVPSKPSSYIQQILSPLATLKDLGTQNASLNWDPEWTASVLEEVTKQYMTVTKDVLVSVKKMEDSLKRLKRARDRTPLPEGAASDDDKIRLQLYIDVEHFGIKMEELGTPKSKVPSYGALMEIVEAARSSPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAI2</accession>
    <name>A0A9D4QAI2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAI2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036437"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="329" mass="36533" checksum="4B7A358AA3C0D899" modified="2023-05-03" version="1">MSGGDDNARNPKNLPALLNFCVQNTATEDAPSSSTASMDPERRKWLEEAISDMTVSPVEEMQKNLNVIKETLSHHRESGQAPTEEACCTLESALESITEYVGSIDYAKDFHKIGGFDVLEDLLCFPSSAVQSRACELVAELVQNNPYCQKQAAQCLKFLLHLVDATQEAVRLKALYAVSCLVRHNISVYLEFEKLDGFSALLRALQSDSLRLKTKAGFLLSSLCSQQERSRDTLIRMGFVEQLAAMLRHEPGPHREHLLSTLDTLVTECPSARDECRRPELQLQDTLRTGLASSRGREEQREEHDHSAHILAVCFADSGAGSGHAEMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QB21</accession>
    <name>A0A9D4QB21_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QB21"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040500"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029336">
        <property type="entry name" value="DUF4594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635:SF12">
        <property type="entry name" value="HABP4_PAI-RBP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15266">
        <property type="entry name" value="DUF4594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="191" mass="21706" checksum="26C2795A28D552CD" modified="2023-05-03" version="1">MHGKSIWADLQEDGPPPDPNYRFLADRMREGDADGGGDRGGSRRHRDNYGGQDFDNVRHAMRQDKALQRESGHVLPPKLAMTGRQRREYEQWKSDRAAIDQERMQRHTDAEGNFTREWDLHKELGPDVETERYGSPTVWADKQSGDEDGVVEVHKLGPSARRLTSAPGGCSHRWCCLPPEHHNHAIPGPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDB1</accession>
    <name>A0A9D4QDB1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_004640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDB1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049521"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF12">
        <property type="entry name" value="RB-ASSOCIATED KRAB ZINC FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7975720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14570" checksum="677C8453C4E96E35" modified="2023-05-03" version="1">MPAERRYMRTLETFPLKRQTCHRIQRAQTKTANGNNANSASNTLARWKSCFSTPVTHSQDLPFWCDNCGAAFTCQGELTEHESTHVDKNRFCCALCSKIFINSTVLRDHTAVHRRHPGYRCHLCPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE59</accession>
    <name>A0A9D4QE59_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_010757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039825"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="6411627at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7976281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="369" mass="42554" checksum="D697DDE603A786FD" modified="2023-05-03" version="1">MSLSTRDMNVINNLKISIRDKENQVPDDTGKVEKKQAPVARRSTTGVEDEPLLRENPRRFVMFPIEYEDIWRMYKKAEASFWTVEEVDLAKDLPHWEALKPEERHFISHILAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQMAIENVHSEMYSLLIDTYIKDASERERLFNAIETMPCIKRKADWALKWIGDRNASFGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLMFSHLVHKPSATRVKQIVCDAVVIEQEFLTEALPVALIGMNCELMKRYIEFVADRLLVELGCEKVYNSENPFDFMEHISLEGKTNFFEKKVGEYQKAGVMANKEDQVFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE70</accession>
    <name>A0A9D4QE70_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE70"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031380"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="13759" checksum="D74C1EA4F213E6AF" modified="2023-05-03" version="1">MDASVRTRLERLAQIVDPYRDTPRRIPATAVRDDAPSPDTPPSPGEGEGVCVGTACEVPTQKKILCCRVMLEVVAEGNNDCITRHADLSSFCLNAAVLEATFYILTDFDVQMDVELHKKLAALLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFE6</accession>
    <name>A0A9D4QFE6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFE6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047604"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15624" checksum="58151D0072CC3D16" modified="2023-05-03" version="1">MIHSLNSVKCVIGRPIATYDAHVARTLCLQTGDGDAEKIYVRVGGNVTLRCPDLPPQPGQQPPRHLTWWKEDRRLIEATRERVTVAPEAGARVALVPGHSALLFRSVVAEDSGEYQCVVNNRQGRRGIVRLYVQGMNGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFK7</accession>
    <name>A0A9D4QFK7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFK7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19363" checksum="1821071AD1302492" modified="2023-05-03" version="1">MHCGDATNVTKTCFGAPPRRGATVASNVVSVGAGAVAGCLEWRLSDRLRPREGQHEAVFVRRSEGYSPEEAMRKPWERNLHRADKALDDTSADAVPTILPNLASYLTKKAPRERPTRKRKQSGSVQGEKETEVAKKFNIPKSTLLRILKNKDTIEGAVKNGTFSSSGCGCGRRLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFU9</accession>
    <name>A0A9D4QFU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038414"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="161"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7977039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="290" mass="31833" checksum="00FE46AEAE362D30" modified="2023-05-03" version="1">MNSHKRQFLALAAVLLANVEDDDIFLQAAKRHKKENAGKKEPAAASKQLLVTRLNAGPHDYMDLLCVSREQFLHLMSRVRMGIVKDKTVANRHVSAQTRLQVTLRYLTSGELPESLRDQFKLGRADVGALIQKTCNKAIYSNKAQLPEAIKVESSPDVLLPPVFIADDTLPLERHVMKPFIGSNLTQEKRGFNERLAMVQQVANDAFGAMESRFGCLRTVIQEKPERVAAIVNATCVLHNFLGNHVPSPPGASAKASSGTEVFFGFPSSCGNTSVDGCATRDVLTAFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGL7</accession>
    <name>A0A9D4QGL7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGL7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045272"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000001">
        <property type="entry name" value="Transcription elongation regulator 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000029">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7981685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="23881" checksum="201C7F2DC0C70AF3" modified="2023-05-03" version="1">MLCVSRLEEGEEGAAEGTEAQNGATETKTEEPIMTALRAQGKESAMEAELRAAKERAAIPLDVRMQRFRDMLVEKEVSAFSTWEKELHKIVFDSRYLLLTSKERKQVFEKYVKERAEEERREKRNKMRERKDQFQQLLEAAGLNSKSTFSDFAQKYGKDERFKNIEKMRERESMFNDFVQELRKLEREERLNQREKVDLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGM5</accession>
    <name>A0A9D4QGM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="6">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_002326</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="6"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031362"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000135">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="478"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7981974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="841" mass="94556" checksum="436419890A3C282F" modified="2023-05-03" version="1">MSRYRKPLTLGEKLRIIEEAEKRIGATKASIARDLNIPESSLKTILAKKDSILLNAAKFGLNRKAAKDGKYAAMEKALVECEAAVPVDDEPEFGSLELPGSFADYVGADDDVAVCSEVPLDDIIETVRPDTAGTSDEEEMDDVSTYADVLCYVDHIRRFACARDEIGDLLPDGSGDVKYHLGMSHERLNRVSNRNIKLAVCANPSHLEGVDPVVQGKTRAEQFYRGDTQGKKVMSILLHGDAAFAGQGVVYETFHLSDLPDYSTHGTIHIVVNNQIGFTTDPRVARSSPYCTDVARVVNAPIFHVNADDPEAVVHVSTVAAEWRSRYGKDCVIDLVGYRRNGHNEVDEPMFTQPLMYTKIRKQATLLDIYSRKLLDEGVVSEKEIEEEKERYESILSEAYKNAEKEDKSYNRDWLDSPWSGFFGERDPIKCDPTGVPEDILQHIGIAFSSPPPGNFKIHPGLRRILKARLEMVEQKMADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQTIDKTTYRPLCHLWPDQAPYTVCNSSLSEYGVLGFELGFSMTNPNALVMWEAQFGDFMNTAQCIIDQFISSGQAKWVRQSGLVMLLPHGMEGMGPEHSSGRPERFLQLCSEESDVFPTIDEDFAMRQLNEINMIVANCTTPANYFHVLRRQIALPFRKPLILLTPKSLLRHPEAKSHFSEMTEGTSFLRLIPDSGPAKDNASAVRRLLLCSGKVYYELTKERRARNLDSEVAITRVEQLCPFPFDLVKQEIDRYPNAEISWVQEEHKNQGFWYFVQPRLQTVVAHQKPIQYVGRAVSPSTATGSKHVHKKESEKLLNDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH27</accession>
    <name>A0A9D4QH27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_001806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH27"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7981925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12346" checksum="E584C1425BA83D99" modified="2023-05-03" version="1">MAEGASTSGTRGPRVSEGQREIVLAFMEEHPQLVSRAVELGPHFTVADRRRLWQQLADALNAEGPAQKRTLHRIELSTTRLAIAAERTAAAQEGILQELRHLAEALREREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHG1</accession>
    <name>A0A9D4QHG1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_000455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHG1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051577"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7981656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="331" mass="35979" checksum="1AA42073E63AB0CB" modified="2023-05-03" version="1">MRRIGNPPAAQYYGDITIGTPPQRFRILFDTGSSDLWVPASNCIEGDHYCPLHQRYDASLSSTYVGNGTRVHLAYGSGPVAGSIGVDVVSIGECPVRDQNFVQVDNSQDRAFAAAQFDGILGLAYPAYSVFGATPVFDNMVAQGVVHRPLFSVYLNRGAAAGEGGEVYFGGIDADHYTGELVYVPVSKKGYWQVSADSISVGDNNFCPGGCQVMVDTGCSTITGPSGDVRRLMKILGATPYMRDLNQVECRNTSLLPDFTINIGGKPLILKAEDYIVKVKRDDRISCVVYIKGYDFGAGRGPLWNLGDPFLGRYFTVFDRENDRLGFAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKG0</accession>
    <name>A0A9D4QKG0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKG0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048681"/>
    <dbReference type="OMA" id="QNAGHNR"/>
    <dbReference type="OrthoDB" id="6514255at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038386170" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="131" mass="13355" checksum="F67E6CA2466BA71E" modified="2023-05-03" version="1">MKTIFAFAATLALLGLAVAAPAEEKKEEDVEGRIGFGGGGFGSGFNRGGSFGVGSQGNRYGQGGFGYNVGGSNRRDYGNAATYGDRESFGLSQNAGHNRQFGQGSYGNRHHNNAFGAGGNRYASGGGGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SLQ8</accession>
    <name>A0A9D4SLQ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_024944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001759">
        <property type="protein sequence ID" value="KAH7932045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SLQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044486"/>
    <dbReference type="OMA" id="DFIFQAT"/>
    <dbReference type="OrthoDB" id="6489278at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039745196" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="28"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7932045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="542" mass="59700" checksum="D6E49257A9773D42" modified="2023-05-03" version="1">MVMGTALLAWLVASVLTATADDALVERQTTEGTVRGRVVRVLNNTVEQYLGIPFAQPPVGPLRFKPPLPKTPWEGTVDATAGNTACPQVLTEGITLGNLSFSEDCLYLNVWVPEAAKSPGSLRPVLAWIHGGAFTLGSANQANYSGVFLSALGDVVVVSMNYRLGILGFMSANSPEAPGNVGLLDQNVALKWVQRNIEHFGGDPERVTLFGESAGSMCIHAHIMSPLSEGLFKRAVLMSGTMYSLDTWDTVEESLAKAEKVANVVGCSSGGTIELASNAEEVVHCMRNKSADELLKASLEITAPKLAPFAPTYHDEFLPRNPIMAMKRGFFSSVDVLAGVTSDEGAAFLLFPVVRELLAEDLKDFPQEELVKSLRAALWRLLKDDVPDVLHTYTEEVAEGDNTALRRQYIDYVSDRVFNCPLQFFAEYYSKWGNTVFSYVFAHKSMIFPLPAWMGVPHGTDVAFTFGYPYAADPDSPDGRMTEAFIRMLFTFSENGIPEIPNNQTWPKYSKSSPNIILINNSQFNQSEGFRTSYCERWRHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNW9</accession>
    <name>A0A9D4SNW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_008766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055264"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7939219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19374" checksum="EDECDA68F7DC91E2" modified="2023-05-03" version="1">MTVHITATGGEEDETQTMAKASPGLRTPSAHSLTSSNLARPEQTKRFHACDVEGASRRLPLCARSNGARCMTEHASAPRGLSLVRSAALAVVCVIVLLGSLYVYICRDFCVSRVCGTMGRCCVPMCRGNYDGGAKVRLFSFLSDPKRRAEWQRAVRRDDVDVAQLKDPKQEATNRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQG2</accession>
    <name>A0A9D4SQG2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQG2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029039"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13292" checksum="744A7A38BB0E17E1" modified="2023-05-03" version="1">MQYLHTVNERVCVENIDAACKCVDAVRRRLRRHIFVHGVAKADLQCLDDDCSAWELHSGTIWGLERHSYDGIPWPLKTPPDDGDVDDVGSPARFNVAVLMHDVSFGASHNCTSSTQTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRC6</accession>
    <name>A0A9D4SRC6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_002742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054443"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="6">
        <location>
            <begin position="169"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="7">
        <location>
            <begin position="453"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="33"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="391"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7942967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="561" mass="63538" checksum="350D9F4AFA26B450" modified="2023-05-03" version="1">MLTDILDVEEIELLAEASRAKLESYVSLNTKTTEELREENAQLKARCERSSFQLEAALSEHRAQVTALEDACERAKQQAAQLASELGTCRVELEGAKATTAATKADLELSKRNLEQVTKEKLELLQAMEKRTQELSSLNGQVESLQSELSSSQQQQREQAVRLEELQLQLLSAQHAEKRLQQERELIQAQVEELREEASAHRQEAAQLRRSKAGLTLDLQAQLDHQKEQVSSLTRQLETWRSSVAEMEERSRTTATLLDEAREAKANLEAHFQTELQAQRRLVDMHKELSENRRQRIDELVATLEEMQALLLETRAAAERSQEALKECQASHEEELTKKEAIIESLRKELHLANCLLEGKGSVVEKLFPAAHVSGLARESGLSLTELLSERLEQQRALTQAIREKDALQQQLNELSQELADKEYEKAVSCVATLREQLTGALVEQEQRAQERDEARAALAHAQRELRRWQQQAKDLSRQVCQLIREVEDARGGGVPLSQEEVSSSNDDASPPLTASEVISKHLVTFRNIEELQQKNAELLAVVRELSEKQEEEEKKAAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRE6</accession>
    <name>A0A9D4SRE6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_002028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRE6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032913"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7942851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="412" mass="43146" checksum="E05895B5A637B8F1" modified="2023-05-03" version="1">MYRYCNREFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDKVPNALPNKNSVDIEIYGMEGIPEEDIREHERQKQDRGGGSGDEQDDDRPAKQPPPQASTAQQSVLQAQQAAAMAAAQMNPALAAAPMGMAAVMQGHLGHMHPAVMAGMPGMPPFGAPPGMPPGMPHPMAGAPHPMAPHHMAAMGMAPPFMGPGHMPGAPMPMMGGLMPPPHPAPPAQPPVTQAPPKPLFPAAQAVATATTTATKPTFPAYSTSSPSSTTGSSTPSSTTEPASSTPPTSNAVVSAPPDIKKPALVVPAGASSKIIHPEEDISLEERRMRLPQYQTAETSQPATKSTASPSATASPTVNGALRPPVPMPPPGMAPGMPPGVPPVPYRHAGAPPMPFPPQPGVTPPMMPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRH4</accession>
    <name>A0A9D4SRH4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRH4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030622"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="37548" checksum="DC946EE5A2C1FF33" modified="2023-05-03" version="1">MPARSESTDGSGSSGRNGSNDTLPAADTWGSWHAAGETHNRCLQFRVKNGHARVSCLLCATPMGSPRWLVPFVGRRLPRELAKRLTQASEPEQVQAALCASLQAVHDAWLQSLEPTLSRRDELLQATDQGPGEASLAALEAELSSGCSLALAVVMDGEQLYVANLGRTRVLLLHGGEEPKLLTVEHSVDNADELARLARLGLDTDALTDEVLPVTRCLGAHPRRRRLSGPDPVSNEPELCGPLDVEPGWRLVFLSDGLCSALRISGIANQEANRLVAKLALQPGSAREALSQLLYRCELPASWPHELTLMVVSLCEEETPARAPPMSDGRVDPYVDFTPLINALEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRP9</accession>
    <name>A0A9D4SRP9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRP9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10747" checksum="4FDCC7886ADE25DC" modified="2023-05-03" version="1">MPRLRYVVGVARLTSFNESVLEQVDSSGDIGKSWCRRGRKSFEAKCVLCDLGLIKGGLANKNMEDIECGQVLLADANDSLTENMTRLADINQELQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRZ7</accession>
    <name>A0A9D4SRZ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRZ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="61" mass="7063" checksum="D5351619D87ECE62" modified="2023-05-03" version="1">MDLPKSPFSGSRLNYRAPCTSSEGRLCDVFKELPLWNEYFWPVGFQLRELSPGQLITRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSX8</accession>
    <name>A0A9D4SSX8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSX8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027493"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051946">
        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01424">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7947911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="14678" checksum="5FE1F2D5579EEDF7" modified="2023-05-03" version="1">MLHRYRAGNRPNALGDLVQKTCLGRAGGWAFLAHVVSGERVSQMTRTYSDPEALTRLLEEKERDLELAAHIGQGLLREKRELACRTDALEAELLQAQESLTQLRHELALKASLLQVYTAQEEADAALPSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU85</accession>
    <name>A0A9D4SU85_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003960</name>
        <name evidence="5" type="ORF">HPB52_008952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU85"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7951429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="454" mass="48014" checksum="199C148A487D5F92" modified="2023-05-03" version="1">MAFRAPPPKAHCFSFNTPTDSSADDIIDAIEEITGPRGLKSLQHQGGTKFCIAVATAAAAGKLSARGSFVLNGAAVPVAQIGPQVVTVTVFRCPLFVGDASLAAAFAQYGKVLEIYEQTFKGRQHVGNSLRVVRLEMSKPVPNFMSVQGHRVMCDYRGVTKVCSRCAQEGHVGKDCHTPRCARCEAFGHDTTGCSAPCRRCAGDHATADCLQPRSYAAAVGERPEARGRTVATEDETRGQDMAAPNEAHEAQARETDSSPEEARVKDWSTWADDASSSLPAERGTAASTDAESLSGLSQAASTESESSGTSTCHSAKASQSPSPSGAESAPSKAPSVKHTGSQVAAGRGHRTHVVDSPIRRTTTEPASTPQYQQPLSPISQAVKQSRDPSLRNPLYQLTDVLGQGDNMHVDKPDLKRPHYSSSSSADEPGNPRKLPATETSRPGDLPGPETQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU99</accession>
    <name>A0A9D4SU99_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_010130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU99"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056266"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="507" mass="56286" checksum="A35CEA4AF1E674A0" modified="2023-05-03" version="1">MATAMQVTVEGEDIGPAEISESAGWITAFSRRKSTSSRQTLQPCNVPRGANKGAAPASVRKRLTAASRLPRLPTEHFRVIVRPRGGLDIKKTGHFKIAQALIAAAGLTSGEVEEDVICPNMIQNIMVASTPSERNAKAYNTVASLIIDNVTYEVNAYMAAPNNTSKGVIRDIDPTLDQDELTRLIVQPRNPTVIGARRIKSTSSVIVLFDGLKVPEYVKCGPSLVKCSLYRRQTDICYACGRLGHRADVCPSPEDGICRGCGTSNPDDQHNCSPKCALCGGNHLTASRDCKRRFQVPYVVRQRRRARRYQKSQEAHDSTGAEPLPPKSATSRRSRSSETRGNRYRVLAEDNSPSQGRASSKDKGRSVSRGRKGYKPDSRSNGRSPSRSRSRSIGRSSSRSRKLSVSIQEPAEQGTGPTWADRVKGQTKKQEMPVDWRIHRHCFTGEWKEAQQWLDAFPNLCIGLTPLLGFRNADTLVRLAARSPWSTCCWRRTCRTFFQTEYVQYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVF6</accession>
    <name>A0A9D4SVF6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVF6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028299"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="22897" checksum="189FE32EBD275EF8" modified="2023-05-03" version="1">MPVVQLEPDGMAEDADQVDASAAASADCPPPAAQGDGGLPPSSSASANHDSSSSSSARALSGHVKLLRPVMVQASVVPESPPSSPNVDDDAPPLQIDEDAPTPPSPPSTSPHPASPSPPSDLVVTARHDVVLRGGSVWRDHNVEGIANDNRNNGNQRKERRRSGEPPSDAEEARIREYLCRSDTAVIYPEPVEAASAPAVAAQQQATPRLAELPSTPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW21</accession>
    <name>A0A9D4SW21_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW21"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21611" checksum="6E35ED2C7CE25FA7" modified="2023-05-03" version="1">MNFVQELIRPVIREELQNLSVPSPPTIFSSSSVVRDDVQHALMTSPACRMRKICGNLSHAIPLHIAASAMLHTVQATPYYNDHRSSPRKLDLGMSTGSAHVERLDDGEGIHRDLDSASGLLESKSMFRPGARIPSSLHLPPRFQCGSFSFIAAPIRVACSVDHPMPAGKPSHRELPGRGRVYWTDSRSSIDIYENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWL9</accession>
    <name>A0A9D4SWL9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWL9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048180"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53123" checksum="E797D146A79D3403" modified="2023-05-03" version="1">MKVWPRWIWSYNLWEIVDDGGAIGDIAVAVMLCMGVTAPHLVGIGGGFIALFYNKSPSAAKPDIFSDAALYKYGATASIVPGAVEGYGRIHKELGELEWYRLFDPAIRLAREGFTIGPYLGQTLERHSANIEANADLNDLAIHGAQYMYTGELAKDIIDSVKQGGGIMSDADLSGYTSEWTKSVSVNLSNGLVFQSAPIPGSGTLLGAAVAQISLDNAIFNDPGDTVSQMTAGDLHRLVERLKFAYARRADFGDEEESRNNEYQIFTEIIDKINKTYDSHRPLADAEGYGLKHVFAQDYGGAHVCIIAPSGDAFSITSSLNNEFGSMFTTSSGLLLNNYMDAFVKHASEGAPTANLLGPSKTPMTSMAPVIITKVSSITPVHSVFGGSGGMAGVSAVAQLLTCASKYAYHECALNEARVHPELVSMKFVVNVAGKDKDLRAKQKLKSYGHEVSERFIPSTAIGIMPTRRATYLVLNDTKHIDGGNTGGSITNPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWT9</accession>
    <name>A0A9D4SWT9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWT9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032207"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="18594" checksum="4EB9A9525ABF458F" modified="2023-05-03" version="1">MWYYIEGENIYERQKQKKNSLNSRRRAADQLAFLPADIWNNLCILAKADGSDSSCRMTLPFRKWSPFGNLCAQSRPTKLLLHQKTGDHRKFASARVVATEKLHQEAAALQERVAQVRPEIQGLASKVKRLEEDCARKSRQLDKLAQTAKDKAAAAQEKKEMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX33</accession>
    <name>A0A9D4SX33_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053469"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="28"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="117"/>
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        </location>
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            <begin position="193"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="816"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="925" mass="99198" checksum="50C0DA0CE18B7EA5" modified="2023-05-03" version="1">MASLSSGKRPKKTTTTTTTTTEAPAQESKSEEASREEEPPKAIEAPEPQPSPAPQRPSSILRPRKLHRPPLAHLPPPGQRQTSVQGPPPLQSPPLEQGPQLAQFPIPEVRRPAQLQRVATDQQELPQAQRPVQGHGAPQVIQRHRRPPATAAPPPVQERQPQGPRDIEVHRAPQRFGSAQRQSHVVREPEVQRAPTTRAEPAAEPYVPPPSLVDSTHGISGGTNFGFGMRLSGRRTSQTIVAQSDQSRDPEVQVEERPTASPRHRSRYHTTRRTRRPTLSIESEFPEFPVTRAPHRAAAGLPSKRRRVKVSRPVQLPQVSTEEITTPAPTTTTTPEPPPTTTSSIATPGTLPVVTVPSAPGLVTPVFPSAEQSFYRTHGLPQGPYNTYGQAVTLPQQPFTQPSPFTPPATVADTPAVTAAPRETPAPGDRESDASPRRPVDQPSAVVSQQGPLLGQPGAFPLPPRSQFGQPSLLPGQAPPHLNSPFPQRPIYQLPGFNPGQSPPVPQHYFPPLGAPFVPRNSTFVEDVPVPGQPRVPEGSQAPPQRNRTSEAFPLPVQRSFVDASVAAQGGFGQQRPALANPYSAVQPAHVFGPPPGSVPTFGGFPNQFPGAPFRGAPTPELVDPQFRGQTSLPLPNQAAAAASQTTPSQQRNSFVTEATPGVTQANDLGTTPLSLSSPSTAAENQYVDDVGTSLQLPTATPPSASSLSTLNGERTTSAPFEYQTSRPSVLQYQTPSRPSEQFATSPAVPLYQTTPRPAPQFQQSLEPQQRTTPAPQSQPSSPGAPPSSQSHFRLGTSQQQQQNTIGAQPQFNSIGGAQQGYDPYQQQFGGGYQVGNNLFSPVQQTSQDLGGGYQYPDSGPFQAQFGGPYQPQYTTVDDYSQYQGSAGLGDIRGSGTNQQGYRATTPPAFDSRLLSYDIGVPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9D4SXU9_RHISA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005780</name>
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    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
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            <taxon>Rhipicephalus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032592"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="264" mass="28579" checksum="5CD9D20E243A1025" modified="2023-05-03" version="1">MLFFHCINNAVVNSFILFETHREDHRNIEELSGKTGFDQLAFQIGLVNQILDMDDRHVPPPPPPKKSEHKLQDSRHGFKLSALVKEYELAQSTISTILKAGSTTLLKAGTSGHADKRKRIREPCGSCLTIDRSAPGTSGNADGPSDAPNLKISLLKAVRFVTARGTRTSLPRLVTAKPGTETADLTELWEHVATGDADSGCCRTAALCDSSDSSDEEVDSASTTPSMTTQGALTSIDSLIDFMHIKGMPPEFSAAAESYAHQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0N0</accession>
    <name>A0A9D4T0N0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Parasitiformes</taxon>
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            <taxon>Ixodidae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0N0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045497"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="641" mass="72206" checksum="E0315CCC41A2C0AB" modified="2023-05-03" version="1">MGMRVVYADLPGGPTFVRLADEISRYSLCAKCGMLSLSLYHDPAGHVFCKTCLVEQCTKQRRLYFYCSQESKVVALNEMIKAHHLNAALGALYVDCPNKPDCQMKMRLDELNDHYLPCKPRYECPTCCRSVETKNWREHVCVFESSLSGTWTTVSGAFNFFFLLLYALCLSSYLFLNSLSSVKHPITLRIIYVDVITLMVVFVHFCNFMYPTAFRKPLHNLGQHKKVNKTAKRTASLYQRRRCANISTCRRVKDNNMPRHLRNCTKAPEPCVYCEAPFRPRDMTSHIQNCFMNPDNATKVSSSQCKSGAAVPNPLESDSSDSSHADQYPPGDGPIWLQYLASGDWLGAFMTMEESSNFRKLEEHDRHARLASTLVYLEQHACVRDFLKQPSLVQPFDSLLAALFVRAYYLPRNVWSKREEVTWERALACLPKSLASRLGGEAVHYLHAFPVFLDEKSAQGVAANKVRPARSQPRPNPESDSMSEPTASGTSGEASEREKETEMETSEPDLAPCRKPKERKPFCERLPPGTTGPPLPSRMPSDTSSTWNENVYDDVEVPGYRKSYLYLRDKDGFADISYETVPELDNVEMTTSRGDKEHGVSPGAKDSAAADGAKPKAVADSTKPASEEEHIYEDIDELHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0P9</accession>
    <name>A0A9D4T0P9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0P9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15317" checksum="4EEA107EFBA11888" modified="2023-05-03" version="1">MGYQSARYHVEPPDVPLVRARTCGPNFLAAAGSAHLCPGKNIGKNVSGFMTAYGPSLARTVTTRYSSRPQELEENCAVCGLHFHDRFISRYYEHTVNGELVRIDRTRPVLLPGAVATQFPNLPAIAQRGATTGEKAPYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0V0</accession>
    <name>A0A9D4T0V0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0V0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10257" checksum="DD3FDCDC36A48F7C" modified="2023-05-03" version="1">MAVPQPSQPPAMTSMPLVEPPKFSGLKDLQSPEVSLGCLDSFCLVSGIDEAKRLSNVVPAALEGSAELWRRFVGAFASCGEFAQAFCRDLLSTPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0V1</accession>
    <name>A0A9D4T0V1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0V1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056297"/>
    <dbReference type="OrthoDB" id="6503484at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038449886" evidence="1">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18740" checksum="07E6F6B73B2CCF42" modified="2023-05-03" version="1">MRSVFAAICLLGIVAFTANAHALPEQKPSVDVAFKSAAQEALYLGEILNDAAEALTEDEELKAASDEYFIRDLWSKAKEALKNATQKATSSVKGAYDEAKEHLKKVANEAQQKLKEKAAEIMSKILTKIAGQYALEDSISRTDFMQILRDLIKGAAQRLFNVGKALGQLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T108</accession>
    <name>A0A9D4T108_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_014948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T108"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033049"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046881"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16906">
        <property type="entry name" value="YEATS_AF-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="700" mass="77874" checksum="79B4733544332C74" modified="2023-05-03" version="1">MTSPTKSIEVKLELGHRAVLRARPTAEGFTHDWTVFVRGPEGCNIHHFVDKVIFLLHESFPKPKRVLKEPPYQVSESGYAGFNMPVEVYFRTKEDPKKVTFVYDLYLSVDGTPISNIRCEKLTFHNPPDDFCHKLLKAGGVQNFNLPEIGAIVVSARLTWLEAPLWSSHHPPPPLPPSPPPPVPHNPMADLFSTPAAKKEMPPEKSSKGKEQKSSQSKSKSSKSHSSSGTSSTSSHKLSSSSGSKEHKSSSRDKERHKDPSREKNKERDKSRDTKLSSAAEAEAKVPEPKLPESKGSSEVDSRRAEKSSQKHRDKTKDKSSKERSSKEHGPQKESTHKTSSLPPPASTESSSSKSSKNASAPRRPLSPPPPKKPRLQEPERKKKDSSKTHRPKDSPKKPPEHPDRKPPEPSEKLPSPLLPLPASPPPVLPVREPSPVHATNQSVPAPPPVSEESNSPKVPAAPARGPLNQLMLEMEQEDLLSPLSSPSASPTPTREVVAPIAKAPPPPSAADHLQELQELKKRILNLEDPRRLQAVVDLVEGTGLYKMTEESFDFDLCTLDKMTLERLQACLNGSAIFMPEKTTIYTTLIGLLNARNYNFGGELVELLVKNYKERLKDCKFEDARIIVRVFADLVNCHVISVGSVVSLFESMLEVTLEENIPQVRSDWYVYAVLTALPWVGRELYEKKDQELDRLMRHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1B2</accession>
    <name>A0A9D4T1B2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_003271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1B2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032496"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040178"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="664"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7967860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136604" checksum="A27F835F111BE4B6" modified="2023-05-03" version="1">MFSGSVLLPGGDATGDCTLRTLDGGSFEAQRAYLSTVSPYFAAVFREQFGAQRDVVVSGVSAAVLDALLTFQYTDQLCVNAHNILEVLRAADMLLLEEARKQCLMLLLKTMGINNCLGLATLTRQYYFPNFSDTVFAFLRGNFDEIWQRSEEFPDTPAWLMYDLLSSPELNVEREENVLHAIAKWWTSGSSAAAPDANVLLQLLQCVRIGRCGKEALDQFATRWPLLVDGAQYQAAIVQALRIGPCMCTPNKLLRALTEPENPPQPAPPANMAPNPAVAAGMAVNEAGNPVIAQMAFFNAPVMFGQPNPLINPAAMAVPAAEQEPEPEYVPMDLRQASCEQCGLTNPERWLPRLPSELIVVFGGWSNGQPRATIETYDPRVNRWFQHKDADFTARAYHGVVLFRRRLYVLGGMKLRLYLRSIESYDLDRGQWNHHSPMHVPRAYVAAAALGEHIYAMGGHTGVERTSTVERYSVRTNQWTMVARMMRRRSDGAACAFKGRLYISGGFNGRKVLESVEEYNPSLDAWSLVRPLPYPRCSHRMFNHGGRLYVIGGFDGRRRLHTGTSIVASVECYTPGERHWNKAKPLNGPVSALAGCVLSGINVARKFSARVGAVRAGVSGNGAAGGWHLGRERTTPPRKRRRWSRAAAAMFSGRVLLPGGEAAGDCTLRTSDGGSFEAHRSYLSNMSPYFAGVFREKFGSQKDVFVSGVSAAVLDTLLTFQYTNQLFVEANDILEVLRAADMLLLEAAREKCLTVLLNSMGINNCLGLATFTRQYYFPSFEDAVFTFVRGNFDEIWQHSEEFPDTPAWLMYDLLSSPELNVEREENVLHAIARWCTSGSPAAAPYGTALLELLQCVRIGRCSKEALEQFASRWPSLVDSAEYQAAITQALRLGPCMCTPNKLMRALTGPEKPPPPTPPANAAKKPARAAALPVNEAGNQLFAELAFAHAAQLQANALAAAQAAGPAAGPAAGPAAPVPALPKAPEPEIVPMDLKQACCQKCGLTNPERWLPRLPNEVIFIIGGWVNRQPRATIVTYDPRVDRWFQHKNDGFSARAYHGVVLLRRRIYVMGGLKLRAYLRTIDSYDLDSGKWTHHSPMNVPRAYVAAAALGEYVYAMGGHTGRLYISGGYNGRQLLQSVEEYNPSLDSWSLVRPLPYASCSHRMIGLGGRLYVIGGFDGRRRLYTGTAIVADVECYTPGDTSWKKAKPLKVPVTGMSAVVLSGINVTRKFSARGALLPPVNPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T208</accession>
    <name>A0A9D4T208_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T208"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="21865" checksum="96FEB11E8D27D94E" modified="2023-05-03" version="1">MRVVTGLPQCTPIPILQLNTINEWIYQRRQARQLKPSFLPPAADSTAYMGNQVSVSPPSIVTLPPCDHRQLTDNKLIGRLRNPVPRPTTTFRRHIEEAGAALPTGSLVAYTDASCTGTQVVTSIVVPGHQNLCVSRLYLLRAPVPSVSAELLAIRDATKLVSAASASSSSFTIIRTDSTSAIKVLHKATYSASLHRCLVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T254</accession>
    <name>A0A9D4T254_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3517 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T254"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029652"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3517" evidence="2">
        <location>
            <begin position="182"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="606" mass="69023" checksum="6231F51BB415205B" modified="2023-05-03" version="1">MEEEEEMKNQCFGGEYMGEVFDHMLKRMSYRRQKRWWNAYILFYQRTPLADSMANLSIQPKVATLPRMPAAIECSVWRQNIKFLHTRNQFSPEYFQFTKKLVSCNAPFVTLAPDQDRLTPEAEELALVSVQLASKFLFQTAFHTKKTLRGSASDWYEVLCVHLRHSRNVRLWFANQVLFAHPHRLAEYLLECPTTEVRSAFAKIVVFLAHTSARDGPYTPLCPISATVDQGGVSSLSAASLSDHLLVAVLSLVNKEVSEHGRHLAQYFGFFYMYACYGVTERLQLLRLNVLGTLMLVALDEGPGPPIKYQYADLSKLYQLVSLLVRCCDVSSKTHSCLPNAAPLPNPHMGDQLCQEYLMPIQPQVAACLYNKTSYVKKVIEDASGAEDTLKLLQFCSWENPQFSSAVLGELLWQVAYTYTYELRPFVDLLLGVLLLEDSWQVHRIHNALRGLPDDREGLFDTIQRSKSHYQKRAYQCIKCLVALFDSCPAAAHMLHANGELKRKWAAAVDWLNDELERRPYGAGSQYGYSQWSPPAQSNETSNGYFLERSHSARLTLSRAIQLCPEEEPEEAELTEEAPAFAPPSTLRYQSEEPHSKEDSRRTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T287</accession>
    <name>A0A9D4T287_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="454" mass="48045" checksum="13058D4742A1F437" modified="2023-05-03" version="1">MAFRAPPPKAHCFSFNTPTDSSADDVIDAIEEITGPRGLKSLQHQGGTKFCIAVDTAAAAGKLSARGSFVLNGAAVPVAQIGPQVVTVTVFRCPLFVGDASLAAAFAQYGKVLEIYEQTFKGRQHVGNSLRVVRLEMSKPVLNFMSVQGHRVMCDYRGVTKVCSRCAQEGHVGKDCHTPRCARCEAFGHDTTGCSAPCRRCAGDHATADCLQPRSYAAAVGERPEARGRTVATEDETRGQDMAAPNEAHEAQARETDSSPEEARVKDWSTWADDASSSLPAERGTAASTDAESLSGLSQAASTESESSGTSTCHSAKASQSPSPSGAESAPSKAPSVKHTGSQVAAGRGHRTHVVDSPIRRTTTEPASTPQYQQPLSPISQAVKQSRDPSLRNPLYLLTDVLGQGDNMHVDKPDLKRPHYSSSSSADEPGNPRKLPATETSRPGDLPGPETQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T341</accession>
    <name>A0A9D4T341_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_006880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T341"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046986"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="53"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7968203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="330" mass="38234" checksum="30E93CA46559621F" modified="2023-05-03" version="1">METQGVVNYTYGAKDVCLTFFYFLIAIVMHAIIQEYLLDKLNRKMHLSKMKHSKFNESGQLLIFCLASFLWGAEIIRKEGYLPSINKLWEGYPHNEMSFMFKFYFIIQLAYWLHCYPELYFQKTKKDEMSARITTATLPLIFFLVSYILNFSRIALCLSVMHYLVETVFHASRLLLFAERTKASDYGYAVWNVLFVLVRLASITLSVLTFWYGLAQQENAALPIGLATGNFNTKLIRVNCTVAVCLLQAWMMWNFVNFHLQLRRERAEAQQSSGPAAKKKAVARKDRKAKKDESTKRAADEDVNELPEVDQNAKKELRSRHLASPKAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T387</accession>
    <name>A0A9D4T387_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T387"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23192" checksum="8342F601555C558A" modified="2023-05-03" version="1">MNEQWPAYGPYDVKALRRFFDNKRRTYRLEKKKVETTKSGMASSEIYRGRWRFYNSLKFCDASKVTCWRSVSTEECQAAVETTKIPQAIDDPSGASDAVTAATDDQNTTVDDPIAAKACPATSRQGTHRKRRQSPHRLDEILAQRQNVLEKIAASVGQPASATQQEDDIDYFGKVVAANMCSVPKDKLIACQTAILNTLEIHIDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4B4</accession>
    <name>A0A9D4T4B4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducing adaptor molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4B4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041702"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7969602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25449" checksum="3D4C225D6A9D779A" modified="2023-05-03" version="1">MPFLGASSAFQQDVEKATSERNTSEDWALILDICDRVGAVPGGPKDCLQCIMRRMNHTIPQVALQALTGHPRVVEKMKGLLKKWAQEDFSKDPQLSLIPSLYSKLKGDGVDFGPEGGNLTGPFCALQSDSQPSEQLVSRTSTKQQQQEEQDLARAIELSLRDSPPKNSVSAGGGLYPRAPSPASAALAPESNSSAVVEGAPREPRKVRALYDFEAAEDNEITFKAGELLLVLDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4H2</accession>
    <name>A0A9D4T4H2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4H2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12232" checksum="350085A47D0C3508" modified="2023-05-03" version="1">MVTDPAKKPYDRIREHLMSSRHKKFKTASKEAETAGTSQQTLFDMSCRQRAKETEADGVIHDFFRALAYSGISMHQADGPLGDFARKYCKAAKTMPTGQTSAEIPERSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4P9</accession>
    <name>A0A9D4T4P9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4P9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033428"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="51554" checksum="D6ACA1B707F07897" modified="2023-05-03" version="1">MDTTAASRKRGRDDDPLECPRKQPTKDATAGDTPDGSPSTRDDSACVAAPPTAPLPSETTGDSVAATPAAPFRIVGGKRRRGQRKTRSKRRRKQRAFEPSTTVAPAAPRPANTTVTAPHPPPAEEDFVTVVSKAAQRRAKALAAAAIATDPAVAGTVLYRPSAPGGTFKGSPRLTLAAAFAMRPDVVAVRINHRRNIVAADASTQPCLSELLTIKELSGIPVTARVPADRRTSVGFVHGVDGEPSDKQLLEGITSTVPVVAATRQGSTVRLQFAGSQPPERVSLCGIWLRVRHARPRPIQCRQCGRLGHVTEACERVGNCLTCGQHHQATAVCRPRCVNCRGRHAADNPTCPRWQEERRVATLMAAAPTPLSRRAVKAAVREESREVRSYAAAVKTNLPESDTTDPGLQRPIPAPRRSLLLPASSPISSPPAAPPAEPSEDPRDALITSLLAALREVGNYLPEGHPMRAVFLQAAGVQPGAPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5A0</accession>
    <name>A0A9D4T5A0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5A0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056463"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="11362" checksum="FBA3412B766EE98F" modified="2023-05-03" version="1">MDRIKGKRATQRAFHTRLRNDASQLIQSTQFSAPALRVLHDRLKNCNDGLQLRMLNEQLEEHFTDEQAAEDYLSVSEYEDNAAAMLSLLCYHIEQLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5I7</accession>
    <name>A0A9D4T5I7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAF1-6 MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5I7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044634"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF1-6 MATH" evidence="1">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="255" mass="29399" checksum="B6BD20849CAE3D45" modified="2023-05-03" version="1">MAITPGPFRTASKLGMFITMVFFADIYQLRDSLGDDKNEVFKRLKNICLGGYRFDFDCLFIRDGDGQVQMGFNLFLVSGEWDDYLEWPFAKNITVIVTHLRDHMKDIRLPIRMTWANATRKPPPGEENPHGGGYRGLSWQQVELNGFIVGKALYLTRDDEGQVRMVFSVFLVSGEWDDYVEWPFTKKLTATLTHIKDQEKDIRLPIRMPSLNVTKKPAPGKSNAFGNENENVSWRRVELNGFIVNDTLYVNIDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5L2</accession>
    <name>A0A9D4T5L2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_012739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5L2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051255"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="310" mass="33507" checksum="0D357852B4AD1D8A" modified="2023-05-03" version="1">MWLEALGCGSSGSTLARRVCSLHFDERAFTRVGSETQRGMKRRRLCPDAVPKGSASAAGVGRAITEERTGTDAAMLVCPMEASWTVEHNPSALTNTSDNSIHFVESDFAIGCNAEVGTDTGACGDMSLTHLTAGCKVQLGENSEVRSSNAMEKFGLKKGLGELKDQNVTICSLTTDRHVGIKKYMRTCEPGIEHTYDAWHVGKGVKKKLTVAAKKSACAALKDWIQPVVNHLYWCVAVSEGDGDLLVAMWKSMLNHVINMHAGHDSPYPRCLHGDVQNGKWLTPALSRLTPIGRHTPSARGNHYASITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7T3</accession>
    <name>A0A9D4T7T3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADPH oxidase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_017714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7T3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047937"/>
    <dbReference type="OMA" id="FSWASEI"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000056">
        <property type="entry name" value="NADPH oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000258">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000012">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF58">
        <property type="entry name" value="NADPH OXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="466"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7976663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="97205" checksum="46625046896C4349" modified="2023-05-03" version="1">MDIIARLPEAESPTGLTFENLDHLERVFREAVGPGKELNREQFRQIVQSRNAFFAERMFQLFDTDKSGTISLDEFISAVKRFAKKSQDDKLAILFQLYDVDGDGLIQPQELRDVMRACMEENGLQFTEYELDELTNVLFEDADRDETGSVTLDELRCQLQSRPGLYENLTVSVERWLLPPSGRRSAKPAFTSRWPKKLTRIYLRNNAVSAAFCFCFFALQLAVFLSRMEAESMKHRDLKESIDRYWFQVLTWQMGALAGLNHTSEGFFSAQDGAEVEWMPNAPTMGLHSEYELVAREFGQLLNFVCAFTALPVLRHCITWLRSHGAGRFVPLDSSIYYHKLTGWCIFVYSILHTLAHVFNFIRLSKGDCHVLVLFLFTTHHDIGWVGGTASITGWVLLVVLTVMVVCSLPCLRRSGRFEVFYFTHLLYTVFWFFLILHAPNFWKWFLVPGLLLTMEMLVRACRFFSSYGMTTVLKGVILPSRVIHLVLKKPPDFDYHPGDYIYLNIPCLARFEWHPFTISSAPEKDDVIWLHIRSFGGWTNHLYQYFDNFRREASELPPSGRVSATDLRLRSLDGLERAHLDKSRLRDSESVVLMPRGTQPRDSCAFLETGHELEAIVERGLETGARYADYTSLIIAKNPLTVRIDGPYGSPSSHIFRAQHAVLVAAGIGVTPFASILQSIMYRYYQARSTCPQCSHCWVEKLPSSVMKLRKVDFIWINRSQQSLEWFVRLLSDLEAEQALLGDVLERFLDVHIYITSALSRTDMKAVGLQLALDLLHEKDKRCLITGLKSRTQPGRPDWEKVFENIKEQKKGKVTVFYCGPPALSQILHDHCNRHHFAFRKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T803</accession>
    <name>A0A9D4T803_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P2X purinoreceptor 7 intracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T803"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031380"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="17975" checksum="4916333A1136BD69" modified="2023-05-03" version="1">MDPYRDTPRRIPATAVRDDAPSPDSPPSPGEGDDVRWCFCGHCLPSTNAEENVCCRVVPEVVAKGNDDCITRHADFSSVCLNAAVLEAMFYILADFDVQMDAELHKKYRFVAYRLFTKWLWKRLGRHNRVVPPACVVARIRHEYPSATYVGFQHPHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8J4</accession>
    <name>A0A9D4T8J4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8J4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033553"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="16105" checksum="C21B9BC4973508B2" modified="2023-05-03" version="1">MTLGKEERSTVDSSQTGPYVPPEMKMDVYGLDRAALMRQVLLKSRGQSRTPLEELAPLKPGTLHSEEAQARMMNLAEYVRQRKRKSNLQTKAEREAQRNLQSVQLSPYEEHLSSATPDPLVEPEDTYDEDEHCNVSFLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9H2</accession>
    <name>A0A9D4T9H2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9H2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="12437" checksum="8AAB056A3B50AD37" modified="2023-05-03" version="1">MKCRVLSAASIRTSPACQAEQLAIALALLRSDRVDIYTNSTTALRAFSTGAVCENVARALDANGDELAQARARGLGGCAGHWGAGVPDGTGNRGAPLLHTKDAQERRRRRGADGGTFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAA5</accession>
    <name>A0A9D4TAA5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAA5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043403"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="441" mass="48772" checksum="F4F0ADA9FBE62408" modified="2023-05-03" version="1">MEVVVEGQTITEEEYLSGSWTTLEAQRWCARQQPRADTDRKQTGSATADSEHRERGRPRFRARPPQLPTRKPLPKLPPADYKVIIRPQTAASLLHHGATKLFKAVCAAAQVNPTEVVAEDQLRLHPTNNTALISTPSLDRASRYIKLQVVKIGQQEIQVFAYAPAPENSTKGILYHACSDEDDAAILNELRARNKGIDIVGARRLGKSRHIVTIFAGADRPPYVRYWGATYVVYPFRDRIEACYNCRKVGHRTDVCPQQRQVRCKRCGDETHATPEWGTKPTCLARCIVCKGGHPTGGRNCKFKYYSQVQQHNNSKNSTGTKGTTVVIGQQQGGDQENTTRITSDYPAELAEHGLQGRGTRHSTDGGVASPSRKTQLCCSRLHQAPESTRPAEEGLQHIGHYTSHGHGTSQGQGTTRSDPGGEVSEMVRGLVAEVKELKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC52</accession>
    <name>A0A9D4TC52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033937"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="252" mass="28409" checksum="13FAEACE0F836897" modified="2023-05-03" version="1">MEAFLVMVRSYPSLYDKSNVDFKDKELRANRWPIIGQQFPMTGEQATVKFKDFRDCWLKIPVEKRRARKSAVPDKGGKVKSEYSAQYTQSVFASGRCFVSVWAAMTREGFGPLVLIDGNLSASTYSLIIERELLPYVLNGPFKDGCFVYQHDRSPIHTARSVKSLLEGLAVRTLEWPAVGADLNPIENVWGLVKRRLAARNLGSSTKETLFAAIQEEWEALRARPEIVAALYNSMPSRVAQVIAADGRLIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC79</accession>
    <name>A0A9D4TC79_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC79"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025884"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000237">
        <property type="entry name" value="Synaptotagmin 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF377">
        <property type="entry name" value="SYNAPTOTAGMIN-15-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="204"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="485" mass="55005" checksum="BCDC30461C040857" modified="2023-05-03" version="1">MRWPARAWSRHFKLGPEGVYVWIITAGIVTGALLLGLVVWLVVFRLRRSKRNSDSAEPPLLTREPWHRKSTYHYEMVFLDAAPLAPDATQGSDHVRVEVALEIPDGFRIRVWLSQPLAGVLPTKSCGLDLGPAPSLLTPESFDVQPSQLTVTEPVQPVARPGFVRWNSFCSPSAEGLVGNLMPKGCNVGYSWSDDEDATVPRCTNGRLWFSLNYKSESEELNVNIIKAKYLPGRGLTNTPRDPFVRAYLLPDEDTFQQSTVKTRTLAPKFNETLTFKISEDEVRARSLRLSVYDIDRKKVRHCLGHVTLQLEKEPLAPDKVIWMDLDNVPKKSSQIGEIQICMTCNPFTNRIRASILKVRKFSKQEDASKWVYVKLSLNHGRKCVKEKRSENREWGNGDEANFGDAFTFGVAGRYFDSCSLSFTVMVSPDGADFRRLGKTVLGPFMYARGEELRHWQDMLTNPRSAVTRWHALECPTGRDEWKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YN33</accession>
    <name>A0A9D4YN33_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_010534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YN33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026481"/>
    <dbReference type="OMA" id="NINSIRM"/>
    <dbReference type="OrthoDB" id="6495498at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7983262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="216" mass="23852" checksum="7D1EFD7BB33230D9" modified="2023-05-03" version="1">MSSSLPFSSRGPETRGARHSLSSDTDSSGSSAIDDEPAFVNSSVDSEDDVAARSNGDRAPSPRIPEEVSDEPTRDSLPLDAATGYRSRAGSSGPMCRICHESDQKDKLESPCSCSGTIGFVHASCLEHWLTERNVNFCELCGHRFQVVTQPLTALRFFRWVSQSKGWLSRECLCDLFGLSIVILFAVCVFYVLARWVLKSDRVAWCVVFLYLINIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQZ1</accession>
    <name>A0A9D4YQZ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_023880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054607"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7984761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42348" checksum="67D978F8ED570E1A" modified="2023-05-03" version="1">MHAFILAGSQLLRQVRTRKHLLLRFFSSKNGGVLSNSSTIRRVCVPPVKPLASVVLCRTCSSARRVDSGELRRLLRQARPERFRLGAAVLLLFVSSSVMIAFPFCIGKVIDVIYTSSDNEELRANLNWICKVLTGVVVVGGLANFGRVYLMNTSAQRIINSLRKQAHASLMQQEVAFFDRNRTGDLITRLSSDTALVGMSLTQNISDGLRSAVAVFGGVGMMLYTSPQLSLVGLSVVPPVAVISFAFARRLRQVAADVQTRLAESSAIAEEQLSHIRTVRAFTKERFEMNRYAAGLSSLLDKVNTETRLRAVFFGCTGATGNMIVLAVLYYGGILMSDGRLTLMSVFPLVALEASSLKQPKHWVLQKRYGKLLIVFQPYQIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P999</accession>
    <name>A0A9D4P999_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001600">
        <property type="protein sequence ID" value="KAH7932339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P999"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048763"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7932339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="82" mass="9575" checksum="1DE9613A69611C39" modified="2023-05-03" version="1">MATPTVPAAQPATPLNPFVVELPEKLDFRRPEEWKRWFTRWERYRVISGLKKQDDETQVNTLIYAMVREAEDILASLKLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCB6</accession>
    <name>A0A9D4PCB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein hook</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_005712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with microtubules via its N-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hook family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056535"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF39">
        <property type="entry name" value="PROTEIN HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="99"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="490"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7935287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="692" mass="79730" checksum="28E2BCBFE27C0651" modified="2023-05-03" version="1">MNSITDSLISWLQTFNVSAPHKTVDQLSDGVALAQVLHKIDPDFFDSSWLSKVKTDVGSNWRLKFSNLKKILKAIIDYYNELITKESPSSYTGDNFDLNEQLKKALDELHATAQAKEQITQRCHELDMQVTMLQDEKVSLMQENEKLMEKLNHVENLEDPSTPAGRRYQQSQQRIDALQAEVFKLETAKDELRIKVEFQEKEILNLQEKNEELHKTLNEAQTLKDELDVLRHTSDKVEHYEAAIETYKKKLEDMSDLKRQLKLLEEKNTSYMQTNIELEEDVKKMAAFKSQADLYKKQTQELRLQLADETRKANRAEFEAKKLHEKLASLQTEKESGAKAVGAISDSDMLETVPPEIKEKLIRLQHENKMLKLERSSSEGQQVTLLKTMLEDAQSRQNDLETEVSWCRHRAAEAEGKPQLPHTYNLPIKVVEALRPVYQRLSDPQLQARCRGNKTQNAAESLHSVIWSLISKQQHASHFTVDVAVHEAVARLLSQRNLELESQLEDSREAASAHEGAEARQQLALAQRRCKELEGQLREREASLEAMATRLAESCESQSELTEQLEKKAEETRVMEERYQKYLEKAKNVIRTLDTRSPSSAEVVALRNQLQDKAKHISQLQQELEMFKAQWEKEERLISTAFYNFGAKSQQRSAEERIVHLTGGQSFLARQRQATSKRHNVPGVQTRTRTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCF0</accession>
    <name>A0A9D4PCF0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCF0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049234"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000243">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF21">
        <property type="entry name" value="KANK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="4" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="5" id="KW-1053">Target membrane</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="855" mass="93382" checksum="46ED0E1CA770B9D4" modified="2023-05-03" version="1">MYLLLATGILLTALVVWLLVLSGRLAAMLDLWPLLEEHRALYSQFPGLRAALAAQRHHLTGTSRSVAGHREQAATSPIGSSNPLGVNRAALANVRDLMATSLGRIRHLEDEVKAIPLLQEKLSLLEEEKRLLMLQLKTKSNQLGQRSVGVGDNHILGPTKKDSGGDALDEYIRKLEKQGITASPKTSFSDAKVQATVPTTSTHSMTVSTKEDASFPESPPLRPSRSLDRAKLATVQIQRAKKQFESKETATDLEAGKDVHKKLEQLTFDVCEPTSIKPEPRPCPHCEEQPSAATEVTKSRSTDAAGLERNVGVQFSPGPIRKRDVMLQADVTERRHVGLQVTTVEAKPLTVSTGTGITDVRRVVCDRCANLRQRSVAVGNHVSRRDMAVSISLQAERVSQGSGDCSVTDVLCEKCQLKQTETIGVGDFDVNCVVCDACMEKSTSEEKPPSTQSVSTAMTSSVEEPRSPGAVRGVRLCDKCSCQITSVAKDFIDKNVLDPVLPTLSSRIPKLSGRTPRKTVAPRASSVPPSSENRNALLGSLGDQKMAAMSQQQLREPPARMAERSEKHEPSKEVKAACKVLNDYLMKPERGDPNKLKTAVSLIQQEWFQISSPADADPNMVEDYMDTFEEFSRHLLHRIVNMADVNGNTAIHYAVSHGNFDVVSILLDSKVCDVSKQNKVWYTCIMLVSLAEIKNDTHRLVVQRLFQLGDVNAKAMQNGQTALMLAASHGRLEMIKLLLDAGAEPNVQDNDGSTALMCAAEHGYIEIVRVLLAHPDTEVCLADNDGSTALTIAMEAGHKDTALLIYANSNFSRGSSPHPFWICEFRFVLIFENAQTPFSKVNASSQPPTQDTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCN9</accession>
    <name>A0A9D4PCN9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCN9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032803"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040736"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33601" checksum="549AF8A2B5DB43F6" modified="2023-05-03" version="1">MYAYVRFVEEMGNSSLYTIPAKDILNFQPKDVNDFDNRTTYTAHWHDEANEENSGEYVIQILKLAASKKEMQQQLALKRPQIPKLNPSDVECEEEEQTQTKTKTARRIPTQDNGPVEGDLPRDQKLPREGSRKPAAAPGKKKSSNWKHTESSSDSDDSVVPASKLKSAKQEARFWRSQCMAERKLTASLKEEINFLRSKIVDQLTQYSESVEPAAPPPFSETSDGRFHLCNEVYTTSVQAAKLFSNKKPTILAREAAQLIWGIEVLAQRSVNGRVAPTKQGEASAQGNKNEPSEYCSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDF3</accession>
    <name>A0A9D4PDF3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20761" checksum="243CC1642D60FFF4" modified="2023-05-03" version="1">MTPTQLDKIECINKTYIVVATGLPKYAKVEDLYGTGLLLSMSDYVEPALQDQNERIQLTSAGIAIRRELGLYNKHLPQILPTIPPWEDITVTDNQPLPKHMSQASDKQRRDYYAQRHIEYLKTISDEEEIYTDASCTLEGFNTWTILNLRTGEASSFSMTHSCLLPEAAEGHAISEALAHNHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEM5</accession>
    <name>A0A9D4PEM5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030859"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="269"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="404" mass="45855" checksum="EFA8CAA279F34FB2" modified="2023-05-03" version="1">MLAGQRTLPEPTQPAPPSTAEECYLRCLDDDRCRGYSVNHVRQVCALTWFDVVNKSDYLLADPNWSFHRKICLPERPCLRHWSFERVPQFHLVGFEDKVVSAVSDQDGCLQMCASETGFVCRSTRYEPARQRCVLSRHDRRTAAESFRRTAPEDGNAADVLYSENQCVSEPPRCNFRPLRGRSLSRGHVFVDEEATSHSLCQEACVNHTDFVCRSFVYDQSRRLCLLSPDDSYSGGAAGPHPEDRAASDGEEDTTLLFEKGSCIDVEMRCEATAMTAIIQVTSSFRGRVYAVGHPHQCFSSSVTDTGHVALTVPLHGRQCGTKNLGNGTFLNSIVVQHHPYVLQSSDRRIDISCDYEEVERKLRGGKQVLEWVRCCLSYLFHPQHYRENMYQQAPSKIIEEPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEX9</accession>
    <name>A0A9D4PEX9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEX9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052110"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24237" checksum="49EF049C9B388552" modified="2023-05-03" version="1">MGGEPVQILRVKDGHSVEFNEAKLERILLADHVKDRPVVVISVAGAYRQGKSFLLCFLLRFLRNIGRSNWMDDADTPLRGFLWRPGSSRETMGILLWSEVFLMKNSEGEEVAVLLMDTQGTFDGDATTKESATIFALSMMTSSVQIYNLMNNIKEDDLQHLQFFAESLIASRLEIKEGQAAELKTLRQSLSSSFCEIDGFLLPFPGTKYTSFLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFH6</accession>
    <name>A0A9D4PFH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036524"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="330" mass="36287" checksum="322CA8BCA83AE608" modified="2023-05-03" version="1">MARFARLEERVVAIDTRVAAIESHLSALDTRVAALEARQSTTQATLAHLSLPAPLTPAPTPTPHVELSGVLRQAEHPAAPPPEYPPDTIPSVLALQEPLAPVKLRDHTSCHPPSEAHPNVATLVHRNLTAVLHQLNSPPKAASAPLLLVLRKALSCAGRNALIADRDRFRSIRLTNSSSSALTGLSAWTETPLADVRSATSTIPAAPHSSTADSRLLHLWEAYHAVHRRWQTQKHNRRLRLRLARLASEMEEHCSLLRQHCWLDLSQGASYTTTVPVCACVLLQLFFLSAAFCCARPRRNLSSGHFQRARWEIERLPPSERISNQSGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFP6</accession>
    <name>A0A9D4PFP6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFP6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038868114" evidence="2">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7940046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="16324" checksum="8EE7A16E7CFCB7ED" modified="2023-05-03" version="1">MAGASFETQTFAAAVCALLVCSVFADKKDEKVEARGGLLGAGLGGYGAGVGGPGLVGAGLGGAGLGGYGGGFQSGYGSSAGGHQGGFQGGASGYNQGSGAFAGGASNRNVNAYNDNKGYSHSSGFSSSDSNSYGAGNKQGSSGFQGGAAGHQGGYGAQSFGHNAGTGYGGGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFV3</accession>
    <name>A0A9D4PFV3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042425"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7938929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47684" checksum="9E91472D6DCFF1F7" modified="2023-05-03" version="1">MLLRSGTVTAREGESPTDLKSNIMPDKGKQDASAPDTPRIVEQLTALLERQATPADTFRLPLAVPTYEGHTDKKSVADFLQDLKDYRDAQALPNETLLLRVLPVALSGSAARWRRRQSFESWSHFEQLFRAEFLPPDYAVRMKDELRSRTQAEEESLQEYIRSLQELYDRADPSAPEVERVIRAIKQSHPRFQAYLRGRSFPSLDVLATAAGDIQAAMLAELTYQPPPPPESTLEPSCAWHGRSNPMASPMTPPRALDPFSHHNLPAPSAFPSTTQERGTPIPGASTQGQPVAVQVGTLRYASSVEVGATIGASVQADHVLAAGETIGAGDGERMPIAGQHSTAPRGHLTLRRSWWNYCGSSVVYDSSSRAASRAAEAWPPGVLVFTSSSRQESQPRQTFDKATHAQRDKAASLPARTTAREPSNQRSCEVLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFW9</accession>
    <name>A0A9D4PFW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFW9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17881" checksum="F8ECF23A3D3978AA" modified="2023-05-03" version="1">MAKASHRDSLILLGDFNAAHTEWGYLKDAAKERRLIHATEQHNLTLMKLPNSPTRIGNSVERDTTPDLAFTNADRHTTWQRLEETLGSDHHIISIAICTGKMRRPLGKARITEWNKFRERQQDWSLDNCAPTNATEWEEAIKCRLCDLVSQYVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG87</accession>
    <name>A0A9D4PG87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031680"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7940316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="328" mass="37827" checksum="F6F3786701AE9E81" modified="2023-05-03" version="1">MSNSDEDASKSASSREIRHLTHSVEDSIVSKVNELSSALLDTSTNIHCLNSKIQAYRQEQNAAVEVLKENVDVCLRHISSREATTPLQLTSARDSPTNPWRMVRDKETTILELERKNDHLRAKLESAQEKLKEKSDELLTSSRLLSEKSQEALLLQDSLVIAERRLAESQREVERAALRLRHVEESLQGLQQELKQVHLESSSWQERYMREKQKTSQLSEEIAQSRIQRQRFQKPDGARSEDDTDNLEKGNNLVNGSAQDFSGIASPEEFNRLILEKRDIEEVCLSFDRKFQKQTQVLKRLDQMLKESEGKVEKLTQVKLEKQKSYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH30</accession>
    <name>A0A9D4PH30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_002032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7942855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32121" checksum="2E10970DBA813E52" modified="2023-05-03" version="1">MSGTDSGIETGSESNGSTSMSVGSPPSLNMDNDHAEPQDEEVGDAVAPFFRSVQPLAVQCLGAMATESSASLLGHDGGMEDRQPYSSHFWHGKMRMQQRRARRWRNLSANCATFRNIIGERKLRIAAITNQIPLVRRLLETGVNPCAADERSRTALHFAACKGHLEIIKMLLEHGANPNQRDIVGNTPLHLAVCTSHTEVITHLLKAGTDVNSLDNSGRTPLHLAQSKLRVLKVDVAKSSENVKQEVMNVIEMLQVYLQRSGKPAESDLLGAFSTRLRLHQTRQEASCFYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHB8</accession>
    <name>A0A9D4PHB8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="70" mass="7456" checksum="DA8CA9F3064D7E77" modified="2023-05-03" version="1">MTGGALDIPEQETGVQRQHCTSDSLGDVVSALEHARNRKPTAVQVRLDVQSAFGGLPHLVVKRLPVVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIJ8</accession>
    <name>A0A9D4PIJ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIJ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042497"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="21473" checksum="CC995001E7DE1A32" modified="2023-05-03" version="1">MFGYLVRFLSCLMTPTDRSVGQVRLLVEQLCKPSQLWSLGLLLALLLVLCGSHGASGFLTGRSSNGAGSGGALVASSFLRSLWKRASMRASMRNSMRDSPIYYVSTFVRNKTPAQQQAAVLSPLFKIPIEFMSNARPLDVVKGIRKPSYSKPYRKQSLYQTSKMILMPIKFLANGKPRRRVVIKTPPHYFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJB8</accession>
    <name>A0A9D4PJB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_015336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040104"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000271">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000372">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7944085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60682" checksum="04EABC41A58ABE73" modified="2023-05-03" version="1">MLLSRTKPAVSGSSSGNADGDGLKPERQREQKSAESRLPTLEEFLEKRDFTGAMALLEFTGTSSSSSQSSRLEAALWTAYCAFHLGQHRQAMRIYQDLMADKSMPPPLDVWSYLACCQFHLGLYKEAEASVLKGPKNQLQSRLLFHLAHKAGDEKRLMALHQSLQDILEDQLSLASIHYLRAHYQEAIDIYKRILLENRDFLALNVYVALCYYKLDYYDVSQEVLAVYLQNFPDSATAINLKACNHFRLYNGKAAEAELKSLRERASPTFTYAQDLIKHNLVVFRGGEGALQVLPGLVGAIPEARLNLVIYYLKQDNIKEAHNLIKDLEPTVPHEYILKGVVNAAIGQAQGSREHLKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLLYLNSIKSYFYNDDTFNFNYAQAKAATRNFKEAEEVFLMIQSEKIKSSYIYQSWLTRCYIMNGKPQQAWELYQSMDTSSESFSLLQLLANDCYKMGHFLYAARGFDLLEKIDANPEYWEGKRGACVGTFQRVIAGKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLY1</accession>
    <name>A0A9D4PLY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_007570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the GOSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055597"/>
    <dbReference type="OMA" id="LKYDSRH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7947124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24636" checksum="98EFB9C4448D1322" modified="2023-05-03" version="1">MERLYHASNSIVEDIHQCFKRYEVSVGEEAQRIEGVIQEKINELSANCERLGILANKEPVSRRQHAKMRVDELRYEQKHLQAALGNLQRRRFEREEALQCREELLSKKFSTNDARDTAINIDESLQFHSRAQSANKNVDDLIGSGTSILSNLREQRTTLKGAHRKILDVANTLGMSNTVMRMIERRTYQDKFILFGGMFVTCVVMFLVVKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMD4</accession>
    <name>A0A9D4PMD4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_023069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMD4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039507"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057780"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="859" mass="93308" checksum="48D0008189840C47" modified="2023-05-03" version="1">MALGALLTKGHASVALDSAKKQLHYIVDTMPGVLQKPINDMGLIVGPDFKKFSAALDERLKDCSAEARTVMDDVFKNDPLLKFVSTAAERTPGVPLRPIVDFTRSTLYRLSGYLHQVLSSLAGKTSTHVENSSTFEDEGRHAERRRHCGLVRRHVTFHEFSVDSAVATCEVALKADSDLPDRGPFDVPELSELLRFCLSNTYFSYDGIIYQQTHDLLAVKEMLDKINGALESDDLTKVPDGVNQALTSLGSAKSACVPPSCPQDVKDKLGNVETELNQLLGSTKVDVSPQFVQLTNKLKTAKGLGKVPSSNIFEKNLDNSTKGVIKALEEFDGRLNKSIDQLEDSLKDAVKSVRKAAASVDNPPEEVSSVLGTYALLVTAVVGVISIIVGIYIFGNQCIVSRAPTGCCTFNIASWAMVVAALVFFLSFPIFMVASTFGSSAGLSIDRKVCAPALDLGAPSSRSFIEFLAAKLGNQNKTSHRSAALHEGDVEMTHVARVATGRRRKGASSSELRRLVATSPKHHRDPAKRHRVPARGSRSHETARRFEALEHGVVTRRRRGQKPRGADHGADDVGGFEPPADIASALGKELTPTALEGVVDRFAQCSQTGLSYFKLLGKELVTSMARAYLGQKSPWLGLFDDSAGTPKLDALENLSTKFPSVGDDLKNTLTDVSPATTIDVNEFETISTKAKSAKEDFGKFGDMRTELQGYVNNAGPTYIADNLPKWDSMKSGSGDSAKKVLQMGEKAKAAFKSDLSLFFDHVKEQASRSCHYGGRHHQFVREHIGDCRPLYVLYLTTVETACNQGVSLLATFWCSVWWFLMLGIKAVVVALMLSTYFARAGVQKEGTTDETAKGDTSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNQ7</accession>
    <name>A0A9D4PNQ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNQ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032836"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="293" mass="32017" checksum="C5CE8FE708303ED0" modified="2023-05-03" version="1">MQGTSRPSHYHVLWDDNQFSADELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSSNGDDRTVVALARAVTIHPETLKAVNQYVLLLVECSYQVWVARCAAVFDGRRPGLPEVLAKVRKEIWFVLHRERQRLGVKKFLETWHRPAVIITRAGLGACDIRCYTAVMTVEVSAVAYPCFACARVIQSPCWAPPTRSMSVGSVLCSATLFAATDGGPLVRVGHRWPSAMRYSLGTSSLGAATKVAAPNGSPNAVAVQCPTIGLVEPNCAPPPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPN1</accession>
    <name>A0A9D4PPN1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040225"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7948008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="67" mass="7232" checksum="7C2BF85D81DCA468" modified="2023-05-03" version="1">MAEAVLANVKANRWSAQNVLLASDGTLMREPRGPAQRFAFQCSAAIVRGQEVILCGTCFIEHVNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQF1</accession>
    <name>A0A9D4PQF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057979"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="18597" checksum="48B3674E5294F4F2" modified="2023-05-03" version="1">MAEAVALCDETAENVNGEQHMAVDQEIAKEDAEGSEDGEGECNEGSIEEIVEEMDEKRDEQADKPVRESQRGGIETGDSRNGEAAALEKGKYEKAGGDEGAGTGKEENVKKDGGEEEEGQGKNEAWSKKDESEDEDEEAAYAEAAPMAAANGAEGEGLPEAIPYWLITSPPITSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSZ3</accession>
    <name>A0A9D4PSZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037177"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7952443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="26400" checksum="EBC62C5622DC2554" modified="2023-05-03" version="1">MLIGTTSEEGALFIDIIRNAAPDLDSVLTEDYRRGVALALYLVFEIPVDKANVIVEHYFGAPEVQHEQESVIKILGTLLADVLFNCPAHFFASTAAKEGVATYVYKFDHRPSYSMWPKHYGPTHVEELPFTFGTLPFFSDESRLTSPPLTEETKQFLKSIRFTPEEQSLMLQTVGVWSSFIKKGKMLLPGSNETWPKYSAEHPEYVTMKPNCFKRTKLSEPCHLFKPFLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTN8</accession>
    <name>A0A9D4PTN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_000902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026607"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038586476" description="Secreted protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7955452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14341" checksum="12B1183BF09E491D" modified="2023-05-03" version="1">MWSLLWLVALTLACLKDAFELYMFHFAYYIVNPSQPGTQHQLQQPVVLDTIVGEGQKASGTILECLYLALLQDYLHYYLPHDRDYAPELPGYHPHHQVPSFGGSMPPRQVQTIHLAACACITLRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU52</accession>
    <name>A0A9D4PU52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_023465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038518"/>
    <dbReference type="OMA" id="MTIESHM"/>
    <dbReference type="OrthoDB" id="6514353at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039743345" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="11">
        <location>
            <begin position="93"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7952444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="620" mass="69669" checksum="85862B6326581725" modified="2023-05-03" version="1">MYSRIIVLLLYGYALRSAHARCYIFQPGDPIQDTDEKIYLPQPFNVTSPLEAGAPTTAQPASTGKDQLSLVVPPDDMQPVSTTTSQPISTEESPIVETNSGPVQGQRVYAANKTLYQFVGIPFAEPPVGPLRFRNPVPVKPWSSVYQATKKPFPCLQTDFYINSNVTIPTANSTEDCLYLNVWTPSRECVLGKFSCVPKTVIVYIYGGTFSFGSSGWDWYDGKEFVARGDVVMVSMNYRVGPMGFFHSGTAHSSGNAGLHDQLLAMKWVKQNIRNFGGDPDDVTLVGQSAGAISIGLHLVSPLSKGLFKRIIMESGSPYFRIADNTREGPHKVEKLARALQCARNDMTIESHMAEMVECLRKIDGKELLIMSNTIFGVHALTFFPVFGDDIIPDDPYLMMEQKKFHKADLLIGNNLDEGSYFVFYLFGRALDLEQAHKITKYEVDLYVSYCLQMLLRKNVSPIRHYYLSHIGERENIKALQKAAEAVGDFAIICPTKYFAESFASMNNKVHYYYFTHRPSFSSWPGWVGPTHGDEVFFVMGLPFSSPTIATDQERELSKLMIEAWTTFAKTGKVPDVASKPWPEFTAKNQVYMELNPKRYTYGRGPNEKSCNFWKSYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUC4</accession>
    <name>A0A9D4PUC4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HPB52_015408</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
            <tissue evidence="20">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUC4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033751"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040679"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000004">
        <property type="entry name" value="Meis2 homeobox isoform 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000063">
        <property type="entry name" value="SEH1 like nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 16" id="KW-0371">Homeobox</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="19">
        <location>
            <begin position="635"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="16">
        <location>
            <begin position="637"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="310"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="734"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7951920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="799" mass="85968" checksum="1BC1EC9157522665" modified="2023-05-03" version="1">MFVARSIAADHNDLIHDVAYDFYGRRLATCSSDQTVKVWDLGEDGEWRCTANWKTHSGSVWKVTWAHPEFGQVLATCSYDRMATVWEELVAGKSGVLGGSGTGSGGERSQSHWVKRTSLVDSRTSVTDVKFAPKQLGLQLATCSADGMVRVYEAPDVMNLSQWSLQSDINCRMPLSCLSWNHSFNRNHPPMLAVGSDDPGPSNTGKVHVYEYCEGSRRWTRVETVVTVVDPVHDLAFAPSVGRSYYLLGIASRDVRIISFKPLLSEMTSPMQDGVTAKFETKVVAQFDDHNSQLAAKEAKVSCRGVMQEASSRGDTAVSMPSLQQPLGGSGHCSDRDSVPSRESSPVPAAPTSPSPSPLTPTDTQTQAQLEADKRAVYKHPLFPLLALLFEKCERATQSAEAPCSESFSSDIQAFVQHQEQDRKPFFSDDPEVDGLMVKAIQVLRIHLLELEKVQELCKDFCNRYIACLKSKMQSENLLRSADFPGSGSQCEGGGSMSDTASSSSCSSPPPPVASNPSPPPAHSLVTATQGNCLSSSALSSGQVVSGGTVFQVVQTTAGFVAQPIQVGDAKQGPSLFQIQTSATLPVIASIHGGTPLSQIGANLSSSNQDHRVSNLGPRALSLSGDDEDEDILGSKKKQKRGVLPKQATSIMRSWLFQHIVHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPENSQQKAKKAKVQTVRPVERFWPDAIAALQPRPSSHNGMASVSSPSAHGKPSTSGTSLCSEASDDSACGGDTGHSAAEDESRDHGTGGGSSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV27</accession>
    <name>A0A9D4PV27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029050"/>
    <dbReference type="OMA" id="CMEATIR"/>
    <dbReference type="OrthoDB" id="6487831at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7955622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="331" mass="38330" checksum="6F4C61543AE3EE4E" modified="2023-05-03" version="1">MSKRTSTTRPKPYYQIIDGVPRCPFMTPESLRQGLDFVARKGDLLQVSYPRSGTHWVQYITQLILKEGEPVDTYEQFMEGAKFIEYFSGIDNNCKQDTPVRTLCTHLPLHKDKLNPEAKYIYVARNPWDVCVSLYHHERNISVFRFEDGTFDDFLEVFLTGELGYGFYFDHVTAGYALKDEPNVFFVTYEELTRDTRGTVIRLARFIGERYGKSLEEGGEAGEGRLNEILKRSSARSMKDVMVFNLRENPDPGLQKRLEELNVSSKASHEGDVKRHEVLRKAKIGGWKEHFSPEQLRCMEATIRERTRGSGVMDLWKDIRQETLKLCEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVP5</accession>
    <name>A0A9D4PVP5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVP5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031107"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="135"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35154" checksum="E267258AF37915D8" modified="2023-05-03" version="1">MAGIRDHVLIECGFIVDEHSNETASVCMGQGKWVIMPHDGDDLALAIVLVGATGFGMSTPASENDSSSTASTNGCATDIYAVEQCAEIYDIAIAPTASAIAALLDFLEQAFLDSAALHLGPTGHEGDVRERIQFLDVGCGSGSFTKKHLLPRLPAWCERLVAVDNSDAMLKFAAESSADPRIEYRKLDILAYEDVAQFVNAEGRFQRVYSFLAFHWIAEHRIALKNIGTLLAPGGECFIVFSDKLHVFDVFAAMMESPRWKKYSDILLQMLPETRLLEDIYSLRSYLVNLLQETNLLPLACEIFPLKEKVGLSEETAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVX9</accession>
    <name>A0A9D4PVX9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_000471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVX9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037233"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044050"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="559"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7955353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="750" mass="82223" checksum="25E959D997CA36BA" modified="2023-05-03" version="1">MIARDLQPYEFVENKGFQDLIRHLQPQYKIPHRTTFSRTVIPELYRHTVDSLKTQIASDIAKGLESLGHTTGIWNGSHFSAWDSLQLAIKDAKEETPVFSSLCKKARALVGHYKHSAQATRRLKDSQKRMELPCIGLIQDVDTRWNSEHAMLSRLVQLRDAVSLEIATSETSLSTAMEYIVEGQDVSPEELSDESWQSPGLRAQEQRRAALRLATAAAKPTTTPASLPSSKRVNASPPQHRRRAPLPRLPADTIHIVGRPKSPVELTKLQPWHLYTALLQAACLQDLPPASRDTVRIHPVNNTFTLSVADSARAQAYLRITSLTVSGNTFTVHLYAPPPDDALRGILYHAFDDFTDQAILEDLQASNPTLSVVGGRRMGKAPHILVTLMEPKLPRWIFYHGVQLRLLPFRNKVEACYNCRSTGHRTDVCPKPRQERCHRCGAAHPTPPEGSPPTCNPRCIVCNGNHSTYSSNCKHRYVQRPQRQKAPVPDTHPSPQQPVPPAAAVRSSQQAASGPSPAPPPKSVTASPPPVPAVPKPASQPMNSTWPRGAPGLPSEPQVVALQQENASLRQQVTAQSAQIAAQKTQIDSLQAKLQALEEKLESAITVKSSLPSTICSSSDMDVQTPEGCTGKRRRPNTPLESLHLSEEVQVSIKTALVDLEKRLDSRFNSVHQLLTAQHEALNSLRTDFAAYPPATSFQSLQSTVDSLQTAMLGSIRAKPPLHARTTTSSGAARTSQTPAEATSSAVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWM6</accession>
    <name>A0A9D4PWM6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWM6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034568"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="571" mass="62218" checksum="F5B651DA23114799" modified="2023-05-03" version="1">MDSPLDESGVDQSALEVSTLTGTAREDEQDDSNTITLIVIAFCGLALILAIVVAILFTRDLEIYDDSDDAGGRANDDDTKFPRGSRSSSDSGSGPPAAVTDTPTTMEAPAATTPGRVPPTPGQVPPMPPSVSATKPTTPAHLTTTTTKRATTTPAAPSPPSRPPPPPPPPPPPPPLPPPPPPPPPPPPPPPPPRKQSSIKPQSLLCTFGNKTNYGTKFPADGLCDYIFYDSMYKNNKNPLVANWDYDVYSILSKAQKTDKTKTQFGLGFAFEHRDRLVQDLVNSSLEVFWEHNVFHFGILDCPAHGTKKADMDDVFVALKTLDDSVQKARASGNASYIVLGAVSHTEEWNDYFKDKFASVFTPDLFISVSHQFRGDPERSSCRATPPTILRKPQALSDAHDLYDAARGLASIASQARGPHLSLSVSMKGRWSMLQATSKARIFSACENGIPRPFFGSYAEVCNTPPFSSNIVFELQYYSTRSFDPGTQRMLVYEDEESLRQKLCFAKANYTKVEFGVAVYDLDYEDADNECVNQNFQGAYSRLQTASTVAKYLANEFTDPSKLADCSKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX00</accession>
    <name>A0A9D4PX00_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX00"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055983"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7956702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="578" mass="65295" checksum="581BE94922D43A04" modified="2023-05-03" version="1">MDASSEESGLCGCPEPVLRSLCEDALCNAARRDALSRTLRRLDGRLLEELEVLEQEKHALRRKLESLSGESDSRLAELQADLSQARQQLADQQELLRALEKERGALVHEMADQNQRLAQELKAARRAEDQAAGQYRSLRQQLSMRRSSLDDHVAQLQGLRDEITLLSERKAELERRISALVDERESLSLSLEESGDRILLLEKQRHEYETQIRQQQRDMEELRIANGHLQDRVDALQRQRTSSPLLNGLLNTGQRSLFNEIEMSSSSSADDEAGSMGRRSRQPSQLGSSSAGFPGDFDEIECDDCDLATDEDKHLRQELAQAVQDLQRLASELRRQRESSSTTNSDSGVPPSPQELDPSEVSAHMLHAVVTDLRALLHDMLAGGAAVCQACQAAAERAREEAELRRELADKSDELRRRSADLAEAQRQLALRDTELRALHEERDRLRDDVGSSRMAKDEIVKRAWDTRDQAVARKNNTEIELAKTRIELMHINSQLMEAIQQKVELSQQLEQWQVDMQSLLDERVQKQLRIQEAEDRRRKAKAAAANGASASPQQKTPSKGGKLFGLWKKQQSPQTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXF3</accession>
    <name>A0A9D4PXF3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_019112</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029061"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 16" id="KW-0769">Symport</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7957461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="28532" checksum="2F54695A63051BD7" modified="2023-05-03" version="1">MAETDENSPLAGEPRTSLVNEGGCNAASSDRHEQHSSSAVNSQAMTEVCLTPHSDAPKDATTDSLGRKSGDREVWGKKADFLLSVIGFAVDLSNVWRFPYLCYAYGGGAFLVPYLIMLAVGGIPLFFMELALGQYHRKGAITCWGRLVPLFKGVGYTVVMIAFYVDFYYNVIIAWALYYLVASFTSELPWTNCNNSWNTDHCLELAYGQRLLRLPANESSSPLDDGVEGRDANATDDTDRALAVDLRANYTTPAEEYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYY2</accession>
    <name>A0A9D4PYY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYY2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="155" mass="16524" checksum="3B7F95385F17D8DB" modified="2023-05-03" version="1">METDTVDWCWKNAATVISPVEQLILPDVRDLPVGGGAVAITLCLDPAGHSPAGPAPKGLSRHGLTEETTGADYTRRRPQIDDDGAGQGINSPGVIPRTWHISKVRAETFPWERSARPAPKGSMRTCIRSPPPRSTAALRLVARVCVCAVIPNLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0D8</accession>
    <name>A0A9D4Q0D8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0D8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058205"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="269" mass="30813" checksum="453F00EDD0756D28" modified="2023-05-03" version="1">MVQRKIKGKKGKKKIAAAPLSVKKPEQKKVTNPLFEKRPRNFSIGQDIQPKRDLTRFVKWPKYVRIQRQRAILYQRIKVPPPINQFTQCLDRQTATNLFKLLDKYKPESKAAKKQRLLQRAEQKAKGKEDVPTKRLPVVRQGTNTVTSLVEQKKAQLVVIANDVDPIELVLFLPALCRKMGVPYCIVKNKSRLGRVVRRKTCTCLALAQTNPEDRSNLSKLVEAIKTNFNERYEEIRKHWGGGVMGNKSAARVAKLERARAKELAQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0J3</accession>
    <name>A0A9D4Q0J3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_011575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0J3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031358"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21704" checksum="F417BC3AD9EC7AF7" modified="2023-05-03" version="1">MCAQQAGPNFNRNVSPMFLRGLLGVHPDNRLHRLPALHHTEIPEDLPESFDAREKWPQCTSIGLIRDQSSCGSCWAFGAVEAISDRICIHSRGKVQVNISAQDILTCCASCGRGCLGGFPSSAWQFYRDRGIVTGGLHDTGDGCLPYVFPPCEHHTVGPLPNCSENISPTPRCVHTCRKGYEADYSKDKYKGNAPFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0Q5</accession>
    <name>A0A9D4Q0Q5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0Q5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10526" checksum="AD154687984E954E" modified="2023-05-03" version="1">MTALFMHRINPDMLATCHFCAHEYKKFENMLWLCPVNGLTELKFQEAWNKAITSSKYELKLWAVRRARDVVESLTSSAILGGLQLASSGYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q347</accession>
    <name>A0A9D4Q347_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q347"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055954"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12177" checksum="8CA44A405D2724A2" modified="2023-05-03" version="1">MAGRGRGRGRGGGMSFNVEQLGLTRQEAALTLCAQPPPAFPPLDFSPAPLVNSEENTYLAVLLHEQRKNLLASSFNILPCKPQQTVERYSDRYRVKAPDVIYGNLIFQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4W9</accession>
    <name>A0A9D4Q4W9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4W9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033901"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000002">
        <property type="entry name" value="Cereblon, isoform CRA_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="343" mass="38472" checksum="82597467893BDA91" modified="2023-05-03" version="1">MADDIIHLVPRAEDADEEEDSASASAMDVSYDTSLPAQHTYLGNDMEDLTGRTVFEEDSLQTIPVLTSHDVILVPGQILPLQIFRPLEISMMHRIIENDRTFGIVGESSIASSPQPLGTTAEIRSYKEEVDELSGVATLVVKAEGRQRFRIVSSRTRSDGILMASIKILPDKPTADVGEAARLPSLSRFKGRSTFRYAPSERHKDPYGFSHMTAWPAWVYRQYDANLLVSKIETELREWTENFATLSLPRDPCRFSYWVASSLLLDDKLRLEMLSYDNPVQRLRCELAILRDCRVLTCKECNQKMADRSDVFSMSQSGPQGAYVLLASGIHGGNEIAAFVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4Z1</accession>
    <name>A0A9D4Q4Z1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4Z1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036869"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="39630" checksum="957143929A8E3D19" modified="2023-05-03" version="1">MADRMLLDGYRQAGYEYLIMDDCWSAKSRDAQGNLVADSRRFPRGMKTVVDYVHSRGLKFGINAGIAAKTCNGYPGSLNNFERDAKTFADWGVDFVNVDGCNMDPKKMDELYSQFGRALNATGRPMLYSCEWPMYQAQSGITPDYEKIAKTCNIWRNYAAVTYNWSQIYEVVQYEAKHHDLLMNVTGPGAWTDYGTVVVGSYGLSESLQRSQIAYWAVAPSPAILSVDLRSVDNAARSLLLSPYVIAVNQDPLRSKASQLPQKNNLDVWTRWVMPRLPSGDSSMVLMVHNPSIRGGPLAFEITVADLGLHNPRGYVLQDVLNNNTLIGLFYPSQKLSVAVPPLDVILFKATITDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q603</accession>
    <name>A0A9D4Q603_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q603"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="22649" checksum="D8CD77825F965094" modified="2023-05-03" version="1">MPCSLSRILGHGVRICKILRAEWQRQARLHRDSLYLQLHHLDRPSTAKKKWRELCVLIDRATEFLWQRMLTTLRDSTPKKPPQPSNRVHIVGEIALPEEVNQILGLGPKFAVEPRKTPHELLTLVRQVAQRMPEDESNRCVSEEEWDSTLQNAELLPQLPLFTVTGQRFLPLSCEPIGAVKLGVTPPPTGSACYVALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6B6</accession>
    <name>A0A9D4Q6B6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_008435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6B6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031088"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036641"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="919"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7968456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1251" mass="137521" checksum="D441E9FEBBBBA0E8" modified="2023-05-03" version="1">MVCSREYRSLSKTGVGATSLLTLATAVVARASFSAFIVLRVLEGIAEGVTFPSIFAIMARWSPVQERSFLLAISTLGSVLGTTVTLPVSAVLCQYGFAGGWPSVFYITGLLGCVWFIFWVLIASDMPEEHRFISEEEKKYIIESRDATFAVRKPVPWASILTSRAVWMIALIKFCGAWSFYTLLTELPSYLADVLHFNIRSVRTIIPLFLTTCYVLMYIQVFNGNRLNRYLLNLVCIFILHSGLLGQAVGMVGATFAGCDWMLAFAMLLVASSSSGALYGSESVLPVDIAAQYAGAVMGFANCISNSAGIFTPLVVGYLTESSESIEQWNKVFFTSAGVVVFGAVAFLLFGKAEVEPWARGDQEPLTMSNNEKQCLIYFTNVIQGEKQTELSPVSIADLGSYLLSAQVNIRRHIKSVYGGDLVEFFKRFPEIFQLEGTKHVYLTSDIMKKYGVDELEKMAVDFLKSKLKAMNAYHFSPVPLMALRKCLGEAPLGVQALMAKNYPAKDMRRLLQAYPDIFGVSNSGNVYLLGEAPRPLDDCNFQNYWSSDTSCLDGEISQDEADAVRFFRQVLNSPGIELESCSVDSLFAQVCEAPDNVQHFIKSNYTEVNFLDFFRAHKSAFSVTTGSSPPETLDGNDDEESDEEEFPPLPNQENDYLEKSSDDAWEPSHGNGDALAEVCVKLAAEDIVEVSNFHGTLRRNTERLFQCLIPDIKALLEFLHRREEFFVLDKEHFIVVPRSAVPEDTEEIAQMLEKELLKCTDSKAPLFSVLENLKDEGFDHHFSSSTVLKAVLTRKDRFEICDDLLLLIEEQKESSGKRDSGDHGDMGSGGTRTGIKPEKTNCTPVNGMGWIISLDGESGLLAATFGSSDDYAEVIFKRDALSATSTNYNELIVGQEVEFIAVKDNDESEWVIVELKSAGSTPCGEEEKEGSEQGKRAHPSSGGKHRLDISDAASDDNASTNGDDCIFYSSASDSEPVKLAAPPLTDHDTEKVKSPNFKNLTTEEVVQNGNAPTQEGTLDDSADTTIVDDGYDDCDWDTPYDRRIMDLRPFPMTEAFELCEKTIKCANSEEQSPQDLSADDESEQETDYEISPSTSPTKQSVKPEGNHLAAGDNVLVSHSDTDICSHSEWCFDEDLPFANATCDRPDVAYSIPATVALVTPTVAILESTVRGVPVSLIADPAATTSRDWSELHVGKKVAARALGNIEDSTLLLVVKLRPLWRKAAQRATLPDAATQTISTGPVLSASLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8C9</accession>
    <name>A0A9D4Q8C9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8C9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030388"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12153" checksum="44C81417E226D8B7" modified="2023-05-03" version="1">MEMLRGLVRSVVREELQKQRPGQSAPMLSSLADVIREEVRQVVQEPQTNAHTGAPLQRQPGMSYADGLLRGTPGPADVAATTPIQHPKYPSTLQLPRESKQKERYLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8E3</accession>
    <name>A0A9D4Q8E3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8E3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027351"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="82" mass="9248" checksum="5D5140AFEC7A545B" modified="2023-05-03" version="1">MRIPHVRRFGVIPLFRPPFAGGRCPTTCGAAEVLYTRDCLSNLEAYRHDIPADTYEGCRPAAESPKLAVYVDNNIKELELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q920</accession>
    <name>A0A9D4Q920_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q920"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057864"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="20517" checksum="20E1BE7549A6A705" modified="2023-05-03" version="1">MSHVGGECGVSRTMNRVGCNNRHPCRLPKLARPSVAPRRLLYEHHELACGFAAGSAQDSCDVDVDGAEELMPVALRDTLRGVRFDDYVEVDTSASVCGALTDEDIIAQVAGAQPVAEEPEGEEDEDDEAPVRPSASAVMEALNVARRFFSFEEGEEDSLRRVCALEQRAAAVAFREKKQMVITDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q994</accession>
    <name>A0A9D4Q994_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q994"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="249" mass="27148" checksum="13642DE0949546D5" modified="2023-05-03" version="1">MTDTQREDLDNMDFQDSAAHSFPTPSGPSDQNAGIDSQHQADGAWQTVLTLRKKKALAKEKKAKSLDFSGTLNHQQASTGEATGKPKHKPTYRRLPPLPKDDFKIVVRPHQGLPVKNLTSPLLADAVIAACGGQISGDQFLLRIKPGSNIFIMSTPHQTVGDPVRRITTLSINGRPHSVNAYVATSEGTTKGVIHGLDPHTTPEALKTNLRVRTQGVEILQARMFRNTKTAVITFFGGITPRYVYYNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAI6</accession>
    <name>A0A9D4QAI6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAI6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042737"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24359" checksum="F4109D653C1CF723" modified="2023-05-03" version="1">MPTCLLKFYASLEGLLRPQDMRTGSAVSFAPKLGDKSASTRNAFTSHTWGRRQEDLMLPWLPKKGRQRPPQGQEVVILGNVAVPAGVKKVLQNGPKVCEHPNLDKVELLGLVRGTVGRAKEDEVGLLVQEGVQCLPQDIKTARQRSNAIVAGLRRADARQTPSADTQPRAGRYAMDATGRPRCTAFFLVGARISVLALLLVLLSKTAVEAVSCKDEHNQDVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAS7</accession>
    <name>A0A9D4QAS7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_021165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAS7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028130"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7973090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="486" mass="53338" checksum="F744C4F3856875C9" modified="2023-05-03" version="1">MPAIPMKDGLGVTVLRRKYSDRLPKRVGQKQQRGGPPLSPALHDALMASTASSQASGQHIHSVDHKEDEQARKRLREDDAQSRASTEDNEEMDQAAFTVVSYKKKRAAGVPVIFKPTQPNRSFWKVNPNLLASAVVTTAQEKVLSHRLNKDGSLMVTMSSVPAANRLLAVTDLAGIAVEARVPYSYSATYGRIQDVPVEYSDDDLKEYLSEQGVISAKRQVAYIPNEDGVVTETRRRSVILEFSKDAPLPSRVSFGFCSYPVTEYIGSATQCFRCQRHGHIAKYCNGPIRCKICAGAHTHKECTSRSQPRCANCGADHAASYGGCPKKKAATLARTMEQFQGKARKRREPPPNPDVIFTSTNQKQQEQQIQRSDTTSKKSFASVVKGNQKRPSSAKSQEKSSSDPDASQQQMSPKSQQNRKSQEKLLGGSTIQDISSMLIPMMFAAIKALLCANPSLKDIPEVQAVLAFEPLVTTSPTAQRRGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBC3</accession>
    <name>A0A9D4QBC3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBC3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="500" mass="55256" checksum="AFCD9F9D1095AAB8" modified="2023-05-03" version="1">MGDGTAIGSTLLGQDQTAKATPEQVTTPWFDVTETGLDSTSADRLARLPPLSPTPCEANALKLGLMWQWESYGLPSYSNVFMGQLQVHEPHCHVVKGSAIRRHFNSSGCEREDCGGLVAPIFPFHRGFERGSVQFRFYATAQAVPDGARFLVLPFCFEKQGSFTKAAIYILSFLRWPWGNMSISADTADDAGEDNVRQLFKWYGSTTVVPGEVELNVVLHVTNCSESANLKKGEPRLGVVPTKGGVAVEFWQPWENIPANKADQHFYVPAACFAASRAMSFEPYLVSTVLAKINNYGLFDNVERWVFEGPAMTMGHTGLMTVAEARLRATRCPAGEGQNNSIQIAGSPSADDSIEVPLLYRCWGAPGNRIEQINSHDAWTDVEFWTDSEICIPDITAISQVNSEFYSFENRFGHTSICTDASLLTAYQFLISEKFFTGWHVYHATIGLSYSTISQTQQTGVLGRGETNYFAQLFNNLDVEPTDVQLGVTNFLEKEFEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBS8</accession>
    <name>A0A9D4QBS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">10-formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="9">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_003026</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10181"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051509"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="16">
        <location>
            <begin position="307"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="602"/>
            <end position="605"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="635"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="655"/>
            <end position="656"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="809"/>
            <end position="811"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="13">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7975530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="907" mass="99581" checksum="FE38062A53C60926" modified="2023-05-03" version="1">MRIAIIGQSAFASEVLKLLQKNGHDIVGVFTVPDKDGREDALATTASACGVKRVLKLARWRAKGAGVLPEVMCAYEEVQAELNVLPFCSQFIPMEVITWPKHQSIVYHPSLLPRHRGASSVNWTLIEGDTKGGLSVFWADDGLDTGPLLLQRECDVLPDDTVDSLYARFLFPEGVKAMVRALEQVSGKEYVRKKNVVRLSTILGSRFVLEAIKRRIWEQICSRRPTQATRVYGSSRWPSGPVEGARPVSVEGMSRPGLVHEQGLLLCGCDGTWVNVRQLAPEKTGRVSLASRFGQQQADGEALELSQEEQALVDKLRDIWKSILRRDVDDDTDLFECGAGSMDVTRLVEEARDSCGLQLAAEDVYLASRFSDFVRVAVLKARGQGSGGDDVSYDAIELEANGRSIRVPHQLFIDGKFVNSSWGRSSEVVNPTDERVLCRVESASAEDVDRAVSAAKAAFEQGEWGRMSARDRGRLLLRLADLMEQHREELATIESLDSGAVYTLALKTHVGMSIDVFRYFAGWCDKVQGSTVPVSHARPRKNLTFTRWEPIGHHHINAGIVQWAINLMRSVCGIITPWNYPLMMVAWKSAACLAAGNTLVLKPAQVCPLTALKLAELTLRAGIPPGVFNVLTGSGTVVGQAMCGHPLLRKVAFTGSTEVGRAIMSSCAAPHLKRVSLELGGKSPLIIFADCDLDLAVRQGLNSVFFNKGENCIAAGRLFVEDSLHDRFVERVVAEARKIVTGDPLDRSTWHGPQNHKQHLEKLVDYVQRAVAEGARLVHGGRRLPRPGLFLEPTVIVDVEDHMAAAKEESFGPIMLISRFRDGDVEGVLRRANATEYGLASGVFTRDLSKALRVADALQAGTCFINCYNKTDVAAPFGGFKQSGYGKDLGHEALKDYLQLKCVTVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBZ5</accession>
    <name>A0A9D4QBZ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brinker DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBZ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041852"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14694" checksum="37554B141242811F" modified="2023-05-03" version="1">MAPNGRSHYSAAYKRKVVLAAESSSNIQARRDFGVDKKNVRRWRGQREKLFACAATRMAFTGPRKGRHPEMETALANFTQTQRAAALPVTTEVLQATARALSRKCGISNALDGTKDCALFEDSDKEISDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD98</accession>
    <name>A0A9D4QD98_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysosomal-associated transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAPTM4/LAPTM5 transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD98"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056085"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004687">
        <property type="entry name" value="LAPTM4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03821">
        <property type="entry name" value="Mtp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7975667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24422" checksum="3822D0E2FC02AE81" modified="2023-05-03" version="1">MMLRPELVEKLYGNNGSATQLSGSFITRFRPSVYNHELSDMASDPKLASIRNEDLHVALAITVCTGVVTLLLLYGTIWGQPTYLMPFFCLQVFDFVLSALTVVGYFSYMPDVRRLVASSRELPLQKELLRLDPQWLCTVVMVGFVACMMIKAYVMGIVWSCYKYLRLRQEASLPDVESDSEVLPYGQALLPPDYETATKMPAFVPVYAPPPYPSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDE1</accession>
    <name>A0A9D4QDE1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDE1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031559"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="14028" checksum="6971153E931D3443" modified="2023-05-03" version="1">MDSVRDSVDGSWNRLHLLTGQDLYNIQRDFNINCDERLHSDDYTSVLLWVEKMKLLDDNPVLFFKQQGTTDNATVLQRQDTELLDDDDFMLAMMTNPQKELLEKLGSDRLCVDGTHGTTGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE99</accession>
    <name>A0A9D4QE99_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tumor necrosis factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE99"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045345"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7976681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43172" checksum="18CC204526AAE813" modified="2023-05-03" version="1">MAAAIECHPYTVTGFGEFLEWRTLRFVQPMPKIRVCRLCGVVSSVARLLPCTHVLCESCEAQVADRGRPQCPIDGAAFEREQVTTMPFAKRDLGEYHVRCINDDVDVSDGTDGCTFIGKLAALEEHYLAHCVHGRVRCSKCGRSVFRKDIVDHYVDCAGAEMDTSPVEPVDDGKVIIDAAEAKRLAGTLKDLQHGLKDASLGTPMATANFASLRRKAVSLGDFLSVLDPDQTDVPRHDSWCGSEAGSSTICRFRGIEAMRKSGETTLALEEPCRLLGYTFTLACKFERSRGKLSSVSFLFALRSGERDDFVEWPFARRVKLSMLHPKKQGKDVPVELKICQEKHAQSLRRPQPDDPQNGILSEKITWKYVEKKELVGDDCLLVAVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEI0</accession>
    <name>A0A9D4QEI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_012332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050745"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="145"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7976342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="286" mass="30788" checksum="2EAA43876329556A" modified="2023-05-03" version="1">MHSVGICGSDVHYWTHGAIGNFIVREPMVLGHESSGTVVKAGKNVKHLKPGDRVAIEPGVPCRYCNFCKEGRYNLCPDVVFCATPPHHGTLTRFYTHAGDFCYKLPDHVSFEEAALLEPLSVAVHACRRARLQIGQTVLICGAGPIGLVNLLTAKAMGASRVVMTDIISSRLQMAKELGADIVISVASKTVQDTKQEILCTLGDLPDVTIECTGAESPTQLGMVATKSGGTLVLVGMGPNEVKVPLVDAACREIDIRGIFRYANWQGQRRGNPQKANVDNNTHCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF01</accession>
    <name>A0A9D4QF01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035881"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042319"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7976627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="449" mass="51235" checksum="86E24019902B0A95" modified="2023-05-03" version="1">MSTSRRRNYCCVVGCRTGYSRVKNRPKLSLFGVPRDEERRRLWDQNLNRADRPLQVTDAICELHFEQKYILRHYVHIIEGREVHIERGKPELRSDAVPTILPHLLECPDEQPTPEQSTKKRAASPPACEDKPSKRTVLLSVEPQLRFEDCESARQSDNAFELGDVVRPNDHWAMHNFCHYDGIAYVSASLSGELVSIEKTVLMNYGTDRSEVICRTYVRKTLVSEKVAYNLEDAKQVLDCAESLHPCRGAGRARDFTYDVLTKKLEQQISHSDGLVFSVTCKGAVKRQGFVDLGEFTKPEDKYQQCDHGMVIMFVPFAGKWSQIVGVFATKGNAGLFVDHITCDGAPWNRKMWKLAGVLASSKEINGAIQHPVSVHPVREAYLRDRSVRTLKVMPNLTETHLEPNSFEKMRTTFAFQLFGPYVLRGLAFYKEDIERRCGSIEATQRFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF60</accession>
    <name>A0A9D4QF60_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M7GpppX diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF60"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039378"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38496" checksum="5D50535CA631C648" modified="2023-05-03" version="1">MAAAAGTEATLATKRAANDEKSSTNRRKRRSSIMPQPLSNTAAAVVVLEKTPFSRENYELVFTADTKLKEDLPQRRLHIGRASSVRPHEGAKREAAPFVLTRIRRADLDPDRGDIRVCGAHFVSGYSTCHEDPAPYDRVNVPCLQKDEADAAAVPESIGTGSGDEPPPEDESRMERSDPGLTATVICPATQKHVDKYLFKPQHMITETPKLYKEVTEPYITSQQLSLQWVYNILEHKKESERILFEDRTRKTGFILLPDMKWTPSSRRTFMCSRICHKHGIRSLRDLTADHLSLLRNINEKVNAALLLQFGVPSHRLRSYLHYQPSYYHLHVHFRCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFR3</accession>
    <name>A0A9D4QFR3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFR3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="75" mass="7878" checksum="B552FBD977AC3E34" modified="2023-05-03" version="1">MPRAGGGSTKGEEDLLLAGWDPGVRVDVTAPQHLNRPDGANPGTLGPHFTVGGRIAWNINLFIAYKRAAINRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHQ2</accession>
    <name>A0A9D4QHQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cement protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028739"/>
    <dbReference type="OMA" id="FPGCPPC"/>
    <dbReference type="OrthoDB" id="6516831at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039349990" description="Cement protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="28473" checksum="D617734790D51A52" modified="2023-05-03" version="1">MKTTLIVFAVLASSALAEDSKKLTEKNETAVEGRGLFFGSNNGFPGCPPCPCGYGVGAGGLGGFGASGVGLGHVAGPALGLSPGVGLGSGVGAGHGVGGAGLGSGLGIGPATEVSGLSHGTGAGHGAVGVNAGSGLGLQHGAASINPAVGAASADLGGVGLGASGGSSAVLTPGAGVGSEVVVGGGPVVGPAGGAGLVATPVVTGSGIGAGVGAGHQSAASGHSGFQTGSGFANKAGGHKAGQGSFAYNVGGSDSSSYGHSSSYGDSKSFGLSSSEGSRHAQGQGSHGSAFNKQAAGSEASSHSSGVKTKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHZ7</accession>
    <name>A0A9D4QHZ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase 25 family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHZ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047571"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21748" checksum="D413B9628BA062CC" modified="2023-05-03" version="1">MVKCANMIENQHRIALIFEDDIRFEPYFRTKIGELLTEVRHLDWDLIYLGRKRLSGSKEPLVTGSSRLVHVDYSYWTLCYALTLAGARKLVDADPLPRMVPVDEYLPIMFDKHPEKVWAAHFPRRDLKAFSVHPLFVHPTHYTGEEHYISDTEDSVVVDTLNTTDSDYGAASVLAPADVASEPETSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIM1</accession>
    <name>A0A9D4QIM1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIM1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051816"/>
    <dbReference type="OMA" id="CCLCCQD"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="11977" checksum="1FCC0CAEFEA85BDC" modified="2023-05-03" version="1">MSYGYPQAQHQYQPPPAPGFAPPQQAPPPGYPGYPPAPVAEPYFAASAPVGGTYQPPPAPAPQHLYPTQQQPGGYYAPPAPPATVIVKEKEDSCAKDCCLCALCMGLCCLCCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKB6</accession>
    <name>A0A9D4QKB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040631"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="3">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="389" mass="45337" checksum="F3E4EADB8E59D61B" modified="2023-05-03" version="1">MITHAKVRYEDDRKLAVVDIRDIENFHPENAKDFKSKFFYSVKWTDPDGTSDFYRARILALGESEEDLEAEGRGRQRLRFERMAYSPDGEDEDDDVEPERPAKKPSGPKQELLDMLKKKTDDIQQREEAALKKQKKRPTYDDRGGLVTELKYKVQRLEGLVERKCKKIEELRNKNEELEQEAMKLRQLNMRLQEKMLTAIDEGTGYSRASCSTKSGPDHSTREVDIDSMDVIPREKTPPQDDYARKENAMVDIGGGLQINSSAWHHIQGHQKDSLFVKDLLLGIWPKDQLKNRSLQGKRCPRFPDRPAKAPLTPWKVEVMRDCYRRRLQRQGIPETLMPAALKQLNHFVVEKLADLERLAKRQWKNIRVKLDHQLCTSVLQTVDQLRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMN2</accession>
    <name>A0A9D4SMN2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMN2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055415"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="232"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="579" mass="64081" checksum="B52B4A8588A37992" modified="2023-05-03" version="1">MAVPVMYPSPQYEMESPATPGIVKTPPTRVLRSLFPATDVVQRPVLRPGSEPSPPTLARSPVTSPRHMNEPHSSAESPMEVVSPQGSRVGYSFDSDETEPYAVQENRPWWQLLWMLCSLVFITVFIPTAVFLITYQSTGRAPPTFIVVAGVATSVNVTSSALRTSQTTTDLPRVTFDPVEGFLLQPGESVQDFCKRQMERDRSPMPPPGRLPTTMIPNSTTKDIQLRPVICVFNTKYWRLQDAYLPTLMPLHYCSALLWYGYAVHALNGTIVWKYRTAFRYLNALLNMKFQHRLLHRGYNISVYFALGGAREDSANLSYAAGDPGTRRRLAKAVWDKVEDVLTPWTGVNVDWNYPGDPCNPGSGTGNLFFELIKELKNYGTGVMISIPPVKSRLSAYSLQAVVSMVDYIIIKTHTAFPSLRNVVRCSGDHRVAADVFNAALALLPTWDDKLRLGYSISVAPETFLAPVAQLGAPALGTKQWDNYTRQPGRTSYASVCRETPVIRTSSHPLCLMVARQIDSQTVATFSDEQAIMERMNLTYSDNMAMAPVAVFDIDLDDFTGKCGNGPSPLIRAVAIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNY5</accession>
    <name>A0A9D4SNY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_013589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050102"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7935790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="30498" checksum="A037855AB10C0706" modified="2023-05-03" version="1">MANAAAISKVTKKSLIVASWDPMLHLNEQPTPSCLTRVTRDIAEIKADPLPGIFIFPEESDLTRIHAIVVGPEGTPYEGGFFHFFMKCPPNYPIVPPRVRIMTTDAGRVRFNPNLYACGKVCLSILGTWPGPAWSPVQNIGTVLISIQSLMNEEPFYNEPGVSTMPVFSARYSDRVRHDTVRVAICDAVEACLQEQPPYPPYLVGAILKTFADSYGKYEDMVKRLVQLNNSWQLTRILGVTATYEYEPLLSRLRQLGPRVQDKIAADAAAEGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP58</accession>
    <name>A0A9D4SP58_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP58"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="142" mass="15363" checksum="6E2F1C3B96B04922" modified="2023-05-03" version="1">MAPFSIADEREELQLDIEELAAFYLSLQAYRARVGDAVAIPGSLLNSDSLFLLYYVYNNCLAVSNGKAGDDPKGGGGYGVNRAPSLDSRRRRVDSVAAMFDVFEGLGQLKDFEYDMKLKPGAVGVVVPARTVPVALQDKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPR8</accession>
    <name>A0A9D4SPR8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPR8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9152" checksum="103EEB85058B56D3" modified="2023-05-03" version="1">MGRSIGDRADVQDRERVIGDAVGSVLKHASRTVSGNEPIKSAITFLKKEALQVIPADNEDPGMKESATGRVLPPQMAHFENLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQP7</accession>
    <name>A0A9D4SQP7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047114"/>
    <dbReference type="OMA" id="SYEYNEH"/>
    <dbReference type="OrthoDB" id="1925236at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051868">
        <property type="entry name" value="ZN346_ZMAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144">
        <property type="entry name" value="ZINC FINGER PROTEIN 385B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7939966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="24666" checksum="FF98593636B2A538" modified="2023-05-03" version="1">MPSTPLSCKECCMQFTGPVPYMDHMQSAKHKKKMAALNQTDAPAAATNTKAAGAVKGTSILRHPLPFACKLCNVSMNCEAALMAHNKGKRHQRALKSQGTIQESTDASSATPLDTSTSSVTGSTQAQSSGKDLSCEYCGIVLFKSMEYKVLHLETEAHRKNKQWAVTQEGYKSEQRDEPLQKRLKTEHQEDEVTGGPNGGYDEYGGSYDQYSEYPAGAGHYDGYGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR05</accession>
    <name>A0A9D4SR05_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR05"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050619"/>
    <dbReference type="OMA" id="SGCIRRQ"/>
    <dbReference type="OrthoDB" id="6486101at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF69">
        <property type="entry name" value="GEO11767P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039291004" description="TIL domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7943404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18183" checksum="684E723460D4D135" modified="2023-05-03" version="1">MKAFLLFLTATVATCAPSTDSDDAPKLLNFGPEPQECDLNEVWKECVSSSCAEASCSRPIIGPACTADCRYGCYCADGFYRNVELKCVALDQCPQQRKTASFPVPQCRENEEWKSCVSSSCAEATCESKTIGPGCTPDCQQGCFCSQGFYRDSQRNCIREDQCQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR07</accession>
    <name>A0A9D4SR07_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR07"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12237" checksum="6BBF0137CE3CDC59" modified="2023-05-03" version="1">MDTLAGATTQEKGLLPFDSAHSKTIKRAIALMCLESALEKSCPHQMMPSFENQLVRTVLLVGRVEILAGAYVGDVGRNFVAQASKRLQRTSEEQQLEPEGEKVELDRLPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR31</accession>
    <name>A0A9D4SR31_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR31"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15855" checksum="2E8662D47F6755EC" modified="2023-05-03" version="1">MGSSKKSRTSKSSSRRKRRERRFEEAAAGPEEDPKAVLQSERRALLWATLAAMLGFFLWIICIGTEQWITVAAPESGPVYVNRTKSFFFYANMGLFRMCRTYCAGYGQWQARNRRDVFPSEEAIRQDMEIDRTILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSG0</accession>
    <name>A0A9D4SSG0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSG0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055479"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038461687" description="Nlr family card domain protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="71186" checksum="49C54A19B98E8D89" modified="2023-05-03" version="1">MHAAALLLDLLSHHGCIVSVDLSVCISFAHPTGDKHKLMCDAFRKSPSLRKLKLRLRTSTTTLSQSFIETLPHLIQLTDLELSYVPFDRMSLKALSEFLASTRALTTLVMTNQDIKREDTVLVVQGLKRNATITTLSVNTSLLITDSPHSGIMFSDYLRSNETLRTLSVSSCYPISSTDICPVIRALFHNDTLSELNLIDLELDISNTESITDMLIQNQTLQGFHLIECFCLYPGSYVPCGDPKLVALTNGSFMTSRWLTALAENKTLQELTLCLNWINPDDCGSFFRMLARNTSLKKVTVRNIPDEHVTEICRALRETDVQGRFYVGKHRVLKDTVVELPECKELSHISVGNHDDDDIEPLLTALRLLPACTHVKSLCLRIIDEYFNSKVSSLIAQYITNTTALRELDLELIVRNLNAADRVELTLLQALSLNTSIRRLSIRDLRFGDTENQMLVDMLDSSRTLCYLSVQPWHHKSTISLTRKLSQNLSSNYKLLGVHLPRDQASSGELFTIEEVVRRNLSLVTRAAHFVMGTRHRYCVAAAELVHFNPGLVEKVQELASIHEDEAASRIKNCLKSITELHDFMCLAGVVKHSVSCHRREDGQKQLVDLNRDCWLNIRQYLKVGDILDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSM0</accession>
    <name>A0A9D4SSM0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_007422</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSM0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031761"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7947025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="403" mass="43530" checksum="19584F23EDBA7111" modified="2023-05-03" version="1">MISSSTYEEVALTVSSAEEAQAGGGMATVEGRPAQYGVTVQQLRELMETRGHEAIQRIQDEYGGIQDLCRKLYTSPTDGLSGSAADLEHRRATFGANSIPPKPPKTFLQLVWEALQDMTLIILQVAAFVSLVLAFIEPEDHDAAAHGKPKEPGESEAGWIEGVAILVSVVIVVLVTAFNDYTKERQFRGLQSRIEQEHKFAVIRGGEVHQIAVTEIVVGDICQVKYGDLLPADGIIIQSNDLKIDESTLTGESDHVKKGEHIDPMLFSADEEAAMSGNSHLGNITANTHVEPARADSIVAASSPAEDSNPRKEKSVLQAKLTKLAIQIGYVGSTIAVLTVIILVVRHLIEVFVAEGRPWRSSDTQHIVNCFIIGVTVLVVAVPEGLPLAVTLSLAYSVKFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSS8</accession>
    <name>A0A9D4SSS8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSS8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="77" mass="8436" checksum="0009B55D44E633A9" modified="2023-05-03" version="1">MDLEKLTAVGTQLGLTGAELSRWIEAQQAKQRDERAAEREALKEAAEIARLADERQREIPPAKATASGRSSECTCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU22</accession>
    <name>A0A9D4SU22_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045257"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="22333" checksum="F172C23AA05D8BCE" modified="2023-05-03" version="1">MVEALVVTMEAVGLEDSVVTMAVPVAEPGQPTPYNFGYDVKDEYGNSQSRQESGDGSGTVKGSYGYTDTNGIYRQVSYVADQNGFRAVVKTNEPGVGPASPADAEFIVEQPPAGVVSQYAGARGGGGYGGGGGYGGAGGAGGYGGAGGAGGYGGAGGAGGYGGGHHGGAGGGAGGHHGGAGGYGGGAGGYGGGAGKFGGGAGGYGGGAGGAGGYGGSAGKYGGSSGGYSSGASGAGGGSGPWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU70</accession>
    <name>A0A9D4SU70_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lactate/malate dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU70"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051391"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="337" mass="37769" checksum="2FF3A8F39E3F424D" modified="2023-05-03" version="1">MRGRRSSSVSTEHQREFERPRRRADRRPDELNSEEEPFVKPGTMRPKPPPPQIAKATAGDALKEPIRVLVTAGDDELAYRMLIPLVRGGRVRRGPAMVLHLSCSPEEDEVAFLNVDFAFLNDSCPLMGIGPVREGVQTYAGHGKALSAHAKKTVKVIITGHPDQHNTTSASETGRHPNKIVNMIVWGHRGDMLLPDYRRSVVIKKAKRYKISDLVSHDYLDEGLPEDVKIRDDLVQKLTKHPGILSRAKAACDQMRDWWIGLPAGQFVTMSVLSDGVYGVPPDLVFSYPVFIDNARSWKVVQGIALDEKLRHCISESAKDLERERDEAMEICTELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUC0</accession>
    <name>A0A9D4SUC0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030940"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039637719" evidence="1">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="216" mass="23609" checksum="534E3099EA4CAC2A" modified="2023-05-03" version="1">MALLWTALLCALLKVHGSQATASKVVPTARWAVSEFRRGRALLQGADTVDGIESVTWCFAACLKVPTCRAFNYGKAGCQMLQQELCHQAGLKLTAEPRLNYYDLQDRALDERMGPLWKTPFCSEDGFCSPTCEPLPVDGYSLYPGALEGGYFRLSTTEANFSRASSECALDVGAELAYVADGDTNRFLRELMRRAKVRSAFIGLTDEQQASNAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUW7</accession>
    <name>A0A9D4SUW7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_018358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUW7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="621"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7948077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="692" mass="76320" checksum="13BEDB967E6C0A8E" modified="2023-05-03" version="1">MMPTRYRAAVTIGVVGVLSCIGVVILSLTVARDRPHPPRPDCNTSSCQDSRPDFEASRYSWGAAASTECRSFYDFVCGRHYHARPLLHQQAVLSLATRLNASLYAFPAISEALLRGSCPGHYALLALDLYRACTAPTADADWEHVVHLLRSLGLAGWPLVRAQPLDLSPWDLAGVIDFRIGVFPVARLSLRRHYGRVTMQLDRTPLPLRLHQLALPLRELSSYVRTVEKALGLLQSGTTMESGESSDAAKQWSAAAASIVRLEQALERAQPRDAFVYGARLIRLGDLPASRHWNWAEYVAIVRNDSALLAQANLTLLVHEPEQLALTTETLGNASAAVIFNYFGYRVLLHLAPLLPAEAHFLLPLAPWADAGSPRLVGCLRLLAHLHPFAFRFFAGLQPGQGQYHPPADGGRAYALFAAAQRATAAVVETLPWREKGVGLRRANLLLQARLVLGGNTSSQREQHCLRGPVPERTNGGVLETLFRVQSARPNAFWLAASPDDGLDSRHQVEPFSMRADYFAEPNVVYVSPALSTVLEERPLGDVQAAAPLVEALLRAALPGEPQELLRVTPVQLRCLARRLGVSPYDAHMPEQLRELVQPSALLALSARVSPVPSVRFADQRKYLGSQLFFVHWAMTLCDSPQLQKRLRRYKLVPTRHRVDVTLSNHAAFHEAWHCPSGTAMHRSKACPPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWJ9</accession>
    <name>A0A9D4SWJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051329"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12549" checksum="807199759B64E89F" modified="2023-05-03" version="1">MLLSDYAKSLSDPERRRYHIKVAKCGSDDPLALSDDQFTNDVGCYPSVDRADINDYLVHGTSFVTREQLKSYKSLEAHNYVTSGLVEPPRAKTLRDGNIVVVSKVGCCSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXH4</accession>
    <name>A0A9D4SXH4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXH4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039094"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="409" mass="44881" checksum="FA02125EC326D875" modified="2023-05-03" version="1">MCSNSCDCEDLNESELALNADADTSSSDNTCKTCGDTAHLLLRKKDAYCKTCFVANCTHKFRATLGKSKLLKPRDKVLVAFSGGPSSAAMLRLLRDGFSEDAHKKLLFDPRDDVTDLMKESGFPYYTYHLDSLYSTERLKLESSTRHAEVDDGEGAARTAFATACESFKALTDRESFYRLCLRRLLLRLARDNGFVKVFTAETGTLLAATLLSTIALGRGAQLREEAGFLDDRDPEVLFLRPMREFSSKEVELFNQHCNVRFRAQTAPRAGCESRASVFRLTREFVNGLQENFPATVSTVWRTGDKIESRPRARALAAGPSSSSRCCMCGSPLDTVDVEPCSAVAALQLTRDVSRLRVAEDAESTTSDVTDTHDVSSSNFCYACQALVRQGDTSSLSVLCDVVGTGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY47</accession>
    <name>A0A9D4SY47_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_010151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055722"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="819"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7956510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1251" mass="140430" checksum="ABB7B513E61FA4F5" modified="2023-05-03" version="1">MGNQLAGIAPSQIYPVEHYLTELPDFTFEKNLGSTRFFKVARVKSKEGLAIVKVFAIHDPSLPLAPHKETLERIRRVLSAVPNALPFQKVVENDKAGLLVRQFIKDNLYDRISTRPFLNSIEKRWIAFQLLHALAEAHKLGICHGDIKLENIMVTGWYWVLLTDFASFKPTYLPEDNPADFSYFFDTSRRRTCNIAPERFVKTLNPDSSHYLPEEGIGTGELTPAMDIFSLGCVLTELFTEGHPPFYFSQLLSYRSGEYSPDKILEKIEDDMIQHMLQKDPSQRLSAEQYLDQQRDRVFPQYFYTFLGDYIKEFATLALSPDEKVARLRQDIHAILYSLVLPKGAQAGEASVGCEGDHVPPSTLSPSPAGSDGLCIVVAVLTSCLRSLKHCSAKLQALELIRELCPRLSSDIILDRLLPYMLYLINDKYPRVRAAAVETLTTCLTPIDTLPRRYMSPWTVLCIVRMALAENIALLAETALRFLDLSTQHEVSSPDGTNVEPPVQAQHHHQGSYDTELQALQHMVQQMVSTLLTDSNNIVKQMLLEKGITRLCLFFGRQKANDVLLSHMITFLNDKEDRHLRASFFDSIVGVAAYVGWQCSPILKPLLQQVSGSNYVFLASPALLKAVQTIQTAFFFPICFGRLSACSNKNLWIRQNTVGFVCAVTKTLSLADTQCKLRPMLQPYLKRSVVEMDKEVAMLNALEDPLPRSLYDYVVKLDALPSLLEDLRNRQVMRSIVRGKHQPPLPNVDHQLKSAMKEHLAKIHKYKRSASESENVDAKLRGGEIDLEKLYMSNRCHSTDLLTLKIGDEPSQALLHSRSYRKKGPPIESPQVTMTQPLPQQHSPAGDGDPNMELHVSGAESAESAAPSENTSPKQPQKIFTGITIDTATVHCLSCQAELQLLLNKKRTEFAREQTVREAIDDPAREDRPLPPKWRPRGTLVAHMHEHKGAIHRVEVNSNKTSPLKTRSLDPHEDGCVVDLQHFDTGLQSVLVYATVYGSIIGWDLRSPSTAWCFENNPRHGVITSFCIDPQHNWLVCGTSEGKLICWDMRFQLPSTTVSHPAGKFELCARVRRVSIDPLYQSCVWAAVEGNNEVSLWDLETQARLRTLWASMSPPLSEKQASSSAPVHSVYSMYISPLECGPFMLTAGSDMRIRLWDINNPLASHVVAGSATDTLTPSFSYKSNLIDGTKVIQEVYSSRPRKDQPSSEQPKRYPEQPPTGHNDCISDIGIVQTSQTFIVSASKNGVVKVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY88</accession>
    <name>A0A9D4SY88_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin viia and rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY88"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028887"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15753">
        <property type="entry name" value="FYVE_SlaC2-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051745">
        <property type="entry name" value="Intracell_Transport_Effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555:SF3">
        <property type="entry name" value="RABBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="537"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7961169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="93366" checksum="72D1820324F26671" modified="2023-05-03" version="1">MEVSRIHRRPPSLQRQSSIRLWDLGWGLWGAFKFVLASLLAGPLRRARLLSGEPDTPSSLTSSPEKQSSRWVSKSSFKASQVCGGRRSWITWVAVLASPRVWLSAATGFAWLLVARWTSLINLTLRWISAFLAALKEADAKSTRRLEEELQGHVRGSTHREVCKDGGKSCAHCSSTFNLLFNRKLVCRECGLFVCRDCATYDSRDRGWYCRLCEQQSSPKSFSFKEECKPKTKDASASSDASGSEDGDDVVCDTYEELLVVAVINKAVEMAQRKYATDGSTGDLKNACEPDIIRTAKKDHIDVGCQSDIPLSDSGQEEEEFTEETESDEFFWSRVKEDPFKYIIEEKIEEEITEAYTESDDDRTRPLSDPEECTSSSRMQVPFPEMGVDIVTPYALDSDEEELEGDDVDGHEGSVKGSDDTPARIWTTCVQDWEDNWLFRQRKRNAALGAFRGGRYAAYYDPINMVIPNPSDDCGRVRLGSKDLDELSEMSEKLSVGSLELSSASDSEEDLGANEVFDKEPTIVAAINATSRATNAPDFTVAPHIVELTGDSWVQISCTVSGYPEPRVWFLRDDLPLPDSEEERFCVENKGYGEWCLRMQSPTPEDEAKYIAVAGNSAGRAHSSISFRLSDLKVKPASKRPVKASGSHVNNRQPSKSTVEKAESEGAASGESSLTYDNTSTFKNVDEQTELVPSVELLNAPPKPGTIAEREHAKWLNAVPLPNNPYSVENLSRRASESRRDSLTTAKTGSSFDTPLEDDNDEDGFCSPVLPSSYLRDYYINNPKLVAQVEASSIRRSSIQSAKSLTSSGDPEETLHSFEEQVSLKELGTEFIDVMTVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYS3</accession>
    <name>A0A9D4SYS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051288"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038646561" description="Cuticle protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="19602" checksum="7A356136220827CE" modified="2023-05-03" version="1">MAFSRSTGAVLLCCVLAFAAAQQPSLDGPPQPYSFSYDNTDEFGTRISQTETGDENNNKVGSYSYTDANGISRTVKYTADADGFHAVVETNEPGTKSSNPADAQYISNAAEVAPAPVAVKPAPVVVKATPVVHTVQAAPVAVHAVHAAPTFAIHAAPVALHHVSPVAVAAHPVAFHAPLTYTLGRAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYT0</accession>
    <name>A0A9D4SYT0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_010855</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYT0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030220"/>
    <dbReference type="OMA" id="WERQLEP"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000016">
        <property type="entry name" value="Putative Semaphorin-6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039307962" description="Semaphorin-1A" evidence="14">
        <location>
            <begin position="24"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="15">
        <location>
            <begin position="32"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7961619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="605" mass="67413" checksum="693E52BF7DB3ADDD" modified="2023-05-03" version="1">MRAASSIFWSFTVAVALVPSTTASWERQLEPKLFIEEYPHQLVRVFPAHNISDAPGEYLRLLLLDGDYVLVGGRNYLYNLSVHTLDQAGNISWTASGSSNPVCTDRAVPNDQNCANFIRVARHLSSQSLLVCGTNAYSPRCREYKYDPAQRNYTWKTDVDGQSICPLDRNSSAAVLFVNNRQIAALSARTGVPRAPAVLEAKPLRTRPEDATQLAADADFVGAFAFDDHAYFFLTETAPEKDHCGPRTAATVARVCVNDPGGVPPHDWMWTTLQKVRLHCSLNGTKPFVFTDIAAVSPIMTRWNKAFVFYALFRIQGSPFKGSAVCAFSVDDLIASINDGKPGREKCPTQPTVVKNETLFLQDNRPLSEREVHNYLSEPMLAHVGFDYHYTSLWIDPQVRTVSGKRYDVFFIGTSHGHVIKAINVGQNSISTVVIEDIIVFPGEDPVLDLKIVRRPGVVTLLVTTYHELVSVPLDNCNWTVRTCTQCVGLQDPYCAWNKDTTKCESLVDQAVPKNAVQEVVGGHSLECPDEFSKHMNNMKFPHGSDPWTIDNTASSGRATPHLYSAHTLGFAITFCIMGSIVIGFGIGYWYRHNQRKDMAYFNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYZ1</accession>
    <name>A0A9D4SYZ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056839"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF35">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="119"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="381" mass="40689" checksum="638AC7E991405F88" modified="2023-05-03" version="1">MDLSLPSTSSCGATAISCKAPAAPSPAALTECIQLRPLFCTLSPETERGGELPEEVAGGDMGLPEEETALWPVQEEGGPLSPLFSSLQDVSPLTPHHDHTPKGGLLVSEQAIPSMRGVCGLRNLGNTCFMNAGLQCLLSNGRLVSYFLARSGHASEREDEDSLTAQLAHLLCQVWSGSYSCLRPAPFKEALAQACPQFSDCRQHDCQEFLTLLLDTLHEQTNCAGRETRGSPSQGSGSESSTSSWETAVPLRGRHLPFEPCVGGKYSEAEESAVVGEVRPDSPNAATAVSACKPSKEHGCAGMQEGDLVNGRCSPPLAKRPRLDEGLKSDEQEQRAQEAWDEYTARNRSVVVDTFQGQFRSTQQTALAAVGLGLGQVLELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ66</accession>
    <name>A0A9D4SZ66_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_016215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ66"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028436"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032835"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048663"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="52896" checksum="68D79C8507E3466C" modified="2023-05-03" version="1">MFQNKTLVAVILPLPVIRYGWYYCFITECEDPKACTILLRGASKDVLQEVERNLQDAMCVARNVILEPRLVPGGGAVEMAVGHLLTEKSKNLTGVQQWPYRALAKALEIIPATLIQNCGGNTIRTLTALKATSALIPAPDHPPDEVQEVLAAIGHSTESSVFSTASAHGPSDVPAICTSSLTSMAHNTSATSGSTTATSPHALESAIDGDIVTPTIRPPIAEASPAMMSDEPVFPSTSALCASCQQRPASPSQSLAAEVPAPNHRWPNFRDAATMTDAPEDDVPGQHTPELTAYATPATEADIQHADLRTSPREPTTVGASTSTGSPSEPAAETTPAQLHHRFPAEPLTQDTIHPTKMTELWSSVNGGDGDASGLEEFLHADDAVATNEDFTDEAIVAAVTGAEDDSSDKKEPEPMQAKHAAGEGSNWSIDGETGNIVPTDELKVWEPLVVKLQAYKTAIETAILLLRIDDIVSGSKKKGKGDGDQTPAQPAPTEESMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZY9</accession>
    <name>A0A9D4SZY9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZY9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052341"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="11286" checksum="54D49AD029C1C3FC" modified="2023-05-03" version="1">MVVPYSLSSFCLTKVAHVFRSQRPYTIPNERDSHARNTKRAAEVWMDEYRFIFYDRKAVFNELDAGDLTERKKLREDLNCHNFRWYLEHVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1C0</accession>
    <name>A0A9D4T1C0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_017540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1C0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035721"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040783"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056197"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="13">
        <location>
            <begin position="95"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="14">
        <location>
            <begin position="448"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="13">
        <location>
            <begin position="507"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="13">
        <location>
            <begin position="646"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7962697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111783" checksum="1278A586C8EB9211" modified="2023-05-03" version="1">MRLRGAIVDVPVAPECQRRDYGRGSYVCVCNVTYCDYIGDIGPLQNGSAVAFESTKDGLRFAKTAIPLGRAPDDGNSNETLLIVIDSSKEYQEVFGFGGAFTDAAGINVKSLPANMQDDILKSYYAKEGIGYTIGRIPLASCDFSTRKYTYDDSPGDFELTNFTLAQEDFDLKIPYIKKALSLSSEPAWFFGSSWSSPAWMKTNNALEGRGFLIGEPGGPYYKAWAKYYVRFLQDYERLGIPIWGLTTQNEPTTGFVPGFRWQTLGFTVNNQRDFVKLDLGPALAEAGYGVDKLQLMILDDNRIVLPHWTDVVLGDPEAAKYVGGVAVHWYMDSFIGPWVLDKVHESFPDKFILGTEACTGAAIKPEDKVKLGSWERAELYARDILEDFNHWVSGWTDWNLALDTEGGPNWANNFVDSPIIVNASAQEFYKQPMYYALGHFSKALPRGSVRIHSQLEQPSFQVAMNTTATKLEYAAFKTPDSALVVIVLNRCWVTLSQRSASADLLYIANLNHRATGWTDWNLVLNTRGGPNGARNFVDSPIIVNATAQEFYKQPTYYAISAVVAECQKRDYGKGSVVCVCNATYCDFAGDVSLPPIGSAFAYESTKDGLRFAKTTIPLSRAPTQDTSANDSLLLVLDSSKMHQTVYGFGGAFTDAAGINVKSLPEKLQDDLIKSYYAKKGLAYNMGRVPLASTDFSERKYTYDDTPGDLELTNFALAREDLDLKIPYIKKATSMVTGPLLLIGSAWSSPAWMKTSNSLEGEGVLIGEPGSAYYKSWAKYYARFLQEYGNHGVRFYGLTAQNEPTTGFTPAVKWQTLGFTAQSQKDFIKLDMGPTLTEAGYGSIQLLIFDDSNSSLSEWSNVSDLVCSELIFLGITTQVLSDPDAAKYVAGVAIHSYTNESVGPTALDQVHEGFPNKFILNTQTCVGSDAKPEDKVLLGSWERAEEYASNIIEDFNHWVNGFIDWNLALNTEGGPSWAGHFLDSPIIVNATGQEFYKQPIYYALGQFRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1E6</accession>
    <name>A0A9D4T1E6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1E6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="19913" checksum="8AD79B8B7C895512" modified="2023-05-03" version="1">MLQSQRAVLTNRTLHRTRPIVMVVRIRAIGWQREPDCWGSDRYPIFLEFPTHGHSRLRRCCRVVHWDAFRKAALIPQDQSPQDLQDFLRKALDSATKTSWVDESRPAPDLQLLRLWRPGAGLNLLRLDRGRWLDWCASLDPRHAQPLSGVRFVQWRRANVSPTQRLRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3A7</accession>
    <name>A0A9D4T3A7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3A7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044266"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="21779" checksum="8AFD842FF1CF0DC0" modified="2023-05-03" version="1">MIIIIALAVGDLHKGSATELSIIPYRVSSRSCRANKGRAMSPQKLSSSERLLRAYVDSDELHRIELSYNEHLQHGHMLPSVQYDYGRCLVLSRFPADIIKGIVLLEQLIQLEYRPIDCCYMSALAHTKLGHYNTALQFTKTMLVKEPRNIEGSELQELIHRKVLREYLFQVAVVGGVVIMIGVLISMVMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3E3</accession>
    <name>A0A9D4T3E3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3E3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054015"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="18435" checksum="D3653DB743AEC211" modified="2023-05-03" version="1">MSPKSKMSMASRMFHGATNEGGQPKAPHAPLTEPDREFFRKLEMSDTASGLNRALKYLESKQYGLRMYAVAVEEAKHIHEDLPPDQRTGRVRQVYHRVKAEYEKEKEEREKAQARAKAHPDDAGSAAQIAAAEERLKNINLLLLYYASGLKHIYEEHDTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4R3</accession>
    <name>A0A9D4T4R3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_023938</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4R3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031697"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="40"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="262"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7970049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="444" mass="50099" checksum="3973285733EE72E8" modified="2023-05-03" version="1">MAASMDTPVDSPKRKADSQIPAEESDLLLIRPLGAGQEVGRSCIMLEFKGKRIMLDCGIHPGMSGLDALPYVDLIEADEIDLLLVSHFHLDHCGALPWFLQKTTFKGRCFMTHATKAIYRWLLADYIKVSNIGTEQMLYSEADLESSMEKIETINFHEEKDVNGIRFWCYNAGHVLGAAMFMIEIAGVKVLYTGDFSRQEDRHLMAAEIPNIHPDVLIIESTYGTHIHEKREEREARFTGLVHDIVNRGGRCLIPVFALGRAQELLLILDEYWSNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNERIRRQITINNPFVFKHISNLKSIEHFEDIGPCVVMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKTILSEPEEITTMVGQKLPLKMSVDYISFSAHTDYQQTSDWAPFLRFSCSSRPTLATVFAGCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5Y9</accession>
    <name>A0A9D4T5Y9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5Y9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047615"/>
    <dbReference type="OMA" id="SSPYMEM"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="314" mass="36870" checksum="61B6A5966DB5BBFA" modified="2023-05-03" version="1">MEVGELRFIDGLCIRSFFPEKLIKSAMAYSPRPDDVFVVSCPMCGTTWTPYLILSILTDGEPPTNFDDFMLSSPYMEMMFAEAAEKMPRPGLLKTHLPFEKHPYSQQAKYIYVARNPDDVCVSYYYFLKSMTSKRVKDVSFAKFHQLFASGSVSYGDYFHRLLSWYKHRHDENVLFLTYEQMNKEPEYWTLKIADFLDGDCVDRLREDPVLLKKVLDATMLQKMKEVFNGKMFTVIQRLLNLPPHRAIKSMEIYRSKLAHREPTHEDHGFVRKGVVGDWKTHFTKDQIKKTKAWIARKTVDSDVMQLWQDLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T748</accession>
    <name>A0A9D4T748_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T748"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035316"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14428" checksum="992B3732CDB57763" modified="2023-05-03" version="1">MKECASSGVHPTYNEARRRGLKLSSARLDKDRACFVDVASYAQEAFCSVFVGCDSKVIIALALTDGVHDTIYSDSQAAIKAFQMGMVVPQVLQIIQKAKDLKNHSLVWFPAHLGTIEGASLNPNEEAHLHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8F5</accession>
    <name>A0A9D4T8F5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8F5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055124"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49817" checksum="F030BA3492A54E1A" modified="2023-05-03" version="1">MTHAALFDRLFSNQQTALATRRVFLLRNEYVPSRVARKSSARKVPTGRLTACRSSAAALHCRSGKHESYAGRSHRAPCGIFRLIEVIRWHRLISDVMSKSRASHCGDEQRAPNMRLTSILRGCTYLLRIPIACPAALPRIKIPGASRVELDGYTDHNGRLLLEMTQELSLEIANLRADCEGTYTWCARGLSSCIDYALVSPGLGKSLRNVHIDEEGRHSLGSDHNRLRLQFEASPWRQKVKKHEPATRFLPDAAYEEVANEFELCPGREQADTYEQYIAQLRQIMRKHEKIVKARRGFSRKSWWDGEVQAAIKARRTANRCHRQCVKRPHSADVQASWQEYLRRKREMQAITQRKIAEANHKTLHAIKSAGRGAAAKFWTYVSRLDGKATQPEIRTESSGDKTTDLHRALTDHLHQLCLRTDWHRPPEVDSGKERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9W5</accession>
    <name>A0A9D4T9W5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9W5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051994"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="14786" checksum="65BF45318384F4AC" modified="2023-05-03" version="1">MDLIDAKEAARDPVPEDGVNTKPPETQEKSKDIVNNKEPDPMELKPDKKADSVSDLNVAPPSTTTCDAKEAVDVEMAIAASTSAKRSRDTGQDDVGNTKEMGIDKPPAKTFPLRRGSLKFKPTIPPDRKPPPANLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA46</accession>
    <name>A0A9D4TA46_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA46"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18029" checksum="302EB6BDEFFBB85B" modified="2023-05-03" version="1">MAWDRVTPTTIANCFAKCGFFRSSEEVPSEQEEPIEGWELLDAGCTAEDFCTADDNLATCGARTVEDIVEEATCEVADSSDDGDNIDEGDGEGPPPAAETLHALDVLRRAMAADEISDDTRVCCCCALSTDACPSPAVGCAPPGIVISAQLSTLETQDSERLFVVLSELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB05</accession>
    <name>A0A9D4TB05_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB05"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050037"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039390074" description="SRCR domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16417" checksum="D536122193A6F73B" modified="2023-05-03" version="1">MKHRPAWASAVLLCWLMHGFSLGGGRPVEIRDRLVFDLSGSPHQVNRDIIVEDSGELVIQPGVELRFAPGVGIVVNGVLKAQGTADRPVTMTVINENEPRREPHSVVHRDTGVEWPSVRLTDGPGPLRGRLQLRHGAHWWSVCTRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE68</accession>
    <name>A0A9D4TE68_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000213">
        <property type="protein sequence ID" value="KAH7986975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE68"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055456"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="71" mass="8320" checksum="5D15BB6678DF3867" modified="2023-05-03" version="1">MTKQGDERDENSPGSPPQGRHQSREEIHTVTNEVDVILSQQKLSRKRPRRLATTCLTARLRKPRRFRPRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YMU5</accession>
    <name>A0A9D4YMU5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YMU5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="131" mass="14374" checksum="7E38F1ED33A68B13" modified="2023-05-03" version="1">MPSLQSKRAAYELPDGAEFLVGGFRTSFTCPAKNGYFADVDNNCQIFHVCNVVTHADGNTEVQQYSFLCGNQTVFNQLSLTCAFAEEAVPCQNAPDFFYVNDNIGVETAPFLTDNDVQRAAQLIPSYKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPI6</accession>
    <name>A0A9D4YPI6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPI6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="287" mass="31415" checksum="599F2F9C3BD64A5B" modified="2023-05-03" version="1">MLERQLQSEAEKLVELLTVCENEMDDTNTSDLRNLAYIEYEAKDLLRLIRWMMHGLEEERLGVKNPCEPMIYDSFTREHSLGFERNELMQRGLPVTSGFRRGTITPPVQLPSENCSSSEVIIEHESPASSSMPEHRPGNGSGTSLDFTSERTTSGAFSSIDNLDSIPGPSGMSKAGHDKWPKDSSAGNMGSPKQLTDGNGVSRMAYHTRSDGDTVKALKSFATAFAVTSSKYGLPPEYAEKIAYIIHILQGDDDDGKEEANLGGKPAGSDLFNQLSSDLDSSLNDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQA1</accession>
    <name>A0A9D4YQA1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQA1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="13036" checksum="BD933881BF0A448F" modified="2023-05-03" version="1">MTIPLSAATCFIRGTLTQPLVTWPPTAFFALSCCRVTKLVRKATNSRMSEASTRGHKFTSQSAACSVNGSTPDSWIFSLYRSRSFGESVDAYIMDFADFLPHARFQARSIYDFNMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQD0</accession>
    <name>A0A9D4YQD0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein argonaute N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQD0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042522"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein argonaute N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="229" mass="25192" checksum="570646A45E98C86C" modified="2023-05-03" version="1">MSKVAVMRPRMAAGCTASGPRTARVGRSPVVLGGSGSKRLAVVIGHEDFSYRCRLLLLRPLCTTSNQANRAIVTHLLGTVNGTGPRSVNTTEGSLQASSSPPFTGGVARGHSNGICGRVKTRLDRSIRLTVNSFVETPAGNVYHCDIEIFGSRKEAKAPEKRKYICISTNINWLVIELLVKKYRTDLGVPASDGAKNLYTRRELKFRERKFAVYSEENQRRPLQNSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P9N9</accession>
    <name>A0A9D4P9N9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_000487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P9N9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027965"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7934790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="493" mass="53862" checksum="3BD8C383566852FC" modified="2023-05-03" version="1">MALAFSSSDQAAIDRTVDLSTDDVKPAADDSELEFKYEVKRSVAWICENGFRKVALQFPDEMLVDSVSVTLALQASVPAELFILGDTSYGSCCVDEVAAEHVGADAIVHYGHSCLSVPSRLPVLFIFGRLPCTTEGLEQGLHNVFPDPDARIAVLFDTQYDHCKCDVFAKISALFRNAVCSELVIPSVQQDVKNCSRGTHVITKCSRTFCIPENTSLEDHSILFIGPENRTLTNIVFTFNNCACYSYDPKTRETRRESLTVNRQLMRRYYLIEKAKDASIVGILAGTLGVQNYLSAIGHLKKLIRNAGKKPYTLVTGKLNVAKLANFQEIDVYVLVACPENTLLDSKEFFRPIVTPFELELALNPSRQWSQTFSASFSDILPGKCGELYLELEEQSSQPEYDVSLVTGKIRSLGVEGKADDEGSTTGGTLVAKEGTVAVPQLHIAAAGEYLMNRTWQGLETRLGQTPAATISKGQVGLAAGYVGEGEGGHAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAW4</accession>
    <name>A0A9D4PAW4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAW4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="12963" checksum="EF40FF3C2369255C" modified="2023-05-03" version="1">MQGWSACSENSLRSSRDARRTRDHSPGHAQCWAEQLTVETPRRDPRCSRQGTEQQARPRSEMQYSRWQRRLRWWLAGTSTDGRVPWLEPGSPASDASARCLASAAASARPQPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBD5</accession>
    <name>A0A9D4PBD5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBD5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053913"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF28">
        <property type="entry name" value="GH04176P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="305" mass="33435" checksum="8462C67AE8FA2BFD" modified="2023-05-03" version="1">MGYEIPLSRDEPEEPKKATADGDAAAEADLPDDAPQPRLCHMTKWRDFEGYGFNLHAEKDRRGQYVGKIDEGSPAEHAGLREGDRIVEVNGVNVQQEAHRDIVERIRAVPDETRLLVLTAEGEQWYRDRDIQVHGNQANVLRLRNPELNPATSGGDGTMAAAADGSECSQEDEAAQSAPTPVLRRQSGLEGKEDTEEEESRSSEPEPVPAKTEVSAREEPNGTGDKATENLVTGTSQVDSSSEAKPAPATEPTPSEPANATSNGSLNMLNMSASEMRQLLAQRKKHDPKKIQMDLKKKYELIEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBQ5</accession>
    <name>A0A9D4PBQ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBQ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044084"/>
    <dbReference type="OMA" id="AILQCML"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7934926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19832" checksum="81D481BDAE5FAA30" modified="2023-05-03" version="1">MTRYDPKERFRYLKELVTEFHTSGSNEAKEQVLANLANFAYDPINYDHLKRLNIVNLFMDQLDSANDNLREFAIGGICNLTSDQDFRTEVLKPENLGKLISCLSTSQEETVLSAITTLISLGLSGCQSDITTASVIDCMVRYSESPNTRLSNLAKLFLEDICSPEQINSVANAASAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC31</accession>
    <name>A0A9D4PC31_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC31"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042362"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7936009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25096" checksum="EEC0FCE283A63B02" modified="2023-05-03" version="1">MCRIFGNQSASPYPVLPTSLEAEEYNMSHRRRGKCVIFNNRQDYSDDDCFVCCFLTHGETDVLYGTDGKFPVSAVMEPFHGDVCPSLLGKPKLFFIQACRGDRLDSGAQAVLDTADSPNRIYRIPTQADILAAYSTVPGFYSWRNTMQGSWFIQALCSVLQDRAHFADVLSMLTVVCRRVSLDYESYTPNDLHMHRKKQVPFITSTLTRLVYFRAKPGAAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC82</accession>
    <name>A0A9D4PC82_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC82"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052992"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="462" mass="50469" checksum="9AB1DE9B3B9ABD84" modified="2023-05-03" version="1">MLMLLPGRHDEQAVTDQPRQILQRVYGTSAASGASATSGVCGRMTSECGVLGVYLSSWDHVMGPQLVFRWRMQCPGAVAGVGIPEPAECGPHFLKCHQFLENPEGFLARGEAPQQASRREEEYDVHAASVLQLLHGGLERRGTRSCLLLLPDKRAALHAVTFDLSAGAPVCLAALFPMKALADLWLLLPLTDLTLARVALVCQTPGRELMKSLSSATSLLHRYFQLASSLLSTRTLDRRASVNALSRADRLPEELIRRALQSHLQTRRCSIVIGDSVAQVEPALNALRGLLDHEELFCSLWGDTLEPCYLPGLQLQGLVRGSTGSPLSARELIWSPHPSTVVDMAQGRVWQCPLHVGYQGPLTRKLKAARTPSAESHVSQFVQQLGRAPTTAAAEQLLQAFQRHLRVKAAALIQCASRSRRALSAKYLQSVLAVPYLSDFLVILAEAEKLRPGLSRYVLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD01</accession>
    <name>A0A9D4PD01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_005745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026484"/>
    <dbReference type="OMA" id="WRIQIFA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="43"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7935320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="531" mass="57935" checksum="629D0340E98DECD0" modified="2023-05-03" version="1">MTSSDRMASTGAPLGLRLLQLTFRKCCDSITAERRLAYYRGFVLVATFLAYTCYHMTRRPLSIVKSVLHQDCRYATPDASIVVTENNSQTWCNWAPFNGDDAPRLFSYLDSIYLFTYAACMFVSGFVAERMHLRYFLGLGMLLSALTTHIFGMGYSLGIHSFAFYFVVQLLGGAFQSTGWPSVVTCVGNWFGKKKRGLIFGVWNAHTSVGNILGAYIAGAFVNRDWGLSFVVPAAICGLVGVFVVLFLTPYPEEVGCDTPRRSSASLQTSLSSAVVRPEDVPSDDGEDENYASGTLNEDEQRYLLERRLKKESEKKAVTFVQALAIPGVLDFSLALFFAKLVSYTFLFWLPFYIHASTTFSSSSSAFISTAFDFGGIVGGILAGYLSDRSGASAITCVVFLMAAVPMMFVFEHYGSVSLTMNLVLQSLAGLLINGPYALITTAVSAELGTHPTVTGSAKALATVTAIIDGTGSIGAAVGPLIAGLVLQYGWNTVFYMVMVSDVLAVLCLLRVTKYEFLRLRSRKTTRMSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDY9</accession>
    <name>A0A9D4PDY9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDY9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036524"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="406" mass="43281" checksum="C934D583348CDC8C" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLRHHILLHALPAELRHLSAASSSSPQPYDDICAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGPQPSHDHDLPSPATTPPTSRQATSASIPAPDHPPDEVQELPAATGHSTESSVFSTGSADGPSDVPAICTSSPTSMAHDTSATSGSTTATSPHALESAIDKDIVTPAIRPPIAEASPAMMSDEAVLPSTSTLCASCQQRSASPSQSLAAEVPAPNHRWPNFRDAATMTDSPEDDVPGQHTPELTAYATPATEADIQHAYLRTSLVSRPPQGLPQAQERDVLLHKTRRECFVPATTGDFSQVRRRLLIKVGLSNAVADVSSPASLLSWSRESLRSSRNSFPDTNSSVSALSTPEVHRLKVFDPTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEE5</accession>
    <name>A0A9D4PEE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEE5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="9824" checksum="DA99AC1151FD2B71" modified="2023-05-03" version="1">MPAGVGGGRNSRSRETEAARGGTLFQSLRPSGPGAHKADGGRPQRSVKKARRDAAGRLRSRTSGSEHEEATSKQRPSQRPAADDMDTDSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH98</accession>
    <name>A0A9D4PH98_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH98"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="10930" checksum="8547E89185B9CA5B" modified="2023-05-03" version="1">MWKLQGTENTHPLRVEVSVNGISLLMELDTGASVSAVLEDTFHRKFQFAQPELSNVLLKSYSGKLTLSKEAWPCPCSLAATSATTCYTSSLTAAHPSWGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIL5</accession>
    <name>A0A9D4PIL5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIL5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056499"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="819" mass="86223" checksum="A816C8C70F74A255" modified="2023-05-03" version="1">MDNTDEAHFEFEFTVDNRLQFLDLEISAGSEHTCWMYKTRSGPSGIAAPKTSTSCNSSRSGSPHTGSFIPQPKSTVVTRDRTANSDRSRPSSTASSSSISHLPVKNAGVPVRQQPPAQSNGPGNGHLIPKGSHIASSAHHNGVANHNATNHHASNGTSNNNSMLDKFKFFNSKDKSQDKSKVPKRPSSGGGFSSARSERSDSSVSLCGDAGSPNGSASGSEAAGQAKTSDSAVVFNGGSSNGPSGCHIGERRRALTTGPVVIQRAVPHRLPRVWPKRLSAGQPANSSSLGRPLAKVSTSHAGSSETVRSGLPRSSPSSETLNRTATRRSNASGSGHPRPLSSGHEIASSHVIPEKFPSPKAHESKPVPNGTSAPEDKKHQEMEINSAAQTNNVGSGIPKPTAAPEKVKNEIKQNGSVPTSPAGDEIAAQKKHDVVDVGEASKNPPLADDGDCQKQQEQITTTTAPSSSDGSGGVRTETLPKSDRSKKTQAQSVSIAMVSPIMSSQHSFSKDSVTASSTESSLSTVISVKEDKASSVIAATTNQTQQIQDNREGNQDVLVNGGLSRTGHHPENNVPQQGVAGGQTGPAVHVGDQVQVNVNGESTGTNNGLVGGVESTVKSVPAETKLVPRANSVDSSCGKEGEEMEEALANIPPMQPLPRASPYGSGYSRGLSGHRAARLPACLRLQADVQRVAKNMLAASQDIARLYGAQRPTASVALHHPAYHHQQQQQLQQQQHADYAELSAGYVSDGDVLRAPRACSTEESSGYVSEGGIASLYAVTSPCRRPARYAIRDPKLINVLQDDRWGPFYSFSLIWKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIU9</accession>
    <name>A0A9D4PIU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039083"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7943996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="316" mass="34471" checksum="770CC27EF58050E1" modified="2023-05-03" version="1">MATVYLITGVGALATYFSNDFYIFLVTRFIQGGALLSICNIPFVLALEYMPAKKRMFMLGAFRFVYPLVGAAMPWVAYALGHWRLLNAVIMLPCVVGVIVSPFMPESTRWLLSKGRTDKAKKVLLRISRVNGMHVQRNALDSLQAPEKGDNATASTAAIFKYPSLRRSFVITLFLRLLQCLSHQAGQLYAAAATDDPFVMTSITNVVDVLGIWLAVPMGDKCGRRFTMALTCALAGLCYLVGAGLYTNSVAIFASLMVGRAVQTIAYNVACMHAAEIYPTEIRTQGLSIRHAFGSLGKFLSSNVVQLVSILMVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJM2</accession>
    <name>A0A9D4PJM2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJM2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036977"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="76" mass="8502" checksum="05CE59E685E4B80E" modified="2023-05-03" version="1">MCVFAEDRESTTPDPKACPGWEVWQDCSGNDCRELSCEDPISGGECKDCTSGCYCGEGYFRNYNGGCVNWDHCQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJT4</accession>
    <name>A0A9D4PJT4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJT4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15276" checksum="16FDEBF9BA4B031B" modified="2023-05-03" version="1">MDQTAFTVVSYKKKRAAGVPVIFKPTQPDRNFWKVNPNLLASAVVTTAQEKVLSHRLNKDGSLMVTTSSVPAANRLLAVTDLAGIAVEARVPFSYSATYGRIQDVPVEYSDDDLKEYLSEQGVISAKRQVAYIPTKMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJX5</accession>
    <name>A0A9D4PJX5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJX5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056632"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17540" checksum="FD68A2435014AC94" modified="2023-05-03" version="1">MRRWRRQRHNNRLRRRIARLERELEAHTAALERQQWGQICNSLNGQMGCKKTWHLLRHMLDPGSSKSAARKQFARIIHQYPGTDEELLDEPITRYFNASHKQSSTAQLPQYTGTPNEQLDADISEAEVCVALHKLRTTSAPGPDGVTNKTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK54</accession>
    <name>A0A9D4PK54_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK54"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="205" mass="22474" checksum="C574A60EBBCF8E94" modified="2023-05-03" version="1">MLDLRTVEQRRKGLHKRVSRVDLPFPMVYEGFDVDAPRPAIRAAWSARAGRGSRSTVDATLSWYVHATPVHRRPEDEREITVDEREITGDERQNIAEDMATDNAGGVRAIHLEDASSSTTGTRRGRKRCICGRLPPCTSSSHGAPDNVDAGSSASKMSTSTLTSSAPPVGPSFPLAPMEVSSQMLYEEGSDDEERARYLADGMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKM0</accession>
    <name>A0A9D4PKM0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_021366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKM0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054121"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF2">
        <property type="entry name" value="PROVISIONAL ORTHOLOG OF THAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="194" mass="21920" checksum="C9C9D20D1F4BC5F2" modified="2023-05-03" version="1">MGLTSWFPRSKPRIFQKWLANLKRDKWKPSLGSRLCSDHFAESCFDRSGARTRLRGDAVPTLFSFPDDSQKKGLQRKAPKQRGQILELTPEDEPPMSPAAPLPEASDKVPDHDYAVLDNPKVLKKRLEKCTDAIESIKKKLKLSEQRERRLKNKVTSLSKIVDDLKSKLLASNDACAMLEKCFSGVPQKLCSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLC6</accession>
    <name>A0A9D4PLC6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_011742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039676258" evidence="7">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="385" mass="41359" checksum="ED6FF6AF815CB5B9" modified="2023-05-03" version="1">MFAQLLVIVVALLTTPDLASGSGQRPIYNIYHMTNAIWQVDEGMELGANAIESDVTFDKDGTALWFYHGVPCDCFRWCQRYEEVPALLRYLRRTTDGGIYEKSLALLFLDLKTSSVDSDKKYDAGVDIAKKLMDHLWLGAGHSPAGPAPKGLSRHGLTEETTGADYTRRRPQIDDDGAGQGISSPGVIPRTWHISKVRAETFPWERSARPAPKGSMRTFSPSPFYGGAATSGKGVCVCAGCWKNAATVISPIEQLILPHVRDLPVGGGAVAITLCLDPAGHSPAGPAPKGLSRHGLTEETTGADYTRRRPQIDDDGAGQGINSPGVIPRTWHISKVRAETFPWERSARPAPKGSMRTFSPSPFYGGAATSGKGVCVCAVIPNLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLX7</accession>
    <name>A0A9D4PLX7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLX7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="374" mass="40206" checksum="6123CA87FB51DBF2" modified="2023-05-03" version="1">MPHQVTQKAKKGNKCGAFSFTFCGVPKHEFYFDGSQGACLSVADLKGAALCNRGANKFTSLASCDAACGSNANTVEPKCDENALFTECKSIPAEAGESLWTLFVAGCFLVTVCVVGAIVFYIVLLSRSLGDAFLCTTSLGLVSIAVPPDGVCDYMFFDSLYTNNTFKLIDKAPTGELKTYLTAANSSQRTVHGVGINVRYTHDVRMHLKTREADSKNFLEALLSNKIVGFGVLSISKNQFSHAVFDTAIAALSGCDGVDQKALARNVTSPFAPLTGLEGAQIDNVVTNKYLVFDNADSLVRKYCKGTLDLPGTKFGLAAYDVNYDSGVSTAGVCEPTFTKIGNFVRVNVMRKMRDAFRNVIFRSVDDCVNAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMB1</accession>
    <name>A0A9D4PMB1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division cycle 40 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PRP17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_010061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMB1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029950"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7947319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="587" mass="66854" checksum="7B7799A5EC19104C" modified="2023-05-03" version="1">MAAMLSICEYASSDDDDDATKNEEPKENFTKLPHTTQSVVAIQKKYQLNAAPDVAIKESVCGVKPIDPTSKELLFNPKFENLFAPVVGPENPFKSQQQKAVKNTLAGYVEPAHVNDFHFESQRLTFNSYGYAIDPTADGSMDEGHRMVGTSEGASSSSSLTVFEKTKARPGDKRKKAKNNDPSDIDGFAGPWAPYKDERRNVKPSEEEQEELDEILAKRNKKGRRTEDKPMEEKTVLHIKDPYDYQGRSFLHVPQDVGVNLRASEPPDKCFLPKRLIHTWSGHSKGLSAIRWFPRSAHLLLSCSMDCKVKLWEVYNERRCVRTYNGHRQAVRDIAFDNKGERFLSAGYDRYNCQTSVSDTHLHIFISRTYTGNCIARFTNRKVAYCVKFNPDNDKQNLFVAGTSDKKIVCWDVRTKEIVQEYDRHLGAVNTITFVDDNRRFVSTSDDKSMRVWEWDIPVDMKYIADPSMHSMPAVTLSPNGKWLACQSMDNKIMIFSALNRFKLNRKKTFEGHMVAGYACSLDFSPDMSYLISGDADGKLYVWDWKTTKLYTKFKAHDAVCISALWHPHETSKVATAGWDGTIKFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP58</accession>
    <name>A0A9D4PP58_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP58"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031109"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="277" mass="31798" checksum="A92DDE3DCD5E7B4E" modified="2023-05-03" version="1">MEFVAFYDRLPLRRYNGFCSEKLLINTRSHKIINRSWTSWQSRIGYCPQRDALLGKLNAYENLYLFGRLRGVPEESLPDVVAQLIDVTDLKEHAAKRCDYYSGGNKRKLSIAIALVGLPGVVFLDEPYAGVDVLARTRIYIRLTGIKEQTKCSMVLTSHSASVHLNQYSSPINKQVYDTENRKTAGDDPVTVVEERLGDDWLEHLDQVALMDHSTQERELRYVKCALEDPEKTWFESHVAALKSWHEFRRQFLNASAIADRKGRAECAMEARVQSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPD8</accession>
    <name>A0A9D4PPD8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPD8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036813"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16718" checksum="D8EB6F25CC13220C" modified="2023-05-03" version="1">MEPGSGARSSSGLGDDDWHLEDVEEEMNHSLQDKRNLGNGVSIPQERWQHLMAQPKDSLFVREAAKAIWGVHNLYNSSITGTPCRRFLHKEGGLPSIEKQALTPRKLDALKNAYEEHLKVHQSALPEVQRRRNLNRHLADLLKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPL1</accession>
    <name>A0A9D4PPL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046517"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="461" mass="50673" checksum="AF645D7E03C1373E" modified="2023-05-03" version="1">MLANAWHNRSACTIRSGNGSEKRGDRRSPRKLFGPWGSGRDAAVRVCAERTHDQPAEDGGSAERSFDYDVDDLDQVESFIWDSSDAPHMGPTRPGPPNPPPAENLIGNDPNLHHQISEIVRQIIAEYSHRNQLPAGIWVGGKHMGPGLQQMAFPPQNPCFPPIGLQIPIIPWKVDNISPRDTANNNNNNNNNNNRNSNNNNNNNNVANSATSNNNNNDKPQPGSLPPLPPYQKPAWRPAVPVFPIPHQPQQPHSHQTHLKNPQSQPAVKTSFSISTSHPVPLPKRDLHTPLLPWRSAAPAPAAAPADQQSTGAQTMPPPIRPPKLAAHLRFAHPPRPSIRGHASRRGQHLLSQKTGVSSLPKNLPADDVYYASQSSKLPRKVVKQGVFQPKRQPQVSQSITVVEQGKNGEWFKVPVEKVATGLGRRNYEVVELHKADDVRKVGPALGNGEESIHYIHIQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQG6</accession>
    <name>A0A9D4PQG6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQG6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="79" mass="8957" checksum="09EF59C58AD1F1EC" modified="2023-05-03" version="1">MNAPGRSVKIEPETLEHILLQCVQYSDERRILVGSYREQGLATNSVDEFLFPKAHGTIIKRAHSALLEFLVSCALFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRZ2</accession>
    <name>A0A9D4PRZ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRZ2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="14992" checksum="903CCDD58398BFB0" modified="2023-05-03" version="1">MFSRCAGDCHHGYGLESPSLEVVTMETTSSDQAMPSENVYLADMVKLWERKQSQAAASSQGQRSRAGAQQKAAASGSSLAPLYIRWAHCSSLLANSKKSSGDPAPRLARDRSGEASRSSRLKSVLPSDRTGDAIRTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSA5</accession>
    <name>A0A9D4PSA5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSA5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026908"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000004">
        <property type="entry name" value="selenocysteine insertion sequence-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="465"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7950885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="627" mass="68205" checksum="82378EF6700BF716" modified="2023-05-03" version="1">MLLSFLCAFTVVDGNTSIVPDFGQASGRNGGAVAARVNAVDQEEWQGGPASPDFSSSSEFPSLPVQDFPQRQSPSGISYSTALQQQKAPRPPAVPSGATTNRETEELASSSAAGVNTRSGMQQQGRRGGGNNSGNSPNDVNNKHHKRSNGSRKHRRGGGGGGMSDGVRRAEDAEPSARLQHHQQERRGPKRSGGGKANMPAIDGGAEKHQFEAPEKDKSELRHDTEAIVANVPRERIGSGRMPHQNGVRVNAARGRRETRHSSLLRGVLKGDGSRQHHQQGGRGGGSRKGLDSDRHVPVSEDGQHEVDKPVLRRSWNSGSPARQKDSVDEYPPLGSRGTEDSLERSPEARMTKADTKDAMVKQGDNIPKQQPQTPFREKGSKPVKPLASTNGGSAGPKHKTAISMAIADIMVPKQRQPKKLKEKENLLERSSKKPESPEINKTTRTLLTDLVFFQERLYQKDPIKARSKRRLVYGLKEVRKYLLLNKLKCIVFAPDIEEVKGAGGLDHSLRDMIEYARAHFVPTVFALRRRHLGTLAKKNVPVSCVGIFDYSAREVLFKELLELVSAARETYAKLKQGLARDDSRSGAGQVVTSEPESAGNARCEAGSTSAGVVVDDGWAYIEKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSQ2</accession>
    <name>A0A9D4PSQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pancreatic trypsin inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSQ2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42853" checksum="0FCD29B57F9B8795" modified="2023-05-03" version="1">MDQVVPFRVWRVCLCDFWKATPSINMDDSEDDSSFESTGGSPEIKEKRSFPVPTAKGVFMFVGVVLVIAVLGMAGYIFYKAEEDDSAVFQGKEIVGSETTTTKKAKKPSSTRQKRRHTQTMGPQNAPLEAQPDEDGGDSAEKADDQGVADVQDTAAANDDKDMLNDNPSCTTSHNFYKCEGNEQPEMFLSHLCLSNSDSKTCFEWRPQRFCLTSPTNRFRSSKECEESCNENKNCGMAASCECSGMYRKANYVYDMRRQRCRLIPIHECVEVDVGFADNDECLSSCGSDTPREDARCKLAALEELVRPCMWEDKVYTHYYDARSGQCQPWDESVCSSNVFRRLADCFRDCPLGVIDSSSQPGNATGKVRRIARAQQVSQHPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTB3</accession>
    <name>A0A9D4PTB3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_000894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTB3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037785"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7955450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="421" mass="47742" checksum="A79F102CFED81A89" modified="2023-05-03" version="1">MRQDVYFLSSQKTRPTLFGLPLVLPCHDGTSRQDLYRLVWTQVARLVSPLPPSESTVPNHAQDCDDSLGYEYPFTLKAVHKDGFMCAWCPWYKFCRGCPIDCDDADFNFSSLYLSIDWDPTALHLRYQASQERVYVDHPSVERTRQQKVEPISVHDCLAAFTKEEQLGDREKYYCSRCKQHQLATKKLQIYRLPPILKIVRFPFKDFDPTDYLSPVPRKAALSFRRYQQTVQQKASSPLVKRLAPELPSRSSLASPVRSRPDVAELRSTSAFSAASQAQAAAVAAVGSSPRNGAPLTNGDIDAGGGGEPQDHHKHRLHPGYSPLDLKYQMYALACHTGILGGGHYVSYACNPNNKWYCYNDSSCKEVQLDQIDSDSAYMLFYEREGINYEAYMPNTEGKVPDARDIDDEFESDFRKMCVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUT4</accession>
    <name>A0A9D4PUT4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ RNA-binding domain-containing</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_007140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SZRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039059"/>
    <dbReference type="OMA" id="VADDVCD"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="5">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7956215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18636" checksum="C09625F8907AC86B" modified="2023-05-03" version="1">MADDISEDICDDWEDMVENGVLEKKLERLKVKTNSANSNNANPPASGGGVGEVAVMPRVLLEDSVRTQYTPAVKILKRPPDASRSGGNVNGTGSEKSPNRQPVKSLQQREAEYAEARLRILGSARSEDDGQKDKSSGVSVLNHVMTDQQQVPIRQPRGPDQGSNGFQQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV47</accession>
    <name>A0A9D4PV47_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV47"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="16944" checksum="0404E9C2093FF18C" modified="2023-05-03" version="1">MRLDAILAVNGIKAQPMMHAVLLNALPAQLCHLAAESSSSPRPYDNLCAAVLACYGQTYRPLPGSREFQISPPSQGAGPTGPQPSLEKNFTSPATTPPTSRPATCASIPAPDYRPDELQEVPAAIATPLRGLVCSTASAPGPLDLPAICRCFPDHHGPRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW44</accession>
    <name>A0A9D4PW44_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW44"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="14567" checksum="DE9519667D2BF173" modified="2023-05-03" version="1">MSTGEDWMRAAETCRLDFKKFKQRSVEEKRSNVLLFACGFAKAGADAHEKRVKAHGSDVPYAQRRRYLNRRSADLLKVLKRSEVYEDVRSFLEKCEQEKLPNRDINKVQAMLLVMAHVVYTGLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW94</accession>
    <name>A0A9D4PW94_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW94"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="11889" checksum="D225B1F78F6D0838" modified="2023-05-03" version="1">MASPDRSPPSTGYTEALPPLSITDSTPATAPCTVAFAAESCAAPLAVRGDSTITDEPADLAAEYTPVLIPVEARDTAYTTVAEPAFALHASRFANTSELKRSQTVNPIMTSPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWI7</accession>
    <name>A0A9D4PWI7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWI7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056364"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="272" mass="29707" checksum="6E34C9FB1ED87F4F" modified="2023-05-03" version="1">MNPAGSWRVIFLSRPNARPKTKTAALPAGELARVRAIWKTQCRRDPGSPERGAVAEGARPCCHFPNCAAALRAKPPVDQRLSADLRLRRDTAGIAQRPTNMAIRRKKPSQPARLSDQPSAVHQYSKTHRVCKANSGNQALKNVIAASTTSTKLPRQSQDRINNPAMATSSKCSDSPTTTTRGSSELLAGVVTLHGSDENRSHNATMPQCDDGNHKTGKDVEGDGAQQEDTVCKLQNRLRDNWSKLVTDRITMMAFARSLKGHKCPAFLYCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXY1</accession>
    <name>A0A9D4PXY1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="28332" checksum="D944E80942B3301F" modified="2023-05-03" version="1">MCGGNDALDARAVTAALNHIVKEKALPSIDMGIRDENIEEDDVIEELKALREPARKPPNSVAYSGLVYVDGYIAKLITDVGCETCAMLVTANKTSSPLYHLLRQQEAYDLHYPKPELLSMLDTIVMFFEKAVKYIPRTKILETLQLTVEPYLEDSPLLDCPEDRLKSCTDGQRTLSVELEGHVLDDQVAEDCVSVAEYEDNAAAALSLLCYRTEELKASASVIHDSAVTNDVANEGTATAGSRALGDQMRHGLVAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY74</accession>
    <name>A0A9D4PY74_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-amylase</fullName>
            <ecNumber evidence="7">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_017675</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY74"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034012"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="17">
        <location>
            <begin position="511"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="18">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="163"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="644"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7957329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="730" mass="81979" checksum="FF43353DFE3A984C" modified="2023-05-03" version="1">MGDRTTIVELFEWAWPDVAQECEDFLGPFGYGAVQPVSYRIASPSGDLQEFADMVRRCNESHVRVFVDVVLNHMTSNIGSGYGYDGTEFNSEAFAYTGVYSARDFHSRADCGTASGLVEDYSNVVQLLSLGVSGFRIDGADYIWPSDLNVIYKRLKEPDEAKLEIYESEPAPYRMAETQSDNTQPDSPSDTPSDAPSDAPSDTPAVTAERTTADTETATNMRKRDTTVEQGGETVTPPHLASHFDDPFIYHEMSTLNLSWTKEYEFIGAVTNATFFKTYANALNRVRQRPLKSLRPFIMEANGAGEAAQVVYVDSHETQRGIDVTDTVGDVVTYRDRKRHVLATVLMLAQPHGVPRVMSSYALDGKFETYVPPKMLGPPFDHMFNTQPVLMRENFECYNGWICEHRWLPIRNMVHFRNWVGAAAAVNWWDDDADAVAFARLQRGFVLVNNGLSVVRGLFNTTLPAGYYCDVLSGSRRDTRTCSGHVVRVRPDGFAELSVDPAAEVPAIALHTQVMKPLMEKRRRARINNCLSELKRFLMANDGGTFEKQSSRSQRVEKADILEMTVKFLRQRQLHLESDSHEEVERTQRFHDGYRHCVFEVSRYADAMEPRLRDTLLTHLQSRLHHLSASTGGTGMQPAYADEAVSSTNGDAPDLQPGRPARLHDYGYEAGSVSDASEEESSSSDYGDVASPDAELFLRSGCQDEPRDYRLHRDEGLDHDGSNEPMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0F2</accession>
    <name>A0A9D4Q0F2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_022520</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0F2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030341"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7957723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="29543" checksum="61ADDD13F206FF93" modified="2023-05-03" version="1">MSIPQADPSKTEDRPFIGVWDPLTCVDEIPTPSCLSRIRQELSDIEDNPLPGIFVCPEDNDITRIHSIIIGPAETPYEGGFFHVFVKCPAAYPAVPPHVRLMTTDAGKVSFHPKLYACGKICLGIVGTGPGPVWTHDKGIGSVLMKIQLLLSDVITPTEAYSSVLKDKVRHDTVRVAVCDAVAACLHSNPPYPSRLARVMMKTFTESYDRYEDQIKALGELESSRNLAHMLGVSVTYLYQPLMSRLKNLGQEVKDKIQPSGGLTGPGSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0F8</accession>
    <name>A0A9D4Q0F8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0F8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18096" checksum="93CBCE2038F8210E" modified="2023-05-03" version="1">MASIKKRKNTVANYFWKAGFVTTKLAETDEDGDEECIDDAFRELSSLFLATVLPEISAHDFVEANCNVQAAVSLADEDTVAAVAATQDAQADSSSGDEDHPDEEAATHAYSAAEVVAAFGLICRCCGDMEGTELLHLDSLDKIEASVFNFISKMKKQAKISVFFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0Q9</accession>
    <name>A0A9D4Q0Q9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylosome subunit pICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_015759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pICln (TC 1.A.47) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0Q9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027389"/>
    <dbReference type="OMA" id="YFMLDHK"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003521">
        <property type="entry name" value="ICln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01348">
        <property type="entry name" value="ICLNCHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7962375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21818" checksum="9BDC30FE95D32B06" modified="2023-05-03" version="1">MVILTSFPPPDEGIRHREEATAAFIQSRDLGKGTLYIAESRVSWVGQDSSGFSLEYPSVALHALSRDLRAFPEECLYLMIDGDLGEGEEESSENGQDDEQPASEIRFVPDDKSHLEAMYKAMSECQALHPDPADVGDSDDDGVYEDADEEDEGAEYDVRAAEQQRGCHQLEADAGNGDWEAGDEPMETGQFEDAEPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1A1</accession>
    <name>A0A9D4Q1A1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Perilipin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1A1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056460"/>
    <dbReference type="OMA" id="WKEKQAG"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7962659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45313" checksum="1394C27038F7ECC2" modified="2023-05-03" version="1">MPEAITEAPPRQGVQSNFVNRLSELPAVTSLWETAAQSYARAKANPGLLAYAIGTAEKSAAMALATSKPVVDKFATPISIVDGLACKGLDKLEEVYPDVKKKAHDQIVTDAVQYGLKKYDDVKDYGMSKINDIKSVSAGTVHMVAHPVETISQCQSQILGYAKQALAATEATLDQHIASLGIDMKKEGNETVPPEEVALLTRLDSISRKASTCASRHAALQLSVLQRYAGDSITRFQVALQLIQTMKQNLAASTNQSFQETLARMSLQSSWLQGLLSEPTDEAQEKNVQAMVLAVARSALGTATRALEQPAVLVRGMSSQLQESYSRLLNSTSDMLQTLTGVSNISELTAVTLNNLHLQSIRLEYSIRLFTHQALEWLTALPVVERLLPTPTEMTSFGSDSTRTVESSEEESSADESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1D5</accession>
    <name>A0A9D4Q1D5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1D5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043137"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7962704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="144" mass="16014" checksum="59BC3C4407942670" modified="2023-05-03" version="1">MKFGRLEDTHSLLALTCSALIKMAPGNRDIYFAHTSWFTYKSMLRIQKMYKFPWHTAAQSNLRVARSRSELGDTLSADQQQSLWQEIATTLNSMGPATKHAAGYRRFWNDLVAQFKGNAGVVSDATPATAANPPDQCLCCGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q256</accession>
    <name>A0A9D4Q256_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q256"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042171"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="305" mass="35065" checksum="E4E2027802A21722" modified="2023-05-03" version="1">MLKTTLAMTEDDLMPEVRQAMWGMRCSGTLCDGLVKMDDGGEFTVHKAIMASCSEYFRALFGCSKSKAARSDVLVPGVLKQTMAIIMEFAHKRIAWVRCDNVESLLAAADYLCVMAIIKHCCDFIVSIMTPENCISIHNIAKLYNCSDLSTTAYNYLMQNFIEVSERSEEVLHLEVDEVEAMMLDENLNVIKEETVWKAVIRWIDFDRDNRKQYISRLFKCVRTGLVDTDFFVEKVKARKYVAEDEACKTLRFVYDLDIMVNHEELPTPLFARQRIPYEMMFVMGGWMGAEPTAFVETYETKADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q286</accession>
    <name>A0A9D4Q286_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q286"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039019483" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="13400" checksum="85D418A83BD4D41A" modified="2023-05-03" version="1">MMTLNIIIIMKLLSSAEGLAFTAGLDLLFNFKAIVVVGVAIYLLTLPSRLEDSADGRPGGDVNSGGCASGDPGKCFGFRRELLDSMDLSRDPCEDFYGHVCGLWPASHPGYRDQLHYLEATQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q409</accession>
    <name>A0A9D4Q409_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q409"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31388" checksum="4F5E3FBEF8B0B23E" modified="2023-05-03" version="1">MEIVEVEGTSISPEECTVESGWLVSHKYKQRQQQPTQVDQATSMLKKSALPHPCVRARAPRPPKLPEDDIKVVMRFRDGFNTAMVGEAQIRDAILAVTGLTPEQTDADTYRTNPASNIVLVSTPSMENAERYCKTTHLQIDEHKFSAAAYSTSPDNTVKGVTHNVPSYDTAEVITSSLVNKRNPTIIQARRMGSMDWVLIVFDGYQVPYQVYYRGAEYKCYLHKNKAEFCTACGLVGHRVDVCPSPPRNRCATCYRKDLQPDHTCQLGCALCGLGHSTGDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q479</accession>
    <name>A0A9D4Q479_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q479"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11101" checksum="A5D3F6565D340CFB" modified="2023-05-03" version="1">MASLPGSASNISNAEIAKSGVFTQHKTRDMDLDKLTAVAAQLGLSGAELREWIEREQVRQRDERAAEREEAKEAAERQQLADERQLQILQLKLKLQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q483</accession>
    <name>A0A9D4Q483_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q483"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036627"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="28900" checksum="B25253D1FB201674" modified="2023-05-03" version="1">MCQEQSSAVQFRAVEKASTCEGSSRFKNEPRLEAAKDAALIGEAAEDHSQRDEVLCQWNTTETTNRVAENLAQTPSECVAALDFACGVQGDFDPLGKNTRVRSLDGARVESREYNAVVDSSQICELSWSEESSCIVPKRFRLSASLPSKEDDDLFVSHLDCVGETTDEGFEKVDEHQMRAGCSKGGKEHYACKERLETLEQCSRSEAFVIFDKIVFHASAPPDEKKKKGGLCANAAQWEGVGSPAVLSAARLMGHGSAESVDPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5A7</accession>
    <name>A0A9D4Q5A7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5A7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047540"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49915" checksum="3D720EBDB51243AB" modified="2023-05-03" version="1">MAAVLQATVQAAVREAINGIAQLQSQQTAAMPVIGAGETSRLVPLFDPTSSDSSTVDAWIRRVDDLAEVYRWTDRVTSCHALAKLHGPAKMWYYSLLSVNKTWPEWKVELKRAFPTTAGMQRLYREMEDRIYKRGEPIECYYYDKLAKGRRCNLSEEACIEYLITGLNNQHTIRAISTRTYDSPEELLCCLKRLEERVAAVGSREIKHSKASELRNLAGHGNNENRAAETALNDSQQNQHNSEPRRETEPSGPRRKTPPSKKGGLRCFNCNKYVHSGGRGAAFVTEVDTKVNGSELRAYVHLSSQCVTIRRQDADRIGIKYSLIGKPLTIGDYGSGRVTPCGEANVNLTVDQATANVPVLIVPNESQAIPVIVGHPFTEQPHVTIVRRWNTVRIFEEEKNVDEGDDTLQTAKCARSCCARRGSKDGARPRPLCEPSRPVAGAVMGHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6P1</accession>
    <name>A0A9D4Q6P1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6P1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038890806" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22723" checksum="776581836528E79C" modified="2023-05-03" version="1">MTIAIANHSLCLSYIAAALQVARVAIAAIATDRKCFVGGVHFPRASPASYGGFHPHTTREGAREARTSSYMHDIGSRMAPGASERAPSQGRYQSPRTLVYRARFAALASSAHVRPPERVQATYSARSGSVRVVRALSGDEDRPDEAAATRAYFAAEVAAVFGLIRRFCGDMEGTGLSHLDSLDKIEASVFNFILKTKKQAQDKRFFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6T5</accession>
    <name>A0A9D4Q6T5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_017503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6T5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038726"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19735">
        <property type="entry name" value="bHLH-PAS_dCLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF3">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7969384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="346" mass="38521" checksum="77A13F8A6A6E3A4C" modified="2023-05-03" version="1">MKRTPEPGPTLQQQQTSQPAHSSSAHRRNEAADESDLDEKDETKRKSRNLSEKKRRDQFNMLINELCSMVSTSSRKMDKSTVLRATIAFLRAHNDVSIQNQDQESQENWKPSFLSNEEFTHLMLESLEGFLLVLSLSGQILYTSESVASLLGYLPHELHNIFILDILHESDHGTMCELLSSASSQGAGIIRQDGTQETYVSVDLYMKRGNLGSTDSNARYEPMNLKGTFLTAVGDGFPLGGLEYDSNSCSSACSPNTGSAELAAPCLVAMVRLQTPQLMHELILCDGSRNEFSSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVEDLEKVAAGQEACTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8K6</accession>
    <name>A0A9D4Q8K6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8K6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055356"/>
    <dbReference type="OMA" id="HRSNGGR"/>
    <dbReference type="OrthoDB" id="6352295at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038948">
        <property type="entry name" value="POLR1D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769">
        <property type="entry name" value="RCG42593, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769:SF1">
        <property type="entry name" value="RNA POLYMERASE I AND III SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="15025" checksum="2A299A7FE6E33C32" modified="2023-05-03" version="1">MSLTDEELERLAREEILRETKRGAERAKDHGAYGWQKPRVHPTNKNFLKNTILSTLVSRKGARREDTKRESGRRPEKARSPADSGGKSAHRQSSDDRPNKPSQDRRDERRVADDKSGRKRTHDGVRKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8P1</accession>
    <name>A0A9D4Q8P1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8P1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043033"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="40206" checksum="0D701BE8AD4AB3F4" modified="2023-05-03" version="1">MLSFLRIQIEVREEGRPGRTPSAFSRLLPEEDVEPPTAPMGHLPTASALAAESVPVTEEVCPLCSSCQHTIADCNVQLPAEEKRARLRTARCCYRCGLQTTSRVFADVRAASSVVSATDDISLSSVNCHAGSPNPCKRNDSEPRRASHRRARHEHAVSDIGSKRPERNQRRSSPNRTSLDRVRPREVIRSRRVALTLRGQRRDIVVTVEALEVPEVCAVTSPPLSTDILQLLCDKNYDAADNFHPDTWNPQEVSVLLGSDVYWKGTTERERSSASTSALFLHCSTKSVPDCDLSAMWRLDVIGIKAPAQEKSKVPPELEAFEEGIVKLDGRYQVPADVKGSRNTCRQRHSMVAERRLQAPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q956</accession>
    <name>A0A9D4Q956_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="13664" checksum="3AB10656E4E9C208" modified="2023-05-03" version="1">MAVRAWRVALSDQNQGGQKAGNVTATDVVDAEYFASVLVEASRRVGPAPRNTSTALLARRANLYYSVPRGVGLHAQAGPAFYEQALCIREHNHPCIVDGWTLDSDRIDTMALRSRGLAVPTRGAGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9F3</accession>
    <name>A0A9D4Q9F3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9F3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035133"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12184" checksum="FBB31DF06D22CEFA" modified="2023-05-03" version="1">MAAASSIHRERWSFQRNERWFEDTLPHLGEQHFRQAFRVSPTTFRYLVESCRPSLERQTTNMREAISVEKRVAVGMYRLCSSAKDTIADLFGIGSLLLELQLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QB34</accession>
    <name>A0A9D4QB34_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QB34"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025975"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="28884" checksum="53AA8FE786850034" modified="2023-05-03" version="1">MASVEWLRKNRGVVRASFTRTLTLLTHELQVSAPDVAKVESPDAYLIQKNAELVSLNKDIFDVTDDDAYEEELEVAEDYDRKLSYAAANKATATSTSRPIATLANADAGGASTSANNEAGDPSPRVTEMTPSRGTVPRHRTVVLPKLQKPTFSGALRDWQSFWDNFSATIHLNDELLQIEKFKYLISYLTGAAKRAIEGIRLIDDNYTIAIKTLTELFGRRDLLINEHVDYLLALESVKSSADVENIDCSTTKSSFWSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC40</accession>
    <name>A0A9D4QC40_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC40"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026042"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="176"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="522"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="897" mass="102928" checksum="B0A44D819701F3E2" modified="2023-05-03" version="1">MMRSMILMMSGTRRDSLVPEGFVAARRESLRPDGLPLPLLTRRSSLLPPEIALRPRRDSVRPERRDSYIPPELFLGRRVSLAPEALNRRLSLAAAVLKPAANESASPTEDITPYGSYSSFDAVVRDRILQDKKTDVDDLILASALVRDAMESYHSDFKMTEKAVRIYNIYHHWGLQLVLYIFILINHLLAVFERPAVHGCELPLWGTMLIEFICLSFYTFRLAQAASFSRAEVFWKDPKNLVVMGVVGVTLIDMVIFTAMEMGGLTGMGIRCTRPLRPFLMVNFAENKQVRRAVRNIRNTLKEIIYALILLFMSIALFSLLALKLFQRRSLFYPDGRPYFKDYFDIYFSLYVLITTANHPDVMMPAYNDNALFALFFVVYTLICLYIFMNIILAVIYYNYRENLKVEVQNMVAVKRDNLSRAFDLLKVRDGDSFVITYSRFVALLDKIPPARSEVTKKILWYVLDQNGDNKVDLPDFMYLADLLNVRIVETEETQNCFEKYMPRVYNCVVSQWIRTMTAHIFFRYLFDLLILVNAIVIGLDVYEAEWFFLTVFSVEIMLKIYAFGFVQFMKQAWNVFDFIIIGSAVVGTLYEVAVGASNNSRTLTLDILLVLRVLRLVKLIRNFKKFRGIINTITNLGPSILTFGGVLFAVYYVYAVIGMELYRDKITFYGGFNGTHSMETQLYCGNAKLKHSTFYATGYCKNNFNNIFSSFVVLFELMVVNQWHNILSFTSIKAARLYFLLFHLSCVVIVLNIFTAFVLEAFLLEYTLDKTKIESAVETKIREMGLKLGKQPRKKSSKEEGGSGDGKPQFSEMYVDSDHNVLEDSLDKPDTARNPNVPDMSDSVKSRFHIMKKRRVEDILVMMFEDELEELEIMAMAAANVSCTCPCTCGKKQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDY7</accession>
    <name>A0A9D4QDY7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046859"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF101">
        <property type="entry name" value="ZWEI IG DOMAIN PROTEIN ZIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039513317" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="358"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="454"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="550"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="646"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="744"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="839"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="936"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1130"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7976670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1326" mass="141466" checksum="22A1F7576AA59258" modified="2023-05-03" version="1">MRRLRSLFSKFVIASLAVTLTVCQAPPRIREFSFSSDLSLGDSAALTCAVKRGSAGPHTFSWLRDGVSLLPRPRVSISRPSDVMSILAFENVQPEDVANYTCVAANAQGQHSMTAALLVTAVGPQIRTFSFQEDLSLGDTTAVACALRRGSRGPHAIAWKKDTSRPLFEGIGGRVSVQRQSDALSVLAIRDIGYEDVGNYTCVASNDHGSDQHTAQLLVSGPPVLQLSSFPPDLTVGEDATFRCVVRSGRPPYKFRWLKDDQDIPATERLTTSVASERVATLNVRRVTIEDIDNYTCLVSDSEGAESAITASLVIPGDITRCRWSSMQDHHARSRSNRLAGLNSQVASGVQSVSRRPPKLREFAFPEQVSLGEEIIIGCVVRRGTAGPYNIRWLKDGSAVDESERISITARSEGSATLRIVSLRAEDVGNYTCTARNGFGSDSVTAPLVVHGPPKLRTSGFPSDLSLGEDTMATCFVKKGSDGPYTMTWHRNGQEVKDTARVKTSVKATGTTIAIDGIRVEDVANYTCKATNAEGSDALTLPLVVAGGPPELREFAFPSEVSLGEEILVGCFVKKGTAGPYRITWLKDGKDIRESERVSIAARSKTSAALRISSLRAEDVANYTCVASNDYGTDSVTAALIINDVPKIQEFKFPANLSPGDTAHVGCIVSKGSAGPFELSWWKNGVPLAHDSSRTSVTSHKGGPVSTLTIVDVSASDSGNYTCNARNAAGSDSFSAFLAVTGAPRLQSSGFPNELSLGEETVATCFVKKGSTGPYTLTWHKEGKPVRNSDRVVVTAKSTSTALSIDGVQVDDIGNYTCSAANFAGTDSLTLPLLISAPPSIRRFSFPPEIALGEEVIVVCSVKKGSSSDSYSIGWQKDGRTVAETGRVSTSSQTKGSATLLIASLEPDDVGNYTCTARNAFGSDSFTAQLVVNDAPKINEFKFPANLSPGDTVAVNCVIRKGSAGPFELSWLKDDRPFEPTASLTVTSPKGGPVSTLTIVDVSARDSGNYTCVARNFAGSDRYSAHLAVTEPPKIKEFRFPANLSPGDTVAVNCVVKKGSTGPFDLTWRKDGVPVQPTETLTVASHKGGPLSTLSIIDLAAEDSGNYTCVARNAVGSDEFAAYLAVKGPPRLLEFAFPPDVGLGDEIIVACVVRKGTAGPYRIAWHKDDVDLRENGGRVSVSYAHNRRSSTLQIASLQPEDVGNYTCSASNSFGSDSFTAPLIVNDVPQIKEFEFPANLSPGDTVATVCLVQKGSAGPYELSWWKDDRPVAPSTSLTVTSSEGGPVSTLTIADVSARDSGKLQLRGPKCGRKRSVHRVPRRYRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEV3</accession>
    <name>A0A9D4QEV3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058247"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="516" mass="57958" checksum="4FFFF74D5D878143" modified="2023-05-03" version="1">MPGEKKRVKYWNLSMDDLNTDSVDTEDTDVLELYRKGPEDYRCLDDNESERRVDETRAVALAYEKLSEKEAAILRRLLRSGRPVEELCLHDISLCAFRLAFDNLEQCPSLSSLYIHVDLQGKELGRRFSAVFTSLQSLELSCDNTGSRFVYHIASYMRQNKTLRELRLCNSCGGDEGAAVLIEALAENNTLKLFALNDIKSSSDTLVGFAKMLATNRTLEMVHLGEVRCGEVVKVWSLLAQERYAGVFQRLQVVWPDELLSLLTVLIRREVCAPTVSAGVTSSIDEGVLREFFDAVAENKTLRRLYFDSEVFDALANGIAFVVKSTRTLWEIHVTMEAQRGSEYQLITILNALKENSSITHFAMCIEMVTPEVSTSLAELLAANKALTDIYLCEESNISPTAGQTILQGLRANYTLTELGVCSKFDENNTTRDIEALLKRNFRILEQAADFVISGGDVSDQVGPYALKKVHSWLCRDVEVQNREDNGGDATRHTGSFSSRDCVISAFQNKAYFDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGG8</accession>
    <name>A0A9D4QGG8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055128"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="24930" checksum="BDA43E82CD62B802" modified="2023-05-03" version="1">MADDLPPGFPPCYSLSGDLNHSKTYELLMKEAANLVREQATQEPWRLSPPRISPVRTNRTRARQLKDAASFLRKDTMPVSRTRTRKASRTPAAPKNAPQPGKARKGKSAQQTTAAIFSPPTSSQMHPESQQRSPQNPLLEPIGSSNREECCTQHDKITFAPSQQESETNSRGSPPPQTPPTWKHTAPPSCYPADPPADSSPEETRLAGSPLPSFPPSQPPLTPWNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGR5</accession>
    <name>A0A9D4QGR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adherens-junction anchoring domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGR5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051169"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative adherens-junction anchoring" evidence="2">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14800" checksum="AC056AF48AE328A6" modified="2023-05-03" version="1">MLMMLHQSYVDFPVDTIQSSVPRPKSPHMNNEEPIELAHFPGARPPKPTEIPKIERDDFPAPPFPYTDPERRRRWSGSSKEYEVDEEEETNEEAFEEDPQLKKEEEELSKIATGIGKVSNTFSIAISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH45</accession>
    <name>A0A9D4QH45_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_002181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028804"/>
    <dbReference type="OMA" id="HHTLRTE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000009">
        <property type="entry name" value="aquaporin-4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7981955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28771" checksum="0C51B27DA62AB28C" modified="2023-05-03" version="1">MGRVRQFRSFCGIDEVSATSSLWKSMVAEYIGTAVIVLIGCGSCINWGSPEKPQGEATMVQIAIGFGITVASMVQALGHVSGGHLNPAVTIGMLFVGRVSLLRSFFYLCSQLIGGITGAAILRAVTPEARHGALGGTSLAEGVTPLMGLGVEACITFILVLTVFGVCDANRLDVQGSAPLAIGLSVTTCHVFAVRYTGAGMNVARSFGPAVMSGMFDDHWVFWLGPILGGVIAAVVYENVFQAPPITTEDLDKAQITVMAKLANKEVVADRTTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QI47</accession>
    <name>A0A9D4QI47_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QI47"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="205" mass="22523" checksum="C925C9F717A6AF1C" modified="2023-05-03" version="1">MESLPLENVRAQKRHRLRRRLMPSPVRQSSQVATGSGGLPPWEHKDNLRRRSTRKTLPCCPGGNIERDARPPSRRFPEATAIQTAPRSGGRCVLGKKIVPVGCRHAAHRIPLLQPVARMCLSEQPAEVPRDIGIRRATTAGGESSLLDWPSDTTFGTIYSADSGLLPAGSKMATFSGKQARRAGATAVHRARHEAEKQEQHDHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM38</accession>
    <name>A0A9D4SM38_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM38"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027973"/>
    <dbReference type="OMA" id="ENHGAKA"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="328" mass="37323" checksum="2600E666FB01B8A5" modified="2023-05-03" version="1">MQRDTSNSLQYGCELSPRYVCEDGDVVLVSYPGCGVHWLQQIVQLILNYGQSAQDYVEFARRTPFLGRLIAGGRRSQDSDFVVPKGPRTLKTHAQILGGGVSLSKVKYVYVARNPWDCCASLYHRVMFNRSTTSSAHVVPRSNFDEFFDLFVTGKFSFGDYFDHVRCAYEHRKKENVFFVTFEDLKADREAVVLKLGHFLGVEYGETLENCDDVFENVCEKSSFDYMKRVYGARTEQGSDSSAVASTSPPVVAEDIFVSGSDGFFKFLQDGDHFCRALRSGKVNDWKELFTLEHRDRMKARIAEKTKGSDLMSLWRLQSKYKCLAAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMG6</accession>
    <name>A0A9D4SMG6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_005723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMG6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037068"/>
    <dbReference type="OMA" id="HWDINIQ"/>
    <dbReference type="OrthoDB" id="6486147at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="562"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7935298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="86644" checksum="9ABF96103DA18908" modified="2023-05-03" version="1">MSSARGSVAARKSQGDVAFKDVDKKTDVDTTDRVEEPESDDEFSPSVLRAGVFRTSKAQWRRYSKCVVAGGMAALLVCLAIPAGIRSYVGCQSPNCENWLEEMSYSIDATKKPCDNFYDYVCGRYSSASDSFFPNAFLRLQVRIFLSFYKRIMLQDVDTLREDEGEDSPRFKAVYMTQQCLQEAMNNVDRLDTLKEFLATYNLSWPPDKERLPTSLLDTLVELSLKRDIHVLFQLQPDKDFSRPGFHLLHWDINIQGVVVWLMLRGVLIEKGELDKAFRQSALLLTGRELPPQLITRIIDLDSRFLAVTVLPLLAVRNNQTLEYVKFSDADSITLQANSTVRLLHAVNRLLPADRQLTADDRMIVKNKFILPFISEIVLGEHSGSETVAGYVAFLVALQLAPAMSGRYLESLVPSEAVSFVVRLLMCLIVPNQQLSYAMVDLFVDWFVENDKLAAIRAMSAALWKATESIITDLSWIDETTRKKGLEHIRRLGRVVGHPFNLSDAKRELREHYAFVPRLPASHADMFTTVHDAHARRRLELLKATKPSVRQEDPEQPMILVNAFYVPIYHWVFIMDGIMFAPFYTLTVPESVNYGALGHVVGHEVTHSYDPVLGVFNASGLKDDWWSPKSRELFDKRIQCLRDLYNEVPWSYGVRYGDSALSENFADCGGLEKVMRALRELGPQPGVTLGEHSFTAQQAFFVSSCFKWCAKYVPKPAAGEQPDDIAKIYSPLNMRCNVPLMNTPAFADAFGCAPGTIMSPKVRCQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMW0</accession>
    <name>A0A9D4SMW0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026790"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030986"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040451"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056080"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135850" checksum="F64B075D1A8858B4" modified="2023-05-03" version="1">MKEIVAGTEITPEEFEASEWLTQVNKSREARTSKGTTIPPASDTQDGRSTSHKTSNASNDDTAATDRSLTPRQRGRRLALNSVASKQPRLPSDALKLIVRPRGGLLLSKITNFILFEAVCTAANFPKSSVRGEDLIQVNPKQNTFAYCTPAVERAERVLRLKELVIGTHTYEISVYCAPDESQGRGVIRGVDLRLDRQGIQEELEDPRNPPIVDFRRLGNTTAVLLTFKEPRVPMWIYLCNARHRCNLYKKKFEVCYRCSELGHRADVCASTVIKCRGCAIPDPPSDHVCVPTCRLCGKQHITGDSRCKEIYRTPYIIKRRQWEALQQEEDSKQQDQATQRRVALKRSSRWDRQRSGSTQRKHRDRSASFPPLEADSSHKSSRPSSSSRAPTSATTPPGLPAGKPHGSTVPGTPSAAPPAAQTLILIMAGRSRNTTIWQWNCRGFARKRPVLQQFLASRDRPEIIALQEGGKHAQLAGYKTYTSGRANSQVATLVKRNINVIPHDIGSNFPDHVLLEILPRPSRKPGHCLFVLNVYSPPRDRRVEFGPLFLRVQQLAQHQPHIIMGDFNAPHPSWGYHYDSPKGRSLWEEWHSLHLNLLTDPAHPTRRGVGVARDTTPDLTFVGPGVNATWCNTLETFGSDHYVLEIVIQEPTRERLRSARLTDWDRFRTQRQASGTSQRITDISSWSATLLQHVADATTDIEVEKSVPSCDRHYAKLWARKRKLETLLQTRKWDKDIRRRLARVHTDIENYAIDLTRQNWNDICSQMDKAPNSKNTWQLLRHLLDPDGGKLQAKYQLERIFREYSGSSASLRQELINTYIRPGPVIPLPAYQGVGNPLLDAPITRAELILATTAAKANRAGSQLSPAVVQSEKLSVEMEPPARRFRFSIEADIFLLRKVREQDPYKAPSLWFTIAEKLSLVFGKPISARAIRERCDLLLAQFAIEDRVNLRKSGTEEQYGEKEQLLHEIFDVARSHGYRIRSGAARKAAGASACLSSSRIGRAECRVASAVRDSTAATLQAEAESGDDSTAFGQQKQRNMWSTNLRATAAVVTSPPERPSDVLGESSQSPLPQTNALQEDSTVGTRESSSAAGHGAGIGAAGFAPRARKGKKRTADRYLEFFERRFALEAETREREAAQEDRRLDIEERHLALQESQLQLDNNMHLQRVREFEEAHEERRQERAMLVQQNQLLVNVLQALVQKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMZ1</accession>
    <name>A0A9D4SMZ1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037990"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1613" mass="174236" checksum="BBB8DF279786B5A0" modified="2023-05-03" version="1">MSDAPKKAAKRLIKWRDSARRQLSTASCSDDLASALQFVLRNVAKTFRAVLLSSDDDQLSRDLNDVLCHVSSHLYLRSRSLLADRSSRFDYWAHQCAVLSYLLDLSLVRDDPGAFTKICFVLSKNKHAVWDVLVQTSAISSASDLQSKLVDLFRRFAAYCPRTCASAELYFKFVVCAACLARRLPERGWKTVKPVVPLDRARGVRLRGMVRRAAGLGRATPSVRGADVSCQRRRATPRRPPKSTVFRIADEEVPEREQDAKVAEVEDEQLQAILDATLSRLQSNFATPHASEAEPNSEVISDISNSPLNTRVFLDRLLRNSAGDTGDGELLKNAESPTKKLGSRQHESVEGVNNSAENEAVTAALAKAHEDESSDEENGVECSAPQKAVPSNSGSSVGHPAQQAKSSDKEVCVKHSATQEESSNEKGSVEDSALQEAEPSDGEGSVDHSTRQDAEFSDKCSVEHPAHPQPGQPAVFSEMADEIPCGQRSPCALSLLDMHLSPPESDKYNSLSPVIQGSHPAAESDADTLEIQSNDEGVASCRQRAPRLSQATTVSVSSQRRSPSPFSKLRERVMSFEEDSDDETDAVDFRRKKTSAALPQSPFKLPLLKKPGTSALCKSVKSKRQDGRCSSDKRNSPSKSQPARRRVRSRGSVSPQVKQVAMSNKWQVSVSDSDSADAATSDIASVSLRSSVVGSSNVSAAKAKDLSPGNKKASTRRNSPRTSLPTNKSSKLPEANKTSELERNGASGLDSDVCQEDENKPLVSGKQTRESPANVEKVVTLKTSLPNRRKDTPRPPPLTSDLALREKATLKLSSSHDSDGASVIVNKESGSSEHSRQNKDSAMQPLESVVSTRRLSARSCARRLVLGQQNEVSDSNSSSTCIDVNGRTVQSIDVASLSTGVERQDDSKNANLTPEKPCAPAKRSSGHLAHRIEASTRPGDLSDNGIEHDAPRKHPCPKSPTEMAISSMIKQKPGIEAVGASTSRTGQLASGSGYGSSPSPIRGKTPAYAVNETGQAKHGVLTRSARRQLSFAIDKTSLSKVGRTTRSSRVVGPDVESCGNSGDTTTKSRLRENIEPPPLKARRRVLQDSINDGDSVSDLLSTQGEEAITEKESENENKGVGSPSPTVTKCPAITVGRLQSNETESAATVSGSRNMPRTRSVTVSLKGREEVQVPSTTCDVSHASKQQLEGSNTGHIAGSSRSPLRTPSKRRRVAEAGANVTPPLETTERDLSQTNDGLGGLTQVPLLRNVNASSDSLSSNEEKEFVCAMRQRTQSLRRLPSRRCSQRNNEEDFVIDVDAMVRSFSDSDDGDPSYEVRETNLDASIARLRRLKVPLYALQEEQSRPQSAASSYKVASTSARRTGRLSLTAIRASQSENSASTQSSRSPRFSPAPTTSSGITDAQSPSSNFCTCQSPSRHTRSFGTGPIGAAMEKQAEQDVQSQFQSNVGAPPVHTDTATSAEKTPVLRRSTRVGTKRDTPAWPTRSNHLTSKVPAAAKGPRHPSKDLDVFTQEQTSRATKRSKNSKMSPLLKTHTEPSDESLNAAEQESVTDKASSAICSTCNRSVNSPSTQDSGTMTDDSYLHDEDAFSDSPRLELPGHLANTVQQVKMQVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPK3</accession>
    <name>A0A9D4SPK3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPK3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11465" checksum="62849185EBB15A3B" modified="2023-05-03" version="1">MSEPAVVISVELLLLDTINHHPVLYDKTNPRYKEAECKKEIWKTITQDMGVTAAREEASTMATNSSSSSELIILLQHVVDGSATMLTTYDDNRNARARSIGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPY0</accession>
    <name>A0A9D4SPY0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_008128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPY0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028748"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7939186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="345" mass="40367" checksum="7E2976443528A95A" modified="2023-05-03" version="1">MGCPHRIGSLDGPALGKEWHIGGWAVRQICSQPLDTLFFVHTAPSHWTNRVHLRATLFEEAARTAFNWTGVFFVGEHEDPLVNLWTKLEVEVMGDVVMFPYNDTYFTMLYKFVGGMRWVTEHCPKVRNIVKIDDDVGVQPFELRRYLDEKLPLKNSSIHGFVWADTDVYHDPRSKYCVPEDELAMDTYPLYCSGRSMIMTTDTMRKLFRASKVVKGYAIDDAYVSGHLALFTNIGHENMSSISWLRPRHDKTVRMLKGELIFTHEYFVYGKTIGRRVQWGLVLWVHMMEAPQRHSYDYSDRLSDKEYRDDFLMTRRALQEGWYLPSPQYYSSLLGLRRARLNQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ11</accession>
    <name>A0A9D4SQ11_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ11"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037620"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="302" mass="32618" checksum="FBF915318E929ABA" modified="2023-05-03" version="1">MNPMKDDTSSPAVGPAVPTTQGSLAEAAGAPVSSNIPPPAPRQPLPSGFDVQGAPSHPPQSSTGPSLPMANCLQALASQGEADRRALMQDFETRFATRLLSLETALAQRTSTADDVVADLAARVSVIEAQSNRQQRVSTSVEQNNIGRAQSRFFGAHLPPPTFDGTTSWAAFLVQFESVATLNGWTVQDKAHAVQLRDAAAEYLEYIPQGIRSNYEALVSPIESRFGDRHLLQLYLTQLKHVRQGRRYLQELAAHVDSLSRKALSGCPTATMDLIAANACVDAINNRNVQRFVRLARPIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSB1</accession>
    <name>A0A9D4SSB1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSB1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9562" checksum="51473636F0DC6A4E" modified="2023-05-03" version="1">MTRTHKALEIEAHRAALQAEAHREDREVEKRRDVLDAEAPREAQDAEHPAFMEHDEVEAGRLALCRTLDAADIPFLFKHPAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU68</accession>
    <name>A0A9D4SU68_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_008990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU68"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047326"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="300"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="820"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7947249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="961" mass="107413" checksum="7A2BCE0DA04B1866" modified="2023-05-03" version="1">MAHQRTPQPKKRSSNPPQTSRRSLPTPEQSPSYEGRPSHVEPVGYYSQPVGYYLPYATVTPGDQPPVRSPTPIDGTKGGTASSPAGALQSLFKPPPTPAFLGPPPFYPGPALLSAFPAVDHRYQPLDAIPQQNLNKVLLELLSRAARASDEEPKGKSRPPARPGGCCRAAFFVATLVLALMAGSLFSFYVVSGKLSEKDLSFFNLTPFAVLREKENKVAAAPKEEPSSRAMALPSTSDQAPTLAAKPESGVFYLDPKWTTVQEPTEATDKHRIKVPRCRTAFCREMTDRFKSLLNWTLSPCGDFYEFVCSSWKSHEKGAFSQDSLYAEEVEERLRDSLLESSELENQLFRPAADRQDITENSTSPLGYAETLIELCMNDNDNKSDSEKQAEQWMHLRSLLTTIGLEKWPYQNDNASRADLWTTVALIYRYLGLPTLAAVSVEKDPENETSLVISIDEPDIAIGLFGTKDVFLPNWYSHAVRGTMKMFSPYKYLSQADKVLAFSEKLAGITSTRGERNYGEETKITTVHYLPSYAQFLGLLFDDITTVHEKTRLLVKNMRYLKALRTLIHMTQNKDLLNYLGFRAILHISPLMFGEQFVELASVRMRQLTGNKKLGWPRWKTCLRMLEEAMPFVFQRAIFTATEKLLNIERVTALLNDLKSSALLAVSNFTWMEAADKIKARNILSDVNLEVFFPSWIREDNGDAFNLLLPAPPNNTAELLSAYSDFVRKKTERRLLAIAGASVSSYPEWKGSIFATYPKFDYETRSVYVPVALFNFSAPDTDAGLLFQTPRVATRVLTALIASLHRNSYPLPGPPTMPNPTETMANATACLQSQYRSLSNNLHGEKIRSVVTTTYDFLDNVAMEPAVTVFSKYVVESGVAVQQDMLNLPLSSKQLFHVLYTADMCESGSSEQLRQEFAEDAMTHPRLRVLIPFGNTPSFAQAWSCSSQDPMNPAQKCHLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVD4</accession>
    <name>A0A9D4SVD4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVD4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038111"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="28542" checksum="3B6EA7DF2CAC0C17" modified="2023-05-03" version="1">MENASALAKGDIVFSRWNAIHVPLLVYTHAWLDGASVPSSPTTETLSDCPETDVGRRSCSPLLVSASAPVHDILTSLREAETTPRPAQLEEPAPDSPSLGHIQTPAPVVLHTPTVQAPEEPKASIAVLDDEFHEGHNLGAEDTRSNISNESNAEGRAADDTGREQAFPPRISNSATLPDTTTTFAQVPAPLVSGAPFVSVPEDLVAHTTVLTDPPEPLPEHSLTKCAPHHFTLSEKVLRDKRENVALWIIPEPIEMRSSFPKNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVF1</accession>
    <name>A0A9D4SVF1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_001466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032865"/>
    <dbReference type="OMA" id="LLTDQYC"/>
    <dbReference type="OrthoDB" id="9994231at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7950782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="241" mass="27073" checksum="76E7FB8BA5B733F1" modified="2023-05-03" version="1">MPFGIKPMCATCKTTVSSMWRKNENGDVLCNSCALRGHAVPTEPEPPSAREPNGNGCPFTLRKSTRAKSSKLRQQQQQAKTAAPKGKGRRAIFKRTPLRAPTAVATCVTSDYVFFRGTYYQVGDIVALMDENDDTYYAQIRGLLQDQYCEKSAVITWLLPTSESPRDHFDPSTYILGPEEDIPRKLEYMEFVCHAPSEYFKARKSPYPVQKPPGPECGFIWTRIGPQIRPVPTQEEVFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVQ7</accession>
    <name>A0A9D4SVQ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVQ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19450" checksum="0F56A87EB7FB0C30" modified="2023-05-03" version="1">MEKFFLRALGRSYTYCCAEATPPLPAPQQQQPPPPSGRTSGGGRRSTDVAVLRSKASARHARSSPRKRRARRERTTCSSGVDGDDVVVEQRQYGPESLRADCVKDDAPGCCCQLLDARVVTRRGGETVTSFTPLAPSARRRLILRSYPGPYGSWKSPPVVPSEATYRSDPLRMCPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVY0</accession>
    <name>A0A9D4SVY0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_009078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVY0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040709"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041865"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46713" checksum="123F934368A420A5" modified="2023-05-03" version="1">MPPVSGLFTDSMMAQVAARRAVVLADHGSILLQVTGFCERRNVRTFVVASQPLESSPFGYVFSRSIDERFFRKLFDKYRRVMETGLMPKWLADSKGNWQRCIQTRNIAVDSISLDDTVPFFLLWGIIMATGNATPFRILFHHEADAGMSMMALTYERHSVVRFGPCIDTIDFSMLSSASPNQFDAFSYIRAFDAEVWIAVFACLICLSCLAALGEWKTALTRSRKYCSLLGSAYGHGWDLFGLLFAESSPRRYVLASQKLLMVAWLLTVVVLANSFGSLLKSKQAVSTFKPDVDSVDDLAARPYLTPVIPSGNYYETFARHSRSLAVKQVWERSRSRGAMPPVSGLFTDSMMAQVAARRAVVLADHGSILLQVTGFCERRNVRTFVVASQPLESSPFGYVFSRSIDERFFRKLFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWN7</accession>
    <name>A0A9D4SWN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042001"/>
    <dbReference type="OMA" id="EMGDLPK"/>
    <dbReference type="OrthoDB" id="6474875at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039381276" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16808" checksum="EEBA89FBF6990093" modified="2023-05-03" version="1">MIGMLLAASWVLSGLARGSPLEDACGPQPNKKEMLSMLTAAADMFVDCYENYDKYGIPSKYLTKVLPTICSEYDGCLSSAKQGDGDQNEKIVQCIVEKIKAQLSGMEDLPKPADEVSEKLFGCSFRRPTVPVANRKNFFVCIHWYQIAVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYE2</accession>
    <name>A0A9D4SYE2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYE2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="15826" checksum="20B32CB58BA483EC" modified="2023-05-03" version="1">MTGVIPNCSKEPTPTSLYDTIKATLGKPVGEFSAGRFFNLPGTLDMTALACVIRHFEGSPSLGADEVPFLKCTLLGELAMTANNIKKLTQLPSRVAPSLSVTSVTRSVTGFGSLVPQGKILCVDLQPMKRRYAFGTMRRSCWQRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYI6</accession>
    <name>A0A9D4SYI6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_014370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYI6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7957020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="475" mass="53104" checksum="377CB2DEAD82F751" modified="2023-05-03" version="1">MDETSVADDTRDAVVHMATMDETSEPGQARKPETSAAKRSKKTRHTYCFAPGCVCSKTRHRRDHDGRRCSIFGMPRDEEMFRRWQRYVPPRANGQRLTPNSALCERHFDPQFVQRYFEHTINGQVVRLKRGVPCLTPDAVPTMFPDSPSYYTRRVPARRKPIQRAPLPPPKPKRRTSAKTPSPSKTVPEDASATVEEGSVVEPAPAPSECEAVIEVVECEVTPAFPYKDLPLPSGRWARHVISETPLVIAYSTCCLSDEQPGRLITEKLVLIREHENYAECQVYMDGRRLESFEEAGSTDYPQTLLQRLDGVRRCTGLGQPEDFHLNERLLPPSVEVRESGLHSVQCCGAGTTRAGLSEKCQYAKKLLRKKQARLERRMRMQDGPSVSEVVTDTERPQLVIADTSPGESVDGELRPNVEDDASATEVVTAEIVGDPLETGNNESESPPAMELEDNKTAPVPYHNVVLGQVAIYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ27</accession>
    <name>A0A9D4SZ27_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_013382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041875"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7961919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="325" mass="34736" checksum="B021A4C0B26FBEB6" modified="2023-05-03" version="1">MRLLFNQSTWVGGGFLIGAAEAVYKYGIIRCQAPFGYALSLVLGGSLFASKIRSTNALTMMDPFQRRYGHLVCVMLMLPAICAEVAWSAAVLAALGSSVRVIAEVNVPVSIIFSAILTFVYTALGGIYAVASTDVLHIGVMVVGLWLCVPFCVANKAANTIPWPEGNWIGTMSMDYANFIIDEFATTALGGIPWQVFFKFMLACRSNFEAQMVCFLSALGCLFLACPSMIVSAVAKTTNFTAFGYVGGHMLRDTDMHDVLPYSLHYLVPAYAAVVGLGAIASAVMSSTGASALSVASLFTRNVYFNVMRPNVSESARVGTLVPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZK2</accession>
    <name>A0A9D4SZK2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZK2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="13673" checksum="4FA35BEB00499112" modified="2023-05-03" version="1">MTDAPEDDVPGQHTPELTAYATPATEADIQHADLRTSPPSATVDAAGGSDSGRCRRPQEAATLAAAVDLAGDVTLEDDVVLLFTLPTAAFTLAAASWYHLSAASTASLVWALNLRRVPSGSRIRFLNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZQ0</accession>
    <name>A0A9D4SZQ0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_016997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZQ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039774"/>
    <dbReference type="OMA" id="RTIFICY"/>
    <dbReference type="OrthoDB" id="6499194at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="581" mass="62465" checksum="4F6A132EC8AF575C" modified="2023-05-03" version="1">MAAAPGKQLTPAQSSPSGSQAPWLCETQLPFGDGAFQLMNVFSAAIVLGNYLLHSEIFLLTAGVMDHWCRRPDSFANLSVDEWKQLAIPVDKNGEYSHCTIREPPDGGTEARVVRCTSWEYDYTKYGNNIVSAWNLVCDRLWLIDFARIVYAAASVIPLAASASFADSIGRRTALFIVIPVVLISAVASAMPNDLQFFMIVRAVVSASTSVLVPPAITLVTDASTIDKFPAYVVAVSLLSFILMPVTVLAAHLARTGWVAVQVILMIPTCLLMLLYYTVIESPIWLLATGHVKEAERVALCAAKMNNVSADVCHELMARQIADLRARGWQTAESSGLCSGRLRTRTVLMCCMSTALCFGFDTFVTKDGIPTGDVAASLSFALSAVACVATIPFVKQFGLRNAVVGSALGFAVTLTALAGTTYGGGGQTLNDSLVVPMKAAGNVCFTFFLVMGLKSLPVVSRCSGAAAMLAASRFGDTLGQLTPRLINDQSIAMRLAISGALTSLFAIGAELLPCDFDYWMQQHLSHQRCPRHPSPEGTKRAMRDTLVPLPKEPVQHRPITTKDRVALRRSTTQATGEQCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0I5</accession>
    <name>A0A9D4T0I5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0I5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056980"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="27"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="652" mass="71881" checksum="D72FA1F17DCC61B8" modified="2023-05-03" version="1">MEKPPVNEAPILHVVVVGFHHIKGYQMLLRRGSDVTRSSVQKSVCVLSRLPLYGVIQAKLQLVTHAYFDERDFSQVALLKETYQNLNALLSSDMMHGGQPYLGLSSRDLVLHFKHKAVLLFKLLLLERKVRLQVSTCNQVSSVLSSVHAGMLEQGLEECACTAGLRQLSSELRPEEHDFLEVHLSHSPSELKQSLDTLASEKNRQVKKKEFSSEDAVREEEVHSPEDLSLLSKTIRNSESKSLAKRAESFEDATDDVKSVTVTRKDSEEKKDKTETPRLSLGSVGKEFISKILPVSLGDIPYLNRITDDAVFEEEDKLVSEIDELLDSDPKEKTEMRQVMGCLESPSGVTKGGAPGAGDDSDFASELDGSMTPCEDSSGLGTLNLAGEGGELGNASALSSRDQDDLLLLQSIPKGSLCLPYVSLPTIDLLSDISIRSCVVGATNDLFKQKKHLFDVIVEVDECKITILDNDLRRQLYLTMEDLRFADYLVKNVLDDSRDLFLDGTCWQGGEEWLRSEFKVYLISLMKTAQLEDAVSSKDQEAFNTAFLSAWKTTHNFKMWNSVEHPCLSDIPTGSIQNSERGRKLNQAVVSTGKAMAQTTGKVVGGALTSAKSVVSSLWSHFSPPTPSSSTESVPPALPKEESVETVLSPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0S9</accession>
    <name>A0A9D4T0S9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0S9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8755" checksum="8B9850B6F0910856" modified="2023-05-03" version="1">MVKWSISRSPAEWCGTEPGRQESQTKAAEGHETANKAVTKKQEAAGAAIAINFNKRWGFFTKQVCYDEPQLCLFHIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T230</accession>
    <name>A0A9D4T230_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T230"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="20451" checksum="B3CA96D0DC58D474" modified="2023-05-03" version="1">MASSSLDRIVALLAPLTTAATHGGHERTQHVALTKMTLDHYAAPPPANVALEPASASTSSSSARLLDYLVDYLAAHRIPFVFDMGLDEAAAKDGAKEQRAGAEFEESAEGADDAAGSRNEAAPDADQLSSDEVSVENVRGEQHAHVNEEVVGKTVDELQDGEADDDQCRDGEQETAAEVVQEDRAKERRKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2D4</accession>
    <name>A0A9D4T2D4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2D4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055730"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19662" checksum="FAABF2E4FDCB4A6B" modified="2023-05-03" version="1">MNRAEAFTSSMYQRSGFRDYFQHQLSDTYRSRPPLTEDDSSTHVLMGLNAVSLLVIVSWVAYATLRRRLLKAVHHYLALYLPRALGKKDSHQAAKKAPKKLLPRASEKKASKRHLETQLDVATVTPTQPDVAGEATAVVPPASVHSIAEGPDGDEDLQDYEIIHTGDAFVDNEDHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5N5</accession>
    <name>A0A9D4T5N5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5N5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16122" checksum="B38D2EA8EB9AF045" modified="2023-05-03" version="1">MIPLSGSLLQQKAIEFVCILEQNHFKAHDDELPSADVAFDDLRAGGVLIPAEITLEGFADADKDLELCAELTDDEIIHQVTEDSDDSDTENEEPAPILPTNTELTRALMTLSLVYSGNMTLTEIEADIIAGKRTVQKKISDFFAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T655</accession>
    <name>A0A9D4T655_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_012336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T655"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043992"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7976346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="357" mass="39616" checksum="0E30C84BFC1F6B6F" modified="2023-05-03" version="1">MTSKGNIFVTGGAGYVGSHTVLELLNAGYDVVVMDNYHNAHPDKEGKMPESLRRVQELTGKTVTFYKADLKDQASIDDIFKKASHHFDCVIHFAALKAVGESWQIPLDYYRTNLGGTVNLLDVMRSHGVKKIIFSSSCTVYGVPKYLPIDENHPTGQSCTNPYGRTKYFIEEMLKDLSASEEGWSIVLLRYFNPVGAHESGYIGEDPQGIPNNLMPYVSQVAIGRRSELSVFGNDFNTRDGTGVRDYVHVVDLAKGHVATLDKVMAGKIQGCKPFNLGTGQGSSVLEVIAAFEQASGVKIPYKIVDRRQGDVDELYAIPNLAEEELGWKAEKSLYDMCKDMWNWQKKNPNGFLETAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7R7</accession>
    <name>A0A9D4T7R7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_016957</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7R7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049766"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7976603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12147" checksum="BD6E03A8058D0F0E" modified="2023-05-03" version="1">MPRYRQNHCYAPGCQTGYVLVKGGPKLSLFGVSKDKNRCKEWEKNLRRADKLLEDTSAVCELHFESRYVLRDYVHIIEEKQVRIPRGRPILYADAIPTFPANLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8G8</accession>
    <name>A0A9D4T8G8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8G8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18722" checksum="0A80A689FE5753D2" modified="2023-05-03" version="1">MCGQQHRRGCRNIETARVNPIHRVPSCFVLRFSSSGFAVYSNGTDCSFVFAHDDELPSADVAFDDLHAGGVSIPAEITLEGFADADKDLELCAELTDDEIVRQVTEDSDDSDTENEEPAPTQPTSSELTRALMTLLLVYSGNMTLTEIEADIIAGKRTVQKKISDFFAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T909</accession>
    <name>A0A9D4T909_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_009025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T909"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029333"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="86"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7983074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="228" mass="24954" checksum="5CA035DA925F444E" modified="2023-05-03" version="1">MSQEGTGVGVRGGRASSREGASHLLSEYRATSSEGILEAGDMDKEHNTGYRTEAHVETGSNGVCTFLLTAISIFFIILTFPLSLLMCIKIVQEYERAVIFRLGRLVKGGARGPGLFFIIPCIDNYTKVDLRTVSFDVPPQEILTKDSVTVAVDAVVYYRIQNATVAVTNVEDYGRSTRLLAATTLRNVLGTKSLSEILSEREAISHTMQANLDEATDAWGVKVERVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9F7</accession>
    <name>A0A9D4T9F7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_010871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9F7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050309"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038976">
        <property type="entry name" value="Ssk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692:SF2">
        <property type="entry name" value="GEO12064P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692">
        <property type="entry name" value="PROTEIN SNAKESKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="62"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="205" mass="22547" checksum="7524F1C89148EF86" modified="2023-05-03" version="1">MSHTVMVTRMTTTSSSPMVINTGYACNIQGALKVLETLLVPGHIHNKQVVNFRWEAGAEHCALFTGSSGVKPQAQVFGTICLGLMLHYTKPSKVDFFGMPGHELYFLLTAFGCLLCTFLLLVSSCWSFTSSSLLSRTSFEILFHLVACALYLAAGITLLTKTLDYHRNFRGEQYDARIAAAVFGIMNGALYLIGAILSFRIFRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBD8</accession>
    <name>A0A9D4TBD8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBD8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="13989" checksum="F4C02E2B643F5F83" modified="2023-05-03" version="1">MSRNKNPARHTRKLWWDTEVAQAWQARREANRAHRRAVKAKDPEVCSDKWQHYVKLKHEMQALVQMKLANANRQMLQDLREEGKSTAAKFWNYMSDRLIEKNSRSSKSWTAKHDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBJ9</accession>
    <name>A0A9D4TBJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055417"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="673" mass="76146" checksum="AF9E5E3D91D9A28D" modified="2023-05-03" version="1">MLFVIFTRPTSISFADHWAVEKSYRSEAVTVAAGVATTIIFCMFAYALFARPARESNVMDSLFCHTEDCEMQAHILQRWLNTSVDPCRDFDRYVCSKWVFAEGEKPFAGVMGYGLKKWADGLENKLGRATQYLKYATHVLAVFRKCMADISRAESRKGVRQLKEFMRELRVPWPEAPPAGVDPLEVVLDLSLSWRLGPWFDVTVLQYGDGTHNVVLQPATLQWEWFSIEQDILASAAHGAVWNGLYREFSLGSPLRSRSEVEQVVRTHDDIYEELRAAIRAAPTGQFQIDLRHMGAYTVNISADRQPFVLSDSVTFASKVSLKALNNIFLRHNDTALLKDLSWTFILLFSSVADRDFLTLKYGTPGMAREQRRSFCATEVDAAYRWIVVSLLVVVDFPRQSRDSIDASMNEITRTVASLFEKASWVHPDLGKALGDKVRNVSVTLWPSERLLTEEGLAMFQVGWFSKARTFTEHWISAARNWRSLTLAWKNHREVAEHPRNFLVPFLQYDHFLNAVRIALVTLSRPWYYAKGTKAMAYGSFVFFYALQLVRSFDAIGIQGESQIRGFPPARRPHSGNYGGFFPEIVAMEAAHAAYEAAVAEYERSLKVFPALSEDQLFFVAACITVCGLNNVFPVELRVSCNKAVSAMPALANAFRCPNDTAMNRAIKCAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC83</accession>
    <name>A0A9D4TC83_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001206">
        <property type="protein sequence ID" value="KAH7984884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC83"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14419" checksum="243BC82CDD076B06" modified="2023-05-03" version="1">MPVCEAWNCENDSDHCPGTTFHKSALAHEKPLDVVEIVLDSSGGPAKTSEGSESSSLDHCYGTPLSTTPATPTTAARETTATRRVRLPEEGDTLRKKLKLSRQRVRRLEERVSMLNDMVYSLLNQTIMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCN6</accession>
    <name>A0A9D4TCN6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000971">
        <property type="protein sequence ID" value="KAH7985362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCN6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042363"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047412"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="708" mass="80390" checksum="AB406B00088FA7D5" modified="2023-05-03" version="1">MDGGRLLPKNVETLGCVERDIQTIGLPTIIIGDFNAHIEDLDGKTDRMGRYLLDWADKEGLVILNTSDKCVGKTTWAVSDKQTCIDMYCLVSPIQFPRVVGMSIDTTGAQSVGSDHNSIWIELSSSYRPRPGVERKERHHALPEWAIDKLVETLENSVEQVDTDEYDVFEQWVVDNINSVTKTSNPATKTQKHRRKAWWDKEVSEALFKRKQACRAHRQALKHGSTGDNILQLWEAYRVAKRHMASVVQKKMRAINVRLLQNIKKAGKDSAKKFWQYIGTQQPPVPQTQASLQDPDTGQALSEEECLRLVEKHFSAKFHSMASAAEDTDPETRKSLSPCDTITARELERAIRHLSGNTAAGLDRIPALLLKKMGSTVRQLLLAVLNRVLLSGEIPKSWNRSRIRLILKKGSDKRHLESYRPIAVTSVLYRLFCCILRQRMMSWAEESLEREAGRAALGVHKGVPNEAVQGEVGWSSFEAREAVSKLAYERRLSQLPDGRWAREVFKYIHLKCINTKWVLRTKRLAERYEVAPCRLTEKPQWDRRTKVREAVQEAESASWRTMVAGKPALSFYSKAKQAIEKEPLYENSKGSGLLCEARCGMLRTRLLRATYTPNLDTTCPLCTLEEESIEHIVLRCPALKPQVSATSSAAATPPEQRQKLLAMALGFRESQEQPQWETVEATKRRLEHWWCANYLQDRTGPAANTPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD37</accession>
    <name>A0A9D4TD37_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000717">
        <property type="protein sequence ID" value="KAH7985785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD37"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="37269" checksum="367B7BE604E118D4" modified="2023-05-03" version="1">MTTRRQIHAVSWSVTPSPVPASTPADPDEFSLEGDDVLGRLQSLADDADPARAAASSRNDPGDPGEEDDAASSVSDATAVVPGLATDIGSRVQRRARESEDELSRYMSESSNKVPVSARNFIMSRVFELVASCADLRVEAASERGAALALRGQLIEARREMAAMQRTDPGASSGSGAIPGRVAGPCCSGVPGAPSAMPPGVPSYAAALTGVHCGALPSHGAQNIDPDAPTPTLGAPARGVPHACRTGHDACAGCPTSPEDQHRPGVQRHRGRDPPPHEGVNPEDKTLLPMRLVVEDLGSDFIQLLVDIAYHIPLHDLVGPHNVADVLDLSEKLKLSQLRSHCVEVWSATFNRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDA0</accession>
    <name>A0A9D4TDA0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_025267</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000622">
        <property type="protein sequence ID" value="KAH7986005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDA0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046154"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7986005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="333" mass="34762" checksum="392E1A8A83C4D83E" modified="2023-05-03" version="1">MNCTAPFCGRCGTYGHDGKGCSLPCRRCGDPHATVACTIRRSYSEAASKDFPPLQPEDASYGQSPDPASASTADDQVCVSRPPVITIERHAGKKVKLKDVEVLTLRQGQYTTGRRSSPVPQLTCLGGSAGCQNAPAVVQCYNRGSDGYSTQWECKADMSKSQKFGTVEVTCEGYDYADDEYILAGSCGLEYRLEKTGYTAGSTYDSYKHSTYTHGSKSGSAFQMILFLAIAAFIIFTIYRTCLAPGQLNDAPPSYDDGPPPDYPGPPRGGFFGGGGGGGGGMPPPPGFRSQYQTDASCGTARAPGAAGGIGGGGFWTGAAAGGLLGYLLGNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TEB6</accession>
    <name>A0A9D4TEB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_025376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000007">
        <property type="protein sequence ID" value="KAH7989027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TEB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040596"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="551"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7989027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="637" mass="70752" checksum="E648FF5DCB59B8E4" modified="2023-05-03" version="1">MQARACPSDWLYGGLALLLLATVFVLTKLWMAMPDVGNAPPGLCKSTDCADHAAALGVGKYDVAGRGTRDPCQDFGQFVCSVAEIRYPWSRLPVMTQMLVDYVVQLGRQLPTVAVLAKAGLAMRTCLDTSTRNDEDVEHLLEFMQGRSFDWPADESDLVDPTDYARPLKALVELTVKWALPLWFDIELRPSSSGQGRTIVQTSSTRALVWRELHAEAEMLGLITIYVETFCSALILRRRAAPSFVAFVRQNSLDVQSLIFRHLSDAVSASIRDPKLMHLRTLSTKEHLPQLQPQDWAHALQWAFHAAPAIAPDDAFLATNIYVIRSMRRIFESLTAREVLFHTTLWFLQEVGPLASKTLSLFTALSEASNMLNSISCGLHIEAVYHAALVMKSKLEFSAPQSATAWPWGELSVLKSLEHYYGPTNTAPRSAFDEWLSIRLHVQNFAGDRDLATKVFRIESSRLANYDLIDNVILICAAALTAPFYYTSGTSAMVYGGLGSILGAEIAHTLHSFPALLKEEAQILPSGERLLEILWGISPCNATYGLFPAVAGLQLAHSAYVRFRYAEDDVPLALLKNYTAEQVFFMTFCLTLCDYDYNRGWASQICNHAVKHLPAFARSFNCPPESLMSTKPVCPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQT5</accession>
    <name>A0A9D4YQT5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_020073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056835"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09360">
        <property type="entry name" value="LIM_ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000073">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7984375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="239" mass="23993" checksum="488ECC58C9E982F6" modified="2023-05-03" version="1">MSAALSTADFSSGGSSSPAPGGPSPVAAASSPTPSPLVNLRHVEAPKTAPAPPAGQPNTSVGAPNTCADCGRLIVGVFVRIKDRALHAECFRCATCGTSLKNIGYFNIKDKLYCDIHAKQAARHIAPGSSLEPVPVPPGGHIPQGIPLAPAPAPAPAPVPVAPRAPTVGAASSPLYTPPAPKFTPAAPYTPTQAMPAAHSPVAAAPLADQPPPPPDSPGICYDSPVAMGVSNLRKVFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQZ6</accession>
    <name>A0A9D4YQZ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027155"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="121" mass="13113" checksum="82632C8F1F125EB7" modified="2023-05-03" version="1">MAVSSSLLYSKQNPKHSGDGCDIQYSRDQERACFESRRTIELCEARFGAALIQCNMVCLPQPAPSGQRRFSPPPQSVPALAQASPVADQDDDYTDAGQNRAQGVVRRPASFRQAVPASTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRD1</accession>
    <name>A0A9D4YRD1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001053">
        <property type="protein sequence ID" value="KAH7985205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRD1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032720"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="3">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7985205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25823" checksum="99AFBBB88AAD3357" modified="2023-05-03" version="1">MLRTEGPQRWIFQELQELWRIAFRFKGKDTPQSYVRDLAGMLHLFPFQDVLAGPYLLEEYRPDLINDLLHYLRPDNVRIAVVAKRFMGQADSVEKWYGTQYNLEPIPDSVMQDCVAEAATVRPRDGATVGAVIIIMRMDSGDVARGVPGTLENFCLVSGIDEAKRLSNVVPAALEGSAKLWWQFVGAFNSWDEFTKTFRAEFASIDSKRRLKEELEQRTQHPRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRP6</accession>
    <name>A0A9D4YRP6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_025217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000589">
        <property type="protein sequence ID" value="KAH7986090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRP6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034561"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15737" checksum="6E7DE2066327A967" modified="2023-05-03" version="1">MLAQTTDTDAPIAVANTCLKYCLLNTKFVLSRQNFRRQQTAGGSHRGERVDYTRSPLCELSRYLHRVLRALRTPFEVQDVCRILKFSLDNTNFVFNKQYFKRVFGTAMGASVSVVCANIALEDLECAALSSFATRARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAF9</accession>
    <name>A0A9D4PAF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001480">
        <property type="protein sequence ID" value="KAH7932441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7932441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="389" mass="42523" checksum="13871A9FE6D3C62B" modified="2023-05-03" version="1">MPHEAMVEGEQISKEEAESNGWITAHRKRNADKTRLENETRTAGHNGARVGARNSGQLRKVAAASRLPRLPKSHFRVVVRPGGGLDVRKCSQLKVTQAILMAARLPPAAAEEDIVCANAMQNIFVISTPSESNANAYSTVQEIILADKRHPITAYITPPGNTCSGVVRGIDADLPEAALQSLFVTPKNPMVLGVRRIKESTTVIVLFNGMKVPNYVHCGPNMVRCTLCKRQIDTCRNCGRVGHRQDVCPRPTEKVCDMCGTLTTTNGHECVQPKCALCGDAHLTGDRTCKNRYQVPYVVRRRRRRRRKRGKKKNTTSNAANAGGLEIPASTKTPTAAASRNATPERSRSRSRSRSRVRINSQPTWADKAAKTGAGLPKAGSRDCKALIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAK1</accession>
    <name>A0A9D4PAK1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAK1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030759"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048225"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30122" checksum="8FE57724E8323EB5" modified="2023-05-03" version="1">MLERQPQRGTPNPFTTVALQPRTRKEPLKVDLRAAIDMIMAAWWQVKPSTIKKCFEKEGFIRNHGTDVPTDDSDDQPVCADEVWSEYITNHVVSESDTTEDFLKDIDDDADMCEKAATDEYIVAVVRGDEDEAALESVTGFDASAGWLFRFHQRNGIIWQVVSGEEKAANKEGTNSWWNDSFREMAESFSEDDLFPPCETACFYQLLPDQTMRFQGQQCKGGKKSHLHKTVLLCCNASGTENQATHHRKVRKAWLLEERRIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBB9</accession>
    <name>A0A9D4PBB9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001580">
        <property type="protein sequence ID" value="KAH7932372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052108"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13254" checksum="1E8D5406C1F872A2" modified="2023-05-03" version="1">MDDAPDAPISDRPNADTEPRDSGCEIDAAVEFISASQKKIGFFESEPRPVGAPTVNTMLCEIGALTALVAGSARPTCRERKLGVREAAGKRKELSAFLELCCENSDCPESTLSSTHTWRRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCD3</accession>
    <name>A0A9D4PCD3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCD3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="12993" checksum="5AE757682607766F" modified="2023-05-03" version="1">MQAVASEVPLVQAFDEHVYRARLHCTIASRKLSNSAPAPLPTPRYATGGERVSKYVAFAGDVITCPDPRLPAFASGNHAGSTLLLHERGSARFRNNGQYEAMGTTTLPLSLRDLITMQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCY5</accession>
    <name>A0A9D4PCY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042881"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="31182" checksum="273626D996A31529" modified="2023-05-03" version="1">MRWPTMFVNDQNHRRSLYGMHAIVLLEWGLDEGIAAETKKETLLECGVFATSGGRRQFERSDPFLVLTDEQFRQHFRLSKTSVRWICDELADHPRLRRLRGGPQSLTVAEQVLCALRFYATGSFQGNIGSESYIGRHQTTVSRCIKDVSIALVDTAVRKRWVAFPRTASERAYIKDRFLRRGSITGVIGCVDGTYIGIKAPSKSNRTVLKANYFTRKAHYALNTMVVCDADLRILHIDARFPGSCHDAHVWGKSALRRHFELGHLLDDGDCLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD21</accession>
    <name>A0A9D4PD21_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD21"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039370886" evidence="3">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="16548" checksum="4635BDBEF9BBA574" modified="2023-05-03" version="1">MALRGLVLLAALALGGAADNFKWTDCKGMPSGVTAKTPQATSPYQLTAAAPDHGMIEVTIPTGKLKFFRITAMEDGKETMPKGEFMLDAGVKAMLMKCDTMDKPDSGGKTDGGNGGKKDAGGDGKNAQTKGAASCTGLSAWLVIVSLGLVVLLGLGNSLSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE36</accession>
    <name>A0A9D4PE36_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_009684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE36"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028753"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000139">
        <property type="entry name" value="Estrogen receptor beta a variant b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="106"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7939251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="20114" checksum="19B6C05445BDB26C" modified="2023-05-03" version="1">MASSGLVKQEEEPYELTMYSSSSSLSPGDAAPRKLQCHSPSLSPPLSPREFSCSSTTSIKHQAPPSPPVTGHGSSGGHSTRGSSGHHHNNSNHHSGGGGGGGNSPRRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGNIEYTCPASSDCEINKRRRKACQACRFQKCLKMGMLKEARASRSSVRTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE42</accession>
    <name>A0A9D4PE42_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_009738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026092"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000420">
        <property type="entry name" value="serine-arginine protein 55 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF53">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7939266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="239" mass="26671" checksum="AE682305F059C2BD" modified="2023-05-03" version="1">MTTRVFIGHLSYQVREKDVDRFFKGYGRVGDIHLKNGFGFVEFEDHRDADDAIKDLNGKELLGERVSVELAHGSRRGPGGRILAPGSRDWRSPPGGGGGGGGRYQGGSRDSRFGPPVRTNYQLVVENLSSHVSWQDLKDYMRQAGEVTFTDAHSNRPNEGLVEFSNYADMRNALSKLDNTDLSGRRIKLYESKKSRASNRKSRSDSPRNNRSRSRSASPPQRHHSASKSPPSKRNSPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFI4</accession>
    <name>A0A9D4PFI4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFI4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="22811" checksum="2E25EFB668E07516" modified="2023-05-03" version="1">MRLRSSEETCWLCDNRTAWNRMMSVLDLALDEWKPGLLLLWCSFDRKAGSERVTAVRAASFLASWLLCHHSYVEDGFLSCRTSISTPVEEPPSHIHLHPLSSTATSRWLRGMNINNTYSAILSLRHLDAFNGLEMIYIHADEINQDFHAQIDELVAHNRTTLNKVDILEFQKTRNGHTKVEKPRRLRVSFAEVVHNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGH0</accession>
    <name>A0A9D4PGH0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGH0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040057"/>
    <dbReference type="OMA" id="RTRMKSA"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="403" mass="45702" checksum="2D039AC40221F993" modified="2023-05-03" version="1">MRAIGLPFGLYHAIEREMANRSDWSDVIAMKGAREVLRGVRYPNDATRRSLYASWLRVVASDRWEESFDHVMLECVAATPSPSAPWKPLFANIYRVRDVMDLPFPDVPTPVLNLLKMPRLFERRPESVEPLPSSPGFVDFLADLIRKSDSSRAALNEAGLIIGFYSLALSLVVALPVREVQDFFRTRMKRALAAAVPTSFDGDAFCANGRFLTELARKTFSEKGEVKPYLVLLVLGQYAYHVHAREAPPSADVSFLEEGFLTAAKFGQLKIIRLLYHVQEKTALSAKVLNRILRDSGSEEVALSSQRVREFLEGADEEMQKTRPWCRAASVCFFVHLNVEDHLDYVMRLTAFLAPDPNDLMWQCPEFADVPASRMKDARLWARNFKRALRKGKYGTAVRLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH12</accession>
    <name>A0A9D4PH12_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053722"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF23">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038615073" evidence="2">
        <location>
            <begin position="28"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="631" mass="72355" checksum="63F1D4534AE6FD27" modified="2023-05-03" version="1">MANPALTSRHRHLAVLLVATVLSLALATSEQQQQRGSKDKKKFDYCVIGAGPSGLQMAYYLKKAGRDYRVFEKSNMTGYFFGTYPKHRRLISINKVHTGQQNPEYNLRHDWNSLLSDDPSLLFKHYSRDYFPQADTLVKYLDEYRRKLDLSVQFDTEARNIRRLPKETPTGHRFQFEDQRGETYWCKYALMANGMSRPNEPYFEGHAMTVGYEDVSTDQADFEAKTVLILGSGNSAFETANHVAGVANYVHLLASSPPRFAWSTHYVGDLRAVNNELLDHYQLKSLDGLLEANLNILQLVRTQSGKLALQLRNDSSFNYAPPDDEYDVVIRCLGFTYNDDMFSPRTKPERAAGRRSKFPLINRDFESANVPDLYFVGSTAHSLDFRETAGGFIHGFRYTSRALHRLLEWKNHGVPWPSERRPLAQLMDAILTRVNEASGIYQMHHFLGDVIIIDRNTLEFEYLQEFPLPLLPQFEEKTGHKVEGKEVIVVALRYNPDFTGPRLDTFHSDRAVEDVEKAHLCNGLAGEHVEELENRHGNPSIPVPDRIHHMLEDFLTRWTSPHLHVEPLRRYLESCLGVDLRRYRSTECFAKLLDGAAEDVASPLPLSCVQRPEFETSHFLHPEHGHTFAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHE3</accession>
    <name>A0A9D4PHE3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_001581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHE3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034174"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052270"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="8">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7942799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="406" mass="45235" checksum="CC25E6EDA7FA096B" modified="2023-05-03" version="1">MKKRFHGKSRGARHSAGRANKQERLTCDDTSDPRPESRDSDDEGEEKVRWPFSVAMWELGHCDPKRCTGRKLARKGLVRLLRLGQRFPGVVLTPSATRCLSPEDMHVVSQHGLALVDCSWARLDEVPFSQMRGGHPRLLPHLVAANPVNYGRPLQLSCVEALAAACYITGFEQLARECLRPFKWGHAFLELNGELLDAYATAADGAAVLEIQQQHLEQARWDRQNRGKLSFFQGLLEQVGDMELPPTDSSSTDSSEDEAADESTSSQTQEQKSTDEAPAVSSEDSSTFDGHIPEGELEISFSRSSGPGGQNVNKVNSKVEIRFCLETATWIPATGRERLKTQWGHLVNRRGQLVLECDDQRSQLANTRICLDRLRSLVTEACRPPPSGPDEAIQRLHEKSPITLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHQ4</accession>
    <name>A0A9D4PHQ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_021860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHQ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057406"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052547">
        <property type="entry name" value="Mito_Isobutyryl-CoADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831:SF1">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="81"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="186"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7940111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41008" checksum="13FD0CABC75E1B32" modified="2023-05-03" version="1">MRKAGELGFGGVYISDQYGGAGLSRLDASVIFEALAKGCVSTTAYITVHHMALWMIDQYGTHEQKQRWLPDLCSMEKCASYCLTEPGSGSDAASISTTAKRDGDDYILNGTKAFISGSGASEVYVVMCRTGGPGPKGISTVVVEKGTPGLSFGKKEKKLGWNSQPTRMVIFEDCRVPVSHRLGEEGQGFTIAMEGLNGGRINIASCSMGAAAASIDIVTEHMKVRKQFGKPLASYQHSQFCLARMATKLQSARLMVRKAAEAIDQDRPEKVTMSAMAKLHGTEESFKITNQALQMLGGYGFIKEYPVQQYMRDLRAHMIIEVPTVCQAMELRPASGHVLHSAFFRECRLLLKAEQRVLCLKVFAMQLRGDHNGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI55</accession>
    <name>A0A9D4PI55_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI55"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="14839" checksum="28947FEF3AFF6A20" modified="2023-05-03" version="1">MATSQYYGSFFILYADDVTVSTLQPDVESQQNDADLFEPKCQALTTVSTILVLGVELDASGSASAVEALTAERVKGVPAAAAVAHYYNRTLRHLCRTLARNSAMAQGTGQRQPTADSPTTMKQSSGTGARHHDYASTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKQ9</accession>
    <name>A0A9D4PKQ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_021355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKQ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028528"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7944538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="382" mass="41610" checksum="73DA2FAB96B36136" modified="2023-05-03" version="1">MAPDVILLQEPNCTPSLAGFEAYGSDSEFSKLGDKLLICGDFNAAHSVWGYPKNTGKGTKLWDNICNMRFTLLSDPAQPTRVGNSVSRDTCPDLTIIRGTGAVISSGPLDETLDSPDRLLQELQARYIPSGASPQYNPYPYVTDMPNALDAEITIQECTRRAVKGEVSLHTFPSDNRVKKEWVVKLRIGKPVTETMRVCSAHFVPEDFFWGTTGLHAADPLDGLQNIPCSPPQNDPEGASLTSEASEPESTGNMVKENTKEDDAAEALVLLGAHPTEFEGVNSAAVESLLQFNRTQTASLHKAVQVNPCTAPSTCRTLVDLFQSDACVKAFTGVEDMRLLMTIADAVAEVDNLKAERIPKCHFMELQFLKLLHVAASKNVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMH3</accession>
    <name>A0A9D4PMH3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMH3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027493"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="19124" checksum="11630580E3F273C7" modified="2023-05-03" version="1">MDQTMVTNNVVGESTIRIANTGCARRGFTICLAACDTGHKLPAFIIFKEQSGKIPARAFASLRIPANVRLTATKNGWMTSEKMQEWLSRVWGPNDDVQRLLALDQAPIHKTQAVTNAFKEYDTDVLYVPAGCTSILGLADVGAVVPEDRGGLQVECFDLFFAADSEESFDGFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP69</accession>
    <name>A0A9D4PP69_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear export mediator factor NEMF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_013936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP69"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056685"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="9">
        <location>
            <begin position="494"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="10">
        <location>
            <begin position="897"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="703"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7947591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="110645" checksum="74549F8D4B26B30C" modified="2023-05-03" version="1">MKSRFSTVDILAMVAELQKSVVGMRVVQVYDVDTKTYLFKLSRQEEKAVLLIESGVRLHTTEFAWPKNQSPSGFAMKLRKHLKNKRIERLAQLGADRVVDLQFGTGEAAYHVILELYDRGNVVLTDGDYLILNILRPRAMGKDEDVKLVVREKYPVQSALAEPPSLDAQQLSEVLAQAAQGDTLRKLLTPRTLYGPALLEHVLLGHGLSAGAKISTLPAEGLTEKVLECLHDADTIMARAKTESCQGYIVQRIEKRIQPAEDGSTEIATYQEFHPFLWHQHSSGTGAISTIELPSFSAAVDQFFSSVEMQKITLRAHQREKEALKKLENIRTDHEKRIQALQEVQQADVRKAELIEMNLDLVERALCVVRSALANQIGWAEITELLKEAQEQGDPMARSIRKLKLETNHFEMLLKDPYDEGEEALVDIDIDLSAYANARKYYDQKKHAAGKQQKTIESSAKAYKSAEKKTREALKQVALTTNIAKARKAFWFEKFFWFISSEDYLVVGGRDAQQNEAIVKKYLRPGDVYVHADLHGASSIVIKNPSGAPVPPKTLNEAGTMAICYSAAWDAKVVTSAWWVHHHQVSKTAPTGQYLTPGAFMIRGKKNYLPPSYLIMGFGFLYKLDDESIERHRGERKVRVAEDETEASTEPPEEGPELEMSDESDSEKGSAKGDGDADSTKADAELFPDTVVKLPHELETAMTEHDDHDAAEEIVYSQPTRGPQVSRKPPPAKPKPQPPPQEVPAGANAEKANKPKRGTHGKLKKIKEKYKDQDEDERRLRMEILASAGVPKETKSRKQKKGKKDAGQVVTSKGKQLQPKAQHKPLAKPEQPAGTVDTNDADKPAAENAVEQGSKQEDVKEKASQKEGSNKAAVPVEDDDLQADPEEDEDEGSVGDEQQRLLASLTGCPVAEDGLLFAVPVCAPYAAIQNYKHKVKVTPGTGRRGKAAKTALSVFLLDKNTSPRERDLLRVTKDQDISRNIPGKVKLSAPHLQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPH7</accession>
    <name>A0A9D4PPH7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPH7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043760"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053064"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="398" mass="45062" checksum="FC0492B67CE7C0BF" modified="2023-05-03" version="1">MTQEGQQAQQVHTTMVTTVPRLTVYAFPPRFRDFDPNCVRLVTRGGDLYTAVPCLIGFMKLFCRADYYKTCRRYGDIVDYLVFSTDLVTLGEIKAYKSMEPHDYFTSGWVKSLSENELRDRKLDRACKVLQGSDEDCLWLEEVKIDGAVVRRWLRHMITGSVPAATMDDVYVLFGVLLCNVNSKDGTDFNQEWFQNRVNDLVALFPAVSEPPPVPLYSELQAAALSTFGEQWPYTAAQIVCTIVEGRFQGPMKRLQKYVCEQWRIAEMTEAEPQEVLQGSDEDCLLLDEWHIDRVLVDRQLRNMTGSGPAATMDDVYVLFGVLLCNVNADGTDFNQKWFQNRVNDLVALFPAVSEPPPIPLYSESQADALAAFGQQWPYNAAHIVSTIVGGLFKVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ09</accession>
    <name>A0A9D4PQ09_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ09"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026874"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="23341" checksum="36F7EF3478111923" modified="2023-05-03" version="1">MQWLQLPPRVCDFVVSFLAHRTFCIRVGKERTGHFVTKRGVPQGSVLAPILFNIALLPLAWQLASIPDAFFLLYADDLTVWTLHPDLQRQQHALQSALDKASDWCARIGLTLSATKTAFMSITNRRGRRRLLQTPICLSLNGQALSTVSTIRVLGVELDASGSAKIPPWLKAQASDNRPLTRLRQSNRQVEQEAVVTAVNDSLAFDVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ34</accession>
    <name>A0A9D4PQ34_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ34"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029187"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7950778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18448" checksum="845C7956C53621B5" modified="2023-05-03" version="1">MVGQRSRRPCSSNGATEDNILQVWEAYREVKRDMASVVQKKMRAINVRLLQDIKKAGKDAARKFWQYIRSQQPTLPQTQAGIQDPDTGHALSEEECLRLVEKHFSAKFQSLENEIKSTDPEPRMSLHPCATITTRELERAIKHLSGSTAAGLHGIPALLIKKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQD7</accession>
    <name>A0A9D4PQD7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQD7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="11602" checksum="753014AF19EE7A25" modified="2023-05-03" version="1">MRMRLLWEAVAVEKPELGAPKGPPQCSAGRTARNAGATDDGSRMSGAPHSAVAAYLGVRVRPHVGSSKPIEEKITHQSSTHRDAHVVTAHRGFHRSVIEQAASLKHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR25</accession>
    <name>A0A9D4PR25_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR25"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="31405" checksum="BD5ADA5B7A403A8B" modified="2023-05-03" version="1">MGMKGREKRRKLIRRSKSAQDTRNSSSALWARLRIVPCAFGNRNDRRRVATRSYIVTDWTRFRELSAASPPSGAAFFTHVSRCVGAASRKCVVPVGTPVPDIKLLNLRAVRQRHQRRATKSERPELWTLYNHLDAKCRRHAKRRRDQSWDSLCGTLEDPRRSAKAWRIFGAILRPVGTRFPALAIAVARGLSYQQLAELLADTLCTVVAGDATGIPELPQHHRRELMTPHRFLITEGIQREVSSLCNAYFTLGELRLALASRKRRSAPRPDENLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR98</accession>
    <name>A0A9D4PR98_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR98"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036747"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81547" checksum="B33DBAC4C014A2F2" modified="2023-05-03" version="1">MARSLVMPKRKRATADQGGGSRRKPRSLTSDFVFENSRFSGSSINYRTPCTSSEGQLCDIFRELTIWNEFFWEVGLELRELSPGQISLVKVDGTLVTSEIPRKHEAAMLLHRLLMCHRCLFSVVLNSYILVHHDEMLCDELPRSVSLRQLQVSLQGRDMCALRTFAAVLPLLNNLQEIDCRLPILERTFCEGLSKLLRSTASLTTLKLSAPDAEPKEGMVILHGLERNTTVTTLSVTMCMKLFLFQCGVVFADYLSENQTLRTLMVTSDCAYDDNVPNLIIRSLFRNTTISEVKLIGFNLDVKNSYLVAKLLSENRSLRNFHMVKSSLYGSGRIPETDGVSGRIRPWIVALGKNRTLERLTMELSCFSLKECKSLFKVLASNKSLKNIAVERVRPTDEAEICRLLLETGVRERFFLPRPHVVEDPAVTLTECKELSGVTINTDTPRGLDSLHTALCLLPSCSHVTSLTLDLQQQCLNGDVISLMAQYFTSTTVLRDLQVILFSEVNTMDRAERVLMQALFFNKSIRKLCMTGVDFDETEIQMLVDKLEASRTLYELSFYPHDSMSTVLLIRKLSPNVSRNYTLLSMQVHGYLVDWVPSRELFTVNDVVGRNLSLVTRAAHFVMGTRNRYCAAAAELVHSNPGLVAKVQVLASVDENEASSRIETSMKSFSELDDFMRMAGVVKHSVTCHRRNDGQLQLTDLNRDCWLYVRQHLKIGDIPNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSC7</accession>
    <name>A0A9D4PSC7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSC7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="14947" checksum="E4DE005FA51AC13D" modified="2023-05-03" version="1">MSNDALGQGVRRQKSDDYLRNKACLQRERGLLEPDAAYDSNSVLRAALAVRATLEAVEASPRPLRSRFERQMFFRRVCFLTCSRTPDQAPAAGELPPRLRCNLAVRNTGLFHAAFRCDPRRRLARAEVCELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT74</accession>
    <name>A0A9D4PT74_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT74"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18140" checksum="BE9C0103A4DB6CBC" modified="2023-05-03" version="1">MSLSGDNTPSQLTSSEASRLSNASLPASESTLRMSLASESSLYVEDQAGGQRRKPPILVSAGERRVSRRRRGRRITWNLTPDFEPTATECSRRRRSFPAIACLAVAVAACTCLLVLGSFSLLDTYRYLVTTLDSGTSEHKTSSDFKCDSTRHQIRLDSQPQGPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT83</accession>
    <name>A0A9D4PT83_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT83"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11676" checksum="002F04020CC39AE3" modified="2023-05-03" version="1">MKKLRDSGGQWISDLSSVPQVTSDVIDNHFGESHRQLIKGWMFKEERYVRRIECTTQRQPTGLDLVVLHESGVLQARNNEWQKVVYLEPLVNHNAISRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT87</accession>
    <name>A0A9D4PT87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045182"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31649" checksum="3A82476CF98C3120" modified="2023-05-03" version="1">MSLFMGKFVEEVNNFGHVIWRTACSVIKSTIHAICCCVDAPARAAVMSMVQFNGLFGCPWCYACGEHHERGQRYMNVVADEQRTPESVLRDMKFAIEVSEPVNGLKGPSPLARLKGFDLVLGQTVNYMHCVLLGVTKCFADTWFDSSNHQEPYYIGILPQRHLNHFVLLVEAVHILLLEELTAPQLQRAGSSVSAGKRPPARRQDTRKAPKQPSRQPEPAAVSAPRTKTQRRSVATWTHQDDHEAPRYFVGDLPWKTQRQLRREMPWPYDHGGRRAVTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTJ7</accession>
    <name>A0A9D4PTJ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTJ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="101" mass="11306" checksum="3E68AAC85E233A96" modified="2023-05-03" version="1">MRVPRVTKTWRRGTLSLTPELCPTVAPSARTSVPMLTTEELTEAEIVRAVTGVVNDDSDECVDDSPELVYPMFRRPRKRWMRQTCCAASSALTMTARTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU87</accession>
    <name>A0A9D4PU87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033998"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="248" mass="26115" checksum="924339F99EF19863" modified="2023-05-03" version="1">MPPLKQRRLDAAAESSHRTSVEREDTGQLDDADSELPQHGEPSYTSLRSETNARETQPSTSSSVPEGERDKRQVDEASKDQHEPVKGVDTAPTRRDTPPEVQPPVSVIEAGEKCMVCSHGEGSPMAGKRPHESTVDRAAQEGTSEGDKPRVAPGTKAENKAGDDDAKAASKSSAAAREFSPGATDIEMTSAGGIASKRAREASDSTGNVGTSGTGEPPKKTATGRRPTLKPRPNLPPDRGETPTPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUL6</accession>
    <name>A0A9D4PUL6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-CoR GPS2-interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUL6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038958"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031557">
        <property type="entry name" value="N-CoR_GPS2_interact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15784">
        <property type="entry name" value="GPS2_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-CoR GPS2-interacting" evidence="2">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="253" mass="27495" checksum="E0DCE3E3F95EAFC8" modified="2023-05-03" version="1">MSKVKTLPAGHLYAAQPAPHHHHQHLALGHDAGSPYKRAGPLSPPLAGTRGYPYPQDPTRTHFSPLLNSTQQSYRDAFQLASCDDRRLVFMRRYLEAYRFPHYEQRDMGGGLVGLVGGPPGGSAAAAVAGAAGGLVEPLEVVHLNKRPRLALQQPLLIDTSSPHHHHPSSSSSHLSSQHHLMGGVEVKKEPAAYVPQTEAISPTLPGEDGRPPLSPQGRSSKDDLLSAINRIDREIAQVESQTNKLRKKQYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVY2</accession>
    <name>A0A9D4PVY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVY2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038798"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="16029" checksum="0B4CD4530F0FEC11" modified="2023-05-03" version="1">MSCLMRCRHEPAPLKSEPEEIYGNITNKTGPLQKFLLDITNHTMQCCQKNNAGFGLGDWLTMLTTVVPGSVTRSFQSRVSIELTGTHTRGELVFGWMPYMLPEVTRNVTVIQELNSSMVNRVFQETFDPSSTQWRQTTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWT5</accession>
    <name>A0A9D4PWT5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029140"/>
    <dbReference type="OMA" id="DAGHEGP"/>
    <dbReference type="OrthoDB" id="10600351at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="28143" checksum="CA10A97879873080" modified="2023-05-03" version="1">MASRRRGGDAGHEGPSKPPKLSRGVGGRRTGRLAPEVSTPVPAARRRRKTGTETSAATAAPRSTESSGAQRDTTSAKRDTSSPATPPSSDCVASSSSGILSVATTATADPSPSAHSSEDDEVETMRWHGDREDQLDPASDGGACGSSFVVSQESGSGSRRASSVVVTAPGRVGSAFDGPFNSTMVEGAVPIHQMPLPSMTTTGGQSTRTLVPDTEDGALDDIPQPLPPPPPPLESSPTVVIPPCPLGLHRQMQLREMRRHGVLYSWELPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYB8</accession>
    <name>A0A9D4PYB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053977"/>
    <dbReference type="OMA" id="MIAQVTF"/>
    <dbReference type="OrthoDB" id="6505378at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17209" checksum="6985836713BD53C5" modified="2023-05-03" version="1">MIAQVTFAILVGYASCLATHYGAGAGHYGGGAFGYSGGLIAAPAVIKAVAAEPVYPPQPYEFGYDTVDEFGTRLTRQESSDSANQKKGSYGYTDANGIYRQVNYVADAGGFRATISTNEPGTAPGETGGAVFDAKPVAVVDKHHVKAAAAILAPTYAVHPGYYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYJ2</accession>
    <name>A0A9D4PYJ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027653"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15762" checksum="9BBF2304E98C4ADE" modified="2023-05-03" version="1">MSTLGLTLHTDPAYPTRVGNSVTRDTCPDLTLTKNIKYADWVNTEETLGSDHCILNTTIRTHPLAKPYGEAKLPDYTKFRQIYANSTPIEEQGYHAWSQQLVSTLRSTETQIKLSEATPAVDNHLLHLWAARRSLESHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYK4</accession>
    <name>A0A9D4PYK4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_006407</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYK4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037055"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044872"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 16" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="701"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="659"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7961277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="803" mass="87487" checksum="27C35258E8C5BB12" modified="2023-05-03" version="1">MSRDGGEGQVLVEKVTLGSSSPVAFNSEGGFYATIYKAKLSVGTTGLPSQPASVFQAMGHKKGVKFTCVACHPTEASLATGDTLGRITIWQGLKETKPVRSIHHWHTLPVCDLAYTASGSFLLSGGGECVLVKWSLPSGGKQFLPRMGLPIRHIATSPDATLILTAHTDNCLRLVSSQMNVVRQVQGLALSQGSARELLFHDPRSSSLLLRGMPGHLQFYQPHEDKQLFCLDVVGQNYMTQEREGGIVNTEVVLAALADDWLVTVEHWADDSLGPETRLKFWHFDHTLQNFVLDTSVYAPHNGPLNDLQLHKPDTESSRGTFLALTTADDRKFRLWAPQDEVAVPDGPEPTSQGQVVHVSSWNCIGSGSFRGFAAGKGSISQDGSLLAVSFGRSATLWSEDCALRAALAHPQCPSSITELCFGRGASSHLLTTCTEVKLIVWDIICLTVLWELDCTVTCLVADISSEAVAAFCSNNSMLLFEPRIKDSVQTSDVPAECQPELYSWVDDTKEKEAVKANQSIKLESVVPPTPFGALVAQESRSAVATEAPEQHRLGLSGFREVRQRADEDLGNMFHPVRGGTRGGADQFNWEDVKDDKYRENYLGHSLRAPVGRWQKGKDLTWYAKEKQQAASTSRQSEVAAAKKAEEEAMLAALGFATPAKPTHQPLSKAEVTEALRRGDGSREEGDADRISGAMGDIPKGDPEKGKKIFVQRCAQCHTVEAGGKHKTGPNLHGLIGRKTGQSPGFSYTDANKSKGITWNKDTLFIYLEDPKKYIPGTKMVFAGLKKVQDRADLISYLEQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2H7</accession>
    <name>A0A9D4Q2H7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_013729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2H7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033190"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038605890" description="Serine carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="103674" checksum="0DA2D69F3347B502" modified="2023-05-03" version="1">MKFALLALCALCNGAHAWFGASMRRLYNGPDSVRRATSQLDDVGEPLFLTPLIEAGLLNEARYLSRVGSLGDVQDFPGHSGFLTVNKSCNSNLFFWFFPAKENPEKAPVVLWLQGGPGGSSLFGLFVEHGPYLVAKGGVPQLRDTTWAQRYSMLYIDNPVGAGFSFTQDDRGYARNEEDVGRDLHEALQQFFTLFDEYAANDFYATGESYAGKYVPAIAHAIDTAVAPRVKINLRGVAIGDGMVDPETMLDYADFLYQVGLADRRQADHIRSETTRAVIYIKEGRYMDAFLVLDKFINIDTLFQPSYFKNITGSDSHYNFLLSKNPEFFDYYQSFVDSPAVRKAIHVGNVTFSNGDATEKHLREDVMQSVKPWLASLMDKPQFKVLIYNGQLDIIIAYPLTDNFVSTIPWSGKEAFEKAERKIWKRTDGNGVAGYVRKVANFTQVLVRNAGHILPYDQPEVALDLITRFIDDKPFDAPDSVRRAETQLGDVGEPLFLTPLIEAGQLERARNLSRVGSLGAVPDFPGYSGFLTVNKQYGSNLFFWFFPAKENPEKAPVVLWLQGGPGGSSLFGLFVEHGPYLVAKGGVPELRDTTWAQRYSMLYIDNPVGAGFSFTQDDNGYARNEEDVGRDLHEALQQFFTLFDEYAANDFYASGESYAGKYVPAIAHAIDTAVSPRVKINLRGIAIGDGMIDPETMFDYADFLYQIGLVDRRQSDYIRAETARAVDYIKRGRYLDAFLIFDKLINGDTVSQPSYFKNVTGLDFYYNFLLSREPEGFGNYHAFVDSPAVRQAIHVGNLTFNNGDATENHLKEDIMQSVKPWLASLMDKPQYKVLIYNGQLDIIIAYPLTDNFVSSIPWSGKEAFDKAERKIWKRPDGNGVAGYVREVGNFTQLMVRNAGHILPYDQPDVALDLITRFIDGKPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3H9</accession>
    <name>A0A9D4Q3H9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_021011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3H9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053839"/>
    <dbReference type="OrthoDB" id="6499921at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="65"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="394" mass="43739" checksum="56D1FCE5120F4E7B" modified="2023-05-03" version="1">MAASLIDSIGSQDDFHNHTCILLNGKNITDIVDEEGLEDDIMGPRYHKRVRIAIIIIMIVTSVVGNSVVCWKLVLQRRHRRISKARVLFLNLAIADLLVACVTMTSQVVWEVMGRLWIAGDAFCRFFKFLQTFALVSSTYMLVTIAVDRHIAVTTPLAPSPDPWKLAAITWVASCMPSLPNVYVFHTVEAAPGQCFCASIFYERGTPLYHRQIYMAFVFIMVFIAPLVLLVTFYAGILWAIWKHSSASGKVGQQTTSTLPRAKVKTLKLTAVVFGAFLVTNVPYMVQEVILALGHPGILDANLVALFGVISASNSAINPYIFLYFEKRQLRNSHGFVGTLLKGLPCFGRRGASRHRGGSQQMVKLTVNYSSRHSRTVTTANYDSASCSEKTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4F3</accession>
    <name>A0A9D4Q4F3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4F3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029394"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037175"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="269" mass="30051" checksum="8FA5ACD1E3E4F385" modified="2023-05-03" version="1">MFNSLFVTGGSTLIPPYKSHLTHFVDTASHHSKTEYGIGIDHKKTRETHGLDKIFIVFFVIIVSISLCDLELCGKKAVKLSRDAIRIAVLKRNETFMSALVAEQATKTSLDEMWSHRVYHYGQVNTPPILTGFDTFQYVTQSAKGLQVRVISALKTLKKEWPNTTALAVSLGMGGRWYLPAFPDRDIDIPGNYTLGHHCKKASRGDAPPRPQISSIAECCEDPNYNETFSFDSIFQAMFAYDKSDYMLFTYDSAASFRLKVGSSAADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5A1</accession>
    <name>A0A9D4Q5A1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5A1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="236"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="314" mass="35290" checksum="1F8AC3A6C3DFE657" modified="2023-05-03" version="1">MSTDSPPLKKRKIRQCTFRKEWRSQPEYESWLLPVDDDATAARCTICASTFTVKFDGVSAVKHHASTQKHKQKSLASKQSATVKKFFVPAISSAEDHVTAAELGTIFHGIKHNYSYLSMDCGSKLAPKVFSDSDIASRMRLGRTKMEHLVKDVLAPYALECIVEKLRPAGRNLPFALSTDASNKGNRKLFPIAVRFYDVSGAGITDALIDFCEQADETSGGICELLATSLEKNLMEHVYSIPCSNAFVERVFSVMGNLWTDERNQLSVPMVKAELCVRYNLVYSCEEFVKMARENKKLIRAAKSNSKYIFKFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5U7</accession>
    <name>A0A9D4Q5U7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5U7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048663"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="448" mass="48054" checksum="0578902B1B92C2C0" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFWQLDACLAVNGVTAQPLMHEILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGPRPSHDHDQPFPATTSPTSRPATSASIPAPDHPPDEVQEVPAAIGHSNERSVFSTASAHSPSDLPAICTSSPTSTAHDTSDTSGFTTATSPHALEPGIDTDIVSPAVRPPIAEASPVMSNEPAFSTSTLCASCQQELPSSSKSSAAEVRAPNHQRPNLRDAATMTEASEDDLPGSTLAEQAAHVTPATSAGIQHPDLRTSPRVPPAEGASTRTSASSEPAATTPARCHRRFAPDTVTQDAAHPTCGHCAGERCRPPSHVYSSRTCRYFVSRHRQRARSVPSSHRHCCGRCNASPHAHPTFWDRFRHAENRALLLLPTASIPCDPRPLRSSQSRPPETHWSPMVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6F6</accession>
    <name>A0A9D4Q6F6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6F6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="75" mass="8241" checksum="74F1CCAD6D4E4EA2" modified="2023-05-03" version="1">MLRYVRQIDADEDDGPSNAHQSIRHSRERRFSQRPAAALDCVAPCSAVVNTCNGSDDAAAIKELNSLWNKSQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8G6</accession>
    <name>A0A9D4Q8G6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8G6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14885" checksum="24321E472F13B4F7" modified="2023-05-03" version="1">MVFATLVLPRGPNERLLRRNWRAVTRFNREAREFNSRLLDLCHAREGVFYVDHAIDRFPPWAVHAADGLHPSFAGVSLLAWNFYNLLLDLRRPYITDWQDNAPQPEAYGHGETPSYAQALQRDHPGDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8L8</accession>
    <name>A0A9D4Q8L8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8L8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038726"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF3">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="241" mass="25644" checksum="FB78EE6380553C71" modified="2023-05-03" version="1">MQTGEGTSCHYRFLTKGQQWIWLQTRYYITYHQWSSKPEFVVCTHTVMSYDEDLTHSKATPTSGVSAASYSRTSVPTRMSYQSSRVSSAPSVSSRDSLSPNLSEKSGCAGGVMRDERASSAGSCGNQLSLPFTEACTITRESPTMGRLVALASEPTSSSSSHLQHEPMDQRPSYQTTTACHAPLITLTTLQPIAATFAGSTQGGTATGASAAVQASERTAASATALLFMCMTSMQAKCACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q961</accession>
    <name>A0A9D4Q961_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) polymerase nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q961"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030763"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7971644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="268" mass="28881" checksum="D8EE1C5EAE3B5388" modified="2023-05-03" version="1">MSSFPAAGGRGDLLGGNGGGALQPQQQQMGSAMADKTLGMTSAISTAPPKPSDLQRTDELEETLRQFGLFESEEELAHRMDVLSKINQLVKKWIYEVSIKKNMPPSVAENVGGKIYTFGSYRLGVHTKGEFCRILMLSHPEGVREVSRCSQGARVAIAAIATDRERFVGGVHFSEIAETSEDGDDKRIDDAFHELSSLFPAAVPPEVSADDFEEAVFRLCGHRDPGCQADSSSGDEDRLDEAVATCAYSAAEVAAAFGSIHRFCGDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA87</accession>
    <name>A0A9D4QA87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA87"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="185" mass="21146" checksum="786FD25D83F9EA74" modified="2023-05-03" version="1">MSTPGRACCKASRPCRSIGGFQNGRVPSQAEALQQRCSWHAEEYVKVVERRGTLNLATRSRGQRETRGFMSWSDPLHQTPMLRSRSSRIEAQPSKKRRLRAWDNSQRVRRSRWFRERSGARATSVARGRQKADHTVGRFLREETDVQFAELERRPTEKLKMFRSAQSAGGKRQGADVVQTSGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QB66</accession>
    <name>A0A9D4QB66_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_023936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QB66"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031697"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="4">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7970047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17301" checksum="531D5AA97860E405" modified="2023-05-03" version="1">MLHFFLNQLSGDVEIVEGSKKALRVFGKVTIVQESPSMVVLEWNSSPVNDLFADAVITVVLRAQCSAVPAKSLPSTLVKVDRMHFTECLMETLAEMFGEDSVGKVVKGERMMVTVNDRCAHINLRSLEVQCEGDDVLQQIVSTAVTKLYNSMAPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBJ3</accession>
    <name>A0A9D4QBJ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBJ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048909"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21274" checksum="72B6F9C2945DEF8D" modified="2023-05-03" version="1">MDGAEELMPVALRDTLRGVRFADYVEVDTGASVCGALTDEDIIAQVAGAQLLLKSQKVRKTKMTKRLCARAMVVALGAGATGVFCTSNALWNLLHEAGSVTGDRVWRMPLFDLYHKQMTKTTVADINNISKQAGAGGSCVAAAFLKEFVKCPQWAHLDIAGVMENKDEVPYLGSGMAGRPVRTLVEFVERAAKLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBN6</accession>
    <name>A0A9D4QBN6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="5">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_000452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBN6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046427"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="213"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7975301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="428" mass="49839" checksum="2EA459765333ED4F" modified="2023-05-03" version="1">MRGCSFGAYCERRDLHVEASIYNEDDLLKAKLDLLQNTKMVDFNIDVYKMCYPDAEVPQDMIQRRGEVVQMLVVLKSETLALIEACQNDEVCKYIQSCRDSRQVMDYLMQNSNQINPEMIDSLYAYAKHQYETGGYTGAGECLYLHRFLISPNDKNYLNNLWGKLASEILMQNWDVALDDLSRLREYIDNNNFSSPLHSLQQRTWLIHWSLFVFFNHAKGRDLIIELFLGQPQYLNTIQTICPHILRYLTCAVITNKQKRNALRDLVKVIQQESYTYHDPITEFVECLFVNFDFDGAQQKLRECEVVLSNDFFLVACQDDFIENARLFIFETFCRIHECISINMLAEKLNMTPEAAEKWIVNLIRNAHLDAKIDSKLGHVVMGTQAVSPYQQLIDKTQALHFRSQQQIGHLEHRLSSSDRTSHWGAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCA1</accession>
    <name>A0A9D4QCA1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCA1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="251" mass="28205" checksum="EA53E6317841A86B" modified="2023-05-03" version="1">MKPLAQDMDYLAEVRQKFESEVVSRAPRHISYAFSTAYKRALADKISPTDNGSIIVSHSVVVSRGKTTNISSSVIIRNKKKTAYTPSAGNVSGVSTRRKGCTADVVRTKTTELVKSIDYGWVHQKRARREALDYNASDVNNTAATLKASHLDNDTKLILILLIALLLLALSSIMSYRPPMEHPYCIRLRPGAPPFYQPVPTSECWDAVEHKSNLGPRDKRFMSLVRTKILASRMVRRWRGRSDKQPLSFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDE8</accession>
    <name>A0A9D4QDE8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_003696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052513"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000028">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7975603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="36392" checksum="5D8025CFB9FEA0E0" modified="2023-05-03" version="1">MCVKTFFFATATFLLGMVFLVTMRLSLHDQRVTVDDYDLPPSLDGWKVQALCQGPPLDVLFFVHTASEHTSHRQFLRDTLGDPMVSEQLNSAMVFFVGQSKNLTVRRAIQEEARSVGDVVVFPFVDTYRNLTYKFVYGLKWANDNCRESVRFVVKIDDDALVNVFLLADYLKNITGPTAETSVHCLAWKRTPVVRNRRSKWYVTRQEYAARTYPTYCGGLGFILPVRTLPMLFNASRQASFLWIDDVYSTGILAKVAGVGHVQLRQYYDLFPNETAPTVRPRAMFTHLGTASIVEHRYRLWDDIMQMHNTSSRSEGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDW6</accession>
    <name>A0A9D4QDW6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDW6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027180"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="398" mass="44156" checksum="534A94C7DDFFFEF7" modified="2023-05-03" version="1">MAIRDNIGLTQDLIKRLTSYYGLALRSNTDVEDMKKALVQAPCSRGKPQPPHTYNLPNKVVEALWPVYQRLSDPQLQARCSGNKTQNAAESLHLVIWSLISKQQHASLFIVEVAVHEAVASSGERSNGPGNSGDEGKCSAVPEHRGTRTSSAPQGLSERPTAVEEKEPRGDPTPRYNLRPRAKKSQQATTSMPQNKTASVLLEEKRTVAAAGVSRLKGEHVASSSRRGRKRQRQQSPSSSSSVCFRTEEGPKLPPPISRDLWTTTGPKKLPKLDSRAENQALSNSAMSKEAPSTSCPSLKTSTVPMFERHGEEPFQPPKARRLSGRSCYMRKRHQTYERSKSSACTKKKCDDGENNVWNSSVVQQPAWRSLDQNPADTMRWKKLSPILLENRGKRECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGK2</accession>
    <name>A0A9D4QGK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_005089</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037420"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000483">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000167">
        <property type="entry name" value="Zinc finger protein 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF128">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="830"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7982452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="855" mass="92333" checksum="538B8DC863C0F201" modified="2023-05-03" version="1">MAASDPGSDVDVDGTEELDVGSESQPQEMLDASRLGAAPGGGAGTPSSWRSSSGSPEDELTSASLSPPPSLLAGGPASASCSDSELSFTIGVTEATPYACHFCDKAFPRLSYLKRHEQVHSDRMPFRCDFCQRLFKHKRSRDRHVKLHTGDRKYRCSQCEAAFSRSDHLKIHMKTHDHAKPFQCAMCNRGYNTAAALTSHMQNHRKSAAAAAATNGLEPSAALSRPGSSLASANGTNTLTAMGNPADGGSTSMSRDDSSSCSTDKLSLTGGSPGPGSVEVQTNGCKSISERAGSTSPRDGGEPLACGFCSRRDFSNLESLQAHVRASHVPFSAASLVGPSHGGQLRPEPRSASRQSPPAATTASSLVDASYECEYCGMKLPSVHALQTHTLAAHSFSEVLSKRMSAMMGADSGGGPLLCSQCGAASPDFESFRAHLASHLEGRMSRCCPECRAEFPSSQQLEAHVAAHFLATSVEYGCQACLKLFPRPDELQKHLLDVHAHHLYRCALCRDVFDSKVGVQVHFAVKHSNECQVFKCSACNAAYRSEPEFALHVQVTHLAKAAPYRCLLCDQTFASEPLLQSHLDTHGKQFACALCSQAFHVEFLLEKHMQACHAADLTLHPDGVQNLSVKSRIKDNRCDICDQAFGTDSLLAAHRKQVHNVRSSSQKSVSLLCAYCNEPCKSRSDLENHMKSHTASPSKHKCNICDEMCPSATTLAEHKLTHCKVVKGSTCAGCREVLRSEEQFLTHVNSHGGGPALPLPCVVCRQTLMSQVELRMHARFHVAHCDKGSLCCVCERPLDAASRIITGRQQERQSFMCKDCFHAKGVQDQGRCPECRIKFESPLELEQHVRSSHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGK4</accession>
    <name>A0A9D4QGK4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pogo transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGK4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036875"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25129" checksum="5F40ECBBCBC231A3" modified="2023-05-03" version="1">MKAPNVASVIGYGSAPKPIAEASYTVAKKIEVIRWHREDGKNVHQTSRHFKLDRKRIREWEKNFDNLLQLNYGKAKLRRKLCNCAPVFSEHVDNALFEYLERERSAGRAVSNRILSEEAVKIANSMQLGNFRNDDTLYNMANMDQTMVRIDNPANRTNNVVGESTIRIVNTGCARRGFTVCLAACATGHKLPAFIIFNEQSGKIPARASASVRIPGRVTPVNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHF7</accession>
    <name>A0A9D4QHF7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHF7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035643"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25315" checksum="331F999FD3692DEB" modified="2023-05-03" version="1">MCRNELLDLVSGLQSAMAEEQRRFDALGLQLQRLGAQGGDPEEQRALSAALCASQLRLARLCTRNMRCFAQVEAAFSSMMEDGSSSQEVLSTPFSAQEENHVDNDYDPKDFVVHRNTFITTEDYHSEDSTLPGSSPQPLVREASSDVSDDDEGDYHLPYDEDEEEMQQRGYDSRHHYAFYPEETELEVIPEEDEDHASNSDCSDPMGSLGTTERFLSERPRTSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHG7</accession>
    <name>A0A9D4QHG7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHG7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026874"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="471" mass="52052" checksum="72730CB0761B75B0" modified="2023-05-03" version="1">MQWLQLPPRVCDFVVSFLAHRTFCIRVGKERTGHFVTKRGVPQGSVLAPILFNIAQLPLAWQLASIPDAFFLLYADDLTVWTLHPDLQRQQHALQSALDKASDWCARIGLTLSATKTAFMSITNRRGRRRLLQTPICLSLNGQALSTVSTIRVLGVELDASGSASAWSQAVPAAAALAHYYNSTLPQPAAPLPEIPPWLKAQASDNRPLTRLRQSNRQAEQEAVVTTIDDSLAVYVDAAIDNCVLHTSLVCPTLPETQHTCSYVTEAPFPSVLAELTAIRDGLTLMIPKVDCLSLNRLLVYTDSTQAVRELRKVSSSLDIASDVHRLIYSCACPVRVLWTRRSTLAQMAADAACHPAEVQHPLPLLRFNQRSRGGEGSRSRSSMSASSRLSPERALLPQITTKRNASFPKLKKTSRRSLTKLNKVHEAARHQLARREKSRRCRALNFWSPLWASRARALRRPSSSNPGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHN1</accession>
    <name>A0A9D4QHN1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHN1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="83" mass="8498" checksum="1740F6BEBC8C9A5E" modified="2023-05-03" version="1">MFLEVLRLDVQLLGGYHHPGTLAGNLAGKQTGMFGETAGKLGGSEAPDDQGPAAQCGAELGIHGALEEVMLGHWLGEAALLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QI83</accession>
    <name>A0A9D4QI83_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QI83"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47013" checksum="DAF1006E56047217" modified="2023-05-03" version="1">MAYKVSGMDLPATEFNPEEWSVVLNAPTRSPRQQSKETEGTQSSSAASADGTQASKTELAPSVPSTLDDTAVTRLRSKRLPRLPVDDFKIVFRPSAGVNLAQYNDGELRAAVVANSGLHSAVAEEDLVCTNLSKNIFTVSTSCADRVANYAKIRELTLRGNKLAFHAYIAPPDGARPGIIYRAWNGESPQDLLRELRRANPLLPIVQARDMGRTSRSVLIHFMAEELPPSVKMFGILYAVFNFRPKVEACLNCRQVGHRRDVCPLPNRLTCSSCGQKHPEDRPCTPQCLICGDAHMTGDRACKQRFQRGYSRPSRPRQRPQQEQEQHEFKLEKESFPSIQDGNRGSRSKSPGRKSGSKGKSPGRSSSQSRDLDTKSGKVSWVEQTSCSCGTSFDSKEKSKTQETIERLIRENKELKQQWLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM24</accession>
    <name>A0A9D4SM24_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM24"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028171"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042715"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7934878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="44864" checksum="DF2033208ACFBCCD" modified="2023-05-03" version="1">MAFAAPPPKAHCFTFSAPEGSTVDDVIDALEVVTGSAGIKSLQHMGGVKFGAAAANVHAATKLKIRGAILLNGVSVPLVSVGPEIVHVTVFRVPLWVGDAALATALSAYGTVQHVHEPVFKGRPGVGTGVRVTRVEMKKPIPNFLTVQGYNVMCDYRGVQRVCSKFRNAGHIAKDCSTPRCARCNVFGHATEGCTEPCRKCSGSHATADCIRPKSFAAAAAAAADEQEGNDLTPPAPAPQEELPALETESDTDTPGTESHAESQDAGDLPPPPENVSSTTGAPAETSDSSPDAYEDHSASKAEAPVSGASTDHESCSSDTGGTTSSSEAPRTSMGRGTRATGRAEAPITCPDKTTTMIMPPTVTSTRACKYSAQTRKLSLSNPLHKITGSAAVMSDGASAMKIERQATKRAHPPTTDSEGSTDSSKPKNSLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM79</accession>
    <name>A0A9D4SM79_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM79"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049537"/>
    <dbReference type="OMA" id="VYIGANW"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="16038" checksum="D545E00889D4ABB0" modified="2023-05-03" version="1">MDLFRGKTLLKKDGTTMSADGALRNKRLICIYFAAQWCPPCRVFTPLLARAYRKAKDEGLPIEVVFVSSDRNVNDMTAYVKSDHEDWPSLPYGDALQAGLRARYKVAGIPTLVVVKADGALVSANGRPDVQTKGSRAFKDWLSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM85</accession>
    <name>A0A9D4SM85_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM85"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030149"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="612" mass="70219" checksum="8987ACAB4EB20FF6" modified="2023-05-03" version="1">MEYAVEGEYLRDREAPDSEQGPWAALPDVLLETVYSMVPIADRYAMSQVCRNWYRVFYSPRVWSVFVLDDRTMTRRKFNYYMGYQHLLDHYRTQICVHKIGRHIRHLLIPAMSNFFNLYEFMVIMAYFGERNNALGHLRRFEFTFGCHLLGNNSDGQRPQDSVFGTGGKLLESLKRLMCCFTGLRHLALTDLLLEPHEAKFLLDDVAETCMTTLRTLRLVNCSKEPYPFLHAGVFLNLTALYISPQHLDDDLVTLLSYTSLRDLHLIQTTYTEMGLRVAPRVWRECRRAAPRLRVHLSVEGTVAKEIIWQDCAPVHSIIYKTAYNQVGPESALTAATYYAEDLRTYAFLGLPRFHMAKRFVDRPDSALVLLCRSCRRLETLVIRERISTATVLLLAYHGRSLRRFVVRGNAVIKKCDWPRNPEWSDEFYAWLRHTAQSYDAVCQEVSQILGFAWAPLTDKQFKTIVLHESGSRDFFPVSPQSSMGDFRFPAAEHRLSFSSSGNVYRSMAKRFEFSCRSPKDALSMSEQLPSEHCSGALEAPCFFSQFRHGDAGPPPHRDSGRFSFGHERGTRCVGVHVPLTQSSATFSSSLDAFSLTPRPVFTFTSMILTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP29</accession>
    <name>A0A9D4SP29_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_000172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP29"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057011"/>
    <dbReference type="OMA" id="FFMHGLF"/>
    <dbReference type="OrthoDB" id="6475813at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="89"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7938753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="415" mass="47320" checksum="5F40C1E756B7FD30" modified="2023-05-03" version="1">MVSPGEAVSRLIPSLLLGTVRTALDFPSELANFYTGSDPDRCTGIEQLIRSKGYPFERHNAITSDGYIIEMHRIPHGLEDCKEPCHRQPILLMSGLLGDSSNFVLDFPKQSIGYVLADNKYDVWMGNVRGNTYGKRHRKYNKRSKRFWNFSFHEHSKYDLPAQIEYILKKTGRKDLLYLGVSQGTLLFFTMMSERPQYNEKVKAFAGLAPFNKLSHMNVDSLAMLMPFADQGLRMAYALGTYEIMPRGFPLLLPLARSFCALPTRAICSLLGDEFGNLGSKYMNMSRIPVYLCHVPAGTSLKNIVHYSQLVKSKKATKFDYGPLDNKIYYGQEEPPEYQISNVMTDVGLFWSRGDQIVPPANVRELIEDLGPWVKKNHFIDDPYYTHVHFAMALNNPTKLYKDLLQFLDKYATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPA4</accession>
    <name>A0A9D4SPA4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPA4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025832"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="149"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="513" mass="57007" checksum="35836D4DA7ED04C5" modified="2023-05-03" version="1">MTTSPERRFLDRDDATPPEERICAQLWALAAALMLPLLLSSWLLFIPFLIWSKNTVVTEAPVTPLAKTRSVSITTLTSSPTTAHTTAAFSWQGMPAHCLLPVFPPTEPSSYNIGPYPTRGADHDRSQRPIFCLFDNAKVTIAGASQQTSDYMFETLPFALCPNVVYASVGIADGHLVTRLPRFEQNHGLPQLRQIVNTRGFRDTRILLVLGGREEDAPHFWRLGRDRSTLELLMRNVVDGMRNYELDGVTVHWKAPTSDCSGTDHDMVLSILLRRLHETFAKYGLTQHIVSVMLEMNASNEYFLNSVANVVNYFFIGTNALRYTGPAPYQDICANLSRAVRLVIGSYATVGRQVRMDQLCIVEELAPWTALGFERPNGFWLSGGTGLSRVPLYSACSGTDFCRKDAGGASCIAHLKYPGLETSATRTAAIFLVPNTNTIRQLNFSGINSSAPSTTVHACVLVLDLHRDNYARQCGQYLQYVLMEHFYNGLIGQRRRSHSIIDAAPLCRVPQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPA6</accession>
    <name>A0A9D4SPA6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPA6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="64" mass="7434" checksum="7A3743B255A07382" modified="2023-05-03" version="1">MSEAEVRHSIDAAENRRQERYLTLTGVVRRSVHCLPADATQFDALNSDCWRAIARYLTLWHIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPU3</accession>
    <name>A0A9D4SPU3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPU3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="378" mass="39595" checksum="1DAD6CF4E842338F" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWLMQLDACLAVNGVTAKPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPRTREFRVSPPPTRAVPPGLQPSHDRDLPSPATSLSTSRPATSAEVPAPDDPPDDVQDPTPEVPAPDDVAAAIDQSATSRVSSTPSADGPSGMPAIRPSSLSSPALDTSLTSASTLAALPHDLEADTDNLSPGVRPSLAEVSPSTIPERDLPSTSELCVSCQQRSASPSTSPAAAVRGPHQLRPNMRDAATMTVSPEDDMPVSSKAAPHANVTPATTADVQYSDLRTGPHVPSTIDASPSAAAPSEPAETTLARLHRGFLPELLTHDAAHTTSEHHPEPPARDPMVPESPSPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ46</accession>
    <name>A0A9D4SQ46_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ46"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="228" mass="24275" checksum="DFEBA0C0BA2406F0" modified="2023-05-03" version="1">MPRGTGVLLGCADNAKTNIACTASLLLPASKATKATVDDFRYCLAPCGESCFVGLLTRGEDHVVLVAHAKETLDFCIQVDDYGNVVQSFVRQPSTRTMVVLYDAHALESTPSFRESGVNALVGWLLKCQGFRLPEGVVVGCVVVGCADVLYASADAEEISFLWQPAICAGSLIQAAKTAIKRKLPTRTTSMLSTCAQATSTGALICKRLDDFAAVADSVRTHGRITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQJ4</accession>
    <name>A0A9D4SQJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034943"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="69" mass="7595" checksum="9A4D7EF63A3A0BC1" modified="2023-05-03" version="1">MDQWGQDSYEIMYGKDMIAESTLTNFQSYVEGRLRDFVGADAVMLVTGFGDEDGISDGISDETEDGISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS59</accession>
    <name>A0A9D4SS59_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS59"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="11368" checksum="6773F267343F0D1B" modified="2023-05-03" version="1">MAHVAGLEVAHAAVFGATGSDGTESRAEVKKTNWLPGDTRALSPEMVFFLVYCHSTCESRQNGGGGSDQHAVRCSNVLKRVASFGRAFGCPAGSPMTSAVPKCSFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSB3</accession>
    <name>A0A9D4SSB3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSB3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054016"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="78694" checksum="A6776656DCAE6406" modified="2023-05-03" version="1">MLFLKSHSSGSLMNYRTLCTSSEDRLCSVFADLPLWNEIFWQVGLELRELSPGQLSLVERRCADVSTFLSYTVEKSEAATLLCHLLSHHHCFVSVHLNHYVFRHHHKLICDALLKSPGLTKLTFCGKLTNASQSFAAALPHLKHLQELQLSYVPFNRTSLEGLSELLASTRSLTTLTMSDQIFEGDEAVVVLRGLGQNVTISTLSLHISLLNTVSPQCGDIFADYLRCNQTLLSLTLTSSSCLIIYDLRPIVGALFCNNILSELKLIEFALDRRSNMIITDMLSRNRGLKRFHMDCCIFYGNDCDMNTPVPIFWSGSSLIPYWLAALAENNTLEELTMGVSWVKPQNCSSFFRALACHTSLKKVNVQTCDQYDVVQICRVIRDTGAPERFVLRQLIVSNETATVIPECKEVSRISQYWHNGDEVALLRTILPLLPACSHVKSVVLQMTGSTFNGEVSSLIEQYLTDTTALRKLRLEIDSENLRSVDLSEQKLLQALSKNKSIRKLSLKGLCISEGEARMLVDKLESSRTLCRLYLYPYNCEASTWFVQMLSPNVSSNYMLLSMRTCWTGRLCGGWFPIKDVVRRNNSLVTRAAHFVMGTRHKYCAAAAELMQHNHELVVKVQELASVDENEAVSRIEDSLKSFTELDDFMRLAGVVECFVTCHRRDDGQKQLVDLNPYCWLHIRQFLKVGDIPDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSG9</accession>
    <name>A0A9D4SSG9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSG9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="151" mass="16106" checksum="72B2F8A3956B9A2B" modified="2023-05-03" version="1">MRLGRATHAASSSRQHGDVARVSEQRRSWPRLKNSPGGTLNSIRRGSQVEDEHRGVAQARGRHPGVDPVGRTARDETRAKDGRPVTGAEARPSSGGHDDGEAGTEPELHALSSSSSSVFAASPFFLLARAAFFVARAPRAPFFIGPARRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSJ0</accession>
    <name>A0A9D4SSJ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSJ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048384"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7943871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="22885" checksum="F0D6520F5A24CA23" modified="2023-05-03" version="1">MPKSYCVVARCPSREVSDVAYHKFPVDSHQRQQWIDFVRSSGRGLTWTPRVSSRVCSRHFASSCYRHDPVRLAQLGFSAKGLLLVPGALPTVYLGADPRPAWAAASAAEPSLAKRPRHECAVSMTTKATMASLSKSTNTRTVCLQTGRITEEVGPAKADASTQCAVRMTLKATQVSVNPRGSRTVAVQTMTSMATEPSSGCASTHCGVMYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST52</accession>
    <name>A0A9D4ST52_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST52"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="12907" checksum="6FFBF28237DB62A9" modified="2023-05-03" version="1">MKAPWTYWSGICSSWPAAPSSIHSHQPRRGEGSSHVFCTPRPFIGIPVTPSGARTAENRAVSGGGRGVVAGADVMPAGTEALPVQCPSNALRTFVVESAEHVSAGQYAEVVVEIVEARDCQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STR2</accession>
    <name>A0A9D4STR2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STR2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="21081" checksum="302DB9F5D37EEE3B" modified="2023-05-03" version="1">MLPSLCPPVKPFHPAYARAWFMQLDAILAQNGITAQPMMHAVLLQALPVELHHLAAATTSSPQPYDDLCAAVLAPYGETYRPLPGTREFRVSPPSTRAVPPGPQLSHDHDLPFPAMTPPTSRQATCASIPAADHPPDEVQEVPAAIGHSTETSVFSTASAHGPSDVPAICTSSATSMAHDTAATSGSTTATSPHALESCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX85</accession>
    <name>A0A9D4SX85_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX85"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.30">
        <property type="entry name" value="Bcr-Abl oncoprotein oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036481">
        <property type="entry name" value="Bcr-Abl_oncoprot_oligo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="463" mass="49433" checksum="9B0900B04A13FC46" modified="2023-05-03" version="1">MEAFNDLQRHWAKRFPHSKLSLIWEEDLRTLLSTHRQRVAQLREELEQEEFLVQYFERYLSDAERVKRSSSRDNTGDRKAGSENGDSSRNSNGVVGTSNGLPEAAAAALTSSTCEKAASLKREKDSNSAEGLAASVNGTTDEHGKPYVTVIAVSGFTRSASSERSSAAAASTGPTATTQAAVAETQEVRRRRKPPTPPPKRAKWPPPSAVSQLAQNDAVVASDSAEPVATVASPSNDGPSQSEPAVAKAQNDATPAFSTFRPASTQLTSSRPHGYPQPQRAAPPPPTAPVIETTDDQDGYDVIYDTVALDDEACSSKEEEDQGSSPEPDYVEFGKLETTRPRAARSDDTGSAPSPVVPSPATYENMALLVKASESMDSEEDDAASMLRSMSSDAELDQDAGTATTGSDHSGSGGRSADLHRCKTEEQLDVDSGEFGDPSARRPDLFQQAIRDRCLLAADVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXB7</accession>
    <name>A0A9D4SXB7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54243" checksum="B278AED303A0292F" modified="2023-05-03" version="1">MQDFAMFLQSVDLPKPGGITAASVALLWPVAPSGGARSGHRKKDPLSGADHGGPGTSVFWGYSKDSPKGKQLKEALEDAGFTLLNTPDQYTRIGGVKQNNTSPDLTWVRHLPQGLPKYAKLEDLYGTGLLLPIGDYVEPALQAQNERLKLTRAGRAIRSELGLSNEDLPQILPTIPPWEDITVTDNRPLPKHMNQASDTQRRDYYAQRHIEYLKTISDEEEIIYTDASCTLEGSNTGAFLNLRTGEASSFSITHSCLLPEAAEGHAISEALAHYTQTESSPKAIHIFTDSQQVIRTLQTRSKLPEYARHILNYAAQLQERSIRQTATLIQGDTHDANYRAKVHRRRRLRAKLEEATKHDAPPPRSTRPYEVILRRLQTRSFTTIPVLHKMYPTKYPDPNCDYCQAPATTEHILWECPLHESSRAAFIKRAQRTLPHLQQDMEETTHWILEDPLIRARLNIWCNDLRKTAIPCPAITSTTSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T088</accession>
    <name>A0A9D4T088_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T088"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044438"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="374" mass="42414" checksum="F64623308C640B95" modified="2023-05-03" version="1">MEPPVDPDWQWVGCNRTGDSRKGGGVGVLWRSNAAWVPMKGTCDEHIWVTGSILGESALFGVVYLTVTSGPHDGNDKVLQCIVEDVKRWGTDREVLLMGDFNGHIPATDGYLDYNGELLLRCAEQLSLEIVNLRNDCEGCFTWCARSSRSTIDYALVTAKLAARIAQVHIDEDGQFSLGSDHNRIRLSFSKGGFRTGCRSPPPRRGMYLPSKSVERVAEDFENCPQRRKSHTYSEFVGALDSVMRTLMVQERRRGHRPQNPWWDREVEVAWKERRQANREHRRTVIGPDTEVCAEKWAVYLDQKHKVQALVQCKIADYNLRLIQSIRQEGRSAAHKFWTYVRSLDRAAPPPPPLVDAATGQPVTEPPDYDHPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0D7</accession>
    <name>A0A9D4T0D7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0D7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="700" mass="74930" checksum="1A4C124A26B3C838" modified="2023-05-03" version="1">MASSRSAQCRTAVSSCEDDPTKVVPSASAPLDGDTSSTVASEPSSELTADEKSEQYDSFDEPRFWSALPRRGLRPLLSRSIAIRLRPSPSLFQRGTRARSRVWGKGKPQREGVRTKGPWLAHAPRGAVLVRGKERVLACVCGRGVVAAEEPLGPLVLCGRCESALRAGDGTRRCADLTDMDGGAGGSGGGGSVPPPGARAPADYYQLLSGRIEGAVDAFMDRLGGRLSELEVELRYAWRAVDLLSQEYVKMWEKLERLEVLLFEQQAVIGQLMGLIHGEQGAVEPIAEDVVLQLERRLREEVGAEAGPEPMSPREAVFLRRTVLEAVPEVVSSQEEATSEEGSCSCENEESDSASVFTASDYRKYRGAAGGSLVSDRDLCELGRLSEDLGRASALARVEEEEDPEEDVGVKEDRRARQLARLREASQELALAVQKNLVSASVLAPEIPPSPPPGGREVGMAVGAFISDTSSEASTQLVPSVIEAQVHNESPQPATVEPAAATKPEPEVRPERRKTTGMSFPSPRKQRVKARERRHTTAAVPPSTVAAATELLPDVCPKRTLSDVTVSSAEQQTPSSSAHSPFGAGPGSLLTNLGSKLSMGYTKVMSSSLLKRDGSKEKAQRSRARRLSLLRSQSVQSGSEPAPNEPQPPLVVQMSLPEMTTTPPVTPKPEHPEPLPDSPSRETGPVVGSFSHTGTLGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0W6</accession>
    <name>A0A9D4T0W6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0W6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46486">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46486:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15034" checksum="6E7D6AB941B38D08" modified="2023-05-03" version="1">MGPPFTFVNVYRFPAYIPDEILTNALSQYGKMKSVTFATVASRQNKLNGVRVVKMEMCRPVPNFTTIAGHRVMCEYRGTRRVCARYGDVGHMATACSAEYCKGCGTFGHDTVGCEAECKRCGGRHGTKECFRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T106</accession>
    <name>A0A9D4T106_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T106"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027945"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="693" mass="72725" checksum="EAA7944FA8A52E47" modified="2023-05-03" version="1">MVQTVLLAVTCRGWRDPSVWGGREAVAGFSSSDMERGKPSVITATLNAPSLHGEETSMVRIISGTLATKTSGAPRVLLGAPCCDSSFPASSSHFIINKRPAQAATGGACTVSDREFDWGSLTRSTSARASSRTPAVSPPAKGQQKDLRGSGGSHHTAGPTMAASRAEHEVSPSGAGPPSPGGSPAVSDLSFSPEGDNILAGLTGQAENGPAETAEAAVRVEPTTGSAHTRSSSRSTTPAVTSADEDDAGRTDHGAQAQARARELEDQLSRFCADSANCITVSVRNFILTRVFELVGLCSDLRADAAVERGAALALQGQLVEARREIAGQQRQALEGSPLRHVDLPAVTGPDNDVPLGARPALQGPAGGLIYAAVLRPGPLAGVQAPGRPGFPATSAGPGMVAAPAGARHEHVAFPTPTGTSDTPARDVVRTLKANIDPVAKDIRDVTLRYTRYGVTVFTNTRQSLLNMRTAIEQNAVTRAAMTIRVPEKRNPYVRFSGVDPEIGPDEFLRLLNDRNPNLQLDLERSKVCVTFRERGGTRAFVVEVDPAAFHRIMACPRLYIGWTIVRAYEDLHISTCTYCASYGHGRSSYPVASDPSKSVCMRCGAEGHLGAACTVRAGDPSVCCAPCRCAGWEASGHPAGHPECPLLLDKVARLRARTNYGGAAGDTGGSHASFVCTAEPRPFEVVVRKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T160</accession>
    <name>A0A9D4T160_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_001512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T160"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044803"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="795"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7967635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="935" mass="104391" checksum="AAD7858AD843BBE7" modified="2023-05-03" version="1">MLRMAQSDVLVCGMGALGVEIAKNIILGGVKSVTVHDRAVCTRLDLSSQYYLSEESLGENRAAASEASLARLNQYVRVEAHTEPLSKEFLKQFSAVVLTETPLDEQEEIAAFAHENNISLIVADTRGLAGQIFCDFGEKFRVLDPNGEEPLSVLIASITKDTEGVVTCLEALRHGFEDGDYVAFSEVKGMTEINNCPPMKVKVLGPDTFSVGDTTQFGDYVIGGVATQVKMPKDIKFKAFQESMAKPDFVVSDFAKMSRPPQLHLGFQALQEFQHVHSRLPRPWNKACSGKFGPIQQWFYFDAFECLPQDADVSETSANAMEHTRYAGQARVFGSDVQDLLMAQNYFVVGAGAIGCELLKNFAMMGLGANDGLIHVTDMDVIERSNLNRQFLFRPDDVGQMKSTTAARAVLEMNPELNIAVHENRVGPETENVYNDDFFESLDGVANALDNVNARQYTDKRCVYYRKPLLESGTMGTKGNVQVVKPDMTESYSSSHDPPEKSIPVCTIKHFPNNIEHTLQWARDEFEGLFKQAAANAVQYLNDPEFLPKMTRSLPLSQQVVTLEEVKKILLDQRATVFDDCVVFARLRFQDQYDNQIRLLLRNYPENHTTSSGAPFWSGFKRCPHPIEFNPNNALHMDYIVAAANLRATMFGIPRITDREAIAEMLKVVEVPAFDPLPNANVAAGNTTVAVAQSDSDRVNQLLEELPDQSELGDVELTTLEFEKDDDTNFHVDFIVAASNLRAANYNIQPADRLKSKLIAGKIIPAIATTTSLVAGLACLELYKLAQGHKKLELYKNGFVNLALPFFGFSEPIPPAKKNFHGQEYTLWTAIDIQGEITLEKFIERFKEDFEVDIIILSEGPRMLYANFQPPSTRRLKMTMSEVLEDVSKQKIDPGKRSLEFAMICTDFDGNEAQHKLPTPFLPRHQEACDAWSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1Z3</accession>
    <name>A0A9D4T1Z3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_009547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1Z3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048880"/>
    <dbReference type="OMA" id="MTPTMGW"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038986513" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="422" mass="47036" checksum="31CD63E865174FB4" modified="2023-05-03" version="1">MATNGVVLLCASLLAAAGVNSLDNGLARTPPMGWLTWSRFMCNECALGLHENCLTSELILQMADRMVEDGYLAAGYEYLIIDDCWSHADRDVHGKLFADPKRFPEGMKNLTEEVHQKGLKFGIYADIGVKTCGGFPGSYGYYTTDAQTFADWGVDYVKVDGCNANPRDLDTLYPEMGRALLATGRDMVYSCEWPFYQIIAGILPDYKNISKNCNLWRNYFDINYTWESITNIINFEATVQDIVANVSGPGAWTDPDMLVIGNFGLTIELQRAHMAYWAIMAAPLIMSNDLRHISRESRDLLLNKYIIAINQDPLGLMGRRVHKGKDLDIWARWVTPELADGKLSLAVLVYNTKNLGGPVQTFVTLQSLNLDSPTGYLVTDLIRNNTVVGKFYPEQSINVTVAPMDVFFFKATALSGMHDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3H4</accession>
    <name>A0A9D4T3H4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3H4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34753" checksum="FDA108B3D6848722" modified="2023-05-03" version="1">MPTTRTECRQKGEEDEEEDYAGGLKPVFSAGNSAGSIAEPQLPGSTLLYSTQSHRNQKLKVHSEKPRPPQCSVPFLHPTCCVAVGGGGRRQGSVSISAASIWWGCLLCVQCLLFVLLPLIAAFGLALTLLFAKEAPLVHATLPGTTDVPTEEILADYPVSDAPSKTTTRPTGHPRAEMVIGCKDCDPRWPLSGRLVWRTAPGQRSSTGGGGNDESVFWDFPDIAMDLHGTWTLCPRLYVLVPTAPERRAQRKAIRATWGRLYQYPSCTLRVVFFLRLPHGREELAAIKAATGFPKMEEVVIHIRMTVRELYCSLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3M5</accession>
    <name>A0A9D4T3M5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3M5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050550"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="607"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="801" mass="88882" checksum="9574594B4A1B7ADE" modified="2023-05-03" version="1">MNVKGSRPMHRSVSMEHLSTVKPFSIEKESRSETENAAGRCATATLTPEILTTGLTSNLTITSSPSEQPTDILTGERMDEDAASNFHDDQTDDEEAGGCRKTVMNKRRARKMKAQKETESSENIPGVSQCNIGKHCGNQHLPRLPLHDEKIILRPHGGLCLDKWTRPELAGALWSAACLTTKDRQDIIFRLRPQRNLAIISTRQSHVSDAVYKVRELRLAPENSCKGVVPGIVPGTSSSTLVDELVAPETQIFQACMMGQTNIALVTFEGLKNCVATPIVPANWFVSYATSSAIGMAIAVHHTWSHARRAALITLPHCIRALHTANRSDGAHTTTDANCPRRERQAVNKVWVEKPSRNSCANSSTSLTLPLQTSQLRPDNPAPAPPPTKKKEPLRWKSKKRPPSLSSQQPYKKALQSEAYGKEVHAPSEKQRALEQNTTKAAAPREAHCERLQKQMDALVADMGASMQAALDRIERPMETLQIEITEQVHGAPSPTHALPFPLSMNMAPCDALPLVVWQWNCKGFRQKRSSLQQYVATSTNPHDVILLQEPKCTPSLSGYNTLLGSSPLVGALVSKHVTSGVPATSSEIPHQIIEIITQGSHSRSLFIFNVYSCPRSRTHCFHRLITEFGNCGRVYVVCGDFNAPHPVWAYVQPQAKETRLWNGICSMRYTLLTDPERPTRTGNSRSRDTCPDLTFVRNTGPVVAHGPLEGHLGSDHYIVATILPLHGVGRPELKLRITDWLKFRERRREPPEGQAYELWLHSVTEDLEATTRTLSTTNESPDIDPHLLHLWDARRGLTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T438</accession>
    <name>A0A9D4T438_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T438"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050837"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="478" mass="52268" checksum="CEB16D3AD19EE448" modified="2023-05-03" version="1">MLPQLCPPVPPFHPIYPRAWFMRLDAILAVNGIKAQPMMHAVLLNALPVELCHLAAKPSSSPRPYDDLCAAVLACYGQTYRPLPGSRELQISPPSQGAGPIGPEPSLDQDFTSPATTPPTSRPATSASIPAPDHPPDEVQEVPAAIGHSTERSVFSTALAHGPSDSICTSSPTSTVHDTSDTSGSTTATSPHALEPGIDTDIVTPAVRPPIAEASPVMSNKPAFSTSTLCASCQQELPSSSKSPAADVQAHNQLRPNVRDAATMTENPEDHPPCLPQVDQTAYALPATQAYNPPAAPHSRSPSPTKLHSATTAAPSTSLSSTAHHTEISRATSICSARLAARLHSTRQTMEQPHPVMYHRQRRYRHRRRINCVARPSRLRSCPRTSKPAGPDVLHLGSTLFLTYLRPSVRKNRQHHNRLCVCRFRWAAPRNFSAHYRFPRYRCRSLLPTASLRRDPRPLRFSQSRQPETQWFPTVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4L4</accession>
    <name>A0A9D4T4L4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4L4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029038"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21697" checksum="5AFC43A0BBFFD061" modified="2023-05-03" version="1">MEGEPPGGGRPHHCVFKPRQVNSTSAAQVFTAIGSNTEYLRELIRSVVREELQKAAAPPLPTVSSIASIIKDELHQALRDPVTLDNTTAVPTEYRRATYAEALKRPASSPPLFVRAPPTVSLQSAQQLQYSEDTRTSPFVYGVEIYAGEIIAGVAFSLRHAGERRWKLPCGSSSIIESFFFTSTLHVTQARTSPLSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4S6</accession>
    <name>A0A9D4T4S6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4S6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026033"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="172"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="308" mass="32290" checksum="52911DC2A20EC881" modified="2023-05-03" version="1">MSVAKSLNVQLRRTCCRWWLRSASDDAKKVVLDERRRSRQALLRVRLPCSAAISAVDDGSAVVTATLMGARPFLGCESPIALSLDGAALTVTGVDGTVADLLCRLRVPFMTSIDVELSGCAQATLENLVLDQCTVRTEGQGDIALSNVKANAVVLTVEDGSITAKGAVQGNLEVTSQGSGGFKAQRLLANHLKVKTLAGQQHLSAVYAEKARLESTEGIIDIGTLHSQDAVLTSQSGAILLGNVTLSLSAPCKVTVDAPVKKSDFDGLSEGDVHSATESQITAKSCSGSVIVKKQDWISSLNLGGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5F3</accession>
    <name>A0A9D4T5F3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5F3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="25636" checksum="FC2F213A4E0BD800" modified="2023-05-03" version="1">MLTVPLPWKLKSGSPPGNAALHEESPEALWGPPTTSGKRRLYWGSATSALKEFSYTGNAVAATAAYKDEVADALDRGHCRCSDSELMRLLRQHGQLPPLLPAQAPNAAQPDHEGAMPGKHTSPFTDRFRYVGSEELDHFMHGTEEQLFAGLVRNPSTSVNDFLNGVIAIKHPLHLRYSQYHCLNSGGLIDTIAVTAVTATDESSLCQLIRAVVQEEVKKLTTTSNECAITSDTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5K4</accession>
    <name>A0A9D4T5K4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5K4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028902"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22290" checksum="17CBD1D9BF6C5DCA" modified="2023-05-03" version="1">MWESVVLSPSVAHILATLPQRRAISCDDIVSSFSALPLSGPLQLRQFVQPRHNLTWSCPQLISSARTTGSMQQWRHRVHGFGSHVEMKTVEFVEKLERWQTVCLKCGDTVAHKDMRLHYPGCGGRPGAFLRSAEARCLLDNLSAACEKLEQAVASAGPYESATLRDTVNLVREQFTRIRGQLAAGVPWHLKNCCLLRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5W9</accession>
    <name>A0A9D4T5W9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5W9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054540"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF4">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64573" checksum="B140B11750C86D38" modified="2023-05-03" version="1">MMVCFRPELGQHDSRSTPLPQSEGALYFCLDCDTNQCEGCELVLHEQSRFRDHRPRVPVVKPEPHLLCEGFSCRGENLADIRCHTCERSLCYACDYQIHLLRRRFAHVKVRFRYYLERQAKLAAAEVAIDDEEEQYLSAEPYCSLPYEDTGTAMMEPTSHEPDVVSDTRSGCKSLPTHSSILLVDDKEVLQVSSGAELAAQLGCSSDTSVKVVSIFGNTGEGKSHTLNHTFYNGQRVFQTSPQQESCTIGVWAAHCPEHGLLTIDTEGLLGVAENQNQRTRLLLKVLAVSDIVIYRTRAERLTTDLFTFLGDASQAYVSHFAHELKALKERGKLDKPISALGPAVIVFHETMYTEPLAGGEGAKSAVEELKKRFGDSKRSIDAFSDLQYVGIQTVGLPTCFDGLRATVKKVMDNSTVRSARPVEFIFQALKHLNEKFNGDIDSSVPSTFPDQYFTCPVSCLSCNARCNKAMNHQDDHCGSTRCHYQSHLDNRVQQCKNCYEKFGREVVLTPQTGAKNDSTVTALAKFAWSGYVFECPSCGVIYQSRKYWFGNRDPEETVTRVEIVHVWPVVSIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T615</accession>
    <name>A0A9D4T615_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_021479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T615"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029382"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7976902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="71" mass="7808" checksum="96AB46722F60A251" modified="2023-05-03" version="1">MTDKKQIPCELNNLKGGSDDEGAAEDAPHMPDRGQWTGKLDFLMSCVGYAIGLGNVWRFPYLCYKNGGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7D2</accession>
    <name>A0A9D4T7D2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7D2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029504"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="29107" checksum="68AF56518DA5D5C6" modified="2023-05-03" version="1">MDLTDFPKDEHTCKIRFSSLAYSNDMQEYDTVADLAENALTATDPWQDHQWEVTVLPMWGSGELLNRTYLELTFRIRRRSSEYLFSVTLPWLSSVVLMLLVFWLPANSSRRLTLCCINMLLLALMLRRMVPLLGDSYRPPKIIFFLEGAMLLQALVVAIAVAFLNVTSAHVLFPVAVPASVIHFLTGSAGMALCLRHHDMTRHGAAHTAPAVGTDELSLQKPVTRLSEERAREWLLVAHALDRLFVAVFLVAAVCVMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T836</accession>
    <name>A0A9D4T836_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_024089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T836"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051777"/>
    <dbReference type="OMA" id="RICKSPM"/>
    <dbReference type="OrthoDB" id="6490900at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="301"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7977068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="464" mass="51108" checksum="B575FDA2E485FFEC" modified="2023-05-03" version="1">MGTGFERGDKVVTTPPKREALRAAPMRGRFHVGFDGWSGRCASRADPRAECLGRASSASRLLLLLLTLLRDCAAFSAEEAALYTQVVGSRYTKSSPPQTADNKTEVFIQLEVTFVGDIRVGELGGFQLHAWVSLLWRDSRVNVELLRQLGHRIMPEFLARSVWRPGVVFEGVGEVTRWDEPDVFVREDDFLLSRQRAVFQVLCLGQRDNFILGVTVCSLAVKLLHDADSLASLVWIGNETASPLRGQYESVVVHADVRPLVYTLVKVEPVQCDDASAVGSAPAIAADFHFSKVTWSFLLSTYVPSTMVVVVSWIAFWVDAGAAASRVTLGVACLLMLVAQVGHNRIASPHATQLQPGDVWFFVSAVAVFCSLLEFVLAHGSHRDKARAQGVGAAASAVAEPRYRVYRKPPTMNTLTIMCDAASQTERSYRAYRANELDVLARVIFPIAFMLVASIYFLWYAASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8K0</accession>
    <name>A0A9D4T8K0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8K0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058316"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10424" checksum="C08A9166AAB6B9BC" modified="2023-05-03" version="1">MADALWRDCANWLIRCQALPSDHRVTWANAQLIDLANTLRDGVLLCQLLNKLQPGCVDLKEMSLRPQMSQCNDDAPRKVVASILKLSSSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8X6</accession>
    <name>A0A9D4T8X6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8X6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029869"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="79" mass="8827" checksum="A9C72491C6AECDF2" modified="2023-05-03" version="1">MEEYTTTLASDRWMGICEYINGQTHTSKVWAILRSLLGQRKTYNGAAPVALREGISAQELSDKASEVFFPQTSRPTDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9T5</accession>
    <name>A0A9D4T9T5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9T5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033858"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12018" checksum="263126EA30BFB8BD" modified="2023-05-03" version="1">MSFGGGCGTHPIFDNEESERKPKECRCLSLVVKSLSTLSQPQIENSTDERCTYGELEELCSRVAAGLRSLGFGPGDMAGFHCVTSLDAIIAFYGVVFAGGRVVLAKPNLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA18</accession>
    <name>A0A9D4TA18_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_012562</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA18"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049326"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7983556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="312" mass="35224" checksum="92B7EE2B005729D1" modified="2023-05-03" version="1">MSKLSISSTSSSDDTSQGTLELAKEACEIRDVWASNLEEEFSTIRRLVQKYNYVAMDTEFPGVVAQPVGKFRSITDYQYQMLRCNVDLLKIIQLGVTFFDEDGHKPEDISTWQFNFKFCLSKDMFAQDSIDLLVSSGIQFPRHEKEGIEAYEFAQLLMTSGVVLSDDVKWLTFHSGYDFGYLLKVLTGENLPAAENDFFETLKFIFSSCRSLRGGLQEVAGQLQLERVGPQHQAGSDSLLTGATFFKIRKVFFQNKLDDKKFRGFLYGLGTSYGINGDQMFEVHASPHHVTRILSRSPTVVYSTPASRNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA86</accession>
    <name>A0A9D4TA86_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_013364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028623"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047090"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7983658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1316" mass="150182" checksum="777BCDDE6B56D695" modified="2023-05-03" version="1">MISSRSVGFQFVEKSDPLSSVWEPQERRLWKIVKLLRDSLSYSETRSLTAERKVKKLGECADFNNYMVYILTALEFQYEAAPKRGELVLRKYASARSGALPLRVTVHDPLVLITAALRYFIMTQSEIDLTQWPELLPRLGELLDLQNDRICHDTLAALHKICRNFVHVMNAHQPHDQLTVLVPKCLRFIQHRHPGVRYNAVAFIGLLFLKGIQAAMPQADAFVRRLLMLGFDKDCKVHEQVCHVLAILLAYHVDRLVPYMFRIVEYVMIRMKDRNEDVALKARAALAFMAKPICKEALTPHFSNLVHNLVQGTKCSYSATERLEEEEPGTPRRLGSTRETRDDVNFGLFVPKKDNVFSEENMRSRSAFALRAISRVFNEELLTLLLPRLRQMLQDKDWVIMESGIFVLGVIAEGCMEDMDLYLPDLILFLIPIRSDRAAVRCTACWTLSRYYPWVLTKPQHLYLSPLVRQLLKWVLDDNEMVQEVACNALMTLEEKAKASIVPSVLSSKVDAVISSRSVGFHFMEKSDPLSSVWEPQERRLWKIVKVLRDSLSDNETRRLTARREVKKLGECADFNNYMVYILTAMEFQYEAAPKRGKLVLRKYANARSGASPLRVTVHDPVVLVTAALGYFITTHSEIDLTEWPELLPRLGELLDLQDDRICEGTFGALHKICRNFANAINARQRHDQLTVLIPKCLHFFQHDNPRVRYNAVAFIGLLFLNRTRAAMPQADAFVTSLLMLGFDNDCEVQKNVCRVLAILLEYYVDCLVPHMCSIADYFMIRMQDRNEDVALEARAAFAFMAKPICKEALTPHFSNLVNILVQGTKYSDSARGRLEGEGPGTPGTLGSTWKARDDVNCGLFVSKNVADDNVFYERNMRSRSALALEAISTVFNEELLTLLLPRLRQMLQDKDWVIMESGIFVLGVIAEGCMKDMDPYLPDLISLFLIPIRSDKAAVRSTACWTLSRYYPWVLSKPQHLYLGPLVRQLLMWVLDDYEMVQEVACNALMTLEEQAKSNIVPYVDSILNTLHIAFLKYRHSRFYMLYNAIEILADSVGSGIIRREFMTYHIRRLTYEWDDMTDCQVNLFCLLRCLGSVAAALKSKFFPFHAAVADRCLRIAHQGRQGSFAQAIRLRHSTTPKKPFTIVALEALGGLAQGLGRYMDHFVLNSGICELMVQCASDPVPEVRQATFYLLANFTRACSNSISSSASPFLPLLVENLNPEIKPLYNNAAWAIRELALTSTTNVEPHVYKISVKLVEIVDGRNTSESLRDDLTQGMNDLMRHHKEWYGGATQLRRFCKKLPPTLSRRVADTYDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBL3</accession>
    <name>A0A9D4TBL3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBL3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11559" checksum="796722830D99A979" modified="2023-05-03" version="1">MDRPAEMAELLEAICGLSGNATPGKHNVMSVILRNSDAKTTAAIQTSREECRSASRVEHSEITLIPKLGKPQQLDSLRPIPLMSRLGKLFEHVVLNRTNKGPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC09</accession>
    <name>A0A9D4TC09_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC09"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053173"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="12020" checksum="113DE5C3E1443480" modified="2023-05-03" version="1">MDLLPTIAELARITLPPGLVLDGQSLVDSMLGRNETPSESVDSSEYREKIGPILEIYQKHRCSLVPGKPQLDWCDDAAMQWAPPGCEKIDRCLPVPPSRPYRCPWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCI2</accession>
    <name>A0A9D4TCI2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_024379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001134">
        <property type="protein sequence ID" value="KAH7985004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCI2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030944"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000268">
        <property type="entry name" value="E3 ubiquitin-protein ligase NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7985004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="167" mass="19164" checksum="87C42CADDCC94D10" modified="2023-05-03" version="1">MGYDLCRFQGDVDEELICPVCSGVLEEPLQAPQCEHAFCQGCICQWLSRQQTCPVDRQSITAAQLKPVPRILRNLLSRLQMSCDNAQFGCSAIVKLDCLTSHRETCEHNPRRPVPCEQGCGLVIPKDELKDHNCVKELRSLVQSQQQRLNEFQLEIREQWREINLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE89</accession>
    <name>A0A9D4TE89_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000082">
        <property type="protein sequence ID" value="KAH7987773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE89"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7987773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="11733" checksum="D9D585A5C53364C6" modified="2023-05-03" version="1">MSQIGVADSVDMTPEEIIDWREKFVHSGAKKPLPTSPSTLTSRPQVSHILPRPPPLPAAEYKVILRVRGGVNCASIHPVSLRDIVIKSTGLSAAAASLDRLGPMRLTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBT3</accession>
    <name>A0A9D4PBT3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBT3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12371" checksum="6B0C42DEC2005BF0" modified="2023-05-03" version="1">MDQASFTVVSYKKKRGTGVPVVFRPTIDGGSLWKVNPNIVASAVVTSAQDRVLNHCLNKDGSLMVAVSTLPTANRLLTVTELARVAVEARVPYSYTANYGKIQDVPLSYSNEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCZ8</accession>
    <name>A0A9D4PCZ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_014641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042010"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11800">
        <property type="entry name" value="SH3_DNMBP_C2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="53"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1179"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1179"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1391" mass="154860" checksum="7EE1B882D6E84DCD" modified="2023-05-03" version="1">MSDVATSINEFKRRKDLVSKYKKDPSESTLSRRLAKLNLHSVLKKSSRFGVRLSSTFGLTSVEKDEAFERAEREFRVLEKALKLFLKNLAVFCDQMKQTVHVSLQLSEDLVQYYHDRKSLPEVERYRAVQHTICSQHWHEFATAVERDVEGVLKQLLQMFVGPNKLITKRQHKLLDYVASKSRLEKNRDFTKQKALSDEQQLAKNTYNALNAQLLDELPKLCGIAREVLQSCVQEFLRARKTFIGRTTREMLTLMELPMMLSAKGNSNVLENFRIKHSLVLKSLAEEPSASETNLFTGLLAKAEGGGTLSRSAGAKMAARLGLGSSTSATIPGKLEPQTEMQRVFLRSSYPMEFIYTVAEDYASSDILDINLRAGDVVGVVKQQDPMGNPERWFVDNGATKGFVAAKFLRPLHRPQGRPDSQLRASPQPPAAGGYDPPPPYSATDPLRPRTPTQVLRVSPSPQPAEQSSNVLPTKRIAASQRLTACSIQLSSRSAIQRDHAQLPDGRAQLSLLRIAEPALRGHAPRASCLEIHVHTAPSDRVFKCFFVLQSRLLITFMEIQRPTSPAGATNTEAEMNDMEPTFDSNSGKTLCKNGPWMTLLARQQKKKEFAASEKTQKESACHHSQGQNTNDGKPQGAPQKYLGHNNASKRFSRWPTVPSLPENHYKIVYRPQAGMKVSNLKDGVIVRGIAQACGVTLQELYAKVIIQTQWHQDLILASTEEEECALKLAQVTHIQIGQTAYEVTPYLKPIPGTVRGVVHGIEEGTTDEQLEDLLAMNNCKILYARMLGRSTSAVITFEGPHVPFYVKVGCTLSRCRPYRKSVQYCRSCGEIGHRQDVCPNPNDDICDNCGEQNADPNNHKCELKCKLCGMPHETASRECRRKLKPAPPPLRVRERSRSRQRSFGYQNNVVTMNDNDHTPDNVQRKLSWANVVTGHSHSSMESTSTPTTKHYTYEETITILRRENEELRQALELQKRKTQEKEASTEKQLEYLMREIEQLRREQTQNSQTPPSRPPSPPPSSPPQPKPATLANQTKVTQNDLRVLEDRINANMTVVMDDIMSKVSQVVETTVTQLLQTGFQTLKSEMENQIRALETKMTQSGESFSQRIHTLEERENARKKPKKPYTYAEISRPLTPSTSQATVPATSHLPSQAMNQSGYYQGYSSSLAPSSAADVQNAAVSGGTSQSSVVPSTIDPRRSSLGLSTGSHGKPDDANTMAASGNAEKGGGVTTYNYSFAAGQTERHTYEEIPEEKGPSIGSPIREPETTGSRYANLEFDPLSDGGTRPSCAVLSLQKGTKTAEAKTEVGSRYGNLDAMGASVAGNPPITNEYYYALYPFSAAGPHQLSVAQGQVLLVIHQCDLHGNPEWWFVQDRHGNQGYVPGNYLHRYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR0</accession>
    <name>A0A9D4PDR0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="178" mass="20049" checksum="1724592904E1B42D" modified="2023-05-03" version="1">MRQQLADTINRVSGALLKSLRKLSFENREPGVYRDVTDVDLYRSTRRQLDMSWTDLTLTFNTDGAPVFESSKNSIWPIQVLINELPVALRWQNIALSGLWFSKSHPPMHMFMAKFAEEVRSIGTLAWASAGTVIKSAVHVVLCCVDSPARAALLNMKQFNGYYGCSWCREKGTCVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE02</accession>
    <name>A0A9D4PE02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE02"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049144"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7936431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="16813" checksum="C3049584A6591A11" modified="2023-05-03" version="1">MECWVAVCSYQARRPDELSVTAGERFRVWPQQQVQPGWLLGCSLRTGAQGYLPAAYARPTGALDDSGYSEQAFEVAVVASWTGGVAAVAQGGKRVAIPPERGQPCWLAWARFHLWWQMMWRPLSASCQSPLGCTVAVSLHDDVARHPAWTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF25</accession>
    <name>A0A9D4PF25_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF25"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9389" checksum="BBA78F4701597CC1" modified="2023-05-03" version="1">MKMSAHATFSTGPIMRHGMGSDAAGLDEPLTTEGSQSYLDVDVQLVKGVKRGKQGSRDARYLTEATPVLVRVIEEQVVAQRFAHGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGA2</accession>
    <name>A0A9D4PGA2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_021858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGA2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035348"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001909">
        <property type="entry name" value="WD repeat, SAM and U-box domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7940109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="74215" checksum="56D477B0BBECF183" modified="2023-05-03" version="1">MQVSSANDVKIYNLSAGRSLPEWLSDRKKRMLAKKNAEIRHRIELIQDLEMPVVSTNVAMSRDGQFVMVTGTYKPRVRCYEVSQLSMKFERCFDSDVVTFDILSDDYAKMVFLHCDRYVEFHAAYGRYHRVRIPKFGRDMAYLPASCELYFGCDGAEVYRLSLDQGRFMNPITTEATAVNVCCVNSYHNLVCLGTQEGKVEAFDPRSRSRVGILECALNSVTEDTEVDGMPSVTALTFKDSLTLGVGTATGQVLLFDIRSDKPLLVKDHLYGLPVKKVAFHSDANVVMSMDSKVLKLWNPTSGKAFTSVTPGVDLNDLCLVGNSGLFFMANEGKKVLSYYIPSLGPAPRWCSFLDNLTEELEETHQDTVYDDYKFVTHKELENLGLGHLVGTNLLRAYMHGYFLDIRLYHKAKALVQPFAYDEYRKRKIRDTVEAARKNRVESKLKLPTVNRELAKKLQEAVAAPRKAPKTTLLEDTRFKAIFENPDFEVDPGSEEYRLLNPLVKSLDKRQKNKVAESGIMELLDPVEQNGSSSEEESSDDDRTWTREVKKEHRKIRQEARSTPGVPKMYELKSGVELHGGVLSGKTESVATVKKAAQKLTLAQRLERDNVGTAVGAGGNRMMTFESRRTKVERDREEKVKAHMAERREGLQNICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGF9</accession>
    <name>A0A9D4PGF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039879"/>
    <dbReference type="OMA" id="CAPIARH"/>
    <dbReference type="OrthoDB" id="17536at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16094">
        <property type="entry name" value="PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7940052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30667" checksum="1B21FF6E4F124694" modified="2023-05-03" version="1">MATFFGEVLPIHSRAVDDNEDENAESPSVYFDLDQRYQDVPSLPAYDLVCVATGIAPSIFVQCYLVPDSHQVLGTIRLNPTKQQDSSNDPSGNFWGLDYSRRTDVLGKLIHYPGHGAGVLYCLCDKEVPFESCAPIARHFVELSKSPRVTSVSFAALPASDYKSKGRPEFPLLRQLRTFGSARNATEDAIPDLETPNTVSGMCAAMLTECEVGDMPGTLFVLYTDTPEVDSTVVKAFEPTLRLNCLQALNQPLDNCRNELLRRLRDAKIDRGYLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGN8</accession>
    <name>A0A9D4PGN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_018536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050161"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14456">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7939867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="665" mass="73286" checksum="DE38731D5DBE9628" modified="2023-05-03" version="1">MALGAGVKRHFPMRKVDDVVEFFRAQLESDNEPDLALLSIVIGYIENLLTFHRNVEPASGGDPRQPCFPSVEIGPIEALHAKFACQIKGSLDLSAIETDSPAGMRDLIKRVSDAIWSSLTRSYYKDRPHLQSLYSYLTGNKLDCFGVAFAVVAACQTLGFPDVHLALSEDHAWVIFEEREETAEVTWHGKGNEDRRGQPIPQDKSWLYLNGHAIPCTRATEVAALVSAINPTITATTDSTELVNLQQQLLWLLYDKGHLRNYPMALGNLGELEGLFPTPGRPPPQDLFAEAVHASRTYYQNHHVYPYTYLGGFLFRSGRLKEALRAWADAADVIRKFNYGREDEEIYKEFMEIANELVPQLVKLSSTGDGSLLQDPTCFAHLLRFYDGLCAWEEGSATPVLHIGWARPLVGTIAKFPASVRSAVSVHASTGDEEEEAEQKNHKDAPPSVSKEDSKKGSETSSQDSLMADGKMPKEEDFLKSMENQLGQSNGPPHPDIVALAAAVRGEHPQPRLPLGLRGALLNQKRQQRESDFMVGDLFDPKVNGHACPDDLIRAVQQEANNNNSSFSFDDDDLDLDDTKAALSAKPEKSGSRSSGDNGVATVTLSSQKMAGLKDLLLAEKLNTSAIQLQLTAQSQVQVVKRGQSNPAGGPHEPTTRHSKRTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH92</accession>
    <name>A0A9D4PH92_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH92"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035489"/>
    <dbReference type="OrthoDB" id="6492345at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49608" checksum="6035C9C5D62F61B3" modified="2023-05-03" version="1">MRDPMYFENYGTALDFEVANKGEKVLVPNYLVNVLSAIVVLATCVTVVGVGVASFRAAKGEHVGTLEASTAVLLPDANDALDHRMAEEWRTYMPSPRPILCFLNREGFLRPPPDTFILREFPGFYCNEIVYNGMAFDSATLHLLADATDDAIIYQLNRVRKALYPHWRIVLNVFVDGYTTKKMQDGQTELMDLLFSWLERRRGVDGINFEFADDAFLGDIDASSEVPSFFASVKADQRWGNRTLSAMMPYAATVLLLDELSLTIDRILVKTHGLMDESSATTQLTAPLDYAGLAHRRSNHRTVMGILEELDENLGRKTCFTVALSGTVFTLKSPSECDVGDPVIPRRPGKASFSNVCEDAPNRVKKIEDDVAYTSENYTWVSHEDQFTVFEKTAKVLRHWNVLCVAVVDVDLDDVRGQCGRSYPLLRRIYETSYMLKYSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHM2</accession>
    <name>A0A9D4PHM2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHM2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11789" checksum="3F4C809FE0EEED76" modified="2023-05-03" version="1">MRGEFPIKLLLEPSSTVVLWPLVSPKEVKASSIQKALHHPSIVLPKPYNISGNSCQSLILRILKLIEFPVPRGLRTCEKEMARLLEDTLVVSFVSTLAASAWVAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI44</accession>
    <name>A0A9D4PI44_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI44"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051329"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13344" checksum="06FDE08EB7D4F54E" modified="2023-05-03" version="1">MLLSDYAKSLSDPERRRYHIKVAKCGSDDPLALSDDQFTNDVGCYPSVDRADINDYLVHGTSFVTREQLKSYKSLEAHNYVTSGLVEPPRVKTLRDGNIVVVSKPRLRLSAQSGLASSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIL2</accession>
    <name>A0A9D4PIL2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIL2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048320"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF1">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77423" checksum="FD113CD859039D1C" modified="2023-05-03" version="1">MTTFTDGGDTRDIVERGGMDRYRPPCTAYRDQVCQINNFLPNCNELLFDIGLELREQRGGSLSLMSIEITDANLTSTPGPDSYRATRFLRWLLQTHVCISSLELIDNWLKSHTVIILPELPEYSLLKKLTLTFYEDDAVHTHTATVLPRLRSLEVLNCFVMCRSSDALVGAVSALLRTTTCLRSLVYHATDDDSQPPKSFIDALAANSTLKSLELVTGWKTDEPPGHLGEYIKSNRILTSLSVCGLDVDRAELLLEDAFVNNSSLSTFEALNVCGGETTARFLTRLLAECHALKKLAISDVSADEFVEISEATLARCADALAKNESLEVLKLPYSLWHPNNWITFFSFLPRNRHLKKLKIDHEDTDDYATFPPVLEALAQTNSSTRVTFGDYLHGSGVDFMNFRAFSGISLSGEESVQVDALQRLPALDHFTSLSLDLYEAGEGVFSALAKYIRETAVLRKLTLTVTKPFEEANTAASFCWKFLFESMSANTSVSDLDIFSNGNFQYNDHLARIIGLSRYISRVSFFLNAGDGTATDFVSFLSEAIGGNYNLLNFDLYNSKLGVEAKRCLVMIRETTRRNSGLLERAAAFNTTTRLDWYTATALEKVSRNPALLRELAKKEGIAARQVASTIRSHLSSVEGLNDFMRLTGVVKECVTCSPRVVGSGMQLQDLSNDCWRLVRRYLSFDDVKCFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIY6</accession>
    <name>A0A9D4PIY6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran gtpase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIY6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039767"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="73793" checksum="716755F5E374607B" modified="2023-05-03" version="1">MEGELLAITAELLSVSCTQSDTGRVCQLVRHLTACNKVLCHASLQLREDARDDPGYLSIATVDSIFCMCSRSARNARQALVLARKLLTSHRCVVSVEAMYGVLNASVLAESLASSSHLRRLTVSDVEEDRRELLEGVSGDERVFGQDHEAKMEIPVRLLEKDSAQLVSLDVTSLRMNPSMAKSFVDALIRNNTVAELAVGADVFTSGPAEGTSMRFAQYLVKKNATLRKLELNAPSLVLGTGGLQALAQVISSVTTLKDLTLLFQAASPDCSLFFTVLAGSQSISVLRFLLAASDDDVIDPQPCEDVQVVPWVSAFKENSTLEELALNASWSTSRECCLLLEALGQKPGFRSLGLRSFPNDGGLQEACLTIAKHGLERKVRMESYCIVPEDTETFPSCQQVTGVMVSSFYIDEAAAMTNVFNVIAICVHVTSLRVYLQFYDEQAFDSLAAYVRGASCLKEIDLAIDIDYSDGEEDDMEVDDERQFRSISNLSKALSSNPGISAIRLNSTIGIGDDDCQALADAALNNRQLHELSVNCMEDSSPCDARDMLCDVQDIVRRNCSLVDRATKFVMGEHVPYCARAFEVVSEEPALVFNVRRRLTADGSADAAAKVSAAQRFLRIADVHTYMRLTGVVEERMECDDLQDGGQQLNQLNHDCWLHVLQYIKLADVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJY7</accession>
    <name>A0A9D4PJY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJY7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30174" checksum="2FDAD58026FF9212" modified="2023-05-03" version="1">MTSLQELEARWLCRIADIGLFGRVLGSNASLRVLDVRCRPCCDQGAHQPHLLASEASVMASCVSDLKRHCYLRRLAVDPSLCTLEGCRLFIGAIANAPVDAVTVRNVADDGCLQALYATIRQHDLSRKVIVEDHHVGPADVKFVADFVLDSWAHCELSMEALESSSCWVLLWCLCPGVTRNHSLLVATLPDCDAKLEFETATLHDVTRRNRHLVVLASRFVILYPGGDPYGRDVLPLVAKHPKLAKTTAREAGVTETVAETMIADALQLVAPCPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK47</accession>
    <name>A0A9D4PK47_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_005837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase F chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031898"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019344">
        <property type="entry name" value="F1F0-ATPsyn_F_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13080">
        <property type="entry name" value="ATP SYNTHASE F CHAIN, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13080:SF20">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10206">
        <property type="entry name" value="WRW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7943146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12531" checksum="E1FB3F134E13BA33" modified="2023-05-03" version="1">MAFGDYPPEYNPRVHGPYDPSRYYGKPDTPFSELRLSEIPAWLARRNKNPRAFAGLCSRAFWRWQMKYVQPKYAGLTPLIQFAVGTSLIFYYLNYGKLNSASPVSSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKA2</accession>
    <name>A0A9D4PKA2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKA2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="472" mass="52725" checksum="4A2F1C6EA0DE2A36" modified="2023-05-03" version="1">MRPPFCPAEGYRHPVLGELRFRYEGTFGKPSSGTATLVLACHTSHNAAVGVAPTATFAVPAQHLPRYSSHSVRIQASVDLSIPRKGGQLLGGHGAEHFPFRCAAKNPTETRNDQVCLINGYLPICNELLYDIGMELRQQRGGSVSLVCFRPQEPDVMPPPDADLNRSKTFLRWLLRIHVCIDGLKLQYKWVTAHSQVFLEELPENCRLKKLRVQFPFGDTVQTNFATLLPRLRCLEELYCYMFPSTDVLVAAVSELLRTTTSLTSLANWNTDELPGTLGEYVRGNGLLTKLVFFGEETDREELLLDAALVSNGLLELDERLFYAAANYIRATTVLRKLGLLVTNAAEDAPFWWWKLLFESISANTSIADLFYSASDNCSYTGHLASTVGLSRCITRVYYSKKLPEWDATCFIRPLSGAICDNYNLLKVVLSSNATVGAEARHWWFTIRDTTRRNSGLVELAGAFNQATAIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL33</accession>
    <name>A0A9D4PL33_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030417"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="521" mass="50266" checksum="0B2BE9860882E513" modified="2023-05-03" version="1">MKTAAETAFARERHKDDALFEGGQAAAFSTACNHYQIHADLQQFMPSTLSAGTQAGSPGATQYAGGASQYAGGASQYAGGAPQYTGGAPQYAGGAPQYTGGVSQYAGGAPQYAGGAAQYAGAGGLAQYGGAPAPAVQYAAAPQPTGYGGGNSLASFGGSGYGAAVPQLGGAFNSDQNAALAAVQQVLNAERQQQHAAPQAQAYTAPQAQAYAAPQAQAYAAPQAQTYPAPQAQAYATPQAQAYGAPQGFSLPQHLFAAAPQQSYAAPQRSYEAQQQQQPTYSAGVHGSGQALAFAYGGGGAPGAAAGYAGGYQPHSGYAGGPTAADTGSDPKYGAHIFGPAQVYVPPPGATGQGYGAGAASTVQGGYNGGSAASSYGGAAGAPQGVALQTGPGGVVTGAALQGYGGTSTGAYGSGAGGALQGYGPGTGAAFQGYGAGAQGVSYSPSAAYGGAQLAGQGAPGVHYTSGSTLRLQAAPYAAALTAGQGARSGGYTAGPGGYGAASSAQLTAYRPTAQPGYKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL71</accession>
    <name>A0A9D4PL71_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL71"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056439"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="561" mass="63058" checksum="408CBC7293AB1B1A" modified="2023-05-03" version="1">MNVRLRANEPASKLAERLSHAGGPLAVRDLDLTNCFDVNVHQLVTLITQCKLLQHLRCAACNIPPSDVLMLVTQRLPHLVEVEFSCLVDRRIMGAEISRLAGMACNLDCSALKLQRVYVEIGQQHNFRLLSIFLRCCPNASSLHVHLVCGEFHEAVRECHTLLEITDNWTRSGSHPSCLRPFSAIRPVLSISPSMPQSAPTSPTRGPKTCGAAHDYRTSRRPASNLRLYHFRRPWSRSKTNSHLNGFARPASHTTGGTCDNYASYYFCPHLSNTFPAADGTYRDCLREFSTRLRQLVELNVSSFHFGPGIDVTAFFEGGWMPFLQSLSAAPCGFRSVLTLKCLATYCPDFKELDVRFESRGSFCRCAGCESEHLYVNGFHSFASPVFRNGLARLTLSRVHDAACLSFLECCRPVATLRLSYCPLELDYERMSRALAHSSDPICLILQHHLLRLGDTDLLENLHRFTDLQYLYLLLHTRLDERELPSSMTCILRSLPQLKCFHVHYVCDANPEVLRTATWMRGPGGAMSDELVRGGRCFQSCSTATFIGLAKPLNRDFQPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLK4</accession>
    <name>A0A9D4PLK4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_009790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLK4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055681"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="215"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="653"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7947302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="828" mass="91444" checksum="04A2415D736CDEA2" modified="2023-05-03" version="1">MRVQVPVPETSITQGSPAGKQPSPRHSYSKADARRRRSKSARSATASGSELASPIIDPARVPQEPESGACISPDDQCAKGGASPQASPPSFSAEENDQQRQQPSVPFPQAKSSDVPADARASSPAANSAQLLSRPDEVRSRNPEAVISKTTLQVPRKYDVVTIILITVAVGTLFFVTVFLVASKHAARRLRLCHTEDCGSHAALLSRAFDTQLDPCDDFEAFVCSAWHASETRREQAMSVMDDLRFTWYDHFEDTLTRGTKKFQAGRKPLAVYHMCRNNFPTNASQVSLILDFLAHHGLSWPEPPEKPRPPLALLVTLSYKWESPYWITVRLLEPSASGNRRVQVTPGLYLPILRNNYYAITAAYYRYWQMFLELIYPDPDKRPAINTTVVNDIRALEEDVLDSLHTAAESPRKRPATFPFSEIGTHVPNTSAVEWAEAFQAGMSLQPNLTVDDEIVATDVAFLGAVSRLLSKYGPLKLNQHLTWLIMQNCPPATDYAFLLGYYGSEEKAAAHASSHCAHKVETLYKVLLLALGLFTRLTDLDRKVIEAGFNSLISAASGSIRNSRWMDDRSKAHAVRKLDSVRNDMWPPVAILDEGALEKIYAAFPEKEPSFADYWIKTLEVIGGMDRTPEYCKALSLPSNNFPDYAGYDYVTNSVRTAIGAVAAPAYYSNGTKGMLYGGLLFLMATQMVKAIDDEGIRWLPDGTGADATILSGRTLQAFRDRSECPHGGNSRTVFPEVPALEVAHAALTASHHADQTEPLALSNQLPEEKVFFMTLCYMSCSKPARRPGFLADCNKAVRNSDAFSRAFGCRKGSRMNPEKKCSFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLL3</accession>
    <name>A0A9D4PLL3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coilin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLL3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046711"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024822">
        <property type="entry name" value="Coilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031722">
        <property type="entry name" value="Coilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197:SF0">
        <property type="entry name" value="COILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197">
        <property type="entry name" value="COILIN P80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15862">
        <property type="entry name" value="Coilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coilin N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="432" mass="47022" checksum="20F32D55074158FC" modified="2023-05-03" version="1">MADAGAEIRVKLDLRFAVPHREAHNLVWTVVDTAETATVKQFAKLIRAKYGVPKKSELYLDDAWLPPDEPLRILRDKDTVRVVTPAQQPSKPDSKPDDDPAPVPNQFVKTTKKKRKRESSESSPPPAEEANNVSYAAGHDHSASTVSTPKQGATPYLPAVQVPSTPISFRSESVCSTPQNTSSTSTPAWPVPAPDLSMSLSTSPPKKKRRPRRKKKKPGEEGTQVAESPSLPVAPPVCLTSQVASPSLPLPVAVRVPAKLAQADLPTGRHVHFDGDSSDDEEEEEVAVEQKAQPAVFEQLPHVTQVVASASMKHESQLPLTNGQALSWDRPATSCYSAVPPPAETATPKAKIPEILELDADYCPNVSEYKEGKVLQHNPVSDFVRIELKRAEAKKTYGGKFELEVPEEGLPPMEKVVSVLWTELIDPVVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMM6</accession>
    <name>A0A9D4PMM6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMM6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039455922" description="Mutator-like transposase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mutator-like transposase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="296" mass="32476" checksum="BB0DEF2BE26353B9" modified="2023-05-03" version="1">MAVSFLTVLFVLQVCVGSDPRQLRHVVEIDGDCAASTPGSDAEGNEGALGVVPRSAPDSGRGVSSTFRHDTAMLQPEDLRRIDNEAQGKLQVLASTSTTRRKSDLLDRADDVAAQADNELATSFFIATYDSLNALLARAYLALQEARVYGYVPVEKEDCIDHIHKRMGMALRNLISKQKSSGTESLGGKGKLTGELITKLSSYYGWALKSHKGDVKAMHKAVMATYYHITSNDRAQSHGVPKTQHRPKVSLLRSTATICHLKYVRRFFSSTDVCLTKHFFSDAQEGRPRITSVSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMY3</accession>
    <name>A0A9D4PMY3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMY3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="25424" checksum="A34CBE1E3AA920F5" modified="2023-05-03" version="1">MRVYERARFLANPPAWVCAKVIGSTLLYSILLSTTTRIAKDSTLLSPFNSAFEEASPPPNQLRNSRAPRKLAVQLLSCVASGVGCCIVLLWGLSHKIMRLQFSQKEAQPESTEQPSCCRAFLEGLTIDRNLDPCEDFQHYVSARKSRESKFRWNDWNARKALLYCRYYPEAAILGDWLAFYARTAKPCWSADPRSSRQKWRQRSGTQPRFRMWWTLTSCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN06</accession>
    <name>A0A9D4PN06_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046755"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16696" checksum="47026C28E2BB075B" modified="2023-05-03" version="1">MRDAASRKRDLTLDKIIITCKAAEISKKHVNELQEPNFELQALQKPKQWNSKKAAAVGNRQKKPQLKLQEKCSRCETTHRPRECPAYGSNCYNCGNFGHFASLCRQGQRGSSTSRRHLGLLEDPQQEDRQQEFFLGSLDLHNINSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNC0</accession>
    <name>A0A9D4PNC0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041447"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038581843" description="Serine carboxypeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7946976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53932" checksum="9CABD1BCFC27A685" modified="2023-05-03" version="1">MKSLVLLFFVIWTVLFTKLFPRRKHTLTDEEKRRLDKPLFLTPFLETNDTENARSLSRVTLFEEEYGVEAHSGYITIDKTLGSHLFFLLTKTKHPSPDEAPLILWTFGGPGVSSLLGPLLFNGPFTLDEQGRLTASSPASGQLQSFAHVLYLDHPVGSGYSFAEQEDDDRTFPKNIDDAVDAIDDFLRQVELLFPEFRGRQFYFAGESYSARDAFGYANRYHGKGVKASLKLAGIMSGAGFIAPFLRAANPAKFLLQLGLIDVHGRRELDEKFRQIKESVDDEEILVALLLLREVFTESADGGPSLFESLTGYSHRASALRSTEPSEFAAYRKYVTSDDFKRAVHVGINATMDRQSKIVSTTLYSYDAFKDIRELVATVLDKERVLVYGGNMDVVYPADDVYGFLRSLQWKGEEDLRIAKRRPYKNASHAGGEVVGYKMIARNFTYALLVNSGHYVSLDSRRAVVGLYRDFVYSNVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP73</accession>
    <name>A0A9D4PP73_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP73"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053449"/>
    <dbReference type="OrthoDB" id="5973838at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="37579" checksum="F1862AB6D79DD2F1" modified="2023-05-03" version="1">MCRKSNKPCLQYYKGVPLPGFLPREYIESASKYKPTKDDLYIVTYAKCGTTWTQHVVYLIQTGGVPPANAEEFYRASPYIEAFGAECVKWMKKPGALKTHLPVQLLEYSPEAKYLVVVRNPRDVIVSLQYHWLSFFGYHYNGSFDDAFELFMNDESDCGNFFTFYKDWYERSRDPNVLFVVYEDLKRNPEELILRIARFMGEEYEANLLKNDRKGLRDVVKYSSVEEMKKYTNDIIREFFRGSFDFQGPEYEGFRQFHRGVHSAGVEAVNKINYVRKGIVGDWKNHFTPEQLKRLNEKFRKETEGSDIANLWPEMNFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQE3</accession>
    <name>A0A9D4PQE3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_005331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQE3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028751"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030312"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="226"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7951152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="643" mass="69986" checksum="0043CFB76B5E2FF2" modified="2023-05-03" version="1">MPKTSPKKAPAAKSNKPEPKKAHTGPSTNAKPGTPSKPPVLMVKDFPPLTPVQAQVSCWGGAVSGPSPSPSPTETALQQQIEELRRQNRFFARKIQELEAKQVGSSEPEQGAEVEDGDDGSSVTSDLTSVSRRDADTVVGSVSATGATGRLESLERKTEQLEERMAALPDQIMSAVRASFQDMFTAALTQALPEIVAQVSDSVLKAVQPWVSTQIKNTTQCDSPQLKRKTASRQAVDEDFSGLAPGKKTLLNRLYGQANPGTLTAFMGPSGAGKTTLLNILSGHYDKGYKGEVLVNGYVREAKLFNLQSSYVMQDDCLLGYLTVRETLTMSVELRTPTCGRRKISELVEDALDLWGLQGCANTLARSLSGGERKRLMIAQELMSDVPVVFLDEPTSGLDSCSALRCVRVLRTLADNGRTVLCSLHNPSASVFSQFDRLYMLSDGMCIYSGLTERLVPFLNSMNLHCLTFSSPSDFLTEVASGGHGELTVKLSSLFIPEGCPVSSEKERDDQGMVTIYGGRLMTHKTVVFVASPLCSPLIVFSGFYVKPQHLLPVVAWLPSVSHMFYAHRAIMFALYGGGRGELDCDDSTDAGICVPVDGYYVLEVIDASDVNLFVDFGAILALDVFWKLIAFCLLKWRLWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR04</accession>
    <name>A0A9D4PR04_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR04"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054354"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="329" mass="37566" checksum="7B2E439D840D0A94" modified="2023-05-03" version="1">MPGCCCAPNCKSNYAGEPSVRVHVFPNDPVRRAAWTRAVPRKDFAPTKNTVLCEKHFLASDYVKTSKYTDQKTGKIIEVPLKVFRLKPDAVPSVFPNCPQYLSRQNECTREAPEEKRKRLEDESLRTAIEKSLEEKRQQDKQNKVASFSEFLHALPSFNTSPFWSVIKMDSKVLFLDLTVDRGASVRSSVIVQDSMCVEVYFGETLIVELDGVSVPAELQDLRQLCDILHHVERLRTPDASNNVQWARQLLATVMVLLEELICNDQQHQLHGWHLEIVKFIKSQVELILNNAARYSPDLLVFASLLYTISPHAYRFLRGSLKDTVLMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSK8</accession>
    <name>A0A9D4PSK8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="16">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HPB52_019676</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
            <tissue evidence="20">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Degradation of blood coagulation factors Va and VIIIa.</text>
            <dbReference type="EC" id="3.4.21.69"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="16"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSK8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044227"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007599">
        <property type="term" value="P:hemostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000011">
        <property type="entry name" value="Coagulation factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF116">
        <property type="entry name" value="FI16631P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015155" description="CLIP domain-containing serine protease" evidence="16">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="12"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="19">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7952168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="335" mass="35879" checksum="73E08842512EFCE3" modified="2023-05-03" version="1">MLLWLVVVAALLVTGQATNSSTAAPRQTDCRTPDGQEGFCIMASQCRPLALLSSSQQRRYVCGYRGPLAKLCCAPEQDSGERADNSTGVVSRGAGSDGAAIAPAPSPEPLPEGYPNALPSVTPASSEDEWQMSVRGRGWLPARVLTVRVGDHDLNSSDDNTTPMDVEVADVIRHPRYDRRTYANDIALLVLRKPVTWGRYVMPVCLPFGPLASNTLDGHNAFIVGWGATQFNGAGSSVLRQAQIPVWAEAECKKSYAQHLPISKSQLCAGDAGAEMDSCQGDSGGPLLLPHEGRYYVVGIVSSGKDCATPNFPGIYTRVSSYLDWLRDQLGVGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT22</accession>
    <name>A0A9D4PT22_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_023814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="228"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7952488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="502" mass="54804" checksum="C5318399BEBD77F6" modified="2023-05-03" version="1">MLVRARESRSSAARAEDVVIEEAPVSHGVRAKPECRSATQGHIPAAATESVRAATEVRRPEVVAAAAASDGVGPGSPATGLLLVPGSQRWEGLRYLVYWGLVSGLLVLVLGLVGFISLPAVRWAPWEWGFGGAAAGSASDPDAGEEPAARGIGRGGPLAQPARRAPPRRLKLQDAPRVRPILGVRHVSDKGLGVGGGAEGGAASACSTPACAEQASRIQAELEYSVDPCVDFYHFVCSRWIQRHPRGGSVDLLQIESYSSRLADLLERPSEQVPEMQRFFANCLRPQENLFSEIRATFFYLLGFQEWPYLSSAASFVAPDEVSSKIGAVFRELGVESLFRFAVAPDPEKPRLRYWALDEPRLLSTGGEDGAWMDGAFKASHTAILLQRRKQSHDRSHFCSDTAKWASSPGNPKALLDFYGKFSDTNVSRLEHELSSLMERPELDPLALSRCKTMALVDLPAIDYLRWAPMLRSAFGTDDIFPQSWLLQVTRLRSCYLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTH0</accession>
    <name>A0A9D4PTH0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTH0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="151" mass="16238" checksum="54F386EBA01A4B05" modified="2023-05-03" version="1">MLPLPKDDAKIIIRPRGGLDVSKAGATTVGRAIMAAAGVTEAHAGADVICPNLQQNIIVVSTPDRDNAARYTRMKSIVVMEKEHEVNAYEAAPHCTCKGVIRGITPSDSPEELERNIINARNPLALAAKRIKNTGSVIVAFDGWKVPNFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVH7</accession>
    <name>A0A9D4PVH7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVH7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055326"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="23832" checksum="EF93369781161112" modified="2023-05-03" version="1">MAMYWGTSRWSAVEIMEAYTVARQCHLVPPVAEQTEYHMFHRDKVELQLPELCQKIGIGTMSWSPQAFGVLTGKFDEGQYVSAVTDKVDRPEKAICEESGGRFTRQHSKLQELSYIADRLGCSCNQLTIAWCLKSEHVHTVLVGASSVDQLYDHLGALQEPWLGPRAPIPDSPGSQQLQPQQHIALELDDPGPAEEGGRVQRFFASVAHACVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX20</accession>
    <name>A0A9D4PX20_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_017930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX20"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035437"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09336">
        <property type="entry name" value="LIM1_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09337">
        <property type="entry name" value="LIM2_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000012">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047075">
        <property type="entry name" value="Paxillin_TGFB1I1_LIM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7957340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="306" mass="34430" checksum="1F8C540CFAB5037F" modified="2023-05-03" version="1">MGLNGPQAQSPIQSQQRQQLHGSPTPVSDPAYAKPHRLNRPNQPPGNKLDSMLGTLQSDLTKQGVTTTAKGHCSACSKPIVGQVVTALGRTWHPEHFVCAHCNQELGTKNFFERDNEPYCETDYHNIFSPRCAYCNGPILDKCVTALDKTWHPEHFFCAHCGTQFGEGGFHEKDGKPYCRDDYFELFAPKCGGCNRPITENYISALNGQWHPECFVCRDCRQPFNGGSFYDHEGQPFCETHYHAKRGSLCAGCHKPITGRCITAMFRKYHPEHFVCAFCLGQLNKGTFKEQNDKPYCHACFEKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY30</accession>
    <name>A0A9D4PY30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_017238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050250"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="72"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7957302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="35612" checksum="D008A5B40FAF74C5" modified="2023-05-03" version="1">MNDKAVSMRGNDVPVTRLGFAPYRVMLSMIREIEDKLKEGKSLGFPYLIRGDISDGQRMGLTPITFLRQVCYYLDEDHGWAHNTDEMQKALDASKSVCVPRCLLLVNPANPPSTVLSMKQLQDIIMFAHKNHLIILADEVFEYNIYDINHPFHSVRKVMNTMSAPYSRTALISFNSLAKGFTVEAGLRSGYFEAINLDSVDQAYLEEAMEADRPSMLSQVRLKAALDCIVRPPGLGDPSYELYTKEKTSTLDSLARRAKMAEKRLNAIPGFHCGPVQGSMAAYARITIPAKAIEEAKTCLPILTYQDWRESLASSDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY64</accession>
    <name>A0A9D4PY64_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY64"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="273" mass="31469" checksum="B47252815E34A049" modified="2023-05-03" version="1">MGRTRAKRSQSAEASNKRDSWVACTSCDVWIDIEVTPFESVAEASATAHYDCKHCVRLNVLLEESAQLLRQHKEECVLQLENTETRVNDALSQLGRETRMRKEPQARVSQLQTQLDDQKSATEGSQTEKLEESHHAATDNGMSRLPQKEDRKPRAHDKEPDKASRSCHDKAAPGSCSGTHEPRREERSQLDDECASEALEWRPTLGNKRRQELGKSSREMGSSNKEEFKQHERFREAPNKSRCTFLYGDRNAFRMRHTTLRTVKWNRLVQYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYI6</accession>
    <name>A0A9D4PYI6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029706"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029727"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030363"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="708"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1355" mass="149626" checksum="D13D90D83EB367CB" modified="2023-05-03" version="1">MAAPQQLRPLTFYGRVPKGTTNVDICKELVKRFSPNELKCVQDFGAGRFEVTFATMAAVERFLDQSVVKVRNAEVKFEYRGVRVKTVRVLGYPADASDSALLNGLAAYGKVLGMDYEHVPEFKTVLTGNRRVRVEMARPVPNLLPVGSRIVQCEYDGVVRLCRRCFFPGHHAADCKVPQCERCAEFGHARCEAVCKRCGDDHALSACKVRTYSSVAARAPARVSSSQVTSGAAEGQEAPSKGPEGSPLPETEPVRAEAPGGGEQGTRPELAEASDPSAALPPPAASTDVPAAPADLPADPADAPAAEEDQGETMDAEPWRLVRGKRRRARSSDSSDERPAEAACGGPGGSEEGLPGVKRTAAADSDSESTQSTVKDSTEGETSLFSSSCPYCGLGTCDGDCSPLSDRVYSSTHEDSSSDEEIRNDMDREGQPIKDRPLLCLAIPRSQHALLLVVFFRFEFADSNLVAQGKRPWRLNPRLLKDEEAAKDVAGLLCRSLLGGQDLGGSEWDAVKASVAECFREWGKRRAREERAEIKIVSDAILLLSKPLSGGPGVTAALTSLRKELRVLLQRRWDRLRATARAEQWEMEAWCSRNVLRRHLARKRAVMTSLTDPSTGNLVETQDGVLELARQFYKNLYAKPPSSPYSFPFVKSYEQVDICDSPLVEEELLAALKSMKRNRSPGSDGLTVEFYVKFWKVLGKPFTTLVNRLLREGTLSATQREGLITLLCKDESRRTDLRAWRPITLLNCDYKLIAKCLSVRLTPVLSTVLGPYQACCVPGRSCQLHGFAIRDLIEWANARNLSGILCSFDQEKAFDVISHRYLFKVLREAGFSGQFISMVRALYSRPSSAVVIQDRISEPFDVGRGVRQGDPLSPALYVLAFEPLLQRLSSDNSIGRFPLPPGSPPVALFAYADDLSIVVPDEATVCTVLDVMEGYCSASGARINRSKSVVMYLNSAPSSPRPVHGLPVQQRLRILGFHFEPDGLTTENWRLAKQKLTDRIQEISALGCPLTARVTIIRSLLFSFLTYVASVMPVATRTKLVLEGLLFRFLWSGSSMYVARPVIKLPRNKGGLGIPDLGIVATALHLRWTRVALESDMLLTRSFASFFLSTRLRLFSPEAFSNSVPRAGTPSPFYAGAASTLARLRDANPGIELDSLELHDLVDLLTPDLPAHCVRYDLSRHSPNWKLITASFLDAKRATFMYRMARGCLPITFRPFTKIPTRGKCPFCGSREDLVHIFSQCALPAALLQRIARLYGHPGVPFETVRFLNPLPAQAVNQYVLLLVECSYQVWVARCAAVFDGRRPGLHEVLAKVRKEIWFVLHRERQRLGVKKFLETWHRPAVIFSESGGQITITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYM5</accession>
    <name>A0A9D4PYM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_012786</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034770"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7956793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="213" mass="23825" checksum="429767AEB0CB25F5" modified="2023-05-03" version="1">MNPLLPSGYDFEIIVIDDGSPDNTLEAAQQLQKIYGSEKIVLKPREKKLGLGTAYIHGLKSATGNFVIILDADLSHHPKFIPKFIEKQKEGNYDVVSGTRYVGDGGVYGWDFKRKLISRAANFLTQILLRPGASDLTGSFRLYKKDVLQKLVESCTSKGYVFQMEMIARARQFGCTIGEVPISFVDRFYGESKMGSNEIFQFAKGLLYLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYS2</accession>
    <name>A0A9D4PYS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Alpha-amylase</fullName>
            <ecNumber evidence="6 14">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_021103</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="6 14"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034012"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0868">Chloride</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="16">
        <location>
            <begin position="487"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="17">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="637"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7957662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="723" mass="81854" checksum="BF32478668F49221" modified="2023-05-03" version="1">MGDRTTIVELFEWAWPDVAQECEDFLGPFGYGAVQVSPPSENAFLLYTTPGGVSVRSWYERYEPVSYRIASPSGDLQEFADMVRRCNESHVRVFVDVVLNHMTSNIGSGYGYDGTEFNSEAFAYTGVYSARDFHSRADCGTASGLVEDYSNVVQVRNCKFRGRADLNHMLETVRSSITNYLKQLLSLGVSGFRIDGADYIWPSDLNVIYKRLKEPDEAKLEIYESEPAPYRMAETQLDKYEYIGAVTNATFFKTYANALNRVRERPLKSLRPFIMEAKGAGEAAQVVYVDSHETQRGIDVTDTVGDVVTYRDRKRHVLATVLMLAQPHGVPRVMSSYALDGKFETYVPPKMLGPPFDHMFNTQPVLMRENFECYNGWICEHRWLPIRNMVHFRNWVGAAAAVNWWDDDADAVAFARLQRGFVLVNNGLSVVRGLFNTTLPAGYYCDVLSGSRRDTRTCSGHVVRVRPDGFAELSVDPAAEVPAVALHTQVMKPLMEKRRRARINNCLSELKRFLMANDGGTFEKQSSRSQRVEKADILEMTVKFLRQRQLHLESDDCQKPYLRMPCAYDLADSHEEVERTQRFHDGYRHCVFEVSRYANAMEPRLRDTLLTHLQSRLHHLSASTGGTGMQPAYADEAVSSTNGDAPDLQPGRPARLHDYGYEAGSVSDASEEESSSSDYGDVASPDAELFLRSGCQDEPRDYRLHRDEGLDHDGSNEPMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYU1</accession>
    <name>A0A9D4PYU1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_021899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYU1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041535"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="85"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="437" mass="48033" checksum="79CE7D3172093A59" modified="2023-05-03" version="1">MVWEIAPNVVIPEALTESGPVLTSFHRAEDTKEAVETALYAILGHGAFQRRIMTCSLLSMVVLLCHSLAYRAIASPVDHWCARPATLGAMPVQLWKNVAIPVYPDGSFSRCTVYDPPLPANDLLDENRHPVPCESWEYATKFRNRSIVSEWDLVCQRRRLVQLSSAAYMAGAMLCVPVVGLLSDRAGRKPVITGSVSVLILAAIVCSTTHSFIVFVLSRMIVSAMSSAAQVLSFILLYEVTAPDRRAAYALLATATGIMLMPVVLELVAAAQFSWPATQLLLLMPTVSLVYSHYLLEESPSWLLATWRLKRAEEALLVAARRNGLAAHKATRFFKKLKTEMRRHALAYQIPTGPDASRNARKKTAAGNSTAAEFLSDRRAMCVFLAWFTVMFCYYGIQLADQDVEGGADVQLGWDDVAYVVALAPLIAGTYAGIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYX1</accession>
    <name>A0A9D4PYX1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYX1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="17820" checksum="0B1C6A4523555A78" modified="2023-05-03" version="1">MQAIKLNFLPPQQPVDLGIIRNFKINYHHRVIETFLILIRQNKILKITLGMAFMLRQMNGLTIEHEHTASELRQALMATPAVPVCNEHQLAFVRPLTIQMPATVTLPIVTPLPRLEGKDVPEDIKVNRVLRQMHPQLQYLAAGSTYPSLEALADGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ02</accession>
    <name>A0A9D4PZ02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_022664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ02"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051364"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038432287" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7957782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="624" mass="70922" checksum="0132CB134D35E32E" modified="2023-05-03" version="1">MRLQLVLVCVLLRFTVQCVRAQQDGTNVTEKEGGSENAGDELDYLPLLRNALAGGFANMPVALRRKLLSADVTPECNAGLLRTMRAFQNLEPWALRLLDASGKFPTGLLQGSRVDLGAFDECLETEVFDSYGDVITRGQYCNLLVYIENSTAVEGKIDSFSSVLHPKLKYFKNYFSVEELPVVRIAMCFVEECTQRDLQALVDAVKPRLVRLEVSNCVTAQVEPWIFMLCCFFMACRMFLCILLVIILAATFTDRVMKLKPKLIEKHGALSELTKGFSVTSNTRMLLRVADKSNTEHYSLQFLHGMRFFCIVHIVLCHSGQTLSDNWSRYLNLLIASDEWSFMIFSAGFSSVGTFFFLSGFFLSLTVRRQTRSGPVVFIIGVIRRFIRTAIPLFFIIMCLHLMPRFVFGPDTKSFFHKLHEDVAHHWWHLLLMIRNFVEITAWDVLPHVWYLSTDFQLFTISLVVLLAFKSRKMLAVGAFLLLSLLGCAIGTWAVAGSDLLPFMIFPGPILQVMSKTVNEYYMRPYYHAVCYFGGCIAYLLIEDFRQRKINKFTLLFAFIVWCYLLAYLAFLACEAPTGALDKFIFTRLIGGGGNARKQEHRTQQNGGDVKPQIKIDDSVFSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0B3</accession>
    <name>A0A9D4Q0B3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0B3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034086"/>
    <dbReference type="OMA" id="DINMQIN"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="15089" checksum="EDCEFD1173294701" modified="2023-05-03" version="1">MELGGLIEEVYDLIKDIRDPEKPHTLEELGVVSEEEISVSTDRDAYSYVSVTLIPTVPHCHPRCDYWTLCEERSSEENLPYSFKLDIFIKEGSHTTAAELSKQINDKERVAAAMENKNIKDMVQSCISYETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q288</accession>
    <name>A0A9D4Q288_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
            <ecNumber evidence="2">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_019940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q288"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046522"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038350577" description="5'-nucleotidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7963188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="14696" checksum="8CE22A119393A779" modified="2023-05-03" version="1">MHLLGILVCVFLVFSPRVKELKKTYPNTIFVNAGDFFQGTAWYTVLKSALVSEVMVEMGYDYACLGNHEFDNGPKGLAPFLEKVSRSTLKIVSCNTDFSRSSSLRHIDVPKSIMARMQDTRIGIIGAVTQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q289</accession>
    <name>A0A9D4Q289_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q289"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030802"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000041">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="207"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7962665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="425" mass="49371" checksum="E10A76E75C13ED8C" modified="2023-05-03" version="1">MSDGEDDFMCDDEEDYDLEYSEDSNSEPDVDLENQYYNSKALKEDDPMSALVSFQKVLDLEHNDKGEWGFKALKQMIKINFKLGKYEEMMTRYKQLLTYIKSAVTRNYSEKSINSILDYISTSKQMELLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYFDRNEFNKLAKILKQLHQSCQTDDGCDDLKKGTQLLEIYALEIQMYTAQKNNKKLKKLYEQSLHIKSAIPHPLIMGVIRECGGKMHLREADPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDISEFELILKTNRRNIMDDPFIREHIEDLLRNIRTQVLIKLITPYTRIHIPFISKELNIDSSEVENLLVSCILDSMIQGRIDQVNQVLELDSKGQGAARYNALDKWTAQLGTLHQTIVNKIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3G1</accession>
    <name>A0A9D4Q3G1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_015885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3G1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035721"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="13">
        <location>
            <begin position="133"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="14">
        <location>
            <begin position="486"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7962396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="563" mass="62793" checksum="91AAAC5638F7B338" modified="2023-05-03" version="1">MGFSPQSERDFIKLDLGPELEKAGYGPNRLKLMILDDNRIALWYWANVVVAPKCQRRDYGRGSYVCVCNVTYCDYIGDIAPLQNGSAVAFESTKAGLRFAKSVVPLGRAPDDGNSNKTLLIVIDSSKEYQEVFGFGGAFTDAAGINVKSLPANMQDDILKSYYAIEGIGYTIGRIPLASCDFSTRKYTYDDSPGDLELTNFTLAQEDFDLKIPYIKKALSLSSEPAWFFGSSWSSPAWMKTNNELEGRGFLIGEPGGPYYKAWAKYYVRFVQEYERLGIPIRGLTTQNEPTTGFVPGFRWQTLGFTVNNQRDFVKLDLGPALAEAGYGVDKLQLMILDDNRIVLPHWTDVVLGDPGAAKYVSGVAVHWYMDSFIGPSVLDKVHESFPDKFILGTEACTGAAIKPENKVKLGSWERAELYARDILEDFNHWVSGWTDWNLALDTEGGPNWANNFVDSPIIVNASAQEFYKQPMYYALGHFSKALPRGSVRIHSQLEQPSFQVAMNTTATMLEYAAFKTPDSALVVIVLNRDNNEFTLKIKDASGTGSVQKVIKERSITTFIWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3H4</accession>
    <name>A0A9D4Q3H4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3H4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="22336" checksum="A169C97620B0FFE7" modified="2023-05-03" version="1">MSSSSLSNNLQYHLSLASDGDRYDWAAQPDSWGLDHLPIIITPAGGKVPRARQCSTVEWRAFRQQLQDAPEHQDFLNLMAAAAQAATIQSCVSDNHPLPEHLHLNLRAARRRAERRYLKAQCPDHRPLFNPVDAVYRRHANRRRRQTRQDVAQKHGGVYGLSSSGQRGGNPGLQWPSDSASVIKNWQNGWPIASRHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q551</accession>
    <name>A0A9D4Q551_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q551"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030087"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040246">
        <property type="entry name" value="C16orf87-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31101">
        <property type="entry name" value="UPF0547 PROTEIN C16ORF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="19674" checksum="9F7B032F0433DD2D" modified="2023-05-03" version="1">MRGLERKEHIGSWNERKKFRARVPVACKSCPCGHEFFASRKSRGVSEQNSQRPRRRTERVRKERQSYLTALVLEQRAAAARAKRARRNGNRRGRPPANRSSSHDSGDEGRKLNRPRCGPAKPAKPVEPEMPDEEEEDVFAGCTQERLELYATILADINRKLSSQLFHQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q666</accession>
    <name>A0A9D4Q666_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q666"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044748"/>
    <dbReference type="OMA" id="DEGFFRN"/>
    <dbReference type="OrthoDB" id="6480055at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038932443" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14107" checksum="EC44CF1E98EFE8D1" modified="2023-05-03" version="1">MTALSATSFALVLLLGAFFRESSADEGFFRNRGPMPESLQALLHSEGDTQVLGKVDSFKTSGGSVNAGAATVAGELELPALAALPQHDCHIEVQVTERVRGHCSALTLLGKSFPVCKNGDRISVNNHECAHMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6K9</accession>
    <name>A0A9D4Q6K9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6K9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049795"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76571" checksum="27C81320B3E54EEF" modified="2023-05-03" version="1">MSGANSFNVVEDVSASDQDLRVLRASFDNAVDAEAWMKKYSAESRTSWILSSALRGGTRMVYHKRWVCHLSHRNKSRPTSLEKPACPAQLSIKIKKVNRNTKRNDTFLRLDPPLPAVIRLISQHNHRIECADAPMSTRPTPETRLKFEGYFELGMNPSEAKRHNERLLLAGGNGSPTGPANPKLSCLYTWYREWRIDKYGSPENPLSKLTEKATAYATSGADIKLTGTDDSWAVLLVTPIMHRAQQIKSSGDLIFVDTVSSCDATKSMVTLFLTATKAGAVPIAAFIHKQQDTEGYQKAFDLLRTDYPLCFGNQQVLNAKSHEELARAKEELCRSNHKVYMEQAGAFFAREREWSLPSRVSLTAENWDVAAYSEVSVRILRDFLLSKMQLYNAVALLDFIASECEAYLKARILQHSRPVSYADYQWGGSCTTSLERLLSRTPGASLGSSVILREGENAFSFRNAHNRRECAIQYDLGLCSCWPGSQGAFCKHQAFIVHEFKLPFPCTPELTTAECEELVTLAIGRRSLSPTSSPNHQTCNLDSASNGGEEDIWALLDHDYIKEASGDAGDSNTELPRLDILESACVEISQDEALVTEEQSYQALVSSLRQVHELAKDVPGYVGLVDRIVTEVKDLTTSHAAYGFLLRLDASATAERRRVLAPPIKRPRKMIRTPVRSKTSTPSIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6L1</accession>
    <name>A0A9D4Q6L1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6L1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053021"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="76" mass="8547" checksum="C090A339C54B6A63" modified="2023-05-03" version="1">MLFVRCSKRSCHIDAGLNRGCDYKDIMDAVEENKFWKSRDSPGRRRRSIEEKAAKAATSSQATQDAVVRSVQQAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8X2</accession>
    <name>A0A9D4Q8X2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8X2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035909"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="315" mass="33939" checksum="57CB4DDE272648CF" modified="2023-05-03" version="1">MFHVQVLAATAATVADAESTVRSLTNEASQRRSTSDASGDPHRQGFEALRLQDTVAALPSGFEFAEAVAYDAMNAPQAAGGEARLGIGVPSQKLYQTQNGGAFLKPNGERYHASATDHYGGLGGSGGSGGYGFPDAMRYYHYGSGPKAYNTEHAYAYEKVYPERTYSTNHATSYEKHYDDNDNKGGPWAGGGYESRFSSSYPIRGGGGGGGYGYRHGDGYGKGSGSGYGAKGYESRYDSRPAAASSTRSRRRGGARAGPKIKRYVYKNPYDKSTTRVVEMHSSRGRPSWAASNENRQIWKPDDMEQFVLGLMRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9C4</accession>
    <name>A0A9D4Q9C4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="5 20">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HPB52_002376</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
            <tissue evidence="22">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="5 20"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9C4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030892"/>
    <dbReference type="OMA" id="HTAWEPT"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="18">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="18">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7971719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="340" mass="38601" checksum="1176F567DB0561EF" modified="2023-05-03" version="1">MVAQVCARNRFLTVAVCFIVAWLVVQLITTQQCLNQSQTYAVSESWKHSCLRKIVDSLVSSAVHSDCIAAVEKLADGQRQRVIYAVTPTYARPVQEAELTRLCHTFRLVPYLHWIVVEDSTVRTAVVSDLLARCGVAYTHLYAATPADRKLKPDDPSWLLPKGVLQRNEGLRWLRNNAQQLHPSGIVYFADDDNTYDLRLFDEMRKTVKVSVWPVGLVGGLLVEQPIVKDGRVVGWNALWKPYRRYPLDMAGFAVALRLLLDNPSAQFRLRLPRGQQESYLLKQLVSGPEELEPRAGNCTQVLVWHTRTEKPKLDQERRLSKTGHAKQPKQAAAKQRPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAT1</accession>
    <name>A0A9D4QAT1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAT1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031846"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043456"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52087" checksum="D6A555B4D3F014DD" modified="2023-05-03" version="1">MQWIADQLGFFPEQQTCIRRHRCTADSIADVVATLEDVKSCGDVAMLLLVDAQSAFDGLPHVVAALDTVNSFLGGIGLNVSATKTEALLIHSLAAARVHVKQLRAATTKVRRVQGAIGKLQQRGRGCSLKWALRLNQAAASSVMLYALPLVNLTPAGWNAQRSREGHPGAPQVLSCCSYACGGGRVAPEATHIDCLHHAADGAALLERLCSLPGSRMGGLVPLYHQMVPDPPAPVASPPPHHRPPEQAATCKLQEQLEGRLQVFTDGPMMPGGTVAASYVVPAWTSSRQCKVPFPASSAAAELAGLQILANHRGTGLTGSLLAAKYRALAASGTSVSFHWLPSHVGIAGSTPAWHSHLKARLKKLLVTVHPDSRVANGRGPRLLPETGLSRRDRSALLRLQTGCVWTAACRHAKGRCASPACSRCGDPETLEHLLCDCPALAQERSRVTTAYRRQDLPAFTLEQCSSRPVPTCQHSGAWWSSWTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAX5</accession>
    <name>A0A9D4QAX5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAX5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027250"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="18840" checksum="C4027601EFC4C84D" modified="2023-05-03" version="1">MPPSGKRISNNRSRRDKQHGDDECEQDDQVDRVVAVHVARWVLGPLLYGAEQRLLRTDSIAGPSSDSASSSSVLVLRVQCHARLFGLNGSTHAGHIRTSWGGVGRNVADCLSRLLGDTVRLVSAVGVDRNGEALLKHNPLLVSLASSPPPPHTLSRATESVVPDSFYRTLKPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEE8</accession>
    <name>A0A9D4QEE8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030157"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043760"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="834" mass="90539" checksum="771F916FE4606CDE" modified="2023-05-03" version="1">MEALLRADPGPDPRVVVGPNRGADLARGAGLGTRKERSISRLSGSPSPQPTEVFMVVEAGPSGNPAKRKAVSSSVENVQAKAKSEIKETLNSIRLEIQRLNERLSVMDQRLTVMDRKIDAQNVLQGSDADYLWLEEVHIDGAVVRRWLRHMMTGSEPTATMDDVYVLFGALLCNVNSKEGTNINQEWFQYRVNDLVALFPAVSEPPPVPLYSEAQAAALSAFEEQCPFTAAHIVCTIVEGRCLRPLQRLQEYVCEQWRITEMIQAQKQKVGECELEVVQQAQESAKSGPPAEQRRQEVDASMVPVESRIPVTRGVPETAKCDNAAVSQPLDVAVSGPPVVQQPCEAAIQESPAVQEAQRVSIFEPPLVHLVQEVATSESPLVPQPVDFARSKPPADSQPRKIYRFMTTTVPRLMVYAFPRRMGDFDPNWIRLLIRGGNLDTTVACLLGFIKFFCKADYYKLRNTMSGSGCAATMDDVYVLFGVLLCNVNADGTDFHQEWFQKQVNDLVALFLAVSEPPPIPLYSESQADALAAFGQQWPYTAAHIVCTIVERLFKGFEQPTTSSRPLLSQRCYQAPPTPYPNTSGHTIIFRPVGKKTHFLAVSRDNIASFLSGFPATRRVRVNYRRNLVAVDTHQASDPTSLLQVAVICDVKANALPSLSRAPRSPRKFSCINKGASFVLASPGLSNAPDAAATDTPRPPARLTSAVFAAVPATPQNPLQRKAAVILASSDGSVTRRQALERAGNVVRNKQGTSVVTKGRSFRDALTGGCASTTTEPTPSTTSAPAPQADPKDVVLAALAAAIRAVLPFVPDDSPVRALCAAALAAHDVIAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEL6</accession>
    <name>A0A9D4QEL6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_000008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEL6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045702"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="397"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7975293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="690" mass="76327" checksum="7248AE8B206FDB9B" modified="2023-05-03" version="1">MEGEQTSLSCPIDMLREPLSAIWFHVSGIASDSSTALIGAKQKEPKKVYALAAPVSTQRVLAASVSLVDGSHWKQPRWKHRAFFSLLSDPPALRLNRLERTDTGSYVCNVTYRDDNATTGAVTVTEAHFALFVAADHKVTLTWRRDGEPLDSPLGTVSTHGGQRMAVLTLGPLRREHLLSNISCLATSDVTMPVESWVLMDMYPGNSHLAPDFYAPRSFECAVTGSRPHANVTWFLDGRPLDKHLSVTGVDANATTSVLLLPALKHAGKLLECRATNDRLQRGRGILSRYLPVNLSDKPEVNLKLGAGLNASHITEGTDVYLECSVLAASKVSEVTWRHQGHDLAPAPAEGMLMTSRYLVIRRITPNHAGSYTCSINKAEGDYIESAPFQLRVQYSPRCDQETEQAIEVERNATVNVTCDVRANPNHGLRYFWLIENASEVADRAKEEPQKFERKDVPRPQVTDSNRLEIIANASLFNAVLSCWAENSVAVQRRRCSFKFLARGEASSSGITCVIGNYTATSFSLVCSTPIGEGNDSTSRQHRRVSVEVLDSEKRNRSERSYWSDDWSAPMFVTGLRPSTDYLVVVRIPPKAIFRTYVRTLSPAQTLKEREDAKTTTQHVQRTLGIVLVSGALLVVSVAFVGVCFVHVYKKRRKRPLPAIRHDSASIKPGSSDSMYIRDEASYVATAEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHF0</accession>
    <name>A0A9D4QHF0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHF0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="10804" checksum="52DE54576F1E23EA" modified="2023-05-03" version="1">MSGGLTAVLRLGDRLVGSASSCRDRSACSPLNEGKLGLAATGSSRKAPKGLRGPGVPGVSAGTRLTLPELDDTRVPRLVCEAPSDISGVATTDRRNERRSGVSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHV8</accession>
    <name>A0A9D4QHV8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHV8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052912"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9570" checksum="3B533E82CFEBAF64" modified="2023-05-03" version="1">MKKKPFKGYFRAFLCGRCWSKEGAADKQCATRSPHGQLRSLRYSSAKATQSFKLNSFPTRAASVDRRRVTCRNGAAAQPSGLAINDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJ45</accession>
    <name>A0A9D4QJ45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJ45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037658"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="17754" checksum="554FE72052FFA9DD" modified="2023-05-03" version="1">MAPRDGNGVNTPKQLLWNAIPTLFPLPLKPEDNVSEIAESRTALQKQSKPPSQEAGSGVEENLNVNPGGRVNVEDYEMAALPTFGRERLLAIAKKQWHEIKRLRVNVRNLERGLASNLVLDETYLLDLLQRNLDGQLLDRVVDIIVGDVDDDHCPAAVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNA2</accession>
    <name>A0A9D4SNA2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_021539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNA2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7936333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21317" checksum="A2BDAD55B4C9BAB7" modified="2023-05-03" version="1">MPNRCCVPGCRSDYKGSKKTSSSTRNGGGPYRCKKAVIINFVSKYTRVCANHFDASDIITAYDFDINGDSVSQKRDKPTLKADTVPRIFEGLPSYLTKRKPRSRSSTVRPLCKRPRESACEDVRASPTPCLDRTVVRVVRKRLARKGPTGSVTARRSPAKCCTARPCRLDENKSYRLYARVKAKHYYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ60</accession>
    <name>A0A9D4SQ60_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ60"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053185"/>
    <dbReference type="OMA" id="ESCEYGT"/>
    <dbReference type="OrthoDB" id="6516516at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="52769" checksum="0F6FEC03E3DAF79E" modified="2023-05-03" version="1">MGPVLRQRPRPAGAAAQPRAVSDPSTTGDTSAQQAGTPPSATFASLTNTALGQQSHEPATPAQPNKPIHERESSQTSTSSPAATEETDASTASSSSWEHATPPSSPATPVASSEAGSSRSFTASPSISPLSAAVTAAPVLPAAAVTGPNTPAATSAPQGFEQPTTSSRPFLSQPCDQATPMPCPNTSGHTIIFRPVGKKTHFLALSRDNIASFLSGFPATRRVRVNYRRNLVAVDTHQASDPTSLLQVAVICDVKVRSKILTPNTCVGLVFGVDPRFDAEAISANICSSVPVTSCVRRGKCLTITFEGTTVPKEIFLYKQRRLVRPRLPRPLQCTRCGRYGHATATCSLDERCLRCGASHAAEPCTAEQPRCINCNGNHASTDPRCSSWQLQRKAAVILASSDGSVTRRQALERAGNVVRNKQGTSVVTKGRSFRDALTGGCASTTTEPTPSTTSAPASQADPKDVVLAALAAAIRAVLPFVPDDSPVRALCVAALAAHDVIAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQJ9</accession>
    <name>A0A9D4SQJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045497"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="673" mass="74828" checksum="D39A49EB36FF1877" modified="2023-05-03" version="1">MGSLLMYRGLPGGPTEVKFADELSRHCLCSQCGMITLSMYQDPNDHMFCDTCLHERSTKYGKFEIFCTYERKNIGINEMFEARDLITILRDQYVDCPNKPHCKEKVPLENLHRHIQECNKNPDNVPECNSAAPEPGAINEPPEANCSARTVFDTNRDINIGGGPIWMQYFASGDWLGAFVAMEESFRDSVLDQQDRYARFAPALVSLEQYHCVEDFLAKPSPVQPYYCLLAALLVRKYLPRNVWSRRQEGTWMGALQYMPYFLASELSDEAIAYLCAFPVFLDEMGCQDVGANAPSVAPCQPSPKPGPNGVSEKPSSGEAHGGVNTTETDTPKPDLEEDEDKASAKLKTDERARNEDADRTVYLNASPEPSMRSSLRNQGSSDSITNATASSKRELLLSAIAGSPRRHHGLLPNASESSTLQEYPVNTNPTLDGHATRDSYHQAQELDDTFSAMSTKGRLLSRALLCIERMCFLATSGKRLRPGVANNKTAGAADEQYHVAIGVPHEVKGHRQQPGSTDVEHQRSPLAADIPVLPVLDVRLGELLVWYYAVEEYLAKLGVFDDTEKFQRMTSFLSPSVLNQLDDILTLPPPTHAYECLLIAVFKRSKSARDGGEGVVSGDEFLEELPYELVMKFSKVDAAVNEMNPPPFSGEEHGCCACRDRERLFGDTDTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRF2</accession>
    <name>A0A9D4SRF2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_018984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRF2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030495"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF410">
        <property type="entry name" value="BAR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G11475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7944395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="815" mass="90089" checksum="13F8D2FC2CF377B8" modified="2023-05-03" version="1">METYQSLRGKHGGIIVHSLMKLHRFTAGQPYVNLEQLNEPSEVHALATLSEKMAANEPESDVQMRSREESQSFRARVQFRKSHSGPPKMEGYLRKRTAKLNLKWFWRKYWFVLDGRSLLYFKSQSNYNSLGTCKGLVDFGLVQAVRPSHGSKNTYAMEVITRSDVIHLAADDWQTRQVWVAALQAAIQISEVSWPFKVQLDNAPKLVQIQRGEAPNASSASDSEGRHSRHNDRRRKTSSLIIYENVSIETPTRNNESSSDRRPSSEGAIYQQISEAELKAHDCEPRTSDCNAFGKDHPCSQTKKDKGYGGMLRRARSFSCGLMSAKGRLPGFHRHRDKSSKRGSKDSPSQKHDSTSGSPAPTPDSNRVSKEARTASHRKQDSDGSVRSAELFSRQTSNSSNRTSHKKQGSTGSAKLDVTMPAAAVRNRIASSSSRTDEHRITACLDVNPTYQTAAESRADGFATEPATRKRYDSSSCRRDVVDDDDFAPECPSRPHPASPMPRSDASAPMPSFEYEHHVPPSLMGDKVGDDERQRKKPPNLRMNPMAAMIPNREYAEVYEDHVLPSPLRRSADDATRRGTTSMGHTMIQAPSSEYAEIDEGDGGSSLSRTLSSPPCSGRAPLARRPSNPESSVSRKTSKDSADDSSLHIYQEVRGLSRSPSPSPRTVFMASLASSTRPAEMDDEEESYYSSISEEDLRRYQWSSDLARVGETSETGTESSTYNTADASGSSEALAETGYMEDNPHITVTTTDSNHSSGGSSGGRIDTAPPSEAMRELRELLDCLGTDDDGNMLTGQRSIARARQLLVREMATNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS84</accession>
    <name>A0A9D4SS84_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056195"/>
    <dbReference type="OMA" id="NFFDECW"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="81142" checksum="8FF81F79B82055FF" modified="2023-05-03" version="1">MPRHKRGSWGSSRRKPSALAVLTKSYFSGSSINYRTRCTSGEGRLCDIFQDLHLWNEYFWQAGHELRELSPGQLSLVEMHGAYVSLEMPERKREAATLLYHLLTLHRCVVSVEMNGYIFRDHHRLICDALRKSPSLRKLKLSLLTVAEHSAQCFAAALPFMNQLRELAVSQVHFDDVFVEGLSEFLASTRSLTTFAMSHTHIESQYTRAILRGLERNSTITSLALNTLIMHPDTSPSGSIFTEYLRQNRTLRTLTVLSRYLNDHAKLRQIIGALLSNDTLSELNLLHFSLDNENIGLITTLLAKSRTLRSFNLVDCIWNESSSQRSMLHMENFGKVSSRIHPWLVALTENKTLVELTLDLSCFDSDECRSFIKALASSTTLKQVTVARLRSEDVAEICLAMREAGMRQRFFLGTHQAIKDPVVTLTKCKEMSCVSFDSTELDELEPLRTTLSLLPSCSHVTSLCLRLSLDLLSSEVSTLIAQYITGTTVLRELTLSFFDNGAGDIIYGTELALVKALSANKSICRLSVRGLCFHENEIQMLAETVRSSRMIYDLAFYPDNYESAILLLSKLSQGICSNYTLLYMLLSQRRELGKDWFTIVDVKRRNLALVTRAAHFVMGTRYKYCAEAAELVHFNPGLVEKVQELASVDQNEAVSRIRSSLKSFSELDDFMRVAGVVKYGVTCHKRSDGRKQLVDIGRDCWLCIRQYLKVGDILDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSB4</accession>
    <name>A0A9D4SSB4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_010029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050438"/>
    <dbReference type="OMA" id="TEDNMFF"/>
    <dbReference type="OrthoDB" id="6496561at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7947311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="266" mass="30613" checksum="E147B2CB16780A96" modified="2023-05-03" version="1">MNTSASPLHSLHEHYVLLADPRTRTWFFMGSPLPVMAVIGLYLFFATRVGPWVMKDRKPLNVRSIVVFYNVVMMGLSVYFIYFALSYASMRRPNQSVFCWASDPRPTEDNMFFLTRAWFYMLMKAGEMLDTLFFVLRKKTNHLSFLHLLHHSLALWSVWLVLTLGMTGHVFSFPLLNSAVHVVMYGYYALAALGPALRPNLWWKKYVTLFQIAQFVVLSLHALIPVIQDCGISRILAFVGALEGLLFASLFSDFYVKTYVRKSAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUA7</accession>
    <name>A0A9D4SUA7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUA7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041851"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="46"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7951098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21814" checksum="D07BEC17AC4BFA79" modified="2023-05-03" version="1">MDSGAVLLNVSRLGNEYSLNGYDNLALDLETKATTLNGTPSKILVENMSGEVRSGTLTAVMGPSGAGKTTLLNLLTGFYDKGYAGEVHMNGYVRERELFNKQSCYVMQEDRLLPVLTVCEAISMSVELRMPNIEPKDRAKKVEQSIHEWGLEECRHTITENLSGGQRKRLAIAQELVNNPPVVFLDEPTRLSHVQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWA2</accession>
    <name>A0A9D4SWA2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWA2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031713"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12120" checksum="B79B9D50EDBB87DE" modified="2023-05-03" version="1">MGLVPAGTPGTSQLTLARAPLAWLTGGRKPGLVRGRRPPNGKDPAPVVMDIEVRPVSRAGSTSQRWRTNAERALTLVFPNLPSTERRLDLRSTLNASRLINHRRLAECRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY18</accession>
    <name>A0A9D4SY18_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_007779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY18"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034841"/>
    <dbReference type="OMA" id="KDMLDPW"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7956273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="25957" checksum="C549D72AA3BE0717" modified="2023-05-03" version="1">MAPVLGYWDTRGLAQPIRNLLVYKGVDFTDKRFKFGPPPDCGRGEWLKEKYTLGLRFPNLPYYIDDDVRLTQTLAILRYLGRKHGLTAKNDKEMVELDVLEQQARDLVLILNFAARPQPRYREGLSSYAENIKDMLDPWSRHLASREWALGDRLTYVDFVLYEGLDWHREFKPEALAKYAPLVDYLRRFEELPNVKEYFASDKYKKWPITCPARPWGYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T059</accession>
    <name>A0A9D4T059_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T059"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051560"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11332" checksum="04E741A78ABC1083" modified="2023-05-03" version="1">MDEGELTDSQQPLWSPLEGNTDPVEAVLPFLTSSLWQRSLGRKLQLQGVTTVGALASMTCAQALQLPVRAPRVASLRKALQQYAAALQDSPLCEASLLTEVFHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1H5</accession>
    <name>A0A9D4T1H5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Adaptor protein pacsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_005525</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1H5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07655">
        <property type="entry name" value="F-BAR_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11843">
        <property type="entry name" value="SH3_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="137"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="490"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7968040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70673" checksum="917DD1F5DD4336EA" modified="2023-05-03" version="1">MLWTRANAALNHPEAFRVHSLCYADYRPTGSGAGEADEQSCGFSSRSAVGFDLFPPRGSKRRAIEHASFRAEEAASLTDGYVIFILLTPDDAFAVCAPRRERTAGPHVPADLEWVVLVCIAGSVASMSQHSDEALLVAGSDSFWEPGNYKRTSKRTEDGHRLCSELIQLVQERSEVEKAYAKGLRAWSRKWAEQIDKGPEYGTTEAAWKGALQEADRTSEMHLRVRDKLLNEVVPQIKTWQKENYHRSMMQLRERRELDEAFKKAQKPWAKLLDRVNKARSDYHTACKAERSATNQERNAGADSSLSPDQVKKLQDRVAKCKEEVQRTRERYEAALQEINDYNAKYMEDMTVVFDKCQEFEQRRLKFFKDMLFSIHGCLNISTDPELPQIYEEYRHTIHNADASKDLKWWSNNHGIGMAMNWPQFEEYSEEFRDIVGKSSKKAAIPESGITLVNQHKIGEELPEYTPEVQHIHRKEKKGIDSGGITLTSVSTRADGVVPNAPKNQSTNKGPKETGTNHSTVATTNNSTPPTGTTNTNGRAGEANPFEEDHEDWDEESNDALVDNGEPGVPVRALYDYDGAEADELSFKQGDQFEKLEDEDEQGWCKGRKDGRVGLYPANYVEVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1Z8</accession>
    <name>A0A9D4T1Z8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_009580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1Z8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039926"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15060">
        <property type="entry name" value="7tmA_tyramine_octopamine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002002">
        <property type="entry name" value="Octopmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00664">
        <property type="entry name" value="OCTOPAMINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="66"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7968550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="411" mass="45922" checksum="509A99CB13DB420E" modified="2023-05-03" version="1">MDEDDGVLWTTAPMPSVTAVSEAVNASSFEVDNVVEAFPSGIAMSVQEAVGTALSLSFITVFTVVGNVLVICSVFNHRPLRTVQNVFLVSLALADIAVALLVMPFNVAYSIMGRWVFGLHFCELWLTCDVLCCTASILNLCAIALDRYWAIHDPINYAQKRTLRRVLLSIFLVWVISALISVPPLIGWNDWPEQFDETTPCRLTQETGYVLYSASGSFFIPLLIMSIVYLKIFLATRRRLRERANAAAKVPSSATRCAATAEHSAALLQERHPSSSEETPPPQHRGQTKESRPSLADTSVTLEQNGRPPSVKVFACWEERQRISLSRERRAARVLGIVMGVFVLCWLPFFIMYVTAAFCDHCVQSDRLVNFITWLGYVNSALNPVIYTVFNTDFRRAFRSLLCSGNRRTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T252</accession>
    <name>A0A9D4T252_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T252"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039776"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="71"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="282" mass="31042" checksum="0F8030911F2A93C7" modified="2023-05-03" version="1">MDDTEFLPSCWGLRLRGQELIDHFIKETARLSEETRSRVAVQKDIRFGEHPRECLDLYHGDRPPGECRSTLLFWHGGYWVEGDRQSHAFVADAFVEAGVAVAVAGYPLAPGATLDQIVESATQCARHVLALRPGPLVLAGHSAGAHLAAMVATRLHGESRLRSLLLLSPVLDVVALLGSSVARDAAINADQAMRNSPLQLVDELPTHLHIVVTYSEHDPPWFGRTARAYREALGRRRISCELLEYVDEDHFSFLLGALRDGAHRVTARLVRSSLPATAPSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T323</accession>
    <name>A0A9D4T323_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T323"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046656"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052740"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="23711" checksum="7FF109DA95AC297E" modified="2023-05-03" version="1">MCDDFSLVAPLMAGYVRDHRVQFYVLDIDHETNTYHLSTRESRIVLEVYFTRRLDGLANCIKQTTLREEQEKLNVWTALLNLEHMYGTRDSLNSVFKEAVQFNEPLKVYEHLAQIYAAGSEREVRAFCMLLSCLQYKQMLNKFKQHADVWLSFGLFYMKCGQTEDCRDLLRRALKSLPSWEHIVLMTKFAQIEFTYGDAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3K8</accession>
    <name>A0A9D4T3K8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_009762</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3K8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028051"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000001">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7972227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17174" checksum="A836B0E45190D399" modified="2023-05-03" version="1">MSVMVSKTALSVAAGVCGTLFIGYCIYFDRKRRSDPQFKQKLRERRAKAQQQKEQARRGTGKLPDLKDYDAVQKFFIHEVQMGEELLAQGDIENGVEHLSSAVAVCGQPQQLLQVLQQTLPPQVFHLLLQRLPVVSQRLADSAGGPPLVEDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3M9</accession>
    <name>A0A9D4T3M9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_013283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3M9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057342"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7968972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16068" checksum="FA900BA1F95EEB7E" modified="2023-05-03" version="1">MCRLKPSLPGIYRKLDHDVVMSGYVVPAGVPIFVDGFVAGRAKENFYRPELYLPERWLKTDQEILPHDGYASLPFSFGPRMCLGRRIAELQICTLVAKILLKYSIEYHREDMEFHGQLINIPKGPADFRFKKVQPEARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3N6</accession>
    <name>A0A9D4T3N6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3N6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="247" mass="26875" checksum="0C5901BAF7299AD4" modified="2023-05-03" version="1">MQSVRDPKRAYVERDVSVTVWNGCPEALVRRLEPDALPSKVSHEPFGVPDVGVELDTEPPSPGILGQQVVSPTAGLATRSLALRLAYAELDPRSKNGTWDCLCKPFCWTPWKALHSKVCTLDYTLINTKFSVLLGMIVVPYNMRDPKRAYVERDVSVTVWNGCPEALVRRLEPDALSSKVRHEPLGVPDVGVELDTEPPSPGILGQQVVSPTAGLATLSLALRAAGLVESWPPLGEENEGVDPSHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3N7</accession>
    <name>A0A9D4T3N7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3N7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053365"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9664" checksum="F998A07B82765B85" modified="2023-05-03" version="1">MGNLRLATLSGYQEIEVRPRKARGRRACPGENMAMVEMYLYLTTLLQQFRILPEDDKPIIITPFGPSSELRDTKLRFVKRTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3V4</accession>
    <name>A0A9D4T3V4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_011727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3V4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053922"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7968848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10064" checksum="49C9D8F1B46E399E" modified="2023-05-03" version="1">MSASISVNVMLPLYTDDSVISARVSSELVGCVGAGSSFSVPESESSQVVLKNRQLKEVIDALRNIIWEINTMLAMRKRHLQFTHRISSQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3X9</accession>
    <name>A0A9D4T3X9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3X9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="13247" checksum="0A0F47EA013F791D" modified="2023-05-03" version="1">MGFMDHFASFDNGRKRDIVNVARLKLCRPRSCLDDDADDESESERECSVRVDTTVPQGGAAVPPASDHGQSEHSTSDTEVYFDPRTQYRDQSSDTEPKRLWAYDSDTEIYYTASDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4B2</accession>
    <name>A0A9D4T4B2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4B2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040630"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7969599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="503" mass="56332" checksum="EBE3026E7CF5F3AA" modified="2023-05-03" version="1">MGTALRNLVEKNKSKDREGRLTHGLIKKLTNYYGWAIKSNPNNVPAMEKAIMATFYHITSTDDEPRHEHCPTGGIVLEVVFPLLCHNDQDDELWKTDPHEYIRLKYDVFEDFLSPVTAAQSLVHMVCKKRKGVLQRAMAFVVALLTSPACSPRQKDGALHLVGTVATLLLKRRMYKDQMEAMLVAHVYPEFGSSEGFLRARACWVLHYFCEMPFRTEANLLRAVELLTHCLLHDSELPVRVEAAIALQACLTCQEKAQATVKPKIKEITMELLKIIRETENDDLTNVMQKIVCMYADDIAPIAAEMTQHLVATFTQVVETGGDGDEKAMVAMGVLNTLDTLVTVLEEQRELVAMLEPTLLQLLVGQVLGQSLLEFYEEALSLLYSLSCRGPLSADMWKAFEALYLAFQKDAFDFFTDMMPALHNFVTVDTPGFVSNENHLLAMYNMCKAVLEGDSGEDPKFHALKLLEVIILQCKGQIDQLPRSAGTKSLGLSDTGCGSTHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4H7</accession>
    <name>A0A9D4T4H7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_023261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and beta chain produced by autocleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4H7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056270"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033345">
        <property type="term" value="P:L-asparagine catabolic process via L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04702">
        <property type="entry name" value="ASRGL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000001">
        <property type="entry name" value="Isoaspartyl peptidase/L-asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033844">
        <property type="entry name" value="ASRGL1_meta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038778">
        <property type="entry name" value="Mtln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22002">
        <property type="entry name" value="MTLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="11">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7973247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38237" checksum="4073583F2A6DEE6C" modified="2023-05-03" version="1">MSVTISGKQLSLLLFVSFMLGVGVGYKLKTLRVHYLKQRRDWLASRLATAQQKLEGMLPVVAVHGGAGKVSPAIVEEKMVALRAAVEAGYTLLQQGGTSLDAVEAAVRVMEDHPAFNAGYGSSLTIEGSVEMDALIMEGTHMKAGAVGAVRTVRNPVTLARKVMEQTEHVLLVGPSADDFAREMGTPLVDNGSLVSAKAKQRLEEFKSFRNTVQHSINVNQKEHDTVGAVAVDAAGHVACATSTGGLTGQRCGRVGDSPLVGAGGFADDSVCAVSTTGHGEAIARSCLAYDMAVRLQAGSSPSVAMEQALQRMRRKMQGGCAGAILVTPTGTVVTGTTTELMPWACRSKRGYQCGSQRDEHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4T4</accession>
    <name>A0A9D4T4T4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4T4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040220"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20115" checksum="2F6C092C94AD1EC9" modified="2023-05-03" version="1">MATFTYSEHDLVQCPYDPDHKAEARKPLGAQAASPRTVLNDVNWPSCAQACQAQTGHAPTRKPWVQKAAHTTNSQPRSTQANQPCSTKANQSRSTQVSQPRSTQPSHSRGTQARQPRGAQAQTSNPWAVHAAQSNQRLGDQTSPTPGRTWDDLFRNTTVSTRSTDMNELAERVKELGFAGPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Y5</accession>
    <name>A0A9D4T4Y5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Y5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16466" checksum="CDF656D89EF4B95F" modified="2023-05-03" version="1">MCGGNDTLDARAVTAALTHIVKEKALPSKDMGIRDENIEEDDVIEELEALREPPRKPPNSVAYSGLVYVDGYIAKLITDVGHSALVKFTRWRGKNSFLSKACFEEVALAGIDRCLKLTARERRDREWRHSTTPSLSSFGEDNRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Z0</accession>
    <name>A0A9D4T4Z0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Z0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054673"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="241"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7970018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="831" mass="91326" checksum="53EAAD09C810DF4F" modified="2023-05-03" version="1">MELSTSSESDASASEVERSQRCAPWLEFGPTMCGMLASLEEQVQRRPQQAATLYRGRRRTFADIDRCSARMAEALRAPPDFAEPADVAACTAAPDDTLLAFLACLRLSACCTPIRPSASNALLASIMEELPPACTVVDNDTASRFAQARDNRTLNINDALQPRDDGSGCWDRPWLRRSPSPSRSSPYRRPLLQILGEDEDGRCALAAERCLGRIQWEWSDNQADRETVAVLDSVDTARFWEDTLSALCAGATVALPTEEDKRSPSALLWFLRNASATRVEMTPDLLFALLRRAALDPGPVLPELRLVKCSRGLVTTQLARLFQRILPKARLMRVYERSGHSFAYECPAQGELRHFATDHGDFVTIGRPVGNCRAAVCEPRLMTECLPGTVGTICFAGAKDDHLLPTGDKGFVDSDGYFYLTERTAPRIDGCKADIALITKCLTDIPVVSDGEVSWERLSSPKVSLVAFYWSTAPGDTSGELFRPLSSKLPGWQWMPLLVPLGPLPADKRPDKRELLRNYADAILKLQSCGEVNVTRAATVLVALARSLGTTVGQLDMDRSYASQRTGNGARSVSDAAALLEHIGYQVSASELSDTVPLRILVERAACTMMLPGMPGARRLRVSLLDADTSFDEVTNLLARSFTSKNRLDQAVHNTEEQHWRSLRHLWPQLIADGATRLVRDAETGKLLAVAACCDFSAPQTAPDGMAESFLAIAEINESMERPLRAAVTALGRRLLLWFMVGTGTDLHADNIALVLLLMANTLRDAKSLGYHGVCSINSHLITNVITQQWFQFDVFDEGPVADFEYCGRRPFANIRAGTHITSVCRFFDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6F7</accession>
    <name>A0A9D4T6F7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6F7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13512" checksum="767F5F5193D7C8C7" modified="2023-05-03" version="1">MACAKRYQGALPPVPLREDRARDRARGRAKRRHRVQAGTLRVWTRARMSHATSTHEPRASTVERVPWAQSPGINGRGVDLRDITRADQHRATASTRSTHDAVNSATSSAPTANCTPLLDYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6T7</accession>
    <name>A0A9D4T6T7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6T7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20299" checksum="21EF1CA2CFF42A0A" modified="2023-05-03" version="1">MKVSTCSSKPSIFSEVDDTSPLPFRTFSLLTFKIGVVGAWHSRRTLAQRRTRANSERQRDEIVVIRQSSLSLTVTVLICSAVTVRTISSESCSDENSFVVICAAFRRYAGSQNEDIFECGAHHANMSEVLTRMLTVARLDEDAGRRLEEVAGEAAGFDTVTVGSLFLLDMAACHTPPTGYLWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6U6</accession>
    <name>A0A9D4T6U6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6U6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056654"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="425" mass="46415" checksum="A40002D25E8C434E" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGPQDEGYTDWLATHECQRNIECNSGRMEVEAALTMFQRSWAKHGLRYTTVLSDGDSRTFHALSEAKVYGFIQIDKKDCINHVHKRMGAALRNLVDKKKAQGESLGGRGKLTQEKIKKIANYYGYALRSNINDVPAMKRAVEATLLHMTSTDDAPKHSKCPEGASSWCKYNRALANGESPPSHKNALPACVGAALEPVFARLSDESLLARCCEGKTQNASESLHSVIWTQTSKNGNASLESVKRAAAEAVAIYNQGRRATNESIAASLGYIAGDCLVRRSLEKDSLRLRKANATHLKSTNTKKTLARRHKTGATEDYSPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7C6</accession>
    <name>A0A9D4T7C6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_008896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7C6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044479"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7976138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="144" mass="16483" checksum="AA2C81DFD8751487" modified="2023-05-03" version="1">MADIDIDNLLERLLAVRGGKPGKNVDLSEGELHSLARKGREVLLSQPMLLELEAPLQICGDTHGQYYDVLRLFEYGGFPPESNYLFLGDYVDRGRHSLEVISLMLCYKIKYPENFFILRGNHECASINRVYGFYDECAFAIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7H9</accession>
    <name>A0A9D4T7H9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7H9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027362"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028059"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="633" mass="71052" checksum="DAEBBEA57C4A2A45" modified="2023-05-03" version="1">MPERKSFFARVTSSNGDRSALCNSTKTAGVWMDSNFFNFGRRESVVAELSRHMDVDGFGELGDHESGSCPIRGMASPPVQSTEISILTPDYMALLHSMCTITKPSLNDVTAIFKEFRRSLDARKPKPSPKPSKSSPSSSGTSEKRGRKSATRASAASDDAGGDDCGIAHTSVGFERSCTWEPDEKRCWIMSDMELWNRILAHDCIELRQFTWCELALMGYHWPEKKTGDQDILRASLLIHVLLRQHRCVTYIYLDLDYTALEKHVLWHALKTGAMGVKRLEYRQNFMDMICAANKTLKALVLNMTTKHSQEDVSSLFDMVSRINAFSRLLLHWVYPRASDFPKSALMASTPSVSMILDDYEAEDAAGALDTIASSCNLDMATIQCSANVKKAVIQRLADTLASTKHLVLSMAFFPDADVFNVFRALESNRTIFIMVFNAITFGERNAKALGRLVERNRTFNSLILDLNHSEPCVDRMVQFRNICRELKEALRRNRFIAHININLGNSDLSNDPAIKEAIRRNSALINQAIRFVNGSMDKTDALAFETLQHCRSVSIRMHSHGGISLESALQKVAEARERLALNYFVLAGVVKAKLVCQMTRKEEKKMTLLDKIGRVMQARICSYLSLTDVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7R5</accession>
    <name>A0A9D4T7R5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7R5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36228" checksum="D7D8AB63C1B02CA4" modified="2023-05-03" version="1">MDDPQERSASVTWPRYFVLIIVDVLAAYQLVLLAIDVFLGTTIRLSFAHLQLLTGYLASALSGHIFMSSIGKLQHYRLQCHADTKTTRKGQFRMPSLSRALLVSSFVAFAILDVCAQSFKPFKQLADLACFYIAALLKLAVMLNYLRLVEDAQAVIRRLGTVTAQEVREFGAALLDVFKMVHSLEAAFSLLVLVWYAELMLAIVASVHIGLSFVEKSRSFWLHGVRLPRNLYLLSVYALLSHRLCSVHGEARKMATTLGPGLSSRTDPRRGAVCGAVKILRRCASLGEAFTLTALDSFDLDDRFYLNTLGSVIMYGVILQQLTTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8M3</accession>
    <name>A0A9D4T8M3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8M3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13392" checksum="2E77AD4CB17F2A57" modified="2023-05-03" version="1">MRHLLGDPSLSARTTRYASTVVCLEDCCLCHTPAAPKLLLSDFYKQSCTREPCAALHTMYPERFPSPDCPLCGGYADFEHVLWDCASAGPPFTQEEMKKLIKAQDQTSQILEGPREGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8P5</accession>
    <name>A0A9D4T8P5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_004194</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8P5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052140"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7982352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="462" mass="52315" checksum="7BF9362299BD025F" modified="2023-05-03" version="1">MLDEKDDTQRWRRPAAGEAEMLCLQALLSHTALPEHRRFLVEELGVLPLLQRVLQEHAHDMALHSLVAQMVANLALDSSLHDHIFRAGWVGILARWLRSSEVLLSFPAGRALANMDTDSLLPTKYEDGIYLLHPQYRIREPSVSADIIFVHGLLGSVFKTWRQHDSQDLGKLTNLEGLLEPTVSAVRSSACKITVDHTSPRALAMHQRYTKCWPKSWLAEDMPYTRILALDYDTYLSQWSPNCPLEPKKRTLVSRATDMLTKLHEAGVGERPIIWITHSMGGLLVKEMLAIASESPKYEGIARNTSGVVFYAVPHRGADLGDFTASFKLLLLPSVEVQELEKDSPHLLEIHDKFEKLVKKFGIPCLSFGEKVKTVLGFRMSKVLVPVESADPGFGDFFVVDTSHLEICKPHRWSSFSYQLLLDFLDHAFSSMSQDAYWAAHNPTLSRLRQLELYFETGVFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAD6</accession>
    <name>A0A9D4TAD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_014039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAD6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7983736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="459" mass="50548" checksum="4DA4487A5EBC2239" modified="2023-05-03" version="1">MAAALAPQDLTEDSICPNVTQNIFVVCTPSERNARAYTTVQQLRLRDTLYRVAVYPAPPDDTCKGVIRGIDLDLNDNQLRELIVTKRNPSALEVKRIKNTPAVTILFQGMQVPNYVYCGASVIRCTLFRRHTEVCYNCGSLGHRADVCPNPNTTWCRTCGLKTPPENHQCKPHCTLCGGPHPTADKDCKRKFQVPYIVRQRRRRRRQRGRSRSRGPSGASSRNSSATSSTSAASRRSRSVTPAAMPAGLTWADRVQGKQQSQRSPPPTKQVTRPSLPEHESEIVTTLRQELAGLRATIQQLTTQLNDARQQIQTLTAPKPVPSPSVDVSKPKRRAPSLSETVSGDSDTSQDTLNEILRLTRENNEKSPRSLALLGDNLGKHNMPVANSLWVGFAEVLLLLRQPNIAEIAMAVAISITLESARASCRNTVAGLAASRKKDTKSVLDRDLLSTLPGQLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAL7</accession>
    <name>A0A9D4TAL7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAL7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050068"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039203995" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="80" mass="8606" checksum="1EA4F8D1456BF456" modified="2023-05-03" version="1">MTGWRATTLLALLLLRQLSALLVSALASPWPAAGTQLPVPFTETAATEGCHCWAQGTECRCFGDSVHEVPVRLADQVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBZ8</accession>
    <name>A0A9D4TBZ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="664" mass="73130" checksum="BCD7BBBB8C12A973" modified="2023-05-03" version="1">MHRRAETTTTRNALRTEEFVVLRGDAIEEAAKTSKRRPEITSEPATEPKRHRHGSCRLKSTVRRLPKRHRAKATSGDGQGVTTASGTFTSVVPLPVILCVMDTRFAHLNPDRRSPAMRRGSGSEDEGVQGNPQVVVAPESQRNEHFGELTRKRRLEERDPCSELRRYSKVLTGVLPKFPTEAEAPVWFESVESALEAYEVRGEFWGRLVFPLVAERVPFLSTRLSPIEHKDYQVIKQTVLAELWLSAGEYLKRFSGSGKRANEGWRPFASRLENYLHFYLDARGVSTFEGLVKLLVADQLKKNLSEEAVRYVTLQEGRKTFEEAQGANSAARQTQQKSAESQSASSARPDNETTKARNAGKSLGVGNSEVGGAQLELEHEPLHAVVVQQQDEGNTRAQSVERHATEEIDDTQLTPDSRPLRTLKVQKLDVESSVLEAQGEIATMEGVITQAVVRSADGEGPRGSRASPGETQAASKQETSALQITGAGQDGIVERHGERSCFVRVPTGPRNLVRGSKLRPRCPRSELKGVLFEEGDAASDVACAPMATTAQVGKRKRSQASEVFGRHGGPLGGEPNVISGRQREDVVRAGFTRKSKYCKGETTGRVDQLLDWDPRVQSLALRRINDRGLWPPPTVTPDTDTLSRVPNECWEVGSGASGVETPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC47</accession>
    <name>A0A9D4TC47_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040329"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13814" checksum="3E9048F27D86D0C5" modified="2023-05-03" version="1">MRAVRRRQCQKIPSVVETVTAGDKGYYTADGCFFLCGRFKELIKCMDQQVSPAELEELLASDPEVLHVVVAGVPHSQYGEAARAFVVHQRRLTDPLQQQKEAERLKEVVAGKAFGTFMFKNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDJ2</accession>
    <name>A0A9D4TDJ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenocysteine lyase</fullName>
            <ecNumber evidence="8">4.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_024993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010000451">
        <property type="protein sequence ID" value="KAH7986401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041560"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043693"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054835"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000083">
        <property type="entry name" value="Selenocysteine lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF62">
        <property type="entry name" value="SELENOCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7986401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="773" mass="85051" checksum="C69032031F7583AC" modified="2023-05-03" version="1">MCQMVQRLRGIEVLEGLLLYNGQQEDGSGDFISVGLTNGYVEFRFELGSGVGYLRSHQPVQMDTWPLFRSAEKRRTSEVTGTSQGRMMGLDLTQPLFVGSVPSFDKISRDNGYNIGFVEVSIVEPAFDDDAFAAYPTPKSSQNSLKVHMKIKPNNLDDCLLVYCAQYLTRKETLPPLESAWKCPAIIRHPERLRANEWITLSASRRAQNGELVVNDGHREVGRSPGHTQGVNLNTPMYVGGVDKTKVTVHPDAGVSHGFEGCVAHIEVNDVSVDLIGAVVDAANVDDCGGRAPCEKNPCQNHGICRERGPKADDFECFCKAGYSGRTCENQDDFCQKINPCHNNAECVGLANSYSYEMGGGPAEIVSEERVDDGQLHAVELRRTGKRGTLKIDNKEVHGESLGLLVMLNTKGDIFIVHAHLHLGANRNGRAHDMDRFAGSPEDTQHRHIAHQSTVVGLPSSLGKQHGVFKHHFIDILRGPINNWVAGKMENTCLKLLFVYLDYNATAPVEEEVQKSIIYALQVAWGNPTSNHDGGTEARRIIDEARMSVANMIGASPPEIVFTSGGTESNNMIIHSLVRHFRKTRSSFAPLSNCKIPHVITSNIEHNSILLTLKDLCEDEHIDLTVVPVSKVTGTVSAEEVITAIRPNTCFVTIMLANNETGIIQPVNTIGTLLKDVNQQRKKHSLPEVLFHTDAAQALGKVAVNVDDLKVDYLTIAGHKFYGPRTGALYFRDSKPLYPLLFGAGQERGLRPGDSLFAVVEPSPDKMQYEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDT5</accession>
    <name>A0A9D4TDT5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000320">
        <property type="protein sequence ID" value="KAH7986686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045578"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="27192" checksum="5FEA99EF45BFBCBF" modified="2023-05-03" version="1">MAPPSLGLPKPGCGGGAPPVAPRKLKAGFLRGSSTAEEITAEADIDAAAADGAAAVTSLRQLWEAAGDASLVPSGLDYLDIALANQDLVATEELTTDELAASVSEKGTAADSSSSDGEGDDIGAPQPGTAGAALAAVDTLRMYLCSEPGSCDLMDNVEHRVLKRALAKRPSQAKGRQPMRQGPLRVQHHPLRHSNLLSSICSFWAMPPGRSGARRGGLRQQPLPDGLSKKDLEAFRRLYQDHCDASALSCNAIPWAYLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPY8</accession>
    <name>A0A9D4YPY8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPY8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049070"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="136" mass="14984" checksum="84A7DDA9DB695F0C" modified="2023-05-03" version="1">MVMSCLRSVIREEAQELRLEYFRQTGITAGAGDMSSSGHHGSSSKAPKAKNDMAAGCRRRCRFPRSKEMDDNADLRLVEDALASYADQWADLEGVTDCFTAAVFKCRCSCSETPQRPGHIVRHLGALNDLLISAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQ57</accession>
    <name>A0A9D4YQ57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQ57"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034328"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="13255" checksum="56168F14F7446EF3" modified="2023-05-03" version="1">MLSANRQRTWLARRRRANFDEQNPNESRPRCSTRRTQTGRRRLYDSATAASMQALRHMSARKNGVMKNGKRRPNGAEHWPMRVDEAECGSLPMTETRDRKTRCGVCTSQHSHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQS2</accession>
    <name>A0A9D4YQS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQS2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26134" checksum="D314C5CE6934ADB0" modified="2023-05-03" version="1">MAPLTCGKIGHRADVCPTPETKICFACGAPNPAADHAARCKPRCKLCNGAHATGAEGCTNKYKVPFVVTQRRWERRNAASAFSSQDFPQLPPQQQQQQNEAHLTKKKRSRSRKRDKSRGRSASRGRSTDGKRSENMHVAQANDNTVQSLRNENDQLKRCIAEQRAQMQEMNAKLNQLINAQQQQATPTLPPSPPQIQSRPPTRSLEKLPTELPGMARPRVQIKWVLHSHTETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P9G8</accession>
    <name>A0A9D4P9G8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P9G8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="533" mass="58589" checksum="E02858B5B40CC470" modified="2023-05-03" version="1">MPPLPTEDIKIVIRPKGALHITKIGSPVVTTAILQAAELTEEESLEDTICPNMQQNIVVVSTPDPDHADRYARIRSIQVNGVTHEVNAYETAAEHTTKGVIRGIPLTETPQQIHNNIVTARNPTALAAKRIASTTTVIIAFDGPDVPYQVRYGPTLLPCSLYRKQIDICYQCGRFGHRMDVCPYPNNKICRGCGARNPPADHSCDPKCCLCGGPHLTADKSCTARYKTPYVIRKRIGERRATSQAIDQAAGPSTLDTKARSRSRNQDKGRRSRSRTSSRSRKQRSRSRSASALGSKSTYNTKVSFAEKLKGTSPKGRNTNNTQAAPPLPLPDNPEIAQLKRENAILRDLLTKLTQEVRALKETQTLTPTPTAQNAPAPSQEAPLPPAPKRRALQDGATGQVRSEVKDMLISLQTTMSTFQQALDSIQHALTGIVQRPCCPRLRPFWDADGDIPYFPSWPTLIKAPSFGSGTAEAFTRNNRSSINTYVNIPAALMLFYSKKPTTPLPHSPVIKHFIQLTLFAGFYPSTASHPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR3</accession>
    <name>A0A9D4PDR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051639"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9551" checksum="0CAD8C592769F9A1" modified="2023-05-03" version="1">MLLVTPPPFPLENIRSRIGLFRGPSDRLADPADVDDLVKRIGQVVALNYYVPQQTFQHLDFVLGSYATDIVHNTMIQFVSNYSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFC5</accession>
    <name>A0A9D4PFC5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFC5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="36506" checksum="F0CD1C2CBF38258F" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQALMHDILLDALPAELRHMSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPTSTRAVPPGPQPSHDHDLPSPATTPPTSRQATSASIPAPDHPPDDVQEVPAATGHSTESSVFSTASAHGPSDVPAICTSSPTSTAHDTSDTSGSTTATSPHALEPAIDTDIVTPAVRPPIAEASTAMSNKPAFSTSTLCASCQQELPSDVQAYNQLRPNVRDAATMTENPEDHPPCLPQVDQTAYALPATQAYNPPAAPHTRSPSPTKLHSATTAAPSTSLSSTAHHTGISRAPSICSARLAARLHSTRQTMEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHR4</accession>
    <name>A0A9D4PHR4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHR4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049738"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="927" mass="101001" checksum="EB3E8F9D78A0A9AC" modified="2023-05-03" version="1">MDPRLMKKGGSEREHEVGTPGTPFTKSLRGASDRCSVDCSPRPTPTLEENSTNRSQFVDALEQPDTSAKEAAVSEEPRLLSTHAPRKRYSMDAKEDAPPAIEGIAEQTQLEPCESLTKRAATDKSVARDMVVPTKHASQSPLSAVINSGVTGKAIPGANDVAEAPPVDHRETMWKRASIDKSVSRDEVIPTRPAPHSPIRTEPSPSANSKDAAVVDITEELRKDPREPLRKRASIDRSISSGVLVPTTPPAHSPLKNLSGKDILDVVEGVLQDIVDTAEMAIVDPREPLRKRGSIDRSMSLGMVVPTRPASLTRVQTLPVDGATIDSDDKSAADPREPMIGRASTDMCVSEGHVIPTSPSVRSLHSFTDSGGQPSAFARKAYRRRPETSAMSRPLVGAALAVMALAVVVLSILVVRRVQSPLRALSDDVCDTDDCVQHARDILATMDEYADPCVDLYAHVCGRGPQWTSKRTATMAHAYSRDVMPTFGDQRALQDFEPIAPAVIVASNAAKRCLDTSRGSEDETFVTFMRNRKLSWPHPAAASGHKAVPSDVLDVLLDLAVNWRVALWFDVTVSSWTRDGDAVVIVGEHGDVPTLRMEQLAEFDDASYDDVARNLCAFLSGGRVALDGATLEELRRDETAFRKVLLSGDEEDEPYDDLVLLSDVTEVFGKAASSMEWTSLLSKYLNSVINVSADTKLLIMNERRFASIGGLVGSIPVSRLLNVVGWTFAYAYAWIVNTDFDFLSAGTAVDLARKRVQYRWHSGSVLYLYALNELRLSLSALFPPSYLRGGSGAMTYAGLDFNLARQALRSVDLRGRALDGAGQNISWLDVAKSVAERRSITDLFALDLALAAMQQASEKDREKRPLRLKYLEGLTATQTFYVSYCSHYCGEPSGRRQCNVAMNGSDFGASFSCPHPKQPTSQACVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI30</accession>
    <name>A0A9D4PI30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_009636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040359"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046325"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049584"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7943632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="865" mass="92899" checksum="6E6CDF07FF105536" modified="2023-05-03" version="1">MSSRKKLWLNLGRTSNLSLGNLAMGLIVSITGVALLDLAELYGSRLASISYLLTTRGVGHLLGSLLGGKLFDTYNTQLITILAMAVTCAAVVLTPLGGYLALAHIAIFLCGLGIASFITGASVWIIRMWPANTSPPLQVFHLAFGIGGILGPFVARPFLSAGTGENSTALNVTETADQSHIHTSLYPVDLMEMLHPATAGKDMGTSHVYCAFGIAGGLYLAVTISLVLLYFVDNRDFKAGAVPATNDTSLADNRPSVPVRYTRTVLAFMCIYSTFNAAHGNTTSEMLASFAVKSDLRFSKSTASGVESTFFLCVAASRLCAALVTIKVPVFWILVLAHVILLPTAAVLAVFGSRSAAVFWAGAALTGIGGKLHDTYNTQLVSIIALAVTSVTVTMIPLSGILPLAHGTMFLCGLSVAAFLTGMEVAFENTTSQMVASYAVKSRLHFSKSLAARLESAYYFSFAASRLTASLVTIKLPIFWVLVAAQVILIPTVVTLAILGSSSSTVLCICTALLGVGQGPVYAAIIAWTSGNIVLNNKMMALVAVTDGIGSMTAPVVVGQFLAAAIDRRPVYNIAHMVNSIAKLDEAMADGANSVEADVSFADNGTATRLFHGVPCDCFRACDIEEDVPRFLQYVRKTTSGHSVKSSDVVLTEISLQRIEGNGKYGIRSVQKLFYNTINLPTWQAMNVLLSVPSVSDKEVLRGAVHTVSRLSPIMLDKIGFDISNNDKLDNIRSLYADLGIQGHRWQGDGISNCLSYLRPAARIQDIIDNRETEEVGRYVEKAYQWTVDLPKQIRRSLRRGVDGIITNKPQRLARIMREGEFNTTLRPANVADSPWTRFGGLSPLPRLPSDDMDILGDDDFPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIC9</accession>
    <name>A0A9D4PIC9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048541"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="247" mass="26989" checksum="4628FFDF6B7E717F" modified="2023-05-03" version="1">MQSEERRNLYATGGGPWTCRPMSPSLALVGAAASHMATRLPNPYDSDGAHTSQPVLSLPPARILESMVTGSEDTMEELLDMSFEPILPATEGAASAVLHAVPPSMTDPPASSTECAHSVPAEGSNVPRTAPTAAPRGSGNALAGADAPLPSRSARSRTAAVERVLAPEVAARMEAIKNDERRKAELHAVELRLRRQQLSQQRQLHSMRMKQEQELYKIQVRLLEQQLEQQKSRFEMECQKQQQHADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIS8</accession>
    <name>A0A9D4PIS8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035337"/>
    <dbReference type="OMA" id="YQPREYQ"/>
    <dbReference type="OrthoDB" id="6422329at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="332"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="612"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7943333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="961" mass="107694" checksum="9053297BE5C438F1" modified="2023-05-03" version="1">MPGESGRTTGQGRGRGKKSAPGVASPPAGAACNGFVQALKQRLESDPPTVNGHSNGFVSNGHRTTTGGTAAGRPPGSMSPTSPPATTPPRTGTELALTAGGSPNDEMRIREVALTLPSHFPRRPAHGTLGRLIQLMANHFSIEIPDGSIYHYDVEITSTEEARVPEQKRYRCLSTKINRTVIELLVKKYRGELSDCIPAFDGRKNLYTRRQLNFRERIFSVDLEENQRIQRFTVKIQYAATVNLDALNAVYKKRTHNVPQEVIQAIDIVVRHGPSIKLTPVGRSFFKPPYETYALGGGREVWFGYYTSVRPAQWKPMLNVDVSATAFYEPLPLVNFMCKIFGGRRVMTPSEFRPLSESQHARLNKELKGLRIKVTHLPYPRKYKVVRVTRSSASAISFDTDEGASVTVSQYFGQRYAPLQYPHLPCVQSGRPEHPVYIPFEVCELVEGQHCRKKLDENQTAEMIKRTAKPPAQRFQEICQSVRDLVNSSEDYLREFGIKISTDLTQLKGRVLDPPTLVFEHSSVIKPRDGTWDLRGQHFYNPATMDRWTVVSMSRSAPRDSVDNFVKMLVRIGKELGMRIHQPLDISAADPNRRPIRSILCEQLKNHGGLQMVVLVIAKTTNYAEIKQVAETELGLRTQCVLDNNVVRKCNAPLVQNLLQKINAKMGGTNNSLLSQEKPSLFRTPVIVIGADVSHPSPGDRVRPSIAACVGSLDATPSKFHSSIRIQMEQDKGNVDIIRELKEMVKELLRAFYRATRQKPQRIVFYRDGVSESQFLEVRNREVSAIRQACKEMSPNEMYEPPLTFIVVQKRHHTRFMPANERDGVGKCRNVPPGTTVDSVVTHPLDFDFFLCSHFGIQGTSRPAHYYVVWDDSNFTADELQKLSYYLCHTYARCARSVSIPAPVYYAHLAAYRAKNHIVSKVDVPSSGSDSSGGSGDNVAPIQYAEAVRVLDELRTSMYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIZ5</accession>
    <name>A0A9D4PIZ5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIZ5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="147" mass="15845" checksum="EFC078188D8AF219" modified="2023-05-03" version="1">MKKAEVDKPAADSKPAEEANGDAAPPAKKAKTEPAWTHAERENKCAGGRRVSSLEAGANEVEDLLYELSHKGSSDQTVAAGVHSRRRGAPRLLPLHGSLHGRPLPSQRAVPRRLRPLSAVKKERELEEEEEAASAEEASTTAAKEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJT6</accession>
    <name>A0A9D4PJT6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJT6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10003" checksum="1675A15038A10BC7" modified="2023-05-03" version="1">MIYAAANPAESGDATIACPVIAAELLPSCFRPENIRGRFAEGDAPSQLRRITSLTPRHLNVEAALPFEIANAFDDLLAGAPSAIAYEVLNHTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKB4</accession>
    <name>A0A9D4PKB4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047865"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="575" mass="64908" checksum="0509A71FCD84DF14" modified="2023-05-03" version="1">MCVRLTTDQGIDNLVHQIKKFETPLEVVELDLTNCIHLDTDEVIPIIEKCQFTDSLRCLSCSIRPGALVTLILGYMRHLTRLELTLVCETAEEVGEYPDKHEMANRYILPDLRSIYVEMAYDASFLLFDKILRESLNLEDLHVHFLRGSFENALVACKVLCEQAIRLEKFTFTSEQPPYCQQLSSPLELFNCMSVCANVEYRKLSGFMSFFALHDLAEDCCKMRCMPNQTTLAAVHTEGKTLAAETMRAAFRGHNWSWINRVCFVLLPEDPSSLVYPQAGLAYRDSLLFFFASTFRYILELNISSFHFAPDLDVKELLQDATLAKLRYLRSLSATPCGLRRLSALRLLAQHCQDFTELDVRYEKKGGVVRCAGCEADVPLDPDAPTRVPGGSVGFRNRLVRLTVCGVRFPVGLHFIECSGPTTMVRLSGCSDLSNQHCTHLAKLLSERSAPICLVLRHGCLQIHDASMVANLSSVQSLLYLYLLSTVAYPDEVAESCFLALRTTLNRLRYLHFHYLSLNGVDRSLTWLRSEDDPQDGGELLRNAPCFQCCSTATFIGLAKPMNREFVPHAQAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKD6</accession>
    <name>A0A9D4PKD6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKD6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="191" mass="21914" checksum="8180A361D99E2C48" modified="2023-05-03" version="1">MCAHCPALEYQNAEDAVENIPRRHWENSRHVPHRRKIKISRPSIKIEVAKKKPEQEQKCPHPCAEEPQSQSGDISFYASNKQQARLEQRPTKERGLEHRRSRANRQSSDYSARIQCQTRGKDQEPVNILDSRWPFQIQFEIKDTATGQTSRQSGAGTGRAGKIVTVTVGFGQRTDQATEKQFQFDLYPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKK0</accession>
    <name>A0A9D4PKK0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKK0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037973"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23079" checksum="15AF51B92030D998" modified="2023-05-03" version="1">MAARRSGRRHATAVRRARFKARPGEGGGEGSAFIYPTGRAARVFLKASPPLRTRRQIEGRRAITARRITGLVRVWVAVVFSAAAPGGARHGECSPLPDALSARRCCLGGRAPPAVVRSRELPGVAAGAPPRASRSAEGAADAKDADLERRRRLVVVVQRRQRELRWAAVMFGVGEPPLVCQEAVFTRDRGPRAFLHPFSPYGRAVLRVTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL30</accession>
    <name>A0A9D4PL30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL30"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="10979" checksum="DBA267CEEE841315" modified="2023-05-03" version="1">MPLTCLTKLANHHDASLYEDSPELTGGYSCDCASAATTPPRGCIAFPVAAGPTVSTAGTRKRWSTYSYVDLPSMQTGPPCWTFTADSAYQGAPPRSSSSPSAAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLA9</accession>
    <name>A0A9D4PLA9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLA9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038296"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22674">
        <property type="entry name" value="FHA_PPP1R8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="325" mass="36365" checksum="AEC629F51E439256" modified="2023-05-03" version="1">MANHYDVPSWAGKPPVGLHLDVLKGEKLIQKLMIDEKKCYLFGRNPDLNDFVIDHQSCSRVHAALVYHKHLQRAFLVDLGSTHGTFIGTIRLEQHKPTQLPVDSKISFEGLTYETRATILFHCSCLSHFVSDVREFQYELHAPSLQNLTEYNTAHNRRITMLGIPDEELKPPNRKQKNLSVKFNEEEDVINPEDVDPSIGRFRNLVHTAVIPKKKAKMDTGDPLSTLLPDSDKSSHMHPFSKPESTHVSHLSTIFSPMLSAKLGLHLPNPAPEIEPAGAPLENPAAPVVTVHPAVVDANLPPEPKKKKYAKEAWPGKKPVPSLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLM0</accession>
    <name>A0A9D4PLM0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLM0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7947332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="15458" checksum="C0684E7C04B0C8AD" modified="2023-05-03" version="1">MVYCAVVGCKSRTFTKAEKEKARQNNQELSNFRFFKIPKVRVHECGKTKQLSERRQREWIARLNRKGVSEDPQKYKVCCRHFSSDAVCQTDMSKEEIKELENSIVRLQLQLGALADKFRHQNSTEKSLGNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLS3</accession>
    <name>A0A9D4PLS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLS3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="24125" checksum="3D08D89042518159" modified="2023-05-03" version="1">MTREVAGTSRCYFPQDVATPQHGDFEDPSVNAAEFAESRPIHRSSTTYYQRSLYPQRFRTERPYRRPTNGYVERRTYTNDHVNVPGHVEGQRRLRPAPVCYNCGVTGHISRYCAGALERVSNHVALPERVAQISSVREADASAMIREALRSIQGMHDFMRLAGVVKDRVQCGSGMAESRSQLDSLDDKCWMRVRRYLRLDDVRDSAPQPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLZ6</accession>
    <name>A0A9D4PLZ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NOPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031524"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012975">
        <property type="entry name" value="NOPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOPS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="113" mass="13473" checksum="E4BB689ECD6DEB95" modified="2023-05-03" version="1">MAASTPRPVVVEPLEQRDEDDGLPEMNFQPNNKQFQKEREAGPRLAEVGSFEYEFAMRWKKLYEDERARHEQLEQDILSCRRSLEDQMEALLYEHEANMLRESLENFQKVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMQ2</accession>
    <name>A0A9D4PMQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041539"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7946898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="263" mass="28267" checksum="C1A8C8E16114CCB4" modified="2023-05-03" version="1">MASGDEAETRPMRTHVRDFQCGLGSWRPKWLQTFASARCLFFFLNVLAMCQSAYKAYTMGALSTLERRFSLSTKSIAVILVAESISPIFLDIPLGYVASWISRPKLLSLGMMVVGCSSLAVALPYVIFGPATHLLADEGERRQPMDFASLEFCGGGGGGMAVKMSPDCTTQATESYLPFIILFVASFLNGFGQSVLHVAGSSYIDDSVKKKSSPLYFGASFSLRSIGPALGFLGASVSLSLYEDPFPLRDLDAAGCAVVDVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMW6</accession>
    <name>A0A9D4PMW6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMW6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="8577" checksum="3DF5FE90E697CF17" modified="2023-05-03" version="1">MAEAEFSAGCADAPGDVKGPGLVGKAGKGFSGPGVVAARWDEAVSRKSDTRGDITCKIVVAAAKPSQAARQRHPPLLSGTSTEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN91</accession>
    <name>A0A9D4PN91_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN91"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043050"/>
    <dbReference type="OMA" id="NVSHTNM"/>
    <dbReference type="OrthoDB" id="6492805at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18691" checksum="0FD565AB1DA0F2FB" modified="2023-05-03" version="1">MAVPATFHYQGTRTQSPASRICGRVLGTVVGLVIGSFLLVLIGMIASMDVFMPSNGIYRNVSHTNMGVLETVISLAVKNIADRYLNSGNHDESVRTTDHNHSSSLLIRNRSLAFHEELRGQMGAQPPDVDNSSSEVTTPTAEIPVVRLTANQGFGSRNPSLKAARKFWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN99</accession>
    <name>A0A9D4PN99_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN99"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7948051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="18393" checksum="ED8BA5463F75B425" modified="2023-05-03" version="1">MSRKRGSWKKIQDEFNCRHSVTPRKKTQLKKCWENMKDKWRRTSAEDMPESFATGCENYEEPTDPWSWDDISRPLADTSTGTALAHGQAPDTSQSPSEAAAAPQTTPASAAATSTSSVAVPASKRSASRIQRQTAVSTELGARFDVIKEERDMAGGGSGTDEVEAAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPA7</accession>
    <name>A0A9D4PPA7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPA7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="21297" checksum="06095AEEEAC167A2" modified="2023-05-03" version="1">MGIVSTSKESISLPKYTGAEDDVPVDKWLRLFEAKASNVARSERDCINYICEYLEGEAFRRYLTEIFDVEDSRGGIKDSMKERFAEPITDPFRQFIHCRLKKAQRMRHYHDEKTRFGRLAELKDAHIISGLTDGVPEDMERRLAGLTLSTSQVAIAAALQAEVSVQSDVSPRSLKQQPVQREPHPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPK3</accession>
    <name>A0A9D4PPK3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_003564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPK3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039457"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7950966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="73" mass="7824" checksum="03756BD67953A5F8" modified="2023-05-03" version="1">MDGTPKFGGVDYAVLAAMLSVSSGIGVYFAWRDRRDQSNQSFLMGNRQLGFVPVSLSMMASLQSATTVLGYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPW7</accession>
    <name>A0A9D4PPW7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_001943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPW7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047584"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7950817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="67" mass="8101" checksum="FD2ED51ADDAED93E" modified="2023-05-03" version="1">MPETAIQYSDKYYDNKYEYRHVILPPEMAQSVPKNHLMTETEWRNLGVQQSLGWEHYMLHLPGMEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR15</accession>
    <name>A0A9D4PR15_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_008924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029578"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7951420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="24751" checksum="8592B43AE8B521C8" modified="2023-05-03" version="1">MSAVPVPTSPKREAFVTPNASSLTLRPSAWASGPSGCPVSHLAVEYRPRDGTGPWTVASRALQPREGPMTLHHLRPDTWYNLRVTVHTEAGTTSSEYAIRTLSASATLAGTVLPELMVVNGGGGVDSDLPLLVPITTSLSLVLAAATLVLAYVCCRRRSEPTFAKDHEGLPVGRGGRSASNDELAELALMKQYSIDKVLPTLTSASGRQGSSCLASPGRHSVVAPAATPTQALYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSD4</accession>
    <name>A0A9D4PSD4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSD4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24280" checksum="FB455DBA0B12A2A1" modified="2023-05-03" version="1">MTAEYPEHAPYSVEYLKTLFTNKRRTYRKEKKKVSDTKSGQALAEGYSGKWKYFHAMKFLENITQRGPRFVSGADGAQGTVDELGDLSNANDVPDSVSNVPLESTQLPLNEEEEDQSSATEDSKGTMEDAAIVASTNAGKPCRIRRPQDTCETSDEMFAQLQALLENIAKGIQPEAPDDPATHFGRYVASLMKKMSLSRQLMCQEEIIAVLQEYVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU26</accession>
    <name>A0A9D4PU26_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_003840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037597"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="951"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="829"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1325"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7955768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1387" mass="150003" checksum="B985DEE7AA1F0BDD" modified="2023-05-03" version="1">MVRLFLVEVTIFQECQPEFLHDLVLKMRAYIFTPGDLICRKGEVAREMFIIADGILEVISETGKVLTQMKAGDFFGEIGILNLDGFNRRTADVRSVGYSELFSLSREDVLSAMKDYPEAEEILQAMGRKRLMEARLAASVKKADDIITRSSGGGGTAAGAGAGAGDGSASPQGSVHSRGPRSMDAMRRLRKDVKNIRQLLRSRTNTTTQKPPDIQLEMDPAMSSTDDHQEDSEAATPSTPVTKSLQKLLRRFQSRQDSQGGQALKGLVTSMSCIKGEEELADFARRPSALKSMGPSMGSPATQESSGSSPVQPIGAGLPLLTRIKMLREAEKAAKAAASSDASSKPLLVSPGGVHSRRESYAQQDRVASRLEPTAHSSLLERRRLSRLQASMSTASAEVTAAGRSPSAAEKATSRKSVADVLQRLKPGGGGDSTSNKQQQTPTVTLQVHPPPPSDPAAEAVANQNIPLLKRVLLLKAMEDKKEKEHKPQPTTAPAATSTSAPEAAAAVDKPSASSSSVVSTKLSPPRPDTLSLSPQKESAPAAMSSADQGSARTQPTTTSSELGSDSGHPRILSPKFELEDEVFRSPSPVSEPCERKPRLTHDGGGGGGGGGGDFRGGGLVSSGPPGQPVAYANSAILVPQGSVIGMSQRGALDTLEEAQHSSAESGSLDVQREPQQHQLSQPQEHQQQADAMARLAPPVAPGTTNYSQQSFRSRLWSRNTMEGHAARRSLLQRMEAVELESTDAGSHQVPPSRRPLSPRTAARAQGNGGDHPRGRIRKVIIERPSPENGLEQCLVSELLTQEDGIEQYVAAAMKHIKIAFKTYLHETQDELRNKISLLEDDLKRKDAVICDLQRKLLIKEQELSHLEREMSYLEEVSSLSDTSLTWSDEEDLVLTVAAARLKPEDLWKLEFPASQDQSKATSIDFSLSTSKMSSGGSCTTLPDLAVPQPYSPSVRSGSATSPLLTYPRPPTSTNSDDWEVQMLVEEFEKKVQKEEQSGSRRHSSCEPLSWSRALSRNLTYVAAEPHHKRHATSTSSPFSSQEEGRRRRLRRKHSLRDDRLLRCLAGRQATATDARPKLTRFASLDMPRYHRQQQKQHLLQNHYDDEPGDTRGFPESSSSDHLRSSSSSRGAALKRRAFWQSRQRHNTFFAGQAAPSAVLGNDKQRLLGAWRSLDEECEPPPEEDHRRLQETSFSNECLWQPSPARSQPTAMLKQQASTTSSVSSSSSFSSHIAGWPSTPCLPTIKEDTGAGGAGGSGRHDLTKALKLSSSGSRSYSENCLADADVGAPSQLSLTRRSSSSGAGRSSSSNASMETTIGEPASSPQQRRQQQQQQQQQCISTSTRSTVAMTETIARSTGGLTTVSAVQGKVDSVAISIPDTEPIWSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVN1</accession>
    <name>A0A9D4PVN1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044844"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14054" checksum="135A3E8448066FB5" modified="2023-05-03" version="1">MGSDSTDGAFPVDTAVPDSVEPSTSAVDMAELPLAAPGALLFYVEYGLRAREERSCTDGSKSWFPPAMKKLEVRPVAEMGLSSSAMKKWRIDTATSQLVHRSLDRDQFLGVLIAAEYRLAERALMCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVS3</accession>
    <name>A0A9D4PVS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic cation/carnitine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_005778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046704"/>
    <dbReference type="OMA" id="CYTGEVF"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7956042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54692" checksum="C9AD420DBAE787D6" modified="2023-05-03" version="1">MGPLSALQDGVYDLLDHGPYQRRFLCCGILCVTVALMQELALRLIGQSVDHWCRPPGKYGNLSTDQWRNQSIPVEADGSFSACTMYDPPEQDEKFANRTVISCDMWSYASDHVGSIVSQFDLVCDRRFLYDFSTMLPVIGYALMSPVVGIASDRFGRRPVTLLLAITVLISSICCSVPTMYAFFVTMRVLTVSSAKGAYLLTFVLVYEVTGTEWRLLFTLLHYAVASTVVPPFVDAIALMRPSWSLSHGLLAVPTLAFALWCLHLQESPGWQVATWRLHQAEANVLVAASLNRGLGVAAVKSTVDKTFQRLRKMESILEQMASPVRSGGIFETALTRRSATAAFFTRFSMCAIYYGIMIAEPLGDHIVEVAHVVLTAAAYGLIVDYMSNYGIRKTLTATLIALSCSGLSEAVLTVAEYGAAVAVVHAVTKALVLCAIGVLMCYTGEVFPTPHRSAGVSMALFFGGIGALTGMCIAKYTGEETPLVFKAFVAAMALCSVAAMQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXQ6</accession>
    <name>A0A9D4PXQ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_015057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXQ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029679"/>
    <dbReference type="OMA" id="DITYTHA"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="71"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7957074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="311" mass="34174" checksum="626D1E1E20AB6022" modified="2023-05-03" version="1">MNIITSTNIIAIITSTISSLPSAQTVNGMQRRPLAAAAAIASPSTSDESRRRATVYGLEPALCQHEQPSVQCLLRLNRDLVNIFDDPAPGVFVEPEENNITNVHAVIVGPDNTPYEGGFFHFVLKCLPDYPARPPLVRFMTTDAGRVRFSPNLYSSGLVSLSILGTFPGPSWTPDMTLETVLVSIQSLLIEQPLANEPGLGREFGTWLEKTTGYNASLRFQTLRVAICDVLEDCLLGNSSYPKVLQQAVMKHFVEQYSKYKTAASSQLGLNPSPLTGVLKGSQQYEALLERLQDLYGRILQRSSSLTLRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZA0</accession>
    <name>A0A9D4PZA0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">(3R)-3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="19">1.1.1.239</ecNumber>
            <ecNumber evidence="4">1.1.1.n12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">17-beta-hydroxysteroid dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Estradiol 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Testosterone 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HPB52_001300</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Rsan-2018</strain>
            <tissue evidence="26">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:24614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:32712"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.239"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14930"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.239" evidence="19"/>
    <dbReference type="EC" id="1.1.1.n12" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZA0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029785"/>
    <dbReference type="OrthoDB" id="6509953at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047035">
        <property type="term" value="F:testosterone dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000231">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH7961057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22077" checksum="4344C4888BD98789" modified="2023-05-03" version="1">MILVFTTPFTGTGTPHRSALLDVSDTNSVDRLFSDIKESESLPLSVAVNCAGIAKISPLVDTSDEDFDKIIQVNLRGTFLVTRAAARAMIASDVTEGVIVNVASILGKCGLYGLVAYTASKGGVVALTKSVAQELAQHGIRCNAVLPSLTQTPMIDALSDELQRLGIALTPLRRMCQPEEVSEAIVFLCSPKSSFVTGATLEVTGGFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q085</accession>
    <name>A0A9D4Q085_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q085"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044213"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18453" checksum="F8F24AA35C43D869" modified="2023-05-03" version="1">MSAILYNLPGSPVCGFVHSLAKHLGVELTLKDVGFAKKEHLSVEYLKINPFHKAPALNDAGFIIYESNAIAYYLLRKYAPESDLYPECYKERARIDQCLAAVASTVQPRQLLFFRATFWENKKPTDEEVAAFEENVVTGYQHLVTDKFATGDSSLSLTFAWLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0N7</accession>
    <name>A0A9D4Q0N7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030305"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036986"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044940"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054967"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055128"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="188"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="696"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1449" mass="162230" checksum="63C32CC83C3140FE" modified="2023-05-03" version="1">MEKDVASLRERNRNIRVLFSYGGGAHINSLLKRLRNKKDQEKMINTIDSLVKPKKFDGVNLHLEGPGPSICNREHFDRILTFIKMPCLKHWVDAGVPRYKLVPGIATYSRTFTLDDPSNNNVGAGLQPDQPLGDPGNFTKTIGYMNYVEARWFRSQGMGGVFVWSLDTDDYSGDCMGELFPLVTSVYHALEGYRPVMDNLHDEGTGIDVQVVVSEVEGRVTQPLVCFMRGEAFERVGTDNKTGSLIFRYRGTTGEKNILRDMGMLKHDTSATEVRTLVSYGGGAHLQSLLKQIRDPQKMVRFFHEVKRWLVIFGLDGINFHLEGPGPPLCKRSDIEAVNNFFEHFRRFLGWDYIITLQLPACRDLKCDLRAYKRISSHLNYVFLMTFDYKLNDLSKTKLTSGLYHYEGNQSTSIESESCLGRWINAGVPKRKIIPGIATYGRSFTLRDPARNGVSDKLDPEHPLGNGANFTRTDGYMNYVETCRRVNYYHWKREWVKYAATPYIHYKDQWVSYDDKDSVKVKAEWFLKHWLGGIFVWSLDADDYGGDCVGEIYPMVKAAWKVMASYRLKRMHRAMGRVRNMEPSHLSWLFIVVVVVIVSVHDAMALRGRRRTGNIKGGGYGGGQCRDHHNHYPDYDHGNEKWGGSGSGSHGGHGGVGGAGVPWYMGEDDSREERNGHELQKDRQDREDDRARVKQAPLVCFLRGDGLTQTGVMRFPLRTIPSDKCTHIVYSYLETDNKTGELLYRKRGVHMEKAILRRLAAMKKTRPDLKVLVSYGGGAHWNSLLNRLRSERDEAMLVKELDMVMRNMNLDGINFHLEGPGPSTCNKDDVEKFYRFIRKLRSALVHQGILLTMQLPACRDSKCDHVEKSKLARLIDYFFLMTFDYKLDDLSRTRITSGVLQYENGKRTHIDTEGCTYHWSTAALQKNQLIVGIATYGRSYTLDNQNNYGLDQSLKKSHPLGYGANFTKTAGYMSYIETCRRVVYFHWPRQWVNFAATPYIHYKDQWVSYEDKDSVKYKVEWMKKNKLGGIFVWSLEADDYAADCQQDDLPPGFPPCYSLSGDLNHSKTYELLMKEAANLVREQATQEPWRLSPPRISPVRTNRTRARQLKDAASLLRKDTMPVSRTRTRKASRTPAAPKNAPQPGKARKGEASAMTAPPTTPSSLSGKSAQQTTAAIFSPPASSQTHPESQQRSPQNPFLEPIGSSNREECCTQHDKITFAPSQQESETNSRGSPPPQTPPSWKHTAPPSCYPADPPADSSPEETRLAGSPLPSFPAAADVTRSPQKKAASSLGTAKTAAATLVPIPATTDTMESTVADEQVIPPDAAAKQATESAGKGKQPPSQHAAGGGSIPSCVMGTLAVSDEDDAFPSLPSTGAPPGTPLCAPLVPAPPRGPPQAKAKPNGPPQPPATNTAEPRPSPKRARILYSTERRARQVVRQLHTPLGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q222</accession>
    <name>A0A9D4Q222_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q222"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033959"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="42"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="363" mass="42726" checksum="384134AF54B6B0DA" modified="2023-05-03" version="1">MKTTIKKMLTAASRRQYSGLDFKKRPRTKYRCILDPRSSFRRWWDCFILVLLLMNLVLVPLHLGFFRLPGIEWELYSLFSDFVLFVDVMLNFRTGIDDRKQGIVIMDPVQIRQHYLHGWFPVDLVSSLPLDFLVLNWPSKYRNVDRRSTYSQLAKLLSFIKLIKISRLFRYGGRTEQIMFYQTTGVYLQLGNILALIFLAVHWHACLQFFVGSLMGFPPESWISIANLQNKPWWEQYSWAVHNTVSLMMTNNYGLAQKTGLLVEEWIQVMGMFCGALWQALLLGYGANLLAHKDYTKNVQRERMQEVEQFMSYYDLPEWLRARIRSHLNAQHMFLNDKDILSSLSGTLRESALCSPVYYPQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q277</accession>
    <name>A0A9D4Q277_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_019337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RBM8A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q277"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031639"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000157">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7963036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17628" checksum="0B4CAC24D4C412D6" modified="2023-05-03" version="1">MADVLDLDGGAEEFEVDEEGDQSVQKLKERARKRKGRGFGSEGTAREEIHEYDAMDTDDNDEPGPQRSVEGWILFVTGVHEEAQEDDIYEKFAEYGELKNLHLNLDRRTGFLKGYALVEYETFKEAQAAIDALNGAKILDQVINVDWAFVKGPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2M7</accession>
    <name>A0A9D4Q2M7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mic1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_018540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2M7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048641"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="552"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77909" checksum="F208210E8F4F0110" modified="2023-05-03" version="1">MAPSGSGGRAAASAIALARTAAAATYERSRSQQLPSGRKVRFVVSVVPVVVVSCRYRVSVTDRGSLPILRWRTRRISAYLGSRLGIKCLSGHPSTRSARLESATGRGRTCDDTGNALAVAVLESPSSYLQPRGPGAAADITDSNPIRFEPVSKIANVFFDDANQQVFVVRSGGATGVVVKGPDDCKSTDFRMDDKGDVVSIKFSPDLKVLAIQRSQKSVEFVNFSGTIDSVEYSQSCKGKATNILGIAWTCANEIVFVTDHGIELYQVSSEKRTLRSLKTYTLQVNWFVYQPETSLLVLSSGPLGNILHPFQFKPGVATRLPKFEVDLPIIPKPPRVCLLERDVTTAVLYGKCVIVVLRHQARTSVGGTGAEIVIYTLQKEAPPRKTDILKLDTSGRFAVNVVDSLVIVHHQASKKSMLFDIKLPGYSDGFVTYHRPVVPPSPIRPLKLKVTLPPNNSLEEVSYELYSPNWVVFQPNIVIDAKIGCLWYVTLRLEPLLAHFEDKRQLVDFLLQRSNSKDVLLGVCRRLLEKDSQFPLEQIAYVFDKLAAKEGCVDPSDMYAHCLLKVCRRRRRQYIRSLVQHQLPVPYCHNELLINVLVHNRRFHQLHQFLQYHVLTDSKPLALYPPATQLALDMLKRLGTANEEIVEVLLSQKRVLSAIRFVQNLGTSDSISARKFLEAAKTSEDPADILCRVQVLRAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q335</accession>
    <name>A0A9D4Q335_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q335"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF3">
        <property type="entry name" value="PROTEIN CBG18017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="13973" checksum="F03F2DE241FF0EE1" modified="2023-05-03" version="1">MLCVSTKEIRLFEVDKRDAATLGPLIAKNVLPGTTVFSDEWAAYRCIPGPVNANGAPLNLDWHTVNHSVNFIDPATGANTQRIESEWQKAKRRLVRNGNKTTPALMRSHLAWLWWRSVKTHVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q362</accession>
    <name>A0A9D4Q362_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q362"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116798" checksum="94621E083856B610" modified="2023-05-03" version="1">MEIAVDDPTTDEAMHASTRSLAAAPYNSLYEDVPFTFLEIVDVLRNTPKKYVTAVLVSLDFHGAFDSVWHPLVIPYFRERALPSGLYHLCTFLADRSVFVRSNAGQVEANPTLGSPQGSPLSRFSRILSSTALSLRMPRGVIVQAYADDTIILVPVPSRDALDILASEVLRRVIEWSRAAKVSLNCDKSFCVLFSHGVGPHGARTSHLVFDRRLSFFHHADYLRQKVALLASRVATFFAMQRSCVSPAHSVNVPTGDPPGSLTGVRCGGAKTTSAGRTLGVNARLPHGKHGSVAGLDACASNRPGANVSMPSSAFLLYAGILRSVPSDFGLLGWRMPMSTWRYTLRCLPRFLLCALQARGPVSLLALLPSTSTLMAPSQIPRLAQHVGRFRLTRTTSAYTTEVVAFHAALLHALTATYTLPLALYTDCLSLLQAFTSPCNAEQHVLTIRALLRRLSISVPLRVFHVPGHAGVFGNDVADFLAQRAASPHTARIEPQDAYRAASYGAILRCLRNRALLIGALRALNALPHVSRPLGLPTAHLYTEYVSESCEVGMARGPFRWGPRVLASLASQSSVCAISAGKLTTRCQAACTGPADHLLPCPPWLLHIARMFPPTLLTARSGPAAYHVPRFYLLLCNKAREGQPPLAQRMPVSPARSSPQDFGVANDCRFNERRRLDVGTRVQARAREIEEVLSRFCLDAGNRIPVNARHFIMARVFELVELCSDLGAGAASERGAVLALKDQLVETRGENTALLSEPSWPSPGPASCHRFLLPTTPQPRHSRHRNRTILPHCCSAPCRALLVSRPLGPPWPTFADAAERDVRSSNTSWTSRARGVCHALAPSTTPARDTLRLIKANIDPVEKDIKDVMFAPHPDYTSYSIADDSSAMIVTRKPPFDVVPVTRSKNVVAIYCEGPTFTFIFVSMYAPPHSPLENVLEELTTFYRWSRSPHVIVAGDFNSKHRLWDRQPPFLADAARRTVQAYADDTVILLPAATTAALSELTLEVLRRVRLWADSVKVSLNRDKTFCVLFHHGARGVARTRITVRPPGAQTALAFKDSIRILVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3V9</accession>
    <name>A0A9D4Q3V9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3V9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="248"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="727" mass="82450" checksum="E337212FD18BC6C2" modified="2023-05-03" version="1">MSGWSRMTPPTRSTGWSRYAWELFQNREDVLTTYARLQLLEALRRDPWFARVSGASLASPDAIDRVLDAFYVRFTRQYQRHLRPVKARPTSKPWFTPALTIERSAVAAKRRRFQRARDPLMRGVYRREYTTALAEFRRRIKEAREVHVRGQTLSCVRASFFSRPFKEAFGRLHQFRFLPSLIAPDGTHTSTHLESAAFLLRTQIAVDDPATDETSHALTRALAAAPYTSAYEDVPFTYTEVVDVLRNTPNKSAAGPDLISPVIMKALFRFHPRFFLLLFNASLALGYFPRCWRRARERLTRLKINRMPALLMSLDFHGAFDSVWHPLVLRYFRDRALPSGLYHLLRTFLEGRSVFLQSHAGQVEANPTLGSPQGSPLSPLLWNVVIDSLLSLSMPPGVLVQAYADDTIIVVPAPSRDALGNLASEVLRRVIRWSRDVKVSLNCDKTFCVLFSHGVGGMERVNPVVRLAPGEPTLQFREHLRVLGVIFDRRLSFFPHADYLRQKVALLASRVATFFAMQRCYVRPTHKLVMYRQVILPALTYGSPVWWSEDHVDCRLQARMITVQRVALLALTRAYRTTSTAALQVLMHAPPIDLELERVNAEFRLFTLRRHIAFGACRRFLQLPPLGDVASCGCCTFPRHCQALGGCDPSHSLPWVCSSGPLGHSGLPSFGYGHHLLVLVRDLRTWTRGQDSTLHLLRSPSCLDAPRTVCSGACWQLVCVAAVPWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q405</accession>
    <name>A0A9D4Q405_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_001548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q405"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041598"/>
    <dbReference type="OMA" id="FVIMFFH"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7967671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="32893" checksum="65AE86FFBFFDD9AD" modified="2023-05-03" version="1">MSTGGAMENSTGTGSAEDFFRRDPRTADWALVGSKQFIVFLIVAYVYIVKIGGPRFMKGRKPYDNIKPLIVLYNAAMVLLNCYFVGAFFARTYWTGRYSLFCQGIDFQARDPLTMSMLSHVWWYVMVRIADFLDTIFFVLRKKDSHISFLHVVHHILVVFNGWYGLAYGADGHSAFGIIFNSFVHVVMYSYYFLSLLGPSVQKYLWWKRYLTQFQLAQFVIMFFHMTIPLFVKCGYPLAHIFITLPQGVFFFTMFMNFYIKSYCNRRRGHQPRDEIKSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5S9</accession>
    <name>A0A9D4Q5S9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5S9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036659"/>
    <dbReference type="OMA" id="HEFGKHD"/>
    <dbReference type="OrthoDB" id="72976at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="347" mass="39608" checksum="97A4C72DA8E9E4BD" modified="2023-05-03" version="1">MNLQSLFEDFNPSRFLVHCCLLAFTLLFSLRLDGVISWNYWVVFLPLWIWKFMVIVGAVVGSYVWWTHPQYRNEGDGQVHYQAMVISLFLQLLLLVFEVLACDNLQNDRHLWTLVFIPLIFISVLSIAVCIWAVKHDRSFELELFCSVNVLQFIFLALQLDKFIQWSWVVVFVPLWIVMCLAVIGVLYAIIFASILLRTPEVSPEQRRTSLHSAVSYSMIVGPLLVFLVLLSNKLDTEDSLGYTETCTPLYFTFLVLIFLSFGSKGGNHWWFGIRKDFCQFLLGACPLLQEYGNISYSLHNNEADSPPSVDAVAASEVKSIPRQRPRSSVLAEPRPIVAALAIDTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5X0</accession>
    <name>A0A9D4Q5X0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_010206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5X0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035128"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7968620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="314" mass="35089" checksum="D2408CE580C02702" modified="2023-05-03" version="1">MAGGYRYSAALDKTYMEQRWVPPSTPTVQPVRTVPIIRATPAPSASDPLRFIKIGQAPLGKQAREQLQAYESSVRNHVQAKLDEQEEQWQTNLDEWKSRRRKASERAFQRVQDAKQLFPDDGRKEPEPEPTLTTSTELLSEYSTREEFIPSNKAARPAPAARPSTKGPKPPVPPKPMAELRRKEFLPNAETGEQDSGRQGHGAAMVIESLQLLYHLACFRCCVCQAPLGNGLCGTDVRVRNTKLHCTDCYSNDEETCKSRGGSEAEQGLMMEVINGEAPPMAQIFFHGWYKTCINRCRVLAADPPKQLFSCTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q609</accession>
    <name>A0A9D4Q609_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q609"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035424"/>
    <dbReference type="OMA" id="KDGWDAS"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43564:SF2">
        <property type="entry name" value="BLR6059 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43564">
        <property type="entry name" value="KYNURENINE FORMAMIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20570" checksum="C420E5A7649593E1" modified="2023-05-03" version="1">MEEPIHGGTHLDSPLHFYKDGWDASQIPLERLLFLPIAAVDVRPRVQLNPEYLLSVDDILKWEYIYGRLPEGCLFLVHTGHSKHWADRMAYMGIDRNGVKHFPSLHPEAARFLATKRSVYGVGLDTPSADAGDGSAAHRALMSINVFVLENLVGLEKLPARGAYALVIPLKLDGASGSPVRVVALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6H0</accession>
    <name>A0A9D4Q6H0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6H0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028480"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="6">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="326"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7968885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54878" checksum="24A34D991EF9E4F1" modified="2023-05-03" version="1">MLELFVLRFSKFTPTTGHRVCGAHFEGGKKTYMNRVPTIFPLRPQKVERRRPLIRTQPELPNSPTVAPQHDPEVSGSAITSSSSDSEDTAQQSTLLMDHAYSSQESSYDQLAKKVACQNNIITELAEKAEAAYAHVEELNRQLKRSQQDHAEAKKLCDRLQQKNRCLRLELSCMQKKVKRCKAEATQKIDITYEALVEDEKKLRYYTGFTSRKSFDSFWSLLEPDAKKLRFWQMKETENEDRNFILPLKTQLVLVLMRLRLGLDGLDLAYRFGVSTSTVSRIWVTWLDFLDNRLRQVPTWMPPHLCDKYRPQAFTDKGYTTVDGILDCTEIFIETPSSFRVQSETYSSYKKHNTAKGLVVCSPNGFVMFVSDLSPGRLSDKALTKASGVLEKFSPGRSLMADRGFTIEEECKELSLHLNIPPFMEGRPQLSEADETETRLIASVRIHVERVIRRIKTYRILSQVFPNSMSGQLNKKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7I9</accession>
    <name>A0A9D4Q7I9_RHISA</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017392</name>
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    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7I9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043780"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="22700" checksum="7871E5C37052D247" modified="2023-05-03" version="1">MRKRNGESPPSSGGGSTRESLWQKASSLRQSLRGRSSRHDGTPGSSGGSSNRRPASLYLADSSSSSRCSKSRQSLRREWGSQRDLSREKRHAAASAAALAHPPSASQQPQHQQQQSCDGGSDHEPDTAWSSTWTLPDSTSGSVPLPPKQRSPRKLTKDSGYETSGGGGNHGEPDYVNREWVSRVPSPPPTTSGQTSGTASGPPSIGPTSPVGAGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7P7</accession>
    <name>A0A9D4Q7P7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7P7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="13007" checksum="9FCAABE0B3C92AB4" modified="2023-05-03" version="1">MASTWELLELAERMGLEGPDFRAWYEERMAREREERAAERKANKEKLESELRAKMEHLEVERRALERRLEVAMEEKTHLESQSYGQVVDGCSDSSFPWKTSSYFKKPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7S6</accession>
    <name>A0A9D4Q7S6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7S6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030388"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="249" mass="27425" checksum="3CF8796174C14907" modified="2023-05-03" version="1">MPPVYGNSMEVLRELVRSVVREELQKQRLDQNAPMISSLADVIREEVRQAVREPQLNTQPELPLQQQPRMSYADALLRGPPGRVDVAAATPMQHPIDLGRCARIGRRCVSAGCSSVCQHGCPCGTQAEIAVWECRDTIASNTDAYNVGPLLRIRPVVRRLPLTDPTAALLLGHRRPNAVVPRRLNHAAIHRRRTTSRPGRKTSSTRRRPALHAVRATAATAGARTMRAVRPAACAPRPLSASRHVPCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8Z3</accession>
    <name>A0A9D4Q8Z3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_011632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8Z3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046977"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="258"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="841" mass="93239" checksum="0615B973D83923CB" modified="2023-05-03" version="1">MQQTKNASPTPSSRTPQAKAQKLKKAGSRRTKHGSPESRRSMRQVADERDDFDMRPPDSGVFSPSIPQQTVQGHAQDAGVRVHTARLPHLGRGSPLTRPTDGAPQTGPQRRSPSTTARDTAAAGNLPMSRDGYADVAQSPASHRSGPGSSTFLAWSPRTHSPSSPSGSAAFLRQPAFSSPLLPQDPLYDVTSKRARSIGPLWATLCVLAVVVLAAVVAVAIMKASWYSVAPLSSPCSTHACLAYSTRILASLNESVNPCKSFTRFVCDGWRKAHRSDVWDLQFLHVLDRLTASLKDITVPPTGQNEEQRAAAVYRSCVSLLEGSRDELPAVLKALDDAGIVWPQPSTGADVLYTLLYCSMKLGWDVLLNFYVVANGNGSAVELVAAPGRLFSFPYEKYLRLEAAEDRAAYFEFLAHRLRGNGTVTLTYNQTQGLEEHALATLPYHITSTVRAGSVEGFPDTTDIGLTEAKWMAVLRKLDANLTKVSSLMTTNIRYVNVLLKLWRSYDSDLFHELVSWFTVQVAALFANRELIYNYYDDKYNMGHIYYGIFCAARAMFFSRQALFARYNADVLQGKAGSIARELTLSVRNAFRRRLSNWTYFDENITVVANWSSLATVFSNMEESSEENETRIRGQLPDMTDSFLKNWQHSVLVRNEPEVEDMLQSMLHLNYYVISYEKRDFQLMPYALSFPLFDAMLPSSVNYGGFGLEITQAMSDLLLGFYETSVIPQNMSLAECLIASQFGGVFDPQFYESQTFGLNALVDAYELTGRTSDNALQGLEKYRGLPMLFIAMCYFQCVGSIDEGDGEAVCNLPLQQLPQFAEAFHCAPGEPLNPAKRCELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q988</accession>
    <name>A0A9D4Q988_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q988"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="16983" checksum="5CB0187758527627" modified="2023-05-03" version="1">MVPHHSPLPISILTAHDQHQAPPTSSSTKASAAHWTLLGHGGTSGMRTSDDPFVCLVQSGNCCTTVWQQRASAPPTPFRAEVSRDAVPVTSLSAKFSRNKSTAQVLPFLCDRLPQRIGRAAAVGSCGQSFLQHAPDIFYGIQVGATWRPLELANSMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9E8</accession>
    <name>A0A9D4Q9E8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9E8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21959" checksum="B64E0C08A7F2DD2A" modified="2023-05-03" version="1">MDRSGRDLGLLPGSDSSSGRRRLQRQGIPETLMPAALKQLNHFVVEKLADLERLAKREAVSTISRSACKGSTDTLESGSDAWEAVSTISRSACKGSDTLEVEVMRDGDCSARDSRNPMPAALKQLNHFVVEKLADLERLAKRRRLQRQVIPETLMPAALKQLNHFVVEKLADLERLAKREKDTGIPKCGKVQVKNRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAN8</accession>
    <name>A0A9D4QAN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_018902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049275"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="19132" checksum="2A7D9480DB1B7E90" modified="2023-05-03" version="1">MFYHISLDHEILLHPKYFGPQLVETVKQKLYAEVEGTCTGKYGFVVAVTTIDNIGGGLIQPGRGFVVYPVRYRAIVFRPFKGEVLDAVVTQVNKVGLFTEIGPLSCFISRHSIPSDMQFDPNSNPPCYRTQDEDIIIQQDDEIRLKIVGTRVDASDIFAIGTLMDDYLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBF9</accession>
    <name>A0A9D4QBF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_019465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039245"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042936"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038608562" description="Serpin domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="7">
        <location>
            <begin position="311"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7972956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="495" mass="53468" checksum="2A9DBFDE425C7730" modified="2023-05-03" version="1">MRRILALLTRLVSFFFGWLPVYGRRERLAGDGKRVLVSGCDSGIGLRLAQRLHEAGYRVLAGCLSTDSDGARQLSKLRDGEYPVRVLQLDVTSDRSVHRALILGQVHDEGLWGLVNNAGVCVLGEFEWMTPEQVERTMAVNLLGTLRLTKSCLPFIRRSKGRVVSLSTVVAAAPAMPCMSTYCVSKTAVESFSRCLRLELARHGAHASVVRPGDLAKHTGIMKRQADDNKHALGSRRPRALYVSDSGLWPLFLRTLSVLPTAFSDAPLGHRHRGGPEAMTTGSASPLRTPLGSASPATPGTPGSGRPFCTLTNFGLKLVAHALNEAPDSNVCLSPFGVAVALGMAIVGSGDATTAQVVHAVGAIDSNNLYRTCEKILSMLNSSMPNTKVSLGSRLFVSEDIPLLPEFKETLAETFSVDLGRINFKDNPQAAAQEINAWAAKATDGNLTHLLRDGDVSERTRILMVSAIYFRGIFSEPFCGPVKAPFHINAKETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDB9</accession>
    <name>A0A9D4QDB9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030484"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="456" mass="51016" checksum="65C06AF0E53DA3C9" modified="2023-05-03" version="1">MNMADGGTGEFDTTYSEVEELFRKGLPKDDAARKQSPPNDHDCPKHGIALYYEKISEEDATVLRQMLSTGPAVRKLYISKMSLAAFRTAFDELEVSSKLENVYFGVDCQREDFSINLSVAFGRLWSLELSCHNVGSGFAKELARYIQESESLTKMVIWDSCGGDKGAAIIIKALRKNRTLKKFTLAEMELSPDMLITFAEMLATNSTLKQLDVRTACSVKKDKVSWLLQRNRYADVFKRLDITWPEQLLPELAVLVRSQACCSELAVSVASIVDDEALRKFSEAVATDTKIRDLCVYFVKATDDGTGSALEDTLKKRHDAVDEREDRDGAIEDTVDALCDGIAPGKRMRIHRDISSNKRVKHDNQRQLVGILGAVKKNRSIRKFAISTELVTPEMATSLSELLAVNQTLTHVQVCIIQEISSNDADTIRRGLRKNSTLTHFNVSSEENESVTNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFS3</accession>
    <name>A0A9D4QFS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_000418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040532"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7981643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="243" mass="27472" checksum="5AAFC31A90B3FC3D" modified="2023-05-03" version="1">MRRRVGGVGAIQKQQLTQARFKDRGTELAEEQLQQMTRQMEAFRAKLQGFAARHKNDIRKNPQFRRQFQEMCATAGVDPLASSKGFWADMLGVGDFYYELGVQIIEVCLATSHRNGGLMSLEELRERVTKSRSSAQRQEEITQDDLLRAIEKLKALGKGFQLISIGCRYLVQSVPTELSLDHTTVIKQAGTTGYASVGSLVQDLGWDNDRAQKALEDLLKEGLVWLDTQAPKEHLYWFPGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFZ9</accession>
    <name>A0A9D4QFZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040867"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="186" mass="19890" checksum="8A404FFCDD759134" modified="2023-05-03" version="1">MQCHRFGHLSDACVSTYASKLRSGQSSAEEPHLDHLMDATEVGDATGEATGEAVGGLKEDQHLSMEAMPSSHNNTAKDVSEDISDEITAGEHSLEELKEKPPDDEGEEEAMDSSQTRKRPAPLSDEARTSASDATQQMSSCGPRVVSFGDRGSRRLCQRPQESAAKKCKGGKTTGCPVAKGDKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGN9</accession>
    <name>A0A9D4QGN9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_003360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGN9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041059"/>
    <dbReference type="OMA" id="TEQSFDK"/>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06403">
        <property type="entry name" value="PB1_Par6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000031">
        <property type="entry name" value="Partitioning defective 6 homolog alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000030">
        <property type="entry name" value="Partitioning defective 6 homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034868">
        <property type="entry name" value="PB1_Par6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PB1" evidence="14">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="161"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7982168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="35472" checksum="1FC4DBFC08CEDD7D" modified="2023-05-03" version="1">MSKPLKNLHHHQNGSILEVKSKFDAEFRRFSLDKSELSRYDEFCRLIERFHSISEVPFSLCYTDPIHGDLLPINNDENFARAVQSARPLLRLLIQRKGDSREELNGFGGPGASRKKRFLGQYLLPAGVRTARPALSISLPEDFRQVSSIIDVDVVPDTCRRVRLVKHGSDKPLGFYIRDGTSVRVTPHGLDRLPGIFISRLVPGGLAEGTGLLAVNDEVLEVNGIEVGGKTLDQVTDMMVANSSNLIITIRPANQCSVGTLPRRGSFGRSSQMSHGSHNSNPSVVSDDDRLDEDEIRDHTAGFEGLDETPPRSTHDGVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGV4</accession>
    <name>A0A9D4QGV4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_001175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGV4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051432"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="11">
        <location>
            <begin position="353"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7981820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="446" mass="50369" checksum="2F2E223678E65E91" modified="2023-05-03" version="1">MAAYMTNRRFIIETAALLQKQQTETKAVCLFPTDMPVHLPVMKKCEAELADGSKQVAPMRIMYAVNPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELLKNYDGKVHGDRDAGSVNDELFLELVHALMAYDDDPGSSSQAFHPAPSQYKRKSCDMKLDTEPCGSHCYLHLDSVKARLQAKLKEERESSEQRKMQKQISMDSGNEASGEDSNDSTRTNSKKSDSSEKDLDKPAQMTVNSLSGKSFESKASRLLASLEPVVQPSQEELQEEWSGAEQSLFRVLWRVFYGNYCALATLILSKTCAQVYAFAQRELADLPPEEHVHDSTPPRKKKKKHRLWSMHCRKIQLKKDSSSNHVYNYTPCNHPGQACDQNCPCVMAQNFCEKFCHCNSDCQQRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQTCGAGVFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QI33</accession>
    <name>A0A9D4QI33_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_004389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QI33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045567"/>
    <dbReference type="OMA" id="MRIMACD"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="446"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7982405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="604" mass="65246" checksum="A106E8D9DDB1A5F9" modified="2023-05-03" version="1">MADCERVHNLNSTALQCAFVRDTADCHVDESWIEYTTFAYCGPLAPYFPIGTEVLWIALLFLVLGMTADDFLCPALVVMSRTLRLSESVAGVTLLAFGNGAPDIISSLAGIEQSRPALVIGELLGAGTFVTAVVAGTVFLLCRFELEPDSFLRDTVFYLAASFWTFYLFYDGGVTLGHAVGYLGLYCVYIVVVLAVHFWKQAHPEEVPALPDVAPKVVLEVPAEAQTTSHLLMPPVPPDWVQERRSSVSSVASNGSAGDARRRRSSTGSLHRHHEHAIAAFMQASHEASMERRISQCSQPPLEPVVMSEKTPLLGATGTSAVAQDTSPWAEFLSQLVPWDPEEWVERGVAGKIYDVVTFPVRFVLVLTVPVVDYENAKNNWCRPLNALHCVTSPFFVVVVLGRADDYVADKIPSWVLALLIGGIAATLVWFSSSFESAPRYHFAFGYAGFILSVLWIYGVANELLGLLRTLGLVAGVSDAILGLTVLAWGNSLGDFVTNVAVARQGYPSMAMAACFGGPLLNLLMGVGLPYTVKLAPVGFGARLPLELTPLVSTLYGGLVASLLLSLYATLFCRYQSSRIHGASLLALYALFLAAAVTIETTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QI86</accession>
    <name>A0A9D4QI86_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QI86"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="34943" checksum="1A63F09068A7DBC2" modified="2023-05-03" version="1">MDKRGKRLARKLENRSGGYFDFLPLLRAATFGILFEGACHDTAPKADEEIAEVFGEEGDEPSDDKVGSGFVLVDFRDGASMRELDGATKDLGGREAKDGKAEKTRKRRKRKKKRNHDEQRVGLGAKENMAIVEEAIVVDAVTQVRANISEPNPDNEREDRTEEETKKTEVGKPGADSKEEEETKGDAAPPAKKAKAEPARTRPQCETKSGGARRVCSLEAAAKEGEALLRELGHKDSSVPDSACRRTRSQTRCTTAAPAVRKIPAKPARGARKGAASKSSKKEKSEEEEEEEAASAEEASTTAVYEDRSASSIEKKGGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9D4QLH5_RHISA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006776</name>
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    <organism evidence="2 3">
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        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QLH5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9328" checksum="DEF38833CE61054D" modified="2023-05-03" version="1">MLTPKLAFDCAVIVRSVVPGKRTSLAMAPEDAVAEVGGRKVDRPSDEYGAGVDAIKSQTEAVRISGPYPQDECGGSQWAQVRKVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMF9</accession>
    <name>A0A9D4SMF9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002148">
        <property type="protein sequence ID" value="KAH7931626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMF9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="90" mass="10216" checksum="A141CA5F29BF0300" modified="2023-05-03" version="1">MARKFPSRPFDGLKSHRRTDRYQTLVKELLARSDGTIRGGAEQEESEPLSEDSRASMEVEEPIDPRGANAEELMTLVTKPPPRAFQAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN77</accession>
    <name>A0A9D4SN77_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN77"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052201"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18800" checksum="7F3F985A0A26657B" modified="2023-05-03" version="1">MVLSTLAKNTMNSYKLNDEFKMNDEFLQTRPDFRSRNTTLPFYHSTILPTQREGVALCLSPQGRRKGEALVRFENSEHRDKALKRHKHHIGQRYIEVYRATGEDFVNVAGGNNNEAHSFLSRGGQVIVRTRGLPYDCTAKQAVEFWCRRETAARARSRTRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP20</accession>
    <name>A0A9D4SP20_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_014963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transglutaminase-like superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP20"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053551"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09443">
        <property type="entry name" value="LIM_Ltd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000108">
        <property type="entry name" value="LIM domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19444" checksum="931A5EDDEB6F960C" modified="2023-05-03" version="1">MNSYENTCLRCGQTVYQVDKVGPLKDFTFYHQGCFKCLVCGTKLTLKTYFNNQQSQEDKEVYCQNHVPKTGPGHLDGMSVGIKAALSVPKTNNLVNDQIRGSGKGTFDADALGIKSALTKNHQQHHEQEYKHAVNRAGRFDASALHITHALNATKVHRGKVAYERNMDEYLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRQ2</accession>
    <name>A0A9D4SRQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034618"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14905" checksum="A28C84852498A85A" modified="2023-05-03" version="1">MKENEGARLTSNCHGRLHARRLGYASLFVYFVTFVLVPKPARSSGPRHSTMDQLRTKRSFARTAITKALSTFDALLADSTTLPGRLKEILGLIVIKNAQLIHFDSEIQAALHDDEVEAYLTTAYEYEEKASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STG3</accession>
    <name>A0A9D4STG3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_002219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027427"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="203"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="9">
        <location>
            <begin position="406"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7946637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61316" checksum="6D1A7AAAF918FEC3" modified="2023-05-03" version="1">MNSPDNAVGVYCPREQAHRFPADDPALDMARKRAMRLAVAAGAVAALLPLAAAQLSFWHLLANRGGARLRDPYEALDALSRVGYSALVDPDEEGSGSDSPLDTKQALEYVAKLGWSDVNIAASYTTTEVCTGIVRAYKDDVGYVMRTTRSSPNEMCTLMFGRTCGNLTLPEHVWEIVVPEKSTSNRPAPEERAQSRDEPGSSFRVLQLSDTHYDPEYIEGSLAACDEPLCCRPASGEVQNDTDRAGRWGDLRNCDLPFRTLDNMLVHIGSQGRQAEFAYWTGDLPPHDVWKITRAANFENFETTVTTIAKRLPGITVYPVVGNHEAVPPNMFPETDHSDAKVAEKSQWVYDTLAEDWKVWLPEDALATVRRFSDTVVGQFYGHTHYDEAIVYYSSADRSRPFGLAFVAPSVTTYSFLNPAYRMYDVDSESKLVTRHETYSMNVTEANQDGGEPHWRLEYSTEDLGLAQAGHEDWAALIDAMDTDQARFIQFVRYTTRLDDEDTRCDDACRERLLCRWRTDRAHDYSACPRDPTADRNNTTGSKEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STP0</accession>
    <name>A0A9D4STP0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STP0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="71" mass="7990" checksum="A423FA06FC5C9425" modified="2023-05-03" version="1">MPKPQVRLKMLWQCPALNASFGSPATEEDWINHLRSPDRALQHQAVQKAQKVAGELRLPVPTWAEPPGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUB5</accession>
    <name>A0A9D4SUB5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUB5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033938"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055121">
        <property type="entry name" value="HTH_69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22979">
        <property type="entry name" value="HTH_69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn-helix" evidence="1">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="593" mass="66180" checksum="F5CE284B1F0A355E" modified="2023-05-03" version="1">MTPRKKAEGQTTIKMERVARQALDKGNVMHEAGGDHRGIVINRLASRDDDDDDSPEISLEFRVFLTNVVTEVHTRESRELKFWFKPGVTKNDQRHSAQEFFKELVSPSDFPRDYVGFIKKIMKLMQIKYVNMRKVEIEMRQLENITEPPRRPMSLDDSTLEAKMELTQEKVLEIIESAYPNPVSLADLSKNTSHAPEEVHLHLRELLSKNLIKEMESGSFTRVVQNDTGKEVKMVRQMPTVHGSQQPTIAIITAQYCEKLAVDVMIENKNTFVRYKTEGESNVYTLGNIGAHRVVSTKLPAVGHSRAAIIAAGNTTTRLLGTFQKVDYVFLVGVGGGVPHYTDHTQHVRLGDVVVSAPRPVPPTTNGNTNGGTNATTGQHVYLFAEQQHRSPDHPPGSREPSPSELAYSVKTWCPPELRLQELAEKMWQQGAADPELRPWERYIEDGLRALADQESDFARPPESSDRLYMSIGAKDLIEVAHPAPPPGAPDHRLPGRPVVHFGSVASGLGSVVRDDTRRHALAEEHGVRAFDTGFDTVVESIYGNRKDHYAFIRGIADYKDGSKGREWQPYAALAAAAFMKAVVCALDPADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUN8</accession>
    <name>A0A9D4SUN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54093" checksum="31750514BD2F7298" modified="2023-05-03" version="1">MMQYAVEGETITPEEFEAGEWAPVLKAQDRFKKSLYGDNANNTPCETQAGSDGRKTHGAEQAKRGKAPVWKKRGPFLKMPATDFKVVYRPQNWDLSVVTARQLGCALRAAARLTSVTAAEEDLVRVNGTNNTLTVSTPCMNRSGAYATVKTLKLGDHDLPVSAYVAPLENSVRGVIYNAYDGCPVEEVRAGFLKKNEGMEILDARPLGKSKAIQITFGGKRVPRQVTYWNCLYAVIPYRNLVETCYNCRRVGHRADVCYRPKTNLCHRCGKDHPAPPEGEPLTCTPDCIVCHGAHHTGSRNCKFRLARKPPTGRQQSIERESQPGKDERHSRAKERSSSCGKRSTSKSRDRSSSFPPLPGGGGGEESGRVASPDRNARDTTKKVSLSNAGSQNETARERELETLVQQQGDLIKKWKLELQRWNALLKAANDKGYRHQQYRAYRKRCKRRLLAYRRVRLWKWRIGGQSRGRCRQMRELMQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV61</accession>
    <name>A0A9D4SV61_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV61"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039570960" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="9985" checksum="683EA07F8BF98C29" modified="2023-05-03" version="1">MGRGATASGVVVWTLAVSLAARPVRFPVGAFASKFGMTTRDRLPADLARSTRPRTATDTASMERQSSLACDLLVMETSMPVTPGLPAAETCAVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVA2</accession>
    <name>A0A9D4SVA2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_019186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVA2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7952133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="450" mass="50202" checksum="CD0A78F6804CF757" modified="2023-05-03" version="1">MSTVSGDDESSPDEDVGQPLFLTPLIEAEQFEEALQKSKVGNIGDLPDVLSYSGFITVNKELGSNLFFWFFPAKENPETAPVSLWLQGGPGTSSFEGLFVEHGPYYIDDNGDPQLRDITWTRTISMLYVDNPVGTGFSFTQSNEGYATDQDDVSRDMVEMLQQFFTLFSEYSSNDFYLSGESYAGKYIPSIGALLHEFRDQLRVPINLKGIAVGNGMTDPITMLIYGDFLYYIGLLDKRQASYMREGCNRAASMICEEDYLGASLIATSLILGTVAGTPTLFGNVTGYEYAYNYLLTEKPESHSRYKTFLKTPTAREALHVGQVEYDGTSTEVVLYLAADLMKSVKDKLAILANNYKVLMYSGHLDIIVPSVATETLMYTLPWSGSEEWSNAEKKIWRSPDGESVRGYAKNAKNCTLVIVRDAGHILPYDQPEAAYDMITRYMNDEPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVN1</accession>
    <name>A0A9D4SVN1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_004430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030027"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="631"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7951036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="722" mass="81815" checksum="F15EB61AF2B9EDFC" modified="2023-05-03" version="1">MRKGSRSSIESAKKAKSASHHRSQDSSGSLAPDDGYSKMPPAFVLVANPNAKRRLLQLAVAATVCFAVGLICIVAYVFLTSPGKTVGICVSDSCLEHAKRLLSSINASADPCKDFYAFVCGGWQRAFPALSVLEKMNVDAKQNEIMELNADTWRVGEASQLYRQCYEPSKVHVDTNIEALLQFMDIVGLVWPVRDVNDSLLHPLEVMLYMAAKYDTNFQFRLEVATSKIIGTILVVRRRYHSVVWEHRLLHALNLEEYAMVIRDHMNTLRLKNVQCNTTLLRELETFFIEATSYESGEGDQSWLTISELDSKTPNIRGAQWHFLLNRQHRITLQRTWNPKDWVVIEDSAILTKLDELFRTYPDPHILMGTAWMFIQSHLWVAAGKPDLMFRDNFQEKVQLACLEYVNSLFGLLASVEYLTRTYPTSEVRRGVYSFVRSLKNEFVSTLKSTAWIGHESAEKAEQKIKNTDLNILPSEHFFLLSARAGLYGKFPDINTSAFVESWLYTAESYQKLQNHARFYDVYQKRRTFHRQPYEYTYLRNSVDAATAALDPPLFYRGGTFAMNYGGSGVLLAKKIAKAIDPVGTTVNSFGENVVWWGTAHSAEYNRRLNCKLGQAAGHNAMGVFPAIPALEVSFSAYKTAVKQEGTSGPMVQDLRIRGLEEYTDDQLFFMTYCYALCSKEGDTSSQQECNLPLGHFSRFADAFYCPEGWPMNAKSKCTFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWG2</accession>
    <name>A0A9D4SWG2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_014843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWG2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029817"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF3">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7951891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="24511" checksum="D9E179DC46C20CA2" modified="2023-05-03" version="1">MLENGVVLLFQTAAAKLQKEFKNYVLCIKSLQLASKALMDTLSEIYEQEWVGHEQIPVKAQTLELLWDDYHRKMNDQVMIPLNSYITQFVDVRGRIAKRGRKLVDYDKCRHSVESLRNSAKKKDDYKLGKAREELEEAKQMYEVINNELHEELPTLYESRIPFLVSNLQTFFTAESTFHAENAKVFSFLVDTMQKLAADSERLGSTIGSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYL1</accession>
    <name>A0A9D4SYL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYL1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12129" checksum="E01F2B9A9882F31F" modified="2023-05-03" version="1">MCEHASPFPAMYEQCAARISPSVTLPQEPHFDGRLDSGLRMVTCFIRGSLPAACHEVVAANGLPSFELLSRYKTRPQDHKFANVGGIDERSQIHIHYAVACLPRARVHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ71</accession>
    <name>A0A9D4SZ71_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ71"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="9412" checksum="D6CDF9418F6E7C2D" modified="2023-05-03" version="1">MTVTRRNGHAAHPDPAHGPGVVLEAGRMEALMRADPGPDPRVVGPNRGADLARGAGLGTARKGPFQGESEPALQGGTWADRVRSGGRPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZL5</accession>
    <name>A0A9D4SZL5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZL5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044184"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF67">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11330" checksum="D8F1090407E09DA5" modified="2023-05-03" version="1">MGCDEHVASHTSDEVNRVSVYTASEAECPASWRRCDNGACIEPLLWCDGIDNCGDSSDETEDNCAPSTILSIPGIVIIAVIVVLVIIAIGVVVYVCKRRRAYRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T100</accession>
    <name>A0A9D4T100_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T100"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030301"/>
    <dbReference type="OMA" id="VVTRCRG"/>
    <dbReference type="OrthoDB" id="6499194at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="580" mass="62527" checksum="51E95D1EAC403DC1" modified="2023-05-03" version="1">MAAAPGKQLTPAQSSPSGSQTPWLCETQLPFGDGAFQLMNVFSAAIVLGNYLLHSEIFLLTAGVMDHWCRRPDSFANLSVDEWKQLAIPVDKNGEYSQCTIREPPDGGTEARVVRCTSWEYDYTQYGNNIVSAWNLVCDRLWLIDFARIVYAAASVIPLAASASFADSIGRRTAIFITIPVVLISAVASAVPNDLQFFMIVRAVVSASTSVLVPPAITLVTDASTIDKFPAYVVAVSLLSFILMPVTVLAAHLARTGWVAVQLILMIPTCLLMLLYYTVIESPIWLLATGHMKEAERVALRAAKMNNVSADVCHELMARQITDLRARGWLTAESSGLCSGRLRTRTVLMCCMSTALCFGFDTFVTKDGIPTGDVAASLSFALSAVACVTTIPFVKHFGLRNAVVGSALGFAVTLTALAGTTYGGGGQTLNDSLVVPMKAAGNVCFTFFIVMSLKSLPVVTRCRGAAAVVASSRFGDTLARLTPRLFGDQSIAMGLAISGALMSLFVIGAELFPFDSDYWMRQHLSHESSSRRPSEGTKRAMRDTLVPLPKEPIQHRQIKTKDRVALSRSTTQPAGEQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T111</accession>
    <name>A0A9D4T111_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T111"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15015" checksum="67BDDF0572379C97" modified="2023-05-03" version="1">MTSVDVAKAFDRVVHPAITHGLRRKGIAEDFCLYIADFYSRATTVLTCGAHTKVAHPSRFVRQRDPHSRLLFNLVLDDFFEDQPAHIAFESEGLSVSAMAFADGIILTASTRGGLQCELDSLDAYLKGRGIEANAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T298</accession>
    <name>A0A9D4T298_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T298"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="310" mass="34943" checksum="AECF06C9E8B6F5BC" modified="2023-05-03" version="1">MAASKETHARTVLMLSHLDTERIYPRVNEFPIAVKFLVLTNRTIRCEFYIYYDKQKCGVPSEQKSYFTAMRRSVYLPFLSRVQAVHRSWIMKISKLAKYQLIISSENSSQTLRDFPEALCNVAVISSRGINVPEDRYRRCGLRKDVTAARFADLKVVRPPKFPKNQKYIAGDLRRGFREDNDKPEALALLDVYRALNNTVHVTAVKHEAAIVEKSVDLLLLPSQAAAYRSMAVVSWLLGMLILGTYVQTSITAIRVVPSASPPIKTLEELSPYADDDEEVSAASQWGLVPSNDLCTLLQVAAIHALNPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4D1</accession>
    <name>A0A9D4T4D1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_020930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043591"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.180.10.10:FF:000008">
        <property type="entry name" value="Odz, odd Oz/ten-m homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF72">
        <property type="entry name" value="TENEURIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23538">
        <property type="entry name" value="Teneurin_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="855"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1057"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="668"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2913"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="2921"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7969662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="2938" mass="324906" checksum="E008761B27F99F76" modified="2023-05-03" version="1">MSPTSFRHHFTLIIESVMRPGDLISAPSATAQRRAASLAPESGPCGATIDSPPDPPRGFRPWILAPPALRQQYSSLPPPPPSAGGHQARQQQRPHAARQCTTERRAAGRPVAPPPAAGLSSSGSESPDEEEELDDDEEDEEEENRSDATFTGSELALARDTTLVLQSRRIPAIPPRNLSMGRTGGGGGRPPAATAPQSMLAQDQDPAEYEPTSCLARTPSGSLFIPSDLTKGPGSPQSKTDFRTSNIIQDETKTNPDRLGYGGAATGGAAVGAGMPLRNHVRHPLGPGHHFPHSRMHLRKTLSSRCSWKCAAIAAFVLCLALVIALVYFIAVPFLSWQGGQHRCPVVIDDAEASAAGENYKSTYHRGPKADHRPDGARQRRRRAALEHPTLAPLPTDTPTNIIEGSGEEPPHIWQPHESESSSQQRNRGSRSPAHESEFHADTVIVIPEDPPETRVSRMRCVCKRSFGEHTKASPPSTPILWQDDSQASRSPPIKRSGAAEASTAPPPPLPGPMALFGSTDHNATSNEIPISVPDNDIGDGGVESDVSGLDDARGLEKNVVEDARDGLQVPEQGADSGGRGVSPPPPPPPPPPPPSSVSSESGEEASNEQGLSGADASEFITVGNGASDVPSPSPSGRTDSGVDTTNLNSIEHDASAEMDVEPRLVADKEAGGGSGHSKAVPTTTASPTEWPPDLGPSLLPPKTLPPSSSESFADMSIGKRHSKVVASYGHWNVQFNQQEPGLVKFNYTLPTGASVGIYGRRNSVPTHTRYDFAEILSARDRRHRKAAKESFSMEFIHFLDHGRWYISVYNDGDQQQEISFVSVATDVSSLPCPYDCHGHGTCNMGKCDCDQDYAGESCAYRVCPVLCSGRGQYTSGECVCQPGWKGRECQLREDECEVADCSGHGDCLDGVCRCFPGYKGVHCEEVDCLDPECSGHGVCVSGMCLCRKGWKSNDCSEPDSDALRCLPDCSGHGQFDLDLQRCVCDDQWTGPDCSQEKCDLDCGPHGRCQGGECICIDGWTGLKCNEKLCDIRCVEHGQCKNGTCLCIQGWNGRHCTLEGCPHSCNSHGDCIMSDGDWRCKCHNGWDGPDCNVPMEKTCDDRIDNDNDGLTDCADSECCSHKACTKNPLCFSSSDPLDILLRKQPPAVTASFFQRMQFLIEEDSVQSYAKKEAFNDSRASVVRGQVVSSSGSPLKGIRVGTAGDGLIGFTVTRDSGWFDLMVNGGGAVTLQFRRDPFDLHERTVMVPWNEIVVMNKVIMSLSQNKALENRGLACSDHDYDTMRPVVLATWKHGFQGGCPERSAVLAESQLTPETIPLTLRLIHLKISIEGILFEKKFEADPGIKFTYAWNRRNVYRQKVYGVAVATVYVGYEYSNCPSVIWEVQATQVSGHDMSISEIGGWNLDIHHRYNFHEGILQKGDGTNIYLKNKPKVMLTAVGDGQQRPLHCQQCNGIAKEQRLLAPVALASSPDGSIYVGDFNLIRQITTDGKIRTIVELSAAQVAYRYHLAVGPADGRLYLSDPERYQILQIVSYTDIPDVKNNVMVVVGNGAKCLPGDKMLCGDGRPARDAKLAYPKGVAISMHNEIFIADGTNIRMVDKNGIIHTLIGDHYHKNHWKPIPCTGTFSLTQAPQSLAFGPNGDLYIAESDSQLVNRVRVLGSDGRISRFAGAELKCSCLELNCKCFDEDHFLASTSKLSTISSITVTPDGILHVCDQGNLRVRSVTASLPKPNDQHLYEIYSPETQQVYTFNRHGQHTSTRNILTGKVIYTFTYNVNTSFGKLNTVTDAEGNKVYILRDYSNHVKTIENTQGAKCQLEMSRMKLLQSFVTPDNFKTVFDYHGSTGLVRSKIDSSGRSVVYAYDEYGRLTEAITPSGQTIRLSYNLSTKGASVTVTRDGKDPVSLLIKGSDVTTRIGLSEERITQTSDGSLLLLSEDASSRDIETVANPVITDLSPVLGETFPVPAKLRISLSDDVNQRFEWRYYLRREGKARQKQIMQVGRKLKVNGDNLLAIEFDRQQYSETLYDRNQLALLTVRYDSLGHPLSWQPTQNVTSVTLEYDRFGRLVRWERGQLSEKYSFDIRGRLADVRYADGSGIMYKYDDGPISVPTEIILPSGSRYILQYDVSGSLQAVITPNGHKHEIATQTSIGFYKLLYLAPGVGHPYVLHYNDRGQVVAKFFPKNKGRVVYTYTDEGRLESILCGPERTDFYYHNSTALIKSITKNVPGLDFRVDYRHHGSLLKEERHRYNSRSGLDGAKFRYQYDPRLSSVEVEINGKSTITTKYRYNSESGTLEQVQQFLVHRPKLNSIFIQDEARQYSKTIGTDTYGRLVVLAITLWNKEIFSLSLQYDNRSRIKHAHTKIGKDHASHTTNYTYTVDGFLEEVSGAQSWRFIYDINGNMKSLWEGPRQISLRHDDGDRLIGYGDVELYLVDVRGFIVQRGEEKFKFNAMSQLVHAFELHQYEVQYVYDAQNRLIARKDHRGNITQFIYADLQRPTAITHMHYPKDSLTFVLIYDTLGHLIYMQQGNNKFYVACDHLGSPVAVFSSEGTIIKEIQRNPFGKVTYDSNPEFFLPVDFQGGLRDPVTQLIHFGGRVYDALGVQWLTPNWESMPTLLQKPYDIHLYRFHGNDPINPAQADGGHLNDLPAWMSALGYDMRRVLVAPQTRCPPDTRVGAPVPEAVPVISGLSCMADIVQAEFYRFSTVPKTAVKLDSSSFQRHINSRVSNLPSVLGDGILLSRGEAHRAAVHVVSESSPILRDVMVAIFNDTLIVDVHFSLHGQDSFFFVQPQLSKAEEDWVQLGRLGTMFNITKHVVESEGVGGPRGQVDIRMHSTSVVLNIRYGTSLQEERHRLMRHARRRAVDDAWTQELELVRNGHKGSNDWTKGEREELMATGMVARYFGTDVHDIEKYPELADDPSNVAFRKENSRKRRGKTRRTRLKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4F9</accession>
    <name>A0A9D4T4F9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4F9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050030"/>
    <dbReference type="OMA" id="QKSAHFS"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF8">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31924" checksum="D052E211312306B8" modified="2023-05-03" version="1">MAWIDSVLASLLHNVFLPLIVLSVCLRYALQRDYTARRLKFQAWLSNYMSYRETGAMLEAKEILFGKLESIVSRDWYLRNLGLIRILEIGAGSGSNLAFYPRNCHLVAVDSNPFTASYLRRKLARVPVLLEMFLVQNGGSLNNVKSCYVDAVVTTHVLCGVKDLDAVLKEIARVLAPGGKFFYVEHMRHDPGDWRRYVQMLIDPLWRRLFNGCSLTQELHDGIQKSAHFSSVSQCKVYSARSKFVGIFLNPVLVGIATKREFVRRRPMKLSNAFLTTRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4U8</accession>
    <name>A0A9D4T4U8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4U8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7970124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8409" checksum="E7350FB00A85271E" modified="2023-05-03" version="1">MSMQGAVQADITKRCCPGLRRSPGARYKRPRHAYPIPAVHKSPKHQQPGRCGGSTTPSGRPRTVRACRSGSISSTGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T509</accession>
    <name>A0A9D4T509_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_023967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T509"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051814"/>
    <dbReference type="OMA" id="WAIVVKI"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7970078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="72094" checksum="4FB16FD57FE87AB4" modified="2023-05-03" version="1">MLRSGAADDGSAEPLQPPARNGDLLRAYQEDADAAAAFEMPSAPLPPPPPLPLPPPMNEGTEPDSSLLQQHGNGSLPELRAPFAVPDDDSLGQPRKGSADSSQSSVKCRRRTKSMTCNMVSALYGKIAVVVTTVLVLTEVMDNSVPLLRFHGYLYAYLLGGSVVCLLGVYVSTMVDRCPALTGQPSRSGTDPELALRRGRVMTPCSDVSIYLRIGVVVFGLGTLLSCGLEIATIFTLTKPCTDPVNLAMPVLHALFTFLQMHFVFMNAQSVARSLGCMRHLVLVHLVVTNVAVWLKLLLWETASEWLRQSHVVQAGEGIWPPKGFNFTTHVIDDQGEHKAFFTSDCLWRPVDHLPMERMLTLQRCLHNTTVGAIWQKASPFLSPFIVQYSVVAAVVVYTIWDNYSYCTRGKNYNSRRSSPTADRIEAAVSSSTDRVVDCQGSSKGLFLGLLVLVAGIIVLILFFVLSNENMEIETLSAVTTLHCAVQGLSAMATAIGLCTVGGAYHKRGRTTQLNSILQGIGLLALYTYGVFGVVAGASKIFEGSEHLLLLMDGAFMVLFASLQSLFVQRLAMRCLPKKNNKSGLQVVTFLMFSNLVLWLLETFTNQNHISSQQQLAMYGAVSWGIISRVALPLVIFYRFHSCVFLLEAWQLPITLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6T8</accession>
    <name>A0A9D4T6T8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidative stress-responsive serine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Oxidative stress-responsive protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6T8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036081"/>
    <dbReference type="OMA" id="TSARHPM"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008494">
        <property type="entry name" value="DUF776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383:SF2">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7982324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="16686" checksum="221123D4505A6DCA" modified="2023-05-03" version="1">MAAAQGTGSAEPEDTSKKRVRSAPSVLDDLDTAIKKLKVSAKKQDGQGAPDLPRKPRKSHLLGPSRRLRSRRPSKSTSETSVTPNGPAGASAEQGAESTCPGSFRVNSVKESSSAPDLTCEPPIEDDTTVNELAAYFENLVHIPRKMSAMAEMMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7A3</accession>
    <name>A0A9D4T7A3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7A3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028100"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20064" checksum="0273CD272A4CC166" modified="2023-05-03" version="1">MGSLSPVVQLAMELVDSDSKDGENDELVTKVALKLARQSRHRVPPYCEDVVSRYFDFEFKRLFRLSRDTLDELVARFEASSFYPSALGGRPQISAEKTCLIALAYLGHQCCMYSLADRFNIAESSVQTCVDRILAFLNAISEEAIAWPNDEEKERDKAGFLARSSGKGVRTAQHHRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7I6</accession>
    <name>A0A9D4T7I6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_011830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051463"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="66"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7976318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="303" mass="33507" checksum="0AC2B003EE206697" modified="2023-05-03" version="1">MCLEILVHDFDCFVLNYGRVVIVAAVSQGVTEVKTMQIEVTVPNEYPPRFEHPVYRAEVHQTRTRPGYRVLQVRAQDPDPVPYNAEVYYRLEAGPESTRALKYLALDGITGEVTLNRTLSDVADAMIAFTVVAEDGGSPVKEDRARVEILVKTISDCLMNVCKHGSCEAREALPGLSLPVRPGLLRRRLRALRPVLREPVQDVRHLRQHQPRRVPLATASPVSPVATVPTSTRACSSLPACLHGGVCESNSSHTSPALCVDGYYGKTCHQYDPCFSSPCMHGARCLNESDEKFKLPMSSGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7S6</accession>
    <name>A0A9D4T7S6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7S6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055615"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="307" mass="33323" checksum="EB68FD6FA9FF9BE5" modified="2023-05-03" version="1">MGNNSVEIVKFNKCARDLYDRVQSNITDHLRIRDVGELGPALRNLSSLHRLNGNIVKNLEALQNSFQRLRLPPSGGASGIEPLQRTLQSASEAFRNMSKSVTSGAALQTVVHNFNRTLQTFNSIATAGVNAMTPTANQLVHRFQEDLKNIQNVTRSLPRTDVARLTEQTRGNLTLLVRNLTGALPVLMRRMATQGAESTRLLREFVTALSHNLRNASLALSNSGNASGNSTGSTLPTASHDLLQAYDGFQLAVNNGMLAMSDLVRGSLKLVNPANWHVGRVGLGAGDGQTPHAGINKFIGQLFRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7V1</accession>
    <name>A0A9D4T7V1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7V1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035028"/>
    <dbReference type="OrthoDB" id="3535323at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7976764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14887" checksum="95DB890121865716" modified="2023-05-03" version="1">MLCTKASPTLVKEEVDEEGIPQDGAGMPGKAGASGSCQGTRVVACCSKFVCKSCQATFEEREQFLSHMQKQHAAVECFLCGRRFGRQQDLVRHTRMKHDAADCYFCPLCPATFSLKRALLKHTRRHEDDAYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T882</accession>
    <name>A0A9D4T882_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_023131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T882"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026954"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="279"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7977020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="431" mass="49071" checksum="AF36856F97BC43CE" modified="2023-05-03" version="1">MVLTNKSNVDRVLRDIGEGEVRRMFPAPPNDGGVETRARTAAVPTATTQLLSTMGLFLRVQRSARSVLLLSKRRALLRFCKFNPGAFLISLFLVSLWLSALRCPTWLSGDHIVYSEADIERNASECPWTPRQGHQLSWLSIDSRIKCAANRGGAVVVQRSVNRTLLKELESKLLPGGRWSPPFCRSPHFVAVVVPYRDRSEHLDLFLQHMHPFLQRQQLQYGVFVVEQSERHAFNRAKLFNIGFAEALARDSYCCFVFHDVDLLPIDARNVYRCERFPRHLSSAIDVFRFVLPYPDLFGGAVAVRADQFRELNGFSNEFFGWGGEDDDLQRRIRARGLSVIRWPSSVSRYTMLAHTKAKPSLQRQELLRNAESRYEMDGLNNLRYQVLALEEKPLYTRILVDVDPPAQPEGIPGLVDMQRAKGRHALLGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8J3</accession>
    <name>A0A9D4T8J3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8J3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054708"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="1">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14389" checksum="8472AD6A1620DC74" modified="2023-05-03" version="1">MACRYRASTHFRPETSPTERAQRLTALATNIGARVREAVEQQQRDAGPLAFWLANASELLHFLRQDRHLSAYTLDAQDLLTEALQLAFRQLVSAQRRELAQALPRAFLSPDTATDAPIGECPFAGENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T916</accession>
    <name>A0A9D4T916_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_009027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T916"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055466"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="238" mass="26956" checksum="002503D76070CB11" modified="2023-05-03" version="1">MQYPSPEWDTVTPEAKNLINSMLTVNPAKRITAAEALKHPWICQRERVASTLHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSIMTKKGEGSQVKESTDSSTTIEDDDVKARKQEIVKLTEQLIESINSGDYETYTKLCDPHLTAFEPEALGAGKSYKSQNTTIINPTVHLLGDDAACIAYIRLMQYIDRAGIPRTRQTEETRVWHRKDTKWQNIHFHRSGNSAGMHPDPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9D7</accession>
    <name>A0A9D4T9D7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9D7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025969"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000058">
        <property type="term" value="P:regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16077" checksum="F89A074F3451312B" modified="2023-05-03" version="1">MTASIVRLATVMAMGFSESVARLALRSVGGDVDLAVQHIITRQDEKKAQQEKELEERNLKLRKRSLGKTCNGEWVSVEKYDALKAMGFPANNARHALQQANNDINVALQALCECCFTWETVDHALALVPTQLCMATGSSCLCPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9U7</accession>
    <name>A0A9D4T9U7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9U7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="81" mass="9235" checksum="A3D0B8BB5349D70D" modified="2023-05-03" version="1">MAQSCKRPGEASGPSHAPPIQPDQRADVRNIDENNPPATDDDASTIVKLDEKVDDWSDMDDDNFKMISHRKNRTFRLIYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAH9</accession>
    <name>A0A9D4TAH9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAH9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13745" checksum="C3D54209254216E3" modified="2023-05-03" version="1">MAARGTPRRRDDDEVGRGLAGSTLPDVTRGPGCVYGRTMFVEEATSPVQPHASIRANEPCRATHEQRRAAVRRLSRSSHSKSHEFRRQASRRRDAAGRQSHLSQGEGHRRRQEEEISAEGDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBD0</accession>
    <name>A0A9D4TBD0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBD0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028224"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="297" mass="32087" checksum="CB562A3C83CC5239" modified="2023-05-03" version="1">MSYGSPCRCTCGALGNARSTSRPTPRQQRYTRTKISRQASEPGEQLPRINASSPLGCRSLAEGVDGSDVDAFIELLSSRLYHDSFTDDGSDHQPQQQLMQTTSIGSSPTSVDVISNSTSSSSGASALTARSTSNDLTISEQLVVQLFMDEVDSKEKEMAAAIAAKAAREPEEGHGDVLATMTEDDSQWPTYSSSAAGRRGARRIGCEALAAPSTMAFLLLAAVLVFNVLLAVVYYEERTWLCVATAGLMHAPSLLFFVARFYTVTVLASVKETFMRALVLIWYSVTLPLLHLMPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCH9</accession>
    <name>A0A9D4TCH9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001063">
        <property type="protein sequence ID" value="KAH7985178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCH9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056934"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="180" mass="19600" checksum="3825A2B02A084049" modified="2023-05-03" version="1">MQSSDISILTPDYMALLQGLCVNTEPSLNDVTTIFKEFSRSLDARKPKLSPKPSTSSSTSSGASKKRGGKSAARASAASDDADEDGSGILHSDVGFERSLHVGADEKPCWLMSGRGAVEPHPHQELHELREYMWGELVLQGYEWPEQKPGQQDMLRASLLMHGHVVSDGVCESLTMARDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE69</accession>
    <name>A0A9D4TE69_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000135">
        <property type="protein sequence ID" value="KAH7987089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE69"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046681"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7987089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="206" mass="22747" checksum="759E43098403860A" modified="2023-05-03" version="1">MDAANVGNNLVALNSPDFSQSTQRIQHTLGLFGYGTLRDEHQLEVASSSAWNRICQPVPNAPKMSTAVDLIANVSHPKVNFTLTISLRLDIFRQVSLAALNSRSLRRIVSTGHDAVFFSTQCEQQLFARDPTGLSILDIGNGSCAFAWGPSQVFEVITFETPKTVRSKDVECVQKELAKGFPRFDIECVMTDDYRENCLKDVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQC2</accession>
    <name>A0A9D4YQC2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQC2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030896"/>
    <dbReference type="OMA" id="HMEQRDD"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="282" mass="31557" checksum="FEADF942F9CD3500" modified="2023-05-03" version="1">MHQRHPRLVRDIYWDEAEPQLPYTKSSVNLRTQPHLGSAMTLDVDPEESEFVPMETILEEDHDEHKYSSPPTSPPNAADVPQVPGPLGSHFYHVPLHLQPSECAPPSTISNHLLDSPLITTRNTSDNTTQTGLRILSTGSRLLNLIIGSSNDNLPQSPKIKDHPLVPHFVSRPQLSRRTARTVSLCEGLDHRSHEFTVEERRSLLRGDDRPTIKESVPTSVIVDLAAPPTTIEEAKQTDESQHDKRMEEQPEPSPYEPNSSTESLVENSQCSTDSYTQLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQW7</accession>
    <name>A0A9D4YQW7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF-related serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SNF1-related kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HPB52_023515</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
            <tissue evidence="23">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQW7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051409"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000166">
        <property type="entry name" value="SNF-related serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="543"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="679"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7984686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="750" mass="81404" checksum="666ACBC2E3F5383B" modified="2023-05-03" version="1">MNRPKHQQQYDPKIAGLYDLGDTLGRGHFAVVKLARHVFTGEQVAVKVIDKTKLDDVSRAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLEYGDGGDMYDYIMKHDRGVSEQAARKYFRQIVHAIWYCHKLHVVHRDLKPENVVFFEKLEMVKLTDFGFSNKFCPGQKLETSCGSLAYSAPEILLGDSYDAPKVDVWSLGVILYMLVCGHAPFQEANDSETLTMIMDCKYTIPPHVSDDCKRQGLLLMIARMLIRDPDKRASLEEIAADPWLATGDAPQPADHLPLIHREHLSEEDHSHIIQKMVNGCIASKDEILEALDRNEYNYMTATYYLLAERKLRAQRQEKAQQLNRTSRADLSPVAVTPGVSSAAPSPAQERPNVAQVLASPGGLPSIALDPSAGHPLASLLSVSSGPLEDDSSLAVPRSSLPLGRKCSIVREEDDLSSLAPSHSPPIRGAVFSEENESAESDERAVRPVLSLPTAPSAPSPPIPDGAPQRQSPTVRLRCIPGRRLHAVKSSPQLLGGAGDIRVRSGVGKLRVHVAGRNRTTSCSSSDDEEGDKRRHPPTAKGDTPLQGSPSGSVLPSPHAHDEGYSADSTDSLDILPDPAPRLTNSVSCGDLTVEESPASKSDEGASSSAVQCADIVLVEEMASADAPRISNSFSLAAGLSCLGRKSSRDEMQSSRSRLGSSLAKLVPNGSRNSASNNAGAVALKPQLDINQNGFRKGRSKSQSGVVDVKLASKCCTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRW2</accession>
    <name>A0A9D4YRW2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000196">
        <property type="protein sequence ID" value="KAH7987000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRW2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036912"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7987000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="616" mass="67727" checksum="238C6DE1D6BF5AD0" modified="2023-05-03" version="1">MRNAGRTVGGTLRSAGNSALPQGLSALQQRSRAGQESIFAPLKKDSSRTAGTPGAARTRTNRPMSTTRSDPVNKENMLSRGSSGTRKCGSIKSSSSKDSLDSNGQTKEHKKPHSGLGQPTVGTQTSESAGKASPTTILQLEREKSLLEQQVSELVRNAESKKAEIATLRMEIKHLKQESSGGSRQLEALQLENCSLREKLVQLGVEPAEASGKQDPLQRSASAGSLDGAREQVAPQSLRPNESPDNNRHPNEHPAQAQRRQPRGDISSVRWPYALAAHSSLPSDRRPSSRTMSRRPGIEPQYQKQRHPWPLATRLHKPRLPESKRQKKLFTETRTTYEASAKSVDGALSDDACPSGSRLEWDKASTSSLSEMSVACLQDRIMQMEETHYSTNEELQATLQELTDLQDQLTDLQLENERCCDEKALLLESLCSQTEKLEECRSHNDHLRALLFGHASPPPQASSSSSTPAVEAQLSREQHYVELLKKAHEEQTVLRGQVDQLQASLEVASREAQDHQRDLQGLAHRVSLLQAALEAAQAASASAGPHGEGDNAAPILDQGLKIQSKMHDSIEDAKTALRLYRKYQQLEREGRVTESLKEMYEAGRKSSWKVPGADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-24" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C9W1C0</accession>
    <name>C9W1C0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_000308</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2010" name="BMC Genomics" volume="11" first="450" last="450">
            <title>An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus.</title>
            <authorList>
                <person name="Anatriello E."/>
                <person name="Ribeiro J.M."/>
                <person name="de Miranda-Santos I.K."/>
                <person name="Brandao L.G."/>
                <person name="Anderson J.M."/>
                <person name="Valenzuela J.G."/>
                <person name="Maruyama S.R."/>
                <person name="Silva J.S."/>
                <person name="Ferreira B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20650005"/>
            <dbReference type="DOI" id="10.1186/1471-2164-11-450"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="5">Salivary glands</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="Ticks Tick Borne Dis." volume="4" first="469" last="477">
            <title>Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine.</title>
            <authorList>
                <person name="Oliveira C.J."/>
                <person name="Anatriello E."/>
                <person name="de Miranda-Santos I.K."/>
                <person name="Francischetti I.M."/>
                <person name="Sa-Nunes A."/>
                <person name="Ferreira B.R."/>
                <person name="Ribeiro J.M."/>
            </authorList>
            <dbReference type="PubMed" id="24029695"/>
            <dbReference type="DOI" id="10.1016/j.ttbdis.2013.05.001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="5">Salivary glands</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="EZ406068">
        <property type="protein sequence ID" value="ACX53867.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C9W1C0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032617"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACX53867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7938773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12517" checksum="271B89784D3F4BD6" modified="2009-11-24" version="1">MVNVPKQRRTFCKGKCKKHTLHKVTQYKKGKDSLYAQGKRRYDRKQRGYGGQTKPIFRKKAKTTKKIVLRMECTECKNRKQLPIKRCKHFEIGGDKKRKGQMIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB86</accession>
    <name>A0A9D4PB86_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB86"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052170"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="297" mass="32736" checksum="BB014468A16FC384" modified="2023-05-03" version="1">MASGSWLSGSGESSLLHAYLESSGGASATTGLSIHSNGNRKACSHSDTVHKVCSGESTRAADMVRTFAGSLCALCASVLSKTRSYFKDPWGLQQAASSNTVTVEDHQLQRRSSSHCQRRRHPQQQQQRRRDAEVGAAKVPTCCDYSVRRKWCWTAWMPALCASVVGALCYVNSLDGDFVHDDMVAVVGNLDVNGDSRRHASSSSSSLWINDFWGRPMADPRRHKSYRPLTVLTGQSRQPGGLAERFPFHTSDGRGKIPGKCEARVLFFSHQLSAWHRAWEMRKATEDFVECGAQILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD49</accession>
    <name>A0A9D4PD49_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD49"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="179"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7935395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="433" mass="48650" checksum="D5CDEEAD24123F8F" modified="2023-05-03" version="1">MDLLWELDAALEAFVVQPMQAMLGALAIPGPPAFPIEEVDVMPQQPPAIAPAYQQAIGDSQLSASTMRRRRRRNDATTKSQRGVEKTPPTWDCVQLMPVEKNIYREHATTAQRPEADVNAYRLENDIDISGRGIPKPMLSVEEANLPACLTEWMRARNRSLTHIEAQCWPVALSGRDLKAVAYLVPAALHVLNQPPLQSSDGPIALVLTATREMARQVHQVACDIQECTKVGVALLSCHAPKDFQLEDLKKRPQICIATPARLLTFLKEGLLNLCRCTYVVLDGVDLMVDMMIEDQIHAVVEWIRPDHQTQVWLNSRTQKAHVLCEYLLEDYVLVSIAAQMDAADDVRFVVNYDCPKCSEAYARRLVHASHSRTQSGAVYTLFAHQERRHAADLVSILRDAKQPIPAELEELVKEASRDRISAADRRRKRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR5</accession>
    <name>A0A9D4PDR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="691"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7936142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="796" mass="88276" checksum="26103C7284858062" modified="2023-05-03" version="1">MEEPPVAGSEMAFSDSKPVEASEAIVKSSEGEDASENLTAALDVVDKAWTAIENGHATEPATALLDEKQLEEAVVSSEADRSLSFTNGECCERLEIVETSSPEEGQRVMESECCLAEAQDAVAPNDNGMTAAASDFAAGEGTPVECGSPCLDNGTTDGDSAVPSDIISHAVEDAGSPSTNDDGEPAQLAEEEVDVRGTPLSENDAAESSATSECDTKTDDGLHNINLDLGNIRQRFESPQESVPSVADRSALGRSESLLQRLEKYQSVAAGERNGDAHSPTESEDEDSSVVRETKTKEKVVYEGLSSLKSQWESGTVNSHQERTEETKEELAKLRKKMCLGRSESMRQVYQKAVEDANRIQAGRAEQISVEGQEARATSIKEKFEAGVVTQETEAEKIERLQREKQEELSVFNETGIAHEAKNIFKQLDAEVARQSGAPSASLARSPSNRWNVARPQQNAVSPGDVVRSSDPVHDVEVATTEVSERFKFFENFKDDSNKQRKRFEMTPPRESGKEPSPEFQPPRDPNVVRAADPAEEVIVTDTARRMRERFRELEVNASREEPPQGPKPLKRITPPREYTRDNAHEPSPEVQRDPDIVQCSYRVEDDIVVEADRAKSMRARFENWDAEREARESRRNGENADEECLPMADTAKTLRAKFEAIRDESERQEAHRPKPKVNRFVEFPGTPNSEACAICNKKLYPMERMEVSGLRMHKNCFRCSHCSCHLRLESYTISGGKLYCGPHFKQFFIAKGNYDEGFGREKWSRSASPASRESNEEYTNGDRDHMGILDQPVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE41</accession>
    <name>A0A9D4PE41_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045813"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15393" checksum="DDDFA6D1CD5E6B0A" modified="2023-05-03" version="1">MGNGIGPEPPENSISVDSDEISAIQPPDELWKASSGTVVLHNTGGSLGLKLRWQHGIWTISDVEPGSAAARHGELRVGDIVLSINDQMLSEKTQGEVAAILALVQDLSVVLEVEGEPAEPPPPSPSVEKVKMRKVNGFKEEVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE83</accession>
    <name>A0A9D4PE83_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_019851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE83"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051858"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="450"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7936186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="646" mass="74373" checksum="69DC84097173EC2B" modified="2023-05-03" version="1">MAAAWSKLLEQRRPAVVAGTVALIYAWSYFRFLRKQKRSRELAAAALVFDKKDAKKEKAHVDREFFRQLGSLLKVVIPGVFTPELCDIWLIRNGTIIERAIISRNVSLFKDTLQAFIFTMPMLSMVNNLLKYGLSELRLRFRSRLHHALYKEYLSGITYYRMSNLDNRIANPDQLLTQARFTLTRIHTADYLRHTHGDVEKFCGCLTDLYSNLSKPLLDIVLYVRWLSVAIGQEAPGAMLLYLLFAGVILTRMRRPVGRMTIEEQKLEGELRYVNSRLITNSEEIAFYQGNDRERITLDNSFRRLVQHLRDFLEYRFTLGIVDDIVAKYLATVVGYLLISRPFMAGQRMQLDHNQRLEEYYKSGRMLVKLAESVGRVVLAGREMTRLAGFTARVSQLRHVLHDLARGHYVRSMLAVEPAVAEEAGDTSKPRRRMELVPGAGRIITRDNIIRFQNVPLVTPNGDVLVDDLSIEVRSGVNVLVCGPNGCGKSSLFRILGELWPLFGGTLVKPAKEKLFYIPQRPYMTLGTLRDQVIYPDSHLDMLRRGVTDEQLARFLHLVQLDYVLERERGWDTIQDWMDILSGGEKQRIAMARLFYRQPQFAILDECTSAVSVDVEGSMYQYCRQAGITLFTVSHRKSLWKYHETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFE7</accession>
    <name>A0A9D4PFE7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052945"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7939482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32898" checksum="CFEACDCBD8431530" modified="2023-05-03" version="1">MADNEQKAMQLVADAEKKIKSAQGFLGSLFGSSSKLEEACEMYARAANMFKMAKKWSAAGSAFCEAANLHLKNGSRHDAATCFVDAGTCYKKSDPQEAVNCHLKAIEIYTDMGRFTIAAKHHMTIAEIYESEIVDIEKAMSHYEQAADYFKGEESTSSANKCMLNVARYAAQLEQYEKAVDIYEQVAASSLDNQLLKYSAKEYLFRAALCHLCVDILNAQHALAKYEEMCPSFIDSREYKLVKALISKLEDQDVEGFTDTVKEYDSISRLDQWYTVILLRIKKTLQETPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGF0</accession>
    <name>A0A9D4PGF0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_022084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGF0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051685"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7940169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="867" mass="93443" checksum="5D9C7A0069DDAE1E" modified="2023-05-03" version="1">MSSEECDTAAPSREKSRLLKSTLRALRSSTTDVEKLAALLVLTKVVDASTVQLESKRKLLDAIGVSFIVRMLKSDTDSFRALGADITSAFAVEPTLCERLRPALDALTGSLAELGVAAGVECASRLVLHEPGCRAFVESGMLKALVDLSPAELGSLLTALAACLQSTKSRGLADDCEYEAALLSSARTCVGQSLAARLGAEARRGLFALLASLVERRGVRSLGAPTVALAAVELEMQLCSRGQQPDAELVAHCCLLLEVAVDDAVASGRLPPAAADRVPGALLAFLDDAFQSPSWGPGEAAVLPACRLLCRWLADDSTTMRPEVGKVLPPLLDLVASNESMLPLLIPALCHLTADDRLRPIVLRSPVLARLFDYLTDLGAPAGGANTEQQKLGAPCAFAGELPQGAEGAGKDELKTQFTTREGTYKVLSLSEYSRPNRVGYSSSQSNSPVKVSFVSLSDAAGTEDRICFNVGRELYVYMYRGVKKAADLSKPVDKRVYKGTYPTCHDFHPSATPDGGLLLLVGFSAGQVQLIDPVKKELSRLYNDERFIDKTRVTCLKWLPNSNSLFLVSHASGQLYVYKEDLPCGSTPPHYQLFKQGDGFSVFTCKTKSTRNPLYRWVVGDGALHEFAFSPCARYLATASQDGFLRIFCYDTMDLVGLVRSYFGGLLCVCWSPDGKYVVAGGEDDLVTVWSFQDKRVVARGQGHRSWVQGVAFDACLEGGHASGDCPAADTSYRFGSVGQDTQLCLWDLTEDVLKQPRAPRASLLLTGSNSPNAANCSQAPQQQARQQQQQTRTNNVSTVGPHQRLVGSPACPRLDEVPMLEPHICKKVAPERLTALVFREDCLVTACQEGYVCTWARPGRASTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGR3</accession>
    <name>A0A9D4PGR3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGR3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15848" checksum="D586685ED4D87049" modified="2023-05-03" version="1">MWRCGAPSWAPFLRFSCSSRPTLATVFAYGVGTVPYHCVLHGLVKVPKPQDVVARRAASIGYGELRCLRLLQPHKEQPQRRELSTDRVLCRAESYIRTVCEDNEAVVKAESSMAEQSSSLRLGRIAAATHYPRLRGAFHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGV4</accession>
    <name>A0A9D4PGV4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGV4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029523"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056488"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="395" mass="42813" checksum="742AE61C7B6180A8" modified="2023-05-03" version="1">MVITMRVKIVSGVVYSPYPDLEDLRDVSTYAFLKRRLQNYGDKTALIHGQDKITYSELLEKLKIMASGFRSHGIGTGDRVLVHVENGVDSFVAACSIPLTGATLVTSDVTFNEAAFWDAVAIFWGTAAANLSSTTFRAADPKAPATSLASRLSDQLLVNVVHGTPTKLLEIVHEAKRVGQSFPRVKKFTTLGTPITEMTRSAIVAACSPSELRSCYGMTEVSGYLAAPPCGEITAGDVGFPAPGTRMKVVDPISGAVLSHDQKGEVLFHTPHIMDGYYKSPEETASFTTDDGWIRTGDLGYYNEDGRLFILGRVKAAVSANNIWAGLPQIEECLAFHPSVAEAAVMPNPEFPAAIIVTRKDEEPSERLAEEIKTFVKESNETGLSGPLFVIDHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGV8</accession>
    <name>A0A9D4PGV8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGV8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026591"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="9712" checksum="74A4E310B244BB7B" modified="2023-05-03" version="1">MVRTISNAPVECGTYPLTFEQVKNVAAEKGSNPPDYDQLTASCQTTAKQILSDLGVTVGTQSAMESALTLVLSLGGEEAAEKLQNAVKVITAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIT3</accession>
    <name>A0A9D4PIT3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIT3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057617"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="25326" checksum="302AAFCAA93FB90B" modified="2023-05-03" version="1">MDQPQYTRLFDIRNAWSFHPSWRQEATSRSLARIMHDIYELHLAKPQCVLFEPEEVDVSKNTPYANAMLYFLLKIPKNYPQQPPRVSSLPSVSTPLCIHPRVSADGLVRMDITGTGAAVASWSPETDSLRSVANELRVLLRSMNQGDFVLPDEDWFDAVVKHETLRLGVCGVVDECMKQDNAVPTNLRKQLLANFLYRGVHYLQAAFELAQLNGEILWNVIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKH5</accession>
    <name>A0A9D4PKH5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanine nucleotide-binding protein G(O) subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_013755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKH5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052394"/>
    <dbReference type="OMA" id="DDIVFRM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7943952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41301" checksum="0883AFB744CD4E16" modified="2023-05-03" version="1">MGGCLSLDDEERKARLRSAQIDRQIAELARQECNVIKILLLGAGESGKSTIVKQMKIIHSEGFSDEELRSFRPTVLDNLLGSMKYVLTGMGILRINLENPKNKMYAQTVLSCQCCFDESMTMLPFVASALKNLWNDKGVRLAVARGFEYELNDSALYLFENMDRVCSEKYMPTPRDVLRARVRTNGIIETHFKIDDIVFRMFDVGGQRSERRKWIQCFDDVKAVLYVVALSGYDMTLQEDPTVNRLHESLKLFSSICNNMFFTDTSMILFLNKLDLFREKILYSDRHLRYYMPDYKGADYDVDSGALFIQHKFQSRNRDPNKVVYPHFTTATDTSNVQVVFQVAMDTVLRGNLRTATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL74</accession>
    <name>A0A9D4PL74_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_016412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL74"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055351"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7944135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="211" mass="24754" checksum="BBC6138AA76B521A" modified="2023-05-03" version="1">MRGKPNVVMQVWHHRRVVVEWLQDGSGEKAFTETILNMDAKNYHAWQHRQWALAEFGLWDRELDFTTQLLSNDVRNNSAWNQRFFVISQTVGFTEEVVERECAYAMECIRKAPHNESPWNYLRGVIDAAGGAERPEVQDFCKSLYEGNCRVAYLLAFMVDSLASRLENEPKLLELALKLCRVLAQEQDVIRREYWNFMARDLEAQHRRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLG3</accession>
    <name>A0A9D4PLG3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_007507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054724"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.210:FF:000002">
        <property type="entry name" value="Blast:Glutaminase kidney isoform, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="9">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7947076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="539" mass="61280" checksum="8FDBD9FD304B3901" modified="2023-05-03" version="1">MIRRLGRVVGYHRRAPKVCPTTTRLLQPQATKQQPARFFNRYASLETTSHANRVFVPAEEFHRDKEKPFDKCENGPVNVEDLLFDMFKDADDTVCVGKFLNALFTTGLWKNDPRLKEMMQNLRNVHKEKSPVRSLESLALNRETFAQVIRENIVLITRALRHQFVIPDFQDFIRYVEDFYWKCKVNTGGKVASYIPQLAKYNPDYWGVSICTVDGQRFSIGDTEIPFTIQSSGKPINYAIALTELGSDAVHQYVGQEPSGRMFNELVLDYNKKPHNPMVNAGAIVVASLLLYLIEPEMRTSEKFDWMLQYYKAVSGGEYLGFNNAIFLSEREAADRNYAIGFYMKENKCFPERVNLKETMDFYFQLCSLEVNCQSVSVMASTLANGGICPVTGHQIMNGVSCRDVLSLMHSCGMYDYSGQYAFKVGLPAKSGVSGCTMVVVPNVMGICLWSPPLDVYGNSVRGVQFCEELTRVFSFHHYDNLRHMTQKKDPRRQKYETKGLKVVNLLFSAASGDVTAMRRQVLSNHSLCYVLTSEVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMD6</accession>
    <name>A0A9D4PMD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046754"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="496" mass="54852" checksum="2015C7E2C598C5AC" modified="2023-05-03" version="1">MAPASPHLAMQAIVDAMHSAPGRLLCRMRAPTACRFSCSVQSYYHRPGRERLFSCTVGDVIERTAEVRGDNLAIVSSHQSIRKTYAEYKKDIDHFAAALISLKLGIGSRIGIIAPNMYEWAVVMFAAAKAGLVLVNVNTTYQIHELEHCLNHTDCKAVILSEQFSKQDYYALLLKLAPELASSPFGDLKSARLPSLKYVITVGETVKPGTVRFADLMESVTNEHLRALRCTSSKLQMDDAVNLQFTSGTTGKPKAAQLSHFNVVNNAYLVGRRLELHKQEEVICLNVPLIHCFGCIAGTISAAIFGSTAVMPAPSFSAAAALKCITEEKCTFVYGTPTMYIDMLHHVEDGCYDVSSIRTAVMSGAPCPNHLTKDIMEKLNAKRIHVLYGTTETSPMIAANDPNEPVDQWITSVGRPLDHVEVKIVDDKNRIVPANQRGELCVRGYAVFMGYFKEDKKTKEAIRNGWYHTGSEDEIAIPAQKRFRQRGARYHVPMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN45</accession>
    <name>A0A9D4PN45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055128"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="721" mass="77132" checksum="2AF7B502A5F0A9F9" modified="2023-05-03" version="1">MADDLPPGFPPCYSLSGDLNHSKTYELLMKEAANLVREQATQEPWRLSPPRISPVRTNRTRARQLKDAASFLRKDTMPVSRTRTRKASRTPAAPKNAPQPGKARKGSSNREECCTQHDKITFAPSQQESETNSRGSPPPQTPPSWKHTAPPSCYPADPPADSSPEETRLAGSPLPSFPAAADVTRSPQKKAASSLGTAKTAAATLVPIPATTDTMESTVADEQVIPPDAAAKQASENAGKGKPPSQHAAGGGSIPSCVMGTLAVSDEDDAFPSLPSTGAPPGTPLCAPLVPAPPRGPPQAKAKPNGPPQPPATNTAEPRPSPKRALPANDSASMDASDSNEYPADPDDGSWFTATRRRKPKTTANSAPAPEPAKNQETPRPPPLPVDDLKVVFRPQGGLRLSDWAQHLVARAISIAAGLPGETVNKLLFRINAERNIAIASTPDETTATKLQAVTVINLGTQRYETHAYIAAPDNSCKGVIMGPEKNTSPTELLDNIYTPDAEILHARMMGSTNTALITFADLQVPRYVYYYRAEYRCYIHRPRKQVCTICLALGHRADVCPTPSERRCHACGVETPAPQHSCTTRCFHCKGDHPATHPQCPARERKPPNKQYVKKALEAKALTQPPTSPPKGHRPRSRTRRSRSKSRGKSQDKSTAPLKNTPGTTSKPRTPTPGPIQKKNRSGSAEGSESPPAKKPAPAGQTPPAKDTVLKEQDGPPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNK6</accession>
    <name>A0A9D4PNK6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNK6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040037"/>
    <dbReference type="OMA" id="ARIDSWT"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="256" mass="29572" checksum="97C1FDEE67A9568E" modified="2023-05-03" version="1">MAYVLAYLKELYDYVWSFRDTRIDAWNSNITTGSFVIPLIISYVYVAKVGGPLWMKDRKPYDIKRGILAYNALTALANAYFLYRMLPLTLFGGGYSFLRQGIDTDRERDMAVISLNWWYFLLRVADFTDTMFFVARKEYTHVTQLHVSHHALVVLNGWIWLNFGSDGHAVFGPRVQKYIWWKKYLTTIQIIQLVVICVHSSLAIFFDCGYPKGLCYLAMAQIVLFIVLFTNFYLKTYRAGGRSGPPPAAKSKEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPV8</accession>
    <name>A0A9D4PPV8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPV8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7950820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34996" checksum="48701A51A031E5E7" modified="2023-05-03" version="1">MKLNGSKLVYLRVAEIALAIFFALNATVAEARTVSFCGTHDYGRVCKDVYRRYNEDHILCRQRYSSCQPVRSGIDDADKDIILTAHNRYRSEIATGNHSRLPCASNMLEMLAWATTWKVGCGYTLYSSRSAYDFEKRYTCAYGPGGNVRGEEVYKVGPACTDCPEGTCCGESCQQYNITPSYSGLCTTGHAESVLEAGQSAEMTFEQPIKSSHGRLCIEVEYNKGPNVAGTLDRGLFELLVTPVVRPQRQRTINLSGGAINTMRMRITLHYNFDVKIGFSFIVPRGSPAQYVNIHKVLIYEKACPERYRHALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ12</accession>
    <name>A0A9D4PQ12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">(3R)-3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="19">1.1.1.239</ecNumber>
            <ecNumber evidence="4">1.1.1.n12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">17-beta-hydroxysteroid dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Estradiol 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Testosterone 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HPB52_004239</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Rsan-2018</strain>
            <tissue evidence="27">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:24614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:32712"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.239"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14930"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.239" evidence="19"/>
    <dbReference type="EC" id="1.1.1.n12" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033731"/>
    <dbReference type="OMA" id="YKCSVQN"/>
    <dbReference type="OrthoDB" id="8123394at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047035">
        <property type="term" value="F:testosterone dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000231">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="26">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH7950999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="258" mass="26577" checksum="793E7FE2F2CEAE39" modified="2023-05-03" version="1">MAAADAAFTGRLALVTGGAGGIGQAVCRTLAAEGCIVVVADRQFDAAKKVAESLPGNAKHLAFYVDVGDSSSVERLFGDIRKTFSEPLSIVVNAAGILRKCSLVDCTDDTFDDVIRVNLKGTFLVNRAASRDMLRSGIPLPKGGAVIVNISSIEAKNGSWSSAAYSASKAGIVALTKSAATELAGHGIRCNAVLPGWTDTPMAEGGDDAVKAQALALMPIKRPAEPREIAEAIKFLCSPTASSYVNGAALEVTGGFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ23</accession>
    <name>A0A9D4PQ23_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ23"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028011"/>
    <dbReference type="OMA" id="DNRYMHL"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11147" checksum="4E1F8D295DF58A24" modified="2023-05-03" version="1">MASPRVGGLSQELKPADATVQEICEKVRSDVENKLGQTFAEFTPVNYKTQVVNGTNYFIKVRVGSDQYVHVRAHKSFQGDVTFAAVQENKSLDDEVEHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQG5</accession>
    <name>A0A9D4PQG5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_016841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQG5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051269"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7947922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16372" checksum="B38C8923A97960A6" modified="2023-05-03" version="1">MGYLKYIEVENFKSYRGLQLIGPLKPFTAIIGPNGSGKSNFMDAISFVLGEKKNCLRVKKLSDLIHGAPIGQPVSNRAHVTAVYCNEDGTETHFTRWWHTRHPSSALTMRDDVETIAMTNPKERTVLFEEISHLARAKSEIRAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQQ9</accession>
    <name>A0A9D4PQQ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQQ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046727"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="34111" checksum="92F63D05C41879ED" modified="2023-05-03" version="1">MNCTAPFCGRCGTYGHDGKGCSLPCRRCGDPHATVACTIRRSYSEAASKDFPPLQPETPASDKGEVPPTPVPGPAQDQNTQDATPHPTPAAAPVSPDPASASTADHQVCVSRPPVITIERHAGTSLHSESPGRTDADDSVTSDTSHAASSSSANPPTIEESPSTDDGTVHIEDSDSSSSPGRGRSNWNAKELERLVQQLSLTDVYDRTYGGRHVYTWRRATSSSRLDRAYVSPGLMAFVCNVEVVSLPPTPVYISDHRPVALTLHLPAGTPAVQRPWRLDCRRQLGAVDVRHVHALRSSGMHAGRSSVRAARLLTRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR31</accession>
    <name>A0A9D4PR31_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR31"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="13969" checksum="E5D8327FD9D62561" modified="2023-05-03" version="1">MTITGDSRLVIGGDFNAPHTKWGYGHSSKKGKDLADRIEKACLTLLNEPASHTRIGAGPHRDTTPVTPTTPSIIGFMYPFHQTEYEADEAAVTVHYPGRSGPMPFQSPSKSALKKRLLKGHLMGTPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR89</accession>
    <name>A0A9D4PR89_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR89"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055714"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21141" checksum="EE2FEA84B7A91A38" modified="2023-05-03" version="1">MLVSPLKGNDSNRVVAVRDEGRILRINSATFDDWPGVVPGVVTQAIVRWFRSASSSSSSSESASSASVAAVSDPALNTASPTVPPVLASTSQDAAVSEKADLNLDACGAPSKSTESVTSETGSQQDDQKDQKKKKNRCRICRKKVGLTGFQCRCGGLFCSLHRYSNEHDCTFDYKEMGAQEIRKNNPVVVGDKIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS39</accession>
    <name>A0A9D4PS39_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_008805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS39"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051391"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000144">
        <property type="entry name" value="Malate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="175"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="344" mass="38641" checksum="43181000F5922412" modified="2023-05-03" version="1">MSEQEFLSRVGSHVTVRQETALKEPIRVLVTAVTTELAYRMLIPLVRGDVFGVDQPMVLHLYDESENISDMEGIAMEIEDCSFELLKQIVFTGEDEVAFLNVDVAFLNDSVPVDGDRALFEKCVQTYAGHGKALSAHAKKTVKVIITGHPINTNTYVCIRYAKNIPYENFTGLSRLNHNRAVTLLSQRLGVIPNKIVNMIVWGHRGDMLLPDYRRSVVIKKAKRYKISDLVSHDYLDEGLPEDVKIRDDLVQKLTKHPGILSRAKAALRPDARLVDRPAGGDGVYGVPPDLVFSYPVFIDNARSWKVVQGIALDEKLRHCISESAKDLERERDEAMEICTELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUH0</accession>
    <name>A0A9D4PUH0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUH0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045839"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36690" checksum="526F1056D43592D8" modified="2023-05-03" version="1">MCMFADTFEGDFPTHLCTHLVFMNAVIDLQAQIIRPNSAEQGRAVLQRFINQRREQEEGGSHFLVSLWEARVTDTYRDLFTDWSRGTRAATLALGWLQRTGLDGLALLNLALTSETAPDFLNIFKVLRAVMGPDLLMVFGFYLSESYQGKEEKRLIRMLHQIANQVNLTVFETHDPRPVSCKVFVPNAYNKRNEDADAPDHTILQCLQWSAGPAELYQRLQGRLCMSLTLAAFRFIVHVGPGHLGARCYNYYPASLRQHCRDKRQVHYADAAIGNFAEMTLILDEYPALCVALYHADLEDYRGVCDPGEPFARITAVRQVSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVY8</accession>
    <name>A0A9D4PVY8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVY8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039522760" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8878" checksum="9C3866E222A9B7F7" modified="2023-05-03" version="1">MAALLLRLGAAVNMAARLHSPFVAVNMAAPPHRGVGEAVNMATPCRRIHSFRISIELWARVRILLHIVQPHTVFFAGRLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWC9</accession>
    <name>A0A9D4PWC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049237"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="22"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7955578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="417" mass="44671" checksum="56376911B40F4314" modified="2023-05-03" version="1">MTPRTGDAGATTPRTKASPDECWHVAVVAGLLTCLAAALTRSSGFLHVGIMEQYGVDHEKASWPISLASVLNNMAGLIAGPICQKIGAVPVLHVGCVIMWVSLMASSFSPNITWLALTMGALFGIGCGTTFMTLHVLVNQHFQKYTGLALGIMYTGCTASAFIFPRLLLFLANTYGFQGSMLIFGGIVMHASALALLLKNPGWARSKSKLQKPPHGEAKPGIFTVESKEKSITEVSQKPATIDNQRRPDPTSLAYGVTVMRSPMLYVILFTYIVLNFNFGVFVTTVVDFAVDRGSTVASAVNIVPLFSITDTVGRLGLPVLADRGYIRRSTLAMLNYILMAASMFALPFSSSYAGMLAVCMCIALFQGCGIPLYPALMAEYVGIERLPIGYGIVGTVAGPLYLLNPLFIVIRAASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWM3</accession>
    <name>A0A9D4PWM3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWM3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14492" checksum="6ADF36127AB8C022" modified="2023-05-03" version="1">MHKTPPGSRNTSPVPVNTPVHRASRRQRGLPPEAPEQPTDAVTMTSPQAAMEVPTNSTEWIREIVRSVVREEMQKLYGPRQPEVGSIASVIRDEVQQLLHNRHYQSMPTNVEPAPVSTDIWSPPQSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWW7</accession>
    <name>A0A9D4PWW7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWW7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17951" checksum="9BE7A46CAD5E4456" modified="2023-05-03" version="1">MASAVAVSHEANVPDSIVGMFVWNCVLPTLPRNKKTVAKPQKVELIENVTVEEWVRRTLELGPKFCFQPQLKAAQALAMGRAVADGVPETEKPRCIAECAGRLDLWWRTKKGFSRFYRRRFSLKKPSKLYRNTSNHLLENRLKLRRRWSLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY87</accession>
    <name>A0A9D4PY87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY87"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="16766" checksum="49BCD53F57E3742F" modified="2023-05-03" version="1">MPPSDLKALIRAIIREELRDLEQQRSTAVSTPPAPFDLRNLVKQELAAMTTPTAPVAPPARPLPTYADVASLTTPTASVAQTLMPTYADIAAIPPAAVTSGPADITCGHLASVREEIQQVLRKGPKFSVEPTLRPEEKIATAKTVSKLAKEEERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZW2</accession>
    <name>A0A9D4PZW2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZW2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF38">
        <property type="entry name" value="IONOTROPIC RECEPTOR 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33484" checksum="1CD371EF2D8087E8" modified="2023-05-03" version="1">MATRRIDIMAYSVGPSPSRCQRFDFATYEFRRATFFVQNKWNRGGLILTGSLSWASLLTLSVLVTAGFFVLLNVRHGHRPFEGISQLILALVAAVLLIASPVRKANEPCTYSRTVIACWLLAGFYLAAFTQSLLTATLSAQPTWDADDTVDKLVPKLRHAKRWARNKHQFTGNINACADRTTKGTHLLITFDKEPCQLSGLAGAAVEGKSSILSVFAGFPIRKYYHLQGPFVSLIRRVFETGWHVRHERFETFNCTAIQDVPAQKLRTNLLVKMYLAVCASIIGVFLLKVLRYRRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q062</accession>
    <name>A0A9D4Q062_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q062"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026095">
        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="80" mass="9208" checksum="BCDB609B55A35EB0" modified="2023-05-03" version="1">MADAKKKKKKEAAPAPSQLWGEQETALLIGMWEDHLVDLRRQKCNASVYDAIVEALRQAGFVRTRLQVQHKIENLSQTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q197</accession>
    <name>A0A9D4Q197_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q197"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046918"/>
    <dbReference type="OMA" id="ICEGRCC"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19296" checksum="42CFFDF50D716E92" modified="2023-05-03" version="1">MASACGQSVFGFGADLDRRPTIFVPALPSESLCSLCGMLPAASFMLPCMHRLCGSCFFQCRHISDHCPIDQRVFRQEEVAPALIKKEAILDFRIRCWNAGNGCDAEDAVSVMLDHFANACMFHTVNCQKCGVKILHRELPGHVMSGCAATSSPARYVDDNACSQRLDLCARVCFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1B6</accession>
    <name>A0A9D4Q1B6_RHISA</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007672</name>
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    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1B6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038680283" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13208" checksum="0C468A6B4719FD9B" modified="2023-05-03" version="1">MGPASCFVVLLGCAALFFSTPVYGHNTGDGADEEKASERLDIVATVNYGLRMSAVLGLLWLLLLRVVPQLAVFSPWFFNGMALTVARSSTDAMLDTVLRWARFAHSVPSCSAAEPLQCLQSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1N3</accession>
    <name>A0A9D4Q1N3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1N3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028083"/>
    <dbReference type="OMA" id="YRCKQPL"/>
    <dbReference type="OrthoDB" id="6500587at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7962754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="566" mass="61659" checksum="2FD6B8880B0C1DCF" modified="2023-05-03" version="1">MTFLISPILPTKALLVSESFDCNDAFGHGTFQKRLMLLCALGAFLANSHALAFSLISRSVDYRCKQPTPQSNMSAAEEAEQLDRCLIYEAEGNVSRAVPCREWEYDVERARTTVVSAWNLVCQRKLLIAVMSVVQNSGAAVFALVAGYVADSIGRAPVLVAAALVLLVSASASCLSGDYVTLAALKFFSAGSSTLTLIFSAISLFEVTTHNNRPLHVAVSGTLGLLASDVWYFFMLQWSLRWDLELAAFILPALLLLPAYLSVYESPRWLVAAGQCQRAEGVVLAAANTNHFPLPSSACLLDKVKADMNRSADRRETIVDALLSGISIRQRALIMFGSFFSNAFALYVVVYTKERRSMPWQPYTSFFFNFTGYVIMHLLIRKVTMLTVIVSLFAALCVVQCLFILNVTAGESAVVTEALTEVHVAFYYTGGIVCFVYVLELFPTALRATAIGWAYACGRFGAVSAMLSLLLKNIGRENVAFIAAEFILFVSLLTLRSLPPATAVECTKMASKRSSLASKQNIERMKNTLATVQADGGSKKSRIGSEGSKTPSSVRGGRSRRAKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2G2</accession>
    <name>A0A9D4Q2G2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2G2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029810"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038975982" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21032" checksum="8C0691159183ABD7" modified="2023-05-03" version="1">MIFLLFWLLLPAILFAPEAPPSLIATGHSNPQPKRVKCFYFKTRPLRTYCHVLGLTGIITAQVAEEECRAISMDIISMNTTPMHRLCTLMKHFGLEEHKLWLADVLDRSDTLTWDECNIEVLAANVTKAPSNCTICNIAVVCDVVMEHNNEDVEYCYHDDKASAAESRQNCLDQPSPSSMLWKDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q301</accession>
    <name>A0A9D4Q301_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q301"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040971"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18372" checksum="46E86B56FB2017DE" modified="2023-05-03" version="1">MAEAFCYNYSNGDHNHITTSTESTLIPVVLAEGPFGPQGGFFGGFRGPLTAAAATPGISSLEPVYPPQPYSFGYDNVDEFGTQSYHKEQSDANNVKTGTYGYRDANGIFRRVSYVADANGFRVTVDTNEPGTAPGSSADAVFNAKPVSVTVASKSASAPIPAYATPGVFGPAPWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q330</accession>
    <name>A0A9D4Q330_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q330"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21092" checksum="40E4062F587691C6" modified="2023-05-03" version="1">MASVKKRKNLYFATKLKAIQRVEAGEKNSMVADDIRTLRSMRSILLKNKAYIKAKAAEQLTSEACRVHAPAHGKVEQALHGDDKRIDDAFRELSSLFPAAVPPEVPADNFVEADCNVQAVASLTDENMVAAGAGTQDAQADSSSGDEDRLDEAVATCAYFAAEVAAAFGLIRRCCSDMEGTGLSHLESRDKIEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3F9</accession>
    <name>A0A9D4Q3F9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3F9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039521457" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8589" checksum="347DDA5B88107D63" modified="2023-05-03" version="1">MVKSLLVLFLVVAVGCVVLRCADARLLEAKDLTDPVTGLLDNTVQARDLTDTLVPDAGKKALKPLDKDGSSPSKVDQVGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q422</accession>
    <name>A0A9D4Q422_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q422"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027187"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="29307" checksum="8058D2E94CF40C6E" modified="2023-05-03" version="1">MALAGKNGLSLCAVPDAQIGRHVRPVAFAHYTSSLAAAEEFRRTRSRRTIYMQMLSRLSFTLQRVPFRKVHIPSGLDYRLALLEWCSRLLIVSHVMTPVIAQASTDAEIEAAVSPPMSVDIGADCGMNEAENAGGVNKKLLQAARTTSCTAIGLWSRSIIKHLYFAVQRGGGNGDLAVAVWLSITNHVQDKHHGHSFLYDHCQHGDLEPRKWIFPGYVDRLFDILNEYIDGAIPFALPAKPPHVTSALGPIDKTELVQSHLSWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4J6</accession>
    <name>A0A9D4Q4J6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4J6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7967850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="16381" checksum="0154540DB2C73755" modified="2023-05-03" version="1">MLAAFAKQSGQDCEATDEGGGLADEDKTELVKKHHEYRARIVEKVKVSGASILEGGPSLVSITGIMAAVLIGGLVLTSAVLMRKRRLRHSATAAAATKLEAGGSVRAQLVLKSTRRSRRLPRPPNPLPATKRSRRSDGAVGWPYPHPGLAFAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4W8</accession>
    <name>A0A9D4Q4W8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4W8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044581"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038855194" description="Granulins domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7963116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="213" mass="22432" checksum="30BCA8B0D8958FA2" modified="2023-05-03" version="1">MLLLTLVFLLLATPTALAADYKRCPDGSLCHKTGTCCLLPVGRYSCCTLTNAVCCSARSSCCPEHYICDEASNLCAPGGAARKDSRNQNATTTTAKAASKYTVGARELHMTKCPAGDTYCFRDNSTCCRQGTGSYGCCPDKDAVCCSDLVNCCPRGFACIRGTGNCVQTASFAKLGAAAGARRTALHARLEGSDIEEPLTVAAMPLERGRMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5H9</accession>
    <name>A0A9D4Q5H9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5H9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032697"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048506"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="252"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="39170" checksum="91591384549E7BE9" modified="2023-05-03" version="1">MASASQAIVFPTTGWESDLSCLPPLNEERLVEFYRSKSTTERCYDRSYNFTVESYLIASTSKGFSEAPEDIACTDLPQQWRVPRGKVIKGSSVQGIDWRSVREGGLSVPKLARPTERRVNPRTKEEQAAAQKKLCRSILARDANNAFARGLSLSLGQPYKETKYGLAPASSPLAYQQALLPHGFSAQLSGITPVSLASSQLVPTLDLFKDVEPWIPAVHQTTSGILEKVRTTRESSLTLERDTRQQSRSATWQKERAPRLTASNFGVVLARQQWSSKGLQAITASRDLSRVAPIRYGTSNEPIAAKRYEEVLQNMGHDVTVAHCGLLVNPAFPWLGASPDRLVYDPAEGSYGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q640</accession>
    <name>A0A9D4Q640_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q640"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15208" checksum="417B3FC882A18929" modified="2023-05-03" version="1">MGAEERISLILAGIKDIKSANPQAAQCCNSVLELIDRATMLDCRRSTPTAEERQSKHGDFQEKKASGGYPMPNNATNTQPAETSQEPTVDEPNPTSAVSSSPSPTTPPLRRSTRVRRPPGYLRDYEALPFSREGKMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6S1</accession>
    <name>A0A9D4Q6S1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6S1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042158"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="22545" checksum="E3AB631AFE9757FB" modified="2023-05-03" version="1">MNTLNGVATEDSALLMSVSPQHHKLGLSHMRNPNVSSVIVGSILGTTRAGEPVSSLMALATLDGTLMLVDDGDNILWSLQVDHQLFALTKMDVVGDGREEVIACAWDGQTYIVNEERQSVRFQFDEAVCTFTAGNMSLSSGETQPCLVYATFNNRIVVYYNITFTNMATQSLLDDAQLVAAVNALVPASSRASEHPVEGTDSDGGTEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6T6</accession>
    <name>A0A9D4Q6T6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6T6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="294" mass="32805" checksum="38E94CF4FC1AA151" modified="2023-05-03" version="1">MATCTPRILDRQTACRCSLSTTGLITAPHSTLWFPCWTRHFEWSPWTWWATGASSNLPRGYQYSHQQFVEDIDDVLDYLGWSYCAILAHGVGATMALYYAGLRPDVCTGVVSLSMSDTVNTHPGHMLPTLVQHIEASGNLEYQKADKETMDTVVRDLVDVTGGSLDEDSARVLLGAEDEAGQTLQLAVLSRCLKVYTLSETKKDALTIQNTMTLYRGPLLMVSAKDWCDDDEEGMLRICEDFFRTSCDPFVKLEVDGTHHVHLNNPGLVSSHVSDFLRKSCDLSCPFPCLRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6T8</accession>
    <name>A0A9D4Q6T8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6T8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="345" mass="38617" checksum="05992F18EDA46B92" modified="2023-05-03" version="1">MTAMPIVDGAAALYGENFGGSYESIRGVPCPAESAKTDHKAQPDTSNLDHAEMECQDSEAGDGITHQDKEWNDGISRGKGDCDFSSPPSNSLAQPTPQRRPHKRKLPPLPKEDFKVIEVADISRKMTDLTLNGRLHAVKAYAAVGNGTRKGVINDNTPNTSTDTLLANLRIRTQGVDILRTRTLGETRTAAITFLGAITPRFVYYMGGEVPCYPFKCTIQFCYACEQTGHITDGCPTPHSAVCHRCGMKEPQPYRPCNPVCSTCGEGHLTRKKEYKQRFKQPVRQQQPKLHDQKTNKQVQRAEFSSPPKPRWYSSEDADDEEWPQLKNQADIPERKRHEQKPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q742</accession>
    <name>A0A9D4Q742_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_014523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q742"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051343"/>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000478">
        <property type="entry name" value="GG16802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7969079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="292" mass="34004" checksum="861FA5D99E9BE5E8" modified="2023-05-03" version="1">MAAGITDLQRMSWEDARETLRQWREENDRRSEETVELWHSVIAKNIKKLGDEKWVVYEQVCIAALDCHEMRLAKECLNKLDEEFPGSLRVKKLEAMQLEALEKYDEAFTQYEALLAQDEANSAVHKRRVAVLLSQQMVGEAVKELSDYLRRFMGDQEAWLQLCGLYLREQDLARAAFCLEELILCNPHNHLYYQRYAEIQYTIGNMETMELARSYFAQAVKLNPNNIRALYGLFLAASHIGSHPKSSVQKKKDNQRYAAWASQQITKKYQEKQCEDSQVKLLEGMLNTLQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7X4</accession>
    <name>A0A9D4Q7X4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7X4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="17975" checksum="1C939A855165357A" modified="2023-05-03" version="1">MQVIVMVCATVASVRSNVGTMGPNYGGASQQAQQAQPQLPHPFQYHPSFYPPLLPYPFPYTPSPYQLSHYRPELCPPQPCQPQQPYHGPQGLSGHMALAPTSDGGFFFSDPRSPADLGHYHSPAGERDPNEPVMMAGGRNNGAVGHSGSAVRTRRQASFPGQHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA30</accession>
    <name>A0A9D4QA30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056517"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11676">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046856">
        <property type="entry name" value="Gemin6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046857">
        <property type="entry name" value="Gemin6_Sm-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06372">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20417">
        <property type="entry name" value="Gemin6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18238" checksum="08019CFEDEF56504" modified="2023-05-03" version="1">MSYVHKLVRVETTEGNVLAGYVKTVDPISESIVLVLFEDEKPKVLHVVMGHAVKSVTVVTDASPAEKEQLEKLFMPTQQTLSAEELRQRKEKVRSWMCVNRIPVTESSQEPGTLVIAGSVRLLPPYGPDDFQCTNSLVLGKIRGIVSLMPADVESWTSPYEPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAB6</accession>
    <name>A0A9D4QAB6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025789"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="715" mass="76923" checksum="6B448951AFC283FE" modified="2023-05-03" version="1">MDMVFQQLGVRPRPALDKVTIPSSRHPRHVDTIRVPIRPQAGPPGPFRNPKRRGAALTLTRRACTSVMQRLAEPSVPPTTNDAPPVSPASCCATTAAAPTLSLSGAVSRPTPTTVDQPAAFPISAPAPATCNAGSVLETPSSTTLPPDPKSVNTSSASQSAAHDAVPTGSAPGICKENSMCADKSVLKSGVPLVPTVLPSTIAADDSSTEMDFTASQGNEDNTSYPEGSWNTVRANRKPASTARPRTELITVGIQLPPATLTPKYLCTTCLLPSSPPQISRPDQRKSPSGQTSSEPCVPENTLPSHCPPPPLSYEYELNGKPITIKPYAPNPPISCLGVIHNGTVLTNALSTALRPSAAAVQRFCLQILLLTFCPTLVHPLPSQYSFISRLPCPFLLAKQRECAKAAFLRRTALRRTTQPCPPSSSTHEFRSPPATSTPGSYAAKVKGASPVYPPSSNNTPSPSMGNERRSFDLGLAMLERNQREQQRVSDELQQKIHALTQTLETTTSSLTSELADQMVTWSKPPPPHTTLAWFNWKPRLSGFSPPSKPNPSNWNPSLLCSTPCKTRSPGKKEGTRTHKRLRHCNDLDGAWKGPRDFADPSPNIPHSPFPTPFSSSPKLGRPAPSRATVLPCYDGHATASIYVRPTFPSNHLTTGIQQPSRSLSTPIPDPDPHFLRLWRRHKPHNVQLSSALMLCVLKSWLTAHPSSTLVGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDE4</accession>
    <name>A0A9D4QDE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042751"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044978"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058203"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7976355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="709" mass="78911" checksum="B757533BAEBDE77C" modified="2023-05-03" version="1">MNRPCCVVGCKSSDWRQVKIRHRVPLEGSRRAEWLQRIGLSVSDRRQDIRVCGRHFKPEDYELSSVFMQRFGLDLKRHPLKADALPSLFLPGGKRTTQKTVRKAGMRTVATQTTVECQSVATQVHMGLKMLVSTKTQTECSAAPHEAPVAATALVAAADVAPVPQLPADFRPLRGSTPVPIDDSFTADEEKPAAEVDVTYLPSFSESFCSTHQDESTAVPTGVEEPLHAERKFIVFESSLRELLANCSVCGQAVGNLNFSVVGTLVTVEGVCEQQHKLRWRSQPLVQGSGAGAGNLLLAAGILYSGCVVAATIRCLNSIGVQTITERTFYNYQRAYLLPAVKQLFLKKQAVMVNALADLQVDLAGDGRCDSPGYSAKYLTYSVLAMQNGCILHTEQVQVGESPEVPNSVSMEKHGLAKCLTAVEKLGINICSLTTDRHPGVKQYCRKNKPNMPHWYDVWHVGKGLKKKLLAASRKHRVLSPWIQSIINHLYWVAAMGQGDGDLVVSMWRSLLNHVCDKHDGHDGPYKKCLHDQLEDREWMSPTSPAFHQLKTIVDNPLLLRDIRRLSPEVQTFSLESFHNVLNCFAPKSNAFSEDGMQARTWLAVLHFNENAGRQQALTREGEERWKIKSSKARRGHFTVAAVKEEPSYGYVEELLQHALDLCEHSSYKESFQGSEEAAPCHMSLAYERPSKEELIAQRRTRFPTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEA0</accession>
    <name>A0A9D4QEA0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitogen-activated protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEA0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041674"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11699" checksum="97407D54E76B2BE6" modified="2023-05-03" version="1">MLQLEEVYLNMHAVIPSKSPALTSSRLTIDLLERMLELDADKRPTATEALAHPYLASLADPSDEPSAEPCDQSFEDRDLSVHEWKRLVYEETTSFVPPAAANSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEG9</accession>
    <name>A0A9D4QEG9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEG9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000019">
        <property type="entry name" value="Glutathione S-transferase Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7976274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="20140" checksum="000D38C2D60D8E10" modified="2023-05-03" version="1">MTSILGYWDIRGLAQPIRNMLVYQGVEFEDKRYVFGPEPDFDGEEWLSEKSTLGLRFPNLPYYMDDDVKITQSLAILRYLARKHELAAKDEDETLELDMLEQQARDLSWGLLMAGLDWNRELNAGAFEGFPALTSYTKRFEELPNIEEYFASDKYNKYPILGPMLKWGFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QER5</accession>
    <name>A0A9D4QER5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_016804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QER5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050298"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7976581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25813" checksum="9B767EFD2D12861B" modified="2023-05-03" version="1">MTTPCTVYFFLPVLYELKVTSVFQGGLRGVVWADCVQGIVLFAAPFVIIGKIIYDSAHLDVPLRPLSDIDPSQWFMRFEADASSDETVWTHLVATLPFHLVREGMDQMVAQRFLAARSIHSARRVMWVGTTMLAFFVLSTTFTGLALTYWYRDCDPMLAGIITRYDQVVPLYVGQQLAGVAGLRGLFLAGLVGASISTVSSVINSHAATFYVDIVSPNIDLGETEAIWVTHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEX6</accession>
    <name>A0A9D4QEX6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEX6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055075"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7976671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="521" mass="55955" checksum="7D7429BCEC5D8C8A" modified="2023-05-03" version="1">MSGRQPCKRQLAGFDQLLDWRPLDFVDTVPNVFCCTLCGVMPAFPKRLTPCCHVFCQPCFDTLVQREHRCPLDQMQFTDDAVETLDSVRGGIYQLRALCPNASSGCTVVTVLPHLKDHVAGSCDFNQVQCPRCGAAVLQKAVLSHYLEDCAGAHRKVASPVSSDTSSVGSASDDDAARRSDHRTPRSVKGFDKAKRQKGSSIGVHRPSSSETAGTAESNPDLVAAIRSLLHDTHGGSIRSASRKTIRVPSVETSLIKTGRKSASSTKSDLPKWVTAKASKSAEGVPEDDKAFLQKQPLGRVDSLLAKVTETAASVDVAAAVAAFEVAEASKSSSSSSASSSKKSASSYALPHRRSRKHDSKRAKGVVRAGAASPAGFACCYITGVLGAEARIACGEELVLRSDSSQLADCTFRVHARLRRDAEGSVLLCFTLCLCGGTWRQLADWTLANKVSLLLVHPWDQARNRRLPLCLNPDSVPLPKESVPHPVRWDFWSPTCELKLKELAAGGFVSSGAICIALEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFY0</accession>
    <name>A0A9D4QFY0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFY0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055044"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19687" checksum="0C5429B4545E8CF9" modified="2023-05-03" version="1">MGLRESVTTAMAAEKCMSDECIRNLQFLDQIMHFGIDPCMTFHSYACGRFMSPTKYMLEKMNHNLATRAYEQALGEKVQAYPQTLNAEQKAFKLFHMCLDLHNAKRKQPEALVKVLDELKLNPASIADEVSEDPLDRMMETSFTYGVHGIIEFVVDSVVIVKKKRLLKVEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFZ8</accession>
    <name>A0A9D4QFZ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolases family 39 N-terminal catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035371"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003940">
        <property type="term" value="F:L-iduronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049165">
        <property type="entry name" value="GH39_as"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="6">
        <location>
            <begin position="86"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7981793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="341" mass="37913" checksum="94822F0EB100DF64" modified="2023-05-03" version="1">MRLNPRHPVAELSGGQQSVEPSSTPLAWSFETCVLVCTEGAEMLAVVVVLLFCQAVEAESTCLDSDVLYVRRLDAPKQTTSKSFQVFVNASDVVGVLKPFWKSTGFCPPEPHNDPEFFLGDDMQQNLIYIASVPGYGATQVRMHWLLDLVNASASSEMGGSTTFDFGLLDTLLDRLRALGLKPGLELMGNPFPRPLDFEKRADLDLWKELVTALARHYLERYDEDYVTQWNFESWNEPDHKSYGSNFTEQGLCNYYDACSEGLSDASPLLRLGGPAENLAPSHRSPLAWTLLEHCESGVRLDFISLHQKVQGSVVFAIVCHRTIAEVTEKTPLLGDAPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH41</accession>
    <name>A0A9D4QH41_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH41"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="60" mass="6856" checksum="BF58979033847E88" modified="2023-05-03" version="1">MTSNIPAFPEVSHGDIVNYFVYSTNLVTLGEIKAYKPMESHNYFTSGWVKSQSAKELRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMD6</accession>
    <name>A0A9D4SMD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_004796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030514"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="237"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7935208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="325" mass="36602" checksum="FAFF7A73537EF87E" modified="2023-05-03" version="1">MPRVTSTDDTLSNGMSELNMSQESEMMESESQDCLGSQDASQDCLGSQDASKARRLRHAYRAVIDKQLNEAENVLPNEALRKAKKLFEDVTRTTEAVLDSTLVSLAASRGRQLVNALPVNLRKFDPDEFAARVRDFVSDTSQTDPLTEKAWAQIGKLAGGNMRTSHPFWYLYGSAGEVPVKTRQAPVRRQLPDGPDRAPTVPKQVRSVEQTNQETTTERVSVIHQLLRDIYKEIRRPLPYFELVLHPHSFAKTCENIFHLSFLINEGHARIKRDANELLVVEPVFGNTNAEREANKSGVFAMTMNMQQWQQAVKALNITRPVIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPY6</accession>
    <name>A0A9D4SPY6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPY6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13483" checksum="4B675270C0316588" modified="2023-05-03" version="1">MTQVTCLQLKTCSNVNFRIRTHITGPPERISDGATLHDIFIPAEEHPKKSSYKWVAWRGSTVPENAVPGGEDTYVCRAIHDGKFTPGKLFTPHSKCYISYGGFEHGYDEYETLLGHQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQI5</accession>
    <name>A0A9D4SQI5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQI5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="84" mass="8975" checksum="E01A9CCC1E0B75CD" modified="2023-05-03" version="1">MRVGAPTLSQTSLSLHWGLILGSKRSNQLKTGAGDINSGSSHLFIAVDSIISIRRLVTAQPSCLTFPPRLQITNAASQGKRSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQP8</accession>
    <name>A0A9D4SQP8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_004423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQP8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050174"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7943059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="18051" checksum="792290583D4F9412" modified="2023-05-03" version="1">MRRFLAATLGNGVPGSNIHFFRFPSVKRDRQRREAWIRAVKRQNEDGSPWQPSDSARLHRSAMFPDFAGSPSNSPRHPDFVPSLFVYTDEFRRSPYVDVVDNSLNMRLRTYPSSRNFCPLVVCREQREPLAAIKASDCFLLGIFIDAGLVVHPLATEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRR8</accession>
    <name>A0A9D4SRR8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRR8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051821"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="374" mass="42252" checksum="D693D5342A268FBD" modified="2023-05-03" version="1">MGSKTNSSRTFPTDGLCEYIFYDSVYKAGPVEFEPYDLDADFRLFIDERKRFAATEFGIGYSFRYAYYLKEVIASTTAPAPFMMWYLWRHRICHFGVVDTPTRDLNESYVTAALESLKIADKVTDQHRAKGYVCITVFAAVIPDDTWENYYLDAFPNIFTPQLFIALGHYECGDNTFQDCHVVPPTLLSRPAQLSAANSSYQHDMTVTADSVGKMAARGVKAVWAISVTMKGRWTVPEETETPGFLCACAYDPEAKSFGSYAEVCNDPKFGHEYNYSLELHAAQYYSASDHRLFSFDDEVALGQKLCTVKARHTSIDIGIAVFDVDYEDFDNVCARTNWGGKFSRLRAVQLLLNFFRTKFSDPSANDTCLGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSW5</accession>
    <name>A0A9D4SSW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_010067</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042544"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="13">
        <location>
            <begin position="141"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7947325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="381" mass="41544" checksum="1AD125A290A7D0EF" modified="2023-05-03" version="1">MDASSYQELRDIANRLRILSIRATNASNSGYRTYCIIGDGESAEGSIWEALSFAGHYKLDNLVAIFDINRLGQRIEDSDNWHGKPLGDKAPAAIEALEKQMVSKGPWKLSPQRPEKEDAPPVDISNIRLSEPPNYKIGEKVATRLAYGVALAKLGANNSRVIAMDGDTKNSTFSDKFKKAHPDRFIECFIAEQNLVGVAIGCGCRGRTVPFASTFAAFFTRAFDQLRMGAISQANIKCAGSHAGISIGEDGPSQMALEDLAMFRSIPNSVVFYPSDAVSCERACELAANYKGIVFIRTSRPNTAVIYPNDEKFEIGRSKYFSALGGIGDAVRTAVAMERDIVVKHLAVRNVPRSGPSAALLNLFEIDAEHIVKAVHEVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STT7</accession>
    <name>A0A9D4STT7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STT7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054249"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="155" mass="16664" checksum="ADCDB88C2085D569" modified="2023-05-03" version="1">MESEEVVTCCASTRPVLVHSKPSSAMMHHARHSSLDLRGHHGPGIARAVTPPSSSSSHMPRKQQHQRNLSLDSAMRVLSPSHHSDTTDRHSLASDDSGIFNSDDGDRTSRVNMEASTPALLPCTLRPPVQGVIDEVRSPVSPLQEASTVDAFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUH1</accession>
    <name>A0A9D4SUH1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038472"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="324" mass="35497" checksum="F5E1FFE856BB0AAC" modified="2023-05-03" version="1">MATPPEAATLPETASSTEVATSTETTTPPETEVQPDKDLELDAPTQARAASSEGQPLPKKRLFNLRLEAKGQSESQAKSSKDASTSEPAHVEKPKMVTVNGSKSEGDPCWDNMSNRSNDLEEHADAVEQTVNRDLDSGEPGPVTTATGALFLHTYCGERIEPEEVIKIKLLLQVAKRRLALVERKLKRKSEAYNELLDANKELKFELSLAQRPTQQQFSVSNQLPQELLRDWHENVGRVPHARRYSATTLRFAADLHACSRTAYEHVAHWLPMPTPYLVRRHSAMSSPGDGSQESGGVVAATTPSRKGENTSAGPRDTTVPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVG8</accession>
    <name>A0A9D4SVG8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_021468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026888"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7952328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="363" mass="40499" checksum="6CF80E3C80616A14" modified="2023-05-03" version="1">MFRFPANPGRRRLWLAQVKRDDWEPTSASRICSDHFKDSDYELRRQDGLKKLRPDAVPTVFPVRVVALSKIDPSKYQGAVDTLMLAQDTLRHMKMGPTAHWKPSQAGLLISTSVVLSLAEELLSLRGYKYLLTSRLIQDCLENVFSIVRMKKPVPSAYDVKSSLKLICVGQFLHTPKSSSYDSDDGLHLADLLGASLEKSLEEFINDEEHLENLTLDEVSSVECDILAYVGGFLLKTIIKAIGECPPCTAVLLGDGQCYNALIELKEYVKGATNLLRPSAAVMELLVHYEEHFKGFVAEDAILDLKAPFRTISRGYALSLDPQGGVSIAGQRRHLGGRAIRARSVSTYRATFRVRSVRFLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVI1</accession>
    <name>A0A9D4SVI1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVI1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7950961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="721" mass="79465" checksum="513E8C5CD129CC4C" modified="2023-05-03" version="1">MHSEEDLPADEPKPEAVKSTESKITLPAEQPEQPPPRRDYLSWNPTPVPADVSPAWQPEQHLARAFEAANSGSVSSLQPALLATVAALMLTLIGVAYYVRMVTTAPCSSPACQRLQALLDANLNASVPPCVDFYGHVCSRWEAAHSHSVRDTIYQELMAKVATMANEATPPQRGQTAMQKAAMLYQSCAHVYTLDRNHMGEARSLLADFGVRWPELSNTSRLLRIFVSMSTTWSWASVLQFIVQSNGHVTLRPSPFYGLVLSGRQRMLEKSTDKDHYQAYYDSMVAAFGGVNARAHSYREHKMLEDKMVPALSAALATPNWTALENSTFKAMVNKTDNPIQSSEWESSIRSSLNFSEGSVLLVSIENVYFFKQFFALVVSQSEAVMAYYVGWVVAQALSLLSSSETVTKYFISDKALASREHALFCADITHVYMGIAFYADYLSRQITTRVLVDVLTVETTVQAALRRHLGASPWLGAIPEPMLTEAGLVGSLRLLEAPNATTLDDMYGLFPDMSENVFDNVRLAADARAMTAADISMAEFVTNGSARLSFHPAHGQFELLPEVLEKPLYALEDLDAVKYATLGGEVAEAFSATAFAETTDRKLQLAFTLKSACFFGSQVLLRHLGLEHVELVRRVTSFHVILGALAEATNGRVQTARLAGYEDWTDVELLLVIWCFVQCGGRNGRRKCNGPLTVVDDFARAFGCKQADPMYSGRNCAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVK5</accession>
    <name>A0A9D4SVK5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_023469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVK5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043708"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039753587" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="40"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7952448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="540" mass="60315" checksum="DC8489D2A101CBDA" modified="2023-05-03" version="1">MPYSAVSVLSVVLSVVFQVLFWNAEPCVCSGSADVENQRVIVKTKQGRVAGQRVTVDSNTIYRYIGVPFAEPPLGKLRFRRPQPLKPWKGVLNATSYTPSCMQMPLQVDEKVYLDYGKRSEDCLYLNIWQASGARTCSGDPTSTECRLRPVVIYFYGGGFLTGDASFFIFRGDRFAAIADVVYITVNYRVGMFGFFKTNMPEYKGNAGMFDQVEAMKWVKENARAFGGDPEEITIWGQSAGAVSVTFHMLSPVSRGLFKRAYIQSGAPGSALALMKLNTPAVAHRAMGLLGCYKPTIPWKQQEQESMKCIQSVDANVLLEKIARELPLTSFLFLPTIGDEFLPEDPLAEGQKIRTGKEILLSTTPNEGSLFVKGMLLRNPHLRELISEDYKTPVKILMRLLLDVPSYKTEALADVYLKGMDKGDMNETEWKTNLGRLFTDAVFECAVDSFALAASKNGHDVYRFLFAHKPTFSIWEDWLGITHGDDIIFTAGTSADLTRSIKMYGRYPGDHSIALPEPTEDEMEFSRDLVRTIGSFARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVY4</accession>
    <name>A0A9D4SVY4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031725"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7951381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="116" mass="13120" checksum="77E11B756EA3A17F" modified="2023-05-03" version="1">MRDMGLAADANKAIPMDVDAQPTTKGKRKAPAPKAHVVAQLEAHASEPRPSTLRMSGDDVKFCVYMLEKYGEDYAAMARDRKNHFQDTPAQIRQKINTFKKIPEQWNAYMRAKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWV6</accession>
    <name>A0A9D4SWV6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_023830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWV6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035969"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06902">
        <property type="entry name" value="lectin_ERGIC-53_ERGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000028">
        <property type="entry name" value="Blast:Protein ERGIC-53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039512666" description="L-type lectin-like domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7952495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="510" mass="56889" checksum="4773B374C736D91E" modified="2023-05-03" version="1">MAASSSCLWFVVLALLALCSCTANIGHRKFEYKYSFKGPYLAQKDGSVPFWDYSGSCIASEEMVRITPSLKSKKGAIWNKNPVNFPWWEVELVFRVTGQGRLGADGLAFWYTNQRQAEGPVFGSSDKWIGLALFFDSFDNDGKHNNPYIMGMVNDGTKTYEHESDGMNQQLGGCQRDFRNKPFPVRAKIEYYQNVLTVLFHNGNTNNDGDYEMCFRAENVFLPQNGYFGVSAATGGLADDHDALKFLTTSLLPEGQQPVATQTIADSEKEKFSREYEQYKDKLERQKEEYRKQHPEEAAKHDMEHGAGAEQPYDSPQQRELRQIFEGQAHMFEGLKAMHRKLDEMLGRQERTLSLVSGIQQSGAGAVQPQQPGGAPPVQVQSVMQRHEVDSLLNSQRELLLSVQQIKTLAAEVQQKTGTLLSVQQQGGAGGGAAQAALSTEHVQLLHQVQEKLAAFKADSFAQQKLPVTGCATTCLSPTYFLIFSTLQLCVTLGYLMYKSSKEAAAKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXL1</accession>
    <name>A0A9D4SXL1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052034"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7955883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26430" checksum="4DA71E926554C49E" modified="2023-05-03" version="1">MVVTVNECAKDMIRNFADAESKGTPCDVKLIFGAFGLDVTAQTTFSFRLDSHRDVHNPFVLQAKRFFAAENNWRAFFSFQFPRLSKMFGLRIFCPDAVEYFSGVMTNLLQRRISENKNEKTDFVHLLMNAECHEEDGHQQKDTGTRGLTKDQVLAQAVLFFVAGYDTTTIAMSMAVYYLAQHKHIQERLIEEIEDVLQKQSDITYEVIMGLQYLDAVCMEVLRMNPPVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXV1</accession>
    <name>A0A9D4SXV1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein MAK10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXV1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028976"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14795" checksum="E6F667FEB1E06BB0" modified="2023-05-03" version="1">MHEPSRARLSDFRLGWVRYEHRFAPFNSILTPPPVQYGQYKEMTDPYKYQPPPTPEDMYLAACKCFQNARMLLDNVPDLSSELTSVMKVAKTNFVVVKLLLSGHKKDSTMLPEFDFSQHKNFPIIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ00</accession>
    <name>A0A9D4SZ00_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_012479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ00"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045423"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="33877" checksum="173FE9C95BF057A8" modified="2023-05-03" version="1">MTDNQDLSFAVSAVNAVGAVRPAESLMAVSGTNGGLDAPNVCRDFLRKVCHRGSRCKFVHPEGIDPDDIRGTMEPVFCHDFQNSECLRPKLQVSSLHSSESYSKFIGHEEELFRTTGRLPPSAGGVSEPPQVVGMIPPVCKDFLKGDCRRAGRCKFRHLGEEEPEAKRRALDDEMGYRVLQQENAILRRKVDDLKKQVADLMATNEFLLDQNATLRLSKQTSAGTQPLGVIPTAAALGPVTPLGGTADLTSTPQSMTPMMPVVPVSISSSLPASLSQSLAQTIITMSSPSAPLVSYPVMTQSLRPVIAHRMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZW7</accession>
    <name>A0A9D4SZW7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZW7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="342" mass="39402" checksum="AAE9078E1E54C721" modified="2023-05-03" version="1">MVMQLNKKRSEHTVSDQRKELFCCVFLFCCGILACKYLIIEQYKIDKHPVVPFPAICVYAETLGPSTPMPQDGLCDYMFFDSFYKSGVNKMDKTAVKSVSLDTFLKLSRESAYAITQMGVGFAQYGASEALRVINTDEGDAYMLELWKMQKVRHYGVLDVDARASNVEDILRLLQALRYQQKLSLEDEQVAQKPTAYIVVGVDVVKFLHEKRHLFTSSSVAISITMKARWYRPSNDDPHWYYDWLGVKFIYPYPGFEPGQPCTSLGDRQYFTSYFYYCDLREILNGVAYGIAIFDADQDAWDKNPCVDSPKNFDRMNMVRKLMDHVSKPGRDHYPEGCWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T131</accession>
    <name>A0A9D4T131_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T131"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="205" mass="21750" checksum="B938BDF706A59B06" modified="2023-05-03" version="1">MDETPATDRGTAGGGGTRLDAPGPSRGAARDASGGDRPADGSGRTAIRFLQINLDHARLASANLTDAMKEGGFTMALVSDPYRPGKKLPKPPSGFQYIAADNDPAAALLVARAPFDLCPLLITPSVVAVRQFTDQPGQTTKIMAADPVIAGLHRMDIVWTSWTREGLPLHRRRRRTPGRKRSSGRDGNAETSGCRDATTPPGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1P9</accession>
    <name>A0A9D4T1P9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_019585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1P9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="83"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="501"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="691" mass="77356" checksum="A37C6DA29D3E99CD" modified="2023-05-03" version="1">MAGGDAPALAVKEEAQDNSSTVLSYIIVVCCFALIGLLIFLLIYGEHVQMAIRKSEKHKHCEAPDCERVKKMMHLGPVSGELPCRDFYSYVCSPWASANVKGVNVSWLSSQKYVDDMQEDMKKRGPNITYQTVLDMVLITYRSCLLSATEALESGIRPVFNEFRLGSWPQFTYSDTETYDVFAGLITLDLNLGMKVVFVFENALFGEGVLQRRLSIKATPLACPFSPELNKSLEGTYEEYVREVLGLFSYNDDEAIQELVDIHLNVCRASIAMQGVRKSHTLREIAAVTRDMGLSELIWRKVLEPMGAMTASTILHVKLYYIGEALRCLLKNVPPESAMRFFGFSILTQMAAHQEPLRKVMDKYFFFNHPMEPSPKHGICRSINSSANKAQSKDVSHIVASIKNSMIRRIRSSQWMDELSKSRTLEKLKRTTVVPPVLGSYLKNFNLAERYADLEALSPTDYYGNQLKIRANNAQYNIRGVKRSTGRGNVALAGGDANWAMNMVHVYAGLLRLPFYSTDVPLAIKYGGLGSATGRLLALLFTGKNVMKDVLGSTSHWWTGGVYQEYKKRAMCFAQQANPDAALGEEADFLVDYLGARVALDALLYAMADRKTRLLIPGIALSDEQLFFITYCHVMCASVEFEGKLMLPERALKRCNGAVMNMPEFGRAFNCTHGKVDKEAILNPAYKCSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2D3</accession>
    <name>A0A9D4T2D3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2D3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="249" mass="28124" checksum="C28646FCFDF04A03" modified="2023-05-03" version="1">MRVRLFRAFLGAQLHRTHEPYTAEMQVRKHLRMADQMTEFHWNLQLRRLRGWVDKVRVSATCNVHVAEGVCLPHFVREVLRLGPKFAVQPQKKKPELLSIVRQVSRRAPEDQAIRIINEGGDLQASNRIGAPGHLNMALPRSSSCSDVDDMESEGGYVEATNRRLKRKLRRTSSVSDLNYNTPSSQQTRQTYTIAYIPVAATGNLNSLNRQALTAYLGNHILPEEQQGRYHMAFPAISECGSAGARKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2R1</accession>
    <name>A0A9D4T2R1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_002548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NUP54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2R1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046258"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000003">
        <property type="entry name" value="nucleoporin p54 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7967798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="608" mass="64604" checksum="BC5682C33B622C3B" modified="2023-05-03" version="1">MTFGQPANTAAPGTGFTFGQPAAGTGTGFTFGQPGATTFGQPAAATTTSGFTFGQSAAAPTAATGFGFGQPAATTTSGFSFGQSAAGQPAAATTTPSFTFGQPTTAAASTGFGFGQPAATGTGFGFGAQPSTAAPTFNFGSTTATTTAPAFTFGATTTTASSTGFQFGGFGANTTTTQSNPFGGTSLFSTGFGSSAAPSFGGAASAAGSAAAAAASAASNLTNLATALSLPAVFNDERDNILAKWNQLQAFWGTGKGYFSATAPPVVFTTENPFCRFKAVGYSRLPQAKPEDGLLALLFEKKLEDVQPMQAQLVEGLQRALGNKPNVAVCVEGLKSLDVNRCELVVYVMERAPTGQTRRFPSNEVVSYLEQATVKSQLTNMGVHSVISKAAATKDWLKVYLNNPPCGIDTLLWEQAKLDNPDPERLIPVPMIGFAELRRRFKLQEHEIKQHQCRLDAIAEDISKLQIQHTNTVAKIEEHKRKQQNLYHRILKVMVHHEVSRKMGFAIQPEEEHLRTMLESNLGELSAPTQFRGRLNELMSQIKLQNNQMTFTDTTIHCSLEPSSLSLLKEHLQTQQRGISELVKVIKYDLEELKKMESSLQGTAAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2U3</accession>
    <name>A0A9D4T2U3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2U3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="173" mass="18637" checksum="A12774DCC4495332" modified="2023-05-03" version="1">MSVDDLPSSGNSPTANEVGVSPRGEDVFQDFPSDKALENFANEYESVSRAMGVVDAGVSASARSLPVLTSLYCDCGLRRSGLLAMVHRVANRSGEQRKEAALSEKVACLRKNVGSIPSSKSRFVKTLRVLEEHDLVVVQDDKEGGISVLPEATFHDKARCAIGKNFKQVTIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2X5</accession>
    <name>A0A9D4T2X5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2X5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="7519" checksum="CA5F5D29182A9041" modified="2023-05-03" version="1">MLSPKVQACVGTKARRRVVWNVAQHSSGPGHGSAEPEHADARSAQEPGHKSSVAAHLVGNVGPAQAAQASAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T338</accession>
    <name>A0A9D4T338_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-galactosidase</fullName>
            <ecNumber evidence="7">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_007634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T338"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033181"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="9">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="10">
        <location>
            <begin position="380"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="11">
        <location>
            <begin position="526"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7968309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="623" mass="70366" checksum="689C20BA6D599A36" modified="2023-05-03" version="1">MKARRSFVIDYENDRFLKDGEPIQVVAGAIHYFRTLPQLWDNRLTTIKTAGLNAIQTYVEWSSHEPEEGQFAGAQELVHFLNLAQSHDLLVLLRIGPYICAERDLGGLPYWLLSRNASIRLRTADPEYTKPVEKYFSWLLPLIRPLLYANGGPVIAVQIENEYGSYKACDFSYMAWLRDLVRHHLGRDVILYTTDGAGDGFLQCGKVDGAYTTVDFGADSDPEEMFAVQRRHQERGPLMNSEFYTGWLDHWAQEHSTVSTEAVATALDRILSMNASVTMYMFHGGTSFGYKAGANVDKVNGFQPTPTSYDYDAPMTEAGDPTDKFHAIRDVIAKYLPVPHVPVPEPAKKMALGRLPLTKLYDLKDVRELLVHYRIPSELPLSFERIRQSQALVLYETWVTFLPRDPAVLSARGLRDRGYVYVDDVYQGIISRMDNVYSVMIPVTKGQRLTILVESQGRVGFVDLNDPKGLGRNVTLSGITLTDWNITAINEKDHLTARRRIDDGVKSWTPVNQSVPSCDVSPPGLAVYQATFRFDVSPPLDTYLRLDHWKKGTVLLNGFNLGRYWTPMGPQRALYVPAVLFREENLLDIIELEQAPCGQESSDCYVEFVDEPDINGPVPLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T446</accession>
    <name>A0A9D4T446_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T446"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058168"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="215" mass="24008" checksum="A536053E13311A0D" modified="2023-05-03" version="1">MTPSKVAAGFFEWTRPVPREQWDPRDPGLLQAAKPYEQVEQLIGYNFRDKGFLLVAFTHGSLPASQRIVKATMEPMDELGDALLKYFLAAKLYGCIEPLCPRSLHEARSHVVANYSFGLAVVRHGWHRLLRTGSARLNDDIVKYVRSVENADYPGDPANVPPKVLANAFGALCGAVYLDSNLDMANSWHTVYPLLRPHIDYEVAAVAAKSALYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T510</accession>
    <name>A0A9D4T510_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T510"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13965" checksum="F0DDAEE0D0627D91" modified="2023-05-03" version="1">MGMPCVEGHPTSFADTCSSVVRRGTRGGFDGRSLTPWFSKRGAMFTYEDRSSIAAKVKGCLHVFRSLGEHRFGWALFDIEQELLRAEDCDLELVRPAAHGRIRTARAILDAQGRTARRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T532</accession>
    <name>A0A9D4T532_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_002529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T532"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045933"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="540"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7971760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="704" mass="79859" checksum="7FDBA1A3B489754C" modified="2023-05-03" version="1">MPLRRLEVLDLSKNKICDLDSLARFALPYLKYLKELTLEQNCLSTITKFPSRKGQIRRLIFRDNVLKNITPGAFQQLEELTTIDLGNNSITNLNDSYFAYHSVLESIDLSMNKLTTVSRLFNTTRWIQVINLSFNSIVNISVSFRGLTELRELYLKNNAISSIPDETFQDNVRLIHIDLTSNHIGWVGRNAFKGLLTLKEFGSNVALTAIRLEENNITDVKRAFIGATRLRSLNLAGNQVGVLRRSDFAVEMSNCAAVTIRNNPLVCDCRMAWLMEDDSEIQATGFATCAEPLWLKGKYLGQLADEDFLRWEGECEPGCQCECHEGLLGGRKIRANCSSATVGKIPRVFPEGTTRLDLSGNQLRHLDDTIKRAAPHLQVLSLKDNALQSINVASIPDTVKSLDLRGNKLKRLPFSLVTQLSLTSIWLSGNQYTCDCADYSFRQWIHAHQNVVRDARDVMCRKCANLLVSRKQFVTLGQNDLCPAAIPRGVVYLLLAFGILVFLLALSAAYLRYKHVLRTWLRGHGISGLACCVLEDDTEKLFDVFVSFSSKDIDWIHGEIIPALDTMNFSYCTYERNFKGGYLLQDIIRDAVACSRRTLLVLTENFLASEWCRLEFRLAHQRALQDNINRLVIVLLDELHPSELDEDLRLYVRSANYLRWGEPNFWDRLLHSLATRGAQRKLIVKGEQRLTQLTDNTTGAIELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5T5</accession>
    <name>A0A9D4T5T5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5T5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040084"/>
    <dbReference type="OMA" id="WEAYLHH"/>
    <dbReference type="OrthoDB" id="6482703at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="24320" checksum="4E865A9D1F21A409" modified="2023-05-03" version="1">MSSYFASTMSFLLDMAIQYCVFLPLDLWTKHAIRTHGSLAERLHIWRSEAQIMAVLSLLLGLWWMRVPWLLLVLAACAYSSGRGWSPSLALEAAASRVFALWFQCMECIGVAVDGGLRKVLPQQWKMEQAATVVLTTTRRVAITSLLLTVGFLQRLWRALVHWRRELWEAYLHHSDTISVPAEARGSPPRIARRATFSGVVDRVEVTDRTPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6C0</accession>
    <name>A0A9D4T6C0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_021784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6C0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030986"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7973125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="545" mass="60618" checksum="F5A6C584712F3A5A" modified="2023-05-03" version="1">MEIVEGEEISQDEACSPGWMTAYGRKNSKGMRTASTTSERDPTLDGRKDGGRTAAPRNAYQRIVATSRLPQLPRDTYRIIVRPRDGLNVTKVSQIRFEQALAMAAALAPAEIEEDTICPNGTQNIYVVCTPHEKNACAYVKAQQVRLGECTYRVSVYPAPFDDTCKGVIKGVDVDISEDQLRERIVNHRNPGAIEVKRIKNTTAVVVLFKGMKVPNYVSCGASMFRCTLYRRHTEVCYGCGGLGHRADVCPNPNSKWCRTCGQKSPTEDHNCTPKCSLCGGPHPTADRACKKRFQVPYIVRRRRRQRHRRSEKTQMARGMQSRDSSVSSSLSSAPRRGRSVTPAAQRRNAMQSRSRSSGRSASKRRFQEELTWADRVKKTPKPKKVARSASPQHGEKSEIEQLRQEIASLKAELRKQKAAQGISSRVEGANVADNTVHKSTQEPKVEVSKAKRKAPPPKEYESDSEMPGVESSQNKMLEELLRISKENQSSINQLALRMGALESKVEAIENKVVALENKMAIKAKPKVRTQAAANDDTGVTPQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6G3</accession>
    <name>A0A9D4T6G3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6G3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7973245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11365" checksum="EA4E636931ABA3F3" modified="2023-05-03" version="1">MSIETLITSLANHANIRGLPLAGLEEVKVMAYADFSLFVRDARSLQEFQTTFEAYAQVSGAAINKAKSKALLFGSFPTDIIGDIQTVNTVKVLGVYFSCEGVAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6J6</accession>
    <name>A0A9D4T6J6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_024143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6J6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039158"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039345139" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7973335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="195" mass="21488" checksum="E5F2F62F8FF2990C" modified="2023-05-03" version="1">MKTYIFLAILGSVFAIISPYPHVEPFGGIEDSFISAARNFDKECRPAKDHGFCKALISMWWFNAESGKCEQFYYGGCGGNGNKYETEEQCMENCGAEKPILRPYPRALSFRGMTKDYRPGSGSFGGSVCQRPRYTGPCKAAFRRFYYDAATSSCRQFVYGGCQSNGNNFASHAACMAACAPSSPVRPVMPSPRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6J8</accession>
    <name>A0A9D4T6J8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6J8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="18571" checksum="ADE455724C67C8CE" modified="2023-05-03" version="1">MGSQQHQPSGGPAGSPYGGYSPQVGPSQTPPQQRPPSQPSPASTPHPSSPYPGHKMAAQSSYPATPYQAAGSPGFPGAPPAGAAGAAPPAAAYPATTSASAGYAQYSQGYPQGYGVAYGYGPSGGYPQGGAYLGAYPQGGTAAPLRYPAGYPGYGHYRAPQPAGQQAAAYGAYEQQGYPPGAYSQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8D2</accession>
    <name>A0A9D4T8D2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8D2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="131" mass="14847" checksum="1C94F65F0A7FE1F6" modified="2023-05-03" version="1">MASTWELLELAERMGLEGPEFRAWYEERMAREREERAAERKAMKEKLRAKIEQLEVQRRALERRLEVARGGSWRRHHRGSSAEMHGSKAAAAAEEEKLSPKRDIGLRPSAVMANAGGSEEGECHADSFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBM5</accession>
    <name>A0A9D4TBM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035799"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9660" checksum="375931B2421064E9" modified="2023-05-03" version="1">MKVWAGRDEPIVGFRCPDKVTGPGAKFYPYPRYPHPADCTRLITCVNDKPRLISCGYGKAFSHYSYTCEDAANVPDWYVFCCMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBZ0</accession>
    <name>A0A9D4TBZ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBZ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041622"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="894"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="983" mass="104275" checksum="485F066C6B7E7A1F" modified="2023-05-03" version="1">MGRRFTLCNLRDEIFQRRMPLKAPEAAGGSHEMSSLLHSSLKAFMAELVRAPSPDSACEQDEPWSPLAGGKQGASTEASGDDTQSECSDASNQASTSSASANRSSPTSANDEYAGAEIRASQRRVPPPSRSSAPVSQDSDGDSGIDGSVERFSQRVGSTSSADTEPSSCNDGPVERHELHESPTPSGGNDGGARSSFVAGPPRVHFDEGLAFSEQHMRRSCRQLMAALYASSSTQGAQLDPRSAGRYRSFSLPVRAFEEDESFKRLSVPAARTLPSSFDLDGRSASSGAKLSVAPTHDDVSASAMKWSGSRRSSVPPDSSPALSPTDSKDSRRLDHDVPAPAPSESSTNKHPAYCISATFKCSKGIVPSLKDAAGPVNSQYPARAISSSAQYANETVFVNGNVGQSSHVRQEHHPPGGTSRDSACESPSRDRGMTNNMCSGEARISEPWRTTYNLRTAQPVRTAPREAVVSRVQPTRPVSSHSTSSLSGPKPKTTLPPKALPLSLPAGMPPKSSSRGSSGPDTGTMRVLFARPAAVVPEPASHAEQPPTSAARSPSARRSFLSAARPCTPTPPAAHGASRANGVGASLLPGRAKNQSSDDLGREKSPLCGPREAPSCFAAEGASLTTSPKSTSLPTLVHQGVTPNGRVIAWYSFDFAYGHTEREGARQRRSDVTSSAGPAKVVKGGVEYAVVTRKPSYHHAVLSPIPRITSSPCVMDDAEPPLPPRKSMHKSDFGLYYGPASSTSSLNGGTATPNGSASHGGSTTRLLHRVQGIGRSARSALLRAFSTERIYRPQKTETAAVARDRRREFLDSNLGVNQAAPLASPSPSPSTSSTTSLVMGLKARMSLRKSKRRARQEATGIQINAESDPLWTGGHPTHVSAQLLQQNLDGTQVVELRRPPGRSFGFFLARGRVQAHHGVFVSRMPDAHTQQVLQGLLDIGDEILEVNGTDVRDADIMTVNSLMTNQSTLLLTVLPYICRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCM5</accession>
    <name>A0A9D4TCM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001040">
        <property type="protein sequence ID" value="KAH7985225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033038"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056727"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7985225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="426" mass="45125" checksum="33659EB4748FBAD9" modified="2023-05-03" version="1">MSTLESKIVELKKQIHHLTILATYKEKELACISSLRTAKEDALKQLESKYPGICSVISAFGTESGSGESSDSPGFTDVPSIVAQAATATADLTSRGVSLPTETDSHLLKKPAVQSQQQTQHSPALPIPLLAGTPAPHRLRANSASERDSPGRGLMPYDRNGAASGGLFGVYGALLSLTSWRRQRPPRPVPSAAVSQRANAFCDSECRCSGCSTPTSRGLSSMVSPSAAAAAAAVSSWWNAPNARALREYASSSSTAALLKAASVPSSLTKSHSSAAGSISSLSSQRYVKNRSHRRLAEAAAASRPEDTRDVAAELADKQEEFNLALGMYNQAMAYSLYQQLRAQGGRASAGRGANMQAGLPTELLSLQPKLSAPEMSWLQAGLVCVNCGDPRVKFVCSCCRTQTFCSEQCQAKLWSKLKTQPSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE26</accession>
    <name>A0A9D4TE26_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING finger protein 141</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000225">
        <property type="protein sequence ID" value="KAH7986894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE26"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044187"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16545">
        <property type="entry name" value="RING-HC_RNF141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043400">
        <property type="entry name" value="RING-HC_RNF141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7986894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="238" mass="26519" checksum="1AE87E27401271E6" modified="2023-05-03" version="1">MCKRCKCQAAWAYYIDYSTSSFLVISSTAAMGSHLSSEVMGAFRQSQVFGEITTLTFERLMAKVKELNDICQCLTDTKNRHLVFEVCGTSETPVLWKSEVRILCRKVGAGDGEARLLTLRQFLHTYHTIKAYCSAAASSGTANMCASTLFSGVLGTELEECCICMEHRPEVTLPCTHSYCLHCIEQWNVSNTTCPLCREEFESTKETWVISEAPESSEVLSEMQKALSKLPEQKSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YMK7</accession>
    <name>A0A9D4YMK7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YMK7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="186" mass="20017" checksum="27640AEC87E695D4" modified="2023-05-03" version="1">MHYFSTSWDSVTSETVSNCFRKCGFRRQLASEDTECSEDDPVACASDTDDDIDEEFLSTGADAPFAELVSIDDNVPTCEPQSVAEIVAEVVGDNAAKEVGDEAPEDSGENESVSRPANFVEALAGLEALQSFFCTKNNENADKALQCVQKELFLSKGQHSGFSLPFNQCWKNHCSIAAAALSPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQR5</accession>
    <name>A0A9D4YQR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_019177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQR5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051849"/>
    <dbReference type="OMA" id="KQHLDMQ"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000450">
        <property type="entry name" value="Homeobox protein notochord"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7984315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17471" checksum="90929A7A8F448E80" modified="2023-05-03" version="1">MHSETPATTALPPAPSDQGPLSAGLTPRGAAFSIEALLGLGPASPDSSTPAPSSCSESCVGAEGRRRPDTCNGGGGGRRQGSEPRPKRVRTIFSAEQLERLEAEFQQQQYMVGPERLYLAASLRLTEAQVKVWFQNRRIKWRKQHLDMQRIAHAASKLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRD6</accession>
    <name>A0A9D4YRD6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001034">
        <property type="protein sequence ID" value="KAH7985235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046314"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7985235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="16989" checksum="773133606C91C4F1" modified="2023-05-03" version="1">MKQLELFFVCFSSARMTASSHKVPEKYETLDVLVNKEAQRVGVEAIQLGGVLRAIEHGLRATAQYQQGAESQGQQYFFDKIFKAKGELVKGIGKVVEGAAKGVSNAVNALTFSDTKGVVTTKAADILRKLVIKDLSLLLAKTARHTTTFANIMPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P8V2</accession>
    <name>A0A9D4P8V2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001794">
        <property type="protein sequence ID" value="KAH7932011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P8V2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036146"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38534" checksum="FD43FF19C5548338" modified="2023-05-03" version="1">MDSAACADYLVVSQILDYVPVSDLFNTSEVCRLWQVISLGLLRRKLRYLCYCHIKSEEKCPTTTSGLPKFLEDFCRDLRRFIQIAQRAGCSPTFGFLSYSSNPKDEKAVVQQVQSQLSPRCVVVYHRSKTITMRPRDDPTKACGVHRGITGAFLFSPSKSCPATVARDAPAPQYRRQCNFKRSRLEKLSKLLRRAVLRRPVEDPCLRNVAPGVMLFHSLRIPMEDGRSLTTHWKEQHTGRVVAPTQQFSSRVQPMPQQQQHSQQSPRQHSRQYSTQPNSMEDTQELQALVELFPQVPVMSISGEFLRDEELLLLGEPLAKRKVIIMVLQLLPPAPKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBJ8</accession>
    <name>A0A9D4PBJ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBJ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032560"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="26230" checksum="51BBA66C049846EB" modified="2023-05-03" version="1">MASLSRNSESTSMSDITDGSQYRASRNKVGMAAHDLTVTVNTDGSPVFKSSKYSIWPVQITLDQLPPLLRWKNVMMPLLWYGNEHPNMTLLLEAFVVQLQKLNAKGISWTFNNTQICSKVYCICCCADSPARAAMQHMIQFNGYYGCSWRYHPGNNIDGQARKLRSQTLLRVVIQYVDDTADDRECYQWDAVSCRVRATPTNPANTSRLPLPRFKPSTTAAEADMRKMDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBR0</accession>
    <name>A0A9D4PBR0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001881">
        <property type="protein sequence ID" value="KAH7931907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBR0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052677"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="233" mass="25293" checksum="0BD95BD26E97BCA3" modified="2023-05-03" version="1">MQSREASGAGKYRDVMTDAVMPDDGYRDLTEDAPTQSSAVSAPSVAGAHCSRLREIAVQIPRRRAFRRLSSRIRKAPIVNDEDGHSPSSSSSPPPKRDEREETRQKTVIVPPEDVLLPCPLSPDVTSPFERPDGISDVTVQVIGHHGPAARLVPWLNAQTVVYCEPCLHRFPTAAQAHVVARSVNATAHDAASGRRRPTTVFGTFAECFAGGPAFRTAAVGIRARAIRGFSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBT0</accession>
    <name>A0A9D4PBT0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_024413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001377">
        <property type="protein sequence ID" value="KAH7932529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBT0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056632"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7932529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="727" mass="80907" checksum="D77A07257018127D" modified="2023-05-03" version="1">MPVVSGRRMGRTNHVLVSMLGDCLPRWILYHGVYIRLYPFYPRVEACFNCRKVGHRTDVCPHPKRNRCSRCGQDHPPTPQGTQPTCLARGIVCNGGHATNSSNCKYRFIKKPIPSDNAPKQAHNQEPPQQQPSILRTSRPPSQERRFNSSSSPLPCSPNSSQGSSPSSSTPGPKKLAWAQGPPESLKASPTSSPDAQVRELVRENSSLKAQLSSQQSQISKLMSQIGNLTQYIQSLEEKLDRTIAQPPATAPQPMEATSPPSQPQSQPAGKRKANTSAASLHAEIDIAAAVSKAVSAALTTLDAKFEARFQHSATGYCGHEQLIERPQELYGGHQYFTKHPQKLHGGHDSRNQRSPPAPPAFAHVRPTCHAAGGPQTRNGLIMARPTLTVWQWNCRGYRKKRSHLQQLVQKLQADPQATEPAPDVIALQETSTPSTLPGYATYHQLGSHASLCTSTLVHNGLTAVQHEIEATGIQHTLVEILPRKRRQVAVRPECVQFPTETIALVGDAQLLLLGDINARHPDWGYVHTDPKGRKLWSLVQDLRLNLLNDPQQPPTRIGNSVCRDTSPDLTLCKNVTRATWDNTGLLAGSDQNILAITIETRLSKKPKATARITEWPKFRKLREERASDTITDINEWITSLQEHVQATTREVETTADLHTTDSRLLHMWDAHAGLLRRWRRQRQNKKLRRRLETLAREIENHSLALARQQWGQLCDGLNGQMSSKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCR3</accession>
    <name>A0A9D4PCR3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043450"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="26042" checksum="A882F28AD925A8EE" modified="2023-05-03" version="1">MAYSVVNDVLLLETLSCAEIDDMLVLQCAPVLRRNLLERGLLDLDAMDSDVFHRLFRFRKMDLPDLLSSLLIPEEFVSAQRVRVPGNEALCMTLRRLSYPNRLCELELLFNRHSSVISSVVSTVLAHMEYHFNHLLADLTKHRWLNLIALENFSEAVEWGFGKVASEFAFVDFHKNQKMSRQRIGRMYRMATLLANCHTCLYGSLVCDYFGVDPPSLDEYLMPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEG4</accession>
    <name>A0A9D4PEG4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEG4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="156" mass="16901" checksum="783EA15F876D3D37" modified="2023-05-03" version="1">MAVTAERSVVPVAGALGSSRVQRPVPDEVLPVRSGVSVAADANIRVSRVTTVLISAKTLHEEGGKKCSGLYLPQQYLFPASISAQRNGRRVLMWKEWYGSPTVWADKQSSEEDGVVEVHKLGPSARRLTSAPGGCSHRWCCLPPEHHNHAMPGPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEJ3</accession>
    <name>A0A9D4PEJ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_013170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEJ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043027"/>
    <dbReference type="OMA" id="PESAICM"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF107">
        <property type="entry name" value="NEUROPEPTIDES CAPA RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="53"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7939491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="445" mass="49404" checksum="E73E3524EDB94014" modified="2023-05-03" version="1">MENVAVAAVSSLEDNATIREYLELRLGPQHILLPIVIPLTVLYVVVFVSGVVGNVTVCLVIARNSHFQTPTNYYLFSLAISDLLILVFGLPNDLKLYWQQYPWRLGEALCRFRALVAEATSYASVLTIVAFTAERYVAIYHPLFLQTTSSLTRAVRIIAIIWVVSLVSAIPFAVYTRVNFVDFPVGSGRVVPESAFCALPMDTTAVSLPLLQCSTFAFFCLPMTLIAVLYLKIGMRLRSQPGPGQQGRHQRRPVHRMLVAVVIAFFVCWAPFHTQRLLVVYVSPSQWTTGLRTLNEVLYYTAGCLYYFSATINPILYSLMSVKYREAFRDALCTLSKTKQRLSAGEFDAGATVVIVGAGHSILDNTRLSTLKPYSIVQRVDTEEANVDAAADIAMRALIIQTVLRVRPNQELPLTPTKSEADDKDKSPIKEISSDKSPLPSETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEM8</accession>
    <name>A0A9D4PEM8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_004448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEM8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030986"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="554" mass="60819" checksum="87DBCEAE4BEC8B8F" modified="2023-05-03" version="1">METRGAPSSADAQESAPGPSMVLVEFSGKILDSCSTFDAVCRKKPADTGLRSAQADSAWWGEIPEVEMVEGVEIDPEEANCPGWTTAVGRNKKAQPKTPKSTVSTENHTGGNGGRRTAAPQSAMKQLVKASRLPKMPRDHIRTIVRPRGGLDVKRVCTIRLAQAMAMAAALAPDEVGEDIVCPNAAQNILVVSTPMRKNACAYAAVQQIHLKEGVYDVAAYLAASDNTCKGVVRGVDADFSDAQLRTMIVNRRNPTALEVRRIKTTTKVVVLFEGMKVPNHVMCGSGMLPCTLYRIQVDVCYSCGDLGHRADVCPNPSKKKCRGCGLASPASDHQCTPECTICGDPHLTADRKCKQRFQLPYIVRQRRRRRRRAKKSQASQGGRSRDSSVSSATGRARSQSPSARQRSLSRGRPRTRSTGRSRSRGPSRSNVRSQSRARTQEGPTWADRAKQNTDKGPKKVTHVTLSEHKEDARVTQLLQENAILRAEIEKMKADFEAFRKANFQQRQHPSSGVEEPQARPAKRRATTSQEAAEETATREGNARWNIYKSPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG21</accession>
    <name>A0A9D4PG21_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG21"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031411"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048685"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="462" mass="51440" checksum="ACB47EE303987465" modified="2023-05-03" version="1">MAFLIIQGQELGDRASSWTYCTALLAFCVLSLLTCIAFFVTFADTEVLALARAPDSLDHLTVAEPAPLYSYLCTVSEPKSNNVAHLPPDNVCDYLFYDSLYKNGRNTLDLGLASLDEGVQYFMQQVAHYTHTKFGFSFAPLAALLHRDYKKPDFYTAIDAIWNNNISHFGFLNLYREFAAAVVVKEALHVLKALHLHMKPKTSANRPSYYVLGLSLDSSTDYSVVSLMKTVFVPSLFVSIAHLSYSLRNFKDCRIFPVAMEELPPGLVRGRDYSYGHTVKESVAVLREVNKLGLSIPLAISFGFKGLYYTPKFADPVSPKPDDFELFKPCRSTASAEYDNPLTVCGQAGWTVSKSSRTLAYNSAQKRTITFLTERTIALLACDVKESNLDLAFSLAAYDVDYDDGLPCAAFGFSYPESSLTSFNRVVKMGYILNFLEKNYTSTAYNSECKGIPDLRLISPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG24</accession>
    <name>A0A9D4PG24_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG24"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17283" checksum="97A4C5400CFB1BF7" modified="2023-05-03" version="1">MVRSSILWDPYCLAYLSWEDIEALMLREKEPPRRRVYASRVSSVSNKVLYHIEKNFGCLLSNMTIHPWLKHSDLEAMSEDLDVGGFAQIKLLLLEALALDKEFVIYGDPAYPLRPLLMKPYGGAALTATQQEFNSSMSAVRQAVEWGFGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGG7</accession>
    <name>A0A9D4PGG7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGG7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12384" checksum="F68A0613D69F887C" modified="2023-05-03" version="1">MKTEALLVHPRVAARRAIRRLVLGDRPIPWSKAVTCLGLKIDHRLTWIPAVKLANFKATRVQTAVGKLLSRGQGCTPRLALQLYQGAATAVQTYALPLVQLAQHRKEQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGZ6</accession>
    <name>A0A9D4PGZ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041429"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="11070" checksum="CB69CDEB576C33C2" modified="2023-05-03" version="1">MPNRTPGDRLRPHIDDQELSCESPSKRVNQFPFEHVLTVKDLLALVCRRGCCGQERLVDADSLSSRPPWLPTTYNLQTELPHFVSYYQQRQKRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI60</accession>
    <name>A0A9D4PI60_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI60"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10207" checksum="0001C289A3C2C3A4" modified="2023-05-03" version="1">MCIGILVRGRKVYVGAATGLLRSTPECVSGRPSDRDDPGQDSATRERKTLLLKPRSVTEEQNKEAAAVPKDLSLHLRPRGSILEERDPLTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIF7</accession>
    <name>A0A9D4PIF7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIF7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053036"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="228" mass="25340" checksum="FB31117D8B276F23" modified="2023-05-03" version="1">MAGPVRRYLHSSSWDTRIAASQAVEAIISHVPQWDPPGLPKWRRKSRLFDGIEKTERTCARRLDISSSTGSLLVLDQTPIHKTQAGTNAFEEYDTDVLYVLAGCTSILQPADVYWNKPFESTLQRLWEQYMREEARTPKGNLKKPSRQHVLDFVAEAWAAVPEETVARSFKGCGISDVLDGSEDCDLHSGLADVGAVVPKERGGLQAECCGLFFATDSEESFDGFQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIW8</accession>
    <name>A0A9D4PIW8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIW8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057312"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22442" checksum="1694B269C82F808A" modified="2023-05-03" version="1">MDYLKDKEAALSMLDDVILATTGEEKLDQEVETAHDDNEKIPCAVSRAKFWLRDHERTARTQAGASEPGPSNLGSPNFGDATGQPFWDHFDATIHKNTELPRIEKIRHLLTCLTGSPKQAIKGIRLAEQNYDLAFKTLTDRSGRPDLLVNEHVDHLFTLSTVKSSSEVLKLRLLHGNVQFHVSALEGLGVSPDQYTVVLNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJA1</accession>
    <name>A0A9D4PJA1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_012032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJA1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055591"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039756123" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="346" mass="39774" checksum="1DEDBFBBFFB17EDC" modified="2023-05-03" version="1">MESTRRMQLTLAALAILAQVAWGLDAWVKFNSFSNSFEVKLGRSDANDKIAAWGPSTTPSTKLGMRSCRLCCWFSFLDIYTNEALPDDHQAYAAGFLEGYFTRDLIRMHYNNTWADYCKDEGAYCKRLFSFLQENLQFMFKNVIMYHKHVPYWHQVYLVLQQLNGMEDGRVADSRHYFSSEFHINVTTTLLLNLHGDVQDLERVLKRRVLSRAVGEGSCSALVKLLPGNKDLYFAHNTWTKYSSMLRILKKFRLPYRHTPDSCANIAGHTTTFSSYPGRIFSGDDFYLISSGLATMETTLGNENDDLYRTVKPQSVLAFIRNLVANRLAENGHEWTEIFSWYNSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJM8</accession>
    <name>A0A9D4PJM8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJM8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049077"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="18423" checksum="E5028AFC7D09F246" modified="2023-05-03" version="1">MPRALLALPGLLEWRECTRLIDRSTDVVWNCVLPELRRQVPKRNTVAGNPVHCVGNAELSEAAQQVLSCGPKFAMAPRQTRQEQLAMVRQVAGKAPESEFDLAEVLLKGSRSGSAAASGGNDARFRPEKVLVIPYVHTVSHNLRKLGRKVGVDVLFSAPPDFASKCAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJY6</accession>
    <name>A0A9D4PJY6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJY6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056541"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="277" mass="31404" checksum="76F020D162EF6049" modified="2023-05-03" version="1">MHWQIGAHRVVVATRCNWFKKALLSGMRESIDRKITVHDTHPEVFQLFLEYLYRGCLDSRQLTTEQLVELMQLGDRYEVDLLKQIAEDALRDHLDEDSALFLLNLADQLNARNLRNSALEFVAINKDVVKSDGYSELPDDLQTEIMETITWFELRSSQRSEDVIPFGCQFEPASPSSASSSLLDIDEFASALSISGKETDATQVSCRVRQRSRSREPRTQALEFAGELPLTQDSAQLEVCVEQLRDVVGEAVPREALVQVSLAADYDVNRALNFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKN9</accession>
    <name>A0A9D4PKN9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_020623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKN9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027553"/>
    <dbReference type="OMA" id="PPIGCHA"/>
    <dbReference type="OrthoDB" id="6493845at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="191" mass="21010" checksum="620918518A9C8AB5" modified="2023-05-03" version="1">MAAAAGRGETAAETYSYDRNAGDGHGPLRGAALPASSCPVSTVALARIRRELEEIRYSPLTNCSAGPISSCDLFKWTATIVGPEETPYEGGVFLLDVTFPEDYPFNPPMVKFTTKIYHINIVADQVICLDILKTHWTPALTVSDVLLSLWCLLKEPYADDPADQKVAAVYKENRTLYESTARKWTAEHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLY3</accession>
    <name>A0A9D4PLY3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLY3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049649"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12172" checksum="68D004668A7E7E8C" modified="2023-05-03" version="1">MKIIIQCQESHAVEVTGDETVAFLKSYLHTTEGIVPEDQRLYAEGGKPLNDGDLLSACLTDGALVNAVVPLVGALVELLEMQFFESKLGTFHLAKEDEDPVVQIEGGFSQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM80</accession>
    <name>A0A9D4PM80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM80"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18742" checksum="8A5B1FC28AF7806D" modified="2023-05-03" version="1">MGILYSGCDPLRQRKIPTKKVLPIVRNQQEKTEDKISGLSATSASERKLRTLATAGFAAGSAQDSCDVDVDGAEELMPVALRDTLRGDIIAQVAGAQPVAEEPEGEEDEDDEAPVRPSASAVMEALNVARLFFSFEEGEEDSLRRVRALEQRAAAVAFREKKQMVITDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN17</accession>
    <name>A0A9D4PN17_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN17"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026790"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7944616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="207" mass="22909" checksum="ECB4F28709E6FFB6" modified="2023-05-03" version="1">MWIYLCNARHRCNLYKKKFEVCYRCSELGHRADVCASTVIKCRGCAIPDPPSDHVCVPTCRLCGKQHITGDSRCKEIYRTPYIIKRRQWEALQQEEVSKQQDQATQRRVALKRSSRWDRQRSGSTQRKHRDRSASFPPLEADSSHKSSRPSSSSRAPTSATTPPGLPAGKPHGSTVPGTPSAAPPATAGMAATAPRVGVPSNHVDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNG8</accession>
    <name>A0A9D4PNG8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNG8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23616" checksum="92D0885D33CA862D" modified="2023-05-03" version="1">MTEKDIYGLCDHVKNLPYGQLMALCQGFFPGMPQNALSQVDMVPTVEAWLRAIRTPQERLPHVAGLYSRLASLDALKPWTLYCVDMAWTKTSRFAFLDHVAKSMNSDGCAYTCGYAETTSCLCCSILMSDDGIMTEEHRLVCFNLWSEHPFVAVYDAGAMVAHAKRLQAGLAAMGVDPERCLHGYYEKLSSAHAEVEKTVLARKQVADLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPV0</accession>
    <name>A0A9D4PPV0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030108"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81885" checksum="4859D5A465112FE9" modified="2023-05-03" version="1">MAPQDEGLWTYSTHLVEICPSIFHSTQDTYARLQQIKHILANKGADFMVPCGKENNRDCDLLKHLSAWNDIASAIKVEISELVATRELALCFSVKTSNQREMEGRIQRAVLLLHWLLIKHTCVTTIELEDLTQFNDPECFTLFCDGIRNCRRLRVFNASADIGEASYYRQLLTACKSSRHLQMLHFQRISDAENLGNMAILADVIARNPNLVVFHVDEFSATPGDTSAVLQALQRCQSLSHLSLEVTSFNADEARVLLEMLNGNNVLKSLHIEGKTLPRHIRVNSVASALSSATALVELELVGFRMQTRDASILAMSLVHAQTVQNLVLIDCVPLFSSTYEHNSAEANYALGRNSSPIDPYLYILQGLRCLRSLAFDLLRFTSADQRAFLEVLAGNESLKYVFFDVPYVGYPKELFRIATQTGTASRLCCKPIAMDATDFANLPMGFCVEEVVLNVHANACNNNMPTVNARFADPRTLDHVTDMTVCIAGGIIDPSTAKLLALYLQNSKRLNTLTLDFSAKKESNLLLLDAISRNTSITTLGVEKWCLSKRSATVLADIVHSSRMIHTLTYNQESRVPAKAFFSRLSDSIGSNCTLVSVNTFERQRNAKSWALIQNVVMRNAVFLIRAARFVAKLSSCKGDAEVLELVASSPLLPLRVQLLASVDECEAARAIRQATWNLRDLDGFMRITGVVRESVVCEESSDCRPRLDTLPADCWLAIRQYLSVADVVDNGSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR76</accession>
    <name>A0A9D4PR76_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR76"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7950884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="295" mass="32955" checksum="E4E2F9536E858E24" modified="2023-05-03" version="1">MDPCGKEQGRDCNLVKNLSGWNGILAAIKIHIKELFDTRELEVRSPEKSFDHRETTDRIQRAMLLLHWLLVKHVCVVTVEVENLGDIIQLSSAKLLAAYLQNTGCLKVATLNLRAKHDSEKVLLNSIARNTSMTILCVENWCLSQWSAQILADLVCSSKRYHSLTYNCESKVPEKAFVSRLSASIQSNYTLVSVRTYERKENSKNWAIIQNAATRNAAFLERAARLVSGLSTNIVDAEDLALVASSPLLPLRVSEMAAVSECEAAHMIRRTIRKLRDLDAVMGITAIDWDSVTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRI3</accession>
    <name>A0A9D4PRI3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRI3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036549"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08536">
        <property type="entry name" value="SAM_PNT-Mae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="14424" checksum="5E849B9286DBEA73" modified="2023-05-03" version="1">MSPSSWFGPAASSPEQQPSPASTYRGLYALTVRWQPPVPRGEAPRHRKDNSSLPKDPRQWSREDVAVWLVHVMDQHRLPAVSTDRFLMNGKALCLMTMEMFVQRVPLGGKLLYKDFQLRLSNVLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRK5</accession>
    <name>A0A9D4PRK5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRK5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031602"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="184"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="620" mass="67853" checksum="4780A20A0A4DE913" modified="2023-05-03" version="1">MLTDAGEGILNTQARVPEPSVTWWRESVPLESVLTEHRPGVRRSALGPFVLRRQDLMAVLVCQASNSNLTSPLTTSVTLDMNFRPLEVSVEAVSPTLEAGKTGWLSCRAVGSRPRSRITWLLGDQVLTGARQNESLDGNVTLSWLALRPTARHHGRMLRCRADNDLIPGSDIFAEFRLQVLFPPKLTLRLASSLRRSQLREGQDVYLECIVEANPPVSDVSWWFGDRELFTDSTGGILVNNRSLVLQKVRLNARGPYSCSAANSQGQGSSSTLFLNFQYAPVCRRGQPQVYGAASNQPVRVNCEVQSEPAPTSFHWRLGNESLTNFTSFGHTSHVTLVPRRVPQDLGKRLLCWATNDVGTQREPCAFSLVPARDPDPPRNCSLQNRTASAFAVECEPGDDGGMPPVYVLQVLDQFNRSVLHVNATDRPAWTVSGLSSGARLSLVLYAVTSKGRSALTLLRAKTLAGSQSLTEPLWPGSLSPILVALIACAVGLVAIAFLVTLLLRYRSAKERHKHVSGSEERLKEEEDRPSEAVRWKGWTEADAEHDKSTLGRPPPQEYQSKNAGHTRAVLNESVSTLVSTPVAVPAVAVPSALCTEANVDDVSECVVVPPPLKYRQTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSE6</accession>
    <name>A0A9D4PSE6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSE6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030558"/>
    <dbReference type="OrthoDB" id="6475149at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="246"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="411"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="582"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="747"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="906" mass="102248" checksum="9ECCE93486799E33" modified="2023-05-03" version="1">MTFSHRSAFNVVENLLYVRKVITLSNVEFSQSVLSALRWYLTVGLCVLLCATCSTGDPDRYSQVKETHNGTYLSQYEWRVRDMYALLQRSSVMHGVNLAGPDFYTGKPGYRVRLGLSFGRINPSNGIPYMGVWFTILRGRYDDSLEWPFQYRFNITVVDPSGSGQDAHVSMNPMTAICRLRKQFQRPTERRNDGVEGCGKSFLIPHSKLLGYVSDDSLLVRLSIFLEDKGAIPKRAKAYMRGHQLVSEFQWAVDDIDAKIKQARKGEPQPLTSDLFYINSESYLMVLQLTFHSEDEHLGLFAVVIPGEFDDSLEWPLSYSFELSIVDQSAGFLTADRKGVIDPTSGVCPLSAFTKPQFQPNTPCGFRKLVSFSALERSNFKKDGKILLRFTAILDQMPNFASVSVKDRHLVAEYVWKVPSVERKIALATSGRPSNLLSERFYTRHQGYLMQMQLKFQNYTNGSIGVFLTLLEGGYDSLAQWPFVKRFDLIIIDQQHGKRGNDVVVAVDPNNPYIKNEACVGSFWRPFGRNDACGSSSAISYDEVYNRKYIRYGSLLVKVVVYMEEIEPPNMARLVFRDDSVVAEYDWLVADIKEKVVQAKLGNAQFVDSDKFYLTNGGYRVMLRLYPEKASGYVGLYVVFTRGAYDDVLEWPFTHKYEMVIVDQKEDSAADIVHTTFAASGCPDIALQKPTQELAEWSCGESRMASHAALLNGGYVRDGAVRVRFRVFLKEYASHVASVAVRNNALVSEYLWELKDAPAKVNLLKNGGFAKVESPIFYTGNQGYALRMSLVLNRVTTPLQTLASNDDQSVLGIYFTLWKGKHDAVLRWPFPHVITLAVVDTASGRADLSKTVDPTHARCPLEAFHRPKTMRNDHACGFSAFMAVERVGDYIRDGSLVIRATIDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSS8</accession>
    <name>A0A9D4PSS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_022842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035196"/>
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        <property type="term" value="C:chromatin"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
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            <end position="215"/>
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    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="326" mass="36632" checksum="F0361CF5BE9837F5" modified="2023-05-03" version="1">MHREIQLKVLVLNALDRKLTASSCSNDGTPGTLSTDKVSVSKPERDGKTTATRSLQCGLCNKLFKRRSQLRTHLFAHARVKRYGCGVCGRKYMLKASLVIHSRTHTGERPFECASSTNLKKTHVDPHWGTTARMQQLRTEIRHKNKPRLPRTDSSGKKTVACHVCGRIFFRRDALRSHARTHTGEKPYVCHLCPATFALLGTLKKHVASHTGERPHKCDVCGQSFTSRWSLRRHRSVHSGIKKFSCQSCSRKFGSKHNLTTHTRTHTGEKPYLCHLCPAAFVQSSNLKNHVLTHTGERPHGCDVCGKSSTQSGHLSRHKRTHSASR</sequence>
</entry>
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    <name>A0A9D4PSX8_RHISA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
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            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSX8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15010" checksum="73AEB04E3B2A830B" modified="2023-05-03" version="1">MGSSGWILDTTVAARALSTTCCRKSPFERVVLSLRNMSQLTVEQGRLLRTCSKDEVCSGSAPSTTAVTSQGEVVSIQVPTEKKVAAHANGKWKQAGSVPRFVRPHVEARHTVAAGAQSHCHSTAFERATREALNTNYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTC9</accession>
    <name>A0A9D4PTC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxypeptidase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031676"/>
    <dbReference type="OMA" id="GCSTVCC"/>
    <dbReference type="OrthoDB" id="6492427at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.10">
        <property type="entry name" value="Anthopleurin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.50">
        <property type="entry name" value="Carboxypeptidase inhibitor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019509">
        <property type="entry name" value="Carboxypeptidase_inhibitor_I68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023355">
        <property type="entry name" value="Myo_ane_neurotoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10468">
        <property type="entry name" value="Inhibitor_I68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57392">
        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038548770" description="Carboxypeptidase inhibitor" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10279" checksum="67911B22796AD6E1" modified="2023-05-03" version="1">MAATLPVFAVVFFALVLASSQANECVSKGFGCLPPSDCPQEARLSYGGCSTVCCDLSKLTGCKSKGGECNPLGRQCKELQGERASCPKDQKCCIWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTY4</accession>
    <name>A0A9D4PTY4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTY4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="209" mass="23212" checksum="BA3C979742EAC081" modified="2023-05-03" version="1">MKRCRGCGSAEPPADHRCEPKCLLCGRDHPTGDRKCKARFKTPYLVKKRQWERKLQKNAWSEQRRKENEKRVDDTTALNDRREHRSRSRSRSRSRTRKQSDSSQPRDSSGSRSRSESTSRTGNTPMQKEGGQAGSGHPGPFEVSWADTVSGGRAKVEAAPSNANTETNRDTFVRLLGGPAGRGGDHKDERAAFPTLAPSQGPRPCASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUA4</accession>
    <name>A0A9D4PUA4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 3 N-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUA4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039375"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 3 N-terminal TPR repeats" evidence="2">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="155" mass="17697" checksum="75431BD899B7AAA9" modified="2023-05-03" version="1">MVTEQPDVEMKNVDSPAVAEQDAVKADPDTLTIEDIKEQARHIEKAVTSKEPRFILRILRALMPTRKRLNDRVLRKIVTGFFTHSSQDREALLGCLEEPMETEGVVKESRIRSSKTSHLPLLPELDVYIHLLVLVYLIDAQRYEKLCQLCGRVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWJ4</accession>
    <name>A0A9D4PWJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030180"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="2">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="591" mass="65410" checksum="972FBA35D4A78B26" modified="2023-05-03" version="1">MNAHQMSQQLGVNAQFVSRITGTVYIQMNSREAESASLVNVGLHLKFNKTSEEIPGYSKRTNDTWLYSTKCLQVLKEYLAKYLDFVQRILPFLGQDKISVEDLYPKGVGKEEVKEVAKWIKEQECTKVPRVKSGALLLDEGVVQAIEETINRAKSTEPPQEVLLDVHPKHLYRPGLQHGWVPPDAKATYHLFDRVVNVRENISVPLGYRGTIIGLLPLEDNEPQMCEVVFDEPFAGGLPLRCSEHHGYRISTLFLVNLSYGSRGQRSQQLYQVPARRQQQADSYSAVAGNKVRTGSAQPRATHASVDNGWQDLSPQRRQGKNRFHHSPNSPFEAQKSSPAPESSGENTSDFASLWLGLQKATAAPMACTLPPAQQASTSSQHQGTPLSLDELFKGARNLKEENSGTVAPSSASILEDLVKRTKESMGAEPEHFCIGMDGQKKMPASQLVQPTPIAVQPQRPNLPLPFGNPPPPLCGAGSLGAQFRMPPPCEASLIPDSFVESNRRLMETLNSMPSEQQTQQPGHGLSWQMPRMPPPFNRAPLYMATSPGKEPYQQRPFFPSPRNIFAPRPTMFLVSLSKGPQSKSGFSCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX87</accession>
    <name>A0A9D4PX87_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neprilysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_012835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048524"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="163"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7956837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="40258" checksum="DF24D22202B47C31" modified="2023-05-03" version="1">MDYAGLQQTDESTINLTIENDSNYMRRLFDLLNKTSPRTLANYLSWRFVMAYMPYLDVHFRRLYQDFRRRVGLLIDEIKKTYVETFPRQSFLDEKTKELCREKVAAMGQKVGFPKFILDPVELDKEYHDLEIDDDHFLVNILKVRRFEFARDFSKITKPVDKEKYLNFGTIGVVIGHEITHGFAGFGKKFDKHGNYTNWWPDDALEHLRQRATCFVEQFSQFPLWNSGLYVNGNMTLEENICDSTAVKQAYYAYKNWAAKHGQEPRLPGLGLTNEQVFFVQYAQIWCEVVSDEGYKKYETETHSPGKYRSNGALQNFDEFAKAFHCPRGSYMNPEKKCTLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXH1</accession>
    <name>A0A9D4PXH1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040448"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="286" mass="31353" checksum="7C12847285242183" modified="2023-05-03" version="1">MLKDIKAQRNNKHYLRKVKNSLALGDDYISRFLRTNGALEQLLSVTLRSVESSCQLEALACFTNLACGDHKATFRVLRCAGPYLITFLNGSNPFLQARSSIYPQVIDMAVLALQAYAQSPADIIQDLVTRGLLKHLLPLFDRDSAKPDFIGQLGWITFYAYSNDSVQVEDMDCTARLCHTVANKMVHYSLAPQENSAALASLLVCLATWSSRSCDLASALAGMAGMVAALGRLLEAPYLHLRREALWLMHCLSGPLAQYDLADISAAINGIVPLLTPGAEYITEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXJ6</accession>
    <name>A0A9D4PXJ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXJ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050458"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13150" checksum="50B19229743EFC61" modified="2023-05-03" version="1">MAEKSTLAVYRCHKIIMMPEMCRCRVCEKEDETIEHVVLRCEAIDPAVANGAPQETALGFKQAIGDDGRCGVDRATVAATKERLECWRAACSESYTIASSQLKKGILSCKDAIGVYAFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY26</accession>
    <name>A0A9D4PY26_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY26"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036836"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051867"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039313817" description="Acyltransferase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42565" checksum="871F66E8773635DB" modified="2023-05-03" version="1">MPSIPLHAVGFGQASVKGLMIAVLFLLASTQLAQTSPARNGTADSSIVDIRETAMSITVSTASPEDEGRIDYAQLLRDLMPRVLSSIPASLWRRLLEADVRPECTEGLLRTLRGFRNLEPWVLRRALFEFVTAFSATSNTRVLLKVADKAKPDDYALQFLHGIRFFSIVYIVMGHCSSTVSDTWCDGFFLCFTVAKQERNGPIVFIIGVTRRLISVMLRTTDEYYTRPYYHAVCYFGGCMTYMIKEDFREARISKRLQQAGWYGCVACGLFCVFVKFAWVTSFNDVPRGLTLSAAFFDRILWTVFLAWITLACSTGRGGVLTRLLSWNAYVPLSKLSFGVYLLHLPFLKILLNASRERMYWSVFNQVASGSVHFWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZI6</accession>
    <name>A0A9D4PZI6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZI6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050600"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="409"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111240" checksum="FDA671FCE3A583F9" modified="2023-05-03" version="1">MNENRSTSEPCSFSDSGEPLSATSSKWNPSSTEATSCKRGRRTPLKVRMAAAPSLYVSEVSYNDAVRSSDLLQPTECSSSSLATETTDTEYSYDQCSAYIAQVSEAEGTLSAYQQRVKMYAMQQPQQHQQQQLKQQQLKQQQGHQHQQQLAGVQPTYFDEVPEQEFPPYPYAPLVGADAQSLFGHAEPNDASRLRLAPSTSAATPRPSSAVNQPSCASDLFSYSGARSRDTREWSHSERQAPAEAVARSEVVSSVLPVTTSGQQVNVQPAASLPSASVLSRGAAAEVTDIEWPPKRQDPAVAEDWKPEALSEDVASVRVSALVGETEGGAAQEFVDVHGLRILPAHREWLLYPVAFLLLGVVIGVVAMVTVPFRTAALTFLQPSTCTSPTCAQNAIYLSHLLSWDDMNPCDDFYMFVCRRWSNKVPTASDEESLSFDDDYAATLEERMYASLRNNSRPERLNVQALSVLLDKCVDTKRIEDDWLEPSMSVWKLAGKLLRRSGTTALLDVSVSTRPSTLNQDVVMVGLPEVISTAEGVDVNELIRFYTNAAFAAVNALRKGFVPPAYTMDIAKFASELERLYEMRDAGSYRVETLVSPSPLLDFLTEALAGLPIFSGAESEVLIVSPAFVKKAIHLVEKTEPHTVINFLCVRFMIQTSAFLPSSGLTEFYSTLVYGKLRTSVPRQNLCVRVVERTLSHLFLYGSFTELDLHTSVTKFSDVVIDIVKEFLRGIDASPYFNPASRAAIRTLVSKTRFKVLGPSWVKDNNAVERYVKNFPTFQSQRPLDAYLALYEYAFVNVMLRGPSQRWPLSAFSTRCRYEISARSVYVPALLFNVSLSFDNKNVNACLFDMLLAMTNISGSTNSEDDAPEQWLNRETRLRLRQAERCFEERDDDRQSMDELRDLLAAQIAHGHFRRSVQASGKVLPLRLPRGGGDEEPVLGEDQLFFVYLVMQSCHKQSSDQKISGPHSGLEWNVVLRTYANFSDAFQCPPGAAMNPGKQCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q029</accession>
    <name>A0A9D4Q029_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q029"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="710" mass="78932" checksum="D79394710106BFAF" modified="2023-05-03" version="1">MHTATPPCRRRLIRLPAWSPSSPRGGGLLSPSQDDSRIGRSSLCGGNNRAAYLFVAIAVVAIVTLILFLWLRRSAGSPQASLTEVQLHELGVSCDREQHRLITEETHGARANACEDFYSFVCNKRHSVMRPLEQRIAALAESSDDSTRHDGHDAATATTALLYRSCLYFVSSDGLSFNKEQHANEFFDIVRTVTRGMLRRLDTPAKIVQFQAILSKERGAPTRIFFATDGHGTHFLDVRPPLSGFVDNDTLSFLLAAAAEALAVDKGNEKVDVNRLLAVDNDLQATWNSSRRVRRVSLETLASIRADLSRGDWHVAFSGSPLAFSLDYDVMVRGLENLENALEALFVRLKRDEAAVYLFTYILLPEEMLIAHVHRRRQDLCFALVRHVTGDIWYQLESTLFFPGDVTKDALSLARSLITNIERRLVSANSSDSPVNTDRATIFPRIVLAPSLVNLSSPTMRLLMWNIRPDSLYRNLLELRTHFAILYKLKFSDLVSLTEPVALADGRGGVSVTLTPRYLQAPFFCHGQPKQLNAATLGVAVVSKVLEASLDIQSCGSSGVPGKCSSTDPDSSKNDLPYKTAMSLFGTCLEEAFRDLNASDVDESSGDGFRNTLEYWTTAFQVAEDYVQMDSAADNTPWPYHRAENAVAKAFFERYCYYLCEPEDPFHPTGKTRWARHLCNAAAMSSPMFAALFDCAEGQTMAPRHRCLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q086</accession>
    <name>A0A9D4Q086_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_014456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q086"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050599"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000195">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 10" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="11">
        <location>
            <begin position="281"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7962103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="441" mass="50357" checksum="64C17343D1125A8A" modified="2023-05-03" version="1">MLILGFFSSPADEMANGRLERFIRRHFRPGFVKLITLPKREGLIRARLTGARAASGDVLVFLDSHCEATDHWLEPMVELIKKDRTTVVCPIIDLIDDKTLQYMGTSSDFYQIGGFNWKGEFIWINTPEAWRKARKSKADPMRSPTMAGGLFAIDRKYFWDSGSYDSEMEGWGGENLEMSFRIWMCGGSLVIAPCSHVGHIFRDYHPYKFPSNKDTHGINTARLAEVWMDNYKYYFYQNRPELRKISFGDISERKALRNKLQCKSFKWYLDNVYPNKFVPSEKVFAFGNARNPNTGMCLDSMSHNYDNTEPLGIYPCHKDTNSGGNQVGAISWSSLDRGYCIDHHRQKTAVAELSSEPDKSDKAARKVMMAPCGEGAESEERQRWDHTRGGPLKHRQTGLCIEAAPTDLDAVLAKPCTGGHNQVWWFLHYARPQVDVLHNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1F3</accession>
    <name>A0A9D4Q1F3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1F3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043922"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047051"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.770:FF:000002">
        <property type="entry name" value="recQ-mediated genome instability protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="130"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="540" mass="60100" checksum="CC2C163FE2E90D77" modified="2023-05-03" version="1">MNLDDRDRLTEFSRNFSESSVYASYVTAWNRVVLCYEGSASDQQGRSWSMDRQLTAIRNFFRRLFFRNKEVAAAAGQNAEHAESAADVVANHEESAASEQRTTFGGDVYKQVYYQLLLTNLWELGMTCLPESAVTAHKLMLKGSFFLQVDSVHDVSQPAYSQLLKITNTENPNTVVQADPVEKPSPWQAQPKRMLKLELTDGTRRIQAIEFEPIRSMSVDMRPGIKVLITGPVECRRGVMFLRADNVRVLGGMVESLLEGNCREALLCRVLGRDPAQVLGNAPRQLTANRPERDSEDTNNRQNSSDRTSDHPVRVPAASGSPRIGTDFHNDSRATTIPLANSNSTTVRMTSSVLDVDNVWDRADGTDMDPDDVLMSQIDLGKLEPEAGMHDFTDDDVDEDLLREQLEFQAQAAGDGILQDTARTDEHNAGSTLPTRRCLILGVPEEESAAFASDGPEKVGRPRVDGCYSCSLAIWSIWRLVSLASGLDEHPRQVLFCPAFEALRSGLHTSVAVAHMMTPKRLSRESVWPHDDAVAMCRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1R3</accession>
    <name>A0A9D4Q1R3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1R3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057938"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="27991" checksum="18C213243CB4036D" modified="2023-05-03" version="1">MRRGAAVALPAVLRHGRKTMTIERHGRQEVVSLDRVKPAHMETNQATTATSAFPPESFRTAPHPTPATDAPGGSTVVNSKCAAVQPWRCQREGERHSLSSLCAVTKARRRRGEGERENQFAEKKTQLVPRLSTTRLVSASLTHVDGRSNRHVDGRFTLLNALTDAPMNGSAPGEQIAVNCASESPNVNNGESTSASDTWPDLGQVNSMPVSSTLVGCQSGDSNTNECTVHDTRGDEDIVPDFRGSLQTWAIESQSSHAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2Q0</accession>
    <name>A0A9D4Q2Q0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_021285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2Q0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035240"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7963518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13835" checksum="F8FC592EB5322A03" modified="2023-05-03" version="1">MASDGGTGTAGTSSGTKANKRRYCCVKDCHSREGQPGIRLFRFPGQPWEKERRRKWIVAVRRVNECDGSAWIPSDAARVCSKHFVNGEKSNIAAHPGYYPTIFPDAYKSRPVDAERALSRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q366</accession>
    <name>A0A9D4Q366_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q366"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031631"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="295" mass="33437" checksum="11FB02C9A4285DC8" modified="2023-05-03" version="1">MLVEVLSSLGIDLADVQKASSEEALRAGGSVQYMLGVAPLAFVSMDSYDVKGYSRILALEDGDALMSPEDAITSGRMESVSDLACMYLQAAAPEGQRSKDLCDSIADVALQLAKLFQAMNGSRRHMGESMPVLIKNQELLIVIKTLIKTMPEHVYRYIGFHATAYLSPYLESMEAFWEMALFATARRVPRRKMPRERIGRMVDEAMLDAAVGHSPPEKWRLCLHVVDRLLPGVLVVAFARYANDTTFFTELMDFEQRLFAKRYLNEDYRLDHLNMTADQLFFVYYTLLWSLYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q523</accession>
    <name>A0A9D4Q523_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_006432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q523"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026888"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7968181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="368" mass="40921" checksum="435DE0B95753EA56" modified="2023-05-03" version="1">MFRFPANPGRRRLWLAQVKRDDWEPTSASRICSDHFKDSDYELRRQDGLKQLRPDAVPTVFPVRGVLEQPEPLEMYSSPVLPPWHAHPAATLQSTQPVSDSARAQVLAPPDFSCNPVVALSKIDPSKYQGAADTLMLAQDTLRHMKMGPTAHWKPSQAGLLISTSVVLSLAEELLSLRGYKYLLTSRLIQDCLENVFSIVRMKKPVPSAYDVKSSLKLICVGQFLYTPKSSSYDSDDGLHLADLLGASLEKSLEEFINDEEHLENLTLDEVSSVECDILAYVGGFLLKTIIKAIGECPPCTAVLLGDGQCYNALIEWKEYVKGATNLLRPSAAVMELLVHYEEHFKGFVAEDAILDLKAPFRTISSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5D7</accession>
    <name>A0A9D4Q5D7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_007173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5D7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038577"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043581">
        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7968242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7747" checksum="638E36545DC0FF6B" modified="2023-05-03" version="1">MRREACARLEPSGGDVWSLISKKGNYRYFFQRSCQEFGTDAVSEGISDDNEILPVWEGKIFAMVEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6J1</accession>
    <name>A0A9D4Q6J1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6J1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046684"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="250" mass="28960" checksum="DE784735AC7BC36A" modified="2023-05-03" version="1">MTADDEVLLKFLRARKFSADRAFKVVKNYFKVRRDNPQMLDDLSPSRIPFDSACRKHGLVTVSRSSDPLGRGAVILRFGAWNTDVCSLNDYFRVCIVHAMHLIHQEQFQVKGVVVVLDLKGLGVYHVAHYTPYNIRTFFSLVQDCFPLRIKGVYIINSPAIFELFFAIAKCFMKAKLMRRIRFIGNIDKLHGLVPDDVIPEELGGTNESYDYDVMEEDLLQEEEFFRNVNSYGYRKKSKTMFEHSVVRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6L9</accession>
    <name>A0A9D4Q6L9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_012298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6L9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034732"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7968902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="252" mass="27871" checksum="72B86A324DE82515" modified="2023-05-03" version="1">MAPSQKPKDSNHLYATSFVPNENRSRTGINAVLLGPPGCGKGTQAPKIQKAYCVCHLATGDLLRNEISSGSDLGKKLKSTIESGGLVSDEVVIDMVAKNLDKPECNNGFILDGFPRTIVQAEKLDEMLQKRRTPLDSVVEFGIDDSLLLRRITGRLTHLPSGRTYNEITNPPKKPMTDDVTGEPLVRRPDDNPEALKKRLAAYHKQTAPLVGYYQKRGIHSRVDATLTPPKVFENIKKIFDDAKSKDHVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7K8</accession>
    <name>A0A9D4Q7K8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7K8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032017"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7969650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="611" mass="67785" checksum="E80A7F3995C7E8D8" modified="2023-05-03" version="1">MQCVVEGHTISEEEWSDDSWQSPGYRAQERRRRELQNQGKPDLQLSASDNARAAVPERQHQIKPRPPPLRRRAPLPRLPQDTIHIVGRPRTPIDLTKVPPWQLHNALLKAASLPDQPPASRDRLRTHPTNNTFTLSVIDSQRAQAYLRVKSINVGTDTIELHVYAPPPDDAVRGIMFHAYDDFSDNEILADLQASNPDMPIVSGRRMGQIRHIVVALTTKNLPKWIFYHGTDIKLYPFYNRVEACFNCRKVGHRTDVCPLPRKQRCRRCGEEHPPPGEGEKPKCTSRCIVCCGAHNTGSSNCKYRFVKKAPSTPQWKQEAQEPTLNTQGNPSHSGPSSSRSPSPRDHSPSFPPPGTSSSQHKGPERRSRSQTRRVRSRSAQRRHSKSRSRSQRPTSHSARRTPSTSRSSSRRPGEAPKSLAWQRGPPASLLSSDAQVRELAKENFALKAQISAQQTQIAKLTSYIKSLEAKIDRALNFNKQTATSTPSQTQETHPNSLTTNNTASAPAPQPQNANKRKAATPTASLHAEVDITATVTTAVTAAISTLRSDLTAQLETRFNAIHQIILETNNSFAVLKSSTEAALADFSVQLAIHHTSSNSRQPPATAPITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8G1</accession>
    <name>A0A9D4Q8G1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8G1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15577" checksum="616BC30604F20C12" modified="2023-05-03" version="1">MVIVSGALQQDVVDGLARWALHTRWVSAARKPEEAFSGAAASDALTKKERSRTSVEASPRKQTRRIPRCHPRNRVQRAHLTRNDEASHIADTREGEEIQQVLRRGPKFSVEPTLRPEEKIATARTVSKLPKEEERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8Y3</accession>
    <name>A0A9D4Q8Y3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8Y3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040606"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000169">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7971887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="565" mass="63494" checksum="18A284DB6DE54203" modified="2023-05-03" version="1">MLETKERTEGSVDNRRKCVEKFLINTEVVPVASCIQEGNADSGWLRDGRPERVMLESLYWKSPSALLTTTGFPEYTSGVDGHNACVCDGCCSELAHAGSSNNPQGPRGGRGGDGAHGGAAAAMDAEGEKVLQRTSSLLQNKAFTDVTFIVGPPSASKKYVGHRVLLAMTSPVFEAMFYGDMADKSKVIRIADIAPIGFENLLRYAYTDNLKLQTVDDAMLTAYAAKKYILPHLLKDCFAFIEKHVTPQTVCQVFEFAQVMEAYPLVHQCLNIIDRQTYHVLTSSNFPNVALHTLETIVRRKYLNLYSEYALYSAVVQWGQEECSRRNLERDMDNVRGVIESVLPLVRFLAMSPEEFCKGPAKSGLLTKEECFSVFMNMAIPGIVPLPKGVSMEGAKRTSPPEHFVARRYQAVSFHAPSRPLRLFGLKFVVPTRDVFLVGVGFPVRQDLGSYSVRQPKFDGQLRCSYKVQEDRREREELDVSFTLAKDKDVRIKFKKPIFVRKALEYELELQLSSLMSDDVIVPSLKNRKKEDTVEGVTFQFSAFQRPHMSNVLEILEFSDLLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q902</accession>
    <name>A0A9D4Q902_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q902"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052923"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="17719" checksum="CE68DE618DE18217" modified="2023-05-03" version="1">MLVAHSSAIYPTLNVMTRPGMPQVKAVALLAPAGHQLVRAIRPLPLMRAFAVHYTNPRYQGFMRHLGIAIMKYTRNPIKPNIEDAIMSLQTMIFSDYEEAGDKIKQVANSGIPLLIAFSENDRAINPEVIFNMVDLIGTRNQDLWLYDADGKLVRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9E7</accession>
    <name>A0A9D4Q9E7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9E7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048709"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="613" mass="65258" checksum="E763EF089359AA29" modified="2023-05-03" version="1">MAAPNQVTGYDPESLRIVSMDTAQTEAPMPTEEEYLQDMLRVWRGKKNSAVASRDAGALAARQRTASRSQHAQGKSAPSVASQRIKQLQWRPKNTPRIEKDDIIVVLKPRETLDIKATFGPGQAGAAVRSILGADASVGLAVWPIWDQNVLVCTLKSVDAAEKLLRDITLPVGGRQLPFRGHPKLSGEFCRGVVHVSQDETSETVKSKLSAEPNVVTVRKLGDTTVAVITFAGTKVPRTVLYNCERLPVHLYKKTVPACPLCGTVGHRADTYPRPQPGRCISCGVQVPAATPDGPTEHQCVPSCLLCGGGHKTGAPGCTGRFRKPIKSGSPRGSKPKTAGGHKQPPMPKTSPKKAPATKPNKPEPKKAHTGPSTNAKPGTPSKPPVFMVKDFPPLTPVQAQVSCWGGAVSGPSPSPSPTETTLQQQIEELRRQNRFLARKIQELEAKQVGSSEPEQGAEVEDGDDGSSVTSDLTSVSRRDADTVVGSVSATGATGRLESLERKTEQLEERMAALPDQIMSAVRASFQDMFTAALTQALPEIVAQVSDSVLKAVQPWVSTQIKNTTQCDSPQLKRKTASRQAVDEDFSGLAPGGPVRPPMAAAPAPGPGRSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAE5</accession>
    <name>A0A9D4QAE5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF63">
        <property type="entry name" value="LD26477P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="378" mass="42679" checksum="AE2EE4311971F7D5" modified="2023-05-03" version="1">MVQVQYQGNRRMAEHCANNDPMSGGAGAAAGDSPGLCVSQKIHWPHNVTCYLVKFYRQTPCLWDHSHRDYSDKMAKERALQQFSNETGYPVEAVRKKLINLRNQFTNEWQKMDRSSNSAKPYRTKWAFYKSLTFLKDVVLPRKPRNALHHEGVHLRMPPMGVQAFDTRSMDMSTSFGFARERRLHDAQQFHHDGLRLDNSPQNHQNHRAVQSNNDDSSHLDGAAGAPALLDGLQHQEAHRDGSSHQTPPQQQPQDQDVTVIGAGADVDDLELSQSSNSLVLSPEVTLEEPSSSERRILPAEDDGFHQEIRQTYTFPGERYGDIQRGDHVDAFTCYIGTELRRIPDEETVGQLKLQILKLIFNAQATTAAYQGSAHAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAH6</accession>
    <name>A0A9D4QAH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAH6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="222" mass="24384" checksum="634E09C35508DBB7" modified="2023-05-03" version="1">MEVVIEGEEISKEEYNDGSWTTLEAQRRCARQLALAATASEQTENDEADTAQGNEKKAPEYRAHPPSLPKRKPLPKLPQGDYKVILRLQTAVKLLIYGAAKLFNAVCAATQVPIEDAISEDQARVHRNSNTALISTTSRARAEGYNNINILKIGQEEIEVVAYAPAPENSTKGVIYYACSDKTDEAIFKELLARNPSIEMVGATRLGTEHIVAVFAGTERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCB9</accession>
    <name>A0A9D4QCB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCB9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="245" mass="28018" checksum="923F1F07691C07B3" modified="2023-05-03" version="1">MLHAYIGGRKIRFVNRPTRLPLEPVPHVLLGDFNCVVDSTRTVRDPGRGGSTYRAKELVKILRHLKLTGVWVYLHDDTFVPTRSSRTAASKIDRTYVPDFLLPSVGSCEVPALPDNLARKTDHVPLMTTVTRTPGTRTSNTTWRRDPALLKDDTSRQDTEDFLKESIRAAAPVTPGEWDRLKAAWKAFLQQEGRVRKRRITKEMNELLRRIRIIQNADSLTACTADYLASLQSRFNRLLQDKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCS0</accession>
    <name>A0A9D4QCS0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_001779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCS0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050436"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7975450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12192" checksum="4C10960714F60E75" modified="2023-05-03" version="1">MWTARESYEGDVEVEGARPRKFQQVFGSPSVEGGPATWEKKTRRSLFLCDLCPYTTRHKTHMRDHMRVHSGEKPFKCTKCPAAFTQATNCRRHILSHSRQKTPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD30</accession>
    <name>A0A9D4QD30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047152"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="31564" checksum="A5F10FD29D6D49FC" modified="2023-05-03" version="1">MSMQFGPTAGVVSSASMLPSFGFTQEQVACVCEVLQQSGNIERLGRFLWSLPACEHLQKNESVLKAKALVAFHRGNFKELYRILESHHFSAASHPKLQALWLKAHYIEAERLRGRPLGAVGKYRIRRKFPLPRTIWDGEETSYCFKEKSRNILREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKDSVDIEAVIERLQHAACCERPGKTAGEEGSPSFPLTGAVVDRARPYGCEREACSGASETSPDVYAACNGGLADSSSSLDDCVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDG9</accession>
    <name>A0A9D4QDG9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_005014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDG9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7975772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="29845" checksum="E8125BC7A83903B8" modified="2023-05-03" version="1">MHYFSPVDKMQLLEVITHEKTSQDTAATAVAVGLKQGKVVITVKDAPGFYTTRILAAMLAEAIRLLQEGVTVKELDSLTKKFGFPVGAATLVDEVGIDVAEHIAEYLGKEFGSRFQGGNPQILKDMVAAGFLGRKSGKGCYIYKPGVKDRPINAEAESMLKNYALPKKLDNTVEELQFRLASRFINEAVLCLQEGVLANPVEGDIGAVFGLGFPPFLGGPFHFIDTYGADRLCQWMDKFTQTFGPEFQPCQLLRDHANDTAKKFHARNKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF42</accession>
    <name>A0A9D4QF42_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026560"/>
    <dbReference type="OMA" id="RVGINAW"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="457" mass="52191" checksum="2210EF39B6A57A25" modified="2023-05-03" version="1">MIHAVTAAHSLIAQQVHLFWNPVGLPEYMELRDPELRRALNGHLADDSQLWPENKIVSLQPELFYELNATHFSRANLTENFKLFLGAYVVWLFSPYASSYLTTRMLEDMGLESSAQQYQRHKCTQALEDILPLVIWESGRGDRNYKLYTWKMLQLTTLSVNQFETVYGDTFRAYFSPVMSRVGINAWNMTLKWEIIDSVYSYVPFDKTAGFLDMYVRISVRSIGILKKSLRRTSLTTLQSPGFAAVRLYSMLVARELIVPNYLRTPPLFDVRHPLPVLVALVATVICRELMVLGRFILYYDENFTPVLTNPVFGQLVSLLRDLQNYASFLESSGHYTQRDYRKLIAAGLAAHVASGITRLPEAQNFFSMAVEATNANGRRPTFRGFREEQLYFLVTCFMECGSANHDTSLQRAICNVALPTVAAFRQAFKCEPYHRLVTNFTSPEPPPSTTTRYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF61</accession>
    <name>A0A9D4QF61_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF61"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12973" checksum="409B7322B0C8E3FD" modified="2023-05-03" version="1">MPVALHDTLRGIRFADYVEVDTGASVCGALTDEDIIAQVAGAQPVVEEPEGEEDEDDEAPVRPSASAVMEALNVARLFFSFEEGEEDSLRRVRVLEQRAAAVAFREKKQMVITDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGT6</accession>
    <name>A0A9D4QGT6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_002772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGT6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="162"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7982049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="365" mass="41794" checksum="BF3A1561C6E49B19" modified="2023-05-03" version="1">MDSDSEDEEFDDVVAIVALRLTRLNRNRIPRYCEEVVSRYFDFEFKRLFRLSRETFDRLVARYMASPFFPYATRGRPRVSVEKTCLVLLCYLGGQCSMYSLADRFDIAVSTVHSFVERILGFLNSVSAEVIAWPDRQEQERSKAGFLAKSDGKGPQNTVGCIDGCHVEINKPTESPNSYYNRKKFPSIVLQGIANDRNKFLDVFIGFPGSAHDARILSESPFFGDAATKCISGYRLGDSAYPLLPWLMTPYRDNGQTFPLWKKKFNKVHSQQRVAIENAFGLLKQRFRRLYFVDAASIKQCVLIVMGACVLHNLCSEERDFFDELQHLPQQDDDDDSDVNTDIFVDRHVAGFSESLRKDIAQNQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHB4</accession>
    <name>A0A9D4QHB4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033075"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="36838" checksum="EEA12B0D0482E7FC" modified="2023-05-03" version="1">MAIRQHPRYVEIEGLRLTCEFSPEPVRQALQFVPCAGDVVLVTYPKCGTHWVQQILQLIVNRGRSAENFFEWLARTPLLELLGTRILEDASEPRLMKTHLPLARLTLRDDAKYVYVARNPWDCCVSFYHHTKALPAAYFSEGTFDDFFELFVSGQTDHGGFFDHLLPWYARRGQNNVLFITYEQLKKQQRDTVLKIARFLGPEYEKALLQDQVFFQTVLDKSSVEFMKKQFVLDSGILKGIIERDPNALPEEVKNLFGKVFVAPLKEANTVNFVRKGVVGDSKGALTREQLERMKFFIEKETAGTDVMQLWLDEDPLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIM7</accession>
    <name>A0A9D4QIM7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIM7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051522"/>
    <dbReference type="OMA" id="PMMTRKI"/>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7982822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13271" checksum="D2C8BD76BEF78436" modified="2023-05-03" version="1">MSAHSPEHKVSTSRSIPTRRIVINDASQLPHDYSSTPGGTIFSTTPGGSRIIYDRSFLMQMRNSPVARTPPKNLPVIPGVTLSSSPDVSKASGSPMKPTENGALPSPAKGAKPEGSGDEPQFAMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMW5</accession>
    <name>A0A9D4SMW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002087">
        <property type="protein sequence ID" value="KAH7931663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030363"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44940" checksum="DCE08CB3387C7F16" modified="2023-05-03" version="1">MAATQQLRPLTFYGRVPKGTTNVDICKELVKRFSPSELKCVQDFGAGRFEVTFATMAAVERFLDQSVVKVRNAEVKFEYRGVRVKTVRVLGYPADASDSALLNGLAAYGKVLGMDYEHVPEFKTVLTGNRRVRVEMARPVPNLLPVGSRIVQCEYDGVVRLCRRCFFPGHHAADCKVPQCERCAEFGHARCEAVCKRCGDDHALSACKVRTYSSVAARAPARVSSSQVTSGAAEGQEAPSKGPEGSPLPETEPVRAEAPGGGEQGTRPELAEASDPSAALPPPAASTDVPAAPADVPAVPADAPAAEEDQGETMDAEPWRLVRGKRRRARSSDSSDERPAAAACGGPGGSEEGLPGVKRTAAADSDSESTQSTVKDSTEGETSLFSSSCPYCGLGTCDGDCSPLSDRVYSSTHEDSSSDEESSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNY4</accession>
    <name>A0A9D4SNY4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038835"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045955">
        <property type="term" value="P:negative regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037658">
        <property type="entry name" value="CBARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28597">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28597:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="721" mass="77249" checksum="B11DC17342FAEA7B" modified="2023-05-03" version="1">MSSRALIDSYEFTHSVEKKLPAAPVVHAPPSGSGQMPQLPKGKPEVKCESDPKRGSKRESKTKGLKSSASSGGNSVNIGNRGSSSIAKPEASSSSKPLDAGAAAEVKKKPEVVTASTSFAAEPLPPPAAEPEVLFPTCSTGAVPKRIVVQATSSSSSSSAKRGTAHGDSHSGSKSKARWASSGRIQRQASVCIPWYEEDQWYQEPQCSYWPSPPLRRLSVPARLTPPAPLSTSPRRDLSGEGWSEVPASLRESASTENPGLLEQSLDRMARRLLLKSRSLEEEPTTGGSVVCYNDIGSKEAVDYEESLSSPGALTPESDDPSEEDAETVRMQYRQLWQLRATFEEEETTTDCFEELSAADTASHVIEGEEEDRRLLQQHRNTGFSTSQESEAADEQQTRSSGGRIPNVPSEVRRHNYQVLLARRLQRRVEKGSADNSFDSMETDCSSTDASRTEGGVTTSSFDSTTDNTDGGGGGTSGVDGQGHASRLQQMKADSGYKSMESSNGNKPAKLSRKHVPLQELHAASAGSSGGPSSSRRSALRKRRQLEGGLLQMRARSEEAPASASCSSNLGSGLTAAEAAEALQSSSLSSEPLGSLQQETQGKVSVFQRFFRSTRRTSSARSASSSNSASKRVLMRDFSIDPKTDALFREFSRRDPAYDSPRSCSSSGQGASPRLGSSKLLSPQLSIEEEEGSEDSHSAMEDDWKPQGPCCDVPIARLPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRU5</accession>
    <name>A0A9D4SRU5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRU5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="185" mass="20281" checksum="B60D9A7237C1FE40" modified="2023-05-03" version="1">MSVGFMVHSPHRAGGLSVLELSRGSEEVQVKSFERLQRLGSPIVDAVLQGTLDGFRRELKEKKGVSSGIVEATLRPVIVVDFKEKQTFIPDVVVAWDARTETLEAMCAHKRDKYASLLPVIRQRRSSCEVKVLGLAFGGRGPISPSTKQAAKEIGLWEGELAWLAARTLVGSLIGLNRFSKRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRZ1</accession>
    <name>A0A9D4SRZ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran gtpase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042725"/>
    <dbReference type="OMA" id="LRIHKMR"/>
    <dbReference type="OrthoDB" id="6494715at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="84801" checksum="74A6195C24692E81" modified="2023-05-03" version="1">MGKSLSRHCLSSRRERPPSVLSVDEDIVGPCTGTAEPDCPCVIFKKLEALNNRLRSVRLELVEVLPGQLSLSWYESPWESSKLEPAATSQYDPRKSPALGNVRAHLAAAGDDTAQVTAKEIEERTRALTLVQDVLTTHRCVIAVEVNGRTFGGHEELIRDAITSAGSSLRAFRVRDVYRVSQRLVDDLSEAVGSLSQLQELAWTHDKLQKPLSGRLLTLLRTSTLTSLDLTEVHMPFPHAEKLFGTLKKNSSLRKLTLSACLVISDPDETSGLLRDYLSGGHCDHLLSLTVRKSCTSHPPSLSAIVDGVCDNRSLQDLSVAGFFLGRWNFAVVAKLLSENQTLRRLTLIGTSWFEVFQGSFKSREHWKKRESEAPNGFPRCLRALADHRSLEQLTVDVSTFTVQQCFAFCEAVRANEALNTVTLARVRNEDVGAFCDAVRKTGTEQRIRLDHGYVLKEGCCDDVVEYPALIKNVVLDRNNFREPQMINEALRSLPRFGQVNSLSLSVVISQELFGVVASFLEATTSLRRLDLSLPTSEPGSREALLRVLARNRSIRTLRIHKMRFSDPEIQLLATTVSDSSTLCEFGFFVEDNDRVTLKAFLCALEPWFSCNYSMLELSHSPVDDCPQYLSVERVPRRNMALAVRASHYVMGVNASKRCARALELVSNGQGVVRTVAGFASVDEMTAAGLVQQALERLADMTTFMKAAGVVRQNLICHPVSGEDLRGGARLQLDRLDADSWRHVRRYIRLADILDSDFHPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSV2</accession>
    <name>A0A9D4SSV2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSV2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034848"/>
    <dbReference type="OMA" id="MIEFDKA"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47059">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47059:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15679" checksum="E5B763D89F88F32E" modified="2023-05-03" version="1">MDSATGDVPSKDEKKAQLDDLIEKKKSEYLSLLQQSQEHDPKSAEDLNQRKYELALAYNERGQMNYRMIEFDKAVEDYTEAVRYCDSLAAAYFNRGTVKYRMGYFDVALPDMEKAVSLDPTNKEFQLGLKETKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STA0</accession>
    <name>A0A9D4STA0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STA0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7948226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="195" mass="22063" checksum="240E1755928BFB0B" modified="2023-05-03" version="1">MSHGKDHDDSAVVQWKGQLDLDRPCGAVSSDEACWLCEDFPAWNTVIYAVYLELAETAPGTLRLRFEPDRFEKKDVFEAAALNFYARLNLRDVDAVIGLETLYINIDRPSQRCAAEIDALLKRNRNTLKSVEIFDCRPGRHKLRMVEHLAACEFLELRNVDVDGMLSLLRGSTTLKEATVNPIDPLASFPHRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STD6</accession>
    <name>A0A9D4STD6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STD6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="19713" checksum="F69A1124A7D00E73" modified="2023-05-03" version="1">MDQDKLTPECRNVTSEDEASSSNIRPQRTATLSMKAKEIYEACRDERCRKLDAVWENVEIALQRLSCAKDGRKFTSAAKQLRASYERYEHVTARYTSFLDKQTRLKPGRNYSSKRQSMQTLRRSSAKSYVRLRNKNATTHRKQRRSSLYRPTQELPRDHNDRALPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUA9</accession>
    <name>A0A9D4SUA9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUA9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="824" mass="91232" checksum="7C8450FE8650B7FD" modified="2023-05-03" version="1">MAFEENLRHAAIADCPSQRMKSCAKSGIIVVYRCCRRHQRRHADSSTRITSWNDRDPPLLWRNAASVPAPFHRRLFQVSEPAGWQGLRSVPSSSALPGTCGDSEHCFTFNVPEDTVSIDEIIDSIEETVGDEGVLFLQHLGTTADQATSLLVNEGFCIRKEKVSVDAVGPPIVHVNVYRLPPYVSNDSLVAALQPCGKVRDLQYTTVQKRQTTYSGTRVVKMEMTRPAPNFVTVLGHRAMLEYRGMRRVCARCSGEGHMAATCTKPFSQRCSAFGHVTETCTVACRKCGGDHSAKECFRRKSYAAVTQSTVASQEDFASLSEALAVRTRTPDATPRLQVLKPTKRVVRRAPPDSMDSDSAYEQRSHDAKPETSSSESEVIAGESSSNAESVATTSNAVEASSDHPSSQLDSDSTSASTNDKPASSVTATEDGASAPCSGTEAARASHAATKATTGKRSGSRVTREEGQAQRSSARNRSRSRSAQRKLDCSLEEALLQLYFGHMDPTILHNEECIKYMETEVAASIGELDVLDPATWDRLKKRWRLISEEAGKERHARITSRMNETLRRIQIVERGGTSTQAMRDYVDAQRKVYSSPLHKRAQASRIADELQLPSDELRNLAFAVRVGTRRNQPQLILTAKREDGSITTEPVEVRNTFRTHFERLFAQEPQLDDCDIESRFLTFCDGLPKLKTEDTEGLHSPATKDEVSQALKAMNARSAPGPDGILTAFYVRFFEILGDLLTDVVNIFITEGKKPLSFRDGRVVLLLKEGMDRSNPKSWRPITLLNTDYKLVATLLVLRLRPLLNELVSPSSHVWSLAARLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUD5</accession>
    <name>A0A9D4SUD5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUD5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028897"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="13671" checksum="D2BC794CC43A3124" modified="2023-05-03" version="1">MNIKRVTVTIDKPVLHCSTYRRAAQEGTSESDKPLVAPGTKAEKKAGDDDAKAASESSAAAREVGPGATDVEMTAAGAIASKRAREASDSTGNVGTSGTGEPPKKTATGRRPTLKPRPNLPPDRGETPTPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUK8</accession>
    <name>A0A9D4SUK8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_015300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUK8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030711"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057217"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13152">
        <property type="entry name" value="KOW_GPKOW_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041993">
        <property type="entry name" value="GPKOW_KOW1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7947714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="545" mass="61090" checksum="6D6B468C8BBE6997" modified="2023-05-03" version="1">MPSLPKAEKKELVIPLIKNNVWRVPKNEKSVTQKDAEDIDVPDEDKTELSLEQQAIKEILAEAANSRNLDSKGTTKDMSIPLLMQNKVPDGYETDDKVDVSLRAEESTLEDYESVPIEEYGLAMLRGMGWNPGKPIGARCTEVAKPIEAVLRPKGLGLGADSKMAKPPPLVAKEDGDLVLRTGAYIRIEQGPHKDLYGQVEGLDDENARVIVKLALGGKTVTVSELFVSLVSKKDYQKYGKLLNKEKYDDYKRKHEAQEEEVAEKRRDERERHTSHKRSRVEKERESSKSAERRERSRSPKRKEQFWLRPQIRVRFIDRKYRNGKYYNTKLEVFVSVGEALKGYLGWNQHAASAQIVEGNVRGWQFVIVSLRGGFVRFEGADKDEGAVGAIAMFMTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVVLAVEKRVTSPLMEPTTIEKIVEIDNHIGCAVSGLMADSRTMVDRARVEAQNHWFLYNEKMQVESVALAVSNLAIQFGDSDDDGNAMSRPFGVAILFAGIDAKGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV17</accession>
    <name>A0A9D4SV17_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV17"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32701" checksum="16DB8471DB5972F1" modified="2023-05-03" version="1">MPAYSRPATGAPAVEQLSREFPKHPPTTAIIGSSQTTYLHRHFNPYDKATPAFRTIRGVSAFDIESELVNIPRSVTTLVFHVGTSELEMYGPDESLRRLRRLVNNTPRTLQKLQRLIILDARHSNETIKAYCRKLSKVSYVHREFDQLPPRCFLPRMAFLENSAHSVAETSKLPRGGRLNLALPPMYDHYKKISLEHYMHLTSRPTRRQRQQHNTTPKGEACRTTEPRPSTADTNTITANQHGHTAPNASQELGDRTFPATSKACRTHLQPADPSNAIPTPKRRLTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVP0</accession>
    <name>A0A9D4SVP0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVP0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32524" checksum="E7D98C4B08E83B11" modified="2023-05-03" version="1">MWSRFNVNFPRTANRKQHNACINRLSLKSGIERHHPQLCESIRHGSTILQVANGACRARPTEVHETSSFPEATRLAPCARATRRTFVIRDPHTPRAAGISQVKWTRLEETLGSDHHLVQTEIIYKRAPVKIGKAKITDWTAFRKEELTRSIEGLEEWTKLTTEKTQKYTKEMQLTLEKPAADPHLLHLWEARRSLIRRRKKQKRNRVLKKRIAELTRQADKYADELARHNWNQMCDRLQGTLGTRKTWNILKSMLSTTESKTNSRKNLAKLIHNYGGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVV7</accession>
    <name>A0A9D4SVV7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_007238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034237"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF55">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7951277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="383" mass="42729" checksum="F22F6248695500CC" modified="2023-05-03" version="1">METCVLIPPEFSLVLSTTEDSSKLDSDEDEATSKTHPYDMKVRLWANQAIPVGKIFSPAEGSVRLDRLEVYSLLDDNDVRHSLGCYDEIREVEERQVRHCNWVRFVRIAKRLSRTSPQQRQAPVLYRVLRPVQPNTELVAFFNDSAEEVHHIITTSTPKAAVGLERRLFQRTLQDFPLDLSQNLLSPSTSTSASSASSSSCRASSSTSSSSSGILRTPASISCTSTCSSSSPSTSEANNENIQEKPHKCPVCAKSFPTPGDLKTHAYVHSGSWPFRCHLCDRGFSKHTNLRNHLFLHTGDRPHTCDVCHKTFALACNLRAHMKTHQEGCPHVQCQRCRAEFPVSSRLVVNGLCQQCTHQPTLLPPPLTVAHQQDFSIRRLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWG8</accession>
    <name>A0A9D4SWG8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043803"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038757100" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="269" mass="30403" checksum="E90B27DB13CBFBB5" modified="2023-05-03" version="1">MITACHRNANLHLFISLDAIAVASSLHILHLSVPKWVQNGTEDSVVLDCVYNANREDEHLVIKWFLNDDPHPIYQWIPELNKRFVSSRLKDRINLDYSLTNGNSFTKFRALNLVRPTTELSGRYSCHVMSLAGQDSESKLMTVYAPPKRFDFTYERVSAHVTNLSCEADGVFPQPTLFLYQSSGRDPVSRPVASAPARMAAPTPAEGAAGYHVRLTYALDSRTLDVSGHVEYVFECVLAIPETNYRQQRRLEFEPVEQQMMNILVVMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWW8</accession>
    <name>A0A9D4SWW8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_013446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWW8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035431"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7956887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="454" mass="49771" checksum="A0D889580A640DA8" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLPAASSSSPQPYDDLCAAVLARYGETYHPLPGTREFRVSPPSKRAVPPGPQPSHDLDTSDTSGSTTATSPHALEPAIDTDIVTPAVRPPIAEASPAMSNEPAFSTSTLCASFQQELPSSSKSPAADVQAHNQLQPNVRDAATMTENPEDYPPGLPQVDQTAYAQPATQAYNPPAAPHTRSPSPTKQLHSVTTAVPSSSLSSTAHHTEISRATSICSARLVARLHSTRQLMQQPHPVMYHRQRRYRRRRRNNCVARPSRLRSRRRWRIENLTTGDDEVYEDGASKPRVSVPITLCFVIMIGYISGGAVIFSLWEGWEFLDGSYFCFVTLSTIGFGDLVPGDTVVSDSGSQEKLVICSLYLLVGMALIAMCFNLMQEEVIYKVRNCGKRIGIIKDTDDDEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWY0</accession>
    <name>A0A9D4SWY0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWY0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14207" checksum="293A04953ADD987B" modified="2023-05-03" version="1">MVPLPRPTKQGIDKHLCFDCQQRVFFAETSPLPYYNVTTGPYNESLNPACNPPPPLTPAYNTPPPTPQPNVPTEASPLYLSRYRQLGCQGCPPADHSFVRRTCGAPSTGGHFASIAEKLAMFTMISWKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX29</accession>
    <name>A0A9D4SX29_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX29"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="13033" checksum="CF65E967DA58BFEA" modified="2023-05-03" version="1">MDRRSAESPGTWNSAGSTQRTMTARWKQELFLLRRLNRRPQKRSAGKLHVQEGISLPDYVKTTISLGPKFAVEKKSSLAELLSFVRNVSRAVPDSESERYCFKYFRYCYFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX55</accession>
    <name>A0A9D4SX55_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX55"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="206" mass="22462" checksum="8AB51B3E348CB117" modified="2023-05-03" version="1">MAESSERLFRRERKRRVDASVQLASMNNDLAQPACRIRSPTESLPDTNSSGRALHQVEGTRQNEQTVAHPPELCGDSAVFVSDDVLHVVYQDVVGLVSSPISGGSRDNSIYLPPLQRRRPSSDVQSADYDHVSGAITSDDEESNVNFRQRLQAWAVESRCSHAAVTSLLSVLRSHTCFVSLPSTARTLLQTPGRTAANSAGLYTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXM3</accession>
    <name>A0A9D4SXM3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXM3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="28989" checksum="9680D975E24A748B" modified="2023-05-03" version="1">MIVADGLVQSFKCKGTVNETVKVLVDNTCVGEVFGVDPDIHLEDITSNISSSVGIISCTRRGNTLRVTFEGTTAPEELLLFKQRRAVRACLSRPLQCTRCGVYGHAAATCSRDRHCLRCGRGHTEGPCTAENPRCLNCKGRHPANEPRCSSWQLQRQTAFILATSGGKLTRRQALEKAQVAAQAKRNGAPAASTTRPGHSFRDALRDSGTPASNTTPPAKGSTSAAPTGDTKDSVMTALAAALRALLDSVVCDSPAREMCAAALAAHQAIAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXV3</accession>
    <name>A0A9D4SXV3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_005795</name>
        <name evidence="10" type="ORF">HPB52_008591</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047446"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7956059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7956355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="25381" checksum="CA9478B82A01ED81" modified="2023-05-03" version="1">MPAHCCVPQCTQRGFRDEDGSKDTDWRKRWIIAIKRDEGPFFTVTKFTKVCSRHFTEANYLPNVAGNRRFLKQDAVPSIFAFSAPRPPPRKKPGNREPLNLVSAPVPSEGGRSTTADVSDVDICFPTSVTSSIDGVVCGCACSLKISDLTEQLDVMTARVRALESEVKKKAEEVELTKSSLYKAERALDIAAQERSQLEKRVSRKFSVECFRDSPVYEDVSIEAVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY27</accession>
    <name>A0A9D4SY27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055969"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="134" mass="14969" checksum="B092BB1748E33DF8" modified="2023-05-03" version="1">MLVTITSGKSWIWRSSAPTSSRLHISVKEETLNETLDVENLADLVGTKIAYEAFSSLAPAYRDEILAGLDMSAEQLFFVNSCAKLCAQHAIPAKRYAPYRSRCIVPLMNMPEFSRAFDCAAGTPMNPREKCTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZV5</accession>
    <name>A0A9D4SZV5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZV5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043775"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="125"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="307" mass="35051" checksum="C0F548950B029815" modified="2023-05-03" version="1">MDNGMFRTCFRFEKEDVPKLRVALRIPETVMTAQRVPIPGDEALCITLRRLAYPNRLKDLENFFGRHSSRISSLTIEVLRHIDEKFFHLLDDVNNHSWLTIDMLENFSKAIYAKGAPLTNCWGFIDGTARAICRPTRQQQLYFSGHKRFHALKYQSIMCPNGIICQLDGCYPGSKHDAGNFGNSQAYTKLEKLVQGHHYCLYGDPAYPLRPLLLKPYGGASLTLEQCAFNKAMSNVRQAVEWGFGKISGLFAFVDFKKNQKIFRQNVARMYKASALLANCHTCLYGAQVSQYFDLQPPSLEVYLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3V8</accession>
    <name>A0A9D4T3V8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3V8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054656"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20818" checksum="B9731B5CF5326A23" modified="2023-05-03" version="1">MAHEALFEKVLNFATDVGLALNPSTVGTDFELAAINAIRTLLPSSDVHGCLFHMCQSVWRRVQHLALAVLYKNDVDGFTIKVRQLAALLFLPIEEVQDAYASLKPLFPQEASDLLRWWEDNYLLGRSCRRVAGANSTVIVYVVHRYSRHLFGMCLPSLRTDFQAATTLLRHGTDDDKYWLAHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6U2</accession>
    <name>A0A9D4T6U2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6U2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="63" mass="7215" checksum="68489FBD08E0D514" modified="2023-05-03" version="1">MDRSLDMLPQVTTVLHPLVKTHCCVTHVDIFVGRLNLYEHAALCDALRENEFVETLKLRGSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T711</accession>
    <name>A0A9D4T711_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T711"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052342"/>
    <dbReference type="OrthoDB" id="6503261at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="514" mass="54934" checksum="A34CE2BC5C0CB5F9" modified="2023-05-03" version="1">MAYNPSRREEICRLAGQISCQSLQLRDIVDNIYQRGQSPARPPSASSSPPGFVVRQSVSGGKGGGGRRASAAPQMGKDFSVNSKVATGGPGRKGSTSQFLTVQVPVSVASQFMATQKVDAGELSARQSVSSLGSDEGPKIPTTSHISRRPKPKAPPKPKAEEPEPAHPRPYEDDPIWGVWESNMLRLTQLLKMLLQELRSVSEYTKIDEPTLMAAAGVVGSGVPLAEASAADAFATKVAASSIIGGMYNRENVSNALHNPAPFQQLYAPPPQLKEQSSTDLLSSEPVREHIDLSIYFNKLASQMEALTQALKPNPFPPHAGAPMANRLIPLEENVGRLAHNLADVSRAIARPVDPLDVLMSSRAGSPAGQPIQVRAEAQVDNGEGVSMANRANVSFQIDRSSSQPSSSYPSSGAAGGGKGAGGLVQSDTMASLVASVNQLSNHMTQVQDLFRRALGARPVPKRREGLSVSEEEDLRYCVSKLTDNMSKMSRDLKETLKEHTTVPKDLDEDTEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7K9</accession>
    <name>A0A9D4T7K9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7K9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054224"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057503"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1083" mass="116104" checksum="7D1422BDB5F69F68" modified="2023-05-03" version="1">MAKAAEVIASPKTVILIVIAILIILIPPPGDKKTMKKMADADRPGSRSPKFAEGRQTPGMRPKSKSSSPKGAGTPKSASNETPRPPVVPQTAGSSKPAKSGPASLRPGGVPPLKASPTRGGATQKRDGTTPKKSGTPNVIFGSSSPARKAPPAEFGVPAQPGGKAQTQGAWKWLDVVRKHVGTPSLGGTPTPGGSPRVPGSPRLAATPARRDSLSAEQPPRRGAGVSPRAAKPNSPESEASKRKPESSKSPPASPKPGSPRAQFQGRQSPRSVSPTPASMSPTPGSLSPTPGSMSPTPGAQSPMSPPRERRPTISTKDPRLRHFWRSLRSHLRREKEAASPGEKSPNVDSPKQAPRLSMVDAAAAAAGFPTRKRLQPNAAGLASLALCPFTDTSRSRLAKSSPKKLPSSKQTVLAVAFITVIFAVVLIAIVWHLIGLVKVDPQHGSGAAANKGNASMGSLRSRAHAVATVAEAYSTFVRDAVDRSADPCDNFYRFACGSWAQSHPETSSAIEALVSFVNAALSKLREANALSMKGEPIGKAAGYLEICLAPDEGTAIVDLTAVLAGAGLTWPDRSEGSDFLSTVFFMAKRVALPVFFDVDVCLRGGKGGRRVLTFTTDATFKSVLKRLYNLISSLHVVSYLRVAYEAVAGRGVNETRFAEILEVIANATDVFDVYLQSSGKHEVVMNWTSVFQHTTPLIAEGKWNAVLQQYTRTSTSDVKSVAVPDFRSFAAVLGFPNNYGEAAAKDLLGFLAFQAAIFYTNAHLRDSFFASPEESVRQHRLQCFRDTYRFFRNAVNKFLLNGTEDSTKEVVTVARRVKSTFLGAFHAGSKSYGALPEQTRFVDDSLKTALALLAPSEVDADRFAYESYPNVSLQRPLLNHIAFAEHLARVGARVEPGTVVAAAVESHRPWHSLDDYFSVSYRRVVLNPYHLRFPWYVDRAPRSVLYAGIGSRLAATLLFDCVDKSSECRAVLDDNRGCLATNETGHHVTSIEDLQAALAGISVAWRAVRDDVDNATRYAVEASSQHTADGVFFIFACYYFCGEDGGEDMCNFPLKHVAGFAHAFECPSDSPMNPERKCSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9L6</accession>
    <name>A0A9D4T9L6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9L6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054688"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7983409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63762" checksum="B8138A9BF7AA818F" modified="2023-05-03" version="1">MQVNDSSRRIEGLLTSSRKYDDPKIQQDINHWPFKIVNQGGKPNICVEFKGEKKVFNAEEISAMVLTKMKETAEAYLGCPVKDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGEKNILIFDLGGGTFDVSILTIDEGSMFEVRSTAGDTHLGGEDFDNRLVNYFVEEFKRKHKRDLKTNARAIRRLRTACERAKRTLSSSSEASIEIDALFEGIDFYSKITRARFEEMCMDLFRSTLEPVEKALQDSKLSKSQIHEIVLVGGSTRIPRIQKLLKDFFNGKDLAMSINPDEAVAYGAAIQAAILTGDTSDIIKDVLLVDVAPLSLGIETAGGVMAKIVERNSRIPCKTSKTFTTYADNQTGVTIQVFEGERAMTKDNHLLGTFDLMGIPPAPRGVPQIQVTFDLDANGILQVSAKDESTGRSESIRITNDKGRLSKDEIDRMLADAEKYRQEDEKQRERVAARNNLESYVYNVKQSVEMVGPEKLDAADKQKVLSKCEEVINWIDRNTLAEKDEYDDKMKDMQQVCTPIMTKLHQGGGQAPPNQGGAAGPKIDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAF0</accession>
    <name>A0A9D4TAF0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">APCDD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAF0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033324"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042425">
        <property type="entry name" value="APCDD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029405">
        <property type="entry name" value="APCDD1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021">
        <property type="entry name" value="ADENOMATOSIS POLYPOSIS COLI DOWN-REGULATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_56, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14921">
        <property type="entry name" value="APCDDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01352">
        <property type="entry name" value="APCDDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="APCDD1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7983844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="169" mass="19422" checksum="1C1AEEC7D655087F" modified="2023-05-03" version="1">MLIYSRRKYQLNKCEVRSGPEFILRKYHFFDDSKFHMVQFFYLDSSCTVPAYALDGWGRLDLSSLSWVVPGATEAEASLSHLNVIAYTADVAERLSRAVNRSCPGEIKRPWETYLKYRLVSFVEGRIADKPLVEDFVCTGGLQFTLNELQLDRFWQVEPLGLAIDGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDC7</accession>
    <name>A0A9D4TDC7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_007099</name>
        <name evidence="11" type="ORF">HPB52_025207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000585">
        <property type="protein sequence ID" value="KAH7986101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDC7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037778"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042931"/>
    <dbReference type="OMA" id="EPWSRAR"/>
    <dbReference type="OrthoDB" id="5984119at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7946993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7986101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="142" mass="16284" checksum="FBDD84491831AE4B" modified="2023-05-03" version="1">MQMETDEYEFHYVKKESAEEEGRGGRRGRRSSGSSVGTSASGGGGRSSSGGSGSGSKRCDMRAKLERSRQSARECRARKKLRYQYLEELVADREKAVLVLRHELDMYRQYFKEMDQGNIPEAVLEILEKEQEEREQQIPQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDV3</accession>
    <name>A0A9D4TDV3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000316">
        <property type="protein sequence ID" value="KAH7986703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7986703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="293" mass="33353" checksum="646AF6FF22AE55CA" modified="2023-05-03" version="1">MDAVSDRSVNRERRCFTRQTRWFEETVHCLAREFFKRAFRVTPGIFRYMAQSDRCSSARIQTCAKPSRLIHVEEAYRGVFAVGRATVNEAYKELCEAVIETMENNLILLALVDYRYRLRYINVGSPGRCHDSYVYQLSLLEDAVQGPLFRRPLLTISGTAVPPLILCDQAFPLTANLTTPFCHRAQRYAENAFGITAAKWRISLRTISLHPDNVDYVIKAACVLHNFLSTHNPETHTFADTEDSSRNVVPGQWRESVEAASGDSSDPYFFPLKATRSRSYSKDAAAARDFFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDX0</accession>
    <name>A0A9D4TDX0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000285">
        <property type="protein sequence ID" value="KAH7986770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDX0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050770"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7986770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22247" checksum="FF931275F436885D" modified="2023-05-03" version="1">MPISGPILAAMAKQFPYILHETDFEPGGSWIQQFKGRHKIVYKAITGEAASLDMEAKRRGKEEAMPPEACEAPDNKGVPEWLPVLNEDASGLNDFLRADVEMSECLSDEAIVAHIHAAASGESDDSDDTVEQPTQVLSSQEAQQVTQSLRDFVFAKDLPLSYMEHLDALEKDVRHKLTDYGFSANKYILVALPYCMQIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YMI8</accession>
    <name>A0A9D4YMI8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YMI8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034281"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="3">
        <location>
            <begin position="305"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="415" mass="45172" checksum="CACFB9DA17316692" modified="2023-05-03" version="1">MKINQTVSDYLKQKAKILEAAEKASAGTQKNFRDGSHPQLEEALNMWLSATVARKIPVSGDLLRQKAETLALRMGFMTGIEDSATGQNPAVESPPTAAADILDDLRASGVDVGAALQRAERRHLGLDLKLFSLCTFCAISKWRRSSRTAAVAGFLKVVSRPLIGSHAARFSSAPFRFFHAIEMPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAECQTGDAGTDFLLVDMKVLNNFFAQAKCDKCDAKSLSVRKATDKEYGLAVKLIFSCSSCDFEKKQFSSPRVSGTATITPFEVNMRAMKGIQMIGKETPAIPFCCLRLAFDNQHESSKHHAREHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR51</accession>
    <name>A0A9D4YR51_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_024426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001171">
        <property type="protein sequence ID" value="KAH7984944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR51"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028643"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="304"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="417" mass="47996" checksum="CCF31714A95EF6E0" modified="2023-05-03" version="1">MHSSRWGPKNPHSKCYDAVGYHPCRVAAAGSRWHFDMHTKNCLKSQFCAEDNNNFHTKTECEYACPAYSFCLFDKAEVPCANSTGQSQWFFDPYTHRCKKSINCVTGGNAFISRSECISKCRAVDVCDAPRPAEICDSGQRTVWYYDKSRGACVKDVNCHNRGNNFPSLKECQRVCIRRVAPVPKPSKVCFTFPPTYGCGRLAERWVYNLDSKMCERMFVCPKSGNSFIRRSNCEYSCPSESFCSFPKPFLDPACANYPPAKHTWYYNPETRECRLGAACHLARSNAFPTRQRCSQICRSRDVCFEPPNPPLCPGKEKTVYIYNPIKRICEKSQGCDFRGNNFPTIEECSKTCERYRSPEDCHHWPNRGPCYDFQFKWYFDPHYKNCFQFLYGGCNGGPNLFDSREECLGVCVREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRI5</accession>
    <name>A0A9D4YRI5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000642">
        <property type="protein sequence ID" value="KAH7985937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRI5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12171" checksum="709282A4E8904075" modified="2023-05-03" version="1">MPSKIISLNNSLHCRVRPEDYERIRQERMTYMQISNDIAVVAIGDEDDDISSDKAIPFIRTYNTATQTQDKSSSASTSTSDKRAALKRPARAASDGDTPPLAKGRKVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRR5</accession>
    <name>A0A9D4YRR5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_024751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000299">
        <property type="protein sequence ID" value="KAH7986743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRR5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051027"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7986743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="18014" checksum="AC43D5FD334DE041" modified="2023-05-03" version="1">MQETAKDEDQGPKKEHSNIGGQLLYLTDDRQANIGEVRAGSEEKNRESWYLSWALDTNQEGRDKGKTMEVGCAYFKTENEHFTMLDAPGHRSFVPNMIADACQADMAVLPRRLGSNLVILVNKMDDPRVEWSKERYNECKDTLVPYLRKCGFNPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P8Y6</accession>
    <name>A0A9D4P8Y6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_025409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002048">
        <property type="protein sequence ID" value="KAH7931756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P8Y6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028952"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040501"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="566"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7931756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="72144" checksum="1C087C692CA50618" modified="2023-05-03" version="1">MMEGAAVVMEGDDLPPEDFGEEHGWRSAAVKKHSRRTDASATERATTCGDAGGYFNAIRKDLNLNKVIKSSRMPRLPSEHWKIIVRPRGGLDVQQTGSARLGRAIAVAAGIAPELAGQDVVCPNAMQNIIVISTASRANADSYLRMRCLTLGIKQYEINTYEAAPHATCKGVIRKIDISESQTDLEKSILTDRNPSALGVKRIKNSETVVIVFDGYKVPNFVYFGTALVRCSLYHRQHDCCYACGRLGHRADVCPTPDEAVCKQCGISNPGENHTCSPKCGLCGGPHATTDKSCKQRFQLPFIVRRRRRERRAESERRSQPSEPASADVGLTQHAEAQADDCDSSQRPRSPSRSSARSRSRSRGRKDGGFSEGRPRSRSKSRRRSKLRGRSRSRSRTGDPQGKVHFQGESEPALQGGTWADRVRSGGRPGGKVTGGTAPEQGLEELNQLRKENAEMRSIIESLRAEMAELRRTSKSQPTPSSASQLSGPPSPQPTEVPMVVEAGPSGNPAKRKAVSSSAENVQAKAKSEIKETLTSICLEIQRLNERLSVMDHRLTVMDRKIDAQNNVDCKVFTSFWHYVLMANYCWILMEGLYLHSLVFLAFFTDSSSILRYVALGWGLPVLFIVPWVVVRATLDDTLGAATDTSVDVPLVAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAK6</accession>
    <name>A0A9D4PAK6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_025643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010002282">
        <property type="protein sequence ID" value="KAH7931478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAK6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047218"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF10">
        <property type="entry name" value="ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="HD/PDEase" evidence="12">
        <location>
            <begin position="198"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="878"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7931478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112194" checksum="A923094971A22A31" modified="2023-05-03" version="1">METGTQRPDAGGESSVDPQTAHNRLHDKLDELEHILGPLGQRFSSAGFELALVGGSVRDALLGRPMPDLDFTTDARPDAILELIADWIEITTYRAEAYEEDSRKPMVAFGTDLDADLVRRDFTIGAMAIRLPSKTFVDPHHGFDDLIAGRIRTPGAAADSFSDDPLRMMRAARFTSQLGLDPVPEVSGLQLETDEHHRHKDVYQHSLTVLRQAVELEGRYAEKQREAGIADDDPQRLRVPDFTVRFAALMHDVGKPATRRFQPGGAVTFYHHDAVGAKLTAKRMKALRFDKDTTKAVGRLVELHLRFYGYGDAGWTDSAVRRYVTDAGRLLSRLHILTRADVTTRNKRKADRLAFAYDDLEERIEALAKQEELDSIRPDLDGKQIMAILDIEPSPLVGKAYKHLLELRMEHGPLGPERAESELRSWWESRAAREEFEWPRLTHFNFALDWFDKIAENNDKPALWIVEQDGSEGKWSFAELSARSNQVANHFRRAGIKRGDHVMVMLNNQVELWETMLAGIKLGAVLMPATTQLGPIDLTDRAERGHAEFVVAGAEDAAKFDDVDVEVVRIVVGGEPTRQQDYSYSDADDESTEFDPQGSSRADDLMLLYFTSGTTSKAKMVAHTHVSYPVGHLSTMYWMGLTPGDVHLNVASPGWAKHAWSNIFTPWIAEACVFLFNYSRFDANALMETMDRVGVTSFCAPPTVWRMLIQADLNHLKNPPTKALGAGEPLNPEIIDRVHSDWGVLIRDGFGQTESTLQIGNSPDQELKYGSMGKALPGFDVVLIDPATWNTKNLLNYPRAGVSGWTRFLPSIRVLVVGGLSLVIALCVAFAVGYAATDIPRAEPRGTGQTSTIYYSDGKTPIGQYKVEDRKSVEIDEISEADAEGRDRRRGHLRIRSAGRDDPTSQVPPTLRTTPRPYEDRFNYVVENMVDEGFLTEEQAAKVEMPEVRKQNKESSLSGQKGYMWDFVRREALRKLDIDEAQLDRGGYNIVTTFDKDRMKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAV8</accession>
    <name>A0A9D4PAV8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_025162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001896">
        <property type="protein sequence ID" value="KAH7931893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAV8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048874"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7931893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="70" mass="7637" checksum="1A2466696D0B0C16" modified="2023-05-03" version="1">MLLGCFIVSRVDRTDGSIDEPPATATKTKELLAEPPRMPAERRRSSFQAASLGQSCSIQLAQSIMSLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBL2</accession>
    <name>A0A9D4PBL2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBL2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027860"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="403" mass="45031" checksum="647A913B6549E056" modified="2023-05-03" version="1">MARKALTVSSIIEGALRPSVLLEHLLTSLQNVTHLEFSLVEAFNYAKEELLKIRLLANVHKGRETKVRKVYVEVADEKNADLLQTFLRYCPYLRDLHVHFVRYVRFDLGLVNRLSTFTFTCEASSTAQSDPRQPVDLSYCIDLHGNVVFRKRPQAYNCAQLRNLALSPNTAFPLEPVVLVAVETKDLGRQFLIAGSRHNWSKLRSLCVLLYAGNLDQTVCPTISANYETALRDFFAKLLNLVELNVSSFHFSDGVDFTELLAAPALRRLRALSLPPCGLRQNGAVRRLALGLSDIEDLDIRLNLDGRHESCSSCSRELVIAPADASAFRLGSGRLTLSNVPNLASLNFLECLQVSCLRFIDVSAGPRFDFHALAKVVRYGNILHSLVVKLQSIGFGESQQCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC18</accession>
    <name>A0A9D4PC18_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC18"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044542"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="247" mass="28054" checksum="E6F0BD17BD9E0E58" modified="2023-05-03" version="1">MAARETLRRRKRREEHELLVWCVARGESWTRLDAAASKTRPATKILTRDRERGVHWSIDSMNGPNGVNGLSGMPYTVGVNIFWDFTPIQEADLLRTIETYEYYLPQLRPALLARENHSPASIEKLFYREHFATARRTPAETNEFRKANNVTVRGRAVPTPILGLYEANFPECVTEAAYALNYGPLSALQSQCWPVALHGRDLVAIAHTRAPANEQAYLLPAISDPQGTAPLCSYSFRPERWQRKFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCG1</accession>
    <name>A0A9D4PCG1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCG1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="9449" checksum="B2FFBCDA0C48CD96" modified="2023-05-03" version="1">MEEMVVDPCSGRDRPTAATKLLSSSVASEAADSESDVRSDDSDAILPAKHRRSRRKSTTSSSSEETVKYCTIVTTTVAYVPVDVTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCW4</accession>
    <name>A0A9D4PCW4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_012350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCW4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033846"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="492"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="661"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="748"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="891"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7935692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="110726" checksum="7D896323CA5383CF" modified="2023-05-03" version="1">MVPPTSHSVDLTPLRPYTKYHFSVSAVTIKHGPETTATFDTDQALPEGVPTQLHYTNIARNTDTLTWAEVPCGQRNGPITSYYVEMDSIDPWETELRQTMVNWTSITYRDLLPYTRYQAKLYAQNGAGRSPLFASTNFTTPSALPDAPESITSSEQTEDSLKIQWDPPIRKNGVLRGYKLNSSISHTFDATLAKSWQPRSVLLNSSDSPEFYLRGLFPGSTYLVCVQAKTSAGFGEAICDNFSTKASIPEVQVEPRVGAIVNNTVSIMLYPVDFKKGPITGYYLVVLREGETIPRPVKLVNYSTARDMRLGYYVAAHLTPKQLEEAVDFLVGGGDVIGGFENPPLTDAMAYRFGLLAESNFSGEALYGYRLTAPVIVNGGSSAAGVGVVIGAILVLLILIIAAIALTFYYIRQRQAVAYRSKSPTKRSLKERLSRLSKLDENSMSESRMTLNMESSDSVNMTVVANGGLPSKPVPVKRLQEHVIQGQANGVLKEEYMTTPKGQLHPWDVAKKAENKPKNRYGNILPYDHSRVKLVPLPDFETTDYINASYVSGYRCPRKYIATQGPKQTSLTDFWRMVWQEGSCKIIMLTNLKEQEKTKCEQYWPETSQKYGKFVVTLMKTDTQVDFVVREFEISLENKARTVVQFHFTTWPDHGVPLYPDALLPFLRRIWDFQPHDDHPIIVHCSGGIGRTGTLILVDSMLSQAEAEGEVNLVAHLHAMRQSRVNLVESLEQYIFAYMALVEILCSKNHKLSVKEFVALYQKLKAKSAATGKSAIELEYEGFKRRKANLVTQLPLPETVDDFWEMLAGSGSVTLVTLGPLQDETTPQFWPSLKTTVKYGKVVVEQTDTQDFRGLLVRTFKVIYGSRPARILKQFHSQSWNRASTVPSSCDVVLEILQHVDRWQMQAEGRTVVVQCLDGCQESGLYCVSAAICDQLKLEQELDVFRSVRNVRCSRPEFIVDSEQYAFCYDLALSFLDTFDTYSNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDY8</accession>
    <name>A0A9D4PDY8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDY8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051659"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038527217" evidence="1">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10067" checksum="CEC95E510735EF6E" modified="2023-05-03" version="1">MARAVIIALLFALAVLAVASAQHRFNVEASGGGRNHRNFNVGGSVHGEYDLYRSRGGTPVVASGGVAHGATRIDGKTYKGRPQGSVGVGVEIPIGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE04</accession>
    <name>A0A9D4PE04_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE04"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036476"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7939330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40859" checksum="40AA61DC32639B9C" modified="2023-05-03" version="1">MRPLGEYLTMAEGGLVTRRRSGRAGRMIFNHGRNGKSLKLHKEKNVLAGFFVIARFHRALGYNFITRTTERGRPRSKILSSYLLYAIVSWILYVFVIGSDIVRVSTLLEDERNRVIDRAIQILGDVRCVGIQVSVVVLLLSKSQRFVDLLEYLVGLERRLTRATPLRRTAIVVVCLNVVFSFTSVLSISAEIYDFDEYSHAAYMKILYGMFSLVFAENVCMISFSWLAFFCSAFAGCLNLINDDVVRMSGELTVSPKELAELHRLFSDVGAAFARLEDLLGLAILICFPLNIVNAAPWGYYMLKADKGTTIFMLDLIGFLTICAEMFTAGIYARLTKHEVRMLLDIDVAPFLRCFKFISEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE45</accession>
    <name>A0A9D4PE45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE45"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="819" mass="92340" checksum="95CA2C1842913F31" modified="2023-05-03" version="1">MRRSLAHELTCPPVRGSPEQQQRARVVATAAAAMIAGNTIESGSAPGNATAARRPEVVVVQGLKRRGCEYIGQTPRNALKVFHGSTSGFRATFTFVCKMLILISLKLYFGFMLLRYIYWLPRMSVDGLPDALFEISEVILSLTADAGAESIWSNKSNLTLISTRYFEASEAEGGFEPGQGSLRSPSFWHDTLVRLLLFGHAMGGLSLYFASNMCSWMREDVVRDSSLEATLFFCLTLIAMTQIYIAMTTYTVFCLDGRRTIQCATEELQRTYQFISHDSLSRMHWKWEQCCRYLGDLSHNFLGFVCTWYTYLFARAVSLITLLCTTVFSANGAATTLTRQHLSVPMFELTYLVILGRLGQAQGDAAVTRRTTPGADLVQVKLRGRHPRRARRSWTQELTCPPARGSPEQQQRARVVATAMTAAITIESGSAPGNATAARRPEVVVVQGLKRRGCEYIGQTPRNALKVFHGSTSGFSATLTFVCKMLIMISLKLYFGFMLLRYIYWLPRKSMDNLPDALFEISEVILSLAADAGAESIWPYNSNLTLLATRYFEASEASEPGQASPRPTSFYHDTLVRLLLFGHAMGGLSLYFASNMCSWMREDVAQDSSLEATLFFCLTLLAMSQVYMAMTVYTVFCLDVRRTMQCATEELQRTYQFISHASLSRMHWKWEQCCRYLGDLSHNFLRFVCTWYCYLFVRTVYLITLLCTAVFSANGAATTLTRQQLSVPMFELTYLVILCAVSDKLKATLLSPFEQLQELTLSRPTSEVAIHIEVQRFMYRIRKYLTMTLFKLATWTKFALMTFGLVVLVLLVRVHVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFE8</accession>
    <name>A0A9D4PFE8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049144"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09942">
        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="547"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="731"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7936433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="819" mass="91760" checksum="85085BE5EB545381" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSLTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAECQTGDAGTDFLLGDMKVFNNFFAQAKCDKCDAKSLSVRKATDKEYGLAPQDEGYTDWLATHEGQRNIECNSGRMEVEAALTMFQRSWAKHGLRYTTVLSDGDSHTFHALSEAEVYGFIQIDKKDCINHVHKRMGAALRNLVDKKKAQGESLGGRGKLTQEKINKIANYYGYALRSNINDVPAMKRAVEATLLHMTSTDDAPKHSKCPEGASSWCKYNRALANGESPPSHKNALPACVGAALEPVFARLSDESLLARCCEGKTQNASENLHSVIWTQTSKNGNTSLESVKRAAAEAVAIYNQGRRATNESIAAKAGDEAAVVRFVGQLPAVHFRALRALMAHLCRICRLAHSRGWCERPLRLAHSLAFVVLRPPWEQVVAMARNARWHGRVLEILLLRGDWGESLPVFQNGGTPALPPRRPSRSSQQPPVDRSLLEAEWYWGDISREECSEKLKDAADGTFLVRDALDRGSGDYTLTLRVGGSNKLIKIYQRAGKYGFSEPLTFNSVPELISHYRRESLEHYNNFLNVRLLYPVSKYHQPDDEDQREWNVERVGQRLMETNREFLSRSRQFDQFHDQFNRLSQELQLKGQALQSFDEAAAMFEEQADLLRHFSRDCCSGEQDRRAVEENEALLQRRLALLREAQGRLADEVRASQAYYKQLEREINGLKLEVAQAAKQREKCQAWLQARGVPKDRINKLLQDSSGQQETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PII0</accession>
    <name>A0A9D4PII0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PII0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033631"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10589" checksum="70FCFCC263BC9CDB" modified="2023-05-03" version="1">MSPEYGTAYPAPCRVTRLSNGYEPSSSQTVEPRKHRTEVPGQKTYEVKRLLKEHYSPRSSVIAERCKSDRRVQQEGQSVEGFIVELKHLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKF8</accession>
    <name>A0A9D4PKF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKF8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035899"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040001"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42947" checksum="B6CD51E94403A4CC" modified="2023-05-03" version="1">MCSATHPDSWGSDHLPIVITPAGGKIPRTRQCSTLDWRAFRRTRTSCIWYQQHRKQPQSSFRCPKTMLCQTFATRTYGLPDAELREDGRVGRASGTLSEARGDAKVWRLLRSLVTGPMAPQAVLAVAIRLGKYWHNGRPIASWHCHQLDLGPSTPGLTPSRREATTLPGLTAKTTLCSLYADDVALWVKGPRRKLTAIRRSPQRSLDVVTSSFRAIGLIVSPTKTEALLVHPRVAAWRAVRRLVLGDRLIPWSKAVTYLGLRIDHRLTWIPAVKLATFKATRVQTAVGKLLSRGQGCTPRLALQLYEGAATALAPHPKEQLERQHHVAIRRFMGLPRLSPVAASLAESQTWPLSLLMRPQALHYVDHLHRAPGGGALLRRLRSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL32</accession>
    <name>A0A9D4PL32_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL32"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33194:SF4">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33194">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14799" checksum="C7DDBB315CC8A6B3" modified="2023-05-03" version="1">MRGKFPPEGVEANTMNRWPFAPPSVFREKGDEDLGDWLHLYERYGLALAWTDAQKADNLVFTLEDVARPWYLTALRENTLKTWEDWRTAVKENFSGDHVREWACIQLQQRQQQLGNMSRPSCSSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL42</accession>
    <name>A0A9D4PL42_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047924"/>
    <dbReference type="OMA" id="EYFWRPS"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="21905" checksum="493B76C8F55F7B29" modified="2023-05-03" version="1">MATQLKLVLFVGSCRTERLAERLKRYVTVQLEKRGHLVSVIDPEEEPNLLAVRKPLHFHGPDETPPAWLSRLHDKVKEAHGYLVLCPEYNRCIAPALGSAMDQFPPDSYRHKPCAIVAYSIGTGAGLAAAMQLRSFLGELGMVTVPFISLNAKIQELVAQDGSASDDGFSRRMAKLVAELEWYGAALRNHKEACGPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLP0</accession>
    <name>A0A9D4PLP0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLP0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15695" checksum="B7A42FEA73A24762" modified="2023-05-03" version="1">MQGWSACSEDSLRSSRDARRTRDHSPGHAQCWAEQLTVETPRRDPRCSRQGTEQQARPRSEMQYSRWQRRLRWWLAGTSTDGRVPWLEPGSPASDAWAHCLASPLLRLVPSHQALSHVSFTSGPIVEHHLYGPSQVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM30</accession>
    <name>A0A9D4PM30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM30"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16604" checksum="1F812B4C210BEAD1" modified="2023-05-03" version="1">MVDACQAATTATQKASVEVVKTLYKDFLSPVGNVDVIFDGTWKTRGHKSNIGVGCIELYTSLALDHVALSKYCRGCQGAPDPSDGGYADWAVNHECLKNIDCNASRMEVEAALILFRRSLEKKWAALYDHPFRQWQPHVPRSDRRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMD8</accession>
    <name>A0A9D4PMD8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_013575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMD8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035591"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049512"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="103"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7947571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="439" mass="49494" checksum="3C44BF901AB9B7A4" modified="2023-05-03" version="1">MELYKFRDERLKKFTDFLLSIRPIKMSALEGVFRKSLLHLRQKEIDQAYRVNILDVLIETLFSASSTMAFRSCRRLISFFKEEEYSKEEAENRRAPNFPVGEVTLKDCSFAWCKRDQKVDSPGLDGVNLLVESGSLVGVVGTVGSGKSSLLSAIVGDMRHLSGSVSLNGSIAVVSQAPQILNMTVRDNITFGRKFEDLHYSKVVEACQLSRDINRMAAGDLTEAGDKGEMLSGGQKQRVALARAVYSRSDIYLLDDPTSSQDARVAQNIMRRVLGHDGILGNKTRILVTNNSRLPLKPNQWVLMHKKRGITFRDLKDLKNHPCAPVELFEKPTSKHLPERTSSVNVGIALKTLLRSEIGTGDIFKLDNPCCRHRILRLCLEFELGGTLTLRRGHANRLGAFFYRKYINVITGIRVRFNVSHLLDSAHSRRELIAHRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMN7</accession>
    <name>A0A9D4PMN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040603"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35931" checksum="11EB44298E0F410F" modified="2023-05-03" version="1">MMSLSEASKFLLEALTPLDEDRQDLWLKRLLDSLQAQRINGPFLTKDDVLGCIREFERSDNDGTDVRLLVADAFSLAPLTYCQERRKFVPRELAGHSGPPRLFGDAGAKAFFFRERYQLVLQKTARHHCFSSRSRLPAASGFDLRPIEHLLGTTGERVVVLGMLCQLEEGNYFLEDTTGSVKIDTSGTKFTADLFVENSFVLAEGCYEDMAFHVDAMGLPPIEPASETLKYMGGASMFDMFPEKLRTQLELSDVPDNALFVLLSDVWLDQPKVLSHLRVLFTGFAQGAPACFVLAGNFLSRSTGLQKDRALLKVGLHKKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMY1</accession>
    <name>A0A9D4PMY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxysteroid 17-beta dehydrogenase 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051771"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8634" checksum="0DBD5780858015AC" modified="2023-05-03" version="1">MEVAPYFLLLLELLGVVGRCVLSVLVYMLRLVVPVSRKSLRDKHVLVTGAGHGLGREIALRCAQLGAKLILLDINKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNR9</accession>
    <name>A0A9D4PNR9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054480"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="6">
        <location>
            <begin position="269"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="517" mass="57974" checksum="3E0177AACAAFFB81" modified="2023-05-03" version="1">MSADNENVSASKKRRVGFEEEVGITEFVGKHKGFNGVLKQRYSDFLVNEIDPSGSIVRLETLEPPPEPKPDTSWADDNVTTEAKQHLELLADGQRAEPVVIPVTGLSKEQRGQVHAWIRAHWPHLESHTTTDGTVRVSRSTAQRRRATPWPSGRPSYTTFVLYKENMDTIEAVNRIATFLGMRPSFLGYAGTKDKRAKTCQRVSCHRLPAKKLLDLNRRQGLRVGNITFENAAIKLGDLQGNRFTIVLRDVDGTKADHEEAMQSLSANGFLNYYGTQRFGTTSVATHQIGRALLKGCYEEAVDLVLQPRDGECRAEWARSKDATQALAKLPHRGCIEGLLLRALTKGGATNYLGALLALPRNVRLLYLHGYQSYVWNRLVSRRVQRFGLTVLPGDLLMTPVADWYKEILAEDGLTLNSFSEQKHRELSMSGCYRHLVAVPREVQWQEVSYTDPQAALVLSDLDRLQGLPEPQSCESDDNARRALKLEFNLSSSCYATMAVRELLHRECTSWTPVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNX7</accession>
    <name>A0A9D4PNX7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNX7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039636392" evidence="2">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="495" mass="55384" checksum="85232289A898A99D" modified="2023-05-03" version="1">MREVVPVSMLLLLTLPCSAPFLRQRNPPFYNSDPLEDDVELPGGKVSFPNVLGGSKLLRLNNTRELIRSWTVVSRYIVHVLAKDPVRAGVCIIVLRCMGTCGASTCQDITINYRLLFHAYTASSWLVCAGVVFVAIFALSCDYNLDTGMKKLEKYVQDYKGKIHSFLEEKMVKASNSIVFLFASVDLRHAAQVTFENMSTQLKKSRYIFSQSFGGRAERAIAGKLRDDLKARSIFGEFVYNNSIVITVADLMQQLRGQLFAFGYEVRHVEDGVNSMTTILFTNATSDTSNRLDITGLKDLVKYSIIAMMFFVVVTMGGMMAGFTLGFANHYGHASPLERNALSNVAGYVLVLHCREHVGIGSLAGIKPKDLEAALDYKIDIRSLVEEVTARWKVVQEFKEQFEKRDLKTFLDFTIEECDNLKNNISSYIDENGYWLSIMGLVGIYVYGIYISLTASKYLYTMKSYTYEGEAVPPGVAAAAGTLNEDERLRSEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP87</accession>
    <name>A0A9D4PP87_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028010"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="4">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="302"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="5">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7948130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="66217" checksum="E7E5D7D81062DD60" modified="2023-05-03" version="1">MKALNFEALRSDLPPTILDDASRHKSPFYMFSKPEESRPSCVFGSSEFVPPHYKRREYLTGFSGETGTAVVLMDFAAVWVESRYMLQAEEELDCNWVLMNGGQPDVPVIEEWLKSNLRGSSRVGVDSRIYRKMEENLHPFGIELVGEPRHLVDEIWTPMEGRPYESNSSIVVHSVEFAGESWQDKVRKVREFLKKSGIDAILITDLGEIAWLYNMRGNDVPYTPVFEAFVFLSQDEQRLYWRDYKLVYNEMNINGNAVNRLLVSPFCSYAICGHIDIDKLVVSEAPIKMMMTVKNNIELRGLRNAHLKDSIVFVTMLAHMERDYLTKKPWTEARVIYELERLRSHQQHYRGESFSSVAAVGPNAAVPNHHYRNGSSVYISNTSLVLIDSGAQYLRYISIVIIADGALDVVARRSLWSVGLNFLHGVSHGLGSYMLAHEQPGYYEEERLGVRLETTMQITPFNTTYRFMSQKFCKFEPITFVPFQASLIKWELLNKAQLDWLNDYNARTLDVVGSELKRMKKHEVLSWLQARTFRVEMKNGSMPVLRVAGHHGLLTHEGSAGHHHAGHPGGQRPVEAFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPQ9</accession>
    <name>A0A9D4PPQ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPQ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="90" mass="10036" checksum="3FAE2CD1780013BD" modified="2023-05-03" version="1">MVGRSKANRGSWGNDNVSRRYEAAFLLVCTGVHCQQQSFRVRPQPVEVIEGRTVELRCEVANQAGAVQWSKDGFVLGESRRTLCQSHGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRW8</accession>
    <name>A0A9D4PRW8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRW8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029375"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="159" mass="18527" checksum="584D7E65F0027524" modified="2023-05-03" version="1">MTYGVLCFRLEAVRRQSVRVVVMNNLLPSVVPMHQKFDLKGSTFKRKASKHERSKRFPTFKDLDFLEQHPDGILLETDTTGGIPAKNSKGERLLLFIGVIDILQSYRLLKKLEHTWKSMFHDKDTISVQRPSFYAERFQEFLAKKVFKKITSPLEVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS45</accession>
    <name>A0A9D4PS45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051906"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11219" checksum="B798866EBB42D7D3" modified="2023-05-03" version="1">MDSPPQLSDELPSAFLEKELPKIYDEIKMHDHESSVELLNCWQASFFTSRNEDGESNEQYLDIGCGPGNFTRHYLLPLCPPVNEKTSSGGQLAPHDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSF2</accession>
    <name>A0A9D4PSF2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSF2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="32293" checksum="EED4F151CD233987" modified="2023-05-03" version="1">MAKRKFPVSLYRLRVVSVSDTIHSLWPAHEDIFANAFPLHVSKDLVVQSFKQQIYTSLHHLPKRRLSRNGLRYIEHRLPTAILSRRPRLVREAPSHCMPLVELSLVGTMSEDDRSLVDVLIGQLPHLRRVTQCRRNVTDHAQVPVAEELSKPTFSKERVTDSSLYQLVTCQRLLESEMCFDQRITVWSSFDLLRGLPCQQTAKIPFLTKAALCFPEGCKLSLVEYMARYLGLNDRTPGVTSTLKLFFLEQAKLGLELVGTMLKTLTLRMFACTLLPSASIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSH3</accession>
    <name>A0A9D4PSH3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSH3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9846" checksum="C1554CAD36EB10F9" modified="2023-05-03" version="1">MSSITVRAFDLLNSSSPISRGFKAPLRPSTFRYQKEAMEQAGRELMALQLATGKPVVQDSRRMSVISLAFTLKSVSHLAQAVFEADLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSJ9</accession>
    <name>A0A9D4PSJ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AAR2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">AAR2 splicing factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_022177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PRPF8 (via RNase H homology domain). Component of a U5 snRNP complex that contains PRPF8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051321"/>
    <dbReference type="OMA" id="CAFSDII"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000001">
        <property type="entry name" value="AAR2 splicing factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="9">
        <location>
            <begin position="215"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7952377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="391" mass="44345" checksum="303F860990113F36" modified="2023-05-03" version="1">MAEATEGASNVQVDPAVVDRLLLQGATLVFLDVPPGTEFGLDMSTNVVGDKFRGVKLIPAGLHFVHYSAVSKTGTAAPRTGFFHYFEKGEMLVKKWDKATEDISPEPVEKDEVERLRCNLRGDLDQYLAVFAYAEWRRWISLTKHVSRGVLERLQPERSVIYSATPFEPLDFCSRRGGDLASVDSRGDCGEDIRLSERARELLELKEVPECRIRYTEIPKKRHPSDSTPAEITKHGMDSSYVLEQLLATWPHKEDLLGELQFVFVCFLVGHVYPCFEQWQKLVRIFCTSSEAIDRHPDLFSNLVSVLHFQLREVPCDFFVDIVSRKNFLTEALASLFRNIAESNLPDDSPTTLKMKANRFKISLTKLMGWSFEQEVPEEECPVVVELPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTP8</accession>
    <name>A0A9D4PTP8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTP8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="82" mass="8934" checksum="472B0D9F25451B3F" modified="2023-05-03" version="1">MGYGLAPPTQKPCTKRQRAQSASTRPADASPKHAEQELAQGTQLAQSADAPPVHVEQYQSSGKHQQSAEAQPELVQQQVEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUF3</accession>
    <name>A0A9D4PUF3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043334"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7955796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="751" mass="83697" checksum="6AEB84EDD213290B" modified="2023-05-03" version="1">MALVAICLLLSALCVVGFAVLAVYFIFKGPVEPEDTTMLSTLMTPIVTWETTARSLMDNAKTPACVNFYEHVCGGWARDHRLRKGTNEFVSTDSLLQDELVHALLGTIQSSQEFDVKLASEVYDSCMQRGKVSDMSAEVVREFFRAREVKQWPLESYDVPRGEHGETMVWRFAAQLMVDLGLATLVTVDVGADPDRHPDLDASPDAPWPTILQLDRPKPLFASRAFTVPAVKKTLIDGFEEAVKALNAAATGQSLEAMSNGVADMFQLVSEQKLDDTRSYQPMNVSDLMSGLRTFVGQVFSYSEDTSKWRVLLPSRKYATIGLRKIVQTSDSVHLLNYMGFLAVIRMAAYMPDHALHDGGLQALFLHSVTGRSTAGTRETSLMCLYSTEQLLPGCFAKAALQYLHARGSDLAARHWIAQLVAAFARNVRDLSWMDDLSALLVRYRLKRRPIARLTAYDGGQCASSKTQPGDSGNPLKKFLDVAMLQQRALLQEISVASRVTYKYPVMPETHPYATFDVSHRYVRVPSVLFNQSVPTNSTAFALHLSRLATRFYHALVRVLFDDPYELVAPITEVANMRFTASDLSRCLSRDATQAYASDGNLFAASDAKRELLYRSTALVLAHRAFQQLLPVRRIWNMDFRYNGLPELSSEQLFFVYFALDHCEVSDDVHRMERAHVLTPEHMVNLPLRSTAAFAEAFKCSASSVSVASGGPPCRILSPSRTNRRSGRRTRNKTGQHRGLSSMVDLQLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVL2</accession>
    <name>A0A9D4PVL2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVL2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044166"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7956547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="456" mass="50984" checksum="E24831D4AFECE0D3" modified="2023-05-03" version="1">MDQGVNIKEEKRVEEVVHVEGDIAQQGRRIIKEHRFPPSWRVTWLGIFCQGFSITLDIVLHKKLEEDPLYGVEIAVAVGDVKEIGGIMGYVVGSVLMQATGRVTALYLYGIGMVFGTMVTVLSTMLPQLPTGFLICVFQAVSGVFMAVGSLTGYVYLTEVAPDEDRGVVAGIEHCCYLLGRLVGFVFPHAMPWQWLAVVSLIPSVFYIFCMRWVIESPLWLLQVDRLTEAQHAYDLLGIAVTGDECALSAIRVQRMRTPVKAMICAVFVFWLRMLGGPAGVQKFQNLQLVGSNDIFFGRKDLIMVVFEILIMPGIIFLMDTIGRRFLLYTSTVLLTVILLLSAYLVHRTIHAESLAENATFERAVMCASLCYVVANSVGLGPVSFLLCTEVLPPRRHGLLAGVLYSGVHVLFFLFRWSMRSDSYQVVHQFPLRDFADTYEPPEFVEDTETTTSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q258</accession>
    <name>A0A9D4Q258_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q258"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="183" mass="19663" checksum="4CD3F69CCA1848E9" modified="2023-05-03" version="1">MVRLVASSPAGHRFDVAAAPLIDAHFRLYRTKQLVPHEEVIALVVILASAVALTVLCILCCRRPRRKSPALHVPAATLPAAALRTTQDAEGIIHPDVAFRAATEATGAPAPLAEMLMKADDMLRVPADPPSGMITPLRPLSPAYQPTQPVSVRSTPCHHRALELTLPPGYIAQRDAKLTTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2E3</accession>
    <name>A0A9D4Q2E3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2E3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11742" checksum="71DE34950B0D98A8" modified="2023-05-03" version="1">MNSLTPTRRAAYVEQLKKLSPTFYRTARACTISPAPHQVCRNSWACRAKQKKPISIGSITPRISCYAGTVLTEGSQPHRPGKHPNTLFSGPAHRHSAALFQWVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3G4</accession>
    <name>A0A9D4Q3G4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3G4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039249399" description="ABC transporter domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="13051" checksum="49E42070A2C62B66" modified="2023-05-03" version="1">MILFAILCASPALITRAFRRISGAGEGDAAAEGVTAERLAVEKACVEGGDKTEYALVINGLSRFFGDAEVVKNASLAVRPGECLGLLGDNGSGKTTLLSMIAAIVPPSGGECYPKAGGVSGDEQKVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4D1</accession>
    <name>A0A9D4Q4D1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4D1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040630"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="310" mass="36141" checksum="CE773018EDF6701B" modified="2023-05-03" version="1">MAPSRSAEAEKLAKQILKIYFALVQYHFPLGLISRDVCTQWMELLRVILDRPVPDVANQVDEDERPELPWWKCKKWAFHIVTRIFERYGSPGSVSKEYGEFADFFLKAYTEGILQVVLRLLDQHRQKVYVSPRVLQHALNYLRHGVSHAFSWKFLKPHIVGIVLEVVFPLLCHNDQDDELWKTDPHEYIRLKYDVFEDFLSPVTAAQSWCHMDQMEAMLVAHVYPEFGSSEGFLRARACWVLHYFCEMPFRTEANLLRAVELLTHCLLHDSELPVRVEAAIALQACLTCQEKAQATVKPKIKEITMELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4T3</accession>
    <name>A0A9D4Q4T3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_004166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4T3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046165"/>
    <dbReference type="OMA" id="CLRPLIM"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7967927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="264" mass="30676" checksum="2BE8CFDA49C7999B" modified="2023-05-03" version="1">MSSPLTQLRKGQWLPPRDPRTLDWKLAGNVPFITTVILFYIYVVKFVGPRFMKGREPFKCLRPLIMVHNAAMIVVNVYFLFAIGSRTHFGGGASFFCQGLDLSGSANSIEVADILWWYLMVRIVDFLDTVFFVLRKKDSHVSVLHVGHHVMVVFTGWFGITYGPDGQAVLMVHVNTFVHVVMYTYYFLTLLGPRFQRYLWWKRYLTQLQIAQFIFMLVHAPIPLFVDCGYPLAHVLVIMSQVAFYFVMFVRFYMQAYRKRAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6Q0</accession>
    <name>A0A9D4Q6Q0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6Q0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029616"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="18366" checksum="8A4F754BED6E8F51" modified="2023-05-03" version="1">MRPVILQDVDCRSPHESGVPEPTPTRLFDARAVKDDGKEQLDSLHQLGRVFKEFGNDDFGLAVNLAFPWLAASPDRFVYDPEELTYGVLEIKCPYSLKDSQLEEAMSKKFCMIFEENYEAQLDREHEYYAQGLGQMVITGCLSADFVVCSENRIAIERICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9J0</accession>
    <name>A0A9D4Q9J0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9J0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26738" checksum="EFE8D9A7B5190365" modified="2023-05-03" version="1">MPVANRTKQRLEQILFRFLWSGSCVYVGRQVAKLPRYKGGLGIPDLGLMANALHVRWTHVALDSDMTLTRSFASFFLSTRLRQFSAGALSHCVPRAGTPSAFYAGAARTLAEIQRVDPEYDVVEVQLQELVDLITPPLPEHYKKFDLSRHKPSWKLITASFLDARRASFMYRLARGCLPITYRLFTKNIQRGVCPFCQSREDLAHIFCECAFPKALLRKVADLSSREFHFPRSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAV5</accession>
    <name>A0A9D4QAV5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_014421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAV5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046391"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7972641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="19073" checksum="5F87A57ABB840996" modified="2023-05-03" version="1">MSSPTTDHERRKQISVRGIAQVENVANVKKAFNRHVHYTLVKDRNVATPRDYFFALAYTVKDHLRVYYLSLEFYMGRSLTNTMVNLGIQNACDEALYQMGLDIEELEELEQDAGLGNGGLGRLAACFLDSMATLGMAAYGYGIRYEYGIFTQKIANGEQVGASVTPVSRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBS7</accession>
    <name>A0A9D4QBS7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBS7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="180" mass="19136" checksum="1AA4394D94FFD5C6" modified="2023-05-03" version="1">MPLEAMVEGEDISPETAAGCGWLTAYRRRNASKAHAAAKAPQHVGQHGAAAGAKPPSPLKRLATASKLPNLPKDHFSVVVRPGGGLDVRLCSQHKVFNALTMTARQSPSATEEDIVCSNSMQNIFVVSTPQETNALAFCTVQEIILTEQRHPVAAYLTPPGHSCRGVIRGADVDFTDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC64</accession>
    <name>A0A9D4QC64_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC64"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030108"/>
    <dbReference type="OMA" id="KEDLCCH"/>
    <dbReference type="OrthoDB" id="6483548at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="82353" checksum="94F1CB3E4F9F2FB2" modified="2023-05-03" version="1">MEPERRTLWSYATHLESLGLTHLKAADLALAFQAVATGALGRVVPYPTICTHNGGTRVCRIFEHLTLWNELLWFAMAELREVQPGRLAFVCQHFLRPMEYSCQDRLEYTYALIHCVLANHRCIVSVIVDYEMLQAYPALFNDALRRSTSIEQLQIDTSGLEFDEVGELIVDVCANCHLRELVCSEGRLLGSGNEVQARFAEFLKKSTTLRVLSVTNASCRSDYKVVLGPLQENSTITSLTIDSACIELDNGASLSKFLSSNSVLVELTVVKQTWRSSCNVGLLFKSLETNRVLQKLSLQRFLFTLADANSMSDALTVNTTLQELDIGNIEYTFIQPWLGMEGESDSAVKRAKSMWGELWRVQPFVNTLRNSVSLQRLLFGHVYFRDHELRSLLTAVKESDSFHQIQFLQVSCSGFCEFVRLVEETDTFDKVAIRHCYSNAMLFADSLRKCENLPLTGTHSFRFLDTANLREICSALRLHDSITSINLRTDRRLLEMFDERCAESLAMYVSSTTALKELDIAVNIVDKSVNRIVMAGLLANTTLERLGIFSCTLYDSDVRMFAKWIQQSKTLYGLSASFAPNDVCALFMSELASCLRSGYTLTSLNVADSESSQAHWQVIQGLLSRNSSLVVRAAHFAAGSTLKRCATAFELVSWHPLVYYRLAQTMSLDEVQQKLAASKKRLSVDFWQLAGVVKEDLCCHECDDGRLQIDDLGFDAWMALRKFLKVGDVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCD6</accession>
    <name>A0A9D4QCD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_005353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038544"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF74">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7975797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="23045" checksum="5F6FA1AD711E5B6F" modified="2023-05-03" version="1">MWWHSVNVFQPPVESTKRTLEAATAACANEVADVNQEVEIHADSVSQGAGDSSGAMFTVTSVSSENTDCKTDFILEDEGNEPLDFSGVIRLAMDWKNDQRQGNYVLVESKEVEYAMSDDDRNMSIYEEDGITLDQCLRLFTEPEVLDPQEAWYCPGCREHRQATKEFSLWRLPVVLVIQLKRFSFTRSIFRDKIDKMVDFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCH5</accession>
    <name>A0A9D4QCH5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM3</name>
        <name evidence="12" type="ORF">HPB52_001770</name>
        <name evidence="13" type="ORF">HPB52_018723</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCH5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056718"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057963"/>
    <dbReference type="OMA" id="NFEEMHK"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7975441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7976731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="11707" checksum="30FD92AEDD3817DB" modified="2023-05-03" version="1">MADDAEQTPATAVEEPLDLIRLSLDEKIYVKMRNERELRGRLHAYDQHLNMILGDVEETVTSVEIDEETYEEVYKSTRRSIPMLFVRGDGVILVSPPVRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEI5</accession>
    <name>A0A9D4QEI5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEI5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="15975" checksum="3D84655A88447B7D" modified="2023-05-03" version="1">MQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPPTRAVPPGPQPSHDRDLPSPATSLSTSRPATSAVVPAPDDPPDDVQVPTPEVPAPDDVPAAIDQSATTFHAGYLAARPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF80</accession>
    <name>A0A9D4QF80_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_001102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF80"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041179"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF35">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7981792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31096" checksum="85658E93C69497C7" modified="2023-05-03" version="1">MEAKSESEILYHLLENYRNATEAGKEALLRDMEFLVHQYDRAVDFVIMGGLLAIAPDLNSTSDAVRELVAHTLGSALQGNPKVQRTVLGQGLLPQLLRLIVLDSSARVRLRCLFALSCLVRQLPEAQEALLHHGGLTVLAGLFTAPDSSTKLQLKAVTLLHDLVVEQRLRHESGQPTDSQLTQSIQLHGFCSLVPRLLQSSDIDVQEKVVQAMAALAEVCLEEFQKHVPALQTLLGNYQRQAHREHSSEDADQAADYYEGLLHSVSQLLDTLQRKQKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFP6</accession>
    <name>A0A9D4QFP6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFP6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040482"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7977047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31818" checksum="E8319E8D421B91AD" modified="2023-05-03" version="1">MKTHLRSARNAKSSATGQFRTSGVREDWQNVLYGRQEEASAGSIPLLVRSLDPTRTVRDLDPQRVARELQTEAGVAPRSYCYMRLTRGGLLALGARTAEAAVRSQRVRCLGGTPVEVTVPLWHVHNAAKIRRVPTWIGDADIRERLYESAGVVSVRRLVAYGAPTAEGRRRDIPQTSVVLVFRPKMRRVPTSVTLCGVEYAVEPYALPPAQCMRCQRFGHEVAKCTERVARCKVCAGPHDYRRCDFRGHRLKCANCEGPHAATFAMCPLRRRFYATCANRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGZ6</accession>
    <name>A0A9D4QGZ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040767"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038932677" evidence="1">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15553" checksum="6C844FC00A4D30C6" modified="2023-05-03" version="1">MRAKQLLLLKDPSPGSIAKFFYLALALVVLLAAAQSGVMAQNEQLLMPWNQYRASPLLDALRGWIRRPSFTFTRPNFLPALSANAIRLRPGLQQVLRPMLQRPAIQSMIRPALNLRPVIATGIANLGSLIRRPFLNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIA7</accession>
    <name>A0A9D4QIA7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIA7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13447" checksum="D73C2BF26877BEA2" modified="2023-05-03" version="1">MDTERISVVAWVVDAARYWNRGAYAVSVVDAHGSLVNAATVVTNFTHEAEEMAIAVALLSCTGASIIHSDSRTAIRTLSAALVSSKAATVVNKLFYQERGEDNFPSSQVTWFPAHMGNISGSPSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJE4</accession>
    <name>A0A9D4QJE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="284" mass="31057" checksum="7FD5A3B4715E4978" modified="2023-05-03" version="1">MEYQVAGEDIAPEEITEETGWRTAGARRAGAPGRDDALLDGSVLEGAGPKGHGATRKTRVKLRVIKARRMPPLPREEIKIVIRPQGGLDILKIGAPTVTTAIFAAAGISTEESTEDTVCPNPRQNIVVVSTPRRTNADRYVRMRQLRIREMVYDVNAYETAPDNTAKGVIRGIPIEDGPQELDRKIVNSRNPTALAAKRIGTTTAVIVAFDGLKVPSLVRYGATLMRCSLYRKKIDVCYKCGHLGHRMDVCPNPNNRVCRVVDSATRIKDINATQSATCAAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM61</accession>
    <name>A0A9D4SM61_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_002559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM61"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044542"/>
    <dbReference type="OMA" id="QTHELTY"/>
    <dbReference type="OrthoDB" id="6518853at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="157"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="359"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7934983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="525" mass="59411" checksum="B19D333CFE26848C" modified="2023-05-03" version="1">MNGPNGVNGLTGMQDTTGVNIFWDYTPMETSDLLEKIRTYKYYLPFGDRLNASYTIWLHTFGIPPPVPKSQLRPALPAPENQSPSFAKFFYREHFATARRTQTEMNEFRKANNVTVRGRAVPTPILRLYEANFPECVAEAAYVLDYGPLTALQSQCWPVALHGRDLLAIIHSRTEASEQAYLLPAVVHVMNQPKPSTGKGPVVLVLIPTREGAEKVQRLVSDLQKYTHVHSVCLCSGDWKERQLKRLKKASYGIWIATPSRLLSFLEDGKVNISSCTLVVLDEADRMLAMGFEKTLRAVAALLRPDRQTLILANSGSRNVGDLADYLLKDYVQVSIGHSKLVENQRIEQTVIVYEKARKLDRLVVLLEDILREKEDKVIIFVETRLRADETVLELRLRDWSAVGIHGGKTRDERRWALDVFKSDSLNILVVTDVASQLLDVDRVRFVVHYDRPASSDIYVNRVNYASLCDGSGTAYAFLDPDDARHAKELVCHLQDVGQEVHPRLFEIAESASRCDRRKTARFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMJ4</accession>
    <name>A0A9D4SMJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040596"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042870"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="504" mass="54878" checksum="80FA307AB1F2AB01" modified="2023-05-03" version="1">MTGTGTGDGAALEDRPVQFMGLCMTARPDQDSAGLQAFKEFLSGEVNFLAALKNRAATYTALLEALAILSGKWLVPLWFRLDFIMTGNVSSIIIIEPEPLATFWQRLHAMLKTTYVTYVEQFIQVVYGTQSTLAPASYIKFLREESATVQGDVFDVLSVTASSRLPVPLDGRLSDLAEFAPKFTGDAWAAAVSKVVGWSVSEEYVVHASARQLLDAMNELAISTSAEYLLYHTVWWFVQQIGALTSNALFEATRVAVGESGNLYQGLLCGVQTSITYSTLLASRQATSVQPATRQSVEDTLNLVHSVAVTTVRSSNNLRLLVRDSAYYMLLETHPVVWPLPPNFDATKLGTYYGDTVDGSRGFFGHWHSSRLGIQRSFGRSIHTAASEFYKLDPTSLASYSPAFKGVSVATAAIQTPLYYGAGTAAMRFGGLGFTYAAQLVRNMDARALQDAAAIAESPVALEADHVFQSFECSDAKEKQAAFPHLPALVLAHAAYNRVRHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN81</accession>
    <name>A0A9D4SN81_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN81"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041765"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="17133" checksum="66C452C9C46EB24E" modified="2023-05-03" version="1">MLGWAERASEEYRNASFNLRKASTGILVDKETWEKCVTTVNTMMPEIVGYPYVREKFSEQAKKEINGVNTVGENIADNGGIRMAYKRIVKFHHDSRGVFKPDDASLLVIFNNDRISAAQLKHHACHGWMNRDPLQICSFCVYGHRAVKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP97</accession>
    <name>A0A9D4SP97_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP97"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051149"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42505" checksum="22FC7699137E0FDA" modified="2023-05-03" version="1">MPGECNFQSAWLSSDDYKRWIAPDASDPHRAKYTLCKKTFDIASMGESGRAESVASARTALETPVMRESARLFPNIEEQERAGKEIAASNNKHATEENHERASAGKAERTSRSQFRARTRTNAQQQQVCGKKKARAVSKFQSFSPLSERGSTQAASADLSGLSDHHGPEGIAETASRAEKRALAKQAACRANYKRFMKEVYPEIIKTKSPWPWSGISTTPDSPKSSQRSHAPGKRPLSETAETRLGRPSARPEKAPVGKRSYWYVPKALKDYKTDEKPREREGYKYRTPDPSSVDDSPIGTVKQPTYNFWQNSGRSWKRSTRPATELLMESDGVEAAVNSLKAAAAKGAETSSPKAPSPRVFKLLEWHGEEPPMPPKGESAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPA1</accession>
    <name>A0A9D4SPA1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPA1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="181" mass="20426" checksum="404F0D5BAE1331CC" modified="2023-05-03" version="1">MRSSSCVQLNLLRSTETEQQEGYSRKPKAVQLRLKAETNAAGFEGGSSWCFRFMRWNQLLTRAWTTGCQKLPDHFQAPLENASSFVREKIKNNVSASPTVWEKHRRENCHEFDGAAKWVNEAWNSISEKTIATGFHKVRLITADGDVGEFDTSETEEDGDVPAEVQPEVSNSEEDDLDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQR0</accession>
    <name>A0A9D4SQR0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_017887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQR0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051842"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7939820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="411" mass="46199" checksum="FD48AF4156565AA0" modified="2023-05-03" version="1">MNFSEIIAAILKFTSDLVESSTPAGVKRTMSSSRQRVRAVSPGHPSVAIQVLDVLNAAYIPTVIYLGLVGNVLSLITFLFTKLRSRTSSLYMGALAVSDSGFLIVLSFAWLNERGINVYRHGLCLVTVFFTSVFACWSVWLTVSFTAERFVAVRYPLWKLNDSSPSRRPRLVICATAFLSLTLNAPLLLFVRVGDGEFSDCSLHPTYESALFYLNILDTVITFIVPFLLITFMNFMIARAIYLFYLRYKKQPGVSDISMECQDFTSSARRLNSDTVVSNDATVTATSGGGIAHATQISITRMLLLVSTVFILLNLPSYVMRIYVFLLSLGHSELQDAEHNSLPYVLQRYFMLLYYTNFAMNFVLYSTSSRMFRVALCEYMQGRWLALRESMAGMRSSLGRSMTTQHEDVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR28</accession>
    <name>A0A9D4SR28_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_023055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR28"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027163"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7940341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47072" checksum="9D72A58DF52CB8F9" modified="2023-05-03" version="1">MSAHMNGSSPIVVGPKRVFTVDVAPAPGDFSKAGKHKRAPYSNMMRSFALQARLCRICGCCFIKDFLATPPRSPRIVWLHWYTLYAAACFAFYVWFEIDVVTRDAIELSDTHRFFTKSLLVLLHVVIIVKASGNFLTMVLGCRKMLDFFTAAARFERDVDVPSCKCCAQRHFFWYDLAGVLTLVVYFVSYTVALFHQEQKVDRDGEEWTLRDLVDRACSVFAAILFFVYDSVNFIALRRTAEVLVVYVTHLKEIMESYTGDKAVPCELEAAQKVQAMRLHLCTVQELKDSINGVLQISVVVSSVGLLLVTCISLFTVITEGLQRTELWIAIGYSAFNSYEFLRLAQVSQSLSNAVQYLHSSINPEDISLNGSDFFKINLALLVSMAGSIITYTVILVQTSPDLEATAACGPDATLTTTAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR51</accession>
    <name>A0A9D4SR51_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR51"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="9937" checksum="4BE789DD80CD2183" modified="2023-05-03" version="1">MSAVRTSFQDMFTAALTQALPEIVAQVSDSVLKAVQPWVSAQIKNTTQCCPPQLKRKTASRQAVDEDFSGLAPGGPVQHLMAAAPAPCPGRSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRM1</accession>
    <name>A0A9D4SRM1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_004878</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRM1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046267"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoreductase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="16">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7943061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="278" mass="30131" checksum="98E52F9C5EE07BA1" modified="2023-05-03" version="1">MEFECESGRVLRDALIENQSAEMYADVCKPKVLGTQCLDDVSRKECPELDHFVVFSSVSCGRGQIGQTNYGLANSVMERVCERRVADGLPGLAIQWGPIGEVGVVHESVGTDVDFFGLVPQPISSCMEVMDYCLSQREPVVSCFLKSSPSSKQGSKDTRDLVESVVHILGISDLSKMSPTVTLGELGIDSLMCVELKQLLERYYDVSVTTQEIRQLTVGQLKEISEGRSGSSPLSEVPAPDETGDDVKQAPEGKADDEFQETSSQPLVSSAVKPSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STC8</accession>
    <name>A0A9D4STC8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_021390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STC8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042719"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051465"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7944573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="25041" checksum="8D341BBE7F23749A" modified="2023-05-03" version="1">MHSFPNDPAQRQVWVDFVRRDRNRDWTPANGSRICSLHFGPDCYRAGNHRYLLEFGIEQSKKQYLEAEAVPTLMLASPASLLERLLLCYRIQQDFLTPAVSKVWVPQQQALLEQLKWAGVKLAGDSRADSPGYTSKYGTYSLLERTVNRLVDVMLVESNEVASSNHMELEGLKRAQQHLDDSGVPVHEVVTDRHAQINAADCGLHAASGHHTFCRIMYYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STJ0</accession>
    <name>A0A9D4STJ0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STJ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="10811" checksum="546D249019DF9993" modified="2023-05-03" version="1">MQQRERASGGQATAAAASLNRGAKRRAGPEPMDDETLHVSDISELLDKLRTDIISEISPIKLQLAEHTTRLQILESDRQRALLGTPPPPPAAPGKHALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STK3</accession>
    <name>A0A9D4STK3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STK3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16878" checksum="0A37FFD0A5588499" modified="2023-05-03" version="1">MSTKRETTIDLYMAIEMLQAAWMSVTASTIANCFRHASFGVNSGGDSEAIGAAANEGAAGDQDLASWDALLDAGVVPDCDTFCTYVSADADAVTTEELTEAEIVRAVTGVVNDDSDECVDDSPELVNPMFRRPRERWMRQTCCAASSALTMTARTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUK7</accession>
    <name>A0A9D4SUK7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_015150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUK7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045760"/>
    <dbReference type="OMA" id="NIVRAYN"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7947687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="287" mass="33474" checksum="FB87E6D3D6DE36D3" modified="2023-05-03" version="1">MKFSLNPVALSYRIRQMGDPRTRDYPLVTDPLFVFTLLLSYLYFVRVAGPRWMKNREPFRILHVVRVYNLVMVFLAVKFLVDVLPLTYLPGGEYSLWCQGITGRTSDAMRGYYRTGWVYAAARYFDLLDTVFFVLRKKFTQITHLHVVHHTIVVANTWLFTLFAPEGQPALGVCLNTFVHAVMYSYYFLATFGPAVRKYLWWKKYLTTFQIVQFLIIIAHMSVPLFVDCGFPKRLTLLCIAQTFIILCLFVNFYSRTYLNKPERSVLRQQNDSDGKTAEIIQSGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUN3</accession>
    <name>A0A9D4SUN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043918"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28834" checksum="170AD43D1607AB9B" modified="2023-05-03" version="1">MPRNMQSTYKEARRRARGEALLASVRLDKDRACFVDAASYTQEEAFCSVFVDCDSKVISCAVIRSSSSNVAEHVAIDLALTDGVRDTIYSDCKAAIQAFKMGVVAPQFPEHLGTIEGFSLNPNEEAHSAALVTRHILGDPSLSARTTRYASTTISQEECRLYHTPLYAGPKLSLSDDYKQALTRALRHYTQCTLNHSPSPDCALCGGYADFEHVPWGCASAGPPFTHEEMKKLIKGQDQTSQILVVQRASARAVRFNRTVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW39</accession>
    <name>A0A9D4SW39_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW39"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030864"/>
    <dbReference type="OMA" id="QLASHFC"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="146"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="37690" checksum="7A8227B2768FD936" modified="2023-05-03" version="1">MSGATPASVVSNSFEPCHQQHQASNDIIRRINCMLLQSGGSVQLGAVLEQLRKEPMLERVTSTEVLNACLNTRGQLNFHAKEGSVIICRGETPSLQSCTTDDESTTTRGKTTPLQSSAKDNPSTTGKPACCDVTVVQPLPDALGEEFFPVVVREVVSPEAVIINLVGRWSYELKALLEMMNLYYSNQGIGGIAGQMYRIQDLVAGALCAYPHVDLPSSKEENWCRGVVTSVLQNCMVRVTDVDSGVKTLKPTTSLRQLASHFRSLPRQAITVKLCRLRSAQGGVWGPEASARLAELVCGQTVMCRLVNYVKGVPGVVMCDTNGPEDVFVSNVLIEECLALPMSSDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWG1</accession>
    <name>A0A9D4SWG1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWG1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043955"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="19023" checksum="A0E3FFFCF97DF565" modified="2023-05-03" version="1">MNASGALRSLESFLPRRGYTYMLRGFNSPFLERRVVTFVSVMKSYYVCVICEAVAAKVWPLSCFHIVCDFCRNSLIGNLTDSVLRDGEALDETVLTGHSAVCPADSAPFKLDNLYIEPGDLSYLECELVLCLHADSGCRFVGQLRYLEYHYYNDCPFVPRIGYRSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWJ0</accession>
    <name>A0A9D4SWJ0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWJ0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13893" checksum="F3910D8A1BE988F3" modified="2023-05-03" version="1">MNYSDEQKTWLLKRSYNWQWTNENDYSLLFLMYGVRRGHDLVLAKKMLAYEDRHMEHSGRPRATTEEDDRLITAAIVADPFECAEDIREALSLTVSSETLRRPASQIASYKNDSCSLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWR1</accession>
    <name>A0A9D4SWR1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Brain-specific homeobox protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_020922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the distal-less homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWR1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053825"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000173">
        <property type="entry name" value="brain-specific homeobox protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="245" mass="25970" checksum="728F47A343F10F42" modified="2023-05-03" version="1">MMSAFYRKAVAVSEDDGGETATGYRQKMSPRRSFMIADILTAPPGTPLADSPLCLGPSPMHVRGSAVTSQGGAAGGPTCLQTPPLGPIYSQGSAVAAFLPAAHFIGKSIEQGSFLLSPGLAFPSLFGGPGSCEPGSRPCRRRKARTVFSDQQLHGLEKRFEAQRYLSTPERLELATALSLSETQVKTWFQNRRMKHKKQMRKVGEDTSSTAVATRHALTDDSNPGSCGSDLDGELDVVGDGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX56</accession>
    <name>A0A9D4SX56_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032449"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054407"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="353"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="552" mass="62267" checksum="ABE67A67136FF1DD" modified="2023-05-03" version="1">MRICLLRNPWDFPYASLRKFVSVLDFIALMITDGLLKPSRYRRLSWESIRLQRHLDSKPNELQYFSPSHFSLVPLGLPETDLSLMMSNVSIEQNAEEWDRWDSPSWFAIAFCLLGVVPGLFTSAVLTIYFFSTESAFETTLETEDLVEWMTSLDLDLGNVTALETVDPKDMMVRCSLDFGVHAIITIFLHDVFFANKKRAIVGERDEWASAFIKHTNNIYDGDDAILYKEALLDVLVELFESVDAGVMNRESVKTATSMVQKLREAFRTAFSTSSWVTGVVREVAIKKLENMQHYVGSPGQRLDPAKIDNYYDAVPDVDTKRFFKAYRGALQASTHRSWTDQKNWIFDETTVNAYYVRELNTVVIPAGILQHPFFNVDGPAALNYGGAGVTIGHEIMHGYDVGGSMYDEKSMQREWGTPEFMKKYTERTLCLRESHRAAEAKKARQGVLNDTVDSENLADFVGTALAHAAFASLPSAERNLALPGLNLTAEHLFFIGSCAKLCARQNVNSERYAASRFRCNVPLMNMAEFSSAFGCAPESPMNPSKKCAFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXA9</accession>
    <name>A0A9D4SXA9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_001694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXA9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040578"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="675"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7955598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="869" mass="96258" checksum="B93E6C99A0F7A456" modified="2023-05-03" version="1">MTSTTTQGLHLTRERKTDYEDTSTGVGVKKRVKSKRRRSFVEDEHANTTDVPAATNEVAAPTNLDSREPAADISAPPSSHEKDNAATDGSASRMPVLRSDHKGSSHPTPIKEKTEAAPQVSSGQGTTVSDAAKTHGSQLGSNLPDVGNATTSATPSRKSSGLTDKEPRNSEVVYTAAGARLTKFRAILTMSVTAVIVLAVVIVVFMPRRKQTAPMEPYCETDDCFQHSYRLLAKLNHSLDPCENFNAYVCSAWSPPERYLEHSNSAMDDVRKSWFPAFSDMLTLGSKTIRVGLKPLAMYSSCMANQSVYGSNVKIFWEMLKECRLNWPEEPEPHKNSALGVLITLAFKWQLPLFFQVRALRLKSTPNWRFNMDPGSLIPLMYQHHLAVKNSGGYEKYWATFYYILSAKYNESAVNKTTIATAKAIEGDVFKRLLTAMRPPVVHPVLVPISEVGPYTPSLSSAQWLRAFRETELDPEVELNDQILFGDTGFFLTLAGVMNSYKDTELLSLIAWSFVQLLSPAVDYRLLENRYEQGVTLYRPYFCERLVETAYRFLVIALHATSRFSPQERAFVTTGFDSLVSAAVDMVNASGWLDVESRKLAAAKLSWARLQLWPPERYLYNNILGNIYATFPSVEDSFAEYWAKSMRSAAETYRPRRDIDVQSYALNYALPYFLYDASSNTVKVAVGAVTAPLYYLSGTKSMFYGGLGYSMALVLVSSLDRQGLRWHPDGTFGASFLSKTSARAFEMRDSCLAAAQNGSGGSAETNKTVLERSNSVFPEIPALELAYMAYKRSVSDGSDNSPQGIPGGISGDKVFFMTLCYMMCTLPGAVGPHTVDCNKAVRNSEAFARAFRCPLGSQMNPRQKCAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYW3</accession>
    <name>A0A9D4SYW3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYW3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042960"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="814" mass="90733" checksum="1F8395D7C3050780" modified="2023-05-03" version="1">MMFVEDAVASLSVPWKWDILHRWKHGDWLRNRRHHPATAALLVDKSAAGEQQSFKLWFFFVFFLSPSLSLSFSFDDRMLLVYDRDLCTKEEDDPRDAIVFFHPVNMMLEQKCDLSCQLVGVVHFFNSCFDTPRAIELKKSKSPCECLTTTSSPAVCGLREFKIKHYQLAHVILGAPKSLANYVLQQQMDLVVRLLRFYHKGLADMNEACSSGEPFGERVREFFNACLPVCCGPKDQLSNLFQAVPTLNLPEAASNVYAKGYTHLEELQKMPGVLASCVTFDERVLASQFTPEMTQLLLLAATSKERLAMEDVPVKYFIPPAVRLVNVYLEASWLKDLAVINKQSNESPKELDKYVDHDDAAADDEKSLSRSTNLIQEQDACPNDDGTQRLPAAEDKEPERADSLSDVDSALSSQTTNHSSTCAPLASTILQVMGKRSLPDSDFLSDFDSAEDASDGAGPDACLRRLAELQYTVADCLRISQENLATDGRRRRRASTRNSRRNLRKYVSRPDLNRVLKDIDEVQGQEYASANTTPYRYDTDANVFQDYDAGMGFDAAGLFYQAQTMQTPTLISHFKSQRGKDTVATSTKEVATCQPHSQVLFVLYAKKFQRALTKFGEACSSLSLSKEVASGKKSLLGVLRKTCSRPSETKATTRPEQGVPSENTLNPFDLPPVVQVELGEALDVLVEESNKPLRKHKHDSGGSLGLNSMPEQEQPGSGNERVCSAEDVDRCTVLSDDDKRTDAGCSLPALAEQTQWHLQSIQHAHGEFLRSTCVNNMNALSLGNTWIQATRSEDHETFKVTIDDPKDLSPANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZK9</accession>
    <name>A0A9D4SZK9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZK9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054168"/>
    <dbReference type="OMA" id="FVEFNHK"/>
    <dbReference type="OrthoDB" id="77522at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="22615" checksum="01A76B60D83CA0D4" modified="2023-05-03" version="1">MTVSMFTKTVRLEQAVKLINQLDDTKFSALLARILQKLPCKDERSFTEEEEQKLQRAFNCDAQEVTLLLESLSFILEQAAFHLAKPQVLRTQLTDLGMEENKVQCMVQSWTSHAKQLVEQLKQRSLAPRQLRNVDWEVQVRTAQQSAARSKRLQALVDLVVSTGAAHDHLLLQFSHGQLFNLYTQLEQIQVQLDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T133</accession>
    <name>A0A9D4T133_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T133"/>
    <dbReference type="OrthoDB" id="7480986at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="71206" checksum="74EA4E4E1C65BBBD" modified="2023-05-03" version="1">MPPTNCETVVGKPALQCCHNTGGAMSTAEAPICASHRLRPQEQHSVKGSQPKDYEPPIPAPRKANIRKGCQRGVQEDPSAASCECTKASTSLSAGEGRDGCPRERTTDDGGGKARGPVSRDGADKASARRRGADKLREIRQAHRKRRNETRQSMGDGAPAATIAGTVLFRPKDRTVSFRVLPRPAIVRELYGIQGVAAVRVNFQRNVVAVDGVDRSAVLALVATGSIGGLEVLGRELAARPGTSSGIIYDHYNVKGRLTAEEMAEAEIVSSVPLVSYHPTQFGCSMLLRFDAPSPPAEVTVIEKHCLVQLDVKPNRPRPLQCSNCGRFNHATPSCLRPSRCMRCGKSGGHSHDSCTAEPKCGNCGRPHAMTDRHCRIWKQERRVEAALTAPNVISRRSARISVRAAYGDLGPRISKLRRRRPEGVKKKTAVVPSAPSSLQQKAPACSETKTSSVKSASKQPRDKLPRVAFVPSVFLAVPPPTVDKGKQKDLAGVSGAKLPPAKEATCQKKTAAERCMEAAKARSKKQLSSGSGKGTSTQRPTTVPSSQPSVKQSTAAAVSQWSSTPVTSKCCSTSIPLRLENQTSGARCQSKNVCRATSKTVGSAPGQAFSGSKTGESAKAQAAHCDQEEAFLGVLAQLARALQSGYNELSAPAENCKAKKKGGSKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T161</accession>
    <name>A0A9D4T161_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T161"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17583" checksum="444DD6D563F085AB" modified="2023-05-03" version="1">MRTLAKEGRHLPPTLEEPPPSPAAAADEPAPSVPPRSVKARSPFSRLTLHATDAGAALFRHKSPSKSPTRSLKSPPPKGKQQQQQQPQTAQQHADRSRQPTQSQKQQQQQSSSHHADQQQHSKGAHHSAASFARGLRFQLKRRNTSAFAGQLRPDPGPGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1X2</accession>
    <name>A0A9D4T1X2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_011715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1X2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035204"/>
    <dbReference type="OMA" id="CIENIAV"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000175">
        <property type="entry name" value="Beta-1,4-mannosyltransferase bre-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="459" mass="52205" checksum="939488D898B1ADC6" modified="2023-05-03" version="1">MQLSSRAKHLLHCCLCVGLILVFEVFTGGIHLWKFSYDDLDPVEQYGWPLTIVLYLMRLLTVLALPQCICNCLGLLLYNAFPEKVRLKGSPLLAPFICIRVVTRGDYPDLVRTNVARNIETCAEVGLENFIVEIVTDKPLGLAKHPRIREVVVPSSYRPKSGALFKARALQYCLEDDVSILGDDDWIVHLDEETLMTEDSVRGILNFALDGKHAFGQGLITYANERVVNWVTTLADSFRVADDMGKLRFQFWAFHRPLFSWKGSYVVTRAGAERKVSFDHGPDGSIAEDCFFSMVAYREGYTFDFIPGEMWEKSPFSFWDFLQQRKRWLQGIFLVVHSSAIPLRHKLFLALALYSWATIPLSTSNLVLAAFWPIPCPAVLNFLCAFVGAMNLYMYIFGVIKSFSLYRMGPVRFFLCLLGALSTIPFNVAIENVAVLWGCFGKKHRFYVVSKQLERPINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T229</accession>
    <name>A0A9D4T229_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_013683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T229"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037297"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000966">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7969016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="90" mass="10252" checksum="929F9498F00C8E70" modified="2023-05-03" version="1">MPALGQGNRLVCRYCGYVSSNASYLANHERTHTGERPFPCPVCPKAFNWKVDLKRHLRTHTGEKPFPCSLCGRSFRIRSHLTGHLRCHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T274</accession>
    <name>A0A9D4T274_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_011277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T274"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035290"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34520" checksum="95B41B8A7A0C5C6C" modified="2023-05-03" version="1">MPRSFPEEVHQLRCQESAEAGTVSNLKLHVGKLFRSSSATTANGAAPPSPSPPSSQTSIPPWNPARRIVTFVCLVSLICTAIIVAVVVAAVLLSRHIAHPSRQQQRYRRLMSDVAVDVVPKPQDLVDRTNTIVVHRKNPTAWQSQSRQLRSLLDSYATEGGAGSRCEPGGRCPFPVGLVSDNCSAADFFGYREGAPCVALVFRRAPDWTPQPLAPSDLASPAVPDEVREGYDPGLLYVTCKSEHISRDIDIRYSPYHGFPLRFFPATRHPPMLMLHFPNPPLRTEIWVTCRFWAKNLDQSSNGKVTFKLLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2J0</accession>
    <name>A0A9D4T2J0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2J0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="373"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7967769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="537" mass="59619" checksum="FAEC00477C43E12E" modified="2023-05-03" version="1">MDVQTEGEDSYPATCKPSEWTPIISAYKGGQLSPETQVVPSQSDPVSAKPTASAVEAPANAVPASLKPSYRARQQHLRAAHAVALRDNRRTSRPAQAIGSPNDHLPIAAYIAPPPSAVRGVISQAYWEETSEQMLQDLQTRNPDADIAARRMGRTLSILITFAHGPVPHTIRNMSVVHRCTQYKGSLDACTNCRRPGHRYDVCPHPKSGLCSRCGDKHERQDVPSSPHGHRIVQGEKSHRQTTQPTASEDKVLYEGGLSPLDKSNPSTSAWSSGATRPNGTTSQDSEVKALREEVKQLRAALSTSSPTLPQISPPPSLPTLSDQPPQKKRRPDESPAQPIDFEAKFQDLAKNLEARFTERITAQSIQLLPPILKSAVRLAASNPLLIIGDFNCAHVDWGYRRTNHSGTVLYNEALMLQLTIFNYFSLPTRIGNSVTADTSPDLTLGRNIADLQWERTQTTLGSDHHLIRIAVNYQRPRSKFNVRRVKWDQLRKLRQARPTQAPFDFASWVRQLQEDIRQLTQTLDTTPKIPVIDRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T442</accession>
    <name>A0A9D4T442_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T442"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="82" mass="9572" checksum="5297816111142A23" modified="2023-05-03" version="1">MSVACRAFVIVGKCSGRVRPEGFPHQQDHSVKHLHLGHRHLSWGAPDCRVFYHQQDHRVQPLHVAHHHLSWEALEYRWVDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T500</accession>
    <name>A0A9D4T500_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T500"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="194" mass="21779" checksum="68AA139CEB2C4D78" modified="2023-05-03" version="1">MRSSRASSEEREIRNRHSGIGWYAKELKAVLAPMPTNEPMIPAWFKNVDALFAALSIPEEQEVKGWLKPKDIAELAANFEESLDGSRQSNYRGHPKQSTELMSDLKEYDMGISCTTQEMAPEQNLPLRDQEQVSQGSNPSANAVQRTLEEPPSSEQQVPNTEGEANTSLEDKGEEEQDAQALEPQFFRRGAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5Q2</accession>
    <name>A0A9D4T5Q2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_014816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5Q2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027543"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038344"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7972663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="960" mass="107837" checksum="4BBB9C43DA75E809" modified="2023-05-03" version="1">MLTLPPSDLAHRADLVCVLLRDELAPAALAVAPAGTLRYWPNIAHEGSSTDALADLQGEECYSLTNTQPIGCILATTTSSLMLVTPSSVDGQTALLIKPLKAPQGLLAGISRRVSSFIFGAMPSQSSEARHLVKVLVEPTEEEDEKYVYVLLRNTLQKWNGVAVLMAALNPQVSQQLHYAIGTVDVRNVGSPNDSPVCFTDFTVLRFSEQYTERNEESLLNYKFVLPSVNRRTSFVYGTTKVYCVTPGSNVDDPDVIEFKKDKLLGAGSYEGTPLFFSHVHGIVCIRSVHAPAQDASRTVELLLQDHGSPEDNMELRSEAIIDETFLGRTEPSSEPDSALDTCVSRLGYRLVDDVPAMDPRWAHQHAPGGLGSSSLSLLIHHQLEDKLRAHQLLLNFLKGVGLWQRLYAVTVRGLPMATNLLLQEQAEKLVAAMQLRSLQSQFSGVIDAGIKRVIEARKVSGSGRLTAADHFYQQVSELDRIFPALVEEEEARLSKGISPKDELALITEVNSIIVKVLQEVCVFREKEQLLYEAAREISLEFRPWTSALREVLCKQHLVTVACAVPLVDEAFDRGRVYQQLCDLADLVLNGYKIQLDSLSHDPGAYEALELQYQKDRKNLIAPLIKATQYERAAALAEKYYDFTSLVEICETTKNKEKLQNYMIQFADQVCKAVLLMLMCIRMHSDFGFPEFVFKWQLDSGRRGELLRQPASQHRNLERFLEGHDSLSWLHAIQLGKMGQAANTLHSLGLREDKYLARKKTLLSLSKLAALASGDPPESRADLIKSINKEHELIMYQESLPAAVKEAYCLDPKNMQALGPEELIEMYISQDNMNADEYDFAKALELLSFIADQTRAQMLRMRIWCAAILRNQWEDLNTDDPSFKCRYVLNVHLRTHTGERPYKCELCSQRFSQLGTLSNHLRIHSGGRPHKCRLCPQSFAKKTELKEHMYIHRGELPYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5Z0</accession>
    <name>A0A9D4T5Z0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5Z0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026242"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="515" mass="57064" checksum="D02940671EFAA12A" modified="2023-05-03" version="1">MEVIVEGEDLPPELFSEDLGWQAAVARRSSNKATVARSFETKMEGFAPKAGGSAGERQNGDRVKRKVIKAARMPPLPKEDAKIILRPRGGLDVSRVGVTAVGRAIMKASGIDEAKANSDVICPNLQQNIVVVSTPDRENASRYTRIKTIEVASKIHEVSAYEAAPHSTCKGVIRGITLSDGPLDLERNIVNARNPLALGAKRIKNTGTVIVLFDGFKVPNFVRYGPVLVRCFLYRKQVDNCYACGKLGHRADVCPSPNDVVCRGCGSSNTDDHHQCTPKCKLCGGPHITADKICRQRYQIPYVVRRRRWEKAAEASGSKDGDDMAWSPLTQECKGRSSSKGRSHSRGRSRTKAGYRSWSRGRSRSRGISRNTARSRSRSRGRSGSRRREGEVRFETRRSRSRDRQHGGQPSWADRVRQGAAEKVTRGSPPECDRDNERLAQLERENKEMRDTIARLMAEISEIRSGGGQQPVEVVRESIQSTEVPVVEECERPAKKRAIVSEQDKASGRARLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T617</accession>
    <name>A0A9D4T617_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T617"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57508" checksum="21F66FB0617D249F" modified="2023-05-03" version="1">MLSDTEETLTATDKAATIGSSTDHNTASIPTAERTNDPQLGEGMDEDSAAFNTVTDATEDDAYNGACWKVVRNKRRARNAAAPEAASLLKTDSENPLTKPRPSGTTRLPPLPFGDEKVVLRPLGGLRLDKWPKPTLATALWAAAGVIPSDRKNFILRTRPEQNLAVISTPSSHVADALLQVQELSLGQRTYPVSSYLAAPDDSCKGIVPGLEPGTTSHTLVEEMQATGIQILQARMMGQTNIALVTFEGLRVPRFVRFLGAELRCYPHRPRQPVCKTCLILGHRADHCPTPDLIICEQCGIDNPMPSHPCSPRCKSCGGDHATTDPKCPRRQRQPFNRSWVKKAIDDERRQITASTDAAPSSATTHASETSKKTRIQEKRPTTPASQASPSPYKKALLSKPATSTATPDHQQPRASDNSNAMAAPREARHAQMHAQLDAAIESTNARIQAAIDNVRQESLALRKEIIAVIQASEERTHSLFAELVSRFDSVAPLPNPQAMRPQPPLTGARRTEPYSRPTTSSHDDDGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8G6</accession>
    <name>A0A9D4T8G6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8G6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15470" checksum="A6E324B2868A510B" modified="2023-05-03" version="1">MARPLNREQAFNNNFRRILPAIAHDRAQDQRAGSQSCENTCASRGTLKIAAEKPENQLPKVHKRIRYGAAVSRHFFRTRVAQSVAMSAASVLHTMMCASPRDQLLSTQRWACLYFAPSLLRALAETRYGRALRRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8I6</accession>
    <name>A0A9D4T8I6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046078"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20709" checksum="6D927F15461AD4D6" modified="2023-05-03" version="1">MKQTHPEVLALCGGFQPSLRSVQQPKKPAQENPIHTADGVILPEFVKRTLRQGPKYAIEPRLTAPKLLSLVRKVAGLAPDSEKERCISEGVDVLHRFKPKRRQLPIRKVVTYLIESGLCIIPSDKEGTIHALSAHPLSAWRDTCRPQTEEEKPERRQSSHTGYRFFLLRLRAAGVPPRAERVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8W9</accession>
    <name>A0A9D4T8W9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8W9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="75" mass="8443" checksum="A8C794CC83B74CC7" modified="2023-05-03" version="1">MGDEHSARLSVYAEKLDADAKQRYTEKIALSGGVERARKRHSTSLVPKVELSDIKEYLVHATSFVTLEQLKAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9V2</accession>
    <name>A0A9D4T9V2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_012397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9V2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="101" mass="11279" checksum="C1181067684868C3" modified="2023-05-03" version="1">MPEELRRSCGLNCGVKFATFSSASGSSQSLNHLVGFFYRTIRMIENGIKPVYVFDGKPPGMKSSELEKRQERREAAEKELEKAEEAVVHAVLTELYIGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA90</accession>
    <name>A0A9D4TA90_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_013986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA90"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053590"/>
    <dbReference type="OMA" id="FFCWKIP"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039502594" description="MD-2-related lipid-recognition domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16061" checksum="C3ED3387935FE45B" modified="2023-05-03" version="1">MESRCQLLLAALMLSTVACAVGDWPRCASPDGTIVSFHVDGCKEPDICVLKKGTEANVTIVFKSNVASNGVTVKVHGLIHKVPLPFPLPQSDACQCGVACPIKAGASYTYRGSFPVRPSYPSLSLDVKWELLDDNGNDLTCQLIPIQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAG5</accession>
    <name>A0A9D4TAG5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAG5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052608"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="183" mass="21352" checksum="D197FDE4B9A4693A" modified="2023-05-03" version="1">MSWLEIDSPKTDGSETSVESLQPLTPSTLKRHLRKAYGRRPMELVSRYFRAIFDLSAYANKAAFLARCRAMRVVPADYRVECPDIKNTRHVIRILDKCSYKLMLADLDYNRMRKVQVSRLLELLHQKLAKVLSHEDLHSVLALSKTKYENIFEVTREQQQGLFADLLKEYQISGEEEEEESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAL8</accession>
    <name>A0A9D4TAL8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAL8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15590" checksum="C8EBA1E773CFB078" modified="2023-05-03" version="1">MVCSCEPRILTETRGSYAVSLVAYWIGQLSICGNSPSHVFVRLFRRNPTVPREVHDVLARGPKCAFERNRSAPELLSLVRQVSRLVPKAEVERGASEGADVLSRHKPANMRLPLEKTVTFLKDSGLFLLPADKEGGFVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBR9</accession>
    <name>A0A9D4TBR9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_022246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047446"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7984548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="25449" checksum="0C6BFA2B3E1A446F" modified="2023-05-03" version="1">MPAHCCVPQCTQRGFRDEDGSKDTDWRKRWIIAIKRDEGPFFTVTKFTKVCSRHFTEANYLPNVAGNRRFLKQDAVPSIFAFSAPRPPPRKKPRNREPLNLVSATEPSEGGRSTTADVSDVDICSPTSVTSSIDGVVCGCACSLKISDLSEQLDVMTARVRALESEVKKKAEEVELTKSSLYKAERALDIAAQERSHLEKRVSRKFSVECFRDSPVYEDVSIEAVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBU0</accession>
    <name>A0A9D4TBU0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBU0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051215"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="36685" checksum="04BBCB347DB9AA68" modified="2023-05-03" version="1">MHMVTFGEDLQKSFGRQGKTLSLKFAFSLGMPVIDVLDYVHSYEYIHALADMEESSVLGCFRKDNGNNLYLQDFGFAYRYTQNGKRKEYMDDRTKVHYGTIEFVCRDVRIGAHSRKSDAKLLVYNVFQWISCRLPWKDNLMDPEHVSEQRNKLMENMPLLMSKCLPHGNIPCSITKLLQYAVPIKFEDSEHYKRRNRVSQKGIHTACFKPRSGLRFMPPRTQRRKWFSPKKPMLQEIILAEDSMGESGDENVMEKSQQSKVATTPATTPLWKRKHRSPAVTKSASWPHGVVKLEPKRKPVKKNAASSLSGWTCCKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCQ2</accession>
    <name>A0A9D4TCQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001022">
        <property type="protein sequence ID" value="KAH7985281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048343"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22133">
        <property type="entry name" value="F-box_FBXW7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000133">
        <property type="entry name" value="F-box and WD repeat domain-containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000032">
        <property type="entry name" value="F-box/WD repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="601"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7985281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="694" mass="76079" checksum="F5EC9B7895021768" modified="2023-05-03" version="1">MSAEERTGEGNDAKVDINTSSVDDLAGVVGLGRAAAEAIVAALAGGFNRVEDLLAVPGVDVSLLQELQLSLTCSPRENLPKDTQGTRWGSGSSSSCGSRDELATPSKVEATSLATSVNRLLHSEGLPTSDDDEGSCSSVEDMAEGDDDQAALSLAGSQLKRKREEVKRPGGKKPCGWEASYTAVNVAPPAPTRRTRHPSTLVQPPKLDAWLSTFQSWSHSERLVALDQLIEGCEPGQVRHMMNVIEPQFQRDFISLLPKELALYVLSFLEPRDLLRAAQTCHYWRILAEDNLLWREKCREAGLDDVQEVLGRRLSSCSVSPPSPSSVAPIPWKLAFMRHHYVEMNWRCKPIREPKVLRGHEDHVITCLQFSGNRIVSGSDDNTLKVWSATSGRCLRTLIGHTGGVWSSQMAGSLVVSGSTDRTLRVWNADTGMCLHTLYGHTSTVRCMHLYGNKVVSGSRDATLRVWDLETGECLHVLVGHVAAVRCVQYNGRLVVSGAYDYMVKVWDPRREECLHTLQGHTNRVYSLQFDGVHVVSGSLDTSIRVWDVETGACRHQLMGHQSLTSGMELRNNILVSGNADSTVKVWDIVTGQCLQTLAGAHKHQSAVTCLQFNSKFVVTSSDDGTVKLWDLRTGEFLRNLVALESGGSGASCGAFVLPPPSCALPSVLIEILQLSLQEFEMRFFYLPLYLIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD56</accession>
    <name>A0A9D4TD56_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_025303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000650">
        <property type="protein sequence ID" value="KAH7985919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048769"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7985919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="257" mass="29315" checksum="87C4FC9F11186EF2" modified="2023-05-03" version="1">MSRPAGTLSGDLLYTHANRASLFNERWSQPSSSHRRKFLSKFGSSLGRKHRRKHTHLSGDHSPGTTEPASPSLDYLDYQQDLPIQVRVEKPLCEVCHSHGHHPPHPKTLLEDMLKCRICGNSYHLRCLRAAGLPNQPRGALIDRHAWSCMKCETLELLLSDTELHSALDAVGMDADRRMTADLLTWPSFLELHERLYAGARDERGSLPPGVMALLREDFARFDRDHDGCISWAQVLTRFALQLLRQRHTDLFQDQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDY4</accession>
    <name>A0A9D4TDY4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000273">
        <property type="protein sequence ID" value="KAH7986793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039665"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="470" mass="51245" checksum="400B04FEADFD52E6" modified="2023-05-03" version="1">MDVRTLLLEMNTKLSSLLCLPEKVDGIEKSIEMLSAEFDSSLGLPKGGGGPLRALDTLQGPSIRTWPSRRTSEEPGGTRRSDYRTGPTRREEQTGGPGFDPLLAERIGPTPGREDHREGTWMPRPQRRTPAAPRDPDQPGPSRTALHHRRLPGGLGDDQHLQRRVPQRSPRPDAFGRGPPPPPWPRTGPRRRLLPRRPRRSRALHLGHSKGDRRLPRWTPRYRRHLDAPGFRGFGRVLSTSPFTLAARGRAPSSGPGRGCAVVYTTTSWSLRVRYLKRHLEGAHGVAVQQRFRLPHLLDAHLRWHDLHDVADPVARVPLPRLRSWSPAPYPIRGALSRHTGVAHALPAGPSSVTIAASPIGGLFARRGPPTLTSSTPGEAPAPRAGSPPTPPLASPGAASTASRSSLPSPTPPEPAAPDDPGPDAPVDDPAMDLPPDHTRLFAEQVRVLRATLRDGPTAESWEACEEGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE01</accession>
    <name>A0A9D4TE01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_024754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010000301">
        <property type="protein sequence ID" value="KAH7986737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049050"/>
    <dbReference type="OMA" id="IVIICEK"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="93"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7986737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="239" mass="27596" checksum="4632D8E9389AB425" modified="2023-05-03" version="1">MWIMTPSHLLSFLEEGKVNISSCTLLVLDEADRMMAMGFEKTLRSISAPVRPDRQTLIFVNSRSREIGDLSECLLNDYLQVSIGHCKLVENQRVEQIVIICEKAQKCERLVALLHDILREREDKVIVFVETRLMADEMVIELRHRDWSVVGIHGAKTRDERQKALDAFKSGSSSILVLTDVAAQQLDVDRVRFVVHYDRPANADVYVNRVRRALTDQEWRTPFWLLTTRVTRKSPSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE60</accession>
    <name>A0A9D4TE60_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000220">
        <property type="protein sequence ID" value="KAH7986917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE60"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="73" mass="8252" checksum="706C962BC36B4336" modified="2023-05-03" version="1">MELHSVAVVARNGRPAILDKPRELREEVSLTIERLQTRVKSVEVSVTTPRSEEQEAHSGNRAIRHQPRASNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE72</accession>
    <name>A0A9D4TE72_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000136">
        <property type="protein sequence ID" value="KAH7987083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE72"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="139"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7987083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="542" mass="60834" checksum="4958A76B82D5173F" modified="2023-05-03" version="1">MAGTVRPSDVRLLYRQVVLPAIAYASPIWWPERPDCRLRSRLLSVQRSVLLALTGAYKTTRTAALQLLLHAPPIELELWRLNREFTLFVLRQPVECDGHTYAADNVALPLDRWTRHPSCAPQERPVCRLSVQQARATARQYGLHVYTDGSHTSLSSGAAYVVFGRGTSTKAVGRYRVYGATSAYAAELVAFTEALVYLRSSASRMPAFVYTDCLSVLQAIASPYCLDPRVNHLRELMAQISASRPLRAFHVPGHRGLFGNELADYLAERACRVGLVRTVPQSVRDVRERFRHDMIETWARDWSVHHTSTELFKWTPDVRQLPAFYPPNRNLVTLLTGHGRFPCYFYRFGLMEEATCPCGGQCENLDHYYTVCPMTAPLVALMRHSADLATDDRRRVLADDRNRALLTQLVTTISEHTKHGLLLSCCTGPSAKNGGELFPSPCGASTCHRWFFFQRSGRASLFTGHRLRASPRTSQPARTPTVLAADPVIAGLQRQYIMDQGGPTFTWTPPQDIRTAAEQWTGGERTPTLMLETTPRRLQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPW4</accession>
    <name>A0A9D4YPW4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPW4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043307"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17204" checksum="84A529FD7E8AB8E1" modified="2023-05-03" version="1">MAWRFRFFRCHRTALPSGHLNTDGYTDSTGNTLLDTCTRDNRCRVANNEDCHDGYLKTCPTDQAYDVCMTMVVKNAQQGFFIEKKCALGPCNLRDEKQSQGLGLDTCDRSKDSYSCFECCKGDGCNTNAARRRSPLLSMPPLLLLTAVLAGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YS43</accession>
    <name>A0A9D4YS43_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000329">
        <property type="protein sequence ID" value="KAH7986673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YS43"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="390" mass="43898" checksum="C7D3275298B0C4A3" modified="2023-05-03" version="1">MRAGAEQEESEPFSEDSRAPMQVAEPIHPRGAIVEELMTLVTKPPPRAFQAYRLSEITKRFLDREHVGAALESYLVDIFTEAGRAPRKPRAPPPQSRCKRKRQEYAMCQDLFKQNRSHCVRSILDETGTSQVEDPAAFLEEWRDDIKSAMPLRNTASGPDGFSAKRLHSCPMILLRILCNILIMQKRLPLLLCNARTVFIVKMPGASTASLHRPITVSHVLTRLLHKIFVRRLMASIKLDYRQRAFIPVDGCAENLLLLQTVIDEAKHKLRPLAMASVDVGKAFDRVAHPAIINGLKRKGIAEDFCSYIADFYSRAPTVLTYGAHTKVAHPSRGVPQGDPLSPLLFNLVLDEFFEDQPANIAFQSDGLCVRDAFCGRHYPHSEYQSWAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P951</accession>
    <name>A0A9D4P951_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001759">
        <property type="protein sequence ID" value="KAH7932047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13623" checksum="C9829D37CFD5392B" modified="2023-05-03" version="1">MRQQFRSGELRFHGELCSQRENTPDGGRNDQRLLQVDGTSGSRRLDTNLCTRDTQEADLSSLAYHSEVVVKTRPYSARKASRQPVKKARPSRHDEHDASLFEDQYYDPSPAGNHQANPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PA52</accession>
    <name>A0A9D4PA52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunitTHOC2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_025481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002108">
        <property type="protein sequence ID" value="KAH7931652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PA52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049769"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050178"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7931652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="27070" checksum="0A57CE4089682958" modified="2023-05-03" version="1">MRDRIAGHVVHARNRRAGGSTSSAGEGRLGDVRGWVHEFQWKGRQADAHPRTCWQAAPRERESRLSKENVKPSGRQIGKLSHSNPCFLFDYGGYFHQLRNTKKSSQRLKDSLLEQDLALPLCLLMAQQKNCILYREQEASHLKLVGKLYDQADVAFFLARPMFGHQITLQRYVDAVDQVMSQVVENVRPLHPAKTWEDLSPQFYVTFWSLSMYDLYVPTSSYQREMQKLRGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAH4</accession>
    <name>A0A9D4PAH4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_004632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAH4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030128"/>
    <dbReference type="OMA" id="HFCLESE"/>
    <dbReference type="OrthoDB" id="8171816at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000016">
        <property type="entry name" value="polyadenylate-binding protein-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="6">
        <location>
            <begin position="44"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="349" mass="38506" checksum="AE46F209804A75AB" modified="2023-05-03" version="1">MASFVMKSTLSPEAPVFVPRHFKVPVPEPYPMSPPSQDSTRYAIVELMSFIEDVTLCPGEFDSKIGDLTRALGSVTDADGLIQVVDTIFQQGIKEPNFRYSGARLCNHLGSNLSVRGLDDGQFTNLLLDRCHAECLKRNDLASGDFGDAYLRGLLLFIAELFSQMVFLRDDYSYKVKHIAGCIPNMMHTLLQTPTKDNIKCTIQVLKLTGHSLEDFGNLEPGSTDGSILDSVFDKLREIVQKPDIDATASLMIKNVLDLREKNWGRSSSSSSSPSGCPSEENLPITCGPDGVPFSREEENFVQELLLEEQMGSLELSDGSGMYSNDCGNDEMDDEVAAAYEEFLKESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCN6</accession>
    <name>A0A9D4PCN6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCN6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040712"/>
    <dbReference type="OMA" id="GMPECCG"/>
    <dbReference type="OrthoDB" id="6763801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="374" mass="42469" checksum="7423AC1961184DD3" modified="2023-05-03" version="1">MLLVRSICTVLRQIKREKTIVNSSVIDPAKWMLCLRFAHVNRGTNSENTSSNSKRKAHFDSALSHESCDATLDSQVLQLLSALRLADALALTVKSFAADHRRYPSSKTATALISALARAGDVEGLRKMRDVVDILYPNVSADALRFEHYDAEALSRSGRAAEAILKFETLFLSHKGHRTKICSLLTFLAAYLVNNDMVEDVALLARMCERLADRGYFHPLTNVWKVFFLSERRRYHATASELVEAARLRPRAKPFFQKKVNSVISHAVDRCDVDMVQRLLNVVLYLGMPECCGLVLSFLLEFYCDADNLKSAQKTFEHSEAYGIELNPVTFYRYTCFLSSRGIQIPHDMLLKKYKMDPKNAKDTARQNNVKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDR8</accession>
    <name>A0A9D4PDR8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDR8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032760"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="24657" checksum="F97B8D9DD42170A2" modified="2023-05-03" version="1">MTLLFASAPFSTWQLADQLGPHICILKTHMDLLEDFNRESMLRLRDIAAKHDFLIMEDRKFADIGQTVQLQYTSGPFSTQLWTDMVTAHSLPGPGILTALQQASRPEQACVLIAEMSSAGTLTSKSYTEATVKMAEDFPDFVLGFVCQSRVSHNPGHIHMTPGVRLDASGDSLGQQYCDPGCAVTERGADIIIVGRGIVASANPEEAALRYKKAAYDAYLSTLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE96</accession>
    <name>A0A9D4PE96_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE96"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="195" mass="20177" checksum="BDA8F206D7F15B28" modified="2023-05-03" version="1">MTSPQPYDDLCAAVLARYGETYCPLPGTREFRVSPPSTRAVPPGPQPSHDHDLPSPATTRPTSRQATCASIPAPNHPPDEVQEVPAAIGHSTERSVFSTASAHGPSDLPAICTSSPTSTAHDTSDTSGSTTATSPLALEPAIDTDIGTSAVRPPNCGGIASDVKGTRLFDLYTVHILPAGTTILLEVSRSRSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEB3</accession>
    <name>A0A9D4PEB3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEB3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7938758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="665" mass="74227" checksum="2FBCDD9B24E31CE3" modified="2023-05-03" version="1">MNSHVLEEEEESMAESNILSPPGLALPPTPTPRKINVGTTATLVGISCTLLTVVVAFALVWISVQQGAIRRRNDTVSRETPFCCPAEAAKLFAVIDKQGVPCENFFEYVCRNALNQGYIQQNVAHEILGTSNYTVQAAATLQAFYRSCVTEIWQPDLRLKGAIEAVIEIANTTKRMSPALLLHFALEVQIRYKLNFPVTVDVDRGKMYFGRYLRLSDDYSPFCDHDCYATALAAVNAHIGANCTLEEVSQWEQLFTEDYSGPRSVSWDEIRAIFGGIEADEFRAILFEFRIDVNAIKSVFLVPGTQLIADIRRLWNITNQPVALCHLLVILVMDVMQLAVRSDATLSEPTIHSSEACEAPLYQNNHLWRITRVAALTSPEKDRQMRAIFEATRHSFVGYEPLRRIVAAGNDTAAFESLVSNMSLLLPVDLVLPEKTIPLLPSSGFIRNMMRLVSFEYEANVELKRRRLPVSQHTSWKDRILFMGSGSRLYVTPSSYAWLSTGTTNPLLADAPVLGSRIASWMWTNVYAWGWSEATVQAFRAFQKCVKQSQRLREYGNERQLFPLTMGLRIAATMGATSSGTGNNARAEWFRMKSAWSLYRMSEAQFFYARYAYFQCSEDKAPSVVNGPTLRSADFVAAFDCQRGSKDATETGCAGVAPTPGTFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEG2</accession>
    <name>A0A9D4PEG2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEG2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035783"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038767330" description="CCHC-type domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="77290" checksum="EDAA466C50C635E6" modified="2023-05-03" version="1">MLSEVLLLAALSSYALVEGSVQHPDLTSCSNGEEITISDVSIQNAKIGEDMLFNFTLRINQELSSDPTLQLTINTQNDTKVECFGVVGSCFRHATAELSLTAVRAALALPGNSPAMAAPNQVTGYDPESLRIVSMDTAQTEAPMPTEEEYLQDMLRVWRGKKNSAVASRDAGALAARQRTASRSQHAQGKSAPSVASQRIKQLQWRPKNTPRIEKDDIIVVLKPRETLDIKATFGPGQAGAAVRSILGADASVGLAVWPIWDQNVLVCTLKSVDAAEKLLRDITLPVGGRQLPFRGHPKLSGEFCRGVVHVSQDETSETVKSKLCAEPNVVTVRKLGDTTVAVITFAGTKVPRTVLYNCERLPVHLYKKTVPACPLCGTVGHRADTCPRPQPGRCISCGVQVPAATPDGPTEHQCVPSCLLCGGGHKTGAPGCAGRFRKPIKSGSPRGSKPKTAGGHKQPPMPKTSPKKAPAAKSNKPEPKKAHTGPSTNAKPGTPSKPPVLMVKDFPPLTPVQAQVSCWGGAVSGPSPSPSPTETALQQQIEELRRQNRFLARKIQELEAKQVGSSKPEQGAEVEDGDDGSSVTSDLTSVSRRDADTVVGSVSATGATGRLESLERKTEQLEERMAALPNQIMSAVRASFQDMFTAALTQVLPEIVAQVSDSVLKAVQPWVSTQIKNTTQCDSPQLKRKTASRQAVDEDFSGLATGGPARPPMAAAPAPGPGRSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEG5</accession>
    <name>A0A9D4PEG5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_002301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEG5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046561"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7938913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="326" mass="36507" checksum="CACD890ADC5E4117" modified="2023-05-03" version="1">MFVAKLAGCPFVDGICGKRDGKKSWLYWLICAPLRLIYSVVCIALCSCIGLVFVSIVVWLDGRTDQIKFVTRSGLYVVIYGQVVLNFCNLLVRRPQLADIVVTAAKLEPSLHLDMDNVRRRLRKVTLLCLLYTLIDAFKYVVGRRGQIKVAFYLLQGYDDHVKRLFVPWYIASCFLVSTWYNMAFWQIVYFSSLFREYFAALGDRLEIEMANECRPESKGLSSESVRLNLVELQKLLRKVNSFVGAQALCYYCGSVFFLCAMLYNTATASNTGVAEVASSWSYVVMMAVGIVFSTAAASRMTREASGGPGTLPVAHLVMLCAQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFF5</accession>
    <name>A0A9D4PFF5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFF5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054255"/>
    <dbReference type="OMA" id="RNHWNYQ"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="181" mass="20904" checksum="795338E552FBD30C" modified="2023-05-03" version="1">MAALVGLSGRFGQIARCQLKAPVITSCRSAGYWNKDWRPGPTPKTEEEMRAAAKKYKMLYEDYKVRAESEGLTWGDYPKIPTVTAGSRDPEEDYDFPTLKRNYGEPVNIYMDAYTPERLDLKRYKVPIRKQIAQFLGVVLGLWYLMDFFNRPELAFQYTINDIPVQMPNDGVVHYTFEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFM7</accession>
    <name>A0A9D4PFM7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFM7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034626"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="420" mass="47243" checksum="CB9058DC2F8E1F8D" modified="2023-05-03" version="1">MSDTAGYDESCTDQWKDQLDMDKLCGPVSSQETCWLCENFTAWNQVMSALGLGLEESMPGMLLLRCSFDVKAESERLATTRQASFLASWLLFHHPCIQELIFVAIDGSDEERTSLAQQLLADNSYDRVRLGPWTEPYLRVLSPVLASCRSSVEQIFLPDIGELSLDSVTVLCNALASCKRVKHLIVAVRQEPDARVALLCDTLKNNRYIERLNIEIENADSAKEILCALTVNAAVTFLDITLRVTANEESTKAFSDMLSRNDAITSMSVWLEGEDAQHFLDSIAKAMARNKFIVSFISRVDCRIYVPYSILESVRRNKCSLNRAVERRVDRRGAECFELFVGRPCMMSQVSEVAGITDEEARLKVVAAEHLLREKYFVLTGIVRSSVVCWPAVATQIDALNSDCWQAIARYLRLNDVCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHW0</accession>
    <name>A0A9D4PHW0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054016"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="692" mass="78385" checksum="2A44A329045992A5" modified="2023-05-03" version="1">MVSWEKSPFTNSLINYQTPCTSSEGRLCNVFGDISLWNEYFWEVGLQLREFLPGELSLVQMRHADVHPNRSQPEAAPTLLCRMLLHHRCIVSVHLNDHVFSGRHQLICDALRRSPSLRKLNLCRLNITGNASQSISAALRNLNQLKKLVFSHVTLDRTSLEGLSVFLAKTPSLKTLTMTDQCIEGENAVVVLQGLRQNKTISELSLDTSILSTVSSRCGDIFADYLRCNQTLRRLTITSCSHLLLRNLRPIFVALLCNNNLSNLCLIGFSLDTLSHEIITDMLLQNRGLTGLHITNCIFNEQDPHVNTRMPVLRSGSSPISLWLAALAQNSTLEELTLDLSWIKPKDCSSFFKALASNTSLKKVNVPTFRQDDVVEVCRALQDTDVPERFFVGEHHVCKDTAAALPECKAVSRIGLYRCSPDDVQQLHTTLRLLPTCSHVNSLCLEMSGPMFDGEVSSLIAQYLTETTTLKELRLELFSKTRQSVDQFEQALLEALSNNKSIRTLSLRRLCNSKGEVQSLVETLQSSRTLCRLFFYPSDYDATTSLIEMLSLIISSNYTLLGMRTHSLWFCRNWYPIKNVVRRNNSLVTRAAHFVMGTRHKYCADAAELMQFNPGLVEKVQELASVDENEALSRIEVCLNSFTEMKDFMCLAGVVKDTLSCHRRDDGQKQFVDLDRECWLCIRQYLNMRDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIH6</accession>
    <name>A0A9D4PIH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIH6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="14695" checksum="56B6C2EDA36D9E2B" modified="2023-05-03" version="1">MAAIPPEVSADDFVEVDCNVQAVASLADEDIVAAVAATQDAQADSSSVDEDRPVEVAAARAYSAAEVAAAFGLIRRCCGDMEGTGLSHLDSLAKIEASVFNCISKTKKQAKISDFFHANKTFCCIGCAELVVILECTDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ06</accession>
    <name>A0A9D4PJ06_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_009468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045067"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7943608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16063" checksum="D23952206F3553FA" modified="2023-05-03" version="1">MSRRAVGLADKMVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIIKFLTVMMKHGYIGEFEIVDDHRAGKIVVFLNGRLNKCGVISPRFDVQLKDTETWMRNLLPSRQFGYIVLTTSGGIMDHEEARRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ25</accession>
    <name>A0A9D4PJ25_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ25"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14327" checksum="63A2121C57FA71C3" modified="2023-05-03" version="1">MSAAFRAAATYIADATGMPQQPARGWRGACGVVANTKCTRAVRAGSNACIVGHLIQPILPLVAERQPSYTCHLVRRRQYCGLPPAAQEQLVLVHLKSVWREAKPTLQHSALLSRSFRPPATTPSGTLTFSCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJW3</accession>
    <name>A0A9D4PJW3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_018783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJW3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7944370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="328" mass="35475" checksum="23CD95F22B62D18F" modified="2023-05-03" version="1">MTPVREYKRAIPACYRCGTVGHRVELCPHPNDQRCGHCGQVVDASEEGTAPHECKPSCLVCGEGKLTGSQACKARLRLLQQPGRHHGGRSSTQQRSAPKTSDVTPEGRNPSPQDHCCQTYQSASATFTQDTTDVTEDVIQYTGPQCPELPAGKFPPLTDARALRRPTKNTSSQVGNGAKAAFSFCSSFPTSSPEFLELQRELSALKAQNAQLLAKIAVLRAVLAGLPAKPLVEERYPTQCSYAVLIRSLDAVATFFKAIRLIVSPTKTEALMAHPRAATRSAIRSLLLGDQPLPCSEAVMYIGLTIDPSLTWIPAASRHLQGYQCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK65</accession>
    <name>A0A9D4PK65_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041701"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="14025" checksum="15C7A9A982042F9F" modified="2023-05-03" version="1">MLLWFTIAGLAFAVTLLIRYYNGDVPFLLVKDLDFLEYAYIKNFKNFTARGETTKMIELRKAHPELRKPDILQSLLDAELEEETLSEAVTKGGTRQTANGLKKKVRALSPKEVIMNATLLFMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLT5</accession>
    <name>A0A9D4PLT5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shisa N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038138"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="237" mass="24922" checksum="2BCE481F8CFBD7D2" modified="2023-05-03" version="1">MEVPVLSEKGHKVLSAEYCYGYTDKFGKWNNGFQCPAQSSGEPVYCCGTSTEPYCCRKKEDEPPAPAHDQTLLLGVALGTLLVVALLALGACLLCRRRMAHKNRHQTINGGPIYRMHCGSSSANTYSFSGHDSGATTPGTAPSGGVAGGVGGPVAPGNCHQHAASDRGAISEPFSEMEPPPPPPRDISSFSGLLTPCPAGGLHYNGPMPHMEPPPPYQVESPHSTLLVRTIPSDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMP0</accession>
    <name>A0A9D4PMP0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_002253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMP0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050864"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="211"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7946646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="465" mass="51803" checksum="A0397BE06BF11E2D" modified="2023-05-03" version="1">MRCGIPETSRQQDTYCKDPGTSEKGIRYLFKGSTLYDDCSPDGCAPEIVASYLCDENFELVGERTITCTENGTWTHTRPKCRPHSYCDDFHVVNGEVFGERSGGEYFTPGDSAFITCAPGYRVNGTDQLYCEEEGFWDDDVPTCVESTCTRFEPAPHLIVYEFLNDNRTSFAEGTAINFNCEVGYQLRGAVFSTVCKNGGWIGRLPKCEEIRCGPLRAPVHGSMRGNYSTAVDATVEFGCFQGYTLLGPSRRTCGFNGQWDGEPVRCISNALLASQRRNGCEDPGTPDNGVRYGRPSYSVGSHIKFACNPGYYMRGNDTIRCEENRQWSARIPLCLGKFYYDTPRSVNNIITQEVGAISKPANTTVIDNGKAEGRTINLNKENVYPHYVYFLFDGSTSIGQKNFRTGISLAKAITRKPRQEPFDTLHMSSILGELIYHDVFRVSRDSSRVKGSKGGRTREDKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN80</accession>
    <name>A0A9D4PN80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN80"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031647"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="609" mass="60690" checksum="6FD50B93B2513054" modified="2023-05-03" version="1">MKQTSSSDSGTANAAEVCTNDDGAVKKPCRVWLVPAWIAFSFVAVLVIALGMLALCLFRVNALEGKVASLEERTYQLEVRSDGQAADQLSSAFLAARRRRRRRDVEPACLCPPGPPGRRGRRGAKGEIGELGPPGPPGLPGKPGFPGAIGIDGPKGDPGPMGLPGVAGPKGDKGDKGEGVVVRSTKGMKRSVTRLHGGTLGYTEVIAMKGAPGEPGPPGPPGLPGFDGRTGPPGDLGPPGPKGDKGDHGFVGLPGDPGETPVRTVVTGREVRKETLAPQAHPGPPGPPGQKGETGSKGPLGPKGEKGDEGKKGKRGRIGIFGKPGAKGERGDLGLKGERGVPGEKGEKGSSGDAGPSGEPGEMGPPGAMGLTGEMGLQGLPGLPGYPGPKGEKGIQGDYGPQGMMGPPGLSGPPGRQGPKGDKGDKGESSVAKYARHTLLGAMDDRDFSMIGGPPGPPGMPGEPGLQGPPGIKGARGADGQKGEPGEKGEAGSSGPLGLPGPAGSKGDPGKPGFDGRPGLTGERGEPGRKGDKGEPGIAGLDGLPGHQGEPGIPGLRGKPGRKGDKGDSAWSADPCLPGPNGLPNKGCSGDRKADGLPAAASSKHLSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNS5</accession>
    <name>A0A9D4PNS5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNS5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037164"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7946857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="609" mass="66835" checksum="F9643F0930ACEDE3" modified="2023-05-03" version="1">MQFAVRDDAVRESIEASGETPSASTRFSGSATASRRRLTRRRAREEAECAGWIEVASKKKKLAERADCNAGNAPTTATGSGNGGSRTAASQNVLRRVVKASRIPNLPRDHFKTIIRPRGGMDVKKTDLLIFKRSLAKAASLTAEQVFDDTLCTNPFQNIFVVATPFEANARAYARVQEISMGKTVIGLAAYVAASDDTCKGVVRGINVDLSDAELTEMIVNRRNPDALGVRRIKKTPTVIVLFDGQKVPQHVLCDGVRYPCSLYRRQVDVCYACGDLGHRSDVCPKGDDQKKCRGCGVQSPSPDHQCDPTCAICGGAHPTADRKCKKRFQVPYIVRQRRRRRRRRARRGSDAAGGEEAMAEEEPFSSPHRGISASRGRSRSRGRSGSKSRSRSRGRDKGSSRSRSRGRSGSKGRVQKQMSWADKARMNIPSGQEVTQGILPEQKREQSEILMLKKENAELKEALRTLRSEFELFRNSREPRAVVTPIPVQAGGSNKRKAVSPPATVESEATQSDEFSAQVPEQNVIASLAAIEESLKQMREALAIDSSTIERMDGSVSHLARRVGILESKMKIIDSSKFQTTNTGTIPKAKIVQQDSDAPNSPQAMLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPK7</accession>
    <name>A0A9D4PPK7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_011968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPK7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049938"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7947442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="243" mass="26807" checksum="9F75E3E02BC78CA5" modified="2023-05-03" version="1">MRLSAYAGDLRGPAKLRYEDKVHLCGGIDPFDFSSDEAAAIQVFSIVDASEPLRSSSLRDVFPVLALVYNNFSAAKGGLEVTLTVRTLPLHGEAFVRMLVTQHRMHELIMHWLSNRLYAGWLLAHASVAAHLLRSGTVSFLAEDRRNNVAVTRAPVPPGRRVRQHHHVDYIGNERKCTGVHVCRAYSLWEMAISVVPDRSVGLQFCQASRTCHTQEHLAVTHQPSAQAPCATLGSSCGHPLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPY4</accession>
    <name>A0A9D4PPY4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027833"/>
    <dbReference type="OMA" id="HHYVYRQ"/>
    <dbReference type="OrthoDB" id="8021718at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038844532" description="Cuticular protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7948535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="37938" checksum="A0364CE9B306DCCF" modified="2023-05-03" version="1">MKEQLTLLFLLIGSTCAALGRVRAPLAEIGTSTQFRNEDGLGNYNFGYDEDHTSGGSFRRETGTALGAKEGSYGLRDADGRVRVVSYVADELGFRASISTNEPGTMPSTPAGVNIGVPQQGPVAPAVPVAAPAPAAPALAAPTLAAPAPAAYASPTRVAFNAAPARRPTYTPQEPVVTFFQGAPTPLDIKSAPVGPQSYGVPSPLDIKSAPVGPASYGGLAAALFGASPLAPAAHPAPAPWSGVYSGPVQSPAAPGAYRPPPPATYNASPLAPAAYGPSLPATSPFGAPAAPFLGAPLAMPVGHHYVYRQDNFVTLPADGRPYPTHPAPHAYPSPYSSPHAGPVAHVTTSHAYSHKIAHSLGGGHHRSYTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQH2</accession>
    <name>A0A9D4PQH2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aconitase A/isopropylmalate dehydratase small subunit swivel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQH2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027316"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7950988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12375" checksum="4FD87A24DCBD380D" modified="2023-05-03" version="1">MDIFDAAERYKKEGAPPLMVLAGKEYGSGSSRDWAAKGPFLLGIRMVLAESYERIHRSNLVGMGIVPLQYLPGQSAQSLGLTGRERFTLRLGKDLVPGQKVTLQTPILFFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQM3</accession>
    <name>A0A9D4PQM3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQM3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="536" mass="60003" checksum="89B0119C1062E4E0" modified="2023-05-03" version="1">MECTVTGTELHPTAFNPDEWKEVLDARKKHHKQKSKTDALSRAENASVAVEPQLVRQDSVQTPAEKLGTTASAARLRRGPIPQLPTDDFKVVYRPNAGVNMAAFTERELRAALLESSGLVESCTQGDLTRTNLVKNVFTMSTACHERVAKYAQIRQITPRGKKIEVNAYIAPPDRAIQGIIYRAYNGESPQEILRELRRSNPLLRIVQARDMGRTSKSVLIHFMSDTLPESVKFFGSVFGVYSFRPEVEACTNCRRTGQRRDVCPEPMRSHCLDCGQQHPADQQCSPICIACGGDHRTGDRLCRRKYQRGTTERTRTSTPHQQQTTPDFQVDQASFPPLTSATGEGRTGSKSPRRNTPPMLPTVNQDSQKVSCVDSVSHHSNSRSDSRDLYYQSTIDRLTKENQDLKRQLSLILERLNALTHVKSAQPTTCQEPVEIRDSLHTDSGDHSEIHHSLAEDCPPRKKRTLESTSDVSDTSAQALEEHINKVEQRMDHGFAQIAERFARLEQVITDLTTKLLAPAPPPVPPPSHHDFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQY1</accession>
    <name>A0A9D4PQY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044915"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16264" checksum="071F0796837C91EF" modified="2023-05-03" version="1">MNFRTGFGFNPNIFSALAEKTKHMDSFSCRGGIVFDEMKLSDHLDVKSNGELEGFVDLAQFTSESQKEQLSDHGMVVLFQPFQGKWTQVLGVFASRSNVKADTLAKIIVEATILCEKAGLLVDYVTCDGASWNRSMWKLFGIRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRE7</accession>
    <name>A0A9D4PRE7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051290"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="721" mass="80138" checksum="3BA9667BCC62D2CE" modified="2023-05-03" version="1">MITNYAERDTSREPSSFKQALTGSSYRRLVGESTSSKIVVNEGATSADAMNKTTGEISDRKMRKPVVRFGATTVYEITSFTLSQLTSHTDHFYALLGLAITFAAFWFSVVSSALCASSAECSSARESLDALMDPYVEPCADFHRHVCNKWMLDYNTDIVNTAQRDAIRVATDTLLSTGGPSTVAIPRAFRRFYTACYSFLATTSLPSLFAILEPLRIYADILYTDNFSVLLERAILLSLDQGIHVFLKLSLVNDTGRTSLQLSMANTLTENLYSEATEIDESFMLRALLDYALAGTSMRTSPATILKLDQMLSSRVESEPTLRLPITRIGEMIAFMDTKLWLRCLNSVLSPDAHFENDSLLVTADSRKIEHALTVLHSAGLDGRIYAYVQVLAVLARFYYVRQHGRAVHRATACFFAGFEIFGHAWTRMFLGVIGPPRGCARIEAIFSKLVQSAYEGSALAWLDRASRSSHLRVLRSVRLKLFDDNADDFLNSEQSWDESSEGFPSDFLRAKRKAQRRSFIEPTFLYTDLQDALLYRGRVAYARPLGAVVVPPTIAKWPFCYTSEEVPPEFDLGTVGYLMAAELVSAPFVHFPNGIRGLRRLTEIRRFANCIRPVADALMETPLSNLSQAVATEIFVRARAARLAFNALKEMGGVDAETGRLAQMTFFRRFCLLACNSGTQPEGLSSEARCLLPLANMPEFAKAFGCSSPSKMINQPCDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSC1</accession>
    <name>A0A9D4PSC1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_020926</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSC1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026942"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="350" mass="39199" checksum="B5C0BDEA5880E962" modified="2023-05-03" version="1">MVEGDEELREFGEEMDEGPRIKHTCPDCPFETYVRSSIARHRRMHARRPLSCHLCDAHYLDQTSLARHLRTHEGGQQALLPCPECGTHFTRRDTLEQHMMMHAQPEKPFKCSICQESFMTYKEMMAHKSGHGRKAPYVCEVCGKGYLQLSTLVEHRFSHEEERRFPCELCGKRFFSSMALKRHGRVHTGERPAHLLAHKRTHTGERPFPCPSETCPQAFSTSSAAKRHFLNIHSKDTQKNAKNSRGQQASEHGGDGEGGTDEAGGTDKPAVQVQHICKQCGASFQSRAGLAGHERAHIVLRPFSCPVCPRSFASTGAASRHLRKTHNTTATAIRQSVVRYEPVGPALSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUM3</accession>
    <name>A0A9D4PUM3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_005157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUM3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033937"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="4">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="5">
        <location>
            <begin position="145"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7955932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76278" checksum="445B1B69095DF339" modified="2023-05-03" version="1">MVPYIPLEERRRIAELSLQGCSQRAICGLMNRSRTAVHRIIKAYRDRGAALDGEQCSGCPRETDSLTDSLIVACAVVDPFLDANEIRRELQLDVSPSTIKRRLRQGGLQGCVAAQKPHLTERQRQLRLEFARAVEDWTEDEWHEVIFTDEATFSTRWDQQRRVWRPIGRCAVSAWGALSKEGLGPLVPIDGSFTAAAYCRLLQEVLVPYALDGPFEHGCYLLQHDRSPIHTARNVAAVLENLAVRTLPWPPVGADLNPIGNVWGILKSRLSARRISSTTSDALWHSVSEEWERLRHSPEVVVTLYESMPRRVQAVIAANGKMTSYLNNVWQDVSQAVPSAAALAHYYNSTLPQPAAPLPEIPPWLKAQASDNRPLTRLRQSNRQVEQEAVVTIIDDSLAVYADAAIDSCVLHTRLVCPTLPETQHTCSYVTEAPFPSVLAELAAIRDGLTLMIPKVDCLSLNRLLVYTDSTQAVRELRKVSSSLDIASYVHRIIYSCACPVRVLWTRRSTLAQMAADAACHPAEVQHPLPLLRLGSKGVESPYYWLLHSFLGTLPVNDSSVVEESVEVPDVNETPEGAHVLAEFNEVVNEDAASVEDSSTTSLQDEGATPAAGSSDSSTPKNPGTSRKRKRPSTALQEILELQKPAEERCANLAQQRVAMQQQMVQLQKESNETQKDILTVLKSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVG3</accession>
    <name>A0A9D4PVG3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="204" mass="22627" checksum="187509A852D63803" modified="2023-05-03" version="1">MDDKSEPRENDKCMDQQGESTTGGMSKLRAQVHSGSTAPNDLCLSAACLGSAARVLAGLREDVAPCQDLYALSCRPGVPRRQHAVRHLVDLVPFDGDQASAELKAKRFYETCMEPRSLSQDALALLNYRLRQVGGWELVASSSWSLQSWDRDTALEKLHVDLGVSPFFAVGVADRTIRVRSCLRPRFDHSLLLRPQGARHDQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVZ0</accession>
    <name>A0A9D4PVZ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVZ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="427" mass="44093" checksum="15850A5FCFEC3C53" modified="2023-05-03" version="1">MAFAAPPPKAHCFILNAPEGSTVDDVIDALEAVTGPAGIKSLQHMGGVKFSAAASSENAATKLKSRGAILLNGESVPLVSIGPEIVHVSVFRVPLWVGDAALASALSAYGNVQQVHEPAFKGRPGVGTGIRVARVEMKKPIPNFLSVQGHTVMCDYRGVKKVCSRCRLAGHIGKDCATPRCTRCGVFGHTTDGCTEPCRRCGGNHATVDCVRPRSFAAAAAGEQEGIDSLSTPMGSHGEQAPLEEASNEAVASDAESQGDIADLPHHSGAKSTAHQTQRETEEDTSSETCGDLSSPRPGATAALPSGGHEDTSSDAGSSTGSADAPRSSMGRGTRAATRTDAPFTGLEKINSRAGGLTAQTRRMNLSNPLHKITGPVAAASSGDCAMDVERQAVKRVHPSSTDSEGVLESKPQKLSNALAQSEHTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWM5</accession>
    <name>A0A9D4PWM5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029251"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="12903" checksum="53278CDF982A6DCC" modified="2023-05-03" version="1">MVAGARSHLPQGLPVSEQHRRAVVQTCIELKLPICVQVTALEYLDRFLVQHVRDLREQLGAGSPACANVSWDSVMGRMREQVMLRMLSCIQIASKMFSSVRPGYGARGCAAFESAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX33</accession>
    <name>A0A9D4PX33_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044178"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="4">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PRO8NT" evidence="4">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7955983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44236" checksum="1DBA7CFBF5A6B652" modified="2023-05-03" version="1">MFPGSEVAKVFSCARKWQQLQSKRYAEKRKFGFVDAQKEDMPPEHIRKIIRDHGDMSSRKYRHDKRVYLGPVSVDINASITNRSNWSNQIKQHRRLSPAVAAVLTMFPVAVVWSCEVEMVLCENACGWATAKPSTTPPSHGSRTPDNTGVPLSGPIIQDEARQFAVALGTFGFNASAGWLYQFRQKNGIMWQVVCGEEKVADAENCEPTPRDCDDEAELDPELWNELTEKLLVDAAVTFEDYVDSGCAVATSAELTCEEIVNQLREQDCCSSDEYDAGRVWDNGRGYFQLECSLRRPDRTSGAARTYPKTSLGRALKYMPHAVLKLMENMPMPWEQIRDVKVLYHITGAITFVNEIPWVIESVYIAQWGKIFVLMDFVMTLHVAFVPKHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX62</accession>
    <name>A0A9D4PX62_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_018561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX62"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034815"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="399"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="716" mass="78885" checksum="5103D9A6E83019F7" modified="2023-05-03" version="1">MLTYPESTDFRKRRIPNRILCSYVAPVFLSPMLVLADNQNAMRFAFCSCLMAVYWVFESMPFVATSLLPLLLLPFFNVMPPGDVASGYVSEPVLSLFLGLSFALALRHGTSLYTRASFALLQCFGTRVRSLMLGFLGCTLVLTQVLGASLTAVLMVYTVECAMAEIQNDVIREEQFKAYAQKFRRRFSGGRGLMSNRRTKSEDRLSRISNEQARRRASGQVSIEKFESSVTTTARSAALTDQSPPQTQERQQASANKSPASSSVEKAKRRGTIHVNLNVDSASVPLQARSRSSLAATPSRSALDGSSPDLEPRKASMRDRKISIYERGKTLRPGEEDLSVVAGAIEPKKPISRKKSSIFGGIREFIKRRFTTSTYVDSSYLQERIAWEKERYTTIQKDLLIGIALTASVGSITSFHSNYSNIVLSKYYDNNSDRKELTTTRWLLVTLPVAASAVAFAWSLLMMGYLERYFRDCLILFITLAWCGSKILFAPEETLTEDKMLHAPTSLLLGEALFVALFSLPGKLLFWREAPPNDAYAGGRLASWSRVASSMPWGVLIVYGCVHSMLIASRVSGFSALASDAIRQMNNMDPVTIQLILTCTAALLTEVVSSTTTASMLVPMAVTLAKQSNTHPLYLAIPVAVASSTSLVTPVSCTAITVVVSYAEISIADLLIPGLMIKAFMVTSVLLSVNTIGEYVFNFDEIDYAAFTARVNYSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX90</accession>
    <name>A0A9D4PX90_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX90"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029140"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="273" mass="28621" checksum="FD170FA412E6F9AD" modified="2023-05-03" version="1">MVGQEVQVAHSARREANRLRRNASARHGSAFSLARRISACGRSRGGHAGQEGPSKLPKLSPAVGGRRAGRLASEVTTPVPAARRRRPKTRTETLATTAAPGSLDTTVAQRDTSSPAAPSSGGVASSSGILSVTTMTNAAPSPSSLSSEEDEVESMRWLAADREDQSDLASDGGARGTSALDGPFNSTMVEGGVPIHQVPSPSMTSTGGPSTRTLVPDTEDEPLADVPQPMASPPPPPESSPTVVTPPCPPRVYRHMQLREMRRVLYSWQLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYU6</accession>
    <name>A0A9D4PYU6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_007643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYU6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037934"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="17716" checksum="0F4738B0EF5522A2" modified="2023-05-03" version="1">MSGYGGEQHSEPLQKPLTIWFGATMLSAWTGSFCMGITLGYTSPATDSLSTSTGENADDLRSVSYSAWFGFLLPVGAVFGSVASAYVCQHMGRRFALLLSALIFMLGYATLFAASWSTLILCGRFLTGLATGMVSLCVPTYIAEVTLPAYRGTMTLPLTIYLDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZJ8</accession>
    <name>A0A9D4PZJ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZJ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051290"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="429"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113099" checksum="843DD4809CA7A2E6" modified="2023-05-03" version="1">MSLPTDEDALRGRREDQGLPRSPSREKHPTSPPFDDREAQDEGVETLETSYGSHAHNDEACQRQRASSDDEKERRALGNRWASAEETTLSNRTQQAPPGSDEPAPASSLSGAKDLVASREAAAEAATGLSAPQSSEQINVAPPSRTVEEIAPFQRDSCQGISDGVRFSTAAHQRPIWTPFVTSPGDDATLELPTWRPATAVTSPESVPPEGVAGAECEWYQTATSTAPTPAVLPPHAAFQPRDGGSVFSTALHQQQPSMFSDEPVTSSLHSTPLAPALKPALPAVQAATCSNLATMSSATSPGSRPEKSSDVWSGTTAMVGPLAEASSSGGKADTSTANVSQPEVVSCCVIGTTTVREFTQLTMSWFYSRQQVCGLFCGTGMLFVPLLVVLIILLTRRNPRTHLEYCTSAACTKALASLHTLLDETVDPCHDFHAHVCGRWDSATGGRISYVDESVQRTAGRISRALLDVDWSQTVPRETRLVARFYQLCSSFMVEPNRESLRADMLRPFAGFYDDLLKIQHYPDLLVRLIDLSLAQGVHTVFGVKLVRAGAEPSVVVFPGKTLEQKVRPSLVAPFDEYLRTLVADVAENAGSVPGTFDPHDLMQVDKRVERILTNEGSKNGRRHLDIPMLNTLNEALSSASWLAALNAHLPKSQKLIDNSSVTVDAFPSVQNVLRLFGDLPNHGVNYLYLNVLLDGLRFDYLRTLHNKSDIGILLACLQASAEAVWVTRNVVADLIFGSHGDGGAVTTDLFSVVRESLFTASGSFRWMGNAMQRRTKRSLSTISLRLHDWSDSNASVEASDALLAGMTPADFPATYMRLRKDQQQRFLANTDAKLAADDDLHLFGNKAQFDVEANALIVPASLRVQPLLYPKDVPPEFVAGTLGVLMAKEVHRAVVFNHTAEFWGSRERRAMARFEQCTRVLASTLNVTLTTQSIHLEEPSPYVLWMMAATSAFEALRLASRSFRGASNVAHYWKPAQQTFFRRFCLLTCGTQEDVAEDALTSRLFCLLPTANMPQFAEAFACPANYEEAFCVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q045</accession>
    <name>A0A9D4Q045_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_013648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q045"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054665"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="26449" checksum="8AC9D7D8D7202E5B" modified="2023-05-03" version="1">MGRRKGLTGSSPSYTTVRNEALKSGQPFVDSSFPADATSVYVRGQGPQLEWRRPSELCSQPQLFADSNVRSYVCHSRPANAWFVTVCTVLTHDQELLAKVFPDAKKQGWHAGSEKHPGVFRFRFWLLGSWIEVLVDDQLPVVDGTLYGCRSQIASEFWAPLLEKAYAKFLGCYELLEACSLSDALVDMTGAAAEHLELAVGGYARDSTLQEQLFSNMLTVLDNSCQAVVCCAISVARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0X1</accession>
    <name>A0A9D4Q0X1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0X1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042802"/>
    <dbReference type="OMA" id="ARFHVHN"/>
    <dbReference type="OrthoDB" id="6506779at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039458080" description="Secreted protein" evidence="2">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18099" checksum="E9EC6912068FBFF1" modified="2023-05-03" version="1">MQRRRPHEQGTFLRRRRREASRALALLVCLVLAQKAQALPIVDRFVQNVFEPDRLNRWFTLWEKVIHLARFHVHNIPRIIMMPFSNIHTMHGRAKDIRRGLSDLPLRSILGRVQAFTGFAGDGGGTVTGRNDYATESPASVKKAAQSLTPQPSVVRAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1L8</accession>
    <name>A0A9D4Q1L8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1L8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027402"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="218" mass="23658" checksum="C2F004EF1DD0360D" modified="2023-05-03" version="1">MGETANAAKGIGGGCNEADAWRAVEQRHQPWQRRGATASPVRGVGTLPECAAQQVCSALYVRVNRTQPLCACPAAFAEPCSESAELDEHTIKLVSNDRQGTFNLIKVCEPVLSVRRCQEPRDWQLLALQSTRTGRAHYLLVCRCPTGSRLLGPVRHTTPPYANIPGIRVYGMLCAQGPATSSLPPRDSRNFQKAVSGGNVKVTPGKRQRQQENSTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2D8</accession>
    <name>A0A9D4Q2D8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2D8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028048"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="401" mass="46143" checksum="7AD8A451E264853A" modified="2023-05-03" version="1">MISTRRYREVLVDTVFNDWLEALKCNQTLNAVRLPFCALKLEQWESLFQVLPMKANLKLTIEWNDMDYHLLPRACSVLREAGAEQQAFFETNFPPRNADIQLEYKGFSEIFAFMQSDTRSEFSRIMHQLPSASHITSVELQISMHAIDAALSSRIADYIRHSTTLKKLRITLFRVLFFPVSRSSCWEDIVTSLSQNRSVKELHIKLDNIEGQDTGMLAQAVKSNKNMQRVSFVPERSLDASAFFRVLAEGVKENVTLLSVVVDVSLVEKEAARDWFVVWDATRRNSGRLRNAALFVNGHRCDRTCAEALDWMHRHPALPKQVAELSSVHEPEAIAMIRDAVKSLEGMDDFMRFAGVVSRRVSCQWREDERVQLSDLNEYCWRRVRGYLRLSDVVGYSSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2S3</accession>
    <name>A0A9D4Q2S3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2S3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052891"/>
    <dbReference type="OrthoDB" id="6489114at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="100"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="568" mass="64312" checksum="5B9B3E38B29CFB00" modified="2023-05-03" version="1">MLMFRACAYDTSPQRDTSALRMLRRFMAQRGIPWPSKQSSPAVRPLGVLIDLAFKWQVPLWFSVRFARKSPKVSIPPAVIIGPSPYTLVWFSLHRDIVRRGAFQNHWRRLHDALSDAKNDSDSNTQRAQHTAHVDSTVLGQLANALTNGSEPSDEGKLRNVSQQFTPNIGYTEWRRLLQEHVLPIIDGNYLIRVSNSAVLRATDALFSRFTEDTLLENMGWFFARLFAPLADPSLLRDRHGAPHTSEEELPLFCAAQVEALFRLLVISLYTVPRFSTTLREDIGQLLQAIREVVADKVSGLPWLDEYSKQRAGRKLREMGTVLWPPDNMLSSEGLATVYSKVRQPSGTSWTVVDAWVQGREAINNLDQDEYDVVMNLPANMELPLVEYDYLRNEVRVSAQALSQPVFYFEGTRAMFYGGLGFLYAAEVVRALDADGARRDEHGVLAPNRTWLSPAWTEAVLDREECLPEPGGYFPEIPAVEVAYASLEKSLVSSGERMRTAQSAFSQRRLFYVTLCYLMCANQTFHPQRRPFAGDCNKAVANFPRFAEDFGCGADARMRRERPCVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2Z8</accession>
    <name>A0A9D4Q2Z8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2Z8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11047" checksum="8889D773DCAC36A5" modified="2023-05-03" version="1">MGANGIVHEVDGPFLGSRHDAEVCAETSACPADETIDHILLQCPGYDDHRRRLFGAFSRLGLPHLCLDELLFPSAQHSKVLQAFHALLDFFGDADLFTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4W2</accession>
    <name>A0A9D4Q4W2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4W2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050781"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35102" checksum="5E49CEC6E674A573" modified="2023-05-03" version="1">MHPQNDHERRRARAIALTKNHRDDPHAYYVDVAKYPHMKNAYAAAVLRASTGEITSAGSIRCKTPAQAEEYAIAFAMHTTGCHTILSDAKTAVINYSHDSVHPTTTRVLTALTQHGRMTNNVTIKWFPAHTGDLNEPDGPNRNEEADREAHALTRRGLPSLPLESEPATDPDSEDVNYAITQYGEVLQWYRTSRIKYPPPHRDLTRNKATTLRQLQARAIWTPVLAKHICPEIYHTDTCQRCGRARATQNHILWECLPPPPNTQNGQIPEEIDKKITSEEYETQRDTVRHVLELLDLQKPGTTDRSQDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6D5</accession>
    <name>A0A9D4Q6D5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6D5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036872"/>
    <dbReference type="OMA" id="DHREARI"/>
    <dbReference type="OrthoDB" id="6501914at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038693752" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="67"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="25691" checksum="E56D5F420269EC30" modified="2023-05-03" version="1">MHRLGASAGFFVALLTATFFRLDTASALQSRCRPAYRNLPGGVIHTACKGPNPKCKLDKRLTGLNEQLKDRALQIQNNYRAEVAGGARYNYKQAKDMSELEWDDELAEVAQAFAEQCVYSKHDKPEARITTKFKSVGQCIGWSVDTTKQTITEVDPWIEEWYREHYNYNPDFVSSYSTRRATGRVDRFAQIRCLPEYKNLPGGIIHTACEPPNPLCIIDYSLTGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6K8</accession>
    <name>A0A9D4Q6K8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6K8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058252"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21952" checksum="A1D02A024749E428" modified="2023-05-03" version="1">METTGDSRRASPDPAATQAVSAVSFRLPRFWPADPSLWLAQVSSQFVTARLTAQTSKFHHVVSALPPEIASEIRHLILAPPETNPYEKLSAELLKRTSSSERQRLQQLISAEELGDRKPSQLLRRLQQVLGDFLRRFDLVRSGPATRALPTAPTFDRPQGARRCSGLVAGKARAACRLRDGIRLPNHVSDRDHFDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q874</accession>
    <name>A0A9D4Q874_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q874"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="21873" checksum="3DE349A9FD629890" modified="2023-05-03" version="1">MAPRKPTRREPAACRQGSKRPAKRVPTAAWASSLGAATTQASGTQRATWTQPRGQEVPSFFFSEGTMEGAKTGVPRPAPAPCPVAVPRLHSLGSRCGGRGGPAAVTSRRSILCQVRRGGALQEPLHGDLHVARDTPAPLGQRSDADLAAICQTSTVGRSPVCGAINRTADVLTAASPAAVSNRGSRRRRGDNGRRPAPRTLVPPPPSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8G9</accession>
    <name>A0A9D4Q8G9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8G9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10153" checksum="62506FB01373FB8C" modified="2023-05-03" version="1">MSFRSLQVAIDAVDAFLSGIGLTLAASKREALLVHPRASTRFSTPGLSLRGLPIEWSKTVRYLELTIDNRLSWRPAVDDLRKGNRKVLSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9A6</accession>
    <name>A0A9D4Q9A6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9A6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042545"/>
    <dbReference type="OrthoDB" id="6482754at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35934" checksum="6C90F6F7806239C7" modified="2023-05-03" version="1">MDAENYRFVDGLWAHNFLLEDILRSAFSYKPRPDDVFVATYPKCGTTWTQYLILSILKKGDPPKTSMDFMLASPFLELMGAEAAEKMARPGVLKIHLPFNKAPYSEHAKYICVARNPYDVCVSFYYHTKGFTPKSVKDVSFAAFHEMFISGKLSWGDYFDHLLSWYEQRDRPNVLFLTYEEAKKDTARWALKIADFLGAEYGEDLHKQPGLLHKVLGACSLENMRCVFNDSMPNVIQDLLNLPPAKALKSVEAYRKLNLPPEMHESEGFVRKGIVGDWRAHFTPDQITKTKAWIEEKTKGTDVMQLWSDIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBA6</accession>
    <name>A0A9D4QBA6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBA6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10864" checksum="DF8B5C55D85ECD9E" modified="2023-05-03" version="1">MQKRSDLSAVQKSMVIGFRAKRPTMAAEMRSGELTSYRSATDHPDERKGYQRCLPNNCSANVAPFGPPPQMPGSYTYVDCCSLATQAGICTLVPRLNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBG3</accession>
    <name>A0A9D4QBG3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033548"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="26661" checksum="7E7B569E0AFEB2ED" modified="2023-05-03" version="1">MSFVATLQKYYNTTVVPVDFKSDAEAARLAINAWVEEVTKSKIRDLLPFGGVNSDSVLVLINAIYFKGLWDKQFNPEATTLEEFHVSKEAAKKVHMMYKQADFKVNVECGDLNSAAIEVPYKGSKTSMVILLPHEVDGLPHLEAKLTASKLSDVFMGLRTAVVQLSLPRFKVELSVNIKNVLQSMGIQDLFSRKADLSGISGEKDLVVSAAIHKAFVEVNEEDEHYLADLDFIGPTHTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBZ8</accession>
    <name>A0A9D4QBZ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051077"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43808" checksum="9476CD4647D962C1" modified="2023-05-03" version="1">MAKRTEKTTGASDLVQCGECTRWCYLDETAFTSLADAEEASFVCKLCEKVKAAAQRMESCIEELKGELKVERVKRIELQAQLGEARERGEATASLVEQMEADLRKEQERRAELEERVKVLMALDSGPEQWEAKGKGITEFQAETGKKGDLGAAVTHVGTGDSRRKSYSDVARQASGGAKQGAPAAGSLSRVGDTQRTGDQRGRTGSQQSQAGSERLDRRRVLVVGDSNVARVKQGVLTTVKADRRVKVEAQSGKCMTDALAKAQEVVGDSMEGENLVIIHAGLNDVLKGKSQNLQRQLEDGVRKLREASEGVHVTICTIPEVWGQSGGMERRVIEANCVIRAMSRQLSYSVMEVNKDVYEPGLRPFAQDGIHYSGATGRRVGNRMGRQATAFLGGPSALRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCF8</accession>
    <name>A0A9D4QCF8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCF8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039183564" evidence="2">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7973148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="293" mass="31661" checksum="A3BAB8D5DE26B299" modified="2023-05-03" version="1">MGPRIFFLLGVLASAKGGQFSQRLDTPVAAYGWVPLVPVSTRPVSQNGQVYATTPYQENSPQVYQQVNGANGDAPRQLSASSPQSRTVTASITWPPEQPGQLPQGEVVGPGQPGEDIAVPETDPPVLDNSRPEDRVVETTLKTPQSHGYVVALVKKPNHLKSYFKSKVPGAVRDDQPAFFVYVPPNQRAPTSSAPQLRANNRGTSQASGVPRFLRQPFSVTTLRSPTVLVYVPPELSAPLVVPANPFLNALLEQSKPKTFLDSPLNAPWFSQSLEAPPEEIIKLTLSQAGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDK7</accession>
    <name>A0A9D4QDK7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDK7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030330"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="299" mass="32544" checksum="082AD302A1C3D679" modified="2023-05-03" version="1">MVKRTGKTTGTSDLVQCGECTRWCYLDETAFTSLADAEEASIVCKLCEKVKAAVQRMEACIEGLKVEREQRIELQAQELGEARERGEATASLVEQMEADLRKERERRAELEERQYEAKGKGNTESQAERGKKGDLGAAVAHVGTGDSRRKSYSDVARQSSGGAKQGAPAAGSLSRVGDTQRTGDQRARTGSQQSQAGSERLDRRRVLVVGDSNVARVEQGVLTTVKADKRVKVEAQSGKCMTDALAKAQEVVGDSMEGENLVIIHAGLNDVLKGKSQNLQRLLEDGVRISFEKLPRVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDM0</accession>
    <name>A0A9D4QDM0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDM0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10821" checksum="0D21EF81F5E6063E" modified="2023-05-03" version="1">MEPTGGNAGVQKRRLREDIEKALAEYGEYSHEEVDEVIKILEKIGMKATKGFTVIERSDLLEKGMPAVVAGILMKAFEGIVPQLFGAEGAQDDWKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG21</accession>
    <name>A0A9D4QG21_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG21"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050816"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7982133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43071" checksum="0F2A0FAFE78DA66A" modified="2023-05-03" version="1">MHSEVEYAVFGALMCANLGFGLYFSCARRVRKEATTEEMFLGSRSLRTLPLAGSVLASMLSAIGVIGFSAHYYAYGFHYLWNFMSAPLIAVIVSKMVIPVLYQLKVTSVFEVTIGAVALFTASVAVSTIFNASLSWSTVGIGIASTIYTSLGGMRGVVWTDCVQSLLILMAPITVVTKVIYDSHYQGDRLQPASDFNIKEYIFDASLDFTKDENVWACMIGLFVHSLFRSGMDQVVVQRYLAARKLKEAQRCDMNTMLPYYVKENLGDFPGFSGLFLTGVVSAATSTVSSIINSQAAVFYVDGAAVGTLVAGSLQLWLMFGKIALDVHSPRMGVTLDYCPINATFPMTNNFTFITDEAEIPAKVEEDEDEKDILRHEFRRDESFDSNESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG52</accession>
    <name>A0A9D4QG52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Voltage-dependent anion-selective channel protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_014390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037546"/>
    <dbReference type="OMA" id="MAPPCYA"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000001">
        <property type="entry name" value="Voltage-dependent anion-selective channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7976459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30355" checksum="3208BE40E4CB01B7" modified="2023-05-03" version="1">MAPPCYADLGKQARDLFNKNYHFGVVKLDCKSTTHTGVEFNVSGTSLNDTGKVNASLETKYKVPEYGLTLKEKWNTDNTLSTEICTEEKLARGCKVAFHANFAPQTGKKSGALKAAYKLENVHLNGDVDLGPPGPVVHGAAVLHYQGWLAGGQVSFDTTKNRLSKTNFAVGYQAGDFVLHTNVNDGQEFAGSVFQRVNPQLQTGVQLAWTAGTNATRFGLGCVYDLDMETSVRAKVNNSGQIGLGFTHRLRPGISLTLSTMLDGKNFNQGGHKLGLGLDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGH9</accession>
    <name>A0A9D4QGH9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGH9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029745"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18128" checksum="E3F2A7E40C8CB26C" modified="2023-05-03" version="1">MTEASTERWRTSAAKKRSLQLYLKYKLAPDCEPFYRGDRESALLFQARTGSLNTQQRRWELFDADPSCRLCGATEETIQHIMMDCPRLGARAHPTLSLAEYLGLSDDSVDTRVEHNESAKRRLKLWDCAGKCTNTPTESSAATAWRRARRADSTTLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGI6</accession>
    <name>A0A9D4QGI6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGI6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="16974" checksum="6F9257224899D6F0" modified="2023-05-03" version="1">MSTKRETTIDLYMAIETLQAAWMSGTASTITNCFRHASFGVNSGGDSKVIGAAANEGAARDQDLASWDALLDAGVLPDCDTFCTYVSADADAVTTEELTEAEIVRAVTGVVNDDSDECVDDSPELVNPMFRRPRKRWMRQTCCAASSALTMTARTNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH11</accession>
    <name>A0A9D4QH11_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_006285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH11"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029519"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="89"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7982658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="299" mass="32455" checksum="E9EECA7803C2A665" modified="2023-05-03" version="1">MEVLQFYELSNLNDSVTDGADNTSVLQVSIAVATNMSVDVDPVAANGSGALSSVSSSGSTSSSLYEVPVDIVVLLSFCYGLVSFVSILGNVLVLWIVASSRRMQTITNLFIANLAVADVIIGVFSIPFQFQAALLQRWALPYFMCAFCPYVQVVSVNVSVFTLTAIAVERYRAITSPLKARFCSKATAKLLVLIIWLSSLVVASPNALALRVVLVVDKLSGLRERPFCVNAGMRPLTWKAYNHALVCVQYFLPLGVICYTYGKIWKKLRQSKAPGNMETVRDANIVRNKNKVGSPALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHD7</accession>
    <name>A0A9D4QHD7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHD7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035698"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11046" checksum="0C514DD321F44EAF" modified="2023-05-03" version="1">MEKRVAIGLYRLCSSAEDRTIAHLFGVGRSTVNVVWRQFSTAVGQQLESQWLCMVRRAGMADHAREFFAVTGFPQAVGALDGCHFPVSPPKKHETGYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHW9</accession>
    <name>A0A9D4QHW9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030810"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="14776" checksum="E6F84F38D1CE5EF2" modified="2023-05-03" version="1">MVKTSWVEITATCVQNCFRKAGFADVGADADPEASEEDHSGGDLWQRVVDSDMGGRDICWDDFVMADDDANTAEPCTDEGIVNEVRGKSDSEESDDDDDETLEPAPTSVPVAIGYIDSLRQLVYAKGLGEEHAASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJ40</accession>
    <name>A0A9D4QJ40_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJ40"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="118" mass="13487" checksum="13FF69687152DFB8" modified="2023-05-03" version="1">MLMNIRQVRRRRFTRSENTYEAGSSSSVPFSWNSLIRESLLQTSWPISLSADSDDDEFDLFNPRRLAKAKPLSDAVSRPHNASGAQWGNVQHLPFHRCASSSPRRVNKSLRPSVLYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJE9</accession>
    <name>A0A9D4QJE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJE9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="63" mass="7218" checksum="79EA0B666D63EC7A" modified="2023-05-03" version="1">MAMPAEGETFPTGLLRLTCTQDKIHDVCRLLQHLNTYNEVLWDVGLQLREDPCDELGYLSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QM07</accession>
    <name>A0A9D4QM07_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QM07"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028483"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24072" checksum="333B7F6A15803910" modified="2023-05-03" version="1">MHPKYHAGRRRAKATALLRRQDHPDTCFANASLHPRTTALSRAFVTVAKKHGNATAEASAIALAIRDAEAKDQSAHILTDSQDACRLYMAYTTSLCDEVDPYTLRPGTATTSKISAFPEVSHGGIVNYLVFSTNLVTVGEIKAYKSMESHNHFTSGWVKSLSAKELRDRKFDRACRERAAFGFINTHRPVLGAVRPPLATFRDDVSARSCRAAPACLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMD3</accession>
    <name>A0A9D4SMD3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001604">
        <property type="protein sequence ID" value="KAH7932335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMD3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039515"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53135" checksum="794AD390FF6605CF" modified="2023-05-03" version="1">MGKNSKDKKTMKGKSSKGTGNRPQDFLKGDRGTTPKCSLVQSETDSSAEESGESRDTTRDERTARQERRARKMGKHTTFQKPQLNEESSEEEDEHNTRKALATLSNAAEQMERSSEQEFPPWRSSKVEAPGDGGISKATPLQKLMKADRKLFKAISVIATETAENETVSSQLDLIINEVSKMKSLILEATHEVAGLQGELRATRGATGMGQSPTPSMADVIRDTAQWEPDRQPSPPKYRESIVVKSAIHGTDELSKLITQNIDPCSLGLRDVETRPVRDGVVISSTSKEAIASLQKELKSNDATGHAIEVTQGKKRLPQIKVVGINEDLSDEEMQACLLTQNDLRCTADDFILAKTWKGRGGKTACFDITKRASEALRGKTHLNIKWTRCRFFDNTFIARCKNCSQVGHVEKFCGEASRCTDCGGAHHFRQCKNHQKNCSACERELPRAKRDHSFLSLDCPVFKDAQARRTRELIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN40</accession>
    <name>A0A9D4SN40_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13 DH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001435">
        <property type="protein sequence ID" value="KAH7932464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN40"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035415"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47112" checksum="43D1B36E8C6A60A2" modified="2023-05-03" version="1">MLASRPKQSSGVKWESKKETKTYYKAVNAKESNQLELQYQRYNNLRRLDRDPASVLMVNGYEVNFKEMKILSNPKKDLRRLARPGIWATYKKSLHQTMIHAKLHILQEELLEKDMQLTKGGLKEIAEQFSEQGVKDFFDMLHFSPIKLHLSFSLSADSKNHSGGSLFNLLLQSFGVTFTEIQDAVLKLDYFEKSNTYLTMHQLIHEASSHYFRQTLKQIYVVVLGLDVIGNPVGLLTGFTTGVGDFFYEPLQGAIQGPEEFAEGLATGVRSLIGHTVGGAAGAVSRITGTLGKGIAALTMDEDYQRRRRLEQNRRPNDIAEGIAQGGRDLVMGVYEGVTGIVTKPVAGAREEGVSGFFKGIGKGLIGAVARPTGGVVDFASGSFDAVKRATDVVDEVRPVRPAGSLGRMESSGLTTLWKRKATGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNK0</accession>
    <name>A0A9D4SNK0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_006757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNK0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026655"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032496"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7935370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="681" mass="75041" checksum="A79419BA2F048BCE" modified="2023-05-03" version="1">MADVYSQGMVSVLNDLRRRRVFTDAEVVCTDDGSQFPVHQVLLYAACPLFREPSPGGNQPGPANTINVAAVTPGAAAALAPADDVGAAIATTKQGPAAPTEAGGGEMRNVPVAGVRGDVMAALLEYVYTNKVTVNSDNVLSMLLAAQRFQIERIVQKCHEFLTKDISVANCVRILEFAREQKHPSLVDMAVNFISGNFNEVTKTNQDFVRISYDDLKALLSSDELNVADEGKAFSAAIKWTSADAPNRHRFLPSLLSAIRDVLFVIGGWSNGSATNLVESYDCRANRWLIFPNDRDIMPRAYHGLVALDGLIYMIGGFDGSQCFNCVRCFNPLLHRWTERACMHVARCYVSVAVLEGKIYALGGYDGDRRTNTAERYDPASNTWSLIADMNDQRSDACATVVDSKVYIVGGFTGQQVLNTAEFYDPKVNVWTYIRAMTVPRSGVRVINYQDTVYVLGGFNGTNRLSTGEKYDLLRDRWLELPNMHTPRSNFAVAVLDDLLFAIGGFNGTTTVPFVECYDSKTNSWRRVTDMNINRSALGACVAVNLPNSREFSVVDKLLVIATLSMVACVTLGDMMRKSIVFDASTPKVFYCPQEKPRALDKMIVKARPVEKLCEFEGKGLPKGYKSDCYNDVDESEYACAEKQRILLRINPPNETDTTTTEAATTAKPSKKSKSFKVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNP9</accession>
    <name>A0A9D4SNP9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_018004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNP9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027416"/>
    <dbReference type="OMA" id="CRETAPK"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7936092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15136" checksum="F6B716167C1ECC78" modified="2023-05-03" version="1">MSQDGSNASADLSQISGEDDLPVNYDYEESAWRFDLADLIPRPVVYGATLLLGLVCNLVIVYTVARLPRMRSISNLFLASLASAHLLIVLLCVSVKFGQLFSYTWTLGELGCKLLLYTQHVSMICSVLNLTFLNIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP42</accession>
    <name>A0A9D4SP42_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP42"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24212" checksum="E7A007ABD22F9AE4" modified="2023-05-03" version="1">MVIVTTPESHSTTAADDVAQASEASTNPTERITAKEDGTQRETETPAGVTQSNVNAASPNTCDYFTIGFESPLRGQCVQFAQPLPDVLVCSGCRFIPDKSFQLPCSHTLCLSCCEIYFVDTRRLTGYDDASGEDSTPIVWCPKDGVPRAASDLQFVALNLEQVRGEIAFCVNSVSGCPFKSELRHVEQHYANCAFGNPVCESCRRSDIPAAAILFHTFLCGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPR3</accession>
    <name>A0A9D4SPR3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPR3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="24188" checksum="514D4AD88CC7292A" modified="2023-05-03" version="1">MTSVDIDLAFDFLSFATAEQLRDFDEKNIPWLPPMRGQRSTEQAVRALRRTVESCTVLEQRLERLAYFYCWMVPLQVLRPWTLMIVGDVFKEVWFSEATLLTRIANAIRDLGRETTFVTAESETIVYGCVLVQDTEPRVPAHVICMCCWRSLPFMAVYAPDTKVLPLLDVALTAVLGCDTEPLLCGLHEFLCEAYNIVCNYVERRIEQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPX0</accession>
    <name>A0A9D4SPX0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPX0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043955"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="282" mass="32445" checksum="08FA2E8707400E73" modified="2023-05-03" version="1">MASWWLYNQAPPTRQHYSSEFPSRASRWAHQFVSTSFKDNHRYVRRKRPLQPQECHRRQRPTHDYGNASLCLLAGILDGVYERGDFEDGNTSSRESALRSPLPYPGNLRPTPYVVSVSDCSLLHRRPIWFLQPLPATHFCAACNVVPTMAFALPCGDILCECCRDSITATARLQISDREDGAKPRDGVCPLDGVPFVESELVTYTGYADDVQEEVVLCANIEHGCSYRDELRRLEEHLLYDCRYSPKTCNFCKKKNIPECELLLHTLRCPLRPRRARVLRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV91</accession>
    <name>A0A9D4SV91_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV91"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="69" mass="7093" checksum="4FB30AA301758F33" modified="2023-05-03" version="1">MTLGVRQVGATVVIAAGPVRLALTGDPSNGPSQCATRAFRIPRTDAATTGRDDEARPTSVLRGLDGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW01</accession>
    <name>A0A9D4SW01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_008949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050425"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SERINE PROTEASE FILZIG"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_SER"/>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
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    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZM7</accession>
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            <taxon>Metazoa</taxon>
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            <taxon>Acari</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="366" mass="37767" checksum="A117C5A23BEEEAC1" modified="2023-05-03" version="1">MASQPSPHLSSPHQPHSRAATKRCGELPTQGHHACVPHTHPKGLQDSGRPEKAPQPGKARKGEASAMTAPPTTPSSLSGKSAQQTTAAIFSPPASSQTHPESKQRSPQNPLLEPTGSSNREECCTQHDKITFAPSQQESETNSRGSPPPQTSPSWKHTAPPSCYPADPPADSSSEETRLAGSPLPSFPAAADVTRPPQKKAASSLGTAKTAVATLVPIPATTDTMESTVADEQVIPPDAADAAAKQATESARKGKQPPSQHAAGGGSIPSCVMGTLAVSDEDDAFPSLPSTGAPPGTPLCAPLVPAPPRGPPQAKAKPNGPPQPPATNTAEPRPSPKRARSAHRVRPALRAVLNYIEAAQLADRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T087</accession>
    <name>A0A9D4T087_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T087"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041314"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7963104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="500" mass="54515" checksum="C0B8648F76B9DD1F" modified="2023-05-03" version="1">MQKAAEVWALFGGRHAVDTELQKRRDLPEMDECEETVYRGITWPATPPDKCAEMDCPNWNVGIMTWCCNSRGYWKTQSPNTAQCVQPSVLLLKSQQKYLADIIETVSDFVGNNSLEVGGDLVAIVDLLDMGVARSDTGDNYPGRIASAAQALRVGGLTASTVDALLSRDKPWNEVPVQTRHSCATTLLLIMDVAGIILSAASSEQKILAFINFQMNIISSTTTHIANQTMLLPAPSNTSDRTYSTAQLRIARNSSGADEDSPVGCDGDGGAGDVVIVFTEFPRLDKLLLDDGVDVEDPKQELNSPAISIRVGSEAPGLVLGAHVELALPMLHHDAENPTCVFWDTLINEWSPDGCQVGRRNSTHVVCFCQHLSNFAVLMDLRGALPRDERSTLPLRIITWTGCSASVLCLCLCVAAFGCFRSLRNTRTSIHLNLCICLLVAEVVLMFGLDQTKHKVEVATICNELIYAFSTLVVLIEAGYVKPPRKLAGLLYTRGNDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0A5</accession>
    <name>A0A9D4T0A5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0A5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049674"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="723" mass="77014" checksum="889E52DBF8115371" modified="2023-05-03" version="1">MQRLAEPSVPPTTNDAPPVSPASCCATAAAVPTLSLSGNVSRPTPTTVDQPAAFPNSAHAPATCNAGSVLETPSSTTLPPDPKSVNTASASQSAAHDAVPTGSSPGILKENSLCADKSVLKSGVPLVPTVLPSTIAADDSSTEMDFAASQGNEDNTSYPEGSWNTVRANRKPASTARPRTELITVGIQLPPGTLTPKLPLYDLLASIIAAANLSPKTSAEVTLQAKPAQSLVFLKTHSPLTAHLLLSLTNMELNGKPITIKPYAPNPPISCLGVIHNGTVLTNALSTALRPSAAAVQRFCPQILLLTFVPNPGVSIAKSILIHLSTPPALSSLLSSGTLRRTTQPCPPSSSTHEFRSPPATSTPGSYAAKVKGASPVYPPSSNNTPSPSMGNESRSFDLRLAMLERNQREQQRVSDELQQKIHALTQTLETTTSSLTSELAELNKQLATLTAPTSDFHVAKLADMVETTTTAHHTRLVQLETSIVRILSALETQSKQLESFASMLNSLQDSLPPAKKKERGPLSTNISSPALSCPIFFFSRRLGRPAPSRATVPTMLRRARHLRPFMYAPTFPLWGYPQTLKPGRLLHCLAQERHLTLLNAPDTPTRAGTASQRFTTPDLTFSRGSLPFHWQHWHPAAVALAFNTLFLTLILTFSVYGVVINVYNALFAPSRITSNSPPALMLCVLKSWLTAHPSSTLVGTRCVTASTPPCTRDPHGLSLDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2E8</accession>
    <name>A0A9D4T2E8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2E8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039730"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="299" mass="33364" checksum="D2F752D0FFE643C3" modified="2023-05-03" version="1">MTGRSNKTVNRIIQAYRKEGRISDAPHRRHPRETTAAQDADNLDAAKASPFSTAREIGAAAGVSASASTIKRRLAEGKLKSHVAAQKPRLSLSNKTAQLRNRTLLFSDESTFTTHWDQKQCVWRPANSRYDPLYVQEVASSGCTAVNVWGAVSRDGLGVLHRVEGPLTSARYCDILDYIMIPYALDGTFPDGDFLFQQDLSPVHTAKVVEELLNMRGVRCLRWVPKGADLNIIEAVWGRMKVSLCKRGLHSSSADELWSAVEEEWMRLQNELSFVDNLYASLQSRMQDVIAVQGAMTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2R2</accession>
    <name>A0A9D4T2R2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2R2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21418" checksum="EBD812330B1C0BD4" modified="2023-05-03" version="1">MYAMEVGYTMKDIRYRWSDGDTSVRIAKEVELPQFKVLGHVQKAKEVALTTGKSQSQAGSYAAHSPKYPPFPFPQARKGVGIGGWLHPLGISSAHRASASFRSLAPARARARSATSEGPPLAQYGVRSRRVVVRSGVETSNANQCMPAGSATVPDQFFSQSIDRRYGPNLAERDLSSLFRGRMGSRELFRSEVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T314</accession>
    <name>A0A9D4T314_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T314"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036940"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038910794" description="Structure-specific endonuclease subunit SLX4" evidence="2">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54923" checksum="8B1B6B49012E2D34" modified="2023-05-03" version="1">MLYWTSRSKACILAFLHYVYSGVLDLNNDDRRLHLDLRGMAFRYGMEELCEELKDRYFRNESEQDDAGDGAADTSLDEILSSFWLEDDSGNGHREEEPISDDSDNVESLEEVCDFLSSQHPQKTEGAEHSKNARANASETLPVLSPPRTSLEQTTQPTSRSLLEKSSAEASQQVRRRPGTPFSAPAPASPVQSEDEQAWTDLGENGHHLDEGRHDDSRGEETDHLEEGAASAHDDSDSCSEELFGESNDSASSVGNATDGDEHAEDRERVPSREEAKRKRDSDDDETAAQDGLQGSGEKCKDTDDVWDCVWDGFDDGAQQDAAPPERRPSSASRWDRHSPAAAKAASVEEVPREMLDSFFFEEQGGADKGAAPTGLEHTPVSLPRYLGAPSHAYTPVTPLPDYGAMHTPELRDQLQQFGVRRLPRKQAVNVLNRIYDETHPLVPETPVRITFPRRGMNAGGDRDYRSGPMLTSGRPEPFSGSSSANEEPSHYSVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T337</accession>
    <name>A0A9D4T337_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T337"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033384"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="18184" checksum="DB4CEE65C8D0ECB1" modified="2023-05-03" version="1">MLRSTADHHELYTPRDAMIAPLSAPWQPAISAVAVEHSPAPQSRVTTRVPAPRYDRRAQRTPPRRPTYRYDIPDEPIRYTRANDLLMSLIAIRVCEARVASWYAKRGLCPPDLQFICGLLQQSVGHCRRLRRILSSEWWRQEVKECCSGSDCVDLRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3K5</accession>
    <name>A0A9D4T3K5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3K5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="303" mass="32909" checksum="81E75BE666B81D08" modified="2023-05-03" version="1">MPLEEMVFGEEISRQEDEASGWIVAHSRKKQRQDFTPGDSPGLSAGNSAARPAHPKGPITSSSPRRACHDCLKITTGLSCVQREAWMCARNAEAYAKVKQIRVGETLHEVSTYVTPPGDTCRGVVRGIDPELSDDRLGELFVHARNPKVLGVRRIKQTPTVIVLFDGMKVPNYVMCGTNMIRCTSTDDKSTPVEPAENWDIARTFVLPLRSSPARTVGSHRPLRITRASRSAPSVEERIRRQIGPAKAGTRSPTSFGVEGDDAEKQTSSAGSSCHSKLPGSESTRGADLILLGRVRVTALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3M4</accession>
    <name>A0A9D4T3M4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3M4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="194" mass="22192" checksum="43B3B535D9926797" modified="2023-05-03" version="1">MTEADLDGVCKTLSEMSVEEVRSLKEANIWWLPDIASLSKPEAISSIRNAMLSLDSTASRASSVAWLYCYLAEKNHMNSWRAYFLNESELSGKFTLHQRLMSALAYPGVSTTYENVEREDAVYVGILSTYADTSSPDHDVICLCIPRTLPYVFVHCSRNRNRIRVILGGVLRRPSLWFRDFRHLREAFDYARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T403</accession>
    <name>A0A9D4T403_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T403"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35303" checksum="AC99093FB119E643" modified="2023-05-03" version="1">MDKAAETKEETPPAAQSRPVLPAPIEASRSAWRLPNPRAMPLAQATAPLRYQVVSQQVTSTVHHHTPWQWAEPLCLVRVKTVRDGLEVKTNLKRIPIRQATTTGLIPSQDGDTNTTPLYDTIVSALSRPFGEFAAGRFFNLPETLDMTALACIVRHFEGSPSRGRDEAPFLRCALLGELAMTANNVKKLAPDGKVLCVDLGMYTKLASGAKALGNSCEMFMPDHYGVDTAVVPIYITGSGSRWVAPYVLSFVGTEYWNLKVYYELKCEENVILVLVDFEHRLKSSREFDVVGEDHLIPIVGASTGNLDHIAGVSMRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5I6</accession>
    <name>A0A9D4T5I6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028102"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18540" checksum="17A73AEA0D624088" modified="2023-05-03" version="1">MRRYKAIEAPDKGVQTVLDARERRVCSGGRWRCGNGVEAMCPRVVRHSERARVGTPPARLYRLFQGRTVADADRRANGACLPVPAGTRLCACGAVMVHESHAQSKLHRRRTGHTLPLSRDASEERPSEAARAMLARAAQAADFAQWLLTIATGHAARAASGTFLGGATWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6P0</accession>
    <name>A0A9D4T6P0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_020203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6P0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050183"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="213"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="744"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7976826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="854" mass="97124" checksum="EDA3032C876DDBBD" modified="2023-05-03" version="1">MRDKRRRSSLARHSDRRRSRSEERYEPRSASVSFDDTLSERPRRSSRESTRDGSSSSGEYEIVEVYNEDSAGDDDRWDDEDKDKTSSGSDSYQQSQAYMIIAAVMVASAFLGVLMKFAFTPSHSGHSHGLRRVPGRVLAEETDATTPFDATLTTSKINISVIKELATEPKSTTAADVTAPGPRKAAFTYECRTDACLWQSRLIYDKINQSIGPCEDFYAYVCSNRWYNNDLEVQSRPYVVSGPGLLILDIAKFLLQQKMKEQSSSTFITHSSMLLRNCIQVRNSSTADNDWQDIKKVLESYSLTNWPFMTDPPTVKFQDVLKLVDKRLNLLAVVHVTLRKRFENEGYMLHLDSPKLTMVRHQMTFLDEGFQEYKNCIKRAFTLLGSKVETDHIADDVLEFERKLDEASLPPKRFVSILNSTVSIVNLKRTGKLEWDAYLTYLQPGSEKVIVINSAFINKLSGILTSTALSTLLNYIGFRILVLLSPLLPKQAEFLVPLSYDDHIHKYNARLQACIHLTERLFPYGIRKIARAAMGKTTMEQIAYDHNLDKMVSSVKGVVSQTVARAPWLTQSEADVATQKIESLEVDFIGAKEHMDAINAYYQSRVEVSFAMESAVRDYTSLLNETMSRYWLSKDNADYDARYHVSCLRPGYEYNAGKNVLHVPFGVVALQQRVAQSAIPAILMPYIVPYLVEGTCMYEAIDVRGSTINVRGMPETWWSGETLVRYRQQQKCFTQNYLESIQRFMAEIAALQPSFEAYIRALVAPHSMQRNFRIPGLPDLTPEMLFFVNLAASHCDPVSSQGLTALDKRRLRYRIALPSSLRVNIPLRHFDSFAETFSCTRGTYMNPGAKCRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6R7</accession>
    <name>A0A9D4T6R7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6R7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28546" checksum="734AB02164B78A54" modified="2023-05-03" version="1">MASASPAAMDDDEAERKKLRLEENLLDDKTSTYNLSDEEDVGEDEPFTLVAYKKKRAEGIPVVFRPTAEGASFWKATRKVKLLRKCVGMSSFMEENRALMNPLQTLRLFILYVIYLSAHRNNSSRQTPREPPRAHPRDHSREVHLSTPTYASKLRTPTRPQPESSRTDSASVRPSYNIETSRRSQQASETEPFKGDHASASVMQLILPMLFAALQAILSALPEANNLPEVKALLPLEALLYQQSGSDLRQVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6W2</accession>
    <name>A0A9D4T6W2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6W2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="208" mass="23740" checksum="4D9E534D9BE1F1DB" modified="2023-05-03" version="1">MIRSSCDLVQLLEGGGLDCARFAFSLDVEELFYSIPHQGLFSAVRETMERLPNTQAARRRQSAKINEVDDLLASNEFDLARLRSILQRLEKSTDELVKANEALHAEMTDDEVLADFDSVLEHEDRAAGCVGLLRHHIQELTLRSSVLSRPNVASWIAHLPASLHKRFSNWSVVRRPHHRKGPLSPVVTCDERRVSKRTTYTFGPRQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7H7</accession>
    <name>A0A9D4T7H7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_008276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7H7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038906"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12313">
        <property type="entry name" value="RRM1_RRM2_RBM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7976030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30556" checksum="0D38F73375779F43" modified="2023-05-03" version="1">MRCSLHYSIPKEGFGGGSDRGGMMARTDWNCSKCGVNNFRRRDSCFKCSASREEAEASGTGDGYDEISSVPTNTLLLRNLDVLTTEERVLAVLGQTTNVPIKSLKVARDPVTGVSRGFCYVELHTVSEAAQLDDLLLNLGGQFYIDGRQVLVAYARKPRTTSSGFAAGSVQDSCDVDVDGAEELMPVALRDTLRGVRFADYVEVDTGASVCGALTDEDIIAQVAGAQPVAEEPEAEFCTADDNLATCGAHTVEDIVEEVTCEVADSNDDGEDRRGRRQRTTTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7Y3</accession>
    <name>A0A9D4T7Y3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7Y3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31453" checksum="928967BB20C4D073" modified="2023-05-03" version="1">MEMQSSSAVPNYMRVAGHRVTCDHNGIQRVHRRCGESGHFRMNCTAPFCGRCSTYGHDGKGCSLPCRRCGDPHATVACTIRRLYSEAASKDFPPLQPVTPASDKREVPPTPAPGPAQDQNTQDAMPHPTPSASPVSPDLAGASADNDPVCVSRPLVITIERRAGTSLHSGSTERTDADNSVTSDASHAASSSSANSPTIEESPSTDDGTPVVKVVGGDNVDPAALPLPESSESSISLGVDSSIELSTGLDECDVEMLFPREVKRAHTTGTCSDGAQDSRSESQQPKKPRTSSRGPTCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8Q1</accession>
    <name>A0A9D4T8Q1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HPB52_004296</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
            <tissue evidence="23">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8Q1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025995"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000259">
        <property type="entry name" value="Transferrin receptor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M28" evidence="22">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7982382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21930" checksum="01BC19660BF15DD1" modified="2023-05-03" version="1">MWAAPCVQYILLGAHVDSWDIGQGAADNAASVFIIWRALSALKRLELRPKRTVRFVVWTAREQGMEGATDFFRRYAADSGNTTMAMELDLAAFTPTGLALSNVRSNDTICIVREMLKEFETIDANGLTRGGGAPELRHWREAGVPVAGFNTAWYYHDDMRHSEADTVSGIQSEDLDLSASMVAGLVHMLGQLERKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9C8</accession>
    <name>A0A9D4T9C8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9C8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052153"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7983196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="28640" checksum="ABF3EF68BAF965B1" modified="2023-05-03" version="1">MDAGPAVGRPGGGSSSPTQPSSCGRLHYDGGVLESPRHPFAYPANLDCRYWIHRASPSVCRAQLTFGRFDVGVQRSGRCPSDYLEIQGTRYCGRRDGQTIIVDFPRGRNSIELKLHTDDVYERSGFRIDVKQISSGCVASPLPGEADCDQVITSEVFQLMSPGFRRGGYTGGIHCIYTLRKHDFRVCALEIKMDAFELEQDPGCSKDYLQFGTLRFCGKQAYGATRTIEFLEDEMKIQFHTNPTVSGAGFLLTGKQVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAL0</accession>
    <name>A0A9D4TAL0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_015721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAL0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036640"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23033" checksum="69570CABE3A48746" modified="2023-05-03" version="1">MLYSALDEDSLPSISLRCPKKPRKARTAFTEQQLKTLEKSFERQKYLSVQDRMELAAKLNLTDTQVKTWYQNRRTKWKRQAMVNIELLPGMHGAVSAAGLWPASAAGLSSGFPAAFWPYPYGGYFNAAAAAAAAAAAMGRGGGGFPVSSVGGAAVSGNMESLQRALDFYQQRGAQALLGADSQLRPAVATNINNSASIALGSSKADAELRNEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB41</accession>
    <name>A0A9D4TB41_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048694"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="380"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7984175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="475" mass="55611" checksum="9157C8EF5E4ACA2F" modified="2023-05-03" version="1">MAWRSSKKNAKIVGILRPVRQADDRRTEYLWRALRTAFDEIQDKKSTSQSFNELYAHAYAMVTRNEGERLYRGLCKAVTQHLTNKVLPVVLAKVEDDFLQTLNKAWDDHQISMTLINDIVKCMDRVYAPQSNADSVQKMGALLFRDKVARYADVRDHLRETMLGLVKTEREGKQVDRLSLKKTCEMLLVLGLNSRSVYEEDFEKPFLAESAQFYALRRQDYIKSKKVFEYVAQVEQHIYEESERAKHCLDESTVVPIVQVVKKELVGKYMKAIVDIEDSGVRHMLKNQMTEDLARLFQRLKYIEGGVEALLDCVSKHMRSLGRFVVIKHEDSVSLIPKVMDLRDRFDDFLQRSFNNEQLVRQRMATDFEFILNFPSFTRKLPMHLSVFVDDMMRQGVRKMTRQEFDDLLDKIIEIFRFMQEKELFKCCYKQHLANRLLFHKSGSHAAERTMVAKLRSESCVHLQDGSHVKGHAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBY7</accession>
    <name>A0A9D4TBY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBY7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047461"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10847" checksum="24227B40E998FC86" modified="2023-05-03" version="1">MGEQEDRLQEAVNIIERYLKTCGLQCAPEKSELLVLGARNPGRPQSYDAPDPQGFLQGIEIPQVDSLRVLELHIHKDGSSSATLSRLQNTVAQLTHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCD5</accession>
    <name>A0A9D4TCD5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001212">
        <property type="protein sequence ID" value="KAH7984875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCD5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10768" checksum="C195FDF64C760DAD" modified="2023-05-03" version="1">MGSDHYPIFTNILGFRTAGRQFCNVTRWDTYREALEESTDVGEVVMLMREAPSTCVPGSPGTCVRTAKNIAATTDLLIEGVAEHAATPTTQRGHDEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCW9</accession>
    <name>A0A9D4TCW9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_025583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000858">
        <property type="protein sequence ID" value="KAH7985533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043930"/>
    <dbReference type="OMA" id="YESKWRE"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7985533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="97" mass="11169" checksum="17D757B17A8D5D5D" modified="2023-05-03" version="1">MEGASFKSLQEELAFYREQAVEYKAKWCEAQLELEEFQASSRDLEAELETQLKQYEASNRELRAMVTRLQADNEGLQVRHIGLRTTAEEPPLSLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDP2</accession>
    <name>A0A9D4TDP2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_025016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000459">
        <property type="protein sequence ID" value="KAH7986379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDP2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045831"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7986379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31957" checksum="8E8DD7D605ED99CE" modified="2023-05-03" version="1">MIAIDAITDSNCPAAKVVIAALYYNPVLLFETLSKIQRPDTQENLLDHFVKMWLGNIEYFMGLHDRKMCVLGLCTLISQRSRPQALSEMAPQVVPSLLVLFDGLKRAYAYRAQEEEESDDEEEDDDDCENDVLDSDEDELDDEGQEYLARLARRAKKGSPFPVTSATIEDDPDDDDDDEDEEDEEEETALESYTTPLDDDECPIDEYQVFKEVMQGLQSADPMWFGALTSGLSAEQQKSLQEVYVLADQRKAAAESRRIEKSGGYVFQNQTVPTSFNFGGAPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPF9</accession>
    <name>A0A9D4YPF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_013112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029097"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000056">
        <property type="entry name" value="Y+L amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7983606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20619" checksum="30B6A6295D516BF1" modified="2023-05-03" version="1">MGEDEGRVKLKKEIGLFSGVMIVVGTIIGSGIFVSPKGVFEHAGSVGASLVIWVLCGLFSMIGAVCYAELGTSIPRSGGDYAYVLEAFGPLTAFLRLWVTVLVVQPATLAVLSLTFATYMVKPLYPDCEPPDLALRLMAIVCLYAIESHGTPKKNVAVISSPLRRCMRERFGHSKVLDSCSFDGEAGMIQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQV4</accession>
    <name>A0A9D4YQV4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_022250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQV4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050885"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7984552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="230" mass="26985" checksum="EF6B0FA437D421DF" modified="2023-05-03" version="1">MWETKQVLLKRWKRPRHNRTLRRRIAKLDKDIEEHAFQVRLAQWEETCNGLETQMRGASTWRLFRHLLDPEETKTAHGHKIRRLVRDFGGTPDEFLEALRKSGRKDPISAEKRHFFRAPRDSSRLQVWQRAIPRLDKQLPSSCVVCDLHFEDSDLVKEFVHNIIGDVVIIPRDNWALKDDAVPRLFPNCPSYLSKPARKRKHPAVRRAPPVKVRKRQGDGDVTSPRDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBU9</accession>
    <name>A0A9D4PBU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031585"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="159"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="367"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="531" mass="59841" checksum="F424F14A5CB84D56" modified="2023-05-03" version="1">MAIVFIEAWVDILLENVPPTGNAQPLNFQPPNGNRRRQKVAPAYRPALGDSSRTASELKKKRKCTVRAHKSQVSGIPPRWDRIRIPPLQRNAYTEHVITAQRSELEVNAYRLGNGIVVSGRDAPKPVFSLEEANLPDCLREWLEMKNSLTVTSIQAQCWPVAFKGRDLLAVVQDGTEAKAAAYLVPAMAHLFSQPPFKCANGPVALFLVPNREVAREVHKLACEIQEYTKVGVACICCRDPRQPQLEQLEERPQVCIATPGRLLAFLKEGRLNLRRCTCVVFDGLDYMVDVGLEDEVRAIVDWMPPGRQTQIWLNSRTRNMRLLCEDLLDDYVQVSIGVKMVLSDQNVEQIAIVCDEAEKNDRLLSVLQDILNESSSKVIVFVETKRTVDDVATLLLLREWPVIGVHGKKKDDKLDWAFTTFRDNWASVLVCTDVCARKLDAAADVRYVINYDYPGSSEVYKRRLEHVSGSGRTAVAYTLFTPKDKRYAGHFMSILLEAKQVVPPELRDMAKGTVRNRKLGVGRTGERRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC06</accession>
    <name>A0A9D4PC06_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC06"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047916"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7936080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25640" checksum="18BE4F0B55AEB6DE" modified="2023-05-03" version="1">MASVLTPETTLLVMLFWGILVRPRTDSRRPVAVAVPDEEPLLLSCSGCSEDENNTLTFVQKLKLMKPLLRFMIPLGFVYFAEYFINQGLLELIVFRNITLTHKEQYRWLQVMYQVGVLISRSSVNVVQIRKLWLLPILQFANVAFIFSEAYFLFLPSFWIVVVIVLYEGLLGGAAYVNTFYRISKDVAPQHREFSLRIASLADSTGIAVAGAVALPVHDAMCLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC26</accession>
    <name>A0A9D4PC26_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_005731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC26"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045053"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038475398" description="Vitellogenin domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="16"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7935306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="564" mass="64376" checksum="692DF7F43E141630" modified="2023-05-03" version="1">MRVLWLLLLAAVTSAFEVGKEYVYEYKGTMYVLNPEQRHQLTGLGFRSKVIMQPKPDHTHFKILNFETETFNSEEIHLSHHEFHYTPNDLLHDAIEHPFAGKFDEGKIEEIAIGKDEPLWSKNVKKGILSLFQLDLVKGRHEPHSEKKYHVREDGLHGACDTLYVVHEEDHDYIELTKIKNLEKCDHPAYAIIGREVAKKCVKCEAQETHPASSTSEVYYELKGTAQHYVITHAWAESGYLFKPHGEGKKIHVKLNRTLHLQEEHDAVTDTALGEHLEKEHSLAQEFATTGDLTDVGELKFPNAMYKHYAVHANKEKVRRSSIMRKYTDDDIKEIDNKPRGSETFLTLYNSFASFDYDEISWVYETQVQAAPEENKESILHAFLDLLAAAGMNPHITFGLNLIKNNQISKMDAHRFYGKLHLNLKEVSTALIYEIADSCKSEAVKSHPGTWSACKFAASTIASGKGCKHAHDDHEEDHGTCRPEIISHIFNARAIALPVFYNTSEPSEIRIASFLIILFSHPEMYLLRHIALEMLTEPSDQVVSFVSSAFRTLAKSKYPCHRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCA8</accession>
    <name>A0A9D4PCA8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCA8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036409"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF426">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="386" mass="42210" checksum="8DDD30423F64367D" modified="2023-05-03" version="1">MALIALPASQINATSYDERTYGDIANQAEAVHGALESLGVCAGDRLCLMVDNLLELLPMLVGAACANVGVVYETPGYAVEVLIEWMKNIDFTAICCELSNVDSALELKARLPTIKHVIVLGEGKNLPSGTEAAVILWSQLIKMGTKARRLSALSVEYQANRICYVAPTSGTVGKPRMVVHCHDSLVASVQSISHQQHMGLTVEDVFLCTSPLGHGYALFDCVCKAIVQGATCAFLEKADTDALLEAIQRLKASPYLPRCLLEHPQRSHYDLIHLRYLATATTYISEDVARRLFRELNLKSYVQIYGKTEIVFISGGLHDSPPRFTSVGRLGVGLEAMVIDTETKKPLGPMQHGELVIRGPGLMRGYLGMEDEPYTDPEGWYRTGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCC5</accession>
    <name>A0A9D4PCC5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_002455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCC5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028072"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF89">
        <property type="entry name" value="FI03229P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter family G" evidence="8">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="162"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7934963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52698" checksum="532365836330FF95" modified="2023-05-03" version="1">MFQAIHYNRNFSFLNPDVVLLDQPISGMDILDSFFLIDYLRQWAARGRIVVMTIHPPTYEIFTMMTRVAIISTGRMVYHGKRRDLLPYFSYIDFPCPAFKNPSDYYLDLVTLDNLSPEAMLESSQRVENLVEVFRRRQVALSDPGPPGNAPMDVYRAGFFGQMLALWIRALIYTFPYNVVYFFRRLFLAAFISVLLGAIFWNVRAGLDQEHVLDRLGFHYTLLGLCLWPLLLGDITDVWREKTYVSRDINERLYNGIAYIISKLTYSLPTATAIAAAYVFPAYSMTGLPQREETRNFGPYMGYTLLYLLTVRAIAMTSAWTFPTRQRAAAFLGLVVLVFCLSGGYAVHLMDLSLVTSWLQWVSPLRWTLEQLAMVEFAGGTTPMYDCPRGPVVLQENGIQVKAICGIVTDNHALALFGLHREWPTAQPILIVLAVHAVFIIASIIYIALKMRGPGATPDVDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCE3</accession>
    <name>A0A9D4PCE3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCE3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7934829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20546" checksum="68DC26AA83130D4E" modified="2023-05-03" version="1">MITPKRKTERVPVPSERQRADFRRRRPAETNRGLSTTLARFRRRPRCPRTRTAWKTRRVEEQAAATEVDAPSTVEDREEPSKSDAAWCPKRPRLRSISVVARASKRSTGSTPLAATLMQVRRWSRAAVVALGSGTRPMKTRGVRMVKVSAVPCPVRLQMPRQSGPPVWYDRGVAAESMAVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDL2</accession>
    <name>A0A9D4PDL2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_012267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDL2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025914"/>
    <dbReference type="OMA" id="VMHTMWL"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7935683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="279" mass="31980" checksum="AF1F0F57976C6756" modified="2023-05-03" version="1">MAAAEMNFRAHYYDKVGFRGINENKSLEILLSEKPIDLKKLSNFCRKFCLPSVHRLTVWKVLLGILPTFEENITSFEKDEEDQYNDLRRALEVMRVVKNGTPQADTIVLLYLVGEGKLHLDIELQMSDDEVQHIRSIASVFTKICSRPEEAYWLTRNFWKHLKKLSIDSDAMGKQVEDTLEKEDHELFQQLLKIKAFPVLPLETWFQRCFAEVLDEDALVRLWDKVIGGSTRVLPDVAALLLMSLRVALLSATVTADVLTLLSKISKETSEAVVNRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PED6</accession>
    <name>A0A9D4PED6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PED6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051659"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="83" mass="8693" checksum="67E5EA01F2003D06" modified="2023-05-03" version="1">MMLVKGSHRFNVEASGGGRNHRNFNVGGSVHGEYDLYRSRGGTRVVASGGVAHGATRIDGKTYKGRPQGSVGIGVEIPIGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFR9</accession>
    <name>A0A9D4PFR9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036236"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="22196" checksum="90A924522EBAF5CB" modified="2023-05-03" version="1">MSQRNFLDVPEDGDASYESLFRQADEEFRQFVKTLSNEPGAPKLKSKSIKPSPGFCVKTKDSSNGNKLFINICHTPELPEPQDISDEELMHILGSDDPTTYRVPLSLGLPHEEVDKSGSPCTAYDVIINEAFFRKISSNELFKTFLITVALDGIEEKYKAHPERESYVVLKNKLYMGTMPDHSIQDRKGPLISELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGQ6</accession>
    <name>A0A9D4PGQ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGQ6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21061" checksum="56585DF515942543" modified="2023-05-03" version="1">MFPVTGYRTCKKRPKPLRRKRSKTFNTSTSHSPRGHGSKMTKKQLRWLSSEAEDQDVDWPGLPPASDSPLSKDHSKSRPCSSLLQSPQGQGFRTPQFGSSRGGKDVASPSAPITNNPEYQRTAAENKLIRENLAEMKKKLAFLKAHQKQTPQKQISHPVPTRLGSSVSVNTSPDLTVTLNSPDATWTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHS1</accession>
    <name>A0A9D4PHS1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_002723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHS1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041191"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7942948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14434" checksum="1C8AF4B32BA97317" modified="2023-05-03" version="1">MAAITRLCRLSLKLEKMWAVAPPQARFLSSVVKHRAPCQPLSAASQPALQAQLLYQVQASTQFLPLRSYSDKPPLTLDSIRDRTMLVLKLYDKIDPEKLTLESHFIYDLGLDSLDCVEVIMAIEDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHW9</accession>
    <name>A0A9D4PHW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049766"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="352" mass="39438" checksum="0D364B645A5D1D24" modified="2023-05-03" version="1">MTADGGKAHSCNYHDGVGHGVRNSIERWKHFDDQVRANAKPRGPGPETAGYKRWCRRHRPFHWLRCYDPEAGRCHYRLGHKGDHQRDGLEHLESEPAKARRQVARSLGTVVGRQHGGQSHIAEPSFPAEAMLIPRRPKRGSLTVGVAALRSQWIGGVRTGGTGSDMFQVCSSSRYAGVKAERKLSLFSVPKDESRRKILERNLHRSDKALEENCAVCELHFEDRYILREYVHIIDGKEVRIARGVPALTPDAVPTVLPNVPKYLSTKLPPKRAPRKREAPTVPGPQNSKKACTSTPVDEDFESQGDVHDVSTASLKLENLRERPIQFARSAPYSVNECRLSKSAPFVPLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PID2</accession>
    <name>A0A9D4PID2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PID2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031250"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="358" mass="41182" checksum="730DB3E82E300A75" modified="2023-05-03" version="1">MPLYPSFHRTIRHANQTDISLKWRCPGRRATVVYRRGRALYLNATRLSEYYGAGLAAHALKNISDGLLARRRGGLMNVLVLGIDSTSRMNFNRHMKRTRRLLLGKLNAFELFGYNKVGDSSFSNQIPLLMGKSADEVKRIVRNDNLDDLLLLWNHYSVRGYATLFLEEMPFYSLFTYPNYRGFRKPPTDYYPVPVLHAMEENGGIDVYCAGSRLKTQVFLEYLKDVMDLNADHGIPMFSYVWLSDVLHSNEHGLLALDDPVHELLRDMQKRRALEDTALVLLSDYGARFGSNRATVIDRLEDNAPIGYVVLPRRFLRGHPKAAVNLERFFLVGVNTDSCFWPFTRAAWRSLIAREQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJA4</accession>
    <name>A0A9D4PJA4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJA4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18661" checksum="C2E51DA5B81ED989" modified="2023-05-03" version="1">MAVRPRDEQPSEEDPDKRGGGPSDNRANSKTKGPNELRKTQSAVQRVAAASWLPRLPKDQIKVIMRPRGGLDVARVKLMLLPRAINMAAALTEQQVEDGTMCGNKLNTAAYAKVQKCHTNVGAHEVAASVAAPNNTSKGVKNVDPSLDEATLHRLRVHARNPTATKEANQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKQ6</accession>
    <name>A0A9D4PKQ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKQ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035370"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="11848" checksum="D95FFF6920E80D83" modified="2023-05-03" version="1">MLVTYDANKGYSIDLLGAVHLLCHSWKELAPAKIANCFAHAGFSRSHAEDADDDCEDCDDLYEAVNSITGGDLEGNFESFAMADTDVPVVAPATDAEIVDLLGGPDEENEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM37</accession>
    <name>A0A9D4PM37_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM37"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036105"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30438" checksum="6AABE46CE03F77F0" modified="2023-05-03" version="1">MLESITFKIGNALRMFRRIMNRHRGLGEDNAIRMVHAFVLCHITYVAAMLNWKKSGTAKARSAHTTRFQDSLGVHNPLTEIIEAQHTAQIARLSSTKAGRDILVKLGLNTIVERDNVQQLPKTIFESVTVLPFPRNVHPIHNHGRRLARARALAADAARFPDQTAFVDAAHIPGKHAYSVVVIDGHGRTRNSLTLYTKRPEVAEQAAIALALTDSSFTTVYSDSRAATRAFAKGGINKTTLRILGGHKITDHSIVWFPAHMGSLGGGLRNLSSTASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM73</accession>
    <name>A0A9D4PM73_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM73"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="378" mass="41482" checksum="D3063442555BBE8F" modified="2023-05-03" version="1">MPDLPEDHRRIVIRPRDGLDLRKAGHCKVAEAVMAAVKITYDAAGEDVVCPNVTQNIVVISTPLEEHANYVRIKQIKVGEKVYTVNAYYSAGDGYCKGVIRNVDREITEKELNTMIVHSGNPTAMQAKRIKDTGSVVIVFEGYEVPNHVKVGGVLLKCYLYRRQVDVCYICAKVGHRANVCPTPEKKTCRGCGVENPTDSHECKAKCKLCGKGHPTGDRTCKQRYQTLFIQTTWAQKAGCVKTQQVSGGSPTWQPGSEELKQMREENSLLKEMVMTPKEEIGTLRKALEATSKSAPVAMETSAGPVGRKRKAVGDVAVSDKDGFESFRETMEKSPSEITNILQQLRVDVREFKSIALITSMAGADGNAKFGSENGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PME5</accession>
    <name>A0A9D4PME5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PME5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048320"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7944286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77859" checksum="3D500AD0F2223A24" modified="2023-05-03" version="1">MIHRKNPMENIPRESEQQLSLSAFEERADTSAIADRAEVDRYRPPCTAVSDQVCQLNNCLSYCNNLLFDSGLQLREQRGGSLSLVSIRVNLMPRPDPDSYRATAFLRWLLKTHVCITTLELSDDSVNHLETHFPRLRNLEVLNCSAGRSHFDGVACWRTDVVAAVSALLRTTKCLTSLALHGCFGSRQPPKTLIDALSANSTLKLLDVETEWETAEPPGPLGEYVRSNGFVTSLTVSGRDADRRNLLLEETLVLNRTLSTLLVLNLCGGENSVRFFTRILEQCCNLRKLDVGMSRAQYTHISEATLTRCAEALAQHQTLEELTLSYCLWHPNNWIAFFASLSRNKRLKKLDVHHQCTQDYPTLPPVLEALAQTNSSIRVSFGFYVPGVGVNLMDYNVFSRIGLSGDESVQVDALQRLPFLDHFTSLSLDVYGAGERLFSALAKYIRETTALRELSLSVTDPFNTANNTATSSCWTLLFESLSANKSIAQVDIFSNGNFQYNDHLTRTIGHSRYISRVSFLDNSAFGDATDFVSLLSEAIGDNYNLLKVNLCGAKLGVEAKRCFFTIQETTRRNCGLVERAAAFNGTTPLDWYTASAFEKVARNPALVRELAEKEGIAASEVARMIRSRLTSVEGLHDFMRLTGVVKECVMCAPPVDGCRMQLQDLNNDCWRLVRRYLSFDDVRRFGIANEDHCTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNQ9</accession>
    <name>A0A9D4PNQ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNQ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057835"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="132"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="370"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="691" mass="77854" checksum="9E6AE7D7C7498593" modified="2023-05-03" version="1">MCEIRDEFYVRIRQVDMLRYDSQHYSRKQAQALDIAIRCALSQDRDCLGRLLLRKAPKEPAPQKQLTTPQYRAPAVRGRYNPQRGDPPAKADDAEKPGEAAYSGILTSVRSGQYEMFLNADTILTSFYEDGPLLNYVEALLGRQLGEHPQLEEAEIKDLNTRLHGFKVCVKHLRYTRSRKIKQITKKGADEIAVTEAQTVAKYFEETYKKLDHPSLPCVEVESKKGKCYYPLEMCFIPLGQRGEQSQSGKPLTPSERFARAKGVARELAVRREDILGEFFTSISTSPVECRAKVFPKVNVDDLKSPMGVVPWTILNVNKFNTVSDVAKLKKNLIAQGIRQGIILDVKAKIANRNNPDLVDILEELKAVEFLVIILDSKKSVYYNKLKNDAETKLGLITQCVAVDKSKYSDGSIGGNLIRKIKAKLGFVDKAMPRTIDGFNCEDALVMGADVSHHGPNDQSPSVAAVVASIDGRASRYVAVIRPQAKTDGNTREETISNIESMAKELFHHYKKKNLRKIPKDILFYRDGVSEGEIAEVCEKEHKYLQSAFAEVFGCNPRITFVTVQKRHRTRFCRKNETNVPPGTVVDRTITQHAKRGFFMCSHTPIRGTARPAHYRVIYDDNGFEPETLQKITFSLCHMYARCVPAVSIPAPVYYAHLAAARASCYMKATEQVDTNPINVVGNCRDKMFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNV2</accession>
    <name>A0A9D4PNV2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNV2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9203" checksum="E599B92E77367F2A" modified="2023-05-03" version="1">MSVFLRVDVLAVTPETEPGANGWSFGSSRHSSSDRHSSLVAAVLRRVMPRPEIKLDAILVGLWQWPVAWIHGAWIQSTAGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNZ7</accession>
    <name>A0A9D4PNZ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNZ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055510"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF78">
        <property type="entry name" value="OS12G0587133 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="401" mass="45359" checksum="DB958FE22F914D37" modified="2023-05-03" version="1">MTKSKALPFGAFPRGALGNLEGVDAVKVLAIYFCCGGVAETTWQRVLERVQAAITRLSLENLTLREKALAAKTTICAFGYYASRIAVMPTKTATQLSKMIWSFLWEGIPAPVRRTLLQLPESEGGLGLSHVLTTSKVFALKTARALYHASDYVGRGLMRNWCSTNAAFLKADRPLAPLAESPSSFYKSAANTMRMLEKEAPDCDVDEVPPARIAEEIARHQITPDEKRLSRNWKRKASKDCRGIPRSVHGFVWRKNWDVLPTRQRLHKIGIVPSPRCSNCRADETLAHALFECPAAKPVWRLVARDFKIRPPPELKRNRGAFAKLVVVCTIFTIWKRRCLAKARRKPVRAAFPAVSRVRGMLWQHLSEQLESSGEEKFLRRWHTRFFLLQEGKLRLPITPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPY2</accession>
    <name>A0A9D4PPY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPY2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10745" checksum="CDD814EFF00CDEEF" modified="2023-05-03" version="1">MRLWILDRPDVTTVEKAAELAEEYASRHASQQSEGRTLDAFPKQGAENGSPKLFRRNGNAKGPDPEKEIEQTLPKATFKDEKNKQFEAQKADNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ26</accession>
    <name>A0A9D4PQ26_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ26"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027640"/>
    <dbReference type="OMA" id="GIHKWIA"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12294">
        <property type="entry name" value="RRM_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12951">
        <property type="entry name" value="RRP7_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034890">
        <property type="entry name" value="Rrp7A_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="2">
        <location>
            <begin position="148"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="267" mass="30440" checksum="59F4E82198E834FF" modified="2023-05-03" version="1">MAAPSKDAFVKMPVKFSGESRSSHVMLFKEHSVREKSEHKPSGRTLFVVNVPPYCDEDSLKRVFGDCGKVAKVWLQKSPSSGKPAENTSSFFPSVAPVTGFKVAYVVFHKEASVRRALALSLSEPRVLFHEDCNDVIGVAKWCAQYKSTFVDAEKVQKEVDTYMADYDARLEEEKQRAKAMDGVPDEDGWITVTKYGKRPVIPRTDAVSQKISSAEKKKRSQKELVNFYSFQIRESKMERIAQLRKKFEEDKRKISLMKASRRFRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQX9</accession>
    <name>A0A9D4PQX9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair nuclease/redox regulator APEX1</fullName>
            <shortName evidence="14">APEN</shortName>
            <shortName evidence="14">REF-1</shortName>
            <ecNumber evidence="14">3.1.11.2</ecNumber>
            <ecNumber evidence="14">3.1.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">APEX nuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Apurinic-apyrimidinic endonuclease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Redox factor-1</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="14">DNA repair nuclease/redox regulator APEX1, mitochondrial</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_006992</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12 14">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="14"/>
    <dbReference type="EC" id="3.1.21.-" evidence="14"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQX9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043478"/>
    <dbReference type="OMA" id="YEVAHVG"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000009">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="16">
        <location>
            <begin position="62"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="13">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7951243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="312" mass="35012" checksum="CA6160E03787B7A6" modified="2023-05-03" version="1">MGKSDAKKTSKRKRGGDGEATEPEHSAAANNAHETSKKPKSEAGEQAGSGDVAKKPWNLKLCSWNVNGVRAWLGKEGLEYLKKEQPDVFAIQETKCSDSKLPTEIKNVDGYHSYFLAGDQEGYSGVGLLSKIKPLDVKYGIGVEKHDKEGRVITAEFEKFYLVAVYVPNAGKKLVRLDYRMEWDKDFRAYLKELETKKPVVLCGDMNVAHQEIDLANPKTNKKNAGFTQEERDGFTTLLDTGFVDSFRHLYPDKKGAYTFWTYMMNARAKNVGWRLDYFILSNALESNISDSLIHSEVMGSDHCPVVLLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR44</accession>
    <name>A0A9D4PR44_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR44"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050841"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="266" mass="29943" checksum="219E0F0945EF28E5" modified="2023-05-03" version="1">MPQYCAAYGCCNTFGRDEIDLHKFPRDQKMAAKWVTGVKRKDFKPTRASVLCSKHFHDSDYVRSPSLMQSLGLTIKNSDAIPSVFPHLRGASPRTLPVGTRFLVPHHRRWQHLRSSFLQWRPARHVTATTRRFQQKKRKTRHRLLEYAVSCLHNSVDDATELRPITGGGETRNAGRGACCSIRRVAEFATCPAMPRGSTVSTMLRSGSVTHTSVLGVFSIWYFGVLSMHDRACLSASCVLTAIEMFNHCSNGGPRATEFKDYQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR45</accession>
    <name>A0A9D4PR45_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_019999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027752"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029278"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7948267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="451" mass="50661" checksum="160DF165CF7BD940" modified="2023-05-03" version="1">MTIKKPNLPADDIKIIVRPTDGFCTATHRAARIGDSIRNAAGLTQEETRGDIFRVNERQNIIVVSTPSEERARRYCEICKLRMGDKEYEASAYAAAPENTTKGIIRGIPDEDSPDDIERHLVNEHNPTLLHAKRMGKTANAIVVFEGSVVPHYIYYNGTEHRCVLYKKQYETCYACGRLGHRSDVCPNPQSKRCRGCGCDDPAEDHQCEPRCRLCGKDHPTGDRKCHAKYRTPYIVKKRLWERRQREEEEETAKDQRHNEEGGNDFSVSWAQKAASGAHARFGTAAPNSEGENDIIMQIQKRLEQLESDNTRYINVIKELREENAKLKDEQLVQQWPNEGSWRLPARCGAQPVMGELRTDSGDKLRQATTVLAVTVETCGRVGGYAEHQARKAEQCSAGIPVFSDVAEDRPGHPPRSEAAIPTTTVVVHQPRGVTPMRHGDTSDHLDDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRA1</accession>
    <name>A0A9D4PRA1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRA1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="12747" checksum="5879A80561C645E8" modified="2023-05-03" version="1">MGLKTTERPPTPGFLDCSPKTLADVLEPSPALRDRSGLPQFFMIQGSGAGDIAGIAGTRSVSAAVPDTRSHPTDNAGNCGDRSWDGRPWGTTGARPSPRLASPTAERHLASLLQQLRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSM4</accession>
    <name>A0A9D4PSM4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSM4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026645"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039160596" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="23524" checksum="127A9EAB3EEEFEDC" modified="2023-05-03" version="1">MRVLTTVFVTLFLLIGEVICSDGDGSAGHDAQCKPDAADRCFSVLGKCEVKGGSSQCSCPEAFNWDDQEKACFLEVTEMNLCDTYLKDVAPKFGKQYECTKRNNESSYALTCKKSHRGMAMYTQGALQVDICAERKCEEYCTETERQCLEGKCVCHLNYIESSEGVCTHYTPNVDRVPNILNVIARTGAADCTVLVPSSGTQGARRLRFNCGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTY8</accession>
    <name>A0A9D4PTY8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_011263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTY8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030556"/>
    <dbReference type="OrthoDB" id="6515806at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038670128" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7951695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14008" checksum="83E4458138048A8F" modified="2023-05-03" version="1">MQAKVMAPVFVAFVVAVAAISAVAPQERLDCPAVDDKGDNATYLPNLYNCSQFYVCAQGVPMLMECKGGLHFNRKLNVCDRPWNALCVALSLPGSELPTTVVPVPTEKVVITKTVKEVYRPVDDEAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU45</accession>
    <name>A0A9D4PU45_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_003740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU45"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7955756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32788" checksum="181877D8AAD65151" modified="2023-05-03" version="1">MSRNRKPLTLGEKLRIIEEAEKRNGATKASIARDLNIPESSLKTILAKKDSILLNAAKFGLNRKAAKDGKYAAMEKALVEWLRQARSSGIAVDGAILKEKAETRRLAGMERKQLDKKLSVLDAMHYIASAWDAVTPETIANSFRHCGFNRSGACSTSEAALPVDDEPEFGSLELPGSFADYVGANDDVAVCSEVSLDDIIETVRPDTAGTSDEEEMDDAAEASVSVPTYADVLCYVDHIRRRVSSEPPKRKVVSVPLHDFPHPLSCAIHALTTVECGRFNGVLLTSTASLLMRAMTNAVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUK0</accession>
    <name>A0A9D4PUK0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PROCN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUK0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044178"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROCN" evidence="1">
        <location>
            <begin position="277"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="376" mass="44574" checksum="524A7AC90802D6F1" modified="2023-05-03" version="1">MNGVTYRHWNLTLPQMATLYRLANQLLTDLVDDNYFYLFDLKSFFTAKALNMSIPGGPKFEPLIKDMNPADEDWNEFNDINKIIIRQPIRTEYRIAFPYLYNNMPHYVHLSWYHTPNVVYIKTEDPDLPAFYFDPLINPIAHRQGTKQTVDPLPDDEEEFELPEHVQPFLQDCPLYTDNTANGIALLWAPRPFNLRSDRTRRAIDIPLVKSWYREHCPPGMPVKVRVSYQKLLKYFVLNALKHRPPKPQKKRYLFRSFKSTKFFQTTTIDWVEAGLQERKKSRFGNAFHLCREILRLTKLVVDSHVQYRLNNVDAFQLADGLQYVFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLVYYRFNTVSPVLSCHAFLTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUP7</accession>
    <name>A0A9D4PUP7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUP7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12049" checksum="FE1B6527A77E7597" modified="2023-05-03" version="1">MLGSLGVVVVSIWNARCVVPEIPCSSFYSRKDPQSLDDILNRADAGEDVPSVVAILPPDNGAAAVTDDESGDEEATSMDHLLGSTLLAEVVDSCSEPSDDEEEPPAKLQERHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX07</accession>
    <name>A0A9D4PX07_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX07"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040516"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="80" mass="8854" checksum="AFFED34EC0946B75" modified="2023-05-03" version="1">MELGKLVRICGQLGRRHVSSSRVHEHRGPYATLSDVDVATFERLLGPSAVLTEPADMEAFNVDWLRTCQGECIPLTDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXC8</accession>
    <name>A0A9D4PXC8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXC8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="9993" checksum="D860D9B5498FF269" modified="2023-05-03" version="1">MVSEVPGLNASSSHGRTTPAGHLVFSGNSVENWHERSRDVADLTLQELGDRVSRLEADATCLVCVDRRRNTVFRMTGLALLCCPGGQSRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYL8</accession>
    <name>A0A9D4PYL8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043560"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="502" mass="54515" checksum="8452E4F5B9117323" modified="2023-05-03" version="1">MSGDIDALACALCGRGAAPQNPVGLLIALVNLIVHVPFTDLPVLRDYELGELRQQYDYVIVGGGSAGCVVANRMSANPDTTVLLLEAGGLETASRQIPLTAAYSLGGHDDWDYRTVPQRNSCLSFHEQWCPLSRGKVLGGSSVLNFMMYVRGNRHDYDRWALTYGATGWTYEDVLPHFKDIEDFRAEPVDEYHGESGEVPVGYPNASTPLNELFLNACKESGYSIVDYNGATQSGCSRLQANVANGERVSASKSFIQPVLKKRNNLDVALFSQVTKINFEGSRAVGVTFTRYGTSQNVSAAREVVLSAGTVGSAQLLLLSGVGPREDLERLQIPVVADLPVGRSVQDHAFLLAAVPVITDWQVGVSLFTLQDIAQYDTTRSGVISIPTAIEAVQFIGTQYALGLDSPDVEVAIVSSQPATQLARVEMLNLGMLPEAYDTFFGPRNNVPGFRVVVFHTQPKSRGRIALRSSDPTDYPEIDLRMLEHPDDAKAAAEGMRLARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYQ6</accession>
    <name>A0A9D4PYQ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYQ6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10911" checksum="FE072F88082CA381" modified="2023-05-03" version="1">MAQHTHVRGPRVPDNQRELLLSFMEQHPDLAVRASELTHEFTAEDRRRLWDELSDALNSEGPVTKSAEQWQDWWRKQVHDARRDAAAVAEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q027</accession>
    <name>A0A9D4Q027_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q027"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="17698" checksum="4B6A57A8B9F220FF" modified="2023-05-03" version="1">MRIVESADSLTACTRDYLEALKVQYDRLLRASSDRRRVPQVASGEPQDVDLRDVRGNGSFRITELKRPDGSLTEDPAEIESILHHNFKSAFHETNPDTAHSALTLTKELCKHLHHLEEDECLTLCEAASLTELKTAVTSMPPNSAPGADGLTAGFYGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0K5</accession>
    <name>A0A9D4Q0K5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0K5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050411"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23714" checksum="CCBABF0B31206980" modified="2023-05-03" version="1">MTVTRRNGHAAHPDPAHGPGVVLEAGRMEAFLRADPGPDPRVVVGSNRGADLARGAGLGTCKERSISRVNPNRRCKVALGLIGCAAAEDPAERRCAENAFGILVTRWRILERTMGESPENAEWNVKALCVLHNFLMDAHTGSEDSYCGRGYADSLNSLGQRRGGQWRQQLVQTPLQLARTKAHNFANMARYVRDLYSEYFSSAVGCVPWQDAVLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0S6</accession>
    <name>A0A9D4Q0S6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0S6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14826" checksum="7087F752AA773D41" modified="2023-05-03" version="1">MSGDVHRENPILTVRVIRSFEHRNIWHVIMRDVSSAITTGEFKKSVLSSLENNTSIPSAVRRYPYDTLKIEHVPHKAKSNDPVINTDDDDKLILLDHVPLSEGGVVHETVLSLFKMDDYLQYKSSKLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q156</accession>
    <name>A0A9D4Q156_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q156"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="14090" checksum="532CF0D15E3D057F" modified="2023-05-03" version="1">MKRQTISDVESCLAKAKAENANSEEFAITKYGEVLQWYRASRNKYPPPHRDLTRKEATTFRHHILWECWPPAPNTQDIEMPDKIGNKITSTDLETQRAVVQHVLELLDRQKPETSSRSRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q179</accession>
    <name>A0A9D4Q179_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q179"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="799" mass="87032" checksum="039AD4C49BA32857" modified="2023-05-03" version="1">MDKAKDNFKLGSSPDLTPMVDGADVHTAQSRSHSVLLITIATLALLAAFIATALLIFPKQLQRTYQAEKEPALQCGDEMVPIISLVNATGDPCTDLYRYVCSNAEEPDSSYLPPAFRTALAWELVRDAVSETRRAGGATERASLLRHEFWNWLRLNEGERVADFVHALVKAGNVSTSMTASQIRHLLTEMSLRYALAPFVSSKGSATRLKLERSPLCLGVGNHTVTLAVRAFNDDLNASVEVDDIFKVDKALKTFGERAGGARSVPQDIDKVPFRHLGQSDWQDVQNDPTLPMQLDKTHLSQTDSQRLDELVRLIVNAAKQPAALAYVITCAAINGVEALQPETAAPSSRLYRTTCEFFGICELDDIVKLESMRSTAADKRIRNMFSEVREEVSSAALNLSSLFGGSNVTTIVEQLNSVTLLLPSDIAGLDVPLPDMSFRLSAATAAYLLTYAGSMCQWPYEYRFYDERGLATHDVHVILGIQQLAVLLGPYLVAWLGSRSPPVLRPKATVTLCLMATALACEIKRTGLCWETCVVVGLGPSVAASWLDIKDHVLVVRHLQDGNDVTLYRTRLPRVQMYATMLAWAATGLLVDVYGWGIEWVYSLASALYATAVLVVLLGVDDGNDMQPLKLQGVATARDARLVPELVLRRVSLLLEDTETLSTHAAQFLLEAVAVLNRAVFEMTGPYPCGRMVSSLALIFLFRQCTEAIAWSFAIVAQLSGASTSVMAACGTSVCMSAFASAYRYTAPLRPEFCAGHAFLSFGTTMATAGDFTPPWHRSALAGEKASLFSAATRARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1M9</accession>
    <name>A0A9D4Q1M9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1M9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038048"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="712" mass="77227" checksum="43E420D4DA2D2881" modified="2023-05-03" version="1">MRVTQRGGAKKWGARERRKVHQRRRLASTGALEHEEGDVGNAPVARSTPPRWLPGQQQRLREACARQGKRASSSERSRADGVVALDSVAGALFFFFSSSLSHRGCVGGKGQTHAVSDFPVIDRLGQQEALTRGNLSAELRGIATMLCYDHHRDDDSSMVALSSLGPPRSSTDPGRYTDTTHHHLLDVPRELRGLSREIASDTHAAAPSLASLRRASQARPVPPHSPTTMEETVDEETTNQQDCHSGEWQTVLRAYRNRAPGPNSAPKPLSTASVPAQPSASNASAPPDAASASLRTAFEAEPELLRTTRAVVQKSKQLAALPAGTIRVVFRPRGGLFLEQHPAASLLQALHTAVDGSMPGELHIRVHPTNNTFTVATAEEATALALVKVQEIALYGKQYPVAAYIAAPPAAVRGVISRAYWNETPEQILNDLRYRNPDVNIIAARRMGKTASILITFASGPVPHTIKYMCVVHRCTKYKGSPDACTNCRKPGHRYDVCPLPKSGLCPRCGEKHDKKEVPCTPTCILCGGNHLTGTGPCKARTPQPRRQTPPKPKPPVPTAKDFPPLAPHQGHQRAWTKATSAPKASLREEEVALLREEHPCDPSNFIDPTLHPSTPPQKKRRPDDTPDMDIDPKFKAFAERLEANIMAQTQKYIETAIATLTERIISQVTTAILQQLPQIIAGVSSHGPAGTPTAAPILRPPTLQYGAADSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2B9</accession>
    <name>A0A9D4Q2B9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2B9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="22543" checksum="393E40274EEBA393" modified="2023-05-03" version="1">MLPSRWRTKAIKLYDKLYEISTYEAAPHNTCKGVIRGIPIEDSLAEVERRIINSKNPLSLEAKRIKDTSTVIVAFEGVRVPSFVKYGPTLHIPAERALPVREALNFRTQRQRDEPGAVPGYPPPRRQTDDHRNNMGRPPQFNRPKQVDGHIPTTTDQYEADEEIESERPTKRRALNGEQESTGGRACSLRDPSDAECAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2Y7</accession>
    <name>A0A9D4Q2Y7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_022336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2Y7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037757"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="24196" checksum="B4CB3238601200DC" modified="2023-05-03" version="1">MSARATQLHVATHAESLNVDAISILPPFYFRSPSIDHLIRYVEEVSKAAPSTPIIYYHIPAFTCVNVRMTEFLPAAKRRVPALCGAKYSCGELSDLAGFLREDKADIKIFFGFEEMLLAALALGVTAAIGGTFTYQGHLAKKIIDLYEKGDMHNARRHQDKLKHGIDTLCKYGFSVAALKAAANKVSGLNFGDTRIPVCPLPDDKAEKLAEEIRALDILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q557</accession>
    <name>A0A9D4Q557_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome inhibitor PI31 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q557"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033945"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="291" mass="31902" checksum="E29681AA924B4766" modified="2023-05-03" version="1">MPNPDENSHSVSCADKYFGLELLFKSCKDTLKSKSDALVLLIHYLLARSGKRCHGTGEKWTQGSHGTELLPDGWNDNQSLYTLRYASIQGSDRYVLKVIPSGGFLLVNVLNVRKERTASTNLTMNTYTSGEFKELSRTYKNLDELMSKLNAEVVSALESIGSATQASSSREASRMVSQENNPLHIPSRQPGIEWSPLQEVPRVGQRDLNPFYQGPPGGGMLMDPRQLPRPHHSDPGVGIPGIPRGSIPPGARFDPFGPPRPDMPPGAPGSRFAGPNPDHLPPPPDYDDMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q583</accession>
    <name>A0A9D4Q583_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q583"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050159"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24836" checksum="318D938EDF213AC1" modified="2023-05-03" version="1">MPRLTSLEWPEVNGSKAFLERGEYAQQTCSLANVVAKRLLDFLVSHPNYSRLVVHGFSVGGYQFGEVLVKIRKEGGDYSAVVPRFKAQVYDSLVDYQGIPKGFPTALTRNQVLRKVLELMIRLQRLVLYPVSTVHWKASSRAFHDNLLTCPALMINSKRDQVASIEDNLRVANGWRQKGTDVTFCTFDDSKHVQHMGRYPDLYCSEVLRLFRKAQLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5A4</accession>
    <name>A0A9D4Q5A4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5A4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30499" checksum="ADADEFE6F058B605" modified="2023-05-03" version="1">MVRDQNLILAYTPHPLIADKLIGELIVPSSVGPVPLFGYLCADTQDSCYGVVTVRSSDSKAELLESEEEARKQAPRAHQHRQQLLEEQATSVIGGWLKECEEARKGEPARADDGAADRWKQKKTKQLVLKKRKKGLAQASQSWKTGKTGRRSTEPASTRGVRAQRPVFGTTSASSSSPRKSCYVACCCRGTRTYARGSRYRASFHRQDGERRKIFAGRRRDPGCYRQWRLPCTEWWVTHSPHDPCCCDVATTPDHARLRHRQEASSPPLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7Q5</accession>
    <name>A0A9D4Q7Q5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7Q5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054428"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="345" mass="39135" checksum="1B8C33F0DEF9704E" modified="2023-05-03" version="1">MQNPHGDGLATKITPSKAAQLQAAPRGPASPGPFHTLPKPQQKMKTLNWTKVPDTLVCGGKSIWSDVTKEAQEEHVERKLNFKQVEELFCQKTATTAQPKVPPDKKKKREPALLSLLDGKRSLNVCIFLKQFKSGPEQIVSMIRSCKSKEIGAERLRMLQKILPEPDELSMLRSYTGDRSKLGQAEQFFLMLGDLRLYALYVDGMLQMEEFRPSVDALKPQLDNYIGVCQEILTNRSLKEFLKLILITGNFINSAAKAQLSELSSSFEQIGQLSRRLAEHFCEEEGRFSVEECLHIFNNFCEKVKLAQKENEERRQLEERAEKLKITRMGTDQSKPGTFPCKAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q993</accession>
    <name>A0A9D4Q993_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_024149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the API5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q993"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034516"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054684"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="238"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7970102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="359" mass="39475" checksum="CB725F21BB332F1A" modified="2023-05-03" version="1">MDKVDLLYKKYDVLASAGDKVSEHETDYLDILESVKGTPSEKRLASQFIARFFKSFPHLSEKAIDAQLDLCEDADVAIRKQAIKDLPSFCKDSKEYVPKIADVLAQLLLTEDHTELVVIQHSLVTLVKLDARGTLGGVFSQVVGGEDLVRERAIKFLCTKLPSMGADVLTKEVMQDVTGQEFTSLMQLLSGLKFAKTIPGQQALVDLAAEQADLGKPLGEAAGAGDGTSRAEALAKLVQCIRQALPYFSLKEALLVWLSAMNAKKIPVSGDILKQKAEVFALQMNVKDFKFSDGWLRNFKSRNDLKFKKMCGESGAVDDSVVAEYWDGKLQSLQLSISWPGLATELAARSASESWKSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAV0</accession>
    <name>A0A9D4QAV0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CTCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_003639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056397"/>
    <dbReference type="OMA" id="RRDWCRT"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039665867" description="CTCK domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="7">
        <location>
            <begin position="110"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7971874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24371" checksum="994B753D2A8A7A8C" modified="2023-05-03" version="1">MRIPEGLLLFLASVPFMTSSPAPRQSAAASSPASTHHPRRTRLQQLQHTFGNGSPVERVLRSDGGPGLVLGRAILVGDFRKNHHHRRQHNKKQVGDDAEDQRPRRDWCRTAPLMQRVWERGCHSALLRNRYCYGQCKSFYVPHGYNVAVAGASDSNNGTSLKAVGIGRGGVGAFVSCAACKPVKFRPVRVTFVCPGQKPALRKRTLQRVHRCRCLAADATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBI9</accession>
    <name>A0A9D4QBI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1 feedback regulatory protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP cyclohydrolase I feedback regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GFRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027792"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044549">
        <property type="term" value="F:GTP cyclohydrolase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009890">
        <property type="term" value="P:negative regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1410.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 feedback regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1410.10">
        <property type="entry name" value="GTP cyclohydrolase I feedback regulatory protein GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036717">
        <property type="entry name" value="GFRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009112">
        <property type="entry name" value="GTP_CycHdrlase_I_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16852">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16852:SF2">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06399">
        <property type="entry name" value="GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69761">
        <property type="entry name" value="GTP cyclohydrolase I feedback regulatory protein, GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9557" checksum="D7154BD037FC1224" modified="2023-05-03" version="1">MPYLLISTQIRLENGPTIVGDRNSDPTLMEHLCARKITQPGNDFPEYRTDDPPRTVLNKLELMGYRVVAMSGIGQTCIWTLHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC07</accession>
    <name>A0A9D4QC07_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC07"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041321"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="21019" checksum="4FF32A1F53F5D1EA" modified="2023-05-03" version="1">MPPTGVLSSARLLSVLSWAEIEDLMLSHKERRLLRHHFTVEELQDEMRRSREAELVRYRSQCGLLDIDGMDSTTFKLMFRFQKHDFNDLCSALLVPREITTAQNVRLCGREALCVLLRRQAYPNRWCDLEGIFGRHSSVMSCATSRLMDHILSTFGHLLTDVNNHEWISPASLKEFAGVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCB0</accession>
    <name>A0A9D4QCB0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_021031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCB0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7973073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="38725" checksum="0D2DBDCAE9EC8930" modified="2023-05-03" version="1">MSAEQAAPVDVKLQYSTSVPSDGSAAATEHASTKVRLVEGMPIAGFCEEWAVRAALRYQPRDDDVFVVAYPKSGTTWVHYLTRRLLHRGHESPAESAMQCMLSSIIGYTGSDTSPGAVIKSHLPFGKTPFSEKARYVYVLRNPYDCCVWYYHQRAGLPNSPAVSFDEFLEDFIEGKVPFGDYFDHLAAWFPERSRPNVICVPYEQLKADVRSGILRIADFLGREIGDALHSDDGALEGIIQTTSPDVMRKHFSEAREALLTSPNDKKKAEVAAAFRARGHRAPAAGADNGDKAKLYRLVRKATVGDWKNHFSEAQAERMKSNMESKMLSKMADHREAVVALWNNLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD47</accession>
    <name>A0A9D4QD47_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028276"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="23936" checksum="87E7C36735B71471" modified="2023-05-03" version="1">MADSGGRFMYRVRGFGSHVECRLVEFLRELDAVCVCSWCGFVTKWKTSLYSCGDIACKECSIEIGSGDCPVHGKTVSRVMELQFPYGYNAGNEKVRCANAMRGCQFEDTLSGLDTHLKKRCAFQFIACIRCRRGVPYKDMRTHFSTCKGASRASSSSSDAASLVEDLANARKELDHALALTDIDGERCELRKAVTSASEMFARLQTQLAMVGTSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD76</accession>
    <name>A0A9D4QD76_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD76"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="183" mass="20535" checksum="17BE4E81F180EDDF" modified="2023-05-03" version="1">MNGQQRSADVVLRTVLGLHSRVDAAGHDRRGHLPNWRLQRGALASFRVGPRSRGRPRLVGCSVAHECPPSGLQPSHRKARTSTDRQADVATQQTAYLVISAKEKEAGDAKTERYPQERNLAEKEKKMKNKQEEREEAESQKEDYVKDEDELVDDEVAAKGANVYDEEGDDPKEDEDKKDETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE12</accession>
    <name>A0A9D4QE12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_008628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE12"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7976087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="389" mass="43494" checksum="7A46B9D7A996567D" modified="2023-05-03" version="1">MAFWVYTLAGFSDFLEQRRIAFEEPMPASRVCSGCGRVPSSTVMLPCGHVSCAQCRGEFFGGSRCPFDGRAFTEGQLVRRCVQLSDLECRRVFCLMGGNKCSTFSGKLSELRDHMRHCRSIGRQCAKCHRLVPSALAVDNSKQCSDTARHLVYDVPLQTAVQEIRGMKEDIEGLRQQALDMHDEGHDLANRANGLLERLSRIDRALSVVPEMVVGVNGDGECLQPLRKEEPTLRPYRAASKPGVFIATCVFSGVYAARDSLEEKKERVVLYTDSSTLGVYTFNLGCHFTLSGNEDAEEVDVEFSMFLEEGDWNDHVGRPFSKVTMVIAHPRDEGKDIRVPYDPHGDKSAKKPRPGDSNCGKSMEKKSWKDLELQGFIVKDALYVNVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEQ7</accession>
    <name>A0A9D4QEQ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEQ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026596"/>
    <dbReference type="OMA" id="CNSVHTQ"/>
    <dbReference type="OrthoDB" id="6498121at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7975353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="309" mass="33977" checksum="74FDF6D91AE2CE3D" modified="2023-05-03" version="1">MEPNRGGFARLRTTPRRQPFSQPHFSSISPPQPSSTSAEPLWTTSEVDQLVELISGRASVLLGPIDGTSKRLAWEEVSQRLKRTEEEVRRKWTGIVADLRQGKRSTPFKPYELAALKALGAVERLRPPASQEPPPLQIVPASVRSITTDTFLQQNTPHRSQAPTMTSMVSPVSISQPAAGLTIVALNREVSITPVKPPQPPHTSSRDTSEELQLLRCCNSVHTQTPPEHDEPSAKKARHSSSSHADATSLLQRLVFLEERRVALQQEQLSVDREKVKCVRDLLAVLGKNDRTVPMPNGDLVGAVVSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QER2</accession>
    <name>A0A9D4QER2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QER2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7977042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="70" mass="8008" checksum="5B99F63F51466892" modified="2023-05-03" version="1">MCAKARTIVGYYKRSSTGRARLQEIKKQLSVDPPLELVQDVPMRWNSEFAMLARLLKLKTAVTIDLTKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFU4</accession>
    <name>A0A9D4QFU4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFU4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047443"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7977024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11749" checksum="C17184CED3B88635" modified="2023-05-03" version="1">MHKRQSLRLPVQMPGSSQFADCSASRAQQCETVLLAQQVNDASRATVPELLTRCRYIRQNLNCLLNYTALCLPLEQKEEKSQVIVSARKYAYATCEDRDAVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG34</accession>
    <name>A0A9D4QG34_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_003308</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG34"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000015">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000019">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="17">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="438"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7982148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="484" mass="52988" checksum="574413F227BF73D3" modified="2023-05-03" version="1">MITASHNPEDDNGIKLIDPMGEMMETDWEILATELANAPDSSLESVLDRIVAATNINLQEPSNVCLANDTRASSPGLAQAVSDGVKCVGGVVKAFGHLTTPQLHYIVRCSNDPSYGEPTEEGYFKKLTKAFMQIRANGSAVRNYVPFIRLDGANGVGAMKMKTLLPYLGGLLKIETYNDGSEGRLNHMCGADFVKIYQKAPEGIPLDVGVRCVSFDGDADRVIYFYHDENLVFHLLDGDKIATLVASYLKELLDAAMLSLNMVIVQTAYANGSSTNYITNVLKVPVKCVPTGIKHLHREAQKADIGIYFEANGHGTVLFSEKAQQAIQDLANDSNQYVERQQAAKKLLYTIDLINQTVGDAISDMLLVETVLHAKGICAPEWNSFYTELPNRQLKVHVANRNVITTTNAERRCLSPSDLQPAIDQLVQSYHNGRAFVRPSGTEDIIRVYAEASTQDAANKLAYEVGMKVYELAGGIGEKPKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG80</accession>
    <name>A0A9D4QG80_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG80"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030263"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="420" mass="46360" checksum="EA8E866C13CB520B" modified="2023-05-03" version="1">MADTGTTVLDTMSKEVNDLFRKGLELDHETGKQSCLTDMCSTHGAKLKYKEITKKEAAVLRRMLSTGPPVRTLSVFNISLFTFRVAFYELEECPSLKKVYIHIDCNGKDLGTSLSAAFRCLRTLELRCENTGTGFAKDVADYIRQNKSLREIVIWNSCGGDEGAATLAEALAANDSLKTFSLAEVELSSDILIGFAKMLATNSTLEVVNLKHVCPVEKDKVCWLTAQKRYAGVFKRLDIQWTEELLPVLAALIRKQACCPELFVSVTSSIEEGVVEEFSDALAAAATLRRLVIESDIAVADALHDRFYADATASALRKTVLHQIWGDMGANRGKERHLVSILDALKTNCSIEEFTMWAVMEGADALRKLRSSAPLVEEVKELTGKTTDAVLGEIQSSLARLTVCENMEDTSTSLAPHRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGU4</accession>
    <name>A0A9D4QGU4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGU4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="13484" checksum="FD5583AAFFC45914" modified="2023-05-03" version="1">MEPDETAQGLPKDELRTTEWKRRRQKKIWRVVQNQRFYDRVSLGDCQATSAKTRRENRSCGQGLEPCRRNDTGTAPGDPQARPKFCVEPRLSTVEKEYEEWVQNPSRMKTQMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJ33</accession>
    <name>A0A9D4QJ33_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJ33"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="237" mass="26214" checksum="B5F7E439943FB4A6" modified="2023-05-03" version="1">MENMEKENKELREELTRARKQNEKSMRKIEELQQTLNELLKRMGGPSGGIPSSCTSAPRRAAERGDATATGGEEGEKDMCCGGEDEAPAAVGSKRKSPSDAQPSKDADNHAQEPKRPRPGGRKIDAMEEIVNKLTNKTERMFETLLTRLNESDAERNAQYAAVNTQLAAVNKRIEDLERGTVQLQQQQQERHEPAGAGLPLQVVNVPTILNRGHNANATHNERRDARIVASPPNTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QK08</accession>
    <name>A0A9D4QK08_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_002860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ZFTRAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QK08"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051795"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22861">
        <property type="entry name" value="CYHR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16505">
        <property type="entry name" value="RING-HC_CYHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039338">
        <property type="entry name" value="ZFTRAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059:SF4">
        <property type="entry name" value="ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="265"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7982065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="558" mass="62649" checksum="B9511389A0A981E7" modified="2023-05-03" version="1">MVAYRKTSFAHALAFSEQPLLPGEIFLLEIAQNERGWSGHMRLGLTQHNPGRHFPLPQYALPDLANMGHSWVFAIHNSEMDSEHLGSSPYERLDPSTSVLGTGEHIYTSRGVVPRSMLLPTKRPRVPVGGEDSVTDFSGEGTSISSGPGSCGKSSILPTDVGSRIGVMYVTRGQSADMHFIINGEDQLYATDIPHQDAPLYAVVDVYGTTKHVRIVQLYGELAESTSDECLAEPDGPAKKRFKAGERTPGKSDKLEHRLGGILCCAVCLDLPRTAIYQCTNGHLMCAGCFTHLLADARLRDETATCPNCRTVISRELCSRNLAVEKAVCELPTECQFCASELPRSQIERHEADLCEERLTRCHYSRIGCQWRGPYHELEVHTQVCSHPHKSGGEVMEALELIDQQMHKEQMLYNTIFELLSFEKITFNDLQFKPYRTDEFIHKLYYETSRFTAFGSQWVVKARVNDNQRDPTQSCERTLSYHLVLKSKASASMGIHYMVLKGPFGDLKVNPRLYQHEFTEAAMESPYQPLPLLDSAECNKLLAAKAFNFRLIMFHVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQX7</accession>
    <name>A0A9D4SQX7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQX7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="19592" checksum="02B0670868F663AD" modified="2023-05-03" version="1">MPPTPPHHSHSSEPNAGASYSPSRREAGKLDSSSSRMQTARRAKHAEDNGTPSERRVAAEDAGLRPLREVTRKTGPPLNDQMDTEDTSDDGVGARDARDDEGNAEWSLFTKRKPIRKVKPEQLRLERVRPDQTIDYIMDHLRCETATILDARRLGKTNMLLLTFNTPSPPNEARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQY1</accession>
    <name>A0A9D4SQY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039806"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="602" mass="67430" checksum="8A9C5572E025E026" modified="2023-05-03" version="1">MARKKGETVKPSPVQSAQHVLDRLNDFLVRNPSSSLLGELYQTLVSSDGVEQVAAIKKLSAALKESLFMSDSDLSKISHNVENLLYCLSEPLVLSYLKQVLNLGIETITTSSGDTQVVGDCYQLLAKVVKAVGLLVQFASGQRKNCPVQPRAEALMVWTEEIFPSLLHLLKSDSSILTCKLSTGTVLPLILRVRNEGQLQKAFDPWPKDWFRESPLAEVCFLGGLVSGLSEEELLQTDEDNRTVLLHILLKRALIVHERQAHHLSITCAVSQHARLIFRGIVDMNILLASSEQEARAFLEESAMFLIDLPWHRKGKYDTVAYLAEVMGCSALLRLRPALVTSLLSAAEEPTMCSYVKDLVQKLASLHRKEACTAEFERAWLEPFSMATKNHSRELLVPLFQHVLPVLTAIHPGTTQYVFGKLSEDRSDFVPATLKCLLLDKALIESGNLERWRHVLLQGMSHMDVQVRLDTLQLLTEHPKSCEPVKPLCLQLLRSFLHLNINMQGAPFRQQMISCIKKVLNRIFDSSTLLNRQLRRGELPEEHAQLVPPQLEAHQEFVTWLHGMCMEQLFPGANFGRRFTALAILEVLVTVHAAKGQPALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS26</accession>
    <name>A0A9D4SS26_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS26"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9382" checksum="F00CE9C940615EF3" modified="2023-05-03" version="1">MPRAKSSIRTKEVVSALREAGLKLLMSDKEGGFVVMTSGTYAEKAGEAVKIQDVTLSSDDVFKAFRQVGPKKCLDQTGRATVWLGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS66</accession>
    <name>A0A9D4SS66_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS66"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="26151" checksum="79D9B598170B966F" modified="2023-05-03" version="1">MKLDALWKMVKSGKVHRASRRQRGLPPEAPEQPTDTVTMTSPQAVMEVPTNNIEWIREIVRSVVREEIQKLYGPRQPEVGSIASVIRDEVQQVLHNRHYQLMPTNVEPAPVSTDIRSRTYAEALRMPVSSLPVASPAVPIQMMPPNIPFDTAYELAITAETAAKQQEVTRSNVQETEFQLKLTVKVEMEASKKKGKMQQRCFGGLEPLQDGVADTRILCASAASEKGIQEKHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSE2</accession>
    <name>A0A9D4SSE2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSE2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039985"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="20517" checksum="10065CCCC7E489BD" modified="2023-05-03" version="1">MVTFNGYFGCTWCLMRGEHKEGSLRYTMGLPAEARTTSRVKEDMKLTATVKDTVNGLKGPTALMNLKALPIIKFMMEMVEILVGMMDNVVYMVGVMVDIVGPLVGVLGKLVVWWTLGGHNGWVVETQSWWVVEQLVGVLGGCRDASCLVGDPVGKVGSLVPLSGAMVNLYHNINFFSAEIGSRMEIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSG3</accession>
    <name>A0A9D4SSG3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054740"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="412" mass="43368" checksum="58BC428F71225387" modified="2023-05-03" version="1">MPPQRKGAQGRGRKKTQQSTPSAGEGTPQTAGQEPAASTSRGLGHANITLKASTGQPAPDGQATPSSPPEQSRAYRSDGEQHQEMPAPELPLKRKRGQPPKTNKVAPKQSKVGASGSSSNPPAASPNEETQVAPPPADSSQLETVEAGSAEPSMRVVDRSAVSSGAKGMEGRYITRSLSKSMEEPDVERSTASEGVRASGRARKVQRTPSGVAADGLSTKKRAIRRRSPPGTQREAAVTTAPHSSPRGDVSQAQNVPTNSISVVAPGPSGQRVSKALSKSRTEKAPTNEHAEEIHRNVRTGGSGSDQQGLSSGVVAKAPRVHQQGKKVDAPEGHTNETSANHFALASEDRKTPPAMRSPASPRPKAILSSSRLSSRRKLSFEKDALRSSTLEKGTRNIQVNAHTSKHQLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUW0</accession>
    <name>A0A9D4SUW0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031409"/>
    <dbReference type="OMA" id="NIFMHRI"/>
    <dbReference type="OrthoDB" id="6499091at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038745722" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16638" checksum="9F2A17A3D3895B43" modified="2023-05-03" version="1">MARAVLFVLTVFVAVLAVQAAVLKDGPRTAKSSADARVAEAARRERLVDEIRRQQELLELSADHLGDDTEEHRFRRLLEKFVYALNVRTIVGAMRDTITGEITPAHIIAKTNEVLGEASSLAIGIVQFLKNMGPLTFKIFMHRILTGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV67</accession>
    <name>A0A9D4SV67_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV67"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035657"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25114" checksum="B8CCBDF2C31AC5B4" modified="2023-05-03" version="1">MTYVQDDKRGSSAVVPRRQSEKEEGDSDFDADTDVDANDEDYDTEEEIQKVMQRQQKQETEASKHVGSDADPFVGDASGLDDASAIPLDLPDLPAFFTGKTFLLYGDFPADERRALTRYIVGHDGDLKEDLDDTVKFVITKSEWNDNFDETGGEKYVLRVIGAVLASGNIPRRRCPWQAAESVRRNIRLAVLELDGVGVVAQVEGPPLDPGCRCGWNWLTWVENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVL7</accession>
    <name>A0A9D4SVL7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVL7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="12031" checksum="1D032480B743751C" modified="2023-05-03" version="1">MAGPEGGTRLQRGSELCRRLFVEDSVHDRFVERVVAETRKIVTGGPLDRSNLPRSAEPQAAPGRSKTKSCKADAKLESTNQLRRTEERNGHSQMKSGTMNREMGLFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVY2</accession>
    <name>A0A9D4SVY2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_001041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVY2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="330"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7955491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="675" mass="73277" checksum="6DCD4201E5980EB9" modified="2023-05-03" version="1">MKCTSAIPLQSRAQAAATLLIGYSAPLYTLPVYSRKHSEARCAYCLLVLAVWTLMQVLPAPVACMFPPLVLAASNTIVDDDAIAAYTSPYILHVVAIMLFIRLGHSFGLFDRAAMVVIRLKGTRVRSLMFVFSGLSLLAALFLDNGVTTLLMAALIERATKALQDSTIQAHQKKARGLLLFIRAVHPATHGLSRNRRKTLEDLLMRGTEHTDVTSCHSPGLQQLDQQYSAAPCDEPANDDNAATQACDPYCAKHYPSLTPIVKTTIKPSLASNSKFRVYEANEPPRRISIMERGHVVLPGISSPTPPRVVRCSGNTGASFCTRYTLLHRDLLLGAVMVAVIGSIFSPRGNTANVLLFSYLQIWVLVIFPVVGCGLLACLSVMYFAIVRHQDAEEDENARLEILKIIEKQSEGLGTLTPVERLVIVAFILAATLWLAIHVIAFFDNDGRFAILSDHETLALDYLLVALLSSAASQWPVGRTEASAAASGASSALDWRTLVASILWGPLIIYGSVSCMGRALQVSGAVYWIQALLNEFNLFPPTMIQIVLTVLSCVFTEFVSIDVAVATLLPIVALMIPCNPLYFAIPVAVASSTTLVLPTAAMPIAILDDVLPPCRREMLIQGTVLKVVTLTSLIISMNTVGETLFSWSELPSWAQQQPAPNASSVVAIRQLLWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX62</accession>
    <name>A0A9D4SX62_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX62"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025909"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048433"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="203" mass="22378" checksum="478B405E93551D33" modified="2023-05-03" version="1">MTDGAEPIRGGSFLKMLFNIQKDMLVKPLRLLSRSHVEPSNLEKMVCRATLIFSSAVVAILEYIKEKPRLKYVLTRGLNSDPVESVFSCFRQFNGGNDRVDARAAVFTAEMLFNVGILQAARNGNAPSSSECKTPLKGGNHTSAPARLAMPDTALAVLWKLQHVMKHDVVPPTIEFTPLACMAGYLAFICEKKVNFPMTALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXI5</accession>
    <name>A0A9D4SXI5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_003946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXI5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7955820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="246" mass="28191" checksum="F9010EDE616AA29B" modified="2023-05-03" version="1">MHLTSSARSASVVPGCRHFGRSGWLEALTVTHLNSKTLNFNPMSHRMLPRVDFTDIKDYLVHETSFVSREQLNAYKSMHGHNYLMSGWVQQPGVKTAKMASMPGDAIATSRIKTQPAKNVKRPAKAKSKGKKKKVQTKFVIDCTHPVEDGIMKVAEFDSYLRERIKYNGKTNNLSGVITVDKDKNKVTVTAEVPFSKRYLKYLTKKYLKKNNLRDWLRVVATTKDAFELRYFQINNEEEEDDEDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY29</accession>
    <name>A0A9D4SY29_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY29"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10907" checksum="D735D61E8DBFF674" modified="2023-05-03" version="1">MFSLDECKSLCDSGGEWTSDLARVPKLSERVMEAHFVSSNRQQHKGQNRLPVQTLVDITFRKHVINKAVPAKRAGILHGVILRSVQRGVHLPHSLGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYH1</accession>
    <name>A0A9D4SYH1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049101"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="27181" checksum="2056F03889324215" modified="2023-05-03" version="1">MKLPSKENVVAGKATGTVSPVASQPRESVPTANQACINERPGFITGTSGDRMRDEKMAYARDIGAPQARGLAPQGGEKVMLATIYTKEEELSTTSEEQPPRMSGWLPESFQRVIDSGMEKIYGPRPRRPYRPPMLEMEVEEDDYDPYFERHEAVQVLCKPEEGRVMYPNEKRRRTRRSVYPAEEDFEVMFQDELVMGGGRRPMMYDDEGDPGYADEGDMYDEETEDVLYIGRHDVPGGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ52</accession>
    <name>A0A9D4SZ52_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ52"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12510" checksum="D6843D28741F15E1" modified="2023-05-03" version="1">MTVLAWGNSIGVIFENRNRQVYSRKLLRKVLYLLLGFGIPYTLKLAQSGGVMSLKWTTMIGILYGTITTTLVSTLVAMIIMRFHVKRAFGALLVLVYVLYTVAAILIEAKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZZ9</accession>
    <name>A0A9D4SZZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043760"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="301" mass="34043" checksum="BB17137D73C64195" modified="2023-05-03" version="1">MATATPQSLEIDIPTLSPVAWQKMYVLPREFDPKWIRMVTRSRGLVASDDAVACLLGFVEFVCGADFEKVRNGADKDGLLLRELKVLIVEPLHEQMPDSEPAATMDDFFVLLGTMLCTLSRPRSSYTNNVWFQKWANDLVVLFPNFSELLPVPVYVAIAAFGEQWPQTRAAICSIILKGRFQRYPWVIDHIPDLIFKQDSLEAFLEVYQRLGADGPYMKLLNLPVAATAQREFLDLHTAAGYALAVIQDPCVYRGAPYDRAEAEVFAQVFMMHRYIQFPVEADASSVPAETADDYRLPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0K5</accession>
    <name>A0A9D4T0K5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0K5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="477" mass="53715" checksum="9D400854FC6D241B" modified="2023-05-03" version="1">MPEGFTVIAHKKDPSALVLVRRPPFDICPMCVTKFVVAAYCQATAYHFTLVSVYAPPHKPIEPVLQTLEEVVAMSRSPNIVFAGDLNAKHRAWGPRAGDDRGARVAEFASATGLVFLKDPESEPTYETAYASSWIDAICPRGGLHLAIQIGDTRNEKRKRLTRYAQSELLGALAQEPWFSRVTKSQPASSEALEYILAGFYRVFNHHLKRHLRPVKGRVGGRSWWTPDLALQRKCVNAKRRRFQRCADPTLRSFLKQDYSASLAQFRLRVKEAKRAYEAECHSACSRANISSQSYREAFGKTRPPRLLPPLEREDGTLTSTHLESAALLLRTQIAVDSTATDPLSHTVIRQLASAPYDSSAQDVPFTENEVSDVIAHMPPSSSPGPDFITPLLMKGLFRVQTRFVMFVLNAALRLGYFPHCWRTGRIIFIPKPGRPPQRTTSYRPICVNSVFGKTLERLLNGRIYYILWHNGFIHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0U9</accession>
    <name>A0A9D4T0U9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0U9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035998"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="490" mass="54605" checksum="45254944D82CEA2B" modified="2023-05-03" version="1">MLLMEANHRESGLERHRTADPCSTDFQKEAGPCRSAPLPAVRLRWPRLAPLSGSDERAAARSTAHVHGPRRDGRSTPTSLGFALAASAMSRYYWCIFGSGHRCVSPELCAPVMSGAPPDKPGSSSDKPGSSSDKHGGSDRHASSSRSDDKSKEKALEKTTESIVDRGNAKERMVEVVRWYLSAFHAGRKGDLAKKPYNPILGEIFRCYWRIGDKAGDPVPDGPVPWATTNDLCFIAEQVSHHPPVSAFYAEHAGKGICCCAHIWTKSKFLGMSIGVHNIGQGTIWFMRHDEEYTVNFPSGYGRSIFTVPWIELGGTVNINCEKTGYSCTIEFLTKPLIGGKKHQLTAEIYPPNDKRPFLTVSGEWNGVMTAKNIHGTEVTFVDTHTMPITRKIVQPIKDQVAYESRRLWKDVTLNLKRKDVDKATEFKSQLEDRQRKEAAARKESNTKWETRVFEPDGDGWTYKYPLQKRLGIKRRGPKETTSTTPSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2D6</accession>
    <name>A0A9D4T2D6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2D6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028800"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17222" checksum="7EDBBBF85AA8B5E2" modified="2023-05-03" version="1">MPRFMRATQRTRLLLVVVVAFTVLFICGVAEDNDRRAAVRSTLATGGEASVAGDALSVATAAAEDLRPSVTEVVHGGAALVRGDSSASVAAIGMVHQQESVEQRQSAAVWQGQAVTVVGLLGLTVFAVIVAVVGRKLYRSRRERRNGEFTDVHRTSLTTPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4Z2</accession>
    <name>A0A9D4T4Z2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
            <ecNumber evidence="9">3.1.4.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="42" type="ORF">HPB52_004652</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="42" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="42">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="42" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="42">Rsan-2018</strain>
            <tissue evidence="42">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:138663"/>
            <dbReference type="ChEBI" id="CHEBI:140452"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:56465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85291"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:45533"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1-acyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52640"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:85216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:53165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85334"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:45597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45592"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:85335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:45593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45528"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85277"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:45529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56548"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:140532"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:56549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-butanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85298"/>
            <dbReference type="ChEBI" id="CHEBI:85304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:45621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-decanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85295"/>
            <dbReference type="ChEBI" id="CHEBI:85301"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:45609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-dodecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85263"/>
            <dbReference type="ChEBI" id="CHEBI:85294"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:45557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45540"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:78097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:45541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45616"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85297"/>
            <dbReference type="ChEBI" id="CHEBI:85303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:45617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85292"/>
            <dbReference type="ChEBI" id="CHEBI:85299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:45537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85296"/>
            <dbReference type="ChEBI" id="CHEBI:85302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:45613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-tetradecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85262"/>
            <dbReference type="ChEBI" id="CHEBI:85293"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:45553"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAPE-PLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="42">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.54" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4Z2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047329"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000016">
        <property type="entry name" value="N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="22" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="43" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="41">
        <location>
            <begin position="252"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="40">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="40">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="40">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="40">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00016017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00047926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00049463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="EMBL" id="KAH7975732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="508" mass="56861" checksum="F5DF55867F01B1D4" modified="2023-05-03" version="1">MLNAVRICRAALGPTSAAAIASSAVVSAAPKNVVFSEVTALSPHASNMREMSSRSRSGRPQAQPRRSEPPSPQPKSGTTSPSDTSDYHSDQSLGSGDLQQQQLRPAVIRRCSLICSSGSDQFTFDSRADPNDPGTPRVRTPVPSGRSSGSDFPGVHTIKRNTLLHPEGQANLQRSVCVNGRFQNPWPTWRPPTVTNIFKFGLSRDNSNVPPKQELDLVLPVLKPRFQDPPVEGVRITWLGHSTALLQMKGVNVLTDPMLSERASPSQLLGPKRFREAPCTVADLPRIDAVVISHNHYDHLDLNTVHQLNARFEETLRWFVPLGLTTWMEQLGCENVVELDWWHEGHLATEDNDLSFVFVPAQHWCKRTISDDNKVLWGGWCVISPEYRFYFAGDTGYCDVFKQIGQTYGPFDLAAIPIGAYEPRWFMKYQHVNPEEAVLIHKDVRSRASLAVHWGTFTLANEYYLDPPVKLRESLDRHGISPREFFTLKHGESRLLHAAPPNRTSQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T572</accession>
    <name>A0A9D4T572_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T572"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="233" mass="24546" checksum="CFB1D0216C747276" modified="2023-05-03" version="1">MAADEADLQPLFTLSRVAANRQQFEAAVTATAQSDPAANISQGDLICFDEGGATHEALPPLDCPLEGARHITPSPLSERAESMEPQRHTGSTHSAPVPDLTGQSESPQVLKDALRLIEALTGVVKATGDGGTVAKRREAQHAKPERGRPPSAIAATIQGISPEIVGNPQAESTRFQETSGATGVLFVLKGTTPCRRNPCVVGSVAEPLEFDAATLRLPTSSRQVTAPQPRLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T574</accession>
    <name>A0A9D4T574_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T574"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042851"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="22209" checksum="6FDB64A5F6CEB2FB" modified="2023-05-03" version="1">MECTAENEEDERDIGRTSRYIYITRNPYDCCVSFYYHTKGDPDSHFGNGTFDEFLDLFLEGQVDFGDYFEHVMSWYERRFDDNVLFVAYEDLKRDTAEWIIRIAEFIGKKYGCELRQNKTALERVINNTSVQHMQSGENEAYRKRKEDMKYISEDKKPRWMKVTEERLGEAIKKPITGDLVRKGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5A9</accession>
    <name>A0A9D4T5A9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5A9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056134"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="501" mass="56245" checksum="C08441F3391AD9D5" modified="2023-05-03" version="1">MSPQDLMRKAIEELGDPDELANNEDLIILKLEPAFTNKWTLPDDIKLSDDARRLSMGQRAFITHRALLGNLRYSGALFAGCRAFSSLRPLLETAKYVLKNVRSLVLVHNRNQIIDLITWFPTVNTVILYHNLRWNFDNDLMINEGSTKSCRMEQLLGNTPAMGSENLNLRSDTLVNLLKRCPRLAVVMSTNMEAALSSDAVVKAASKRLPVPFRRKELFLGSTFTHHTGILLVISTTSAEELEEAHRHFGEVEHLDLTAESESAIGKVASYTKVTHLSLVASLPKDKCSFEPHVTEVLSALRLVHLSLKRFCGVKLSVIANLCPHLKFLGISMCDVDGEEDVAADFPNLEHLRLGCAMKDESFFKLLRSCPGLRELDLEWDELTTAFVVGPPESYGERPRLEHVERLTLRTNCDVESGLDTRRDLPSDLDLTLACVPSLQRVRSDSYEIRTEEKVESEREAGPTTAIIGFESWKGEKPVSAEKPENRQQLHEAGEPHQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T647</accession>
    <name>A0A9D4T647_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_018468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T647"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052587"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="509"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="816" mass="92359" checksum="4C1C86B1CF755EFB" modified="2023-05-03" version="1">MKRKISEIPFAIESLEQLAQQVLSDAKSRKHGWSSEVVHAVKQLPSSPVELGAVTDLIWERILLEQQQKTWAFGAVLGVSLVASVLVGAVSLMLAPAGLLCDQSAAAAAKLGFLSYLTGKYLSPANCKVEFDWKEPQVVGNTLTFFIKFFQRNGRSYPICDEDPLLVEIVAGNGAHKVACSVELGGTDPNLANQARVQFTVRRAGLCHVSVLIGMVHVRGSPFVKNFLPGRPDPQKTGFIHHSCTVVCTQDEPHHLFLEPRDKYNNACLVDTTTDPSDEYSVDIIEVIAFRISLFHHSLERITSFISQYCVLYIGLGTSLSNGDFHVIVLSKSDAALVRKNVAKKSHNIWYEAKLIAMNCEKLSKPKKVFVYISPKQLTIKEYVLRIIPKRLITFRLCPSTKFQFKGSNNHEGEPVLVVDDGCQPQIEMVCEERDVIAATFTQFLLKNIVRKLHQKHYHDKLQLKVSRDKILDSVSRLLHLQSFLDESEMTPFFQSCYYGFQLLRSFCNSLFFFAGVIFEAPFLISDNPQVHPNPRRPAHLKLKHYEYAGRIVSKCLYESSLGSGYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYVTKIKYILENDVDDMELYFSEEEYTSSGQLLKTTELIPGGSKIRVTNQNKLMYLDALAQYRLATSVREEVEYFLKGLNELIPENLLCIFDENELELLMCGTGQFSIADFKANHTVSGFSFEFRKVLDWFWTAVSNFTEEEMARLLQFTTGCSQLPPGGFAELNPRFHLSAAPTFGSLPTAHTCFNQLCLPDYDSYEQFERALRLSINEGTEGFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6S6</accession>
    <name>A0A9D4T6S6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6S6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029499"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="15962" checksum="6858B6ACCC6D4880" modified="2023-05-03" version="1">MALWIEKATEENGALGGSGSPGHESPHIPANASSMGCKLPDQTAVRKVSGVEEHRDNYPLDNDVPAQDSGTDAAPQTPSILEPTYIRLPEGSASVAECYGVEEHRDNSPVDNSIPAPEAGADAASQAPPAAQAPTINSVPDVDSEVQAKIEIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6V8</accession>
    <name>A0A9D4T6V8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6V8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047532"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7977021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11638" checksum="A8070B6B9CF960EC" modified="2023-05-03" version="1">MPKQSPGQVFAGLDLLTKLLAPNPRAVRARPVIEVLENQCASDEPPEVDWHVEQAPWTPEDEVSLLGGRKYGFDRQRTGVIARIKVLPFWLLCPTVTIQYLMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T893</accession>
    <name>A0A9D4T893_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T893"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049722"/>
    <dbReference type="OMA" id="VQGMYTI"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7981860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="19402" checksum="EF1CCD110BAAECA3" modified="2023-05-03" version="1">MANAGNIRGGYGRAAFGGLGAVGVGFGGGRGYLAGGGGGYYGGGYRAYEDNRPRPYNFGYVAQAVGGSSSRQEVGDGNGAVQGVYTITTAEGGQRKVKYTADAAGFRAVVDTNEPGTQSESPADVALRSSSPPAYLLAAKYGPTGSSYAGVRPRAVYGGGGAAAYGASGLYGGLGGRGVGAYAGGAGVGLHGKHGGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8P3</accession>
    <name>A0A9D4T8P3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8P3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="7870" checksum="A42A3197FC4C8133" modified="2023-05-03" version="1">MRGVVSPSFRSSGRPPMLSNDGRRPDKSIGKRFPAKHVGKPLVPVRAGSPSACLSHLSRGGFTRPTRDGDVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA34</accession>
    <name>A0A9D4TA34_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_013399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA34"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037827"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="116"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7983664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="535" mass="58971" checksum="B7AC1123B25B3CBB" modified="2023-05-03" version="1">MPSRRKGTVSCSEAFASTAANGISAGAYYRRGPGGNFIQDSFHSSTDMPTYIAWQTLSTDLSERMRQGSVRLSRTNTLEYAPIAEDDEKTPLLNIQDAASFSKSSVSTPTVEQGVAWTVAAFLLVNSALGAGVLNYPAAYDRAGGILAATLLQILMICLNVVTMLILGYCADLNGDNTFHDVLLTTCGRRAQQIAAASILLSCYGVCITFLIVIGDQYDRLFTSLLGPLFCHEWYLNRQFTTCATAVLFILPLCYFQRLDFLKYASTLGIFVMLYPVFLTIFIFSTEELEIVTMKTKPDSLIDLVVILPVICFAYQAHEVVVPIYANMRDRRLANLAKATILTTAFLFIIYTLMGTFGYMAYGSVVKPDIMQMFDASNPWVLFGIVALIVKMVTTYPLLTFCGRGAFDGLYAEFTKLPAKEFIKGESRRRIFITTGWFLTTVGFATFTSNVGVVIDLLGCLAAANIFIFPEWLLTGLCLLGVFHQQEKFGLRRPMVAFAIGAVMVVIGSFIFGVVLLNTIMHDITEGDSHHLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA84</accession>
    <name>A0A9D4TA84_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_013415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036213"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14635" checksum="CB65C2F09C3BE383" modified="2023-05-03" version="1">MQVRLCKADGTWSGTEPFCQKYYRCNAGYTLIGPSERLCKPDGTWTAPSPSVKVVPVRESVPRPVPYKRRRRFAVGPLVVNTRVQYRGNAGYTLIGTMERVCQPDGSWSGTEPVCQGQRNRHCHYDPPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAE0</accession>
    <name>A0A9D4TAE0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HPB52_014596</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Rsan-2018</strain>
            <tissue evidence="20">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAE0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039074"/>
    <dbReference type="OMA" id="NGWIPVM"/>
    <dbReference type="OrthoDB" id="6428779at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="19">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7983821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="439" mass="50024" checksum="05F90102A3524435" modified="2023-05-03" version="1">MDDYRSSVLAPWAYAGILSTNGSLVALAIVCALLTIIVSALLFNRRPRRSPAEEVDERLRRRRYPKPTPPPFPNGWIPVMDSTELAVGQVKRLDVFGKQLSCHTPPPLPFLRASYNPSFPGKTLSPFVPKDGVAHVLDAYCPHLGAHLGVMGRVVDDCIECPFHGWKFQGDTGVCTHVPYASKVPDFVKIKKWTTDEILGLLFIWYHAESQPPSWYIGDVPEVASIDCSGSLRWRGENHISCHIQELAENAADVAHFDFLHGPSFLATGEHFFEQAEKTVCGSLLRHNWQTNWEPRDHTAQVNVVCRTSSPLRWISRVNEYSFTVTQIGPALVVTTMRTAFGNISYVLSLTPMKPFHVRAVHRYFPNSRMPRIVFWVIIWASKGMFARDIFVWNHKSYMKSPALVKEDRTILAFRKWFAQFYSPNSPSWRDVRDKTLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBY6</accession>
    <name>A0A9D4TBY6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBY6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38102" checksum="7939BDBEDD696ED3" modified="2023-05-03" version="1">MRIAAKQRVKLTWSGYTLAVKAGQQKKTLIQPKKEPSNLRSQTPRLSPSVTAQDFYDNVRVQTQKVENVTIASTASTERASKLQGINAIQLGRVIYEVNPHIRHPDDVCRGVIYGLEPGTTPAEIVAGLRVDSRYSVLGARMLGSSTAAVITFDGQHVPFYVTYVSGDYRWKPYRKSVQYCRTCGAIGHRQDICPQPKVNFCYKCGCDKDTEAHDCQPKCKICGEDHETAGKECKKKLRSNPPPHQVRQQQLDNARAQEQHWSLSTGDFPGMATTLESSQAPSLHQGPDRSRPHSNHNGKSWSRTRSQSRSAMQVSYESGDRQQRTQVSSNHQRIRHLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCG3</accession>
    <name>A0A9D4TCG3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_024418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001160">
        <property type="protein sequence ID" value="KAH7984957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052681"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="87"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7984957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="351" mass="38697" checksum="86CE0E6669B97D62" modified="2023-05-03" version="1">MREAGCVGCPPLNVVGTVARAFGALFFACAFQQQLMASLYIAALVVALACYAIHRAALPRVEDALAAEVILGVDGERGDGDNAAPLPPAFAHRGGGHDAPENTLAAIREAKRNNASGIEFDLSFTHDSVAVLFHDETLERTTNGEGPLASITFEDLRKLDAASKHPFAERFADERVPTLEEGVEECLRLGLRLILDVKEYDHRAVALVDELFRKRPELYRRALVASFYPQFIYALRRQNPGIVTALTWRPGFVAYEDIENLRPRFKSSYTKHLLARVGDWVLDRRSTADFSVPDRSLGRADLQERAERGVREVVERPGPPRPGVDPEPPGRKGVPAKGSKGAHHYRHPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD48</accession>
    <name>A0A9D4TD48_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_025275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010000630">
        <property type="protein sequence ID" value="KAH7985985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD48"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037900"/>
    <dbReference type="OMA" id="CAWASCH"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7985985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16639" checksum="EC0EF9811C1F528D" modified="2023-05-03" version="1">MNHVELSEDALDVGAVLAQVGSHDCGATSVFLGTTRNHCDGKPVYRVSYEAYAPMAKREMLRICEAIRERWAVKNIAIVHRLGDVPLGESSVLIAVSSEHRQEAMDASKYAIDELKRRVPIWKKEHYNDDHEQWKANKECFWTEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD87</accession>
    <name>A0A9D4TD87_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-secretase subunit PEN-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_025247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000611">
        <property type="protein sequence ID" value="KAH7986033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TD87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029850"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7986033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="8907" checksum="1F001269898DFF6B" modified="2023-05-03" version="1">MDLRKVKDDEKLRLCRWYYRGGFFALPFLWLVNAVWFFREAFIRQPFEEQKMIKAYVIRSAIAPRCGPSCWSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDD7</accession>
    <name>A0A9D4TDD7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_025193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000573">
        <property type="protein sequence ID" value="KAH7986133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDD7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052677"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7986133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="393" mass="42473" checksum="715D831C0C0709C7" modified="2023-05-03" version="1">MPNDGYRALIEDAPTQPSAVSAPSGTKSHCSRLCEIAIRIPHSRAHRRRSFRKDDVRYSIRTATLRSRRRRGACPELSFDLGSSPSCTPKGFLSSSIRALNTRKKRSKECYCSATDLMLPCAISTDATSTFESGLECSGSAPNTPAGCLNVTTSSGPMCRICHEGDQTESLMSLCRCSGTMGLLHVSCLETLAQCAKRGPLRALPPPLSHGCATHLLASVLPFGVARPLAADSSGRRVVLRDPDAVGRAQLLPVRQSAFKYAHEGRVMEAASLVTLAGLWLQATVWAFRTARFHYRAFAVWEAVNPMRRILAPPFSSGEGGHDRATAGQPTGLREMVDVVAGNAETERTTQRRGGGGQRLPLELPPNTLPEGSLPALQQPVYALGPMANFEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PA12</accession>
    <name>A0A9D4PA12_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PA12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033218"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7934974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="291" mass="31984" checksum="B51AB67C3202E377" modified="2023-05-03" version="1">MSSPPRAAEDDQGRSRRQLGPPPGNDLLEKAPATKEARPVKMTEAQLPTAFVLQRPLRDVAAINMLNDEAKLQWAYFTLDSLSGLRPAELNAVTLSNLRDTINAVVQEELRKVFPNSGPQVATLGDVVREEVQQALGTRPIVPPSQELEWAPRGPRMMPYPTGAPRPTDLRATATPTTKQLPTTCQITRSVSTTTNLPSFTVIIAFASPLPFTTPCQHRRTTGRLLVLTWQTEDGNQWTCGCCPAHPEDSPGPKILVEQHFLQRVREISDIFAPSSPEAATAHHDKPATPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB84</accession>
    <name>A0A9D4PB84_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053913"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF28">
        <property type="entry name" value="GH04176P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7934747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="165" mass="17810" checksum="69F06DE3712D839D" modified="2023-05-03" version="1">MSTTPDLLPAEAPAPRLCHLIKIPTFDGYGFNLHAEKSRPGQFIGKVDSGSPAELAGMLEGDRIVEVNGVNIASESHKQVVERIRAVPNETRLLVVDSATDAWYTEHKLVPRSTQDNVHYIRTPTTGDDDVVDGELQPPANGHHTAPETVAVEQQSASLPSAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCB2</accession>
    <name>A0A9D4PCB2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Doublesex- and mab-3-related transcription factor A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_018530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCB2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037337"/>
    <dbReference type="OMA" id="LYGCHDG"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
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        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="9">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7936129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="37744" checksum="7EF98626B98D3FB0" modified="2023-05-03" version="1">MSTSSGGSSGLGQPATVAAAGLLGLRVGVAGSAAAAAGLPIAERYQRTPKCARCRNHGVVSALKGHKRYCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEENEARELSLLYGCHDGLLAMHRAGYTFSAAMAQLLARDAAAAAAAAAVAAGGGSPSPTATTTSSTSSPPHGGGRLAAATAPPAVAATAAPDWKRGGGSGGPPSDASSSEEPSGSSGSPAPASSATEDGARCDDSDRSPSPDQPLALDTRSSQRRSPLDTLARLFPTRPQSTLAAVLDRCGGDVLQALDHLLLQEPPPPPLDYRRHPPPPPPPPVTAAATLLGAVPAYPGLFPPPPPPPASSAAAAAEHAKRMAALWSPQQAGDHHKSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCD9</accession>
    <name>A0A9D4PCD9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCD9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12945" checksum="0FFF9A3A9404FF86" modified="2023-05-03" version="1">MDYDSSEEEEILTVLMCSAIVSALAERKPSKKNRWWWVRPSLRSRDVAGHASRLLPDLRSHDEEYFRDFLRMPPRTFDTLLELLRPAISKQDTNYRPAISAHDRLAMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD96</accession>
    <name>A0A9D4PD96_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD96"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039230"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="361" mass="41087" checksum="022F19BD61B1ECA8" modified="2023-05-03" version="1">MLRGDKSRVVPAAERSPSKMLQLRNECRPFYAGFRIVGRAQRLLGCCFLENLASTDPQRVRAKRASLYLLYPLGIWCYHLAIGLALFVDSERHKHAMKDTDRLNKTIFVTFMAALHVEAVLNNVLLLVQAPKFVELLRICGLIEIHTAVPPYVQRKTVRFAWVMVLFQVTIIILNVALNIHSHFGTVLLIEEGRQLNPLLMNLAISNGFLGVMYLTSMCLSTRLLLMYISRAVALYLGCIYKNLDQCLRSRSTPESRKVLLVDHMRVQLALLKNCVDLASSLLGPSLLYAYAYSVAILCAAAYYTIIPELEFRVRLFFFFFGSLHWLSVLLPTITTHRMKAAVRLIIPYSVSTSFYRAYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDJ5</accession>
    <name>A0A9D4PDJ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDJ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7938981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="474" mass="49263" checksum="DF402D0417D3724D" modified="2023-05-03" version="1">MRSTSYFRLRGGPPGYSPPAPSRSSLRSTARAPQRFAVGARARPWLLMAFAAPPPKAHCFILNAPEGSTVDDVIDALEAVTGPAGIKSLQHMGGVKFSAAASSENAATKLKSRGAILLNGESVPLVSIGPEIVHVSVFRVPLWVGDAALASALSAYGNVQQVHEPAFKGRPGVGTGIRVARVEMKKPIPNFLSVQGHTVMCDYRGVKKVCSRCRLAGHIGKDCATPRCTRCGVFGHTTDGCTEPCRRCGGNHATVDCVRPRSFAAAAAGEQEGIDSLSTPMGSHGEQAPLEEASNEAVASDAESQGDIADLPHHSGAKSTAHQTQRETEEDTSSETCGDLSSPRPGATAALPSGGHEDTSSDAGSSTGSADAPRSSMGRGTRAATRTDAPFTGLEKINSRAGGLTAQTRRMNLSNPLHKITGPVAAASSGDCAMDVERQAVKRVHPSSTDSEGVLESKPQKLSNALAQSEHTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE14</accession>
    <name>A0A9D4PE14_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE14"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057766"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19420" checksum="009FF489517B92C7" modified="2023-05-03" version="1">MWARKDKDEGKKDAHTGAQTNKPNDRSVTDMDIFNGKTLVLKDGSEHAADKALGDAKAVALYFSAHWCPPCRMFTPVLAEAYKEMKEECAAPIEVVFISSDRSNADMLKYMEESHGAWYAVKFGDAFQQELKTKYGVSSIPTLIVIKRDGTVITANGRNDIQAEGPRAFVKWAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEF9</accession>
    <name>A0A9D4PEF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEF9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25166" checksum="11DB17BB6DAEC71C" modified="2023-05-03" version="1">MTLGFAIATHRDAAQAMPASKQKGSYRFLALQKMKVEEKSALEENCAVCELHFEDRYILREYVHIIDGKEVRIAHGVPALTPDAVPTVLPNAPKYLSTKLPPKRAPCKREAPTVPGPQNSKKACTSTPVDEDFESQGDVHDVSTAAAGAPRHARSQPIQFARSAPYSVNECRLSKSALFVMEALNVTRLFSFEEDSLRRIRALEQRAAAVAFREKKQMVITDFFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF30</accession>
    <name>A0A9D4PF30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_009430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025828"/>
    <dbReference type="OrthoDB" id="6477675at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039746009" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="25"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7939242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="537" mass="58572" checksum="268A25112CA0769D" modified="2023-05-03" version="1">MNGPVVLGLILKTLFSSLAYDVERPTKLGPVGGRRIQVLGTTIEEYRGIPYAEPPLGELRFKPPVPAQAWDGTLDASSLRTGCPQGHARDGLMGGDIEYGEDCLHLNIWTAEGHRKRPVLVWIHGGGFNYGSASYDNYTGAAIAAKTGLVVASLNYRLGVLGFLNADTPEAPGNVGFLDQNLALKWIKKNIRNFGGDPSRITLMGESAGAMSVHAHLLSPMSRGLFHRAVTMSGAMGTPDFSDPVHRSVSKGDAVAAIVGCRSADVTLDSQPDSVIDCLRNKSADELVVASSEAVPGKFFAFLPTYHDQFLPKVPAVAVRKGFFEARVDLLTGVTSDEGVTSLVWPRPWPELLSEKLDNMDRETLRSSITQVISSWMSDDAADLLDQYADRSTDQVGLRRQLLDYLSERLFVCPMHVAAAAHAARGGAVYSYVFDQWSSSRPSFSWAGVGHGMDLVYTFGLPLLRPEHFSDRDRKASENLISMIATFAERGVPEYPGSPPWPKYSSDSPVSLHLTHNNVTEVFGFRSENCALFSQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFE5</accession>
    <name>A0A9D4PFE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029555"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038633"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="191" mass="21180" checksum="BE008A3791B61521" modified="2023-05-03" version="1">MRTSFVLFFAFLFLFWRLRDYTTPLNEVAKVVGFTWIAAILSYVLSRLVWARAFVTEVSGEGRAVLITELSAVVANAGIGSTGLLEWLTMDTVVDVFNINVFGVLRVAKKFLPLLKKSKGRLVTVASPLGRFTVPMSVPYCMSKHAVVSMMDGLRRECHGKGVDFVTVEPSAYRTEIFKAGSTPMALVMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGD6</accession>
    <name>A0A9D4PGD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dermal papilla derived protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_008508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028311"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7939214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22694" checksum="CD8173041E830F7C" modified="2023-05-03" version="1">MEFPATFRRNNLAYAESVQHQSMYAFFLISGVVDVMYNAGFPFPPHTDYVALLLAVASEGLLFHFHLQGRMHLDVMVHMLLLYTMVALVTCLIAEMCRPRSVLASLGRAYFCLLHGTWLWQIAFILYNPLPGHKPWDVQSHMDSMLAASVFAWHMMAVLVYVGALGAVAWAVNRMCGSFCEDVLGAQEVGELREPFITRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGH9</accession>
    <name>A0A9D4PGH9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGH9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17615" checksum="F6322983AE995DCC" modified="2023-05-03" version="1">MSVTATTIANCFRHASFAAAPDASEEPLLDEPAVPDGFATSDEVAASWTALRDAGVVPDSESFCDYVSADSEVVATEQLPDDDIVRAVNDLDETSNDDSADERKTNVPTASEALDVVDVLRRYYGTHEGNEDGMNIAAAAERAIVRIRKMQQRPITDFFAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHQ0</accession>
    <name>A0A9D4PHQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_002265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHQ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057251"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7942903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41196" checksum="305C6BEEC5C780FB" modified="2023-05-03" version="1">MVCYFPAWSFFRQGRGHYTPEDIDPHLCTHIIYGSTSLDNDSLHLASADYIADGKLHLLNRTLALKAINRRLKVLLSLGGWKHGPDEDYKCSRFASNATARRRFVHHAATFVAEHRFDGLNVDWASFGGDECDDVSDKRNFVLLLQGIREALDAYDPHLLLTAAIAGNVDVIRKAYDVAEMFNQTDFTSVMAYDYFGSESPVVAHYSPLQSATGETNPEMSIEYVLNTLIAMGAPLAKLVLGVPFYARSYTLANPRLNYIGAPAKGKGEAGPVTATAGVLAYYEICSAIKAGGWTTMMDPRAGVYAYSGDQWVCFDGPRSLMRKARFALKMGLAGLMASDVSMDDFRGECGRKSPLLNAIHRVFHPQKTAAVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI14</accession>
    <name>A0A9D4PI14_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_022059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI14"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040839"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7940144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="491" mass="54498" checksum="16BB7A2A083D3DF6" modified="2023-05-03" version="1">MKDCLVDGATGGLTDAPMDVSEESLAGGLTLGVTNISTEALQETPADDGSRDGAATRSVAAVVAQSLEDAVAQVLGPAAGPLSEGLELASVQPVEESILPNEIDDATVIPLPEKLVTIHPNTDDATVVPVSEKLVTLLLPKLGGSAEEQQQLQCPACEFQAGYVQQLQEHLLGSHADSVVRCRRCPHVCLSRDTLIVHYRTQHPRCICPYCDHIAEQAYAIRRHMARHTQPGACTCPVCNKRYKDPYILKMHLKMVHMPAEVLFECSLCGKKFNRKAHLKRHARTHNPNKPLKCPRCDYRGCERSDITKHMLIHEEPKHVCNICNRSFRHAKNKELHLKRHKGQKDYKCGVCDFYGYTFTDIRKHIERRHADPHTILCDRCGQAFKSQALLKEHQMSAQCEVYLIEQELTEYEETAPECLLTTADESEPTDETLEETYVEAEAQLLELPGQQYAIVTTTADEADVEATAEVPDVAHETHIAVVQDASHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIG8</accession>
    <name>A0A9D4PIG8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038114"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="407" mass="45517" checksum="04457B4B2366E6FE" modified="2023-05-03" version="1">MGIRTNSTQMFPPDGLCEYLFYDSLYKEGRNTFDAPDQFDTNLRTFVEIAPTYKTTAFGIGLSYNAAPDLQSYLLEQVTKKFNVMQYFWNHSIHHIGVLDSATVDPREVDIKAALNCLKILRDDFSQEIISQGIKVFTFFAASIPNAAWARFYARNFKDLRMPDLYIALGHYSRGDNSLRTCVVVAPTQLRRPRGAEDSYQYDMTTAAESIVRLSGLKLKSALSVTLSGHLAVPTDPNNRGFLAPCMTNDSVDSFASYAELCTIKEEHTVTKFGIAVFDVDYADFSNVCKSRGGPFARLHLLRSVLNFFRTRAQAVTLRLLQTSTYPSPAALHTLHPERFPSPDCPVCGGYADSEHVLWGCASAGPPVTQGEMKRVIKTQDQTSQILAVQRARARAVRFNPMVPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIM2</accession>
    <name>A0A9D4PIM2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIM2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026916"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="78689" checksum="2C3046844E906105" modified="2023-05-03" version="1">MALFQPQANRYPNELHVPCTKNGDVNCQLLEHQVAINKVLRDIGLEIRADRRQVGGVHMAVSQTPVCDEFFTWWPDTWLKASSMNLAHDMIGSHRCFTALEMYSSTPWPKRVQRALKRVSAVKTLTVYLVHHHGYEARFHEGVFALVSSLTSLEELTFKTARDRHVGSIKHVSGQLQAQSLMHLTTLDVRNVLLESENTLAFFSALIDNRSVTDFAVDWRLLRGSLTVPAKLGSLCLPRRLAILRKLRLTDRVACWDRDLWLRLTEAFAEKATLEELHVKMKMPVEIYTTVSEGFAQVVLQCTNLQRLQLPTSSRESSSKLPEYDDKRWPASLIDALKATHSLRDLYISVAGTGETQLRSLFADVQTNQTLKNVIVWDGLNTYAGSLNIDLLCKLTSMESLGHVVSFGQELFVSNESSLKLVLLSELRSLKFFRLKFRLYYRCTVELLTCCKILCRRGARTIFEVCCVRESEQPDFCDWLAESSELTHVTVAAESHTSADCANMRDRVVAALANNSSIARLRLVEFKLKTAQLNMLCQNAREHRSLSEFVLTPACAISSQNCNGRSEVFRVALLQLQNVVSQNASRMSAAVKFVLGEDSGDGARAIEELRDHPWLPERVRDDAGLTDAEAQKKVKLAVNRVRNLNVHEFLWLTGVVRERRATPLDPDARGLHILEVPLVCWLYIRRYVNIADVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJY4</accession>
    <name>A0A9D4PJY4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJY4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22510" checksum="20C8338BD03F6DCF" modified="2023-05-03" version="1">MADSGSTSSTSAAGKGPRVSEGQRAMVLAFMEQHPQLALPAIDMGPNFTMADRRRQARQEVPRALARMKHWKGTLPGFRGRVLQLTGTLRLSGVGHLPYQEKHNIYHVVQQVWPLHVRPVRPPRRPRSQPRRVDTLSEMSAQCARWLEQGDEALEVLRRIEWSTTRLAIAAERTAAAQEAMLEEVRSLARGIGGLSLQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLH4</accession>
    <name>A0A9D4PLH4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLH4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052701"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF30">
        <property type="entry name" value="SUGAR BABY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="24"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7946809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="503" mass="54408" checksum="2DE03713F3006FD4" modified="2023-05-03" version="1">MTPTQPATACSWLPACVNRKLLPFKLHYFLFSAGEAGVTPYIAVVGRRNGIGPATLAVIFAIMPLTAVVFKPVCGFIIDRTRNVTAVILVLQVLCTIFYGIAFFCPSAISDGATYQGHLSCPLGEFDVIGSSGSERCPSSQFRNNKSLANDFLVVPGDMKCSCDAALHHNANFWIYAVSAILGFALTATLTNVSDAAVSNALGTDIELFGRQRLFGALSYGMTSPLIGYLVDVASSETFTDYRPCFYVFASAMLLDMILILYVPRIRVAEVSVSFFKDIAQLLSSPEILLFTFFTFLAGSFMGFLNAFETWFLEDLGTTTYLIGLTKTIQCFGAEPVLLFLSAYILRKIGYFYSYSVAFVLFACKAIGYSFLQDVWGLLAMNIVGGAIFPMVYAAMAVFAKKKARPGTAASMVCILGANYDGLGSAAGSLVGGLCIDKLGGSLTFRYIGFSSVAAALLSALCYLLLRCTADHESGNHVPSLSMYTFHVTHTAFLLRRYYTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLQ4</accession>
    <name>A0A9D4PLQ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLQ4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7946959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21612" checksum="BC1EA4EA6B9AD7D7" modified="2023-05-03" version="1">MNVLCSHLLSLPEGRLQYLDDERDLSLPKVRDKPERMAVGDIRGYLMRMPSLRRHLECVAHIYCFLVEQGAIQPWELYRINRRGNHAALVGDVLDSFLRRDSGCCTKITSTFSCTCLLTPDEEGWMVHTPCFFCIWPAPSCVAVHQPPPGYSPIASRALLQILGEQPDAFRCGIYQDLNEAHDAARRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN68</accession>
    <name>A0A9D4PN68_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_018643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN68"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052570"/>
    <dbReference type="OMA" id="ISPRICP"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7948108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30368" checksum="AD9F2EBC6E8B3EE5" modified="2023-05-03" version="1">MAFECGDEDILSLRVLRVKRDIADIVNDPPPGIYVAPEEKDITRIYALVMGPSDTPYEGAFLLFHIVCPHEYPIGPPRVRFLTTDAGRVTLHPNLYQNGDVSLSILGTYVGPQWSPAQSLCSVLISIQSLLTDDPFYDHLINGNHSKETYREAANNYKVYVRHEVVRVAVCDAVQSCLEDSSAYPAALRETVLKLFLDLYDRYEESVKSCLHLTGTQIQHPFISALGTYQYEALLARLQDLKAKVEKRSESGSRGQPVASGEELGHTVVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPQ5</accession>
    <name>A0A9D4PPQ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPQ5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18644" checksum="5B8E4DB40734535C" modified="2023-05-03" version="1">MAKASHRDSLILLGDFNAAHTEWGYLKDAAKGRRLIHATEQRNLTLMNLPNSPTRIGNSVECDTTPDLAFTNADRHTTWQRLEETLGSDHHIISIAICTGKMRRPLGKARITDWNKFRERQQDWSLDNGAPTNATEWEEAINGHSGNAAAHIQARAIVDRAQRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPX8</accession>
    <name>A0A9D4PPX8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPX8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="200"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="427"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7950954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="76940" checksum="CA2D4CE75410BB25" modified="2023-05-03" version="1">MSMATEDGSAAGGSSSKAAGGSYRRSGGGGFEGSSAAASGDSADTKAPFSRKGATVAAIVCVAGLIVLWLLVMGGSKKPTDPPPMHSPPPAMMRKPFMPHMTDRKGAAFPAPPHRLPEPAKPPSENLVPPSLVKPPHPAARLPKSPKPNDERTVPLVFPGSPAAATDGPNSLAERPYSPDDDYVPPPRSDFPEKLPLYVVPLHYDLMIKIVMDANRDQNFMFGDTYYLGKTIVLLRCVKPTQTVYLHAAGFTIKEQQTTLVREADKTFVGIGKMAINDELEMLKIETDSPLEHNESYSLSIEFAGAIRNIPRGIYKSYFVSDNERITVVATQFLPTYARWVFPCFDEPSLRTTFDLVVVRPNHYRSFSNMPLSKSEERSRDFVADYFDRTPPMATHNLGFVIGQYVTAGNGMIKVHGTPQQVRDADYALQVAPKILQYCQETFSLNYPIPKLDFVAAPILPAPAMDQWGLITFQDVYLTFRSDDTPFQMKVDSLRVIANKIAQQWMGNLVTMAWWDDMWLKEGISRYITYTAANRADPQTDVGFTVLESDAHLAMEADGFNSSAAVSRPLNTPADIRRHINVVTLSKGGALVRMMAHMVPSNLFRLALTELFKKYSYQSIHPQHLYKEIHTAQKAMYDRVTVNLTTVMREWTYNPGFPVVFVNRSYETNTFSLYQKRFIFGSGPVEKQVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQK1</accession>
    <name>A0A9D4PQK1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQK1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="192" mass="20511" checksum="828BE7959BE5C8E7" modified="2023-05-03" version="1">MGDELPPDFPPGYSLSGPNRSRAYDLLLKEASYLLRRDKATPTSGAPTERQKRTRAIKKSPGKARKHPQPEKTKKVNPRRTPASRASSSCADTPPLQIEAAASPFFPLPAPPTGHLFSGDASGSMPTHGEPATETCSASREAPSQESPPHSSTGILSTSWEESPVSSQESAPLSYPLSRVCWCLVRSSGCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRF1</accession>
    <name>A0A9D4PRF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_004722</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032023"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057737"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="491"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7951091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="836" mass="92356" checksum="29FA4E2696821BCE" modified="2023-05-03" version="1">MEARRAELERKRQKLEQLRMERLKKKEEKEKKDSRLNDVDDGPKSRSDHAIDPDELLSSLGITLTRDLSVSSVSTPPTGSPNASSTASSLDHQSLPTQQEPQQQQQAPAKVQKKPKLSICTVHQTNIPPRENVTYNKQTQTAPSGERDAHPLDYYVLTFGDVLAEEDGSSLGAVVEGALPLHEPHQHKVTGLPHIEPVRPAQTPAEGATDGHRAAAEQDKPKVPRELSEEERLQILLSDDFRSFLSRSARVIERALYENVDICIDYSGTTEEQDSDDKSGIKLSMNRVFADDRWSKNRIVTSFDWSSQFPELLVASYGNNYDSPNDPDGVCLVWNMKFKKTTPEYIFHCQSAVVSACFAKFHPNLIIGGTYSGQIALWDNRNSRRTPVQRSPLSAAAHTHPVYCVQVVGTQNAHNLVSVSTDGKFCTWSLDMLSAPQDVLDLTQQKQSRAIAVTSLSFPMGDCNNFIVGSEEGAVYTACRHGTKAGILEAFEGHQGPVTAVHSHGCQGQVDLSHLFLTSSFDWTVKLWSLKESKPIYSFEDNGDYVYDVRWSPVHPALFACVDGTGRLDLWNLNNDTELPTVSEVVDGSPALNRVIWTPSGHQVAVGDDAGKVWVYDVGEQLAVPKNDEWSRFVQSLQELKNNQADQELDSFNLAPTTVTLSSSSPLSSFANRASALSLLRPATAVPSACLAPMSAMSPKQEEATEYFFKKNKSLKRPLSPHLSIYAPQMTSMLSLTHRATGCAMAVGLYGMGVMPFMCSHNFPHYVEALQAMHISPILTFPVKLGLAFCLSYHTFNGMRHLAWDLGLGFSLKELYATGFFVIGLSLVMAVVLAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRQ6</accession>
    <name>A0A9D4PRQ6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRQ6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15755" checksum="A8759843A6C2187E" modified="2023-05-03" version="1">MSKPKPRSRSARIKPANKRRRLSSPESPEKTFCHIRARQHRMAGDKDATEGFHLCTGTACRTDEVVCSFSELQAVKGQLRRATQQLRRCQMKLAKMTVSANRHKRLDEDIQKLSAREKLIFHQWLMKANAKSPTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS70</accession>
    <name>A0A9D4PS70_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurexin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_018372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS70"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030097"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF91">
        <property type="entry name" value="NEUREXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="440"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="608"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="646"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7952094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="104512" checksum="37E47DA365E987BA" modified="2023-05-03" version="1">MDEPAQRLFRSPIWEFFERGASDATCCTCKMRLKTPTGTTTTLVNHLKRHPDPFKQFEKLLPEYKVPSRTTFSRSVMPDLYAKEKERIKDLLNDGQWHRLVLALQTNRIELHLDGVPSITTRLFSLETGGEYLIGGGVYGMQGFIGCMRYLYVEGRYINVLTLPPNQVQGQVLRDACQMVDRCHPNPCEHGGVCKQDSIEFVCNCTDTGYAGAVCHVSLHPLSCEAYHMKKKPDETMVNILIDVDGSGPLTPFPVECIFHPDNRSDTLVHHKNEMTTDVKGFREPGSFIQDIVYDAPMEQMVHLVNRSTVCRQRLTYECFNARLFDTSVQDTTPDTFSPYGWWVSRSNQRMDYWGGSIPGSRKCRCGLYGSCRDPQRWCNCDASVEEWLSDGGELTDRDYLPVRQLRFGDTGSASMQEDRKRGRYTLGPLECQGDALFDDVVTFRFTDSTIEVPHLNLRHSWDVYFHFKTTAENGVIMHSKGPTDYVKLVLIGGDQIQLLYETAGGGPQGVSVETSYKLSNNEWHSVHIERNRKEARIVVDGSQSAEVREKPDRSHALHLPGNLVIGASVDYKEGYVGCLRGFMVNGEPLNLRLRAPPGLYGVSLGCVGKCASNPCLNGGTCLEGYSGYTCDCQWTPFKGPICADEIGVNLRSDNYVRYDFETTLSTLEEYIRVGFTTTEHHGMIFGMSSRTGEYLNLMMSTSGHLRLVFDFGFERQELIIKNENFALGQIHDVQIKRTHNGERLTIFVDNYEPQVHTFNIRGKADAQFNDLLSIYVGRNESMGTGEGFVGCISRVQFDDHMPLRRYFQESRRSNVHAYPEGAVREDTCGIEPVTYAPPEDETRPPPTLPPGVYREPWAQERRVLAVILAAIVIMAIILGRYVSRHKGEYLTYEDSGAKDAPDADTAVVHGVRGHDVTKKREWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSR6</accession>
    <name>A0A9D4PSR6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030018"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032766"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035693"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039505604" evidence="2">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="429" mass="47458" checksum="E3C5AD7395A71829" modified="2023-05-03" version="1">MLLHIALAAAICMHTEATANIHANASTATTTVQQLPVEPSFREDCEKKGGRARVPEKWQQGPICDCGDWAAMDEAAGKCVQVPPEQTFCSPGTTWDDDDGCIEIEEENLCDSLLKDQENAYNGVNECVKAGDIFWFKCKQGYREVKVKTQGRLKRSICEVDPEAPTPPQDPCLTVGAEVCGDVRCEPYSDNSGFTCKCGIDFFFDATEKRCYNMKSCRVHKCERGLCVDQNGTFPASCQCNDYPDLQLNCREKIHKYVTSFRVNDTNSPSAEYAAGDCGDKHDMVEQAMQIVYGVSLTGVRILQCSDEYKVELNFGSEPPGVLLDKIRTCEHPDGNDDCFFPPALHIVKDSVSEQKCELYCTGPERQCVEGKCVCHVNYYKNAEGVCVHTQKKLTAVGVVLSVLIVICIGAAAVVIRRIKNRNSPCEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT65</accession>
    <name>A0A9D4PT65_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT65"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="17837" checksum="E814F9C8023E4843" modified="2023-05-03" version="1">MNPFRNWREEETGERCTGDRDVAEVGVVADAVCEDATRREGVVDPEKAADGANAHGADSEVEEGTDEVAYYEEGERKTRDGDWDEIECVDADDAKVVDDVNGAASAEDERAVAEASNNKAEKSEKPRAGELGLSGRMQISPDFSGERLEYFGLFCLESSFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTB8</accession>
    <name>A0A9D4PTB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gluzincin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051772"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81593" checksum="2B96DCD86D762CC5" modified="2023-05-03" version="1">MGVVVVSIVGSLLLLFDYLLRTANTFSCVGTKPCYLWTRVERAEVEQEPAADDRRPTKGRKASKEQQLFACSVVVLLSSVLVVAAALVTDQWSTNRVHVCHTTDCERHAVELTRRLVSTAGPCDDWSSFVCSTWRSEHPGAESALEDAAMHWSSRVASVVPEQVYYSSEARKAVHAIVACLDRSRENATESKQTLLEFLDRRTRDAKATSYHRDGSNESILAVVSLVAEVIDYAVNWMLPLLFNAALMTIHGSPRGRIIVLFPSELVPIWFKIVTEQRQHGTYDSTWKYITRATAGRTTYFDLDNGADIAEDVLGSLHNVTVLEPESSVVVTVGKFGKTLGLPPGKNLARAFRQTFAVSPEIEEDDVIFMSHRRLLATLVTLVDSHGANALIAFIRWWVLVIVGFLADSRSIRKHASDRDINEVMTLMCTTEVEATHGLALNAADKENFEEEELDGLREALENIKSTLEIGISRLVYLEDRAKEIIIAHLKSIKTELWGDVDDLKEGNESFPALADFPVADGPFLRYWLSIREHALSLNSALRYRLPYVQRRTMPNTLFRYEPFSKTVVLNHAALTAPYYYSAGTKAMLYGGIGFWYARTLVQALDYDPEGLFTPEYEKMGRQPSVTFNGKGVLKQCSDGAFYRDDFPEMAAMEVAHAALQRDDDHNRLPGAETLTPDHIFFMTLCYGSCRTEGKSRFSPSCNRAVLKSHIFAKLLRCKPKPILCGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU16</accession>
    <name>A0A9D4PU16_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU16"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="73" mass="8364" checksum="79C3A9D139D573F3" modified="2023-05-03" version="1">MWTAIAAELPHETGIERSPLQCENRLKTVNHRYNNARKRNRQSGVNPIEVPYADEMSKLAAVDYSVLPESQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU69</accession>
    <name>A0A9D4PU69_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU69"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039915"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000015">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFH" evidence="8">
        <location>
            <begin position="179"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="531"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="661" mass="71105" checksum="7105C660C230A015" modified="2023-05-03" version="1">MVVGSAIRQPRNIQPLIARPAPVRAGIAQSNAVALQAGGVMPGAVVFKTEDGQLQFVNVHPNSVQPVSPGPVASRGPFRVPAPPAPAPLQPQRVMQQIPARYAATAASMRNRPPGLALTPAGFVCVSQPQIMPPPSQSLGVKIVPAPTVAAVTQQLSIQTGPVTVGAHEAAANAPLMSPDTAKQKCRNFFSTLIRLASDQPENTAANVKRLIQGLVDDTMQPEEFTTKLERELSSNPQPCLIPFLRKSLPLLRHALLTNELSIEGIRPPPRSALCIPHPSPPIVRSVQKTAVARTVLPRAAAAQLQVMPQSALAAAQMAGPVDLQGLLAQQHRLTASVRPSPGGGVAPGGGKSLLLARPPNFAVALPPVAGGVLPFKIPAPVSTAAQPKASLSTSTGSVGGSGGPSSSAKEKRSVGPALIDEDINDVPTMGGVNVAEECRAILSTGDDGAEDRSCKDENFLFTDALHKRISALAAVHGIDEVPDDVVALVSHATQERLKTFIEKLSVIAEHRQENVRCDPRCEVTQDVRRQLRFLEELERAEKRRHEEEERELLLRAARSRAKVEDPEHLKLKQRARDLQRAELEEARQRETNMTALLAIGNRKRPVPVVAPGGGPGKQPFHAQMYRPRLKRVSTRDVLFLMEQERSKFSSEFIYKAYLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUB9</accession>
    <name>A0A9D4PUB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_023984</name>
        <name evidence="9" type="ORF">HPB52_025316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001982">
        <property type="protein sequence ID" value="KAH7931788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050042"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7931788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7952549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="24065" checksum="C8162470813FAADA" modified="2023-05-03" version="1">MSFIKQYIPSGTPLFLVGHSIGCHMVLEILKRAPDLNVLKAFLLFPAIESLDSCPRVSIINPLVTYLRPLTVASLSALRFLPRTVQNMLIRFYIYLATSCTTPHRTSLSGAQNYFRPECLMACFVFTRDIIQNVRERDDATIGRHADKLVVYYGQNDHWSPVEYYDNLRRTFPEADVRLCDRGFRHAFVLDCSVDVGNMVRGWIEPFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV03</accession>
    <name>A0A9D4PV03_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV03"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="343" mass="35938" checksum="C209F15C74DA9254" modified="2023-05-03" version="1">MLPRLCPPVPPFHSAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPPTRAVPPGPQPSHDRDLPSPATSLSTSRPATSAVVPAPDDPPDDFQYPTPEVPAPDDVAAAIDQSATSRVSSTPSADDPSGMPAIRPSSLSSPALDTSLTSASTLAALPNDLEVDTDNLSPAVRPSLAEVSPTTVLEHDLSPTSRLCVSCQQRSASPSTSPAAAVRAPHQLRPNMRDAATMTVSPEDDMPVSSKAAPHANVTPATTADVQYSDLRTGPHVPSTVDASPSAAAPSRSSEKCWSTEGQVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVB8</accession>
    <name>A0A9D4PVB8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVB8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="13098" checksum="B52A58F3E0FB4EAB" modified="2023-05-03" version="1">MQTARRAKHAEDNGTPSERRVAAEDAGLRPLREVTRKTGPPLNDQMDTEDTSDDGVGARDARDDEGNAEWSLFTKRKPIRKVKPEQLRLERRYRRRQSAGLKKHKRASPNNLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVE9</accession>
    <name>A0A9D4PVE9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVE9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047412"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18883" checksum="ABEC0BD4868B2D8F" modified="2023-05-03" version="1">MFDIVSQAATDVASTNATTQQALEVCQREAGRTALTVHGFTPNEAVEDDLGWSSFKMKEEVAKLAYERSLSSLTDSRWAWDTDEMGHPNLLAIGAGKSDIAEEVFYDNSRGSGLLCEARSGVFRMWTLRARFTAELDTTCPLCQDAEDTIRYIVLECTCLQAVVPGAQDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVJ5</accession>
    <name>A0A9D4PVJ5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVJ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050378"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="377" mass="43875" checksum="61D592076B02A687" modified="2023-05-03" version="1">MGVDGDSDDDQDGQRPKKLLYPLLCTTSSEACVEYAADLPPDGICTFIFYESVYKKGQHPNGDLMRDYQTPEFRRNLDYTWNKTIYQYGVASMRPPQITTNDIRDALTFIKHLDTYWRTKPNFTGIQPSTALGIPLPESQWPDLLDMMQKFFTPHIFIAISHISIDDYRLPECRIMPTSIYEFPPNVTDRYFQSVNDSGWLLQMIWDRGILSALSFSFTMRARWYWPRNPDPNVVAIGNFGLFNPCRDGGEVPDISPGKACNVSFWVRNSSRYDPTYFVRVGYDKSLGRTLVFDPLTGMRVKICTAKRIFLRVNFTVSAYDVEYDVWRYIHFRNSRKCDHFNVNATNERTQFLENIRGFLNRSYVTAPDVQDCITHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWQ1</accession>
    <name>A0A9D4PWQ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">galactosylxylosylprotein 3-beta-galactosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_003845</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.134" evidence="15"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWQ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045778"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7955773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="673" mass="79493" checksum="ECA7E10CB0F46140" modified="2023-05-03" version="1">MRYFRTKADRDPTKPRAHQCFNLVRPFWFLLGIACGILAWRYLRQRSGPTESSDPHDIAVFRDDVYEGAFLFVAVLSYQQNEALRDAARRTWLKRKVKYDRHRFPLVYRFFVGSLGVSKEQRIALEREALVHRDLVLLEGVPDSFDNRTFKVLQAFLWVHSNYKCKFLLKVNDNSFAMLDPIVSELGEARFNPRNNLLLWGFFAGYAPVSRSGPWAEPVWFLSDRYLPYPCGGGYVLTWMALVYISHIWKLLDLYANDDVAVGVWLAPLTLNRRHDRRFDTERESRGCLNSYLVTHQQTAAMMEEKYKNLMEHGVMCREEVQLRMSYEYDQHARLSQCCVRNRERAFLVGVIWFVLGFVFALWCCYDMAARSAKRWDSKEGEAFLFVAILSSHKTEHLRHAARRTWLKLAPASERRIAYKFFVAAKGVPPKWVEKLHREQRQYNDVEIIYEAADTYEKLTSKLLYSLQWVVKHYYFDFLLKLDDDSFARVDAIADELAQWKHDNPGRELYWGYFAGNAPVFTSGKWAERTWYLRDGYYLPYARGGGYVLSLGAARHIGTMGVIIFEQYSSEDVSVGVWTAPLRLERKHDRRFDTEYRSRGCFNSYLVTHKQTASMMYEMHRNLEQDRKPCQREMRWRLSYEYNWSVPPLQCCVRNMTDATLRRPRTFHLRHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWQ2</accession>
    <name>A0A9D4PWQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034568"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="40588" checksum="DCE87C93F7506D27" modified="2023-05-03" version="1">MTNYRTKYPADGVCDYIFYDSMYKNHRNTLPGVWAEDVLSILTKALQTDPAKTQFGMGFAFEHRHRLIQDLANTSLKHFWDYKVFHFGILDCPAHGTKQTDMDEVFVALKALDDSVQKARASGNTSYIVLGAVSHTGAWNNYYRDKFGGVFKPDLFISLGHQLRGDPQRSSCVVTPPIILEKPEGLADAHDLYDAVRALASVASQAGGPRFSLSVSMAGRWSKLLPTSKAEIFSACEKGSPRWRFFGRYTEVCKMPPYSTNLLYDVQRYAMRTFDPGTQRMFVYDDEKALCQKLCLAKANNTDVAFGVAVYDLDYEDTDDTCSDLNSMGAYSRFQAVSNVAKFLAHHFTDPSKLAACSSMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX88</accession>
    <name>A0A9D4PX88_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX88"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048441"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="409" mass="45785" checksum="9BA5FE692CB1C8F3" modified="2023-05-03" version="1">MDKVHDPYFYTKRDEFTSEVHKIESEISPRYSATEEAHKLGVCPLEPIKASPVVDGYRNKNEFTVGRHLETGEVVVGFRISSYRQGSMSVASAADLPNVPESAKKVAQCFQDYVQQSGKEPFNPETHEGYWRQLTVRTTSKDHIMAIAVIHPQALSEEHISQEKEKLRQFFTEGPGKSAGVTSFHFQRFDKKRSDEEQPDYEHVFGTEDIEENLLGLTFQVSPDAFFQVNTPAAEVLYRTAEHVAGLSTQTTLLDICCGTGTIGLSLASKVKRVYGVEVCRRAVQNAKRNAELNGIKNASFVQGKAEDVIQDVIRTVGDSEEIVAIVDPPRQGLHNKVLRTLRWTSSIKKLVYVSCNPEGALQNFLDLARAASNNYRGDPFVLTKAVPVDMFPHTPHCELVLLMERLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXR2</accession>
    <name>A0A9D4PXR2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXR2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7249" checksum="3DAB632D35AE167D" modified="2023-05-03" version="1">MCGGNDVLDAKAATAALTHIVKEKALPSKDMGIRDENIEEAAVSIPEVVIEELEALREPPRKPPNSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY20</accession>
    <name>A0A9D4PY20_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geminin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geminin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY20"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043856"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22589">
        <property type="entry name" value="geminin_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022786">
        <property type="entry name" value="Geminin/Multicilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372:SF5">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12699" checksum="1B325FD5D303BC07" modified="2023-05-03" version="1">MGVKRKALSEVQLSGKGLQVRKVSRPLCVSSSDAAPLGKEGGRKESIGQYWKELAEQRRVALEEALRENEQLHETVELLTAENKHLQSIADQALPLADLLKASSCLDSTKGRTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ03</accession>
    <name>A0A9D4PZ03_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin polyglutamylase TTLL4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ03"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031371"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59312" checksum="9FCAF3FBC2CA2743" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVNHFPGSFHLGRKDKLWQNVVRLGRIRGEKGRPSLPDTFLLPQELPLLRDAWSAETPGDHCWIIKPPASARGAGVHVVHRWDQIPKKQPLVVQRYVRTPYLINGTKFDLRLYALVTSFDPLKIYLFPDGLVRFASIKYSQECEDLSDRYMHLTNYSINKKSATYTAGGSGDCQGHKWSIKALQGYLEGLGVDFASLWEQMVDIVVKTLACAEGPMNRLIQRHTSSRYTCYELFGFDILLDEQLKPWLLEVNISPSLRSATPVDYTVKSEVVKDMLNLAGFQLPQQLKDDLDERLLECYGLEEQDDLSLNPLLHTYSLSPAELLKHRHYETSLMDVEEETSGLLESLTPDDVRVLVQSEDELSRCGSFKRVFPGGRHGDVTLLAHRRYYNLLLAAWERRYGHQRHKGLCALHIPVSLLTTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q000</accession>
    <name>A0A9D4Q000_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q000"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031342"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="470" mass="51156" checksum="EE530BC536852387" modified="2023-05-03" version="1">MCVGEVLHGTASVMDKIRFSINKYCSCDAASKEYAKVIVFSKRHSWHSHGGSYGELMLDDKTVLLPSSKATLKAITEALKQCNRGHWYPGPQAYADAAYAGPAGCPDPFDESCPHCASAVSEDSLATDLCTSEYASVVAIGLDYKKMAVYKNGRFTWKQAYLPDIQVNEETAFSTNLSVVIKDVQCGISQHHGMYAEADSLTDLCLTYTVKALYNVSHGSDPVADSYDLQLFLNKQCPCQQLKSQLPGYALLVVDKRSKLSDGVLQLGSGAKLYPLPYGTHVLPACSAQGDSINPRSDPGPETKLPLPELEISVEDGETDAEPCPENVQTTCPVCIDASEEPAATATQYCKSEYAAVVSIPDDAFTASTDDSDEKRQCRSGKLHVKQQITSDHEGEPTDAVKFTIMSSCRCAFLEQPTQFAVLASKLAPKSDEPLHLSEDVTLIGLPLGKTELPKCVRAQPTRKPFWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0A6</accession>
    <name>A0A9D4Q0A6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0A6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031283"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047844"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056983"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="45659" checksum="EAC5C98E6D78AFE0" modified="2023-05-03" version="1">MASDNLPTHLRSLEPLRKKQGYACQLDFAVSQRIEDYSGPAQPYSFSYDITNDFGTRLSQSESGDENNVKTGKYSYSEATGIFRNVNYVADKDGFHVTIDTNEPGTKSSAPADVVINSQVESPPQPYSFSYDTTDEFGTRMTREETSDENNHKVGSYSYTDANGLSRTVRYVADAEGFHVTIETNEPGTRTSNPADAQITSTAVEPPPQAAPVAVQALHGAPAAVAVHAGPTAVFLCCLLAVAASAPVEEYPPQPYSFSYDTTDEFGTRLTREESGDANNNKVGSYSYTDASGISRTVKYTADAEGFHVTVETNEPGTKTSNPADALYTSAAVEVAPAPAAPVVAKPVVAAVKPVVVQAAPAPVTVHAVQAVQPAQFAVHAVHPAQYAVHAVHPAQYAVHAAPVSYATAHHVTPLTLVHQAPFTIGKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0N3</accession>
    <name>A0A9D4Q0N3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_015428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0N3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031352"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="168"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39887" checksum="68941BA66180E216" modified="2023-05-03" version="1">MVVLTTFCLYAAKESAKRPRLRDVRRFMDRLRLNIHGGTGGTGYPRYGGIGGVGGSVYLKAIDKMELRDVVKDYPDKRIKAGHGQNSKSTQILGQPGTDITVKVPVGVSVYNGQNHLIGDLIKPNDKILVVRGGQGGNPSNQYHGQKGEVDNITLSLKLIADVGFVGPNIGIMEYADHRQISLADLPGLIEGAHRNFGLGHKFLKHVERTSMLLFIVDINGFRLNNASLHRSAYETVMSLNKELELYKEDLLSKPAILAVNKMDTEGAMDKYEELLEQLRKARQQVFFRMSSSLDEDIRPSVLMNFDEIIPIIARDAKNTLQVKQKIRTFIDLYVEQQRRAEEVSFKQKTEGHVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1B1</accession>
    <name>A0A9D4Q1B1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_017447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1B1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040125"/>
    <dbReference type="OMA" id="KSAQEMT"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7962690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22842" checksum="33363C499D3133C7" modified="2023-05-03" version="1">MSSERGDVGWSVNTNLKSSGDAPATARAPTPALPHKHLSSSSKEQDLDFQRAVMAWSSEQLNRAQPWKHFADTAKFSMPKSAQEMTNRIRSNADHFRTNYGIIFVVILVIYVMSSVQHLVSVAAVVAVGAALKLHQDDDSAAVWGTRLMIGKNQRLAGVSFVALLLLYTACFWSAIVWSVGLVVAIGIPDATLYAGQVSQKATRDSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q209</accession>
    <name>A0A9D4Q209_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Semaphorin-2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_019335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q209"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039372"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11238">
        <property type="entry name" value="Sema_2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000369">
        <property type="entry name" value="semaphorin-2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF90">
        <property type="entry name" value="SEMAPHORIN 2B, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sema" evidence="11">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7963034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="508" mass="57498" checksum="A86A24150276FED5" modified="2023-05-03" version="1">MGRPLPAYHTREFSCGRLYYRTFYMDRKREILFVGGMDKVFRLNLANINRTKCNDRSLSANKDVVSTCVYKGKREDYECRNHIKVIQPIGDGTKLYICGTNAQNPRDMEIYSSNLTEVSKSQLTLRDIGRGIGKCPFDPDDNSTAVWVEHGNPGDMPGLYSGTVAEFTKADTVIFRSALFNRTTHEQSEFFMRTLKYDSMWLDKPNFVGSFDIGDHVFFFFRESAVEYINCGKVIYSRVARVCKKDTGGKNILTHNWATFLKARLNCSLPGEYPFYFNEIQAVYKFPDDDSNVYAVFTTSLHGGPHGSAVCSFRLSDIQGAFGGKFKEQKTSSSAWLPVLTSQVPEPRPGRCVNSTKTLPDAVLNFLRTHTLMDSAVPQSGGRPVFYRENVVFLSLAVHKVDVDGVDYLVYFAGTRDGLVYKIVEWKDRSGQSFSNLVDVIEASPGEPVRTIDISSEHKSVYLGSDDGVRQVRLDLCRGRHLSCLRCVRDPYCGWDRDHHECRSYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3X8</accession>
    <name>A0A9D4Q3X8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3X8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12378" checksum="04158C9D475C3807" modified="2023-05-03" version="1">MASTWELLELAERMGLEGPEFRAWYEERMAREREERAAERKAKKKKLESELRAKMEQLEVERRALERRLEVAMDEKTHLESQSYGQVVDGCSDSSFPWSPDSARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4V8</accession>
    <name>A0A9D4Q4V8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_019583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4V8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031288"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="340" mass="35576" checksum="F540A481AD580A86" modified="2023-05-03" version="1">MLAKTYVRNLSPQAFSTACRHNSTLVIADHSGGQMLPSTLNAIAAAKKIGGEVACLVIGKDVSGVRMSQVGKAEGLQKLLLADNAAFDGLLPERLTPVVLATCKQFNFTHLIGASTAFSKGLLPRVASKLDVSPVSDVLDIKSPDTFVRSIYAGNAIQTIKAKDPVKVLLVRGTCFDAVGVGSSGVSPENAPTAEFDTSKSSFEGQELSKSERPELTSAKKVISGGRGMKSGDNFKMLYDLADKIGAAVGASRAAVDAGFVPNDLQVGQTGKIVAPELYVAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADLGLVADLFKAIPEMLSKIDNYVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5D5</accession>
    <name>A0A9D4Q5D5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055165"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1742"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1868"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1917" mass="211727" checksum="DFC3F892C5C0E840" modified="2023-05-03" version="1">MELRKAEHQNTKTYYFAAENNASMCQWMNAMSLAALMQKDTDRSRQALPLHGMQAAANASQGIPPDYHFSPHVAPQRPGMQQPQRPSDESFEVEAYSAGAAPDGHYLGSGDQYPCSYTRSPIYDQRPPPAAPRQRPCYPVYANAPPKPLRHGATSPNVAEGGGYDACNSYEGYDFYGAQEPLPAYAGRPVSAHYGDNVPNSTMMSTQLMRPRSADFLERDDDGEDRELYFRKKSAPAVAAKPRPKSSMAHYDWEDEDEARDWRGQQQQHQQWRSRTMETVPQAGAFHDESQLGRMPSVKALSASGNSTQSKKAAHKEQSMKRLLEWKQRMLQSPLCKKPELQSAVLRKTPMPESALPPERPPLPEEYRRRASEGSRPMDGMLGAHFFNTEPRGEPVGRAQESSAPLGPDLIRSSLPRHQNDESAFLEEKSLLQGRPLTSPHGSTVIRDPKSVLRHHNSRLSSDDRVTDRDTSLSRSDQGLSSPRPNVPQERLYGNADMWLRKDSPSSSHPSQRPKNTPQDEEAFYIKKEDYYRASQMFYPKQPASKTLLGSVSDIESSGSGAAEMETFDSRYRRSSTTPKSPQWEIDKDVGLPVPDNLDVSFQSTSNNSVFEASCECQTPGDQSPELFQGTLRPNRTYVRDRQPSKSPMHLSKDVGIDTEVKCVEATEVKIPVGNSSFEEMRAAYQKKKEAPPVNIVQDRIKCFEPKDETSPKHGDSVQESWEAAEENRIGDRTASSAAGNNVTPQDVEFRTSASDAAKIDSLSKYGSTSILASLHRSAELNRESAQHAHGDKLRQGEVPKPDTMPLLRHCPQEPPPCSVQSKPPEAHYLPMGWLTSEADYVSMNVDLSPGCPYEEPVYNEPVLPVTSYAHDSYGKSSLACQILKSESSGSSSGGSAENIYEQVQQTSEDLHSMPYSSTGNNVQSKRESPPVYEEPYRLAPSQPETKSPEKPKSHELYMKDGYKHLVKKAIPDLLHHEEVKDSGASDADDEASRADFDTATSSLPSYQKEILNDHVSSPLRSLAQPYLPVYTSHATKYSFKKERKPDAATSSAQSTDAFKEPDKRSPSQHSKFVSFAGTAPLTNSKMSPDAFVKVSSYQSENRPTSIGLLKSLDGETSSSEAGSSLTSSVVKTSSVDTSLRSSSNQGNFSQVSSPLLSTAPDVLPSEVRCVVSESNSNKVLNSSSTGNSAPYYYSDIFGDKLGSAFGSSAARPASQQSRATPNMLNNTRDVTSMSPHSKDHVGRKVNKISTPQAGLGVSHTRTLSEPQSTADLESTLRGLLHPANTRKFSDAERNKYVAGHTLEKTSHMSRSVLCHMRSKQAAEASQPRSKDCVPSGCGDSEEGTASRSPGKMLPRRLSRSLEDIIDSSPAEHVTRSKTPLIPSSCQDEPYYENVGFGSARTQPSPSKAVSGASPQVSPAKHSIYDGEDLCREFVATSMLNDPLGILGKSAEQLPAERPQKTAACSGDFVQMGSLSASLGSLKLSSPERQEVPFYSSHSPLVETGKRCWSNDFQKSAAQSDLHRHSIDNLHGHGMEVQPKNSPERASQPTSPSSPSLSHSISAGDLLGKSHEELVLLLIQLRRSQSNLLSCQLQCKEELHELKQKLVQSGTQSSAADVQRLVGLQRSLNELTRNLDLTQPLISLVENMVKLGSLYTVAGISKQNKKMDEGEDYRYEDTYADTLEAETLEKQQLLIEKEILHIQNMLAESTSCGSPLKDDLEVELKRLQKIVNDLLQKRSKVSMPPNTYVEKEPQVKAKPPEPRHSPTAGVPERKRHQKTYYETDLDSSVTSNLALDSRPTSLCDIVTTSQIAELESPSFSPEPSEVPDDRSYVVQDISKADDRTKKFYGLLPRDRAQEIKTVRIVKRESERRNKGKDRRKGGLDDNCPWLAEEGDSVFQNEEEEDDSAFPSLLFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5F8</accession>
    <name>A0A9D4Q5F8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5F8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034988"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16687" checksum="67ACF73DDEEBC78F" modified="2023-05-03" version="1">MNTRYSRRWTYAANYLPSPRTCVSLLNVNDTELYCFGGIFYNCVGPTRKLLTIDDILVYSDNKKVWRQVACMPAPRHNAHVLHYKNQAYIIGGQDVEKPDHPLTSVIKTPVPTEKFSWGPLKDVPLPISAYAAVVLPPIEEPPESKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5H0</accession>
    <name>A0A9D4Q5H0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5H0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047420"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35166" checksum="38465AB48CE06F15" modified="2023-05-03" version="1">MAEDLEQPQSTEMAIADPQRLDVGRIRWLSRAMDELLVNPYDDMRRSLQNIRECLHESRNIARVLVACIANVQQYIDVVDYAKDFERMGGFQVFPDLLDYPSSLVRVETCALIAELVQNNPHCQRAAFLSARRLMRLLDSETDDEVRCKALYALSCMVRQNRDAYANFEKLGGPTVLRRTLFETPNRRLKTKASFLVATLCAQEESFRHTLATSEFARDTVDLLPHVDGDCRQFLLSALLSLATHSAQPLLSERPAVKEALVAMLAGFIREHRDVAQFQEEVQYSTEILELMKDRRELPRMISLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q697</accession>
    <name>A0A9D4Q697_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_007975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q697"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7968363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="372" mass="39984" checksum="EB1E2749635FE875" modified="2023-05-03" version="1">MSDVSDSSDRSDVDDASDVSDGSDSSDDEPKQPSSDPQIGAGCAPADIPFETILTDVSCHPTRDAVAIGTVDGDAFVHSYSLDGPSRELLHLTHHRSSCRKLRFSADGSILFTGSKDQSLCMVDLNSGALAQRLSEAHSASIYSLCVVDEHLLASGDDDGCVKVWDRRTNAAVMECRESDDFISDLATGDNHRVLLATSGDGTLTAFNLRQRALQLQSEPLEDEFLSLALLKAIFSGGDAFFFFQHGRKVLVGAGDGSVNLFSWGRWDNMDDRLPLGRSQAVDSLAAITEDLYCLGTADGRVRVASVLPNKCLGVLGSHGHFPVESLSVSRDSHLVASCSHDQRVKFWDVSSVENLRPPSEDFFAGLEAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6X0</accession>
    <name>A0A9D4Q6X0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6X0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="83207" checksum="8EE35542041E6E1F" modified="2023-05-03" version="1">MADHFDEDCQEVPPDEDECDEAAQNEEPFQESSEEITSLTSFHRDTRRTARAWRIFGVILSRSGTRFAALATAVARGLSYQQLAELLADTMCTGAAEASTGIPQLPHHRRELMTPRCFLHTEGIQREGAGSLFAPQAAGGACSPGGKRGDWRSSRYSDLKAHANTKKHRELAGSSSIQKQLGFTTKRQVQPGNAAEGRTALFIAEHSSIMTADHLSQLYKKSFPDSEAARAYQMRRSKCASVIKNVLGPHFKADLAQDIGDSYYSLIIDESTDISVTKFLAISIIYHSVTKSRIMTTFLNLCTLEVRTAGGIVAAVKSTLMEYCLKLERMRGVGTDNASVMTGINNRVHRKLKAEAPHLVLIRCVCHSLQLATSAATAEALPRILQYLISETYNWFARSPARQMAYKKLYGLMNDGDEPQKIVQACRTRWLSLEIAVSRIVDQPILTDVQKVNKAFEAKDADQTKLLKDLRTLLSSLVEKVVIPTEQIDVLTCRLEDHLNPKPYLGYLFETYVDNMKAQKTDEFSVADEAVMRESCIRFITTLVDEIRQRLPDNITVLQKASLLSVENALYVVKEPLIPLLDAMAVPPETKEKIQNQWRKITLLDWKQISSTQSFWCEVHSYKDACGENPFAEQAGFAMSMLVLPYSNAEVERTFSQLNIVKSKLRNKLKLETTNAILVVRAGLKRHQKSCFDYELPAAVVSAIGTSATYVQPSHLSGPSKSTSGPVEMVSNDNSGDEDLDVFFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8B2</accession>
    <name>A0A9D4Q8B2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_024162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8B2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.70:FF:000001">
        <property type="entry name" value="DNA-binding protein SATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.70">
        <property type="entry name" value="SATB, CULT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032355">
        <property type="entry name" value="CUTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038216">
        <property type="entry name" value="SATB_CUTL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16557">
        <property type="entry name" value="CUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51983">
        <property type="entry name" value="CUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUTL" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7970115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="300" mass="32983" checksum="AF26E150DFEC5985" modified="2023-05-03" version="1">MDSVKTAVIQLLREMSQSKLAKICPLKQSLLSTIVNNKFTGKLGAEKCKEFGTWFMQYRQSSPATAMTFLDEDKPPQDGRMTFHSTTELPRMRDWFRQCPHPTNLQLQDFANQLNCESLRLRNKPKVTVNCLKNWWKNERQRERRTTKRRSPGGVDEDSNPGSSAGSSSAQCPVPIKIAAAVTTASATATPCIIHHHRSPPSPPAHSPSPQPSQPQATRPLAPSFSSSPHNRPQHPVVTLATHDYGARAAAAMMPLRHLHHLHHHHHHPRFVPASSGGVVPAASSSPGDLVVALSTTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9U2</accession>
    <name>A0A9D4Q9U2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9U2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046062"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21163" checksum="38DB82D3D41C3AEE" modified="2023-05-03" version="1">MEPPLSVVLRFGFRAISGVAEFFRPSNLRKGKKLVNVNMPFDITDDPLTDDGLEVDKPHCITVPERDFVHLSDGSFHLAKGVVITASQAAKVLKNKKAAIDCKDTAQAIWGTELLSERSVYGVAAPKARATGQLPKQLLTPTKADVVTATVRHWGTIKGEDVSAAIANITKVLSEKIQDARKSTKRLAAMSKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9Z4</accession>
    <name>A0A9D4Q9Z4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9Z4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039789"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08389">
        <property type="entry name" value="C2A_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08408">
        <property type="entry name" value="C2B_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="206"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="487" mass="53445" checksum="2419D81C330DD520" modified="2023-05-03" version="1">MRLGCGSLDAELAVPVETTVYLGAVGVILVMLGVFYLYLSKKVCFTTIGGFPCCDGAVSSRERERQVIARNLGAAYAYDDVESSSESDEEVIQQLHHSASLQGGFLNSTSARKVSSMGHSTDHAHGNGHLPQPDLVSLAENGRAVSTGAEAAEAADTSRASSKPVQGTSTVRTALQYENGAFLKAEDSPLSLAACGGTDVRSQIIVLSVRNFSTAVLQEPMLLDLAEEELRAHDLPSRDRGGANSVQVRLLLLPHKRQKFRTKIKQAGEDMTFNETFAFTRISPEEVNTMGLRVRLYGCERMRREHLVGETVLPFQCLALDQPSTMWLMLEPRSNLAHWDSKCEISSLARSDSTSSAQSMQHGGLPELLLGLAYNGTTGRLAVEVIKGSHFRNVTMNRAPDTFVKLTLMSSSGQEITRSKTSVALFQLPDVTLMVSVYYKRSMKRKDMIGWFSLGLNSSGEEELSHWNDMRESKGEQMCRWHVLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC66</accession>
    <name>A0A9D4QC66_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC66"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029187"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="633"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7973190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111504" checksum="30850E6F24B0DA44" modified="2023-05-03" version="1">MGRKADRKAGSGSSSQEWVFCVSCEVWVDLECTPFETVEEARAAPAFTCRQCEKIDTVKAEMAALVKQQADDSKLLIANLEARFEREINAYRSECEALRVTLQKEREDKEGSTTECEALRQALQQEEKLREILRDEIAALRLAFEEMTACRPAAAPSGTAEAPRGDGTASHEDGAANASSSGGTVKAAGEPEKTPPTHRGGTGNVRTKPKTRAKRRPGTNCAQAQTAKSDVVRGGHEETSLQGREEQDLAGPKDQVTPGAALKRHLEKLGASAQQDRRAFVYGDGNAARLKRAALKAVGWNKRVMFRVKEGASLQELCSSVDLAEDIWQTPAAIVVLHAGSLEMSDGSSAPESSASQLRALLTKWLQKAQGHRFVVYALTERGSGSETHINPCREWNVAVRKMCEELGPRVEFVGASWRLGHGQQGPSYRDDTADQLGQRLGRRLCAFLGLRMPTRHWGPPSQSHPAAGTLMTALGQAIIQMAEGQHPHENGRRRSQGGPHRHTRKRRRCRRKGKQDMVFYLNLQGGRKEAKWEELFLLLQKENVTVACLTETHLRDEETPPPNRQFVWSGLNRTKGERKGGGLGFLTKVDTQWDRVQRDCKEHMWLTGEIGGIEIALGLVYLWTGREVHQRNTETLACLEKDITQMNRPVVVVGDFNAHIEALDGTTDRAGRLLLEWTERLGLTLLNATEKCMGRITWAVRGMSSCIDYCFLSPVLLPKLSYMSIDSTGERSLGSDHHSIFLSFGTNPPETKRDAHAGNLRPLSDEALERVVDQLEEDAPRMEGQGYEELQQWIRRTIQDEAGAGRVTRGRHRRKAWWDGEVAEALAQRKQCCRRHRHALGRGADEAELSALWSLYLEAKKEMASMVQRKMSTVNRKLLRAIKEAGRDSSKKFWQHIKAQQTNSDLPSHQLRDPESGRVMEGEECLHLIRRGMASKLQSTDSGTSAQGATGATNDSSALARALGFRGSGEPPSWEAVEATKRRLECWWRKQVEQTRAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCX7</accession>
    <name>A0A9D4QCX7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCX7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048702"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="565"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7975487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="702" mass="78691" checksum="EBEFA09701710DB2" modified="2023-05-03" version="1">MQNRPYLGGEPVLDQPLVRASAACLAKPNAERKPIGGRAVSARRVLATLERSSPKMSQAAEKTIETPSDQLGDADTVHMDATEIRNAEATWRYDASSGRTIERESVWITRGRKGKKDAGETTTPEGKPHKEETSTQQPQPQRRKPMLPPLPFDDYKVVYRPQAGLELAKWNNIAIMHAIGRASGLSQQDFGEKVCVQVQRLENLIIASTAEWEDAKKLESITSIQLGGTFFTIKGNTRTPDDVSRGVISGLLPGTSEEELKSGLHAQARYTILHARMLGQSSAAVIFFQGPHVPYYVRFHSLDFRCRPYRKSVQYCKTCGNTGHRQDVCPRPQPDFCSKCGKTNQPSDHVCIPTCKLCGEGHETASKDCKKRLKPNPPPFHIRLQRMERLKARDCRKSPGDEDFPELGSQTTNLRSSAGSTTTRVTFILTGSGHEQMAEVPLAQFHLPASARGDQNRLKMAVPNHRTTNTLSTLRIWQWNCRSYRPRYASLQEFVKQDPPDLIALQETNTENVRLLGYNAHVQTKRTAILTKKNLTVQELEPVNTPIEHTVIEVIPERKSHKSLIVASVYSPPKDQLPDFDLLVRELKKRADGHQVVIMGDFNAPHTAWGYHTTTKKGARVHDTAQQHRLTLWNDPLQTTRVGNSVSRDTNPDLTFTLNVRSAEWDRLPETLGSDHHIIQLTVAHTRKPARIGTAQITEEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDV1</accession>
    <name>A0A9D4QDV1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDV1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="25925" checksum="DED0BBE16146D11C" modified="2023-05-03" version="1">MSVSENDSEGTVARSESYCGVPPETSASRCSAGDQVGRSSEQPRRADFACQEVVQCADKTVQCTLDTCARFDDLYREHELRMEQLRKIASYMRQNKTLRELCLRNSCGGDEGAAVLIEALVENDTLKIFALNDINSSSDTLVCFAKMLSINRTLEMVHLNERLQVVWPDELLSVLTALIRREACSPTLSLRVTSSIDEGVLREFFEAVAENKTLPFVDYTSIATYSTLSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH30</accession>
    <name>A0A9D4QH30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036916"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14397" checksum="D52E28ADB08FBB3C" modified="2023-05-03" version="1">MRRRRMFCGYEILPVLGRTRTDCKLNPALVTAVPTRAVSLTSGHAVSVERLRAVDPKALAFVSVDYAVLIAKKENFKSSLLKFVDTYSNEFWRDRFQGFEIRGVPLADYLDDVKMAALNTIVNVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH39</accession>
    <name>A0A9D4QH39_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH39"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048744"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16693" checksum="111A955C64D26C4B" modified="2023-05-03" version="1">MPDDGDGLVPDQRPPLGEADSLNTENEELGRWSHFSLAMLAAEQEAASAEQRGEDCDDDDDPSARRHELEEPDPVTKLERYAYSDIVFNRATPGLLSAARDRAWDRHDERTDTHVGRVAPGSVFGYRLQRWPRSRVARDAPARGSTGHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SMF4</accession>
    <name>A0A9D4SMF4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_025577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002195">
        <property type="protein sequence ID" value="KAH7931568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SMF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034547"/>
    <dbReference type="OMA" id="FAFCFET"/>
    <dbReference type="OrthoDB" id="6506169at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7931568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18686" checksum="8F04867B0969C118" modified="2023-05-03" version="1">MTRSDLSKDSSEDTNDPGFYARNNGDQRLLNLKALDMVEKDLDHMYDRNLQFLDLGCGTGDFTRRCLLPRCPPSARNVAVDSSEEMLSYARQMFAHPRIEYDRLDISGDVADFVAKYSTFNRIYSFFCFNWVRNQEEAMKNVSSLLSSGERVCSSSGLVSFKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPW9</accession>
    <name>A0A9D4SPW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPW9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7942730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="19111" checksum="C163D8C8572157F6" modified="2023-05-03" version="1">MCAAVDATVYDVPLSGAPEQPTDNLHRRSGLQNAFIQPPTMVSSWDDHRYTVPRGRFGDVREAPVCFYCGFRGHVARFCAQRRRAPQRHYEGPPPSPRQNSWRGGMRSMRDTYVGNGFQQNARSDTHGVSASERQTANPDSTIHQWEASLSSIYYRDQIGLVARASKAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRG9</accession>
    <name>A0A9D4SRG9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRG9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030145"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25934" checksum="CA3D16F53A1ECA9E" modified="2023-05-03" version="1">MSTFKSVSHVLFDLDGLLLDTEKLYSRAAEMLASSYGKQFTWELDRRVLGTPDFDAARTIVESLGLPITPSECMEKLNQICGEYYHDCDLMPGAERLLRHLKAHGVPMAVATSTTPALFDLKMSRHRDLVPLFHHVVCTGGGTKVKRGKPHPDIFLLAASMFDEKPPSEKVLVFEDAPMGVTAALAAGMQVVMVPDPRVDEENRRRATVCLGSLLEFKPQMFGLPPFDETSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRX4</accession>
    <name>A0A9D4SRX4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032602"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045887"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052894"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7946786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1028" mass="110548" checksum="4B36B20886325C6F" modified="2023-05-03" version="1">MDLSSSRKRPRSDSSDDEEEGPRKVGHSAPSEHDSRDSERSQDSPALQPLEDSEDSSDTSGSSSIESPSPEETTSSSASTAEELTNDSCPEPHSEVTHTLEAAPPAAAPSPAAVPAAEEVHENEGDTMEVTAQEQEEVISPPHPSEAFLRSPPCPTTSVNPRRKKNRKQKGKKKMPAQKQHPAGASQGPASRPSQPFCEAPTAVINAAAHSSTAGTAPDTEGFQVVTTKGARRRARDLAAAAALPVDPAIVGTVLFRPSAPGGSFSGSPRLILAQALSTRPGVAAIRVNQKRNIVAADATSRECLEQLLTIKELKGIPVTAKEPADHKTSTGFLHGVDGEPTVDNLLQGIKSAVPVLSTAREGRTVTLRFAGPVPPEHVSLFLVRFPVRPARPRPMQCRQCGRFGHVKESCSWPGSCIRCGRTHQGENCPQPHPRCVNCGGPHPADTPECPRWQEQRRVATIMASTTSTLSRRAVTAAVREEIQEARTFASVVKGHPKPPPPPVRPTPAPRKSRRQAPGSSGTANAVPETPPAAIAVPEVPPAATTTTMAQPAAPVPAGLPAAPTVPVTPPAAIMVPPAADPAYQIVTTLLLTLLSRELLQAEVPVDDLVGGPFECCAVRIRLEGSDTTVASVYVRPCQPWDPRCLLQLANRLGREFLLCGDINAKHPAWGGCRTDARGREVRDVLQQLGLVILNTGANTFIRRGGKATSTAIDLSVATEGCRYAWLPLPDTWGSDHLPILLSPFRGKAPRVREYRVVDWRVFRRLLGQDTGGRDLMQLVADSARAATVVTKAQQGQPVPDIQHLALRAARRRAERQALNKALPELWTVFRRVDAVCRRHARRRRNQGWLGVCISIDRTRDGTKAWRLLRCLLTVPRAFNQVLSLAVHLSIGAAELAEQLADQFAARDVAQLPAAPPPAALPCPSSCPHPGWVSVQVRELCAQPIGMHELGRCTSPACNRCGDPETLEHLLCACPGLAQERSRVTTAYRRLGLPASTLEHFLYPSRPHLPALRNLAEFLEETGIAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS24</accession>
    <name>A0A9D4SS24_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_009631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS24"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055769"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058115"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08576">
        <property type="entry name" value="GDPD_like_SMaseD_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="685" mass="77199" checksum="B3690603854E1097" modified="2023-05-03" version="1">MIWSHRSASSIPRGFFSDLTSRGMAQRAHGRAFHFSLSGCLDSGNLADVEIVVDCSHFPGTKATFKAHKMILAVQNDVFRAMFYGDFAKEDRIVITDLHPEGVHGLLRYFYSGHLEVQTVHQAACTRTAAAKYLIPELVDKCLKFINCRMTPDQVCPFLDYVLTVGEEALATPATIVIVKESSKVLSSSTFKSFTEATVKYLLLHVTNISELLVLQAVCAWGQQRLTLVEEKCTSKRLRLRDHNFEQTISHEERNGGPPPCHLRAHPSNTTWKLRGEETRAFSRGVTRCNRGSKYSTCSRCVTPPEQLNTEGPHTGRDVLRLRAVKQALPSPANVASPTTRGWRHAHRGHENQDGSKLKMPSSRNVSQFVAVAAVICIVHGQSLSTSAIPRDLARRPVYNIAHMVNTVEQVDEAMRLGANSIEADVTFTANGTATWFYHGVPCDCFRWCDSHEEIPALLDYVRRTASVDGAIYKERLALLFLDLKVTNVLPQYKYRAGVDIAEKLTRHLWSGVYTWNAMNVLLSVRSVRDGEVLRGALHTIYRIMPLMLSKIGVDVSNSDQPLDAIRDLYLRLGITGHRWQGDGATNCVSYLRPPQRLYNIIKNRQSEVPHHYVEKAYQWTLDTPGELRRSLRRGVDAIITNRPDRLAVILREDEFRDVVRPAIVYDNPWTRFDDFVGMDSGMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS93</accession>
    <name>A0A9D4SS93_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS93"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10058" checksum="AE246400AC06EF38" modified="2023-05-03" version="1">MWAALGASLVSLFQHLPYQLYGLAVDVLPASPRNSPVSRTLSQEAVVTVGNAGPELRQPALLRRRLPGKSETGGPPEERETGPVAANTEVLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSD8</accession>
    <name>A0A9D4SSD8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSD8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043382"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="448" mass="47962" checksum="8BE91A2CB1AF3F1B" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFWQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSNPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGAQPSHDHDLPSPAMTPPTSRPATSASIPAPDHPPDEVQEAPAAIGRSTEKSVFSTASAHGPSDVPAICTSSSISMAHDTSATSGSTTATSPHALEPAIDTDIVTPAVRPPIAEASSAMSNEPAFSTSTLCVSCQQELPSSSKSPAAEVRAPNHQRPNLRDAATMTEASEDDLLGSTLAEQAAHVTPSTSAGIQLPDLRTSPRVPPAEGASTRTGAVPEPAATTPARCHRRFAPKPLTQEAAHPTCGHCAGALCRPPLHVYSHRTRRYFVSRRGQRARSVPSSHRHCCGLCNTSSHAKPTFWDRFRHAERRTPLLLPTASIRRDPRPLRSSQSRPPETHWSPMVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSK6</accession>
    <name>A0A9D4SSK6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_013124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSK6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054887"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039065392" evidence="5">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7943916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17808" checksum="BD3FA496DE3F8F88" modified="2023-05-03" version="1">MACSAVTLSISTITAVLALACLSISFGTDNWLETRVNRTAIRQTLQKDTDEYRAYETRMEYFSRDTGLFRICFPEKKPKGLETFMSPVQTDCVNVNYYIPENEESDGFSEQRWERLRHANDVRTTAWLIVGRGGAQCENGGSSLKGQRGETFSIQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSN3</accession>
    <name>A0A9D4SSN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_011336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029255"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="316"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7943763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="842" mass="93056" checksum="25EABDE3B3820323" modified="2023-05-03" version="1">MPRVESAEGIAAKSESPAVYAASSGSSPTRLSRHRQPSEAVVPQTASTVSRNGHSASRRRLRTPGLKATKSPSNATPPADPAVRRSRSIAGPASSASAVRRQPRAEHGWAPATTTSSRYTPRIILPYRHRGGGSGAKRTKSPMKPAAKASGAAARSPYEPPRTPVSFDDSEKKTQEEDKAKDAVDSSPPSRLQGTRGSLPSLAKSSPYGSSLNVAHRRASSGQTMLSDEVLERMHSLAIEGAHQEKANGRWLEAPWKALVACGVAAVVLFAVLAVLLLSHRPLTAERPRNDSPCNNAGCQRLVSEVIDRLNTSVDPCDDIEAHVCGAIKWDDGLVTDTASKMMRMWMRRGALYLQSKSRREAPFSLYSACMAPAAECVSQLKAFMRGRGLSWPVYGADNSQHALYVMLDLLINWGVPFWFELSLRRLPNDTRYSLYVNRVPMNKWRRQQQVSDDLGHLKEYAKMFYDVYGASKADRSHINHLLKLEKDMHAIIEPPDFQDRIKPGALTEIRVPVRWTTSSTSSYGSATWLGFLNELLRPHQFTLEDYILVDDVGLSRAMDEFLAKFSNKDMLYTLGWWFAQQFSVMASLDGSVASYGSAATAAANRQSDCYALAESRFRRQLFLQRAQASLGHPGMRQVEGILNNIRSTTMTLLSSLPWMDEAARAEAVAIVEATEFEAWKRRLGNDTEEDDRTTPIVGSGASKAPPDNFSVANGTWVAIGNRTSDARPRELTAKPLLRAAVRRQGPASTSNVTVVQAWIEAAISYKRRFPNWPLDDTLLHRHLSYATLAHYDYWWNSLFVQMGALAEPLFYLDGPVSANYGGIGVLVARHLFKAYDYMVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSW0</accession>
    <name>A0A9D4SSW0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050320"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="288" mass="31996" checksum="392E0E145BAF27D0" modified="2023-05-03" version="1">MLRFHWDSSTRGNTRLLRLALNKAIAQYAQPMHRATLPSLAAYERQEWHAVANVLHDLHGLPRPPPNPDVEEVGTVPVFEEFFSKEVLDVPEGFQSNDSSLVLPLLPPNETTVPTFGKLSDRFVNGNLTESLSALQDDNSFPELSAALDANSIEDIRCTECTSRSLLELSSIAARASQESCFRCSELRATRKNFEVLQARFVSYFFWPALLDTVNVAEMVELPSGTYEKGPKKYRKRSRIKRPWVKEMWKERKRLASAAAVAGAAAEGIDAPQEDCDGGPSGTSAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUS8</accession>
    <name>A0A9D4SUS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053473"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10235" checksum="54981DB46344673D" modified="2023-05-03" version="1">MVWKDDAWEARFTLRPVGLVLSSLRSDQHGVYMCRVDFRQAQTLNRLVRLTVIVPPRAVVIRDSRGRPLNGSVTAIDGQSLSLLCTAPGGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVB8</accession>
    <name>A0A9D4SVB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026960"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="461" mass="51589" checksum="11C5D7289E42AB52" modified="2023-05-03" version="1">MSAKAGSEFAPSPPSSSHTVGELDRAFTVSRDAPTFPSMHNARLQQVPARATCQGVKEARAVNKAVKRCRSSGRFCIFSGCMQVQTVRELICKQCQRRITIQRCRCIDVSGQVLEKAQEDRRGKPSRPLVVVAKVVYESCPQTSDDGTREFRKNDVEVSASAYQNKAQTWSAGRLALGGSCAGEGNRTLAHDTDRRRMCTAATCKDLLEPELLRSPCHSLFPLQRQLWQRGVQELKTIFAALPKKRQTLLFSATITATLEELRSVAMTDPFFYTAPADVMPQRERLASLNMFKSNTTRVLVATDVASRGLDIPSVELVLNHNVPSAPKDYVHRVGRTARAGRGGKAITLVTQHDVHLVEAIEALIKTKLALQPTKESEVLKILTQVSVALREAEIRLDEQDFEERKLINWRKKLILQGLDPDEVEAKKRKKQQQRLLQRKRKGRRLAEGKGAQRQEESLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVP1</accession>
    <name>A0A9D4SVP1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_004615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVP1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047227"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7951066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="401" mass="44110" checksum="D0C6E90F65D2FE4D" modified="2023-05-03" version="1">MSRNRKPLTLREKLRIIEEAEKRNGATKASIARDLNIPELSLKTILTKKDSILLNAAKIGLNRKAANDGKYAAMEKALVEWLRQARSSGIAVDGAILKEKAETVALRCGIGDFKASNGWLDRFKKRSGVVYSRCCGESAQLQPLDAGVIKCMKQKYRKFLVQRRLAGMERKQLDKKLSVLDAMHYIASAWDAVTPETITDSFRHCGFNRSGACSTSEAAVPVDDEREFGSLELPGSFADYVGANDDVAVCSEVLLDDIIETVRPDTAGTSDEEEMDDAAEASACPLTLRRMEVEVEGEEVTREELTVERGWHTARSRRRDGRGGKNSSPSASPQTQESCSRTIPKKNVKAQVLKAGRVPPLPKNEIKIILRPKGGLHICKVGSPTVTAAIFHTTKMPLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX59</accession>
    <name>A0A9D4SX59_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_000874</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040884"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7955430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="34529" checksum="634414D0DF88EEC3" modified="2023-05-03" version="1">MSLLTLQIGQCGNQLGFEFFNVLAQDIGVGEPETRRDNEYHSESADRFFAVDPQGGLLASAVLVDTERKAVGRVLKDACNSDKWHYTSGAAYTSAQGAGNNWALGYFEHAEKGMDEICNLVRSHAERQDWLEGFLPIFSLGGGTGSGLGTKLTEALRDDYPNTPVVTAVVWPFNSGEVAVQAYNVLLSLARLQDSADALLVLSNDSLHRVVTQRWALRSASLVEMNALAARHLACLLQPSRATYGPSKCLGNDLGCFGSLKQVSLLQVPQEPPAMAAFSCSSWQGLVRALGKMQRCHSATDEESALERKRTLVSYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXR2</accession>
    <name>A0A9D4SXR2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXR2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048389"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="21388" checksum="668A5A0515157E17" modified="2023-05-03" version="1">MFRRYQTKQDSHSESQPYHQTNNRLALHSNLSETLDGSLVQCALVNATIAGIGQVDAFPDSGSKVTLVSRHLVGSLPLLPWTRPPLAVVGGTTVAPADAICLKISVGPSTGLVEAAALDNNAVPLILGEDWFAASHAQLVFQPPMPSEIRHSTTGTSVRCHERLLPRMSNAVMIQGSSFNCHASTPQLSRPPANATPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZS2</accession>
    <name>A0A9D4SZS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_019354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050866"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000003">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="115"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7963045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49872" checksum="92063B76FE3F7CA4" modified="2023-05-03" version="1">MFVLLCDAQFFIAANTDVPVESLWQDKYYLRKSMMPSFLSEEQARKILCTGKAVNFLHHVCQNTPQQADLPPPNSVECLLNEQQDDSFMEYLEQTYHTRNCHVLSVLNTQFKFKEHLQALRQFLLLGQGDFVRHLMDVLDKQLSQPAQLLREHLLKAALDEAVQTTNAQFVDPDMLKRLEIKLLDINPGDTGWDVFSLFYRVDGPIGMVFTPYCMSLYLRLFNHMWRTKHMEYVATAAWMQQTINLKVKNCQRPTESQCTLHQCHILLSEMIHFMQQVQYYMVFEVIECAWAELESRVEQAQDLDQVIHAHDDFLAALMTRALLEPESRDILSQLRSIFDQVLRFKEVQGELLSQLNSGASSLRAQASLRMISESYQDFLLSLSRHDDTNLQGLGFRLDFSEFYNRQNVQLRTSMTFHSRRQYQGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T028</accession>
    <name>A0A9D4T028_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">XPA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_012144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T028"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040041"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="11">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7961783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24850" checksum="C649ADAB3A63E4AA" modified="2023-05-03" version="1">MATASGDTTVPELTEEQKKAIAEKRERAIQIRKAKLALRSITESAGGSPTKQQRVVDTGGGFLLDDGTPSSQTVPTPTTVEMPLEHTTCDSCGKQFLMSFLLEKFALEICDKCRDKEDKHKLVTRTDCKNEYLLKDCDLDMREPPLKYILKPNPHHAHGNMKLYLKCQVEERAIVVWGSLEALDEQLEKRDEERSKRKRKAFNKRVKGMKHPSVLQNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T098</accession>
    <name>A0A9D4T098_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T098"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="14804" checksum="B142250C0DEF4F32" modified="2023-05-03" version="1">MLVSEVTLPPHLCGETRSREDGPTAQAEKEPGAVVHELASQTEDGRTSTPTEASNPMEWSEHLPVKNESTNIGVPGKTPHEQSAGGSEASSGKHLDWPPTKASSFRRSSIRLRPNPTVQKHKTPPPSSGTGPPRGSEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0T0</accession>
    <name>A0A9D4T0T0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0T0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049339"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47228" checksum="D68706A7FE6D5CCB" modified="2023-05-03" version="1">MVPKPESFVNQATRPRKNFNSNEDGSDLGQTSDPTSFAHASPQFSAPALRVLHERLKNCNDELRLLNEQLEEHLTDEEAAEDYLSVSGYEGNAAATLSPLTYHIEKLQPEATADRGLTIPNGVATPGATSGGRSIGEASRPVAASFLLHFMVPKPESFVNQATRPRKNFNSNEDGSDLGQTSDPTSFAHASPQFSAPALRVLHERLKNCNDELRLLNEQLEEHLTDEEAAEDYLSVSGYEGNAAATLSPLTYHIEKLQPEATADRGLTIPNGVATPGATSGGRSIGEASRPVADSDQGDPNDIVVEHYKRQSSLQMPNETQSSVTELQQLLDHLRLEVEAREKSGQQETCVHDTSEGRRDRRPSATPTASVLHSASNKTTESNVSEALQQFCDLDSIGISDPSSNEDQENEVATSTVFTLRDNHNGSVCANEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4P3</accession>
    <name>A0A9D4T4P3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4P3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12321" checksum="491458C27AE6DCA9" modified="2023-05-03" version="1">MQYAVEGEALDPTELKESTWVTPKTTQGGLDPLDLQHKYRTTASKPLEAMPEKASTPALDVQAARPPQLPRRRPMPRLSSEHYKIVIRPRHPINLSNNGLATLLDAIQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T609</accession>
    <name>A0A9D4T609_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_018517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T609"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029195"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035157"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054291"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055268"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7972903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="686" mass="75078" checksum="2432C7FEAA154872" modified="2023-05-03" version="1">MKKEPPKERSCSGIQKRKRDSSTDTLASLPSQKIDSRPASAPEVRADTPKEVAEPSGWQQPESVSSSDIQDLPFVTAASDYCQSANILEPPDAQPAEEGAGARALRSVGVQADSRSTASAFLERKKWREKERAWKQRNERLQATVDAYKKGLQQLKEECNDLYKMQRGSILKPVRFLTRKHLYPSNIEKMGVKPAVHLFSAAVTAALSFMKDDAGHTCDAKFTSVGPTVEFMNNKMLKTGIVAASHTCNVRSSASFVSSERIIRSGETSSTPSTSTSAAVNSAQHLLHELCTSSKPFLPTPDVAAVSLVAGYISRVVGEKTDCERCVSLVLKAKGSSTSATDGLISHQDRGGLCYPTPELVRVLHALKRFVDVMLLDRASLHKPLETYGRPRVEKLKRPCGGSADTNSVPRFPDFFRPAAVCLRASPRHHRNTSSSHDFLTALTAVRKSCIHKMQSSFDNQLVRLASAGFPGSLVTGVAESLLQKMKKRAPRAAAEVPREEVRPGAYLSSCDYDFRTPLHVASSEGNTAMVRYLLQHGASVHMRDRDHHTPLMSAILCDQHAVIELLVQAGAHLSLPASQLADELCTAARNGNVKRLESYKLAGASFYESDVTGRTCLHAACEAGQEAVVRFLLENKIWPETKDVYSHSPEEIAQLLGHVKLLQLFKSIVPTTNGTTRDPHQRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T737</accession>
    <name>A0A9D4T737_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T737"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="67" mass="7389" checksum="37661BEE83879616" modified="2023-05-03" version="1">MTTKKGARVLDVAQQHGLTLWNDALQLTRVGNSVSRDANSDLTFTRDVKKAGWTCLPETLGSDHHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7L3</accession>
    <name>A0A9D4T7L3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7L3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032184"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="15434" checksum="99B573352C01E666" modified="2023-05-03" version="1">MDLDELLPEIGAFGPYQKWIYFLLCIPATLPSVFTLFSSIFVSATPRHWCRVPEVEALKGRFSPELLVALSIPQRTEGVFESCLMYDLNYTALVHRALDEGELPQPNESWATRACDNGWVYDTTYYDDTLVTQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T963</accession>
    <name>A0A9D4T963_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T963"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036736"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="23420" checksum="807BF5636E7AB8B5" modified="2023-05-03" version="1">MSETITVMKEPCAPAGLFAFGFEIPALSLARSLADGALLLKGERSNRQESYSTARQPAVNTADKMKFLLAFAVMTVALALPRTKRAAYELPDGAELLLGGVKTSFQCPAKNGYFADVDNACLIFHVCNVVPKEDGSTEVQQYSFLCGNQTVFNQLSLTCAFAEEAVPCQNAPDFFYVNDNIGNPTAPFLTEADVQKAAPLIPGFGEGGGAGAPPPGRRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T988</accession>
    <name>A0A9D4T988_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_009795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T988"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038361"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF30">
        <property type="entry name" value="NEUROPEPTIDE F RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7983183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="415" mass="46437" checksum="F0807D04D237D454" modified="2023-05-03" version="1">MEGLGMSPDELMALLSQNKSGNDTAELHRQLERRLLSFLDRRAIDSDTLAALLAAYTLLILTGATGNGLVCLAVARRPKMRTARNLLIVNLAAADLLLCLFTMPFSLVEIALKTWPLGGTTCKLVAGLQATSVFVSTLSITAIAIDRYLVIVYPTKQHWCFSALVGMPLIWLLALLLSVPMFMYRVLDHIELPDPVRGTVVHLEYCVEHWPIEEGRFYYSIFSIVFQYFVPITTVTVAYASICRRLRVRLVAKAGPLNQSAPRQQHDKRRMHRTNVLLVAIAAIFAASWLPLHILNLVADSTPSLTADSRLYRVYFACCHMAGMSSACSNPLLYGWLNDNFRREFRRILSTCCPRLRARRASATGPPSESRPLTGQALVLFRRQQRPHTQDTCVEAAPPRPAEDQYETLIVLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAF9</accession>
    <name>A0A9D4TAF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052731"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43773" checksum="8ADAC7134C9F8A5E" modified="2023-05-03" version="1">MASSTGSWSRVRLELLKVLDQQGKTHGLKTAFSLGMLVIGVLEREHSYEPIPADVKAYSRLLVFDEGRENRVYLLDFGLACRYTQNGKHKEYKEDIRMAQIGTVECTSRDAHVGAHSRRGDMVHLRDNQLLWLCCLLPWEDNLKYPQYVSQGKSTTMEDVPLLLSKCSPHRDIPCELLEFVSFMKFENTPDYKRLKRISEKGVEVPRFKPDGRIFFKTPRTLRCNSFLPKKSVLQEIMLAEHSIGESGGENVVEKPPPAQVTSDYTAPIRKNNRWSPAATKSTSVFEGLFKLEPERTPLKKAVSSLSGRTSSEGSRRNGFCEDRNSMSLDNTTTTMLEMLQRKQALLAQQQEGVRPPGGNGQNHSSISGLRTVPVASVGGALTCISLQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBP0</accession>
    <name>A0A9D4TBP0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBP0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040203"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="94"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="429" mass="47302" checksum="BAC07F95215CE0E6" modified="2023-05-03" version="1">MGHANTMLYVTRVSFCIFVLFAMYLLGMLFYARTKARPSAPVIVYQRAAPCPSVVPLKTPTNTTSTPLSTTSSGAPTLALFSAPEQPKNAVPLYHLFCFFNRSEQESVTSLDVSQIPVGLCTHLVYSSASINSRDFTLNDAHRGAIERFAAFGQPSKLLITVGESRQDWRAYQDIASDRHIASNFGLKLRHWLHDRKLDGAVIDWPVPAKQKDATVLVRQVKQALDDDQLLAILLPHDQKRRRAMFDVRRLVMFADFLLFRMYGSHGLHRTEYPITEQDVSLFPKAARSETGREAFKKACMVLPLSGLSFVRDVSSASLAPGGPARGPGPAGRQSRKAGSLAYHELCTGNWTQVRASHYGTAASRGSMWVGYHDSTQLARIVHVLRRRHGASCFGLWTLEDDDLTGSCGATTFPLLRAVAAECRAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCI7</accession>
    <name>A0A9D4TCI7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024343</name>
        <name evidence="3" type="ORF">HPB52_025307</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001108">
        <property type="protein sequence ID" value="KAH7985057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000654">
        <property type="protein sequence ID" value="KAH7985908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCI7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042205"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7985908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="39062" checksum="CE0BF2386C1F2FED" modified="2023-05-03" version="1">MKEPRRGHSRRCRSVECRSENAGEEHLFRNPLSKWYRGRRRSKDDEAGLLDAEYDGGHESHSQQQVRGSRQSTVASISSSGGAPKSSTKPNKSSSSNCSSKKCPSSTTSPQPHKPTAANGGYGPRVRISLPEEDLSTRAKQQSRTAAHQQKAECADKSEVPALPPRPASCQPTQLPNKTRSLCPAERARLAFPGCHNQESGHSLSRDLTQSPARAMGVQSLDALLGQLCSGNCKISMKVKDKDGKAHKDKDIKVHKDDDSKTLAHKHNEICCMKEATQCSRRQSTTTCKETNPPSRQAQTRICSLRQAQLLVAIQLQSPPQVLHQMLPKEHEPSMTPHFYINGQTLTSRKAGHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDV7</accession>
    <name>A0A9D4TDV7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000303">
        <property type="protein sequence ID" value="KAH7986731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDV7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12006" checksum="BBBBF195BABD282B" modified="2023-05-03" version="1">MPPPKEHFFNVRTPPGTSVDEVIDALEGLVGIQDIYSVQHHGGFDFQVGVNSVAAVQTLLETGGLRLGTRTVPLVPVARQVASVTCLYLPCYVPDNEVVTGLKVLRNHVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE11</accession>
    <name>A0A9D4TE11_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000225">
        <property type="protein sequence ID" value="KAH7986898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE11"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055631"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055289">
        <property type="entry name" value="OFD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063:SF1">
        <property type="entry name" value="OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063">
        <property type="entry name" value="ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28414" checksum="B01F5258E3113804" modified="2023-05-03" version="1">MDARKELDGLTFKEMRFKMCRFLEEQGVVNDLRARLRYKFVEALTITTQSAQRSSRTLLHQVILWLIQDYLSSQGYEYALCTLACESGVNQEPFSVRDVEELLRLPHCDGHSVLQRIVTRMMSRPETASAQTSVAAMQGKTVHAELEKLQQSVAEAEQRLLALQQQLQSAQGEETHLQTVRHMSVLTELSSVGSNCILAGNTSSSVSSVSSLPLDRARRRLRRLSLQTDYLDDRLRAMGSARDDDQLLPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE94</accession>
    <name>A0A9D4TE94_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_024395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000113">
        <property type="protein sequence ID" value="KAH7987120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE94"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052571"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF372">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP76A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="77"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7987120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="428" mass="47613" checksum="CC6A4884FE1DC009" modified="2023-05-03" version="1">MERDLVTNETALRELLQRAVAALDDAGQQPSLLQPCRGSSEEALANPPPASHCTDRAEVRRGSEIGVHHVAASKARSALRRASRAAELFAAVVTALAGSRGDTAEQILAALGATHEEELLHEFGIVGRVLEPLSPLHVGLASKMYLSTSLELADSFKEAIHQEFGGQVGIVNFQGDPALAVKEINAWLYRVTGHKMNGMASVNDTSLSTRVLMVGTSFMRCLWLDKFSELYTAAMPFFADDGKLSVPTMCSRRICNYCHVERLACRVLELPCMMEHLQLLILLPDVQSDLAYIEANITPRDVQEFERRYTRNPLDITLPKFVLDEHVNMARYLAAVGIRDLFDKEEADLTGISDEKELCVHDFLCRSRFEVTDEDPVRLDIGGSNSLKLAERTDLPSFEVNRPFMFLVVERQRKAILYIGCLRNPNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YMP8</accession>
    <name>A0A9D4YMP8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YMP8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16258" checksum="296BE3B01921DBD1" modified="2023-05-03" version="1">MSGERSSACRRSARLVAKRAVVARVDEDGATPSRPSVEADSLATTSRCQSNVTSKSTRVSQPAKKLKTVQDDVGENTRTKGQDRTQRVSRHLEDEEKPKRGKKITLGKTSPKQQEAVATKSPAAAKRQRALAETTSSEPSRQAKMIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPM8</accession>
    <name>A0A9D4YPM8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPM8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11369" checksum="6EB9C651F295AC56" modified="2023-05-03" version="1">MQCSSCYQRPFERKAPGQHGSSYDLPQRVENGTASDNWFPWPSRGRQAHALPYLQKTGEAAARRESAGRNERRRERGGGAGEHRGGYVPAVPGLVGGFARRGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQF1</accession>
    <name>A0A9D4YQF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048541"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057776"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20901" checksum="4FAD7C88D3D0E2FF" modified="2023-05-03" version="1">MRDGGGGPSTCRPMGPSLALVRAAASHMATRLPNPYDSDGAHMSQPVLSLPPARIFESMVTGSEDTMEELLGKRERFGWRRCTLPPRSARSRTAAVERVLAPEVAARMEAIKNDERRKAELHAVELRLRRQQLSQQRQLHSMRMKQEQELHKIQVRLLEQQLEQQKSRFEMECQKQQQHPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQP2</accession>
    <name>A0A9D4YQP2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_018384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQP2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="559"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="690" mass="77244" checksum="0981DCB67651321E" modified="2023-05-03" version="1">MASTGPQDEPTSMQTEVNAETPATASAWTYDVNSGKTIGKEHIEWLQVGRKAKRASEPIQASKEQPEKEHMPTQKPPKQRNLMMPPFPTDDFKIVYRPQAGLDLSKWSLTAITHAIGRSSSLTQQDFYDNVRVQMQSVENIIIASTADTERATKLRSITAIQLGGANFSVNPHVRHPDDVCRGVIYGLLPGTSSAEIVAGLRVGLKIHIITFDGPHVPYYITYQSGDYRCKPYRKSVQYCRKCGAIGHRQDICPRPREDFCYKCGQGAVTEDHDCLPKCKICGQAHEASRKECKKKLRPNPPPYQVRQQLDKAKARENGCSSRSEDVPELDKACSSPSGAQRRKPGRSRSRSILRSRSTSRTRSRSRSAQCISYADATRELSSSPHNENTSDSSSAETTAFKALENRVLNQQKALQSQPEQEKIIQKQNESIEKLTRLCEEQRQAKQLATKFTTQEIEAVVEAKIISIIETKDAALVESQLTAIAAPITHSSSRTKLEPITAQIGDTFTTLSRRMDIHTAQINELKSPVTAQEHKIEGTTIEHTIVEVIPERKSQQSLYVTNVYSPPRDQLTDFDHFIRELRKRTRGHRLVVVGDFNAPHTAWGYAITTKKGARVHDVAQQHGLTLWNDPLQPTRAGNSVSRDTNPDLTFTRDVKKAGWTCLPKMLGSDHHIIQLDIGYERRPTKTGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQQ3</accession>
    <name>A0A9D4YQQ3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQQ3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19510" checksum="F0F2FBCDBBFBFC3B" modified="2023-05-03" version="1">MNKVREANETLRQGNSALRKTINNLSREIAETQSPQRPTPSSSEIEETSTKNQEAAVEKQALKKRAIEATPKQKENDCNDNLEARFEARFIKLEEIITANIAAVTAMKQTVDTCQAENINRFAYIERTLQPIVSHLTFAPLIALHPPNQGTLYARPNATRPRDSSNGSRPRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRN5</accession>
    <name>A0A9D4YRN5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000618">
        <property type="protein sequence ID" value="KAH7986020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRN5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="121" mass="12920" checksum="F63D282CBBDBED28" modified="2023-05-03" version="1">MTLTEIEADMIAGKRNAVQKKIGDFFAPSSADQVTRLHHIAQLYCGKVNSAGVLTKLRLEEDPLREGGEEVSSSGAACPMGLERPPLGPLPPSRRLKGCSKGPRLPPNMAAVPSRRSNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6WNW9</accession>
    <name>Q6WNW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Fer</name>
        <name evidence="11" type="ORF">HPB52_005828</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2004" name="Ann. Entomol. Soc. Am." volume="97" first="567" last="573">
            <title>Ferritin gene coding sequences are conserved among eight hard tick species (Ixodida: Ixodidae).</title>
            <authorList>
                <person name="Xu G."/>
                <person name="Fang Q.Q."/>
                <person name="Keirans J.E."/>
                <person name="Durden J.A."/>
            </authorList>
            <dbReference type="DOI" id="10.1603/0013-8746(2004)097[0567:FGCSAC]2.0.CO;2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2010" name="BMC Genomics" volume="11" first="450" last="450">
            <title>An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus.</title>
            <authorList>
                <person name="Anatriello E."/>
                <person name="Ribeiro J.M."/>
                <person name="de Miranda-Santos I.K."/>
                <person name="Brandao L.G."/>
                <person name="Anderson J.M."/>
                <person name="Valenzuela J.G."/>
                <person name="Maruyama S.R."/>
                <person name="Silva J.S."/>
                <person name="Ferreira B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20650005"/>
            <dbReference type="DOI" id="10.1186/1471-2164-11-450"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="9">Salivary glands</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2013" name="Ticks Tick Borne Dis." volume="4" first="469" last="477">
            <title>Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine.</title>
            <authorList>
                <person name="Oliveira C.J."/>
                <person name="Anatriello E."/>
                <person name="de Miranda-Santos I.K."/>
                <person name="Francischetti I.M."/>
                <person name="Sa-Nunes A."/>
                <person name="Ferreira B.R."/>
                <person name="Ribeiro J.M."/>
            </authorList>
            <dbReference type="PubMed" id="24029695"/>
            <dbReference type="DOI" id="10.1016/j.ttbdis.2013.05.001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="9">Salivary glands</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular cloning and expression of the ferritin gene from midgut and salivary glands of dog ticks (Rhipicephalus sanguineus) in Thailand.</title>
            <authorList>
                <person name="Kaewmongkol S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Thai</strain>
            <tissue evidence="10">Midgut and salivary gland</tissue>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="AY277907">
        <property type="protein sequence ID" value="AAQ54715.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EZ406186">
        <property type="protein sequence ID" value="ACX53981.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KP688390">
        <property type="protein sequence ID" value="AKN52391.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6WNW9"/>
    <dbReference type="SMR" id="Q6WNW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032003"/>
    <dbReference type="OMA" id="WNSAKDA"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014034">
        <property type="entry name" value="Ferritin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00204">
        <property type="entry name" value="FERRITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAQ54715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACX53981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKN52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7968111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19905" checksum="E985EC475246FC20" modified="2004-07-05" version="1">MAATQPRQNYHVDCEARINKQINMELYASYVYTSMAYYFDRDDVALPGFHKFFKKSSEEEREHAHKLMKYQNMRGGRVVLQPIQKPSQDEWGAGLDAMQAALELEKTVNQSLLDLHKLATDHNDAQLCDFLESEYLEEQVKAIKELSDYVTNLKRVGPGLGEYMFDKETLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAT6</accession>
    <name>A0A9D4PAT6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAT6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043346"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7934868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="34413" checksum="3526CA3B183B3615" modified="2023-05-03" version="1">MADKQGGFVLMTKGHFDLKAAEAVEKNFRRVQVCASKVKARAVALCNDHGLPKLAKDIIRTAETERCLNWFRRVLITDIGFGSLSSLSGPESCDSFFCHRRVSDAAVITATMAEESSPSSATPVERARRSLVRTSSHRRSESVAYTRMLWNLIASANTVRLRHEQAQRLCKVVGEQHTALHLPAPAVDADAIARGLATSGASCPTVSTAVSSDTSAALQIALPGFPNTVGRPMTSSALVSDSRNVPLPVDTEPALDDMDTTSTRKRTRPSESGSDDEGVSRKMQAVATERITVMSPTPPPSDTVAEERPDIHDADGTNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC49</accession>
    <name>A0A9D4PC49_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC49"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041651"/>
    <dbReference type="OMA" id="YFILCYG"/>
    <dbReference type="OrthoDB" id="6512920at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39790" checksum="DDF6957252E3AF9B" modified="2023-05-03" version="1">MVAWPPPSLVYTVAVLLRVGVVAAAGVMSRRRVLQQSAGSSSAAAAAVRHHEDVVEDADPAMLLPELVGHLLNEAVARVDDQAEAIRLDDGVVWKPLREPDQVKAAGEHVSALPELKNEPPHVEAAAAAENDVIPSRLASSAVRSRLLQRDAAETLTAEDHGAPKDDAARMAQNHPTSGSNSKDPANRSGTPNSRNGIPQDPNRNSKDPTASRAGDEQQGVAEGSPLEVGSKSTVTKTLDVADASVQADVTAPADTVVQPSSGGKTTAEPRQRVPTVDQGVQTDAAASTSKKSSTKDRYSQTLPTTPTLYSMATQTDIQEAPWYLFRTSVQKKKLAVMISAVFVLIYFILCYGLVSMAREMYAEHVFEELDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGG3</accession>
    <name>A0A9D4PGG3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGG3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046415"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17207" checksum="A2A74E50E902EC66" modified="2023-05-03" version="1">MVHPARAPTMGPMNEDAEPPRENYSAEIMGVVTRDAVVGQQMTAKIKLRVYDTILKELKMRVALFTPQGTVVPCIERFGSCVYDVCEDVPESKMTMWTTKCPVKPGTYWRNLVFRNGNLIAALMLESKGKKLSCQALHLRVFKTRPTTDIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGG8</accession>
    <name>A0A9D4PGG8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGG8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="572" mass="63283" checksum="2448C2FFD388BBB1" modified="2023-05-03" version="1">MSHGGDPDASAVIQWKGQLDLDRPCGAVGSGETCWLCEDFPAWNSVIHALNLELAETAPGTLHLRFVPNSQKKDLVTAAREASVILSSLLCHHLCIQEVYLECVFSTNTPAPQPLFPISMRRQSSSPASRSLRSLRISESGSLVYRRYTSTLANSASAWAAEIDALLERNRNTLKNVEIFEARPAQNKLRMVEHLAACKVLALKSLEYGDIAAPDVDGMDIPISDVSALCEALRVNRGLKKLKLSEVRGSEEERSSLARQLLEDNCYDRVHLGHWTEPYLRVLSPVLASSDAGTTELWLWNIGELSHDSVSALFNALASNKKVTSLKMDVMLEPDHRVALLCETLKKNRFIEFLSINICNGNCANEILRALTVNSGITKLEMALRVPAVEKTAAAFSDMLSRNSAITHISVDFDTDDPRPLLEAYAQGLSGNRLIYRAGYGVRGGTYIPPSLNVPVRRNRASLNRAMDFVLERREDRHCVECFELFFGRSCLISSLVEIAEMSGVEARVGVASAENRRQEKYMIYPCHTGKLNRCYTQLQLADVTTVTVNQTEASSNVPLFAGLPTSRKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGS8</accession>
    <name>A0A9D4PGS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046068"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF24">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58088" checksum="619325585B4231BE" modified="2023-05-03" version="1">MFGTLSDDHRQGAELLPDDDDDLVEYTKLKRMSDKKYENDIKQLVLERKIKEALNLFFEIQKAYEVKPTHVMFTLLIGGCGRVGYTKMAFKLYRMMRDRGLEPTPATLTGLFNSCAESPFPEMGLDKAHKLYEQIKLKNWVPSNLTYHAMIKAFGKCGDLDMAFRVMDEMADAKHAITTETFAFLLMACISNKEAGFSLGLKVMRTMLWKKIRPSVYCYNLFLRTVPQTEGDASEKVFETTREAEALPFDEPQRTATSTSLATLPNLLSPSFEHTGEIVGLGEVTDPFHRLLMVGGVKGMMDHFRDMSVRPDSKTITMLLDCIPNNFDAEAELIAEADKIGAKLDVDFFNMLIKRRAFRREKETAKDTLSMMTARGLHPDVEAGLTVNEETWGTLVCNACFKGNFWFLLDLMGYAKRENILVSAAALRAIDKAIDRTRRALLRKERGKEVNFLSSAMESGFRQFCLVYEDWLKEVRVDTPRHPWEQYEPENLKKSAAELKAAAVALTTEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGU2</accession>
    <name>A0A9D4PGU2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HPB52_014830</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Rsan-2018</strain>
            <tissue evidence="23">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGU2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026234"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7939601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="256" mass="28303" checksum="F19F6E0BE03F302D" modified="2023-05-03" version="1">MSDDLNGKVALVTGGAMGLGKAITDRLLQQGCRVAFIDLNERTGMGTESALKATFGEDRVIFMKCDVTNDEDFEDCFVRVKKKFGRLDIVVNNAGFAGEEHWRRIFEINTMAVYFGTLLALKYMGKDRGGEGGYVINIASIAGLIVCPPIPAYNASKYGVIGLTRAFGTDLYYKRTGVKVSCLCPEPMETDLWHGITSFCQEIALNTPYITENYSSRVQSPEETALGVIKLIEERIDGAALIALRTGKFEYHEFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHB4</accession>
    <name>A0A9D4PHB4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHB4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="39443" checksum="D873BEA72020AF52" modified="2023-05-03" version="1">MEVAVEGHTITAEEFQADHWTPVLYKAYASRPASSPKPLPYPNATFEAANPNARNAAHDAAAATGSGTTPARLPPATKQTRITVKRSKQLPPLPPNAIRVVVHPRGELRLRDIPTPRLTKAVQGELQITLPDDFCLRIHPTNNTFTAATTHSSTAEILKTLTSLTIGDHTYPCVAYVAAPPGATRGVISNAFDDETPTQLYQDLVRRNPEYTILAARRMGKTHSILITFDANEVPHSIKYMGAIHRCTPYRGSPDACTNCRQPGHRYDVCPNPKSNLCPRCGTQHLPQEPPCTPKCILCEGSHLTGTGSCKGRNLHQPRKQTKQPKRSNKNRSHTGTTFPSCRQGPFSPPSPANTSKPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHJ3</accession>
    <name>A0A9D4PHJ3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHJ3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="574" mass="65041" checksum="675D8463A240C365" modified="2023-05-03" version="1">MYVREAAAPIDKAAPCLDEWCDRLGLWLLPNKSNFAKDPCHNFYEYVCYDWSVGREDTSFLGSVVGSAYNIISDRIARSTMPALTRNDLDLFVAFTKVCLADPSFNDSVSEWMSLIRYEMGDDFLVLRSWNWSRIVQATIRHNLLYGLPTIAGVRVGRTQHQPNRAGLFLSVDACLITLFSLSSGDTPAIVSLLTEIIDELPEFGDVVNAATQVKRLALAINLKRGAPFEEKMSCRSLGAIARGVDASTWLKEINRYVPANMTLDNDSDVRIREVTRHSDLYHAFEGRPPAIRALYINLLTVGQILQYRQSHATNVLPKLRVCMHASRNAFRNLWVKLVMDVAGLQLRPLSGPTVENDTVYRAPQLSIGYHMPQYLVQTSAFQVKRSYNQFIDEYSLSGDREAINLKPTYNVDDLTISVHFFLLFPPVFYVYREEQFHNFATLGVLLALELIREAGRRSLLDWQAAAERGQTCRLEPATGSDAQIKELFIWELAVGAALRSLEIYAKRTMSPLETLHYGKQLRQVFFERFCMLSCMPKNTESTKQRCVVPSMNLLEFSVAFQCAEKGTRKCGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHJ6</accession>
    <name>A0A9D4PHJ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHJ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039524"/>
    <dbReference type="OMA" id="RINACTK"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="282" mass="32610" checksum="731E148F601BE2F9" modified="2023-05-03" version="1">MKWKPLPYSRNDDHRSQLSEAALKKVRFQNELTEERQVIEIGGGTGYFARQFLLPHCRPCRRLVATDLDPEMVEFATEHFSHQDIVRDVLDIVTPDLTPFLEKYGKFQRAFAFLVFHVIQDQRAAYENIAKLLTDDGECLVVAYSSFDLVDLWKDVYDIGKWKGVIPDPRSVLNASFNFNQIKTTAQVESEARDTVRGTGLECISCEVYDTLWKYDSLDTAVDMFLTVVPFKDTVPAEEWEEFRNLWLKIARRKMSPIPGKPVEVKHQLCAVHTRRSNTDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJF0</accession>
    <name>A0A9D4PJF0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJF0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="208" mass="22898" checksum="5E42F29598FF5E37" modified="2023-05-03" version="1">MNVRSLPAHAVDVSHDHVIREVPLLCFTETWMDTAVELQGCKCVSLAKRQNHRAAGVAVYERFDETTLLPRSVPYQLISLPQMTCGDACAVKTSHGFVVAAVNISPSASRKDIMNFLLHNFSTVCQQDVPVIVTGDFNVNVLRRDNEWLVAFLGAELGLHLLSDVTQPTTRNNTCLDIVFGKGVASRVHCVPLPTYFSEHKAVVAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJX2</accession>
    <name>A0A9D4PJX2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026351"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049422"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1531" mass="170945" checksum="5443E37079D517B9" modified="2023-05-03" version="1">MGAVPSSLCSEATRSSSMPNMRKHLDWVTTRDTESHSGSDAWQSWAAATPAEPSAESPLVPPVSLDGARGPFTGSTIDYTAACTATEHRACQIVCHLAVWNEFLLPARLELREDSSSSRGPGRLSLVSYDKPSLRHPTGEELHMSATLVNALLKIHGCVTHVAVVHIWSLKSYATLLGDALRYNCNSSIRYLTLRFESFSDRSVWSALSSLVQLEGLQCLSSKECPDEFLETLSTLLRKTKSLRALRISELQINRRGWGPMFVGRLSRSCTIEQYDDSCEDLVAVDHDMKNYVVERFMQALKGNSSLKELALNESVVDEASHEAFEGYLTKNSPLSSFSVVASSDLNRFSADRVLKALLKNTTVTKAALIGLVFSEHSALLVQRVLARHRSLRSFEVSMQRHYPYRMLQGFSPWTEFDDWLAALTQNDIVEEVTFTFHTAFVFSDRNKWEAFAKQLPTRKNLKKVTIVADRDDAFLAVLCRILAQNGADDKVSFRPYNVHDNLDLLQCRGFSGVYAHLFQTPDPEFQRLLEALPSFRNVTTMRLEVWMSCMEEVSSSIIECIESATSIRELQMISSLHDASTTDHWAAVIESLSRNDSVREVRVQANVEDPRHASVLARVVKDSRRISKVHFNVGGTHETAALVRCLSDGIGDSYNLVGISIEGRLEAEEVIKDWFAVRDVTRRNASLFNRAMRFLVADECWDGFDAAALEQTSRHPVLLAKIADELRISETDAALKVRHKLRVSEDLHTFMRLAGVVRSRVECHRRVDGDTLTQLDDLNEHCWLYVPFAVTSFSQTTDPRKLVGRAALDKPAAAKHKVRGAGRRVTSPKKAATTPEGPTTAPDQAELQEDDDDFGGRGRNVADRSIRTECNNSLCRQLKDWFVNTVGRQADPCRKENTFVCDSSVTFPSFPANDTKHSADKNESSDDSANEHYKYGPIGADGDQLMKSCAEYARNPEEGVQDVLSFLSRFNLDIRHMVDDPTEDPLKRMMELSLEYGVDAPVAFSRKYDVIGEASAPFVIDVILNHEMNEFVAASRTMGEEDIEGFYQTFLRRYALVENTTIKEQLMDSDDEISEFVNDRYGSDQPVKMSIASLSNSTGVTQDRWKELLTLFGRSKHASYEHVTADEQALAMVTYLSRPDQRLHNRLVLAWHVLRYLVGPKLDVLAALNRTGAYGDLDGVVTLTPEDKCQRLVENVVGVPYKALDMLEGGNTVSIETISDVTRFMAEFQDAAAFVFRDGTKLQDVVAKHADSAEGSTTAARKQVALFPESPAGSADAEYFFRALGDTRTDAATTTEQGQAATAHTFPKLWLRRLRAWHALPPLVQALLPAMASVVNVDSLTAFFRPPYYDVRAPPAYNFAALGQIIAQAMAHELIKRQRDNPAVGERWRRFWDEGDHVTGGTVYCLYTGYNENGTGWQSRVDEGNLTKGARLDELLGSRIAYLAFLRARHFNASDSGHTRTLPGVLLSSKQLFFVMHCALSCAMGGDHGPAVVSPPDQRCMVTYKTRKRFIDTPCGKTSGERVPNECQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKS1</accession>
    <name>A0A9D4PKS1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abasic site processing protein HMCES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Peptidase HMCES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">SRAP domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_003210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKS1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051667"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7946686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="26086" checksum="3E02563458ADD8FD" modified="2023-05-03" version="1">MAAGFFEWKTEENGNKQPYYVYFKQPRGIDMTRREWDGVTDAHQLMHNGHWIGPRLLTMAGLFDVSTSKDVLYSYTILTMDSPRYLQWLHNRVPLILDGDEAVASWLDPNYSFEELTYSVRCPPNLVCHPVSPSVAKVTNNTVECVLPYNNGESRSRSTVRSASFRSSRSSSSSVRSRHRSRSRNASGAVRRRSKPRHRAASDSSERRQRKHSHRRSDSHRHGRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMQ5</accession>
    <name>A0A9D4PMQ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMQ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045694"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="8">
        <location>
            <begin position="702"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108821" checksum="D0D0074B93952131" modified="2023-05-03" version="1">MAQSSFFASGKTKQQASEHIPRQVVFQRRPKSICADQPDLDRRQLEMVPADSRDYAGPRGEPAREPSPFRLRSAVSVSRTTTQTAPVWSRLAVTAGNLLFLAEPHLPCLAPAHRMVTRQELVALRANSPKVEPAMPMAILKSTWATRAQRLSAVGLLLSLPMWLQWFGSQQETAPATPPAGSAGDGACSSLDPRRVRLALAGVWAAQQANFRKAPSDFNLGVYLYDTCGRDDVALRQSVRVIHQAGHVRSMACPTTRVPPVFGAILQGDVEAVETAAKTLASFSIPAVAARDVPAESVRRLRNLYSTAPAATSLARALASTLRRLGWSYVAVMSTAEDRPRELSRAFLRVARDMAIDIMSADAPTGFSYQQVQEALGSTKQLVESGCRAAALFVTPAEAKAFLVSYEPDPDAAFSWVLVTPGDVTASLAGLLAPHKLRRLRHVLFAAPDDTQRPAEYGDYLRDLMDRDGSAPLLQELRKTYSRNDVVQRWDDEMSDSADAVAVIRAVWAMGAALRAVQRVQCGRGTDCLFGGRQGLSASVLEALDSLNFNMAGAGVASLSDTPLKFSHERHVATLKYAVKAVSTSGEVLQISVYTDDTGLEVDDVLVPTRGPVIRGSAVEAGKTSVKPSTRQRSSNLRSSNLEIHNEGEPQPLGDDTTSSPSLSQTASDEDYGALADKTSTAPGAVRLAKPKLYTIWIAKPWTLAVVIMSGLGILLSAYVAVFLLMKLCEGVVRKGHQLTSLLLLLSVVSLFLSALLFTFRPKPRLCAVQQLAHHTSYAFAFGALLLKGMHLNAMQSAGLGGRASGLNQLLTICFLVAVQMALEAQAWMLSPPRWCKLNQTRFLLHQAYPCVVLALAVLMAFRTRNCSYHRRDARSLLCTSLLAVPILAAGHTAFLLLGPGEHQIAALSFALIATGFLILVGIFAPYLRALHKRGGYGHKPLSYSDSSASAFTTFQHHHKDSGSAIPECCYVRGGRAVTIVQQSNRNGGGPSHHVRNPLYIPGSAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMS6</accession>
    <name>A0A9D4PMS6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMS6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="179" mass="18867" checksum="CC095BF7BD45E5AF" modified="2023-05-03" version="1">MKTNRKGERSERCARGTPSWRARAEENGGQGDGEDSRWSAQSGSCPSPVERGASLGEQRSSRSGRPAGRLCSELPGQVSAYAADLERARACGHPSATPTVPGPGHANGARARVSWDVPGVPAGTNPILQKTNNARVRHSACGAHFYINGDFGIDGRGERRSGDIANDLPRKRPAVAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN50</accession>
    <name>A0A9D4PN50_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a non-catalytic accessory component of a dynein complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN50"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041923"/>
    <dbReference type="OMA" id="KRFTYFY"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7947976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10759" checksum="80BE3FF5A79827DC" modified="2023-05-03" version="1">MAVSPQAMNRKVVVKATDIPDHMQQEAISVAMAAIEKHKILRDVAAFIKTEFDRKFGPTWHCVVGRSFGSYVTYETKRFTYFYVGQIAVLLFKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNA3</accession>
    <name>A0A9D4PNA3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_015999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNA3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049099"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7947814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18929" checksum="BE8611384AE8B026" modified="2023-05-03" version="1">MALEGNVLNPYWNWCHNHPVEAPAHTTISSNLVKEWEKYLNSCGVLTPPGEHRILSERLLLRETLWMLRGTKELFAFSWNGTDFVVNDNFKLTHLTQAAVKNSLEEVCRYASYVAHLQDFISATAGVGEETSVVSLTYQAFANSVAEQLVPYNRLLVDIEKASRWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNI0</accession>
    <name>A0A9D4PNI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="7">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_010060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026744"/>
    <dbReference type="OMA" id="WGEQESN"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000012">
        <property type="entry name" value="Wiskott-Aldrich syndrome protein family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="9">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7947318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="574" mass="61356" checksum="6A780FEDE7EC9999" modified="2023-05-03" version="1">MPLVQRLIEPVHVSRGTLPLDARGAPAVQVPSELECVTNGSLANVVRQLSSLSKHAHDLFGALFQDATALVTRAAALQERVDRLALKVTQLDSTVEEVSLQDIHMRKAFRSSVVYDQQVVCRGTMPAGMLEMYQACDKPPPLDKLNPYRDDGKDGLKSYTDPGYFFELWRREMLKDTERIMLDRGKKLVHSKDGAEPNRVRPEGKKHKKVRQPHNTRERYRQLATTQEFLDHTPIYGTTTPYNNNVRAPAPGAPLPHVPLQQQPQVPPATLPDGPVRPSSLELAPGAHYPPPPPAYSEHVPPQSPNHYPPPPPYVEQQPQASPANGNGTPSRRPRPSQPPPAPPTTGSVSSGTSSPSITGGTPSSGASRHRTTSQRETLPPPPPPPEAGGPVVPCVVDAPPPPVHQASVDNGGADNMELPPPPPAPDTAMDSVVGAGVAAAPPPPPPPLPPANGMTVAPAMVNGGLSNGMLAESESSGSSKGGGVQKEERPTPAPVKGTTPAPPTDARSDLLAAIREGIKLRRVEDFKQKQVEKAAQPHDVASILARRVAIEVSDSESGSDSEYDSDWDNETEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP32</accession>
    <name>A0A9D4PP32_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HPB52_007528</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
            <tissue evidence="22">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP32"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036040"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="10" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="15" id="KW-1053">Target membrane</keyword>
    <keyword evidence="10" id="KW-0800">Toxin</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="21">
        <location>
            <begin position="106"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="20">
        <location>
            <begin position="708"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7947097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="105107" checksum="5535454C00B61836" modified="2023-05-03" version="1">MARGAPSESLIWQWNCRGFQRKRALVQQHLTLLDEKPLAIALQESGKAAKLSGYQAFSSDKGDKSRVTTLIKRNIAAIEHEVNSREIEAVLLEILTGRKDEPSVFLLNLYSTPRQRKVRFRALFRKAIEAAGTNPLLIVGDFNAAHPEWGYSKQDPKGRQLWEDAHELGLTLHTDPSSPSRVGNSVCADTSPDLTFSKNVTDLKWTNSEWNFGSDHFILALILKKGVKTRRARQPRITDWELFRDKRDQSATDKIENIDKWTKTLARHVEEATKTLDGDDAPEIADSKLLHIRCDEMEGGMSLAKTWGLLRHLLDPTNSKTQSGIRLSKARHAFKGTDAEFMNKLTALYIGDTRSTALPEYNGAPNEELDAPFTEAEVRAEILGLKTKSAPGPDGITNKILRNLDDASISALTEYMQEIWTKGVLPSQWNRPTARTWTSVCKVTPKSLKIIGYFAENPLHSNKPSAWRKKPRGVKTSSPASNRGGAGPRCLGLCAEDGEPLHIAAEFGNESVVKLLLNRKDVRDFVCKRNANKKNCLDMAIEEEHRDVVEALLKSRFWKELLQNSTDSEQYGTHQTPLRNLIRTMPDLATLVFNSCVTVEAGSDEDPNKSVTYQYQFLDDAFCGCGADDSGDESDSDSDSPAPGKSANERRRALLGHELCKSLLLHKWESYGRYVYYSTMSIYLLFLGCLTSFAMGTPAPCPLDFPHFNTTCSFISRYNTCAVIGEASDEGQYMQTDFARKAKIIIFMVSLIFLLKEVFQMYNTRWNYLDLENLSEWSCYVCSLLFVFNFTDCSASTGVPEPWQWHLGVVSVFLSWALLVIYIRKLPFLGIYVVMFTNVLSTFCQFFMVFFLFIVAFALTFFALLQNQAPFDTPWKAIMKTTVMMVGEIEYDSIFTENVLPYETSSYILMALFIVLHDHHNVQLARRSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPA1</accession>
    <name>A0A9D4PPA1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPA1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055287"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="664" mass="71686" checksum="A7748710C415E2F1" modified="2023-05-03" version="1">MAAAAKPNKDYSLNIDDAYASPATMEKYMNSYSFPGPVDYMSAAAMSPDGGAIDFYPTMTSGSVFDNFAFSPTIKLDELAAYQEPRGHMFKESSRDKGKKVWRLKGVADDDDDAVFDEEGTRPSTTKNGGKHEEWRRPDSKRNSEESRSVEEQGAAAAPGRRRRPNGNSGSYFRGVPEQDEDSSEEEGGDDAPREDERAGTSPATSLSGRDEIAYSRGNSRRPFVRVKNSGALTSEEVSSSEEGQRAAAMPLRNYDTGPRGNGDVRGSTTTANQRFENGRRRNVGNGGYGNSGELPSFVAETSGSRAEGAARVRGAANGNDNDDVRDVRYNSYNGNNIDDSALRTASGAMLRDNLAATLTTTTTTSTTARPDIENGLILLNGNGRLAAAPQQPERSAKSRRRPPLAYTPGSMEYQSENDDEESSSRDQEETTTNGYSTTTTPEPFSYSSEEEAAPPRQESRFSAEERIHAMKRPTQTAAARMRRPVTGELGAAAATTPLTNGRSSATANAQRNVNNGRKRGGYAAPAQMPAQMPAQPPALPPASSLVFLSRDPTPSADQKAAATATTGADQRPAATTGAGGRPRTLFHQQGFQGPYSYRFGFDTADPYNPQTRYEEKDADGRVRGSYSYLDPKGRLQVVRYEADQQGGFRVKGSFGQFPGDTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQ54</accession>
    <name>A0A9D4PQ54_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_001934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQ54"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039351"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="399"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7950808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="571" mass="63553" checksum="9FE887CD027F8807" modified="2023-05-03" version="1">MDVVQVEGTTLREEDYDAADWTTIIGTYRGKSQSKARMKDLPEASDKQKAPEERTETLTASAWRPTYRPNPAQLRATQQVTRRSRQMAPLLQHAIKVIFRSQGGLFMPNIQPQLLLRCLCATAKIPVDTEVQIRVHPTNNTCTVATTNQETALNLVKIKSITLNSKAYVVAAYIAPAAETVRGVISNAFWDETEEELLQELQARNPEAGILLARRMGKSKSILITFSQGPVPRRIIYYGGVHLCTPYRARPEACTNCRAPGHRYDVCPEQKKPRCPRCGEDHGEDRSRHCVPRCILCGGEHLTGTGWCKAKQRQITTKPPARREPTGRQQLHQEGFQGWHPSAPSKTPEELTWAERVTSKPDPRDEELARLREECGVTRDIQSRIIGGSRARLGEAPWQVSSIRRHPKFGTDGANHDIALLKLAEPFDFAGSDGYVAPVCLPDKYHRMEGSVTITGWGKTRESGKISQDLHVVTVPVGSDLFCTYQYGQLITLSSLYDRRIMFCARALLGGRGSCKGDSGGPATQTEKGLAIVVGIVSFGRGCARARYAGVYTKVSHYVDWIRDNSKKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS11</accession>
    <name>A0A9D4PS11_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS11"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21415" checksum="87CAB4C3ED56DFD2" modified="2023-05-03" version="1">MKLTKNKRASRRSQSTRIVNEVNQLIQSEQLQLSTLHVLHSRLKVVKTELGALNAELETFMTDEQVAEDYDSVVEYEDAATSCLALLKHHLDIITWTWTAPHGQHHIDMTSTAHSPATADGDPGDFAKQHDATSTQLSSKQQILWSQQELLLSHNSHKGSPTTKLGYHKRSFHQEEALFHSEKVAEQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS32</accession>
    <name>A0A9D4PS32_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_017329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS32"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042320"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047726"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053596"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7952034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="520" mass="59328" checksum="13EEE1D40A947BAD" modified="2023-05-03" version="1">MVSEVGSEPTPTYVDQKSRLTHIAGQGFSLASAALDHSAILKRAWRLQELDQQARAAQHYREQLEEERRRRIEEMRQRDHVGSRWRNARLIWEADHERKEAMAKRNMERESSTQHCKSYEHEFCFWQLQQRLRENRKSVSGRRRNNSGVPRRSSCAWLSNSVVRRKRNFSGPLRSSKSGRLRSKAEREEQERKAREEAERQRKELEERLKREEAERAERKKRVEEIMSRTRRRGGKDHPAGNSPSVLGRSSPQLPQDKSSDDKGTATQQEHKPEAAAREPEDVAKDMGSGEQQGGSLGNVAMPAAGSADCENGRGTIVESVNNVVTEAVTFFVVRKGRQATLGLHACQQFGLVPKAVDSVRCSEPAPEKAFPDLFQGTGCVGKRYRMVLREDAVPVVHPARWVPLALREPLRQELERMETASIIKKVDVPTEWTEDQRMLRRNRQHLLRIPGNGTSQDQDQDTDSPEDMFDRDKSQDCNTPGEQSHRDQQGMVEPTTITQGADHEGDNFSDVTSESLDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTU2</accession>
    <name>A0A9D4PTU2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTU2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12176" checksum="05DD5EAE4FFD4725" modified="2023-05-03" version="1">MPTRCVPERTSGDMKKSARHFFSAPSDEALRSTRNRSLLRADKESVKNEASLKVRSRRFFPSLPSYLSSPQQRKRESVPETTCQCAACGLGEQNSGYKGSLLPELKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTZ9</accession>
    <name>A0A9D4PTZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTZ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="337" mass="35434" checksum="3ACEB8E67CEBF513" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGAQPFHDHDLPSPATTPPTSRHATSASIPAPDHPPDEVQEVPAATGHSTESSVFSTASAHGPSDVPAICTSSPTSMAHDTAATSDSTTTTSAHALEPAIDTDIVTPAVRPPIAEASSAMSNEPAFSTSTLCASCQQELPSSSKSPVVDVQAHNQLRPNVRDAATMTENPEDHPPCLPQVDQTASCSSRIQYCATANAVTRTVAASTASPAHPGYVRADIRLNPLAQTYCAYAPPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUE8</accession>
    <name>A0A9D4PUE8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUE8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="9466" checksum="C3371F4E111EA390" modified="2023-05-03" version="1">MEGGADPIATQSVGEDEIVVDSAWVAASLKADGYEVIVDADSLVLQPRLRLKRALVVSLANQHRLRLNRAMLEKFKGSGVGHLVLNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV56</accession>
    <name>A0A9D4PV56_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV56"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="26631" checksum="E66ECF25707ACED6" modified="2023-05-03" version="1">MRYVHTHFSPNDPATPCFISYCGAMYSDVPALLEYLPENVETLSLHVGTNDIVKTGCSKSLDSLREALRRVRQVRSDITTVHISLPLPRAPNRRRHDSNWRFVSWFNREVQRFNKEARRLCHCGMLGAGVFYVEHGFSALPLRRFLAADGLHASFEGVALLAQHTRVQLRRSSATWRAAPTPCTPNSGHQLTQQQTPEEHTEPPRALAVTTSPLPPARRYNTRRTYVATTKAATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW41</accession>
    <name>A0A9D4PW41_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_013467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050785"/>
    <dbReference type="OMA" id="ILYERWL"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Domain A (catalytic)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Domain B" evidence="8">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7956889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="354" mass="39655" checksum="D5E0FE0610DE8047" modified="2023-05-03" version="1">MIATATINGSFGPRRQHSSSPLRSSSPTKRRRATASAHHIQPGKIGCVVDGRKPLRKRRASVIATAMGAVKYNLNQWVEDNKAYFLPPICNKMMHSDGQLKVFCVGGPNVRPDYHLEEGEEFMYMLRGDMLLKVVEHGKVKDVVISEGEVFLLPGRIPHSPQRRANTVGLVIERERTQQELDCMRFYTDESCQEILYERWLQCDDLTQKLANLLNEFMASEEHRTRKPGPKSFLVKPAYEPDGSTTLEAPFNLNRWLEKHRAQLDQESGKRDLFGQGHQTTMVVLGNGTHGTQCPGTETFLWQLKGSASVTIAGRAFTLAENDTLLVPTPGNYTLVNQPGGRTLATSMPPKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXV9</accession>
    <name>A0A9D4PXV9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXV9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10335" checksum="ABAAEA4CA1D11A55" modified="2023-05-03" version="1">MRDLLFRVIFVDPSSPPAPRARVGAQAEPSQGEFAFQKTLIESLRKKYQAMRQALGTTNYDSMAQFWERHVVMDKAEYISFLPAGTPRATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYM4</accession>
    <name>A0A9D4PYM4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_004340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYM4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041609"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF5">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7961161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="27798" checksum="F6FFE103294A7E05" modified="2023-05-03" version="1">METRCECAASTTTEHPSSFAGPINRRVVLKSRPGVDGEPQLSNFATEQCATPQDFIDGEVLVRSVFLSIDPALRCRMNENTGVHYLTPWLVGRCVEGLGGVGVIEQSHSPLLEKGDIVCRAMSWPWQLYFKTTADSLQKLDVQEVGGDVSIVLTCLGLTGLTALLGLREKGGIKPSANQTCVVSAAAGACGSLAGQIAKLEGCKRVVGICGSDEKCDFLTKTLKFDAAINYKTQDVDKRLTETCPDGVQVSRASCLGRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYR0</accession>
    <name>A0A9D4PYR0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYR0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049738"/>
    <dbReference type="OMA" id="YAWMVNA"/>
    <dbReference type="OrthoDB" id="6504555at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="961" mass="105369" checksum="03C48A5794090887" modified="2023-05-03" version="1">MKTSVDPEQRSSAGNPSTKSLKGSTESAPDLANKRSTAGQETAKGRAHRKSSASTSTAKHSSSLSQKQVAGGRQSTEKKDGAAPEKDTKEAGFDVVEEEPAVDPREPLPNRAVIDRRVSMGEVLPTEPPAQFLSQAHDGDILAAIMEACHGMEVGAVEPQTDPREPLSRRASIDRRVSLGHVILTMPAESSPVRSASVTGDYGESSLDAPKGAPPEAATDSAHEPRPDPREPLPRRASIDKSISLGKVVSMAPPPRSPISSRTSSGKPSPGWSEEERRRNRQAMTRLAALSGLAVFFMALAILSLIVVRSAYFRASQRFEVCDTDECVQHSKDILATLNKSANPCGSLYAYVCGYDARPEGTPYAGPLVHAYVREVMTTLGDAETFLAAKQRYAAATKAFAAVVNCIESNRHTAADDFAAFMHDRGVPWPLRDASSRNTTLFGVFDVVLDLVVNWRVALWFDVVVSQTASHDANPAVIIREPGDLVALRSEQLTLFDDVTYNTALRKMSLYLTGGKVSLDDAAVKQLRQDEAAFSQIVLASVEDDDGGDGFDVLLSLGNITQVFGAVLSVTEWSSLLNKHLSTAIRNVSNNTSMLFLNKGRLGRLGRLVESLPATRVMDVIGWTFSYAYAWMVNAHFDFPAQATTAGRLEINALCFVAEQESFGIVQAAPIFRDAFDVNEREKVTAALQKTSEALIKQVLASPAISNYSKREAVAKLDALVWNYWLWPLDPYLQVHSALNTLYANFSDKPGSVFESWIRSRKSLRAALATPHYERLMTSRYRWQSGGVRYIYSLNELRFTLSALFPPSYVRRGSSAMTFAGLGFKVARQMARSLDMHGRTLDSTGSTIPWWQPANSKQQQCRFDVAESDMERSLLIDQFAIEVALEAMQASSALRPSKSPKRLKFLEWLSDEQTFYVSYCSHYCSEPRGQPACNLAMNSSQFDDVFGCSRSRSNSPACVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZZ8</accession>
    <name>A0A9D4PZZ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZZ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037620"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="39700" checksum="E1754B1F4F8CBCA5" modified="2023-05-03" version="1">MLTRSKASAATAIVGGSAVNPMEDDTSSPAVGPAVPTTEGSLAEAAGAPVSSNIPPPAPRQPLPSEFDVRGTSTHPPQSSTGPSLPMADCLQALASQGGADRRALMQDFETRFATRLLSLETALAQRTSTADDVVADLAARVSVIEAQSSRQQRVSTSVEQYNIGRAQSRFFGAHLLPPTSDGTTSWAAFLVQFESVATLNGWTVQDKAQVLVLQLRHAAAEYLEYIPQAIRSNYEALVSALESRYGDRHLLQLYLTQLKHVRQGRRNLQELAAHVDSLARKAFSGCPTATMDLIAANAFVDAINNRNVQRFVRLARPIDVPSALMPTLPVKLGDPPQRVEALVDTGAAFSFLTSINPISSWLTELLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0T1</accession>
    <name>A0A9D4Q0T1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0T1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="242" mass="25376" checksum="370C4A57564FC65C" modified="2023-05-03" version="1">MSAQGAVQADITKRRCPGPRRSPGARYKRPRHAYPIPAAQKSPNTSNQGGAEAAPSRPDAPGSAEPVVQGPSPAPGTNHKTRSVATWTFQAGTEPPTSYFSAAPWKKQERAQRSKPENRLFAPFQGRTIADINRQARGACLPPTPGVGGGTKDGRAGSAAPATDDIIRRLQTEPQFARWVASLASGATTQAPADPPSQPPTIEQRSTPANATPDTASTDGPATPVVDETDCALVDLDFDVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1Y1</accession>
    <name>A0A9D4Q1Y1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1Y1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="18224" checksum="4D75A51C0D70F979" modified="2023-05-03" version="1">MKQRSNKKKKTNGEDVTVIYQWNCRGIRNKEAELLLHIDALEHKPDVIALQETNGKPRLPGYVTYTDPTEEGTAVLVRSNVAATQHVTPQGGCEHTLVEIHARTIGNTGNLYVMSAYCRPSQRQYDFDRVVSQAKRLAGSRPLLILGDFNAPHTSTNRRGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q245</accession>
    <name>A0A9D4Q245_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Organic cation/carnitine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q245"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036784"/>
    <dbReference type="OMA" id="HNIELMK"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7961721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63658" checksum="27E7E9A27A0D79E9" modified="2023-05-03" version="1">MSFKALLTPSRPTSKDLFTSEYFDCNDAFGHGPFQRRLMMLCALGAFLANIHALAFPLISKSVQYRCKQPHTNDSKAVVKNGTTSDVSGQIGRCLVYEDPADPNDTHTVPCVEWEYDEEWAKSTAVSKWNMVCQRKPLIVVMYAIQNAGPAVFVLTAGHFADNFGRVPVLFTAVAVLWVSTVGVCMFGDYATHAVFKFFSSGSSILTLTSSAISLFEVTTHDNRPLSIAVSITIGLLAADSWYFLLVPWNLRWERKLSVFLLPALVLLPAFLTVDESPRWLIATGMFDRAENVVIAAADKNHFPLANAACLVDSLRVDVTRRLNRRKSTCAEELLSLFSIRRRALVLCGCFFSNSFALYAITFSKGQLYTPWLPFIAFAFNSSVYGLAHVLMRRFAMLTVITILFAALCSVQCFLCLTVFGEHDVLTEALLQADIALYYSGAVVCFVYVLELFPTALRATAIGWTVACGRLGVGCALFLSLLMNSGHEYVAPAIAGLLLFLSLLTLRILPPATTVECTKIASRETTFRDTQNIELMKATLETRLSERKKVKRAQDGSETGSKSSSTRSRRLKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3I9</accession>
    <name>A0A9D4Q3I9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3I9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="17629" checksum="170019A284373C21" modified="2023-05-03" version="1">MFRPSAPNSTSLEGSRLALTFALSARRGVIKVRVSSRRNVKAADLFSRMFLDDLVGVTVHCRIPVCARVPADRGFSTGYLHGVDGYTADDELFQSVESSLLMVSAAETADTHCRSCPTRSSEPLEGAVSVAPCQAAPIGMAEVWSPWPRNSHPQAPQMLPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q463</accession>
    <name>A0A9D4Q463_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q463"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="15739" checksum="455112284E44BB0B" modified="2023-05-03" version="1">MDINDAKEAARDPVPEDGDNTKPPETQEKSKDGVNNKVPDPTILKTDKKADSVRSGASGGGRGSRVPRRDVRKRGRHVTTATLKRARDETGEMDKTSSTNSEEPPAKTPQGRPFTLRPEPKISTDKRPADKTKQKNAGKQDGPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4R0</accession>
    <name>A0A9D4Q4R0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4R0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="143" mass="15033" checksum="ED4CA83846260910" modified="2023-05-03" version="1">MSMKRVTTIDLYMAIEMLQAAWMSVTASTIANCFRHASFGVNSGGDSEDIGAAANEGAAGDQDLASWDALLDAGVVPDCDTFCMYVSADADAVTTEELAVTGLVNDDSDECVDDSPELVKPMVDVRASAGCGRPAAPFLRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5G7</accession>
    <name>A0A9D4Q5G7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5G7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056521"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038691991" evidence="2">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="173" mass="18904" checksum="879FE471CAA4C2CA" modified="2023-05-03" version="1">MSPQKRNLRWLYLVVFASPLLIQRSTAYSVKSNCGKPQPRGKNCRPIPGKGRFPECCTKLLCQTGFSPSNMGSLTQQAKKILLESDGAPAMKRAAPEPVKQLARSAPRSASSSARSSDPRLINEVLRGNAVSRGRSGGELSRADEDLMESVRTVGLEPSDTEERREASEDTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5X2</accession>
    <name>A0A9D4Q5X2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5X2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18446" checksum="3018798F6F43EE9E" modified="2023-05-03" version="1">MVITDRSQTTVNVLSSRAQFFLHFLYRRRVFLVWLPLTVHSERPADTLAKQLQFPEDCGFSTDPSPASTHLCLRAFPSIVTSNLAKAIDEVKANQQLVANKLSEIEKRLATVETRANSVADIERELQVTNEAVGSIAQTNDVLVSRLNDLEDRARKCNLVFFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5Y4</accession>
    <name>A0A9D4Q5Y4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5Y4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028770"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29568" checksum="F1829E37362C0567" modified="2023-05-03" version="1">MQEHRCHASPDSPVSENIADDLDPPILTENAFGGRFGAGKSRPPSAMASTSRAHITNVMVEGIHHTLYTGDITIGTNTGSPAQIEERLQKAALLVDTYAASCGLECSPAKSALLSVSRLPPPQIFLPSGPIPAVKNIRILGLHLTSYLDPKGTIAGTSKLVSRTIRCVSTRRGGHRGTQSLRLAHVFVTSRVLYASPYLRLRRHHERQLDVLLRSVYKRALDLPIATSKSRFAALGVHNSIAELREAHRARQSDLPSGFNRPAGGSPASGSLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7Q0</accession>
    <name>A0A9D4Q7Q0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_022489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7Q0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032157"/>
    <dbReference type="OrthoDB" id="10062378at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005918">
        <property type="term" value="C:septate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035151">
        <property type="term" value="P:regulation of tube size, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF6">
        <property type="entry name" value="SINUOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7969894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="25571" checksum="32EA661BC5BE74B4" modified="2023-05-03" version="1">MGWSQLSLGRKAGYLFAALSLVLVFIAFTTPYWLASDPRVYSAQLLQLGLWETCFRSFADPRDLNMEKYYVGCRWIFAYEYNTLRDFIEIPFFVAVQVFFTIGFTLLLLACVLLLAMHICLPSARTLQLLKIVIALLVASAVCNTIAVITFGARGDGRDWMPDPDHNFLSWSFALGVIGAFCTYVSAVLFAVDSRRMARKLDEQEHQQQAFGMNPTHTMGAPPQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9A8</accession>
    <name>A0A9D4Q9A8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_013540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9A8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027400"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="15031" checksum="75F4532A7A837DDF" modified="2023-05-03" version="1">MISSQRLISRRHNVVPVVMGASREEYRAAAPYHSYIHVDDFASPKELAEYLRLLGSSPSLYNQYFEWKGTGEFVNTYFWCRLCAMLHAPPRPAERLRRTSFQEWWHDGACRSDYDVAKARSVRDSDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9B5</accession>
    <name>A0A9D4Q9B5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9B5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048771"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21049" checksum="955CBF8579AB97B3" modified="2023-05-03" version="1">MALFKHLPVFLELPGPPPIPWPNWKKLFQAHLEAAGASDWKGPLRASALVSLPRREGQRKYFAAAEQEEARTTPSNAASTTLRSSAASTPASETDSSAPAVSKFDTLVEQLDRLSAASINPLVERHEFTSRQLPGENFLDYVIVLKEKAVRCKFRLLYAERVRDQIIHGTSNPRVREKLLPHRKELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9M9</accession>
    <name>A0A9D4Q9M9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9M9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056310"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="22264" checksum="64C4EA8432824D22" modified="2023-05-03" version="1">MATGLGWELVLPKQDDNVVVADNFFTGPHLVEALSRMGISYIGTVRENRISCSKLMDEKSMKKRGRGTCDTSVISCDQKTMVAVKWHDNRTVTLLSNCIGADPVTSVKRWDSKEKKHIFVGCPAIIPAYNRSMGGGILQQHKSPPTHLREFLSELATSLSLLNKRPPGRPSVQNVTPLKKVCLNVRRDVRRDSKEHWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA57</accession>
    <name>A0A9D4QA57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA57"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14377" checksum="12D880E133CC122A" modified="2023-05-03" version="1">MEYVVEGQEVVSRRTHRTVTGSNQAFEPRRSNSVRHYAPPLPPKLRPPPCQPPATTIVRNQADQCFSDTGLARRFPRLPADTIHVVGRPSTSSTLMSFSLGTYTPPYCKQRTCNISRRHPVTRCGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA82</accession>
    <name>A0A9D4QA82_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA82"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9663" checksum="71420A9D95557223" modified="2023-05-03" version="1">MVLRAQESELVKYYPIEYNVDRQGKSNICRGEREELYKKIAFVYPLLEAEEGVAEDRAVNNPPCCLGREGGSNPGGHPGGGALSGTGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAF8</accession>
    <name>A0A9D4QAF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_009895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAF8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052883"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="327"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="679" mass="73712" checksum="BA675F42A2B7C492" modified="2023-05-03" version="1">MWPSFFVRLREQLGAMPAAKKQNDKNVNWKQACRNRCSVRLLLGYAAPLLLTPAAVVNSDMVWCLSLGLLIVTWTLLGTVPVPLTWLLPFFVLPLAGVTSISDLSHMFMEDSLVILLLGMNALVALGEETALCSRVALYVIEAFGLRLRGILLGITGVTFLSAQLLMGGSATLLMCAVVEATMFELQHDIIAATIAHGKRRNVRTTVGDDVVMTPVHVMIISPRKTPSSGSSADDDDEDFDEMDESSEDDEEDLRPRVLVPSIAPFDARNPGAYYQLHGSVPDDPRYIVSMDAVIPEIEQNEDPNAPKKSPILRHRNTAKVFLLEAHRFHKIKKALLINVAHTSAVGCMATILGSTSGLYLRDYFHFTYGYDAVTALSWTLLGLPVATVSVLLCAFITYFLFLRSYDIQEDNDTLNVITEIIRKKRKFLGKLTCKERILVAALGLLFVCCITISGVSSLFGLQEQLSIKYAHESVNVMVVVVLLSFLPHGPRKGSVFDWNKVFGRLSWRALLSVGGGLSLAGAVESTGLSRRITENLSSLDFLTPLQTQVVLILLTTLLAEVNTNVVIARFLIPIASDIGVLTNVHPLYYALPVAMASCTPTVLPTTAPSIAVVTSSMDIQIVDILYPGLAVKLSSILLVLATVNTVGVSLFSLSDLPAWAVAKNGIMAGTLTNASGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBC5</accession>
    <name>A0A9D4QBC5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBC5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035186"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="25237" checksum="FF63FD7522D40F9D" modified="2023-05-03" version="1">MEFERLYAIGKDLGMTGAELKRWVDAEIARERDQRAQNREDAKAQAEQDRLRLEAEERVLKLKIELQEKTGSTQGAATDSSAGQALARAAPDIFSPHKLIPPFNEERDDLDAYLKRFERVATSQDWARTKWALSLSLCLTGEALTVIGRLDSNAATDYDQLKATLHQRFRYTAEGYREKFRNARPEDNETAMQYAGRISGYFDHWIEMSQTDKSLTPFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBS9</accession>
    <name>A0A9D4QBS9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBS9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056395"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF1">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="400" mass="45531" checksum="AC7287C0959C924B" modified="2023-05-03" version="1">MEGPETRHLGGSTGGLSDGVPPPPPMYVPLLEMRGGARTRAGPAAPVYSVPVAVPITKAPLDGQLGHELKARGCLTWSPESSPVQDEHRPKSFYDTDGPTGYSYDIIPDIVHLVRYNQKEISFIDVISFRSIYINHRPKKIYVHCSPCGFTGAYTRLLEGINFTFIATTFPKEIFNISIQERYHSTDVVRLRALMRYGGIYADRDVFVVQSLRRYLRYEATISCHPDGVFGNMLMIFHKNSRFLRLYYDTYHQLNDSIWYYNAGVVPTEALVHPHPHLVNHVRYGLETEVDMLHTLYEPHAYPHWRSAYAVHTLYFHRWESKHDPLHNAELNETTIRDLDTAMGEMARSVIFGTSDFVPPDAPVLSVAALAARKDRGENLTRIRSGNERSFFQPVLRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCS5</accession>
    <name>A0A9D4QCS5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCS5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056465"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="336"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7975992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="617" mass="66439" checksum="6FA76E1C3A6E4686" modified="2023-05-03" version="1">MNDPPNTRRAAAASSPGTCFWALRRSLATLDSESSDRERSVLSRGVATRTSAVNGMAGDTYGSVASTAVTARKKRRRSINKADSISPEAAAGGGSTSSDEKTPLSQGGPPPLPTSMRCRLPSGSPSSCLSDDELLDPFCPPSKKGTVGFFSCGLGGCRKIKEAGHIFMKSFLVVALLAAVVLMGIFPEADEDTKGSKFNVTSGSGSHRIHLDDWQSPVQLSLRGPFLHRSLANMTDVFTTVTLVTDTNGTSSGSLSKLSQIMRIPTATTADAIAEISFVVKEEFIVTEYQTTPDLLVEVHGSPPDVSYPLQSLLEPSEVEFGLSVFLAASVLTVLYLLIVFELVHRTLAALIGATMAVGSLCLVGQRPSLAQVVSWLDVETLCLLFGMMILVGVLCETGFFDYAAVLAYRLAHGNIWPMVTMLCTFTAVISAFLDNVTTILLMTPVTIKLCEVMDLDPKNVLIILVVFSNIGGAATPVGDPPNVIIISNASVRSLGVSFTMFTAHMVPGVLLCALGAYIYLRVFYRDVNKLRLAQCSDYLEMAHEIQVWQKAVFSLAEYSRDETHVRHVLRKKVRKLVRQQSKRSHYARSATLPPPPSAIADRTPAGGKTASYMEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDD1</accession>
    <name>A0A9D4QDD1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDD1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042647"/>
    <dbReference type="OMA" id="TKEFLFM"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7975906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="465" mass="53184" checksum="68DEDD862D9B451E" modified="2023-05-03" version="1">MPGGKRKKFIDKKNAVTFQLVHRSQKDPLQADETAPKHVLLEKRTGRPFTGDDRPGHVPASDEKRKEEQRKYGIYFDDDYNYLQHLKDVNTVADWEPVIHRVRIPAGQSGEAKAKKEIRLPSSVFQSTVEEKEGLLNKAVPQVGPRPDWDPDVVAALDDDFDFEDDENILEDDFIQLAEGPVDATDVDVEDSDSCDDEEEDFETDEGSEERFSFAEEETQSRFTSYSMSSSVIRRTEGLKTLDERFEEMFKQYDDLEVGALDGEEIEGYVQPDSEIMKALVKDFQHMKQLPTLKEVTLDKGCARSAVTMAAIEEEDDEMVDLQISADAPKERWDCESIISTYSNLYNHPKLITEPKKEKVKVSARTGIPIIEKGGLSRQGLKQLDREFEGNSDEETRSRTSVASSIRPKDETPEQRKERKAAVRAMRRERRAEKKANSEAFKAEMLRQEKAMANVRQNLNSMRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE01</accession>
    <name>A0A9D4QE01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE01"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20398" checksum="E5D32FC649AD94C1" modified="2023-05-03" version="1">MVSEIVRSGRLAAAHKFDVDEKYVRCWCTQMHDLAEATRTRKALRGTKCKLPKLGEDLFAGHLTDREKARLAYCRMDSAVIPGGLTGVLHLCINRPFNAEFQRCYTETPTGRLKRASLQQVCIWIMGAWRSFSVDTIAKSFQVTGLSNAMDGTTEDQLWERADEVSSSDSGESAVELNSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGD7</accession>
    <name>A0A9D4QGD7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_010384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGD7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053176"/>
    <dbReference type="OMA" id="HEADKRY"/>
    <dbReference type="OrthoDB" id="6429687at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF43">
        <property type="entry name" value="ZINC FINGER PROTEIN 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7976253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="20071" checksum="961A3B3AEEA715FE" modified="2023-05-03" version="1">MGFIVDICKKEPDCVEESSCDNAPSRENSRLLYCHLCPHTAKTQRCLKDHLLVHSGEKKYECSICAQRFTYLRNLRRHMPSHTAEKRYRCRRCSYDTTDKNAYNRHIVHHEADKRYACSMCSYATSRCSDMVKHLRIHTGDRPFKCIKCSYATASKSTLTRHARTQHEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGM0</accession>
    <name>A0A9D4QGM0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGM0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041682"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="546" mass="61063" checksum="3095176379086CB7" modified="2023-05-03" version="1">MDASGKLPEGLLEGRMASIGSYDECLDLVAEYKTQELYRGKYCTVFLSSGHNVQEMFNNETDASAHLSTLLRHPKRMTRIVYRVSPQSRKFRLGVCVPSVCTLDDVQNVVAHSCLTNCLLSFSFARNLRRLTDPVEPPELGAAQGVQAISMAWLICGHTYFLTENTHMFISAAYQEYAQSGLFLAYKCELYSYKSVFSILLQKYFRNAKIGYSSVLGFALAGCVVTGAITFAKDLPPGSIFEPNYREVERLSTWIYHKPYTHLGSFCVGLGLGCLLSQFDKNRLSKLAYAMGWVASLTTTSVLFHCGFGWSLERASPAGASLYAALHRTLWALAVAWVLYACCTLHARLLNEWLSWGPLKVVGRLSYCMLLVHPLVIVSQKSQNRHITFFSHFDMMHLFFGHYAVTLVLSFLVHLGVEEPFAQLGELLGSCEVTCPPRLKQLTQNLYAGVATQLRRRERQQQQQQQQQQQAVSNRKEPSEGAKKAQQPSQQQQLDNHHTEIAIDVDVGRQLENGTEVAVIKENGRDTSHVVRDGHRDSAGSPEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGX4</accession>
    <name>A0A9D4QGX4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033908"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="534" mass="59292" checksum="DC217D92D622F739" modified="2023-05-03" version="1">MSTGAAPICASKRKFVVRAKPSSGSTNSSPVELPSRREVNLPELFAHPEMHTRSDDPAGTTEEASSKLKSNDEIQAIPERTAPSHKFEAELASHSFSTVEESEREDGTRPFEYATILNSEDDATVVEKSHWRALRQSEVADIEKKLRRILQVHGPSDQDELLKALSPSQSQDVLRLYGTLTAFIEQLPGFVLVHEDLYTFVYYEEPDDEEYDRGRSSDLQDEADAGACSTASDNGGLQRTASDDCELQRPRSSSSSSSCYESAVEEQPEGEEKHGLKDASCQVSSSPCCHSRGIQAVQETSDAETQTNVLDTSRSLELKSTPQGAGADVTQMKEGQENLRQNQVGEVQQLTTEQLLKSPQAETPPYVVKLNNRTATKEQKAVDKNRAGDEVSPPQPRLPLRQRNLPPRLRPGNKLLMPQVEPRSWPLEQFDEQFSRPAKPLFHEVPDSEKAATASTDVEYTRSSQRETAKGKTHKQISKIVRIVKKQQPELADHEIRVKIDRLRRSVGGLSGMTFSAIVELLLGKAKAEPEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGZ9</accession>
    <name>A0A9D4QGZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGZ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="170" mass="17916" checksum="6CA6FFAB534C3F61" modified="2023-05-03" version="1">MVWGRQSSLGARVAIAAIATDHECFVGRVHFLLQGGLKVDLLGAIQMVTGAWRDVKTDTVANCFRKAGFVTAELADTSEDGDDKRIDDAFHELSSFFPAAVPPEVSAGDFEEADCNVQAVASVADEDIVAAVAGTQDAEADSSSGGSVRLGSPFLRRHGVNWVVAPGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIP4</accession>
    <name>A0A9D4QIP4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_006470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIP4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055417"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="303"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="835"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7982660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="931" mass="103780" checksum="A56B7770A42B7E1F" modified="2023-05-03" version="1">MFPYTNQKLLRSRSPSGQNSPRLRRIYPSRIPLWSSPSYSPTSFPRRLPGRGSGRSTRSPSRNQGEYRRPGGRSPSRPSVTGADKRSGASSPAIAPVHEDPKPAGSDAAAAPSTSGTSKVESSAGSPGPSGQTTPAAAQVTPSSTDKRGREHGAGGSGATSTADKGLPTDPSTCSSSPEAGHGRGRCPAACSKRRRIVIGKLVDFERRISRVPFMQTARAASLPLTLSPRGRRHTKDKDSGTAIATAATMIVLVTLLTLLFFLMPSKSRSQEQMQGRETLCRTVGCRYYAEILAGAVNATINPCDDFEAYACSNWAPLAHPYSYGTASMSSAMAAWYESFRNIFLDGSRREHFFRKVDAAFASCMLTSPEDSRRGISELKAFMRQLRISWPDAPLAKVDPLGVLLDLSLNWRLDIWFSAALHRCPYGCAPSGGGRHILFDPTSFFTVRVKMQRDLSALKSYMTYWNRFSNAFFSPGFPERSEEYINRIAVIERSVFNRFILVGKKTAVQPVQFELGSIHYVTPNIPESRWIDQLNSNVNRFGDFHRNDRVTLWDRDLIYAVNEMFANYTRVELLEHIAWTFVQNFGPLADRELLLTQYGDKRAAAEYRHIFCATQVEIAYQRLFTSTYTRDHFTTRTRNGIDTLLASVAQSAVDKISSVAWADEASKQALVDHVRNVTVELWPGSEFLSDKSIDKFEQLLFADENDLFAQQWIWAMKTWRRLQDGPAYNDTVESPRNYALPYFKYTHVLNSVSISLAAFSRPWYYADGTKVMAYGTVGFSFARELARSFDPFTVPVDLFGRTALFQPATAWTAGSRRRASCLSPFHSTPFPEIPALEFTYQAYKDSVASTNDSERRVSSSISDEQLFFLSACFTMCNLPETMDSYRLRCNKAVSNFAPFAHAFGCQDGARMSPPIKCSYLDCTSTTICTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIR6</accession>
    <name>A0A9D4QIR6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050265"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038975990" description="Secreted protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8006" checksum="0D46F8F72D1AC3E1" modified="2023-05-03" version="1">MRGCRVVESTMRGQWPRALLLLVLVQPSLQGKLLKAALAAAANGGFRMLPVFLPIPVEESLYYPVHYFLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QLJ5</accession>
    <name>A0A9D4QLJ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_006921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QLJ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027937"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7982740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="290" mass="31467" checksum="AA4D4ECFF0EDB09A" modified="2023-05-03" version="1">MVDIDSSSPLSYEAIVRSHLLGFESGEHKWRGYVKTHQELEHRDQSGCSSHWRLECVAMRVDGNVVVVDWSGLAATTYANAAANTAAVGRTLALVMQRLVQEFPLSAALVHAIGYSFGAQVSGFFGRNLKKNTGTLIARITALDPAGPLFNETDVCVCPEDAAFVDVIHTSGGYKHQPWQLGLLRPTGHVDFYVNGAKNQPGCYGSTLCDHMRAPILFLESLVNKACRMVSRPCREGFAAFLRGKCGPADAGLDRGEMGFFSPRAIGRGIQLVSTGAGPLGYFCIKERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPB8</accession>
    <name>A0A9D4SPB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="519" mass="57316" checksum="3928F29F95919295" modified="2023-05-03" version="1">MATAMQVTVEGEDIGPAEISESAGWITAFSRRKSTSSRQTLQPCNVPRGANKGAAPASVRKQLTAASRLPRLPTEHFRVIVRPRGGLDIKKTGHFKIAQALIVAAGLTSGEVEEDVICPNMIQNIMVASTPSERNAKAYNTVASLIIDNVTYEVNAYMAAPNNTSKGVIRDIDPTLDQDELTRLIVQPRNPTVIGARRIKSTSSVIVLFDGLKVPEYVKCGPSLVKCSLYRRQTDICYACGRLGHRADVCPSPEDGICRGCGTSNPDDQHNCSPKCALCGGNHLTASRDCKRRFQVPYVVRQRRRARRYQKSQEAHDSTGAEPLPPKSATSRRSRSSETRGNRYRVLAEDNSPSPGRASSKDKGRSVSRGRKGYKPDSRSNGRSPSRSRSRSIGRSSSRSRKLSVSIQEPAEQGTGPTWADRVKGQTKKIPTTYRRSPNDNSCERPSILRKETPQRLWDLIVTAVHRQSSYGAAPAFLFPKMPPSHLSIPTQFEEQWSATRKRYCGRNSRNSGFVDYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPM0</accession>
    <name>A0A9D4SPM0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPM0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19565" checksum="1F47F1E44A106D0C" modified="2023-05-03" version="1">MTCTRFFHPESVDTNVLARELFFKPPRQKTPSTAWPPRQAYRQVGDAGSFAGDAGNADADGGPNCCAWRAVTIPPKKVWTFRSPILHIDKSTTRAPVMVTQLHDLQVSTQRNADDDDGGWTTALTVRQRKLQARERQQASRSVPGTDKQALFNNHRKPKYRKLPPLPRDDSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQG7</accession>
    <name>A0A9D4SQG7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQG7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044762"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14351" checksum="A9BC3109976269CE" modified="2023-05-03" version="1">MLAYSYSFTLLFIDLEPVEHWCASPEQFANLSEQLWKDTAIPRDSNGDFKQCERYDPLEAPALPLATSTFRPGGPVSDHLEASTQSPVTIDRTNASEVRVRASPMDLVPRAEMPSPAGTWSATGRGTRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRI9</accession>
    <name>A0A9D4SRI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045289"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7940267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63744" checksum="756465192A35707A" modified="2023-05-03" version="1">MDSVNAPEPLGPLQQLQLPTASLMASRTDEIATEHWNASSTMLRTRPAPEADAAAASAGSASSKPTQLTTTSSEDSMEHEDNNPSDWDTVHYRRYTTRRLKGELRLERVSRPHFFVLVRPLNQMSIQEIPKSAITRLIGQTAPTSVAAEHSAFKYIVKANAVRLSIWDKQHLHNLLAQGELTLTLGSVVEARRIPVEIVGATQPSEVTSKGVVKIRAEHTEEYIANHIRCESANILGFRIMGKTQMLLITFDTPRPPRRPSLDYEIVPVYEHRPRALACFRCHGLGHIAIFCPSQAVCRHCGRTHEEDSQCEETPFCVACQAAGHISLDPNCPTRAFRATSPPLPKKNAAAKSNQGEQPEPLDKNTGTPPKTWSQVTASNAGINNNNFEDRLERFEQVQAASTGAWNKFQQQMENFMQQKLDAMQQQITSWIQASQGIREQTAINSPSQVKPKKSDGPPLPKKPSPAAAEHTVQANPATQPRIEKHNELQRTPSTLDRKPSVTMDQALDTIMQLLEKLNSRMEAIERAMAQQEQVIMQHKEVNEREIAQIKATADECKRNYRRARNRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRY4</accession>
    <name>A0A9D4SRY4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045916"/>
    <dbReference type="OMA" id="CAFEAIY"/>
    <dbReference type="OrthoDB" id="6499695at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="312" mass="35919" checksum="CE6D20F3E4357026" modified="2023-05-03" version="1">MEQYSRRYERLLDSVVLRRRRRRRRAAQVLQSLRRFTEADGVVALASLKCDAPKLVQLEDFLDELALVLHNYLFSGNEHVVRVALDVVRSAVAKRCHRLKPCNLEHLLASLLRTLVSASSTTVFFMARMTIQDMLRAEPELSSAALSNILEHCEARQAIEIYMQLIAFVLVSEDILLSVLDRLVAITIRDLMRDSMAHRFCAFEAIYSLHYRYLSRRDLLTYAEQISLPKALVEALRRRLARRYVPPLKADTLKPEMMGDADFAWIAHGPQPSRTSPQGEEDGAERDVRFRRTSTPAPPAFPFEARRKRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSZ7</accession>
    <name>A0A9D4SSZ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSZ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055166"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="23211" checksum="F1AC9140D552FDF1" modified="2023-05-03" version="1">MTDAACHSGSAILTHSADGLDDVPRLAWTKGLRSLAVRAQRLDLVQRVQCQDRSLEAPLAWLTNCQPQGDWGSTNGLENGGWSYGPNEYLANVWGVPTSGYPDQWNFGNNNVGSGTTSGNFIGRNSGPGIGHGGVGNGISDVGSGNGGFGSATAGLANGNPGLASGVGDVGNSIGGIGSGGFGRESMGLAGGNTGFGSGDAGFISSGLGTGSAGFTSSNGVFGTGNITPGTARGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STA6</accession>
    <name>A0A9D4STA6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SEC63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STA6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026677"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF6">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="8">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7946798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16598" checksum="05972B5A71AEA039" modified="2023-05-03" version="1">METCTHSSALDGTRCPCSEMGDQYIKGPVADDRWLPVSAGSECMLQVQVSHRDPRHSARGGSIQALAPHYPKPKDESWFLVLGDREHKELIALKRTGSMRASCRHHLTFRAPQEAGRVIYTLFLLSDSYLGLDQQYPVYLNVQPAGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU67</accession>
    <name>A0A9D4SU67_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_008012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU67"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032015"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7951339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="409" mass="45274" checksum="80C6EFBCBF1CE491" modified="2023-05-03" version="1">MVQCCVPFCKSTPGPSNNYSFHEFPVTKVRFEWLRRIARKANGTGNKPWCPSDRSKVCSLHFREEDFRRDLKKRRLLPNAVPSIFPGYPPEMQQARRLSSPQMGDAPKVLETNSAIDKRIARPRRGRKRKCCGLRKHTTDSCATKAGSGVWDTFEEQLRCLGQTKHRWREETLQCCLLWNTLSPRGYRLISQSGLLSLPSCSTLKRHIGAVGNSTASNREPPSPTGDTLPSMEDIDDIHQLPDIVDVHVMEPSTDEVSDYASEVSVHSDTDDTARVDVSSETTVQDGSVANASPDLQAERSQCSTKDAASIVCPESGRKLKSVRDSQTRKKSLTRHFARVLAGNPTPQEGEQVLQVVYTKPSDILDDLPGVDSATPGAGDTTAAPESADELVEKSVVHKAKGRVGYRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV47</accession>
    <name>A0A9D4SV47_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_020602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050746"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="122"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7948332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="333" mass="38621" checksum="88F5CADA1A292F91" modified="2023-05-03" version="1">MLNTLEGVAQLVTLLVACAAVRWIRSYTLRLSVRRASAALTVAFLFLVCYYVTHLEKQGITNRRRFVAYTPQEFADHVADDVKVIQRYFWIAARKPSKYGNYRRLNWVSHQLLTANRDLPGSANRNWSFVIVRSMTPSAFVLPNCRSYFFEGLFRLCENDDTLSFVVAHEMAHCLLDHTLEKESLAYFLDRLNTLVWISSLALIRGTVKATLTPWFVSRALHYAVFLPHSRSMELEADSLALRMMSKACFDYRYSIVYFDNAMMLRKRVMGTKKTRKVFSTHPTRRERVNALYGQMNSALALRKSRSCPPLLPMRKNDEIKFATFLNLTVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWB9</accession>
    <name>A0A9D4SWB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052645"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="29"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="496" mass="55109" checksum="44C4AE0C7C80F196" modified="2023-05-03" version="1">MKKLPLVKLGHAPRPQHFSRPLLPLDQVFIKIDSGSVQGTIVTTSEGVSVRAFLGIPFGESTEGRNRFRKPIPVRAWNGTLNATKARTPCVQESYLSQAMRIDNANTTEDCLHLNIWAPIQQHPGEPKKAVMVYFYGGSFTHGGNSYFFYDGRYISSIGDVVLVVPNYRLGALGFLNAGTPDAPGNVALHDQILALSWVKDNIAAFDGDPNRVVLFGQSAGAISVSFLQISPLTRHLYRRVILQSCSALVPLPENSRDVAFANMRHIASATNCTRAFPNGNLSAVDTVSCLRTVDAKVLVDVKGAFFYPSFYDEVLPQPPIELLKSMDFRDHEMLIGNTLREGDMFFEAMFGQKKRSSTTPGGSRLSLDAIAKAYDFFYKRTGFVKALFTLAQIQRLYDFTSKTYEGFKDAVGDLLFNCPTKFFAKYFVEQNGSAFYYVLTPRPSFSAWNSTAATHTDDVSILFGLPFILPGKASDAERYLSRRLIRIWTTFAKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYE9</accession>
    <name>A0A9D4SYE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYE9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="361" mass="39842" checksum="C3B6DCC93E77E5C0" modified="2023-05-03" version="1">MASTGPQDEPTSMQTEVNAETPATASAWTYDVNSGKTIGKEHIEWLQVGRKAKRASEPIQASKEQPEKEHMPTQKPSKQRNLKMPPFPTDDFKIVYRPQAGLDLSKWSLTAITHAIGRSSGLTQQDFYDNVRVQMQSVENIIIASTADTERATELRSITAIQLGGTIFSVNTHVRHPDDVCRGVIYGLLPGTSSAEIVAGLRVDSRYTVLGARMLGRPSTAVITFDGPHVAYYVTYQSGDYRCKPYRKPREDFCYKCGQGAVTEDHDCLPKCKICGQAHENAEKECKKKLRPNPPPYQVRQQQLDKAKPERMAVVHVARTSPSWTNPVAAPAAHNEASPAEAGLGLSCGRAPRLEQARQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ07</accession>
    <name>A0A9D4SZ07_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_012869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ07"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045478"/>
    <dbReference type="OMA" id="EYRVFEM"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039479989" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7961859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="338" mass="37483" checksum="335E34397396E2CE" modified="2023-05-03" version="1">MKVLVVFALFAVAAQGRVMVPSSVKPLSDEMINFINNLNTTWKAGRNFDENIPFSYIKGLMGVHPDSKNYRLPLHYHGEIPNDLPESFDAREKWSHCSSIHLIRDQSTCGSCWAFGAAEAMSDRICIHTKGKVQVNISAEDLLTCCDSCGDGCNGGYPAAAWQFYKEEGLVTGGLYGTDDGCQPYHFPPCEHHTKGPLPPCKGDGPTPECVRDCREGYEKSYSEDKHYGKKVYTLSGDETQIKTEIFKNGPVEADFTVYADFLSYKSGVYQQHSGEALGGHAIRILGWGSENGVPYWLVANSWNPDWGDKGYFKIRRGNDECGIEDDINAGIPKELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ16</accession>
    <name>A0A9D4SZ16_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ16"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055128"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="22830" checksum="504D6127A7809D03" modified="2023-05-03" version="1">MADDLPPGFPPCYSLSGDLNHSKTYELLMKEAANLVREQATQEPWRLSPPRISPVRTNRTRARQLKDAASLLRKDTMPVSRTRTRKASRTPAAPKNAPQPGKARKGEASSMTAPPTTPSSLSGKSAQQTTAAIFSPPASSQTHPESQQRSPQNPLLEPIGSSNREECCTQHDKITFAPSQQESETNSRGSPPPQTGVTRGCLRMRWCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2C3</accession>
    <name>A0A9D4T2C3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2C3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040551"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="16029" checksum="A2BD39179B61B87B" modified="2023-05-03" version="1">MWAARHSLTRRWKRQRHNKKLVNCIAFLSKRITEYTAELCRETWLSTCDGLQGKLSAQKTWCLLRHLIDPLSSKTATSGNLTKVLNTYKGDGRRLLEELKAKYLKTERGQLPTPERVPSVARQPIAIPFSSEVSSPLLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T416</accession>
    <name>A0A9D4T416_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T416"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029246"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7969302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="10081" checksum="4E65E616A9BB28B0" modified="2023-05-03" version="1">MKNGTFSIIAPTTATSYATLASYANTFRMPFVSPAFPQITDVRPALYGISLRPRYLPAIVEVIKHYRWKSILYLYDSDDVHKSSRHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T458</accession>
    <name>A0A9D4T458_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T458"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="942" mass="104250" checksum="169BD1878438214A" modified="2023-05-03" version="1">MCAVSMANASARRDDGYGGSVSEENAYRFRPANVDGYMHAFKQPSAPALRYVLDIAKERITYNRSLVSRKDEASRSAKEARILPKTPQRFYATAAVSSLPKLGTRHLRSFQGDTPGIAPWSFPTSMAATKFGVFPARVFAAGTSRVVKNLSAMKGNDVIFRRTYSRTTESWKFGYKGHAAVITGPRAPDRLRRRESIRYASLDQNDLSTSDEKRSKNRRRRVHRTAMCLLVACSILMAITVCLVIAALWLRSRYRSQGTALYSTLEVSDPDLPAYLPADGPLYRPASPQLTEDDLSFRREGENAELPRKLAGQSISAPVMWTSKAADHSPDGREKVVPSVTAASPEPISFLPQMQSAPASEFDVSKTTLSPVASEPESITHYAEKKRKSLHMQPSKLVLPQRSFSASRSDVDQTFGAESRFCSDDAVTPDPYPAKLEDRDLATAKANCEVITSKVALTRKDRLSEPTVAGLPDVTTVKGDACRAKGEQNTCELRRPYVSTSSTEQTSSIPEIYPRNSDSDDFRIGLDTSPLPLPTIIRRSLTKTTRRWGTAGADTTATSTTHTSSCEPRPQRKKPALLLTPPPQSSSTDSFESLAITKHNERPSEADCCYQAINTGLWFPLLALCKRSKPVDFLHVIQEDCQGTKLSWAEPGSGDVFHVLGSRGDRLVRVLRLRESDIPWHTSRLRVSRELSNLKDSVDNRTSAFFVGARTSLVRDKYARLLSNARMQYDDQFILRSATTSAEEPELVADYLVTEMQPGWCPLPNYKLTDPEQALSVLSQACWALAVAEAELEFEHRLPVAGAVLVRPTCSPRVEFTLRGHIVRIPSAGLKVRLQGLQLARIRIGTRVELTDFERFREFVKAEHEATMCAQIADLLSKRPTKFEPLTNVLWLQHLADWLASQYADAAPALSHWQGVLAASCSAEHATVGSRRSRSPSGTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T553</accession>
    <name>A0A9D4T553_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T553"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7971820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11590" checksum="28AC756CCD319DC1" modified="2023-05-03" version="1">MLAIIGECRTEQCGACDSYKQNRAAGEYRGSARISAGFGGVFLEARLRKRVVVLAGTSPSVPRTTVRWAQAIAGDSDSDGSERLLNELGAQIYDFNARHGLRLCRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5A8</accession>
    <name>A0A9D4T5A8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5A8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029187"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="633"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7971864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119786" checksum="5272848000665D42" modified="2023-05-03" version="1">MGRKADRKAGSGSSSQEWVFCVSCEVWVDLECTPFETVEEARAAPAFTCRQCEKIDTVKAEMAALVKQQADDSKLLIANLEARFEREINAYRSECEALRVTLQKEREDKEGSTTECEALRQALQQEEKLREILRDEIAALRLAFEEMTACRPAAAPSGTAEAPRGDGTASHEDGAANASSSGGTVKAAGEPEKTPPTHRGGTGNVRTKPKTRAKRRPGTNCAQAQTAKSDVVRGGHEETSLQGREEQDLAGPKDQVTPGAALKRHLEKLGASAQQDRRAFVYGDGNAARLKRAALKAVGWNKRVMFRVKEGASLQELCSSVDLAEDIWQTPAAIVVLHAGSLEMSDGSSAPESSASQLRALLTKWLQKAQGHRFVVYALTERGSGSETHINPCREWNVAVRKMCEELGPRVEFVGASWRLGHGQQGPSYQDDTADQLGQRLGRRLCAFLGLRMPTRHWGPPSQSHPAAGTLMTALGQAIIQMAEGQHPHENGRRRSQGGPHRHTRKRRRCRRKGKQDMVFYLNLQGGRKEAKWEELFLLLQKENVTVACLTETHLRDEETPPPNRQFVWSGLNRTKGERKGGGLGFLTKVDTQWDRVQRDCKEHMWLTGEIGGIEIALGLVYLWTGREVHQRNTETLACLEKDITQMNRPVVVVGDFNAHIEALDGTTDRAGRLLLEWTERLGLTLLNATEKCMGRITWAVRGMSSCIDYCFLSPVLLPKLSYMSIDSTGERSLGSDHHSIFLSFGTNPPETKRDAHAGNLRPLSDEALERVVDQLEEDAPRMEGQGYEELQQWIRRTIQDEAGAGRVTRGRHRRKAWWDGEVAEALAQRKQCCRRHRHALGRGADEAELSALWSLYLEAKKEMASMVQRKMSTRDTRKKVRESVSAVETERWRESGRAKRALALYWEAKTDIAKEALYDNSRGSGLLCEARSGVLRTRSLRARYTAELDTMCPLCQGAEETIRHIVLECTGLRPAIHDAQDSGTSAQGATGATNDSSALARALGFRGSGEPPSWEAVEATKRRLECCPQSYDDICAAVLACYGEPCRPLPASRVFQAFSLRRRERYQLARAPPLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5B8</accession>
    <name>A0A9D4T5B8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5B8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050296"/>
    <dbReference type="OMA" id="AGTEMHD"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7971894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="36265" checksum="A5F63094986B7320" modified="2023-05-03" version="1">MVAGNADRCRDPAAGPVNYEADPVYVDGVAFLPLSDVRLAREALSYEPRPGDVILATFPKSGTTWCQYIIWGIHNLGAVEQGLMPPVQDVLTKHFPYIDLLGTSSTVAERPPPRFIKSHLPAELLHRPSGVKYVVCLRNPFDVAVSYFHMRFGRRHLTHLPPDYGFDHFLDELLSGGIVGGNPFQHARAWYERSKDHDNVLVVYYEILKKEPRKAVLQLAKFLNPDAAARLETERGLLERLLEQTSIQRLRELAGAAENFAEGDFSRQHPTAALFRKGIVGDWRSLFDRDQERRFREAYDRALAGTEMHHLWAEHVATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T657</accession>
    <name>A0A9D4T657_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T657"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="13573" checksum="33FCF6C468B8F123" modified="2023-05-03" version="1">MKSCAIREGLNAADPQVDSRDECAGDELFKSLGTPVARLQEKRESGIVLPHSEGLCALSLTDWNACLPATLFSLLSVPYETTGPVLVPTFGSKYASFGFRIMDLVLEGNQGYATTYLVETAAFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6M3</accession>
    <name>A0A9D4T6M3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acid sphingomyelinase-like phosphodiesterase 3b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_000631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6M3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038381"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038516926" description="Acid sphingomyelinase-like phosphodiesterase 3b" evidence="7">
        <location>
            <begin position="24"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="9">
        <location>
            <begin position="313"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7975370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55050" checksum="2381264099884660" modified="2023-05-03" version="1">MGMFTRLISFALILLSHALSVAGSRDDIGYFWHVSDFHVDKQYEAGGSRDLYCHPGTNDSTGDDTGPYGDFFCDTPQLLARSAVEAMERIKPEVDFVLWTGDNVAHGKWPTWTDVYSQTHWIGSLLWHKIGQNRTLIVPTLGNHDWVPANAMGSMDATPYRGFLRSSGFNQLLPEETWGAFERGGYYSLQLSKNIRLVCLNTVLWYTLNKGVRSSSRGDPQLKWLREQLHDAQRQGQKVFISGHIGPGFFIRTLPGETARILFFDDINDGYQDLIGDYKDVVAGQFFGHQHANAFVLLSDKAGNSHPLYKFTSVSSNPSLRLYSYRRSNGMLLDYTIYYLDLQDANMAASSKRVPRWERLFSSKDDFGLQDLSTASMVELAQRISRSPDLLSRYISYSTSLRDAGPCDGVCRETMLCAIMASRRESHAACLGRGAKGHSAHGLPMKDGTEPLPTIRDVIVGLSVSASVVAGIVLLALAKRARMMQGPRYGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6M8</accession>
    <name>A0A9D4T6M8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6M8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032635"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9264" checksum="D3FFEC41EABB3B62" modified="2023-05-03" version="1">MVRCIDPAEFQVLGLSADLRSMRDSPTSSVSSLHSLSGTTAALVVSAVPKPSAPSLTPSLANYYNESLIEHVTGWQADHAERQVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7J9</accession>
    <name>A0A9D4T7J9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7J9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029539"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7976389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11423" checksum="72ADF5EFF41C3AAE" modified="2023-05-03" version="1">MDVPHRFRVHNYMSPTFCDHCGSLLYGLFRQGLKCQHIHGVQLRRMFSALSGVRRFTFAFRDSACVLRPGKLQFAPLAGFRVARRRDRKSGAAKTAVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7L5</accession>
    <name>A0A9D4T7L5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Schlafen AlbA-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7L5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040381"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF47">
        <property type="entry name" value="SCHLAFEN ALBA-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="105542" checksum="E6D9BFBE269F1586" modified="2023-05-03" version="1">MIGEHGTKLLQQRALLFCVGVWRSDSWEQSVQLPWTPLLPVSGASCTSDRLGEHVGESNPNDGEEVQANAQINVEARGEVAPANIETDAEDVPAVQPRDSRRSGSQAHSSSEDSCSDESSSTFNEEALRAEDHQRPSLRIADVGVFPDKASGAVPKRSAEIQQWTTQRTPKFETIYEMTRKFVHNFTTLHVEREYDIHDVYVCVACSSAQRMLVQIREAITEDQEGRRVALDNATFMNVLVQLCNLDSSHVPRICAVGSREIRTYYQTASCCKIVGTVTLLEDEHSEQLWKRFFGAAANKISTKTYTVKVQGNPRTDGGGYGDVDAFLEQATKRSQLAVDWTGDPPAEADSLIIADCLDARHVMVYDSLKAKEDAAALDVSIAQFHQLSLNRETLREPPNVGDIVGLVVAKDCVQRVLVVKVIEDIGVVWSIDHGRFHKVQWCDLINVAPSLWSLPPAVALAVLQDVEAAPYAKLLRECVRTLRAVTNHDTNEETFHVFMLTKVTTFGVLDVLSDLLHCPDYVTRMTAAECLIKICCRHNGRQAVAKAACVPQALLRLDDLTRSEVDDDSSVAMVTEEMRALFNLLQAMFFCNEQLRLECAETDLLAIVVRAHKSLPPTDTIRQDAERCIRAILGVPPIRRTAEQQKLKRQRKQQQQAQPRDCNRQELHGGYRQDPGTSSDACCPTQRVYKRETAAPAQVRLVTMTPEKVKIATALSCYPKSEALQPMDAAAASSLMPTQIPKPMADVPPSSACTGGAAAAAPRGRFYIRGMLVPLRSDGTREVRPVERIKKASARTLANIACSFLNTWKPCSIYYGISPEGFVRGVMLNQKERDDLRCGVDFTVGNLRPHLTSTSFGVEYVPVLRHAADKPEEAHHFVVEVWVRGVHGIVYTTSDGDCYLREGGVSYQAGTHDVRAWIARVEEKYYLQANNTASLKEGALPAAGDAPWHDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8E7</accession>
    <name>A0A9D4T8E7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8E7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035297"/>
    <dbReference type="OMA" id="EICVDAY"/>
    <dbReference type="OrthoDB" id="6485531at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="177" mass="18713" checksum="B329CB273BD715A3" modified="2023-05-03" version="1">MSTEAGQQIPGRRALMPGWMKSHMDRLNTVANLDDMCSSPPETESGFLRDMPLTRITTPPASQTPAGAPTIRVSGVGKCDLPRLASEDALRHQVLSHHGPSLQSLGRDSGSGSESAHTTPSATPQSSPSLVRRVVAADLTAVGVPVVDGSRLKPKKKPPARFAVTNFDLNAVSPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8Y1</accession>
    <name>A0A9D4T8Y1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_007297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin Y subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8Y1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028395"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000011">
        <property type="entry name" value="Cyclin-Y isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7982817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="305" mass="35049" checksum="9711309D990FBA6B" modified="2023-05-03" version="1">MGGSLSCCSAPSPRPHRNKKDSADPPHSEESASNLQHISEREPEDCKEKRRSQINLQEKAPLKKSNSCSTIYLDDSTVSQPNLRCTIKCVTLAIYYHIRDRGGQQRTIDIFDERLHPLSKEPPEMRDPDHRTIYRFVRTLFNAAQLSAECAIITLVYLERLLTYAEMDISPCSWRRVVLGAVLLASKVWDDQAVWNVDYCQILKEITVEDMNELERQFLELLQFNINVPASVYAKYYFDLRTLADHNELAFPSEPLSKERAQKLEAMSRVCEDKLGELHRNGFKKWSSLDNVNNVSVRRSTAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA65</accession>
    <name>A0A9D4TA65_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044398"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="21348" checksum="159E5408E5005737" modified="2023-05-03" version="1">MERDEFQITKALGDIKVHQAELDYTKFEPRIPDVSEEEYGHVLEMYDFPAEFETKDLVTALSSCRDQFNIKWVDDTHALAIFSTPFAATEALSLQNSLMKMRHVSEASKQSKLKIKHCSEFLMPYKPRPQTSASVARRLVSGALGMRVKVDVEQRRKELQILKEAKGKEKENTIVITSKKISAALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAE4</accession>
    <name>A0A9D4TAE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054924"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7983748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="203" mass="23502" checksum="0A7677C60AEB6A0E" modified="2023-05-03" version="1">MGEATQVSSLPLPPMQYVGLYTDENVQRGRAPSPPRPLHEGYSMFGAPFHGDEPVIRPLESQGIRRLYPQNYEHKKELKKLNHSLLVNFLDMVDILIRCPDTSKRIEKKEDMSLLFIHMHHLINEYRPHQARETLRVLLDMQRRQRLDTAHRFHKHLDKAPCTPLKGPLTDLDIEDELARCVDSAMAVVCARYFASVCHIEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAF1</accession>
    <name>A0A9D4TAF1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_014688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049567"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="7">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="6">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7983840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="228" mass="24333" checksum="0FA63293B96E8E0F" modified="2023-05-03" version="1">MREQQDEAGLSLGQARRLIEAIRKIKSQKQRPSLERISHALGLGTDAVERQLEQAIAKGFVLKVMNKGQCTYKDAETLKLTTKKKCATTSSVSSVAGNAPGRARAAAVAAAAAIGAGIHRRTDLMHSAVEAVRALGEKGGSTFRAIVKFVRQALRLDPGVRLRLAVKRAVTAGRLVRVGRLYRLPGSESDESESDSDDELDASDRLGVGKNGDIAGRTGHKAHGSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB97</accession>
    <name>A0A9D4TB97_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB97"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043282"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25741" checksum="746B02AA5BB54D24" modified="2023-05-03" version="1">MGSAEQPLGNAAAIRQLKGWGAVGGHNFVTSGWVSEPRMKQVAADSGIIMTQACSHIAALLFYVEYGLRAREERSCTDGSKSWFPPTMKKLEVRPVAAMGLSSSAMKKWRIDTATSQLVHRSLDRDQFLGVLIAAEYRPAVASTYVSSVRSSKAMRSKDFSVTLTQEPHFDGRLDAGLRMVVAANGLPSSELLSRYKTRPQDHKFANVGGIDEWSQIHIHYAFACLQREQVHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCS8</accession>
    <name>A0A9D4TCS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_025563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000847">
        <property type="protein sequence ID" value="KAH7985564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052207"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7985564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="677" mass="75621" checksum="9A2C5FE09EF0A7C0" modified="2023-05-03" version="1">MVSGLLTLAVHKRGGSAVADAPGVPSEPRCGDPTAMEVTVEGTEITPEEFRAAEWITKVGRHVKELQDSARDDRHGRQNGNARTEQDEDGGGERRIQKLGHKIAERSVASYLPRLPANDYKIIIRPKSGLALAKVPNTRLSAAVRMAAQIPWVKGQEKEVLIVNDKQGTLIFSTPDMDTVWKDSGRGVVRGIDPRLTIEELTEAFGNPRNPPILGVRKLGNSSSAVIIFKNETVPRWMYCYGVPLKCVLYKKRYEVCYRCGELGHRSDVCISDQVHCRGCGMTAPPEDHACEPKCKLSGKGHLTADRKCKEAFRTPYTMKKRQWEAWRRMEEEERKTRRLKSKRADWKRIKEGPGAGRNTGAGREGGQEGEQPPLTGPVTEGTSGGAVLNSGRPTSPIRKKPNVEVLEEQSAAPPPAKKRAKEVEKPVIDKNIEAVIDMKIAKLEANFEAKSTQDDEWRKAFEKRMLGFTRKRAVLQEFLRKGDRPEVIALQECGKKATLPGYKSYVSEGASTQVATLVRRNVTAVQHDIGNAHVDHVLIELIPRKKKDGSLFILNIYSSPRQRRCDFGDLFATTRRKTRNNPLLIVGDLTLTTRHGDISRLQLRDLGSDHKIIEVVVEGGPATPRKRRVEAVNWDSFRDLRDDPTPICDIAEWCDGVLRTVKAATEVWKPKGTTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCY2</accession>
    <name>A0A9D4TCY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000824">
        <property type="protein sequence ID" value="KAH7985594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCY2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="13599" checksum="DE25A37FCF518BA0" modified="2023-05-03" version="1">MASSTVPLSRRAVRAMVQQANHSQLPTPPASAAARTYAQAVSGTPPPAPTPVPQPVDACLVLPSPASKASPVSPAMKQSASPTAQLRDDPRDAIIASLQLTMRAVGELLPSGSPLKAICLQAGDLQNTPSHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TD83</accession>
    <name>A0A9D4TD83_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Afadin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_025310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000654">
        <property type="protein sequence ID" value="KAH7985911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054708"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22711">
        <property type="entry name" value="FHA_AFDN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15471">
        <property type="entry name" value="Myo5p-like_CBD_afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06789">
        <property type="entry name" value="PDZ_AFDN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01781">
        <property type="entry name" value="RA2_Afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000032">
        <property type="entry name" value="Afadin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037977">
        <property type="entry name" value="CBD_Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="239"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="5">
        <location>
            <begin position="603"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="925"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7985911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1398" mass="156187" checksum="5552EF592A1B5AEB" modified="2023-05-03" version="1">MASERELKAVERINLRNTINQWNANRLDLFELSEPNEDLEFHGVMRFYFQDADQKVVTKCIRVSSTATSVGMCVCSSHACPTLLSFPLHEAVLLNATGALKERKLGPDERPLLVQLNWHQDDREGRFLFRRMDHKSRLPTLKVESLRFGRKLSRREHKKKKNKEVAQTEEKDGIAEKLYTELPETSFTRSISNPEAVMRRRRQQKLERKLQQFRQEGSPEAGKLARYYTLEPVHLHLRAGGTLRIFGESLNRDVPYKTLLLSTTDTATHVVREILAKYGLEQEEPQHYCLVQVLVPPPPGGLPSPQDPPTGGLKEFILDDDDCPLSIERQHNRLKGTQSFHIRRRPADYQPRKRKKKAPSGGGTVPPEEGLPFLQEVPQGGGPPGPCHPIPLHMTEIGSAPSGSQGLQLQGPGILPRHCVIAHTEGVVTVTPSQPEAETYVDGARVFDTTLLQHGATVRFGRSHLFRFWQAPPSRAAAPPPASPATMGDNHRPPHEEDHRLRAPEPEPTSMVAMPDQMGPIGAADHRDQRRGDPILPAVLELWEEHESLFLDAVINQLDWLSVQFKLVPAYTLYMACRYRASTHFRPETSPTERAQRLTALATNIGARVREAVEQQQRDAGPLAFWLANASELLHFLRQDRHLSAYTLDAQDLLTEALQLAFRQLVSAQRRELAQALPRAFLSPDTATDAPIGKFPFAGENVVLLRRCRVNAALTIQLFSWLFHHVNAWLLNSLLLHGRPPLCRPTGALLKRRLAHLVAWAEQQGLELAADCHLARLIQAAHLLAAPKAHPQHDLPLLADACFKLNSIQVRHLLERFQPLGPGDQVGPGLIDALVHEARKGEDARLAEEGRPLQLAEEPQLALPFLLPEDGYSCETVRGVPPGLQEFLQPLCLAGLCRLTLQPTSLGHWTIYMCDQDVLGPRIVTLALKKSPSGMGLSIVAARGSNQDRLGIYVKSVVRGGAADLDGRLQAGDQLLRVDGHSLVGVSQEKAAELMTRTGPLVQLEVAKQGAIHHGLASLLCQPSPLLLQRGSGRLSERDIPGRLAHEEPPPRIQGSKSVPALNCTASHGSQPLPWSPPTSSSGGNAPPRPEMGTRPLSTLVSPREQEQYVSSLGSLAVGHHSGPHGGPPAEPPAHWSPHPPPPDLRAQRDLLRQEAKMEEMKEEVRRREERDLHQPLITKPPMKQHPQQGVRSPPPPETSNGHHPNNRQVSLGEWNQRRLQRLEEMRQMRDEELQELESLPNRTSRQEERLRTLRLEREFERRAQELAGDDDDEEQVLEPASSSRVCPQDDEEEDSGYTLQDIDAVLNAPPGGYLVASTPGVIGAQEVYRDPRQRIERQRALQQPSRPPGPEKLTFREKMRMFARETGEEHTPRDKMKISRAQREIETSLNGVPTPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDZ1</accession>
    <name>A0A9D4TDZ1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000285">
        <property type="protein sequence ID" value="KAH7986772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDZ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044844"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21191" checksum="6D179FF6E87BDEFE" modified="2023-05-03" version="1">MRQQLKGREAVAATLRDKRLGDKPQVEVWFLGKGDGEILATHGLKRRGVVPHRSALFYVKYGLRAREERSCTDGSKSWFPPAMKKLEVRPVAEMGLSSSAMKKWRIDTATSQLVHRSLHRDQFLGVLITAEYQPAVASTYVSSLNDAAPHSLQKSTRNTHLASSMFWALGIKKQPLDEQLHRALDAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDZ9</accession>
    <name>A0A9D4TDZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_024672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000236">
        <property type="protein sequence ID" value="KAH7986862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052373"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7986862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="443" mass="49450" checksum="0890A8FC832004B3" modified="2023-05-03" version="1">MPHPVRLRTLHRVCDTVSGVNWRPTRFADELSVTRYACHVCRVIPSTTVVLPCAHGLCEQCHAGSPVQDSRRTCPLDGKSFGEGEYQKCQLLVKEEDLEAYCWNEQHGCNFMGPLVKVLQHFEKECTFHAFPCERCGENVPHAKLSAHYVRGCKCTPDIIDEVGVTPPPAEAPPEEGYEVVPALSSKVKELAEEIKIAVDQLQEFNSGLMSSLETISKFLERIEDGRRVQERARTSSEGGNTSTVPGAEASAGELMWLYWQMRRMSSKLQSSASSTLHLVEGIGGVLTRDCRPTISLSRVPRASDEASRLDGTGVGCSSKGDEVFYHLCVTYIDYVNTSDLVSASCRLYERNDFFEVRVSVESALESSPSKLDVIFKWNYEHGIRKNFPEVARVAIVSSDGFVDLIRCGESGSMNPLMYHTPNWKENYNNEGHLAFMIIIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE46</accession>
    <name>A0A9D4TE46_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000216">
        <property type="protein sequence ID" value="KAH7986942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE46"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039775"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF5">
        <property type="entry name" value="FI18040P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="49" mass="5661" checksum="0BBA4A88A69FE32B" modified="2023-05-03" version="1">MYFSDKTETKLKVVPFQAIEEVYVDHLHSVKSPNPRVTFCVKTYKAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YNE5</accession>
    <name>A0A9D4YNE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YNE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050909"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="326" mass="37204" checksum="295069F967F20990" modified="2023-05-03" version="1">MGHGKRICSILKSEWSRQARLYRIHLEAQLHSSLGAERARRVLWHFRHLANRTTESLWQCTLSQLRAHHRPKVRTIQGNRIYTEGDVTLPEDVSKGLALGPKFAVQPRNTGPELLSLVHKVSGLAPASEMDRCGVTHQWATGYIAQVRRDPQFGEDPQKIHDRQGKSSFSLGMHVMDATEGIHSCKYIQADVKPSSLLLGFREDNENRMYLADYTWACRHARDSKHKEYKEDIETAHDSTIKFKTGASTLVHARKGVIWKSWCTFCSSAVCCRLLWEDSLRYPEFVSQQKTTQIENIPLLVSKCFPHGDIPCGITVFLQYVDPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQ64</accession>
    <name>A0A9D4YQ64_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQ64"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="116" mass="12632" checksum="05D5EC65023F500A" modified="2023-05-03" version="1">MNNHRRPPQARAVANKAKSMHPVQVTEQESGAGGLTGAAGTRATRPARRRHTRGPSPAAPKGNGYVSSLKNMMARLMFMNSTSITSCCLENQSCKSRGEQGKPTRWFWLDAPSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQK1</accession>
    <name>A0A9D4YQK1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQK1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9798" checksum="D03B606A7AB5944A" modified="2023-05-03" version="1">MRADEIAEAQRMAQLERLSGTRTGRRILDQLGIRYHEARGLKEALLPEVRDAILTENIPRNMHPVHDLQRRKRRAVAILKQHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR65</accession>
    <name>A0A9D4YR65_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048998"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="165" mass="17216" checksum="2CD87992CAD3B130" modified="2023-05-03" version="1">MMEVTAGSAKRPFEEAGDQTRKAAAANGDETPPKAVTTRRLRFLPKPPIPPDRKKEGGCALFIRNGIGIVEEQLTCQRTYASVTAPGSSEESADLLIDEADSEEAASPASAREGAPSTSSSPPPGQPEKHPLAASVREPEDAPARAAVAASARKATAQGHYARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR72</accession>
    <name>A0A9D4YR72_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_024004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR72"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7984780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12599" checksum="119264341997F21A" modified="2023-05-03" version="1">MCLRSRDVRLIEDRHVVGNAFIFLAAGFETTATSLGFLMYLLATHPDEQERLHEEIETAFGSDRELSYEGVQQLKRLDMVVHEALRIYPPVVLFISRRCDKDTTIMMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P9S9</accession>
    <name>A0A9D4P9S9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serum amyloid A protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002126">
        <property type="protein sequence ID" value="KAH7931647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P9S9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046075"/>
    <dbReference type="OMA" id="RSIYCEN"/>
    <dbReference type="OrthoDB" id="6112826at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.110">
        <property type="entry name" value="Serum amyloid A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038350386" description="Serum amyloid A protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18438" checksum="3481E082E3F71C3E" modified="2023-05-03" version="1">MHASLLVVAVFYAITVSHSTAHVQWGDFMQCLQRRFGRSFFQEQHADCAARKLFVNYRRSMYCHNCNAYFHCQGNYEAIYDCQRDGRAQEVAEAFSDCREHLEGSGSDNFVYNEIDLYGRQGGNCTQAYLVDSPRCHYNPATVVCNNTRIEPESFEEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAV1</accession>
    <name>A0A9D4PAV1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001935">
        <property type="protein sequence ID" value="KAH7931840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAV1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="284" mass="30479" checksum="DE3C717C91544428" modified="2023-05-03" version="1">MDTRSTRRAASRTDADGPGVGNEAGADGAAETGGQQPSPGGTASSSRDPPVPLLETARAWLQDFFAFVAPVRDALARTPPMAALPKLDVPTFTGHAAGASITDFLDDLSVYRSPAVRGPRYPPSRGRVRTVATWTVLDSTDRPVAWTSRLPWEIQPRPLLGDPPLDAPEPFRGLLLSDRHPIEPSQPYTAKETRILCRVSEISRRAHQDGSLHRSRLLAATIRDTILRPPQPPPAPTTVEAAVALLRSARPDLLAQGVLPAPTSVPPPTLPPQPPVDDLLDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB09</accession>
    <name>A0A9D4PB09_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_007446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB09"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055225"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="196"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="424" mass="45763" checksum="E9B08E66B4CE73C2" modified="2023-05-03" version="1">MAAGDVRGVLKRPVVARLPRSAVMLTSLAVGVTLHLLFLQVGSCGAQVGDVSSEEQVQVFFEPDVLSVHIGDRRLYVPLRRKRAALESFPGGAASVANCTYEGRVYEQGVSATGRAVVIGCPGDKRVHALVLTAKGEAISVAPVAERLGDAGVEIDDLAGHVVRRESPMSKFLTSWSKLSTRRRRAVKTKAAVSSRERAIELAVQLILEYRSLGRPLKLEIVNLELVDSKRGPSTGGGDIDAYLDNFCVWQCNRNQLAARQGLGRWDHALMLSGLDLVKGNNSRVLGLAWVNGMCRCRYSCTLSEARSLEAALVVAHELGHSLGMHHDGPPDNRCDPDRFIMSAKTGAGKTNWSSCSGQYLEDFLSSRTSSCLASRTSQPVAELDGEPLPGQLFPADAQCKLALGTDYSAYTSSRSPFNAKRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCU2</accession>
    <name>A0A9D4PCU2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCU2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040434"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="8">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="732" mass="84478" checksum="5BE5353B566338F1" modified="2023-05-03" version="1">MSSFVSNGDKSDATELDEDRKFRKLDLYRPKEAPKQKRAEIKYDVPQPRSERMPVDQDWTSVWPTAQSFRPSVVPLPLRQGYREKGAPPGKYANLELMKVPNFLHLTPAHLAKHVKVLRPFCTPWPAGLETDEKCEEHFPVEVIDSDYCHASPSIRDARSRIVTLRVKLSDLELDYHARDKLLRLVGDRYDAATDILTIVTDRCPLKKQNYDYAHYLLTAVYHESWKTEPWEADKAESDMECYLWEKSRSEANAVGFVKRMQQSLAGQEEITLPHVQHLPPDFSDDDVKGVAQVKDYAEAVCEIHNEGESLQSWDKYKRSVCSLLGLKHSELSPLAGEVHASCSWRRVVPTPRALTLFLVLVGFGLVLFIYLPRSFEERLVRSPRRRIPVLLAYEGEAEVHTFFCDTHTTQCPRIEFTPASGWQGGIPGVPDLHLLSAHYDTRVWVHGGKNRHYVRLLGVIKSEDADSLRFFCQMWYQELPHPIVVESDRTEIWLPAWDGRSPPGRYYRPFIFSCPVPFNVSSPLNSGPANVSLVAEPCACPPNSLALSKTPEKDPKRGIAVCVKGLDFPEDISARLVEWLELQFLLGADTVFFYIFQVHPKVDLILRYYRRFRRVQFERIQLPGLDEPHIPAKRRQYLTNNTWQKRRHELVPYNDCYYRHIPTHEFVLLVDIDEVILPRRHSTWQELLNDIVSTKPKMLATYASLAVPNVYFFDHFEQSGTADTMIQEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE52</accession>
    <name>A0A9D4PE52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polo kinase</fullName>
            <ecNumber evidence="2">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_018527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038027"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="16">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="16">
        <location>
            <begin position="440"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7936126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="535" mass="60242" checksum="EDEC252AA9A6443B" modified="2023-05-03" version="1">MSAVLEPPATTRLRAQHVVENECYIVDPETRVTYRKGKLLGKGGFARVHELVDVRTQQVYAGKIIPRCQVSRPGQKEKILREIDLHRPLVNKHVVRLHDFFGDTENIYIILEYCSRKSLVHLLKQRGGQLPETEVALLMRQLAEGVRYTHSQGVVHRDLKLADVWAMGCIMYALLVGRPPFETSTLTETYQRILRGAYTLPPGLSDVARSLLVSLLQPEPQERPSLNEVLEHPFLRPPREQSGQLLGMLSRLRIDQPAANASRSTTRTSGHSGVQGSARDSPVPLGDCGLLGTLGRVLCPDKRSSKLGTTQLLYRLLQACLDEMPVSNCGVPPPWAGSALLVTKWIDYSNKFGFGFQLSDRTVGVLFNDATHLSFSADRLRLEYRDSHGSMEAHAPSSLPSSLQEKYGLLKYFAHYMEENLTEGGDVPKGSGRKKKPLVYLQRWMRTDRAVVMQLSCSMLQVNFFGDHTKLVLSAERPERPLVLYVDERRRTVAYTLAAFARFGCDEALQERLRFALGALQEFAELEQRDPRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEW6</accession>
    <name>A0A9D4PEW6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030245"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052710"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054640"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1885" mass="212589" checksum="9F6D5786BCC30EDF" modified="2023-05-03" version="1">MFILLLTRSRVSRSTSEPCRSPSCRRFMDLLEASMDTTLDPCQDFYAYVCSRWKPEAGGRTLLEDAMLEFQNVVMNRAAAVKVPTRNQNRFQKAVMLYQSCLATGDSRTSSFRGFLDVVMGSPWPDVNTSVDPIGILLDLSFQWRCPVLFYAFYTRGASSVGKLVFLDSSAGLDFPALFAEYRSRQDHGRYICALQAELNKGSDEFPGDRDSANHTKWCTDLARFQREVLSELEPHSHESGGTAYASLNQFAAQATPAVSEERWMRVMAAHDRRGENVLSTTPVEVDKPAYLKALTNILEDKPRTEVLIFIGLTIVQVIGRFASADLASLIYNVASSAGRKHQRTFCFQIVDVALPAALGNAYLFEDERVSKVKEVADAVVASTKAKLEGATWLTAQSRDEFIERIGHAALVFEGILREANATSENFSVASTYFLENAKYLPNDVWVRFKQRYGDDVKETSGGWIEPPKLEASTNEKALRLVVPDVYMSKEVFPDAAYESVNYGTVGSLVARQVASALYLIGQTVGGGGQRRDRLTDGRSGQNGTLECLVEEFERRDNLTLREDDKSALYVTWTSLAPLFDAHQSSPGLNEYSAGYKQYSPVQLLFITLCFIGCAQRTDSDSSATGFSVFLHEECASVFPQPRSFEYLVLDVRRAIYEESAASLDSWCSHSEQVPCWLLTFQGTLTRFLLFYDIEIAEIHLGTYSLHHVDSDFPKRADAEAILDRAREMRTEPGQFLHERECLITWLMRVHRCLRRVRLDLTEVAESPGEFCRGYRLHEGYKVLELGVSGRTLLSGRHLFSFLGHVTQLTELSLFGLYLMHPDDNCRLAALVATNMFLRKLSLKRCQIADRNLDGLIEAAKGLPLLECFSISLLNPGLWIERSQQLSRLLAGTGCRRLRQVHFGVACDLEPMLERLGENKKVIEVQINHELTTSSELMKLCDLAELNTHLKRLSLPIDMESALPTRYYQFILRKFIANARMEVLNLENSFITTRGVKAIAEGLKKNGVKETPQLPSEVRATANQDGRQRYLKELHLRSDKLTCEHLDILVDALDANRTLEVLEVGRVLPTPLVSHADVTRKIIDHAFRQRQHTASSQKSNPAATVRVNKVYFAEEFQLLIFAVRNDVTFRKLNLSFCDSPTETLKSHSFDFSHLLALLPFFAVADTLESLEIDVSLPGIVDVAFMGLSLLAATSNNLTELSVTLADTCCEFASILLFQGLASSVSIRSLTMSGWALKHPVPIWFHRFCRMNESLRKLHVHITCLEADDNTTFYEELPDALTECRWLVDFRLTCGKLREPIFIPEVLSTIRRNQRVQPRAVKVVSTAECAPQRVVKIFDRKLTLDMGVKLRRSMDVPEFKQHILERCMCSTETIDRAIETTRRWPTGTIAAERRTEGGQAQDAVLPMRATAFCAVMFRSRTLSTSVTDGHLSEHQVLKTEFQTSTSRGGHEDEFVDATRVIATTTASSTSSIQPECVDNPCLPESLYFKAQPQGLFSWQVPPCSDFYSFVCTEDLLNRTHPQWLPYKHASVGYLYRSALRYVRENVKSIRTMDTALAEVTTFVHNCSTAQTSSRTRETFLFVLESIGLGGFPFVKKHGNRTWRLDEAIALSLRLLDVAPFFHVKLPDVHAEYQEVLVSAGAEVAAGHPVRTAVKDLLPIHHWQWEHFLNVALKGAHSFDQSSLVMVENMRYVRKIAVLMGQYEPRHVLNFMALCVADELSVFFPERHARSSTAVRLPYRDRSLPTRPQLCLRFAERTCPVGVEALLLQALAGTNVREDLVREINGLKVEIMFSDALLGIGVDLSQVECGYDRTLYKHHPMRQYSEAYKLRLDKYYLSGNSTPLFRKVNGALSQYAPFAISFFCPYGSAMAKEPCELYRRNTRAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFS3</accession>
    <name>A0A9D4PFS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_018185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042050"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19386" checksum="6BC43C2E2EE09C11" modified="2023-05-03" version="1">MLYRHNVTFDNVATDVEILDSSCCMVTGCLYDHITWADAFVLVYSICERSSFDHARALLETLVAVRGARSAPMILLGNKRDLEHCRQVGVDDGHEASLHFHCQFYEVSAAENYVGVSLAFQSLIRETRALQALRTLPIRRKAGAAMTVSKMIGIVFGKSHKSNRNGKKRPSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFS6</accession>
    <name>A0A9D4PFS6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_021171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFS6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025832"/>
    <dbReference type="OMA" id="CKRSWAL"/>
    <dbReference type="OrthoDB" id="6501498at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="285"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7940091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="638" mass="70155" checksum="0CB6CC3A27B27E03" modified="2023-05-03" version="1">MERRRRANEREQARALARECATKADKKNRRLANDMPREAPLSNSDTTSSVSPLGRRPEPAQTAPYVPAGARAPQFYRAAPRRYTGFAGLGAAEVAPDVILFTPRRTPPSAQYAAPVIRDTPSPVRRASMGFGETPEEERVCKRSWALCAAAMAPVLFSTWMLLLPFMFRSNVTIVQLPPLPPAGADSPRVPTAATAAPPPNPLPPLPKSTPTKGTTQSPKSTTPSKDSCIDPPVIADITGAFNSSVYKPSAFLNSTSPSELICLFNNTRLSDGTGATRHYSVQSLPYQICSKLVYWSVGIENGKIKSRTPVFDQLYGLQQLRRTTDHLGYTGIKILVTVGGYGSDTPHFTKAGSDPAMLGKLTNSVLEAVSAYRLDGLALHWVQPRPECQSGGDRVSFVRVVLGFHWAFARSTVQSEGIIAVITDNDRISADYSRKVANVVKYFFVFAYRIPPRLPDPYRLCELFTEQTNSTLREFTRNGTDPGIKASSLCIIESLAPITVAGVWDSTTGRVQMPEDGLLYGRTPFHAACNEQSFCKDNRSHSCILQRAGGDKNHVTFYAISSLAQYHDRFSLDALGVGTGDVCVLITDFDYDNYDGTCNVPFVRYVLVRNLYYGSRSRVQPSQYGLYRNPDCDLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGY4</accession>
    <name>A0A9D4PGY4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_022495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGY4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="555"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7940218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="741" mass="81163" checksum="1FC813B2BF068602" modified="2023-05-03" version="1">MYRDGKAGVNLNPCPNPTAPVKRDYAFRRCSMNPQDCARYGVHRPSFTQTGFNDTYLQLPKHKTAPGDVLKRIGKSQCNTRHLKHSALRLLPVFGWLRTYRVKDYLLADVVTGFTVAMFQVPQSLGYTLLASVPPVFALYNAMFPMMIYIILGTVRQASVGADAIMSMMTGGIVRELISGDTGGHHPMVGTHNGTHAGQYTVTQVTSALCFTIGIIQLAFGFLSLGTLNVFLSEQMVNGFATGVAVQVVISQLGSIFGNHVPHMSGMFTIYKTLYAFFEHIHEVAWQTTLVAFVAIVVIMVVKLFLDPPVIRRLGIPLPIELTVVVLFTVGSHFLNLRENYGVEVVGTIPEKLPEPTLPSFNTHLIASILPESFALAIVSFAITLSLGRIFGQKHGYAVDANQEFLALGASHVFSSFFSCFPIAASVPRSAVQEGAGGKTQIVSVVNIVIIVLMVLFLGHYLEELPICVLAAIIVTSLKKIVMQVQDFKRYWDISKIDGQVWMVSFGATVIFDVITGLAIGVGFSLLTLIYKIQRPKTFLLGSVADTEFFVPIKKYQMVDEIPKIKIFHFGGPVHFANTEYFKEQLNKKVGFTVRDVLKARKRAQKGSTCNIANLVKDSPMLGAESKNASLNCSVAADLCSLKSSNSCVAEMLALPSHIVLDFSRVSFMDGSSVALLKSLKRDYDSVDVKLFIAACSDSVFDFLRKADAVEFLGSDAFFPSVFDAVQAAQHPNKARSSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHD6</accession>
    <name>A0A9D4PHD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 593 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_022547</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026725"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7940227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="124" mass="14681" checksum="9AB61A547C537EFB" modified="2023-05-03" version="1">MTRYSRKKTHKGYTASHKRDKTKRRTKDLDQIHVDMQPEQAERLLNQEVDYDMPGEAQFYCLHCARYFMDKNSLNDHLKSKNHKRRLKALEEEPYSQTEAEAAAGMGNYVPPKRRKVESQPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHV0</accession>
    <name>A0A9D4PHV0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHV0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13446" checksum="BA28969D92ABB828" modified="2023-05-03" version="1">MEGAACKPTNTAELGNDCVSICSLEDPEYQKIVAEHKQLALENEILRRQIKEERRELQEIISSLETKLEARLNALEANNKPTHATSKALVAHSPERETATVDIPQTFSEETRVSRSQMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIC2</accession>
    <name>A0A9D4PIC2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIC2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043558"/>
    <dbReference type="OMA" id="AIIRDMA"/>
    <dbReference type="OrthoDB" id="6606882at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="231" mass="24753" checksum="319CFA8F98DEC545" modified="2023-05-03" version="1">MNEDDSTTAAAPASSAENSPARARRGGRTRGNRLARSLSSCNCASYCYFSLALVLFSLGTVLTILVLDDSEQMFPNLTHMWLIGPIFISSGLMFAVKTIMYLRRETMIAYLTRQHSLLRELHLVAVEPGLLRGLQQRAASLPPPYEAVATGCDSPMCRGSTTAAAFPLLMATTEEDPPSYEEALLLIRGGSGASPATTKTLPELSPPPPSTQSPAAAPVTVITVQEDLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIM8</accession>
    <name>A0A9D4PIM8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_006562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIM8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031710"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21387">
        <property type="entry name" value="GAT_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024641">
        <property type="entry name" value="HRS_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12210">
        <property type="entry name" value="Hrs_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="385"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7943243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="748" mass="82254" checksum="B1393133852400FA" modified="2023-05-03" version="1">MFSWSTAAFDKLLDKATSHLLLEPDWPSIIQICDCIRQGDVQQTPTEAVRDKVLELVQAWAHAFRNDPNYRAVQDTLNLMKMEGYKFPYLKESDAMFSGRPGTRVGGRRLLPSHHCRNCGQIFCQKCSSQNAPIPRFGIEKEVRVCEACFEKLSAASKALAAKAPQKGSGSEQSSPSQTSSAPAGGKSEQELQEEEELQLALALSKSEVETNQRSTRRSWQPPSTVSNTATTNASSPPVSATEAGDKGPDKTRRKDLADGDPELARYLNRAYWEQRQQQQQQQDTNSVDGLPSRQSPIPSAPTSAGSPFTVPPKNAEKVDILGGEADSQLEEFVAQLRSTLEVFVNRLQSNAARGRPVANDSYVQSLFMSVTNMHSQLLHHLQQQEDLREYYEGLQDKLAQIRDARAALDALREEHREQLRREADEAERQRQIQMAQKLHIMRQKKQEYLQYQHQLALQRMQEQERELQMRHELQKQYHQGGAGFPNQPPGLPPQGMPPQGMPHQQPGPPVNMGVPPGPLPHAPASATPRRAHASRGTGIRSDDATPQGQPMPQGMPPQGHPIPPQGQPHVMTTQGHTMPPPGQHSVPPQGQAMPPQGHLSMHPLPAHSAPMSMPPQIPPQQQQARPPMPMPAMPPPYRSPTHVVATTVPMQYMMGTAPHAAIMAQGQYGPVSMPAPMGLPMDFQAFSMQQAMSMGMPMMHGAMPHQENPAASPPPQHHRPPSSNESATGAPVGAPPAVQEAALISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJA7</accession>
    <name>A0A9D4PJA7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJA7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="22082" checksum="DC103C19CBD9C503" modified="2023-05-03" version="1">MCPLYTRQIFKQFLTNRVLKDPKQRRFFKTNDLYELFTLADDGKKKRTETSAIFAGTGSDIRLKEKKKKGGGDHSASQAGNESTGMADAGAAETPGNTKQGLLSEEKIRQMHELARRLSQRISEGAKKPEEKPHHKRHKSKKSVVEGESISGVVKQAVFKPEVGPEQSQKQDDYVLQKLFKKSGMCLYFLNAAYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK05</accession>
    <name>A0A9D4PK05_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK05"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031430"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054296"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="3">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7944622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="389" mass="42301" checksum="4D84B576AE2C6F72" modified="2023-05-03" version="1">MVAAAVVSEAKGGERGPAPKNVAEVRHRKVVMTSEQQAGEGAGAPPPVPSSSPDDVTASREVGTFFSVMESSFVQIKEPSESSIETAHFLACCRSVLPVFNVLGGRVFAPIKADIQGNIDKLNEKYNTDKDGFARLMAMLQKEVDEGRNATSGRALEALLWLKRALEFILNFLSEIHGGNENLADCATKAYNGTLKQYHNWLVQKVFALAVHAMPSLRTFKRELAPSPKDASHPYYAKQLHADCGDSVVAAAGDGNGMSCLAMLSLPSLARTQLKTRESVRYLRSVYRPHNVRRASTTVPKVAVEETKAGEELAPIACAEPPVLFVARAGRLMSVPDAAISYGTDIVISPEPIRQASVEPSEEWHRRHLDPARLPHYYMALSKIRLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL72</accession>
    <name>A0A9D4PL72_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL72"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7946629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="23729" checksum="F5B90E9ADEBBE941" modified="2023-05-03" version="1">MLPRLCPPVKPFLPAYPRVWFWQLDATLAVNGVTAQPLMHDILLDALPPELHHLSAASSSSPQPYEDLCAAVLARYGETYRPLPGTREFRVSPPATRAVPPGPQPSHERDLPSPATSLSTSRPASSAAVPAPDDRPDDVQVPTPEVPAPDDVPAAIDQSATRCVSSTPSADGPSGIPAIRPSSLSSPSHDTSLTSASTLATLPHDLEADTDNLSPAVRPSLAEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLL2</accession>
    <name>A0A9D4PLL2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLL2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028860"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="561" mass="60256" checksum="BC535D463F7D966F" modified="2023-05-03" version="1">MASLKAKTEMVREIEDGVVSVAFRFAFFFIRLWAEVFHVSGQGGAVKWQQVSEDLVPVNITCVQDSPDCVFHITAYNSQVDKILDVRLVQPGTRLGQASECFVYWKDSHTGDTWGLNFTSPLDAKQFRECCSPAFKFSRKASSSYSLKLEPPKQKSKNSKRKPQSTPSSPSRGRAELQCTCMTAENLHRARNGRVRYTGGAATLPRAQQLSTRQGLEHTRSGTTSSQASARATARAQAVAAALTASSKQQQQQQQQDGASSSTTAASVHGAATTSRATTSGSSVSSHRRRAAAAAACEYSLRNESGSRSGGGGESNRLRDQYASRKEQAKSVDYSPSSPQLQASSRSKSSDNVFEEASGGGGARGDLAALSLDSNTLKRMLDPLPPSSSSSPDQQQPPPAQQQHLHQQQQHRRSVPSVTHGSTTPRLRDREHRSESGRRRSLERSVGLDLADGSPPSDHFLYDNLCYATTPPSSSNDSSSEEGDAAAGVSGGGGGAVASGLATPRRQASHEESPTSKLLMEYETHLRNALARGMDAESYSLHTFEALLTQSMENVAHCGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM23</accession>
    <name>A0A9D4PM23_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM23"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051451"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF11">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="384" mass="43257" checksum="8984AFE899B00B1C" modified="2023-05-03" version="1">MEDLLQPFKVGEDIALFLVNFERTCEKAGFPLESWPQELLTLLPCEAADVIARLSRKDAVSYDKIKEALLRKCRLSAEAFRQRLSHTRKARTSDEGSHGGRGKMANRHAECLGRGKGSVLALVSDGLQEVTEVRDTLFSQCGNVGSAECKGQREGSLKGSDKARVREETLQSQLTSLESVAAVVQSQVIIDDAREDAQLKGKPEIPKRRARKSPKLRVPWGSILGAKRIARKRMSMRFRRRGFRLFSSFSLPSRGRSATRCRAHRYRDKGSKVCTKRRAKRRKRPQDRNAAKVATRLRKKSARNCDRGAIAIIDRFLQHAFEPPRKKEESSAWFAERVRGQRNSPLFFSRNVRAGQQHVPSSNHDAGTTSASFEPKKSTMANDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMP4</accession>
    <name>A0A9D4PMP4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMP4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="113" mass="12901" checksum="6F01448A60DE09AE" modified="2023-05-03" version="1">MEMASQVTEFLWKRTRVSCQVRENHNKTLHNVTVLGNLTLPAKVEQVVNKGPKYSYEPRKQRHQLLAMVRTVADRAPEDDKGRLVGDGVASLKRTVSHKLPKKPPFRDVVKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNL1</accession>
    <name>A0A9D4PNL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNL1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7948216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="17325" checksum="A8EA2C146595641F" modified="2023-05-03" version="1">MPNVSFESKFKGVTRGVLRCETSRDERRHWDAEDVSSSSSSQELELRIETQKQTLASRDESIKKLMEMLQSKGVGAFDSVLGYDKLVTGIVEPPFGAIASSVLNAGAGAASCRSIDRLLATLPHQTALTSALGRQQSGCPVQNANHGIFSTSALNDLSALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNS2</accession>
    <name>A0A9D4PNS2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_015416</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032699"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="17">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="183"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7947735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="421" mass="47556" checksum="0EB85A9173BDAB6B" modified="2023-05-03" version="1">MSWFRLKKKDNKRSVDSGVIEEIGQPFQVSHVVHVGYNPATGDVEGLPEPWLKLLQHSNISAKEQSKHPTAVLQALKYYQHSIKNKNGVAKFLGTKETVEQESKEIADTVPEMSDDEGLDEPPEEEPVPSKALPRDEDHKPPVAPLASPVMRSKREEAPRVSEEEVMLQLQSIVNPENPRERYSLMNKVGSGASGTVYTATDRRTQRKVAVKTMELAQQPKKELILTEIEVMRQNKHPNLVNFLDAYLVDGDLWVIMEYLEGGALTDVVSETVMREEQMAAVCLEATRAIAFLHSQGIIHRDIKSDNVLLGMDGAVKVTDFGFCAQIRPDEKRHTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMLIEMMDGEPPYLNETPLRALYLIATHGKPHIKDRERRSPQLLDFLDRCLESLGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPZ8</accession>
    <name>A0A9D4PPZ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPZ8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7950862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16796" checksum="368DD4C0A935286A" modified="2023-05-03" version="1">MQIQTRSWKELTIYHKLTRDQREQVADLLSPYHDIFSDLPRKTEVLEIGKGACRDTSPDLSIWSDAGAIAWSNSFEDLGSDHRVLCVTVGEDESEVDICRKTRVVDWDKFRETREREKQDGPIEDIGEWCRILLADVERATKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRI9</accession>
    <name>A0A9D4PRI9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRI9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="252" mass="27356" checksum="BCD53A0715A45AB6" modified="2023-05-03" version="1">MAAPNQVTGYDPESLRIVSMDTAQTEAPMPTEEEYLQDMLRVWRGKKNSAVASRDAGALAAGQHTASRSQHAQGKSAPSVASQRIKQLQWRPKNTPRIEKDDIIVVLKPRETLDIKATFGPGQAGAAVRSILGADASVGLAVWPIWDQNVLACTLKSVDAAEKLLRDITLPVGGRQLPFRGHPKLSGEFCRGVVHVSQDETSETVKSKLSAEPNVVTVRKLGDTTVAVITFAGTKVPRTVLYNCERLPVHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSC9</accession>
    <name>A0A9D4PSC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_020927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038901"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7952257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="641" mass="71777" checksum="9C80FF7D991A1CF0" modified="2023-05-03" version="1">MLFFGTRFRGIAHRSEHDNTAERLHRKPRDRVFSALITGWRLKAPHSPPLPTFCPRSGAKNFHLPQSAAEVVASCNDDDELCPAMFVESQLDTPDPEVIDRGKLLENLLTISNSGTPVIQERTEYPCPLCRGTFRALGDLVMHECPKEKPPRSLLTCCFCSFATEQTTIFRAHLDLHIKPSLRCGHCNHTFPNENVLLQHLQLHGSSLPLEPLAAINSTSPYTAYLAPQTTPILANNNGTLCVINTPTYVVPVLEDYHSRYTCTLCNAMFHRLSLLAAHGLKHSEFPDIHIQENLLLPGRGSQEPFGALMCSQCCVVFTHPVALAAHSCNCKGEESSGTNASLLAGQQNTSPLQLIEQQPNQQLPQQLSPGVASSPVRLYCCPYCPYTSYLLASLIRHKEVHFSHRCSECSVRLPTMLALIQHKQKMHSGASASATPVTPAPPTTPVNSNGPHKRGRPRKTQEEIEIDKMGRIWHCKTCGVSLRKGAEDVATHKCTMFRCPHCTFETHKPNGLNIHINFAHTFRCQRCWKTFVTKQERTLHCTYSCPERPFKNVTEDDIPLAVLMQLSERKSYEQQDPVHPSKKPSEHSSGHQSGNTSQDRNEHQPEKDPGVVEAYTRKRGRPPKNRPQDNTEIKSVLWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUP2</accession>
    <name>A0A9D4PUP2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUP2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12004" checksum="2DDBE5A0B881892B" modified="2023-05-03" version="1">MDCVFGDCQAHGPVADPHGTGCEGLSGGAARTPTEWPPKGADPNVFENVWGHLKAAPAWKSLYSATSVQLWTQVNNAQESLKADREYVRPLYDSLPSRTAAVVAVGGDMTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWP7</accession>
    <name>A0A9D4PWP7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038932439" description="Peptidase M13 N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="645" mass="71407" checksum="B3464043EFBC6466" modified="2023-05-03" version="1">MIHATKLPLAAAFLLAGLVTAALFDGSHSRRTWTAAPSSVCNSAACSRLAALISEAANTSAQPCVDFHEYVCGGWSHVARSLTMADYAREAFIANVTQRARSFPIPEVQQTSEEKAARYFSACDDIVSGPEDHLDDVKRLLLNGGIAWPDIGTNPDVLDAMFYMSLIARVPILLRLSLRGNGESKAISISRAMPTFLAARRLERETRKATARKFFRTLYAAFSTNGGAGADRRFAVLADQEDRLATSLNAALGDAKSSSATTSDIHHWAKMRSKQRWRAAFHKYWKIADNESVPVTIESRNYFWAVFAHYRRFGDAQTMDLFGWLCVRALFPFTNQNIVSSYYASPAVQSKHRTHCFHQTDKIMHYAFQSAIALDMTSGLLVDDVTLLVTRILSSTDDTLTAGWLFFGECLIYDNSKDKFLNTLAKYDTSYTTQAYASFPDMTSDPLVNWMEAANAAPSAFSHLLPAGELVLGQHVLVDEPPIKPVYLDIPWYALDATRAVKLAGLGSRVAAKVFRELLSSNEMCLDLKKSAEVLWKCVVAREQEDAELLDDARDDVLVSILSSGVLWPVLEDLTKDSSSATANIQSLSEIQLFFVLGCLLLCGEEHSQAKCNLPLKDNVRFARAFSCRRGSPMYPKWTCSHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXU3</accession>
    <name>A0A9D4PXU3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXU3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038732"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="334" mass="37776" checksum="A02913087093181B" modified="2023-05-03" version="1">MSGTEGPLAVGMPLFKKSKESDDYRTKLQRKLYIAQESPDNTFDLSECALGDVPSGVFSKCRVFRKTTLILRNNRLTSISGGGLLKDLCDITVLDLESNLLAKLPDEFGFLRSLVVLNLKGNALKKLPGSFANLTSLQSLNLSDNKFKDFPPPILRLRKLRHLDITQNAITKLPNNFFELRSLRSFVLDSYNFSFPDAEVCAQPLESLMLHLCNLAGVEYVPPVDEPDTNDCKDETAATAALIGVDLDDQYKQFEERRERRRQELLQMEEELRESAVNRAAVSELTNKHRQELLLEIAREQDTLEDAILEVQSKKDIEKQKLVSLLLHLENHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY11</accession>
    <name>A0A9D4PY11_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_023158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY11"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30821" checksum="E705F11BAAD85F31" modified="2023-05-03" version="1">MSRSSHASCFVDWCANRSRSSSGVRYYRVPKDNRMEAFLRFARRPELMILPREKIHNYRICSAHFKDGDFMDLARTRLTWSAVPSMEAPAEEAEFPLGKSIPSQNYVNIIEAALAVPAPYRSPTLRKALQGYAEFTQQVFPRNGGLIGDLYNTFQATLAVPAPCRSPTLNQGRRGYAEVLRVTVLPRDVALASNIIWQGAISKERHLPRLVRLVLSGCTFPGPGKQRRQSSGPQEISHVGGLTCEPTEHTFTLLVVADKCSREDPQTHLVVTILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYE7</accession>
    <name>A0A9D4PYE7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041181"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058015"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039501124" description="Monocarboxylate transporter" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116047" checksum="37C2BE744603B7A5" modified="2023-05-03" version="1">MRAPLLTCAAIIACCCWPAGAQDDTTDAPEVATDQPPPVTTPPPPPPPPGINPNHSYYPPSYKPHFGGYNPNGYWNSYPSQGYYPHSWSYRPPAYHPPPTTYEWWRQFNRRPSFEHGGLNGGGGGYGYWPSAGSGYMQPYYGSSWWQPYYVAVGYYRRSSSPPQTGTSYPSYGGHYGGYGYGAGYPYVSGYDKFGYPYYRSGYYGGGLYGGHNGYGGGNTRSYGCYTSGCGSYAPSYPYQGGYPYNGGYPYTGGSYGSYPYKGGSYGSYPYYNSYATYPYHSSGYGGQPYYGGGHYNYGYGHGTYYPSGGGQTGYPSYPTGYYSPHSYGYGYGYGYPHYNQGSSYSNGYGGYSTGKYSGGGSYPYDYYGAYYNRYYPDYHRHYYYPGMTRGWYDCTYYPTAVNKGYAVSGSEGVKQKVDRTKQNTEKIKRTFTRRSIRELLKSAEYTGSETRRANDRGPMLDLSNDGLVGGIALLSQDAATKKDTTTSMFKATDNARSFAKAGEPNEGDQRITPEMVESFERRLTAMNRMFEELLTPKDMQDDGDYFMRRVRAYRRLLGQVQQRGMGIGTSPNDLDSQGMLRRLRMLENELDDRRRRALRTLYHALIDADLTVSDKLKVLATVYNFAKGDMSDESDEGAESMDRSVISSEAEAVKTPENGNSMTDADAKKFYDKLEKFLELTRTAEPSTSDEGGERKFETTSGASKSLSNSLESSSSESSSSESDSSGDRTKFEIKGSVSLALDVEGKTDFGTDTIAAGAAMHVPSSRREGTYASRGQGVYAAKPIGAMPALQLVDSYYAWFIAAMCFWIQVWAAIIFRSSGILLVGLVSNFRISREEAAWPFEICTTVNSAQGFLVGVLVRYWDTRTLNTGATFLAAISAIACFVWDTPTAYTAFIGLGFGAGSGLMVPTNVVVLHRYFDEYRTSASGVSFAGAALSSILLPPLIGRLLDKYGLQGTMLIVGALVLNAMAGSIAVRSTPSFPRPPHHPLISTTLTSARCSSCEDSENKNPVSDIFSTDLLLWESGIVVSALPPRSSEPQRRRRRGVRGHIWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYT0</accession>
    <name>A0A9D4PYT0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYT0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="591" mass="65686" checksum="A9449B88B7452E7E" modified="2023-05-03" version="1">MAAVFSTYARRHSHHAITEMDSDTEGSGQQPWMFGPLVNGDPVKRLSCFDPSCISQFIQLSRSLDSTVNPCQNFYGHVCSARQANGTVDEQMTKQTESRVVGFFKGIGSPDRDLPVASASRRLWKDCVDLTTLNKLGRAPLQALLNLTGLSSWPYAYATQSGQVWRSAGRLQRLMGLAPLVGLVALPDGAIQLIPGDQGSLEADDVLDSMLAMRRNNSRLRDLAADVADLGRRLSGLRERNAPPDSVDVQPPQLFLDAALEGLQRPGAVHVAEAGLLRQYVLLVNKSSSRSGSPRARASVLEHALTADAAEYVRYASLRSHLDFDFVRSTAAQLKRVVVAKLSELRWMDGGTRKSAQTRLRELKVRFFFDRYEGSNESAQARWPTALPSQALATFQRFREARFRSRLSQGDDTLGVQQECAYDAGYKMRDVQVLFVGLSVVDVREPESLTWPAFQAARLGPRLARCLLHVLLQRVHWSAASRARLDALRSHGCGNTVADSGALAPAKDVFDTQVRRLGKGVSTTPSWDKMFYLVYANSMCEDPDHQRRSLQHDAPHWERVNRPLSTDPTFQKAFKCQPQDNKRACSFWGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZJ5</accession>
    <name>A0A9D4PZJ5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_005481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZJ5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="10142" checksum="BD498DC76A4B1A93" modified="2023-05-03" version="1">MAASRMDVARRLSAFEFACHAMDVAFSEVHCLPRIPRPALRDRGNPMELYDEEQFHARYRFTKNAVRQLRSKKAGTTEDSLCLPCCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZM1</accession>
    <name>A0A9D4PZM1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZM1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12068" checksum="581F61892D1CB363" modified="2023-05-03" version="1">MAWYRSFVAGSTTPDGKRRSSGCAWLLGLPRLRSGPLQLLRRLALLLERPWCPLQMFRIGALEPPIRLLWSGLPFSRRNQSCLHYVCGPAFSSELRNPAGGAGCLLCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q084</accession>
    <name>A0A9D4Q084_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-alkyladenine DNA glycosylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-methyladenine DNA glycosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ADPG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">N-methylpurine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_013943</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.</text>
            <dbReference type="EC" id="3.2.2.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds MBD1. Binds SSBP1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q084"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053170"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.300.10:FF:000001">
        <property type="entry name" value="Putative 3-methyladenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="entry name" value="Methylpurine-DNA glycosylase (MPG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429:SF0">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7962001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="239" mass="26336" checksum="124DAD3066B4E426" modified="2023-05-03" version="1">MAAASRTELGAGAYASISDEWCSPSDSWARSSYADWADGTVLKCRVVETECYLGCDDQASHSYNGRRTERNEPMFMDPGTAYVYVAYGMYHCFNISSEGDGAAVLLRSAVPLQGVELMRRLRGARRKDAGRKLKLFELCNGPSKLCLAMNITKETLNKEFLPDSQALWLERDGDGDVPPEQIVVSRRVGIEGAGRESAAKPLRFYLRDCDCVSVRDRVAETRAAAQQQQVVAALQPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0H3</accession>
    <name>A0A9D4Q0H3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0H3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9909" checksum="C5D20EA9AD0E117B" modified="2023-05-03" version="1">MKTLISMDALVFIGKPSALFDETNPDWAPPSLRLGYSCKHAGAARHECTKKRRHEKWEAEAERRQHRLMRVDEAECGSLPMTVRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0K4</accession>
    <name>A0A9D4Q0K4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0K4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="72" mass="8166" checksum="D295E82DE8CEF7CD" modified="2023-05-03" version="1">MFHGRQNKRKVGNELRLPSWSLRVGDWDAPTQDWAIFNVTVASSERKASMAIHTVGRLWPTMLPSLLFQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0N1</accession>
    <name>A0A9D4Q0N1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 149</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0N1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027539"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46174" checksum="567134032C25382F" modified="2023-05-03" version="1">MSSSKYAKLEQDYQKLVSEMGVLRCRLESKSEALLILTRDLEQCQSERDQFKLMADQLRERHGELRRRLQAWSLAQLLCDLKEQNRRLQSENESLSQKLREALEDGKLLREQVQEQGRSRRLSDPCAQCSAKQDRQELVRQLEVLQSREELVRTGDAYRQKVDRLNLQLNHALRGGADYVPLDVDALLMENRYMHERLQLAQEEKSLLTASLNKFKSLAEKNRGRASTAALAGISSKQMQQLLQDSSLDLSTAGADLRSLVALLLEAVNDRTLALNHQRKANKVLGKRVTELENRLKCDGTWRVNMPLSSTDPAKLGNRSRGSSFEDANSLSIGALELSISKPTPDKDVPRSVISRENSRDEEEECIAGEEDLPPELQRLLSAAMKELKSPQHRAPPPTLKEVADLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q102</accession>
    <name>A0A9D4Q102_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q102"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028620"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7962528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="555" mass="62184" checksum="608195649AF29862" modified="2023-05-03" version="1">MVANLATGGNSRERRSLEQGNSSVTAASIRLGLRQGWHAERKLYQQRAHKRTKGWSDVSFHGSSQIPTPNLDALAADGVVLNNYYVQPYCTPSRAALMTGLYPIRTGMQGTPIGAAQPWGLSENVQIMPQYLKELGYETHLIGKWHLGYYKERMTPSQRGFDSFYGFYNGEEDYYTHNLTFVRAHNGHDFWCNKEPLFTDIGTYSTTLFTRRAEYIINNNRRCQPLFLVMSYQATHSGILKAFQAPQENIAKFSYIGEENRTIFAGMVDALDQSVGQVVRALSDAGMLENSVIAFSSDNGGAPYGPHNSRGFNWPLRGAKGTVWEGGTRAAAFVWSPLLVRRRRVSSELMHITDWLPTFYSIAGGNAAKLQLDGYDMWRQLSFGARSPRVELLYNYDYTFSNATALRNSRYKLVLDATGYFNGRYAIAGGSNTCRDLDSLLDDSTVARELRVLYKKSRLPLSTNWRNKATLGCGRGRTNFSPDSGVYLFDIVNDPCELNNLASALPRVVASLKKRIDVYRAAAVPTRNNLTVDPDAFPENHNGVWAPWAKPLVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1L9</accession>
    <name>A0A9D4Q1L9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1L9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054227"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF9">
        <property type="entry name" value="DUAL-SPECIFICITY PHOSPHATASE 11 (RNA_RNP COMPLEX 1-INTERACTING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="461" mass="51109" checksum="BA00120EDE2C42AF" modified="2023-05-03" version="1">MGRSKTVPDRWLDYSDVGGVVPGTRFIAFKVPLRESICSRVPASKRFTPHELLQRIQDLGLVIDLTCTNRYYDPDSLVTRGILHAKIMCVGQQIPSDGVVSEFFRAVDAFLANPANDGKLIGVHCTHGVNRTGYLVCKYMIQKLSIAPATAIEQFQNARGHKFDRDEYVSDLQRVGGQVPTLDLRSDDMRSHARKPPQAAGTEEHAREPLRVRDMQDQYVRNLLSSDRRQYVGNIQCIRDAGTKPPEFAAPVPSDGDVYRDFNNRPASGTLPYGHSAWNTARSDDYARAHGHTSDMPRALPPQGNVPDMRSHTQSYQNGVPPRPSAFVPVRPQHSYSHPSALPPQANMYNVQSQGQSYGQPSSMAHSLHPQHSLYDAWPQEQSYSNLGGMAPQHGSFNAPPQGYGQASGMPLQQNVPHAPSLGPVRTPSVVKSSNVVNADMYRGHGAYEPYGDDDGEYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2L1</accession>
    <name>A0A9D4Q2L1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2L1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32911" checksum="43E0F7393181667F" modified="2023-05-03" version="1">MARKSEIPPRVPLDANQMLLEMCNQDEPLTFKQALGMRAFKECVKIGEGTYGEVFRIGHGSKSSAIKIVPIEGSFPMNGENQKTAAQILPEAIICQELSALSRTDQAASCPNFIEVKRLYYIQGRYPPALLKQWDVYDSERRSENDRPDCFKADQKYLMFQFSDGGTSLEDYEINSATEAKSIFLQVACALAVAETALKFEHRDLHWGNILVAPTQKRHIHCHLPQGHFTLKTNGVFASVIDYTLSRLCKGRAVVFTDVSEEDELFRGVGDYQFDIYRRMKEENKYQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q421</accession>
    <name>A0A9D4Q421_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q421"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035362"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036992"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="74528" checksum="8130E895FF3591ED" modified="2023-05-03" version="1">MAYQVEGEFITPAESDDDSRWIRAVKAHRAAAAHQPITSTPPSLTLSNTHALPPNTTPTTTTLRRHAPLPRLPAEDFKIVFRPGGGLDLRTTTNGALLQTLCTLATIDHATARAANRVRINPYNNSLTVSTPSESHARLYLRVSELRLGSISYPLRAYMAAPDNALRGIIYNAVDSQTQEEIIQDLQSMNVNTPYAIADARQMGRSKYILITFVGTTTLPSSIVFNCGVYRCHPFRPKSEACTNCWTPGHRADVCTKPKSALCCRCGQAHNTVEPPTCVPCCILCKEAHLTGSRPCKLRFHRTGPSPSTHSKPQPPPPPPPTGPILKSSRPSRPRRRSRAEESMNTALSAASSCASSPTRRPPHKRRSPSSDAIAPHERDVVRDTASFLEAFEQRFMARFARLQERVVAIDTRVAAIESHLSALDTGVAALEARQSATEATLAHLLLAALLTPAATPTPSGVPAIHLELSGVPRQAEHPAAPPPEYPPDTIPSILALQEPLAPVKLRDYTSFHPSSEAHPNVATFVHRNLTAVLHQLNVSDCAHLLLEILPRRRTEASLFVLNVYSTPKAASAPLLLRYDVAKGARVLRRCHQSLLAYLFGRSFSSLEELVGISGQMAETLSSEQHCVLQTLPPCQVVPGGTSTGLAPSYCLLPRTFFTDPIVLAALAEGCTVAAPPLILQVQTQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7C4</accession>
    <name>A0A9D4Q7C4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7C4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39248" checksum="8F4A75B313474C92" modified="2023-05-03" version="1">MEVDESEVGDTPSDSSGEDTSDPTRRAEDGDAEGWIEVTASLDEAIRHEAEVSSDEIVTICPNPVQNILVISTPDEKTATKIIKIKKLTIYEKYETNAYVSAPEEMAKRIIRNIPLKYTQDQLMHALVNARNPSLAYAKRLGSTTTVILLYEGNRVPMWAHFNSIMMRVSLYRTQIDFCKECGRLGHRPDVCPRPDDKLCPACGAKNPAEDHECTPKCKLCGEAHPTADRTCRAKFKTPYMVKQRRWTARRNEEELQRTQSSPPSNAVAAVSTPSTKTMEEEEVEMVEEVAQQPGAKRKIPVTKSKEQEGSEQEVKRPRPSTKKTDVLEDMINKLSDKMEKMFEMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8F1</accession>
    <name>A0A9D4Q8F1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8F1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042019"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039314320" evidence="2">
        <location>
            <begin position="28"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="758" mass="80743" checksum="9868DD4A1882BD13" modified="2023-05-03" version="1">MSRLPTVATAANALLFLLTAGLCEVDAAASTSGVTTPSTTPGSSPKPTTRSTEYKNMDSHTLERTLSELRYGVELLVSKVTLLEPRLSRMDTAIGRLERALLRESTASESNSGHQTRFPPRPIGYASGKGCGSSSSSLSSSGDKAATVELASIGDQLRDLRDEQRFFRHMLGDLRNYTTHSSDRIIVSPFHPAYPRAWFMQLDACLAVNGVTEQPLMHDILLDTIPAELRHLSAASSSRPQPYDDLCAAVLARYGETYRPLPGTREFRVSPTPTRAVPPGPQPSHDRDLPSPATSLSTSRPATSAVVPAPDDPPDDVQDPTPGVPAPDDVAAAIDQSATSRVSSTPSADGPSGMPAIRPSSLSSPAHDTFLISASTLATLPHDLQADTDNLSPAVRPSLAEVSPSTVPERDLPSTSELCVSCQQRSASPSTSPAAAVRAPHQLRPYMRDAATMTVSPEDDMPVSSKAAPHTNVTPATTADVQYSDLRMGPHVPSTCASGISVKALCAAKLEQRGFLLARPAVNIQTSRPVIVGGKTSANGAAHLLRPQLLPWEAQPSMSSGSMSSSGTGSARPLHMVELKNNHRSPSGATPPFRSQGTATAHRRQDKVRGIFTDLFGSTRTNIAKHLRQATENVRRDTEIPLSRVADLADSLDAQTRKLPDLRAELAESAAAARVLELRVFTEDAYEPLRAAASLASRAAADLEKRMPPMLQKVAETATGLRAAIGDLRGALENATATVAPNDSYYVALSEEDDFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q927</accession>
    <name>A0A9D4Q927_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q927"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027844"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="14954" checksum="C404ECB0049AD571" modified="2023-05-03" version="1">MTDISTHHGAGHAASQGRSQQLLRQGKKIPKYSGQQLSALKASESDFMVGDLFDPKVNGHACPDDLIRAVQQEANNNNSSFSFDDDDLDLDDTKAALSAKPEALLEFVVVCPEPLDLLNDLRLPSRLGNLEAQLPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9B3</accession>
    <name>A0A9D4Q9B3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_009900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9B3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042450"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="227"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7972250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="705" mass="75893" checksum="79817613C75FD17D" modified="2023-05-03" version="1">MGMKKRPRSSSTAQGAPASARNGTAGTAGAISRGSRGSSLPCTPPDRPDSRPGGPAQPEAMGDLNADPREGSPLCSPRGRGKPKNESLKTTAPKTAGQAEADPTGTASAMEQAPLIPVLGTVRFPTSVGHVAGSSVTPLDHVLVFGHGKFQWVILLCTQLAVFCTVVHAVTLPSLARPVDHWCSPPPAYASLPPDLWKNTSIPVEKDGSYSRCFRYEPPFSAHDRDANLSLAVVPCDSGWDYAASLHSSIVAEWDLVCNRSWMMIAMTASYMGGTVVVMPFTGIAADRIGRAPVLVGALFVLVTAGTLLVFSTTLFMFTTLRVFIAASSGTLLVVSLVLLFEVTDSSRRVLYSSVAIAGGVSAANVYTELMYNLVDEWALVQIINMLPGVLLVGAVYFVQESPNWLLAVHLIGRLCKVVEAAARTNGADLERVAKRLEKLHEEDRRSRKDGCDTEGANRTSPLEVVTNPSLRSETLVGFGCWFLAMILFDYLRGSREDRPVYYTQIALECPTVTANVFLLQRKGRRITTAVSMIALGFLVAALGAFSLFFPDPSDADELARHLETAVRVVALLAVDTVTVSLSVITIEMYPTVLRGSGLSFAYVCGRLGAVTMTFASSSSRRGRAVELAVVSLLLVVFGALVLVAMPETTKIHATNMPRNVEWRNKEEDKWKLNEPLRVARDRRASSVANLRRKGSGAQLKSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAV6</accession>
    <name>A0A9D4QAV6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAV6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19310" checksum="E485B4C3FD443FC1" modified="2023-05-03" version="1">MVATARTLYSVQLVGLNPIQWESLDVVHRGAVRRIFALPRTSPVGPTLAETNQLPLSLRAKAGALRHVHRMHQTQQGQQLAIRLLSRPNSGMGRHALEYAALVPEMPHCGWLPIPPHRDRGLEISTTVPGVRSGRPSRDVDILLALADLLDCSSLRRPASRFLLPAARGITPVQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBZ9</accession>
    <name>A0A9D4QBZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_018639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBZ9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="352" mass="38818" checksum="C8A81211E190C2BB" modified="2023-05-03" version="1">MLRCTLYRKQIDVCHQCGRVGHRMDVCPNPQDRVCRGCGASNPDPNHECTPACRLCGGAHPTADKACKARFKTPYLVKKRRGDRRRAAAEAALELQQQNYDGEFAPASRSSSRSRSRARSAGSRPRQQSQSRSRSRSRTPGPRHGRSSSRRPKQAGHQDPDLPDKVSFADAVKGTPRREANGATASEPSNKRDPRAVALEAVQRENAHLRMVVQQLTQEIREIKLSMAQSSIPKPTSLQTPVANGNHGDAPPAKKPTVRDCRKEQVTVCEWRKEQEMRKLLADVKSAIRNIGVAVNNLTARTDRVESHVDRIETHIGLHPGTSMIPTAGPNVVHNSAISDSAHAQHYDGPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC27</accession>
    <name>A0A9D4QC27_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046553"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054359"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="651" mass="71629" checksum="D7B0DC86A42B7E8B" modified="2023-05-03" version="1">MRQAFPLTAPSGRVPGRPPLSPSLPDLWHFAAFGQRCHLDRSIWGNLLPFWELTLQNCHPKEPGTVYTDKERRLLCALRGVPEIHCSTHLTSDLHAEHAAAGWALRRLPTNIEEVLVLRTLRPDLLAHPQVARDDVILDMDAKTMCGGRLGATRKDNPRVRRADARGTTVRFKKHSPAGGMERPLASADGIKAAASLCGDKGEREDARLFLMYQEVHGEAATPSFRRRRTSDHRTVRLWLVGHLRSNRRQLPRRTPVDLPGLEPPFHRMGGRLEQRHEGLVTARMLAACFSRRDIQSDLQDSPPDWMETSSPVSLGLASRDRQGGKRRERMDEKTFRNELPVPSNSSPSQRRGLRPPAWTHGNQRNGSHPKLEEALNLWLSATVAKKIPVSGDLLKLKAETFALRMGITGWNGKSYVVDVLSAISILSDAWKAVTQETIRNCFRHAGFVNTEIGDEDSATDLDPLVESPPTAAADILDDLRASGVDVGAVDVPPSCGQTKEGRLKADKAKQLQEALDAEQQTVAKETRVYTRNADCGSHRNHGFEDMEASRRNMDRNIAERIQMPNRRPSTSGGAQRDAAGVAAEGCGPFYNMDATPTATPCVQPVNSFNDTPVTTDALDLDELPSAEDEGAVLETTSTASPGPASSTNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC55</accession>
    <name>A0A9D4QC55_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC55"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15689" checksum="265CD863DD2224E1" modified="2023-05-03" version="1">MNSLTPNRRAAYMEKPKKLTHVLQDCPRLHDKPRTSPSLPELLGLSGQTEENHFDRVNYTKDILLHWDRLNREVAITSARETPHTPSSAAPRTDTPPPCCNGSKQTDEKLAGPVRLQDPSLEQWLRQSTSITELPNTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCF6</accession>
    <name>A0A9D4QCF6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_005633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 8"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCF6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049370"/>
    <dbReference type="OMA" id="GWGTVYS"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.10:FF:000001">
        <property type="entry name" value="Blast:Protein N-terminal glutamine amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7975827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22842" checksum="F5A57A0F87A01C5F" modified="2023-05-03" version="1">MSDTSRDLAIPEANQCMYTACYCEENVWKLCELTRARQPELLPHCFVAFVSNRRQAVPIWCQKSSSRADGMSVWDYHVIFLYSPPPGRQGPSLVYDLDTTLNFPEEFDAYVREAFRPHAAINPEFVQMFRVVSAAEFLDKFASDRSRMRSADGSWLKPPPPYPCIQTNSCDNNIDDFISVDEAVGIGKVYTLAQFVQRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDF1</accession>
    <name>A0A9D4QDF1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDF1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026560"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7975780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="737" mass="84896" checksum="CED156BBDF9D50A7" modified="2023-05-03" version="1">MAQSKGTTGMLRRRSSVKLTPRPRPRAPPVQEPHTIRPCTPVLKDTSRASSCPRYSCFVLPAMLVTTATLLATPAMLLTRLDPWEQDKFTLDKDLKRSRNYSVHPCDDFYQHVCGHWDRDISRGYWSPVQKYEHFFHGQAIRRHLLRPIPKNPVKARDKASALLLKCLSRRGRESLWTLRNILKELGLSWPQKTPASRQELLGTLVKSSLHFGIHTFWAFFVGRHPSRPNENIIYTTLDERAIEWISTFERLIRFGKHRSYLRRCAEIVGGTGQSYSRMIHAVTAAHLLISQQVHLFWNPVGLPEYLDLRDPELRRALNGHLADDSQLWPENEIVSLQPGLFYELNATHFSRANLTENFKLFLGAYVVWLFSPYASSYLTTRMLEDAALESRAQRYQHQKCTQALEDILPLVMWESEHGDRNYKLYTWKMLHFTALSVDQLGEVYGDAFRVYFSNVVSRVGINAWNMTLKWEIIDSVYSYVPFDSTAGFLDMYIRISVRSIGILKKSLHRTSLIILYPPGSATFWLYRMLVAREVIVPNHLRRPPLFDVRHPLPVLVALVATVICRELVVLGRFILYYDENFTPVPTHPVYGQLVSLLRDLRSYASLLQSSGSVGHYTKRDSRKLIAASLAAHVANGITRLPEAQNFFRMAAEATNGNGRQPTFQDFREEQLYFLVTCFMECGSADHDASLQRAICNVALPAVVEFRRAFKCEPYHRLVTNFTWPEPPSWTTRYTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEC6</accession>
    <name>A0A9D4QEC6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036070"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7976386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="387" mass="43091" checksum="32344F8DD4015E4A" modified="2023-05-03" version="1">MTDLQRATVSGWTYTLTGFGEFLEMRRVAFAEPMPATCLCGVCGVLTRRTALLPCGHVFCESCKSQLPRGNDRCCPFDGKKFADSDIQRIELCELEQRRVVCSASRVCGFSGKLSELADHLTQCGGGKVKCRKCQRSVFRGHAVNHYRSCTGPLHAANAEAAAKADEMADVEKSARELMFIKGVDLEAVFSRFTNTLADKIASLERQLVEAQKRSNSNRQPAVPTEKEAAVIQGPYRAASRAGVLITTCKFANVCAALDSLNENKTQIVKPTATYSLGGYTFCLACKFSKNGREINADFALFLRDGEWDSYVEWPFKKKVTLIMMHPKDAEKDVRLPVTMAEHDMVKKPYVGSWNTSCFADSYKNWKDIELHGYVDRGALYVNVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QES1</accession>
    <name>A0A9D4QES1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QES1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="16098" checksum="E8150FFB4A213F3B" modified="2023-05-03" version="1">MLCVSTKELRLFEVDKRDAATLGPLIAKNVLTGTTVFSDEWAAYRSIPGLVNANGTPLNLDWHTVNHSVNFIDPATGANTQRIESEWQKAKRRLVRNCNKTTPALMRSHLAWLWWKSVNARPNVKDKFLRLIEAIARRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFB7</accession>
    <name>A0A9D4QFB7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052890"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="401" mass="44659" checksum="8F15737C7578A524" modified="2023-05-03" version="1">MAGRPRSSVNSIVKVFSTEARLTNLPRGHRPKVATDSDDERIVEAARRNPKMTAKEIRNDLGLVASTQVVRERLHVGGLRSRVAAMKPFVSFDAPNLHRVASSGRCSVNVWGSISKDGLGPLHDRSPVHTAASVKRLLEERCVMVLDWPPQGADMNIIENACAEMKKALSRRPLQKCSSDILWAAVEEEWQKLAPCVPHRQSARTESVVCSRRDISGVHRRACSVGMRKRTGLAAPRWRVHVSYGTNFSTLVHLLDQRDGLRLHVPFDVCGHTSSTVVGAFCSADAARYPSTSHGLRTGTESAASTYPHSRRCGGFIYIEHTLVLGSWRTLTARLSRVTDVMQLLPNVAKASAYCTRRTDAANEARQVASWRCHEGIYGGHLWRRGVRWQFGEHKKNWRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGT1</accession>
    <name>A0A9D4QGT1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGT1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047691"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="721" mass="80204" checksum="01A88D6FFA6E72B8" modified="2023-05-03" version="1">MLVALAATAVRGQSDFTDQATKQFLGMLFAPFGSKPSATAAASAPLYEAASRPLRSSAHHDEPEYGKPTYSLTPPRSYRRPESPYRAPASSYPRSKSRSGPWISPPEEHWVPPPSHWEPQPWNPPKPKHGAVTIKIRPAAPEEDHHHHHHSWEDHSHDHSHDHGHGHGWHIKKKPHYKTVDAKIRIPPVKFRLHVSPKIRIVSGTKDPLERPPPPEPEEHFPWEKPSTGWEKPTWKPPSGWEKYASSGWDKPHSGGWDRPHSGGWDKHHSSGWDKHHSSGWEKHPSSGWEKHPSSSWDRYPSSGWEKPTRGWERPPSGGWERSSQSGGWEKPAASGWEHYSSSGSWQSPSGGWKPDTSAWDKFATGWDDSHHKHFKPHHRHYPPDYPRYDPKFRIKVHPHIVTDPPPSTTTTTTEAPTSSSLRNEPPKPEERADRVDTTTAITSTTESTTAATTESTTTEPTTTTTEPTTTTTEPTTTTTEPITTTTESTTTMTEPTTSTTTAEPTTYSEKTVPPTLPTTTFYTVDTSVDLTTPGGLEREAPTSGSPTEKTTLSPDETTMNPSTYRTDETTMAMTTAETTAMSTTYTEPYEERDGVTPEILPEKRSRDPSTTEASNEDYPENKNSQEKPSDPRFHTIDDERAYKRDHGKKAETTTAEENSSEVVSTTPTAAQTTPVESDEHNEVTIKKPESSAKPSKVDRDLPLIADPSSPEEVSATGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QI22</accession>
    <name>A0A9D4QI22_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QI22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032537"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035362"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044050"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67412" checksum="013068C82347A337" modified="2023-05-03" version="1">MDAQPADGCVGKRKRHNTHFKSLHLSEEIQAAIKTAQADFERRASEQSHPFTPALPTPPPLPDCRSRKPRRRLLLTLIIADRAVIFYYTSNNLTLRIHLTSSCSRKLTPLFPCRATWPTIKWLITPSRHGHPHPADAHGQPGRFTLPCGPPRFYRDSTSETGRSFSLYTKCLQTPRVTEDSSLLALLRAAAVRDCSLTPRNLLRVGNSVCRDTTPDLRYCPYVHDARWSSTHQSLGSDHYVLTMQVCTSPCKPRPHAIHRTDWDAFRARCQHSATPDIEDLSQWTDQLLADLDGVTASIPTMANRPAIYSRLAHLHAAHRSLTNRWNKQRHNRRLHCRIADLDREIKTHTTALARQQWEQLCSGLSSQLGCKQSWHLAPTPSSRPYVRERTIQAYPGDTSSMMADLAAKYFRLLPSDELDADITEAEAYAALHRLRTTSTPGPDRVPNKLLRSLDAPSHIEHTLQCATDVVMDHVHAAGLTCSAGKSALLLIRPPDRHRLKTLHPTIMFHANSTPVPVVSHLARVLGLILQSNRRNTHTIDQLSLSIQQTARMLARVRAQRQAVVCVDADRYTSPGDTFTVARVSSRPPRRWPRSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIZ9</accession>
    <name>A0A9D4QIZ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040327"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="460" mass="52296" checksum="C7F270F070C8E070" modified="2023-05-03" version="1">MGRTRGKRSPSAEASNKRDSWVACTSCDVWIDIEDTPFESVEEASATAHYDCKQCVRLNILREEFTQLLRRHKEECALQLENTETRLSDALSQLGRETRMREELQARVSQLQTQLNDLKSATEGSQTEKLEGSHHAATDSATSRLPQKEDKKRRARDKEPNQAAPGSCPGSLEPRGEECSQVDDECALEVQEWRPTLRNKKRNDLGKSSSEMRSSNKEELKQQERFREPLNKSRCAFIYGDRNAFRMRHTTLRTVKWNKLVQYRTWKDATLQKVMTEMDAAVDIWSAPEAVVVVHCGSSDIVDNDASPDIPIQELKSRMQTWQARANKHRFIVYGVPEPEHCNDIMQRKCKLWNEKLRKVCDELGQQVEFVSTTRAPTGGVHSLLYKASAAEELGTRLGHRLCVFLGLQPVGPTVRRKRTSGYSHPLAPLMTALGQAMLQIAGKQDQGKRRKPPRPSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN67</accession>
    <name>A0A9D4SN67_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048151"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056217"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="1595"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="2127" mass="236402" checksum="215E94E1E1282010" modified="2023-05-03" version="1">MPLVCRVRATTKRHTGRERSQPSRKEGQAKKTTSQRARDGGSSRGEDDKDWAGLRAIGVCYHRAWRGPQLFGDQWALPDCGIPRKNCALLERVMLGPKQDGAKKEYVAAVKSYEELVDGNLVRGKMYLESKPQYEAGPMGGVGFGGMGGGMGGGFGGQPMGGGYPQMMGGYDRPPMGGGGGYGGYDRPPMGGGYGGGYGGGYGGGYGGGYGGGYDRPPDMYGPPPRDRYFPDRGRYPSPDQDRYPMRERSRGRKDDDYYYDELPRGAPSETKLPVTKESESRAERIIQKIRQDIEAFDKDDGAPGDATNAPSSKPSGSMERRPRTAPMRAMIRATDDYEDDTDARRRDSDDYDRRDRRQRSKTRYDDGDDMPRRRRSRRDRSSSSSSSSSSSEDRRRKKRHDSSDHGRKRSGSRRRSRTRSKRRDDDEDRPRSRQMGQGWDDDMFQPRPTADRNFIEAGMLYRYENQPLMLVKGDVVNKEEVAPAQDGGAPKNPDDAAQPARFLSPDQYQDFLLDVRAGKKRQGYPARATPSNVAQELGRYQDFLCSVLPEGTSAGAMAAEVGKYHKFILGTNTPHPPPKDYEFLVAANKGIAKVVKPVASGSAEDRHPPAGYQSFTVQAKPQPQPVKSTEEYHGFTVQALANPPPKPPPKDEVFSMQAMPSRPKSSTSDEVFAMQTMPRRTPSRPKGERYEHVEDTPQLKTEWWSRAAAGYDGTLRPASRSRSVRGRRGLARSASPRISPNRRKAYDDENADTYQVTSLEMEGPNGQQYAQVRMSRRPGDPGRMYSMNRRLSPTAVGYRSPQRVASPEMLPMQMQGMQMGGMQGMQMQGVPMQPMQGMSMQGMPMQGMPMMGMPMQPMAMQPMAMQGMPVQYDPQSGRVPMRMDRRIHQILTQQKGGGKRRSATTVMPVQAQVEGAEGVVFKYQIQNESRQHQADDGDKKTKDEIIETSKEPSVERIVSSVEIQVEEKKLSKATNARVKTRASAAATHDAGSMKNAEAQAEIEEIPHVNFTRNPNYDAPPPGYPFPMGSMFQPPPPQLSEIISTTTVHTHQHHHHYHDGQKNFKIAYLLPKSGDVRRDRSVQAQDRYEDQEPLGAAVGVQCLSLYERFMNWIYPDTKQTEDVSLMTDAEELTEDRKRSSKKGKKGAKKDAGGKSEDAKKDAGGKSEDAKKDAGGKSEDAKKDERKGIGSESEAEAKGKSPEASEKGEKGEEKDKQEEKKKDPPGPPIPVNLPWQGHEYEYEEQIKPDGSRVGTYRYKGLGGAPKFPDDQGPVKGPLRFPDGQPSKEPVAFETTTTRMEVNGQEFWQREVRPIPNSARGAPMMPMRESRETFHRRDREQPSVRSVSTPQQRRVTTRSRARVAERGGNNDDFVPDVQIRLDFGDTSDNSSSLESKTKSSGASAVGTASWQPADMVVSYAHKNFDDKNLVDDDDDDDMLPSGQVYGGHGSTKKLIRRGRKVRGMPNKELMAYSMVVLAALVGLALLITMNGHRSQSRQPFGLDRHLVLNASKFKAVQAGPANAGFWNAAPPVCKDARCLTRGSAAVKHLSKDYLKSACSDFYQFVCAQQNVTDSPRVIAYRALEDGVLNVIKGIPEEHAISERGWDPLAELQESTELSGWPFTDPVQQPLIWRAAARLLRRFNLPALLSIGVEKHPHKQGASILSIGHPELLLPPRVGNRSVKWYYGAVMHALSPFRERLVIPVFAVEVSTFESRLANMLRAQPKMAVKKLDDHPELTEASFLNIALENITHVTKSTEFLVKDVDFVNDLLSAIKETAPHIVLNYLGFREVVVASPFLPSKLQALSALGRSPALRKEICLGVVAESLPVMSLYAGFNAFKQGLHDFKAANVTGATKDAVSSFVKKTSWMDDATKAKAAKMVLSSRIRTFHPAWISDKFKVFAQHENVPMVTENEGLRSYATIRKTLFENTLKTEAAHIDESSRVNILVPPFSADGICFFLCLFFCSADAPVSFWNVSHPSHDNFLMMHMPDTLPKISRCLVSQVLREGAGDLASPYSQPTWSDVTKKHFKNTRQCFAKQLSETASQNASKTEILSVVAESAAISPSFKIYKQFVSQKNIDGKSFVKVFNMNVDQFFFVSYASVSDVTAGQQRTRLCVIQLRTKAKGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN75</accession>
    <name>A0A9D4SN75_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044422"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039760580" description="Carboxypeptidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24914" checksum="5A6BE82C495776EC" modified="2023-05-03" version="1">MTARIVLVFSTLPLLSVAFDQSTVEVKNLPGLEARINFRHYSGFLSGAEGRMLHYWFVESQRSPSDDPVLLWMNGGPGCSSLIGLSMELGPFRIDPSGMKVTLNPFSWNKVANIIFLEAPAGTGYSYDPSGSNSTDDHSITEDNYRAVLEFFENFPQFKPNEFYVTGESYAGIFVPLLAQRLLEEPHGINLKGYTIGNGFLDFELYGKAIMFFGYYHGLFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPM4</accession>
    <name>A0A9D4SPM4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_000316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPM4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032813"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7938781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="811" mass="92113" checksum="A13FAACA38E5E4FB" modified="2023-05-03" version="1">MSDPGAGPSRLAEKRAAEDPPAAEKPAKKAPEGESDSFKEFVDRLAATAPTLFRTEDEVRAIFTAADREFVSEEASDRRMSPCCTHYEDCSNVYVCWAVWQQKGWTKLLGPRGIELVELDVGRLRFRTLNVNPEDLLAADDAKFLCLCLWLLQQHRCISSVYISVPTVAPRHGLLFLSLLKLTMYVTKLEITCDDSFREMSVGDLPNPSVRIPPILSPRSSVQILNPNPSVRMDRQPWMHVLDNLCNLRELRLSSMYIRETDASALMYFLKERSACIVALVLIDVEFSAATFYSLIEAVKNIENLKDLRIKTSAIRHGTFEKALSLHRENHSLQRLYVHADCSISSWTAPITLARSLSELTLEPTIRILEDLEFLCGLLHRGGNRLRLKICLDMSEMHFAERCRYALMWLVWGSCVETLILSGSTINLDQSCALAKALTLTPSESYLKELHLDECGIECEAVEHFAEAIAFRNHFCSTFKELNVGAIVGDPLTQRRMFRCIRDNGVRGKITLICTECLIEYPYDWNINWPNTPFTKVSLSISDGSNVERVLHKLMDAAGTLESLSIDSNGGLTKMGGQVLANLIGTCSWLRVLRLRCHLTSNAAVLTLAALEESLTVLLLTVEHWVIDRKVKEAFEKMLTANGSLFRLEFYWEDFATYQGFKPFLKRGLLNNSCVMGLKMYQGELRDEIIERDPEILLSLQRNEMALAWATKEILLYRREEEGTLLAAFLDVFDAPLDLYQRVADFSQRTADNRVRLARMNTRSAYYALRYAFPNPVRPTTMAEDQEHLRDTIRYARRVVVEKLQSTDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQB3</accession>
    <name>A0A9D4SQB3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQB3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15201" checksum="8B6FF0760DD3D2E9" modified="2023-05-03" version="1">MLDKVEALSLVRAAAKKATAPEADRVVLECIEALPSKLASSGRINLRGIVQEKNYKLLQSDKEGAFVVVHPDQYRLLSDKAFSENFKAAEEFLPSKAKKVAVEEEDNGRIEFLDVLVERTPTGLNTSVYMKPTHINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQC0</accession>
    <name>A0A9D4SQC0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQC0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="12303" checksum="E801B5E77F0FBA41" modified="2023-05-03" version="1">MRKLRSQHDESSLVPHPHFLGGAADFQDEDSPTMFGRRFTEVKATMWGSEPSSACHMATLSLCWVPKNCTKRRLRIAVQEGVLSSRSPNELQGLEEPVRRTFGNRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQF8</accession>
    <name>A0A9D4SQF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQF8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="62" mass="7054" checksum="4FB14274616448E8" modified="2023-05-03" version="1">MVGMQCGFDAEFFEALKAKLDSKTEFERHGMLLFDEILVRERKSVNSKTLTYTGLVDYGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR75</accession>
    <name>A0A9D4SR75_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033598"/>
    <dbReference type="OMA" id="RYPQHAP"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7940315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21578" checksum="A7570C03B0874E96" modified="2023-05-03" version="1">MAETIMFAQKVVEMPARTPNKPPVRRASIETIVENLEQAKICKQEGNALYNDGQIKPAIRKYHQGLLHLKACQARYDMPQLGPGGPGLDKETQDEVDKVQAECYNNLAACLLKQPKCDYDRVVQYCNSALRLQPNNVKAVFRKAVAHYNMGNYRVARLYLNDAVRMRKGPDAMMKKYLRLCTEAESSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRK2</accession>
    <name>A0A9D4SRK2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRK2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049013"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF157">
        <property type="entry name" value="LRRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7944560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39314" checksum="ABC9849D1CF8667B" modified="2023-05-03" version="1">MSQIINKREYAAQRMNRSFGDRNRSRDTMYRGHAGARAALLLALSALAPSLCLADEAICKDTSGKYETSYTCEGFEDPGDFERRLDRSVVPRSSRGLSFILRDSRPRDFPVGWLEGINATLLEFQNVTLTSPESYDAVLSGLAGDAPPSSVERLVFSYDSTLPASWELLRKLPRLKTLGLVKMSGLRLGRDFGLLPRTVRGVSVLHSSIETVEDGWLAELPDLEYVVIRDSKLPHFSRSMLPIPALKLRSIDLDYNDLSAIPAGFGDGFPALAFLDLEGNKVTTIEERELAGVLNDTSTVVLLGNNWLHCDCKLAHLGRHSDRRLRARCHTPEKLRGRSVQSLTDVELNCPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRV5</accession>
    <name>A0A9D4SRV5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRV5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="473" mass="50519" checksum="BC371D657A91C33E" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFWQLDACLAVNDVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPPTRAVPPGPQPSHNHDLPSPATSLCTSRPATSALVPAPDDPPDDVQDPTPEVPAPDDVAAAIDQSATRCVSSTTSADGPSGMPAIRPSSLASPARDTSLTTASTLAALPHDLEADTDNLSLTVRPSLAEVSPSTVPEHDLSPTSKLCASCQQRPASPSTSTAAEVRAPYQLRPHLQDAATMTEAPEDDMPAGSPMAEQAKHVTPATSAGIQHPDQRTSPPVPPAEGASTRTGASSEPAATTPARCHRRFAPEPLTQDAAHLTCGHCPGALCRHPRQRCARTGKTHRSSYSPMVARRGFTAPFRIVSRTSPAPALVHPPSTPSSSRAHLRQPVRYRKTPSCRRGIRLGTTPAYFRLLPRPLRFSQSRPPETQGFPIVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS65</accession>
    <name>A0A9D4SS65_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_007562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044312"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF110">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7947116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="641" mass="70756" checksum="BBDFC29928218EF0" modified="2023-05-03" version="1">MAAPSSLLLAFKAKIEESVALVPDMGAEEKLKAVQFWNVVSERLQQIVNDSAADINALALNMHGEDINVASLHDEQESQAKMAQPYIEAHGYRSENLYTEAVEEFDVTAASEGHQQELLALSAELEQVGSSQPSTQGNFNGVPLEQGSLDVSERSLSKDSTVLLISTQAEDCPADATFDVAHQQSHDPGVLSQHEYGPNSSLVLQMPAKSVNLVQNKDNSEQWQSCSEYAAKPKVQRKRRPSTRKANAKSSAKRGTTPGGKKAMGVSAATDQRPSGTASDIQLESTQGVETTEVIVVQTRKKPKKSKEEKDRQCKVCLKELPNNSSLTTHMWTHERPFACAECNARFSTKNNLVVHQRTHSGEKPYACNECNASFSTRGNLKRHVKTHTGVKPWKCSHCEQCFTEKKTLVAHMRRHTGEKPYQCEVCQRRFAQSGVLRMHMAVHLGQKSHLCEHCGKAFRQRSQLHLHMQRHQGLRRYSCNICPSKFLTKADMLRHERTHTGERPYVCSLCGKKFTRQQSLNEHTNRHYGIKPFDKNPGYAIALKLFEVVVDNLRTETRIPPLPETALQIAGSMQSATSTAESGRIVPIVTSEAGNGHMALKGPETVVSHEAAMSGTTHATGVGRPAEFSAMDLLATASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST67</accession>
    <name>A0A9D4ST67_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST67"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042951"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="431" mass="48082" checksum="7BCED04BB2788DB5" modified="2023-05-03" version="1">MDTTGSAAAAAPARDGAAELGDLLVHLEGARGCFSGSLIDYRMPCTASEDTRCQIVASIPLWNEFLCWLKLELRELTGVGRQLGLVHRKNQGVPGNTYTDSWLGAMSKNDTLQHITLSVSIWTSECWEQFFRVLSRHRSLKMATIVAGEGELCRLSDIAKKLEKIGCEEKVSFVSSTSDDRFSLADCKNYSELRALDLQLSGIGFPTKSEDWWLPFSGSLLRNRSVTNLGLGVDVYPRNGFKYLGAAVARSKTIRELRSLTWSSSTRLSFLRGVRAGISENYALCSVALYPKSSYEDWEGDWSFVCDTARRNSGYVARTAQFLQQARCDTPCAAALDRVYRHPALVAELSKVLAISEADAVVAVRQHFRSIEGMHEFMRLAGVVKVHVTCLPRDDGRPQLNALDEYCWAHVRRYLQLDDVAWYCQSSTDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV32</accession>
    <name>A0A9D4SV32_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho termination factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV32"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8616" checksum="9BF7B7EFF52A95CD" modified="2023-05-03" version="1">MDIRKLTDELLLLAEELGVEVSQKMRKPEIRCAIQEVDFEEDEIAEAWEKICRIEKERAEAREGKNRGNKGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVS6</accession>
    <name>A0A9D4SVS6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVS6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="59" mass="6125" checksum="F2A44B948FB2D74B" modified="2023-05-03" version="1">MLPAIQASVLSASREGRTVTLRFEAQSPRSKYPGSGYASRCGRPAPVHCSADSADASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWT7</accession>
    <name>A0A9D4SWT7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWT7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055946"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26321" checksum="F98A2870FA8F0877" modified="2023-05-03" version="1">MNTVELYVDGKCFRCQLTNEQLENLQAGDTTAEAQSKDTTLWSEGETRKLLEKFTNCMPEVGPMKKFKDKKTMWTAIAAELRHETGIERTPLQCENRLKTVKKRYSNARKHNRQSGVSPVEVPYAEEMSKLAAVDYGVFPEVMRGVGRVERNPPHMSQVSASAGQANVQASGVDHGSGAAQETDVAASPSASKRPRTSQSLANVLWMIHKDREEARERRHQEKMALIGQLFSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXU8</accession>
    <name>A0A9D4SXU8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXU8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045891"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050781"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="410" mass="45303" checksum="DA9F5C520523CA23" modified="2023-05-03" version="1">MDSVSFDDYVSSDEAARTSAELTTEDILSTAQDHEGSDDGVDGVGNNETVRIDGDAVLKNAQHFGANVTQAKTATHVKLEEVLLMSFHEVTAAGINVDSKVLRDKTDNIALSLGIDDYQASCEWLHRFMERHGLVNRVVSCEAKKVDESQDAASKEENRKPDVNLQVEGWKNLGTEASAQDFVTADDNVATCGLRSIEDLVNEAKETKSDSDCEVKCLTSWRRRRKTATPLCPALHHKRRQQFSVRGREGPPDFSVSRQDPTVVGEGLEVLFSVFSAGLRDHGPRRPPLRYIMWGGCNSAVDSGNGQCQDATYPEEVRAWIRSEDLKTQRRAIQRLEEALAKQRRKGADDPSNERGGTRAAIGSSGVLTRLEKGESGVREPAPYHQQDLLPPRTRKKQAESALSPPRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY54</accession>
    <name>A0A9D4SY54_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_000739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY54"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030627"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="489" mass="52768" checksum="914511C0D4A5FC07" modified="2023-05-03" version="1">MKLEECRIATMEVRALSLRAKLRKFAKEHFFLLFTLGGVVAGVVLGLGLRQASPSESTIMLLGMPGEVFMRCLRMLVLPMMIASIITGSANLSGKAKGKMALLTFAIFIGTSFVSALIGLSFVTIIHPGSPELKSELDVEDEVKASAHLLDTFLDLVRNAFPENLVEACVEQGYTSYEKKNVSIRGEQAKEISKRNWSRRSGTNSLGLIVFCVVFGGALGTLGKPVEILKQFFAALDVVIMKLVFLVMWMTPVGVMSLLCARILSVGSIVALFHQMALLVATVLSGLAVELFVVECLLYFLVTRKNPFKFLGELAYVGLCAFVTAASAPVMPLTLKCLEENCGLDKRVTRFVVPVGVTVNMNGTALFITVCSIFIAQLNDIAISSGDYFAVLITATAVSVAATSVPSAALFLMVMTLSVIGAPVSDVSLLFTVEWLLDRARTTNNCLGDCFTSALVDHICFRKKPCELNEVVVVAADDGAAEKLRDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY77</accession>
    <name>A0A9D4SY77_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_010192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY77"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046295"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="356"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7956528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="803" mass="86519" checksum="B4B693A219558019" modified="2023-05-03" version="1">MNNPSSSSTQGTSASASATLLANAPAARLCHLVRWPEYDGYGFKLVAAQQGNLPRVTAVESGSPAEAAGLRANDTVVEVNGAILEGLGHQDVVQLVKSTPNEARLLVVDDETAAWYKRHGITLRGDLLSTIRVSSKASSRKFRKKDGTTSSRNQSSSSMTSSVNAVSVENRSYQEIMWRIGKEADQVDLLVIDRETDEAFASREQKPSGQADGVLRRWTPVRPPRSTFRKTKKQTPVVKAGSTGGLASPQAIGASLRPSMPSTANDASHGLAASSEHLVAAEDVTKSDCRPHLPTTQPVLLNCASPIATPRSGTYDSGHTSISVGSSESVSRAPSSQPMDNRCEARLCFTIFAIVYMALQEPSEGLRLCHLSKWPNFEGYGFAVNADRYRNGQFVAHVDVGGPAHLGGLRKRDRIVEVNGESVEGASYRDVVNRIKVNPDKVALLVIDRETDEAFARQGRTPNSQEDCVVECRTPPEQPQSYARASGFRSSVYETPRVPIKSDASTVVPGETLNDGSTAAGKSPGNQLTNSFWPVKPASESVPLLVARPMMLVCPESRQHEDEAASLRGQQAKHQPAKSEPRAVASKPFPSLYTIKESPSPPTEPYDNGSPPRSPTRSAADYFPAHDVCSAHTSTQFTPPESHIPTDYDSPHYSPPRPILPTAKRTFSAPSSAGYASSQPCGPYCPAQSWLSTSFQAPYVPLETDLQQERTTTYAPGYSEFLSMYSGYASSAPLKSATETTSAGQTPTERHCAEDVKATHCNVMDVQSGLASRVVSTETKHRARSPTNEPNDDKFGAKTSDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYG4</accession>
    <name>A0A9D4SYG4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYG4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051451"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF11">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="492" mass="56458" checksum="1CB08DCCB1C35D2A" modified="2023-05-03" version="1">MEDLLQPFEIGQDIALFLVNFERTCEKAGFPLESWPQELLTLLPCEAADVIARLNRKDAVSYDKVKEALLRKCRLSAKGFQQRLSHTRKARTSEEGTHGGRGKMANRHAECLRRGTGSVLALVSDGQQEVTEVRDTLFSQCGNVGSAECKGQREGSLKGSDKARVREETLQSKLTSLESVAAVVQSQDITDEDREGSSVQPFGALTPQSSSRAKRKRPQDRNAAKVATRLRKKFGRRREIARRVRLSLLTGFYSMRMNHQENRRRVAHGSRNRSEDELMRNHQDSKRETAEEHVDADEHRRRTECSKVCTKKRAKGRKRQKDRNATKVVTRLRKKFKSRREIARQVRLPSGTGFYRMRPYRRKKKKREAHDSRKESAGKGTSRCSFRRASDQVRDCRRPSSRKKKKREAHDSRKGSVGKRTPRCSFRGTLKQVRHREVGDLREVAGGDKEKSATGKVVRLDEGVINFHAYRTPRLTRKAFWARPPRVRLKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYH8</accession>
    <name>A0A9D4SYH8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYH8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="486" mass="53810" checksum="0B2E89F429A3CF72" modified="2023-05-03" version="1">MSRHCSIAGTCSLAPAGDRGRQDEVGPVEAGGRRRRGMRAAILLIVEFTAIAAVAAKAAIIMDGSVASAAFREERASTAKPQRWHDDDASATSRRRHYDSPVFDQIIVETVEQPARHRPSLAFILAVFVTGLFIGAIALLLCVLWLLKALSGRYWPVAQRDDTLCVIEDHGRPLADIKFKQQQANVPLETPIVSKECDVAQSARDGTSVRDVKYTTRNAQHSARQTPLQRARDGPAYKAPTGEYREPQYSRDRQQHARGSSNWSKTPLKSSTNVQPRQELYIDDESVDDRNSAKALSNLRLNLRINEESSRTNDSGGGGFRQHTPESYSSSSYSSGENTAISQASKSRSIRFCISPEKKGAKDFGNKTSLMDTRTHSLKESRALPIADYRASQVTKAHANFIGEENTTEVYQSTRNNEASRPRSKNSEYTPRPASTTPLFGRTTPQHDDGARQHVVNADQLKLDQVKVLVDEILNKKANRKVKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0X5</accession>
    <name>A0A9D4T0X5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0X5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045535"/>
    <dbReference type="OMA" id="WNPGIHD"/>
    <dbReference type="OrthoDB" id="5771378at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="328" mass="36399" checksum="5317315FB3EB1708" modified="2023-05-03" version="1">MADAAAAPTATAGTETRRHQATGDDDQQEEHLLIRHMRPDELKQAMDIWKEQGLEESENNVSTFYQVDPEGFFVTVDTRTGRVVATCACVRQHESLFFVGMYAVRKHLQGRGIGIRLWRTMARRLGDCNAGLNAVPKHLSTYRDHAGFGHLDTWNTLVYSGTAVSTDKLARPTEELRAVPVTANLLPQVIAYDALVHCYNREKAVTYTVYDTDGFARAVVRRRPDGSEVVCGFGKIGTNILGGAMMGPLYAEDRRAADVLLRALVDGNPLTRVSLTMMVVDCNPDGVGLAEDLGLESHMRVPRCYRKAIVPARFEQIFAQHDLNFSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T124</accession>
    <name>A0A9D4T124_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_017615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T124"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039404"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7962716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="403" mass="44411" checksum="399755AB6EED701B" modified="2023-05-03" version="1">MSSVLEELSVSDNETASETPVTAEDLFGPHYAKTLRIALISVMLVLSLLGNSIVCHRLLTSRRHRMFKAQMLFLNLALADLLVTLVTMSSQLVWEVVGRVWVAGDAACRLFKVLQTFALVSSTYMLVGIAVDRHYAICKPLAPAPKPRSLVAVCWLLSLVPSLPNAFMFRLVVIRDECYCASVFYIYQDSVVPRQAYMAFVFTLVFIFPLVALVTLYSCILYRMWKISSIASNRQRGDAAAASCGGCAEGSSTTLPKARLRTLKMAAIIFVAFLVTNLPYMVQEMLLAFAQNVSLGPHIVAVFGVISASNSAVNPYVFLAFNGGAAAFGCDAHVRVLWRRLACSSGSRRTTATFRTAWSTLQTRNRRRSPTVKMFPSPDNYQCGEAQQKGLEIDRMAPLGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1A0</accession>
    <name>A0A9D4T1A0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1A0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="131" mass="15302" checksum="6CE04A797BBABD00" modified="2023-05-03" version="1">MELMKALSTPKRPRVPVEDTATKKLCRLSDNSDLIIYGETAEACQRHHEWLMENASTAEDFELRPRLLATAKERHDRLQCMTLPQALLEYPFLAAEQSLLLEFDLLFKKKICDEISRGFQRMCDFILRHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1T4</accession>
    <name>A0A9D4T1T4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1T4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15456" checksum="A9E6B10F60D03A7B" modified="2023-05-03" version="1">MGSPPPAANESSCSENRLYTQSGLGPFVFGEKMLLSDYAKSLSDPERRRYHIKVAKCGSDDPLAFSDDQFTNDVGCYPSVDRADINDYLVHGTSFVTREQLKSYKSLEAHNYVTSGLVEPPRANDLIAVASVPCPSYSLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2E9</accession>
    <name>A0A9D4T2E9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2E9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="420" mass="47063" checksum="3BCF4A9F82897F0E" modified="2023-05-03" version="1">MPANDYKIVVRPRDGLNLSVCSEAEIADCIRKTLRFPDTTTITDVVQVNRAQNLVLISTPDEGRAKTYSSLSEILLHGKSYKVSPYVTAPDDSAKGILHGIPGYDTQADIMASLQNNTPRVLQARRLGTTNSVIIVFEGPMVPHYVKYRGTLMRCLLYKKKIEVCSICRAIGHRQDICPTPAVKRCQKCGQDNPLQEHECEPKCVVCGGPHMARSKDCRKRFATPPIIRRRRLEQRVSQSPQEPTPHRGGHPQRPSRSKERKRQEPGAARSRSRSLSFPPLPTKPRSQSRPRNNQVGWASGPPLQAAVDDKKLQALEAQIAQLSEIISRQEKEIAQLKQLQRSDQPTTQVLANPNEPSAAKEDNNLDDNSPPPKRKAPKVDRTTQFETRVTDLETKFDSFQTSLAQLVDTVDNQYDERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2P9</accession>
    <name>A0A9D4T2P9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_021588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2P9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034434"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000038">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="306"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7969706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="598" mass="66198" checksum="A0082332055F6994" modified="2023-05-03" version="1">MRYSHRIILLVVTATSFFFLRILYLRTGSRSARNWWAGDIVDFEGADNVTGFERPIVPNVVHFVRLGNASLSLVEAVCIRAAWIQQRPASLVVHCDRCDESTRSSPHWPLVSAIPGLRLATVKRPRYVFGKRLSSIYHASDVARLRILRKYGGIFLDGDSYLVRSLEPFRRFEMALGWYPKQALGTQVLVAHKNARFLELWYNSYRYYRPELWYWNAGRLPTEMILVPRPHLVHRVPYDFGVHNVAHLLYGVCKPDWRQFFAIHLLFRHRSYLVTTDTFGPLTISNVGRYNTTFGQMNIGSFPDYVKVVEVGARDGLQNEKEIVPTNTKIELINRLASSGLPVVEATSFVSPKWVPQMADHTEVLKGIEKHKGVSYPVLVPNMKGFKEALAAGAKEIAVFGAASETFTLKNINCSIEESIKKFYDVIEAAKANGIKVRGYVSCVVGCPYEGAVSPEVVAKVAGMLYRAGCYEISLGDTIGVGTPGTMRPMLQAVLKEVPATALAVHCHDTYGQALANILTALAMGVAVVDSSVAGLGGCPYARGATGNVATEDVLYMLHGMGIPTGVDLQKVIGVGDFICKALNRPNNSKVSRAISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T324</accession>
    <name>A0A9D4T324_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T324"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041451"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000052">
        <property type="entry name" value="cyclin-I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="182"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00073755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7968143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="458" mass="50711" checksum="72D69C48E2DE1F74" modified="2023-05-03" version="1">MGKDPRRPPVVAEASEIPGVCRRPESCLGKCRGQGRASQPPLTESASADAGGGAPGLAILESSRSKLAERESYLPGQETCNDQRLPHDAEMDTTATRLTSLSHEDGQRDTATAGETASMTRLKRVHFAASAAAMSIQAGLTADSAIALVQRYLRKERLHWRPSTYASQGEEITPVQRNHTVKWLTVLNRYLKFNPETLFLSVTLMDEFLLLVRAQPKYLKCIAISCFYLASKIIEEDEVVPHIKDLIKNCDCIFSVSEITRMEALILKKLRWDLCRATSLDFLHGFYALLVLNRGLLLPDQSEQQLAALGPLLETKLQICLDQASLVATRPSTLALALLSLELETWTPNWFVITIALQRLAQVENSDVIRCREELACIFARARTAVSRKHRHSDSQNAHKPSKRRMETTDIEDIYDSIKRLYGEETASTTSPPAASVSCGMHQGQGGISIPGFPVRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3Q7</accession>
    <name>A0A9D4T3Q7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_012125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3Q7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040189"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="193"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7972437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="784" mass="86674" checksum="2E2B9872590FA568" modified="2023-05-03" version="1">MDAATAVAGASTPHSSNSSSSSGSERNESRGSRLITGHARLPSREILELREFHEVHQAEVDTRPMANVAASGDGTNTALDSSGTSAFPLPQPTASAQERARLSVVVMQANWRMNPRHKTILDATAIISIVAFVLYLGATMWIRVIDRGVFHASSQRTTHTEHADLPLFSGCVEVACNKYMAAIERSINRSQNPCQNFYRFVCDGWKHQQDPLSAVDAAEAAMYRHALSAIEWSSEDTGGHLSTAPSALGVAKKVAGLAKSCKELSQSSLSDLKRFMAERHLPWPETSRWDLLEILLDLSGNWNVHLWFHVSFELAPFRGRAGEPILRIGHSAAFRTWIATMRTFAGQRAGTAASLRYRRYVGAMLDIFGVSEAVRDEVADKIEAVDRFTLEVLGPAMAETDSQVLRTSIRNLTATATPGIAAGRLLLLLNEYFIWARRFTAQDIVQVENVGLLRSVVYLLGLKSNVREGLTLSLGLRVAHELGWMASREIADLTLELASLPLSAHWHRCLMQVESAVGTEWLSLFPERRGVVDFTRDVQDILAGVLARHKNTLLHLQAPSAALPRTNDSFLATMLPEPTHGAPFFVDWLKLIKGRWRLLEQDMTNVLKPGSFFSHRWSFHGTLTVAEDYFVFPLFHTDFPTAVNYGGAGRLIADEVLRGLYYNHLYYVNPFGDHISRKDYVSQSNSRSSAAVDWSPYLVDSKALLASLAAYRLSAARNPSSAYSTESSLAQDRLFFVASCYALCSSGNYVDVLYGDASHRCNEPVKALPEFTAAFQCTNPHAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T410</accession>
    <name>A0A9D4T410_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T410"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058353"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27387" checksum="5B0EEDD0A18462FA" modified="2023-05-03" version="1">MLGFHPHLSTQDAPLQLHHDLLDPPIFSDTEVLLSLGLEKALDHVSHLAILAELDALNPGTCTYNYIGVFLTARTAEIIIGDLPSPTYKLGPRGTPQGAVFLSSARFLACWTSRRALTATSSRRCNARTDVVTSHAYAADLTCSAAKFAVLLKRPPSRRRYKSPQPTFTVHANSAPVPSFRTSHHGRHRSKTLSRRGGGGGHRFGCDLGGRSASYSMTPDKLSPISREVPSRLLSYDSSARYCCKTTSATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T432</accession>
    <name>A0A9D4T432_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T432"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029020"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12438" checksum="A8C81461D37F8F56" modified="2023-05-03" version="1">MSPMSITPLLLKLRCEWLLVWALRAVLLCGAGHFLWTSFFTSSSAGSRSYGEQWERPVPIGYRIRTSGCTIPRFDPFDPTVKPFIPRSFKRAQCPGKPNFLTLRCGTLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6L6</accession>
    <name>A0A9D4T6L6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6L6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7973304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14701" checksum="561C7DF34D34A46D" modified="2023-05-03" version="1">MTREVAGTSRCYFLQDVAIPALEDFENPSVNAAEVAESRPIHRSSTTYYQRSLYPQRFRTERPYRRPTNDYVERRTYANDHANVPEHVKGQRRLRPAPVCYNCGVTGHISSILVSHLLRNAGPPNHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7M0</accession>
    <name>A0A9D4T7M0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031677"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057122"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06401">
        <property type="entry name" value="PB1_TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034857">
        <property type="entry name" value="PB1_TFG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033512">
        <property type="entry name" value="TFG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335:SF7">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="335" mass="37407" checksum="CAC98147312EC2C0" modified="2023-05-03" version="1">MAPTTTTMAEGTHSQTRHQRADVEASTFPQLDLSGKLIIKAQLGDDIRRIPIHNEDITYDELILMMQRVFRGKLSSNDEVTVKYKDEADGDLITIFDSSDLSFAIQCSRILKLTIFVNHQPVPLEPDESKHIRKELQEIRNVVNRLLDRFEPRHFVTNSSEPEDSAGERAINLLTEICLVSLVQGHHGDRGAELADAVLPGAAYTEKQATYVNTEGRAQQTLPAVPPPGLAREDWKVVRALSEAVGLPLPYNSLSEVRGRMNEVAPHLTCYGERQELLVSDDDAKAGKVELSLQEPIRPQLLALRDFYMTDVISRASPTMAQCVQAVDQQATRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7P4</accession>
    <name>A0A9D4T7P4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Antimicrobial peptide microplusin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_005767</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7P4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028495"/>
    <dbReference type="OrthoDB" id="6478836at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.440:FF:000001">
        <property type="entry name" value="Antimicrobial peptide microplusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.440">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0295">Fungicide</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039480376" description="Antimicrobial peptide microplusin" evidence="13">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7982578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12131" checksum="0DC8FE051443F74C" modified="2023-05-03" version="1">MKAFLICALLATVATVSFAHHLELCKKQDEPLKTELQCIGIHISAEANQSFDKAMKTLGCKDRSCVIRKLCAGNDLEGAMADHFTTAQITEIHDAATTCDPEAGHSHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8B4</accession>
    <name>A0A9D4T8B4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8B4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040260"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7981991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="463" mass="51673" checksum="BB0C1EAF0E7F4BB2" modified="2023-05-03" version="1">MEYTVEGEDIDPAELNDGTWQHPKGSTDPLDALDLQKRFGRKKIDLSEPTAKVGLTGASVPAKRKVRPPRLPRRKPMPRLHEEDYKIVLRPKCAVDLTNIGLAALLESIHSTITIDIMQAEQADQVRVHPIKNTITISTPDQERVDAYRTIGQLRSEKYNIDMPVSAYVPGPDDSVRGVVYKAYTDETDQAIQSELAKKNPQLPIVNARRLGSSKHLVITFAGKDLPRLVRYRCFTSNVYPFRERPEACFNCRKLGHRADVCPLPRPLAPRCRRCGEEHSSPPEGEKPNCTPLCVVCHGKHLTGSRSCKYRFVQSKHTSKGTTSSANSQAETPTATVDRPSRSRQRTQETFRDRSESFPPLSGRSQSRRRSSSRHGSTEHEETSKWLAWESDTSGYQADTTTQGNPQRGASLEARPKRERSASRPRAGQSVSRATQGACRGSKSATQSLPKSPQDPQELISFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8C4</accession>
    <name>A0A9D4T8C4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8C4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="25374" checksum="9309B06E5D061AEC" modified="2023-05-03" version="1">MFLDSSSLGDPDVTAPLGLGTLVVQKPDESKTITNVCEEPSELTHPQLQAHSLPECADGHIAFNETKNVVATTFTRCTHLEDSRTCLCGMLRAAVLKRKGSQYLTTDHQRFDAMECNVSNTQAFSEKVSRDERMKVSPSLFPLPADGISVMKKRALDFTTTAPEESPRPPPETSGVNGEEESERPLDSVEDSAEEGNISIPTKPQKVPDECPDLLPVGSATHTDGGKGAHGATGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBE3</accession>
    <name>A0A9D4TBE3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBE3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035638"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="45844" checksum="7A809D515734EB18" modified="2023-05-03" version="1">MITDASTGIKIRRLVDGRAFNFSEESPSHKEPSSMSLDASRDEAEDDVPYVSSVVAIEDILADNSDAVAKSRNKAEKLVRCELLVDKGCKDETASMSIILQVMQCGTLASAEHSLGVLACKSRFILRDKPPCLLTKAPNSDTGGVAHPRSCMLLEARRGHGIDVSLVVGADATNDMKIHRLLCCSASISSEQSPSLKEFSSLSLDASRVEAQNDVSCASSELSIEDALPNLDVEAKPRNKVDKLVLCDLVVDKGSQEATACHCRTSHASTPQRAQCHMAALWSAGRPQTVSTTEPSKCRLQPGMSIILQVVECGGLASAEHNPGALCCKPQLHQQDKLLRVFTKVDMDSDTGGAEFQAAAFGGYASLLPPSETSTRVAHAQNTVLPGPVAAAFSSSFALRPAAFCVTGCHGCCGIAVPHSTSAKSASGASAATFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBF7</accession>
    <name>A0A9D4TBF7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_019531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBF7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046018"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.140:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041453">
        <property type="entry name" value="Suv3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18114">
        <property type="entry name" value="Suv3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Suv3 N-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent RNA helicase SUV3 DEXQ-box helicase" evidence="11">
        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7984340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="337" mass="37887" checksum="D4D56F7B6586047E" modified="2023-05-03" version="1">MTRRATGGTSRPIHLRATTETACGSLWSLSRRFQYMRLLRDARQKSTKGSVSSLFMPVPVKVSNNPDDINVGEELTTKLKKEDLLKLLNQFSKRPEVIKWSEENGLDARLFHQAFVSFRRYCMESEQLPADLHIIFSDLLQGGRHLDDLVPYFLQHARQIFPHLECMEELQKISDLRHPGNWYPEARAIQRKVIFHAGPTNSGKTHAALGSFHNASTGLYCGPLKMLAVEVFQKTNEKGTPCDLVTGEERRCVLPDGQPAPHVACTVEMAAVHTPYDVAVIDEIQMMRDPQRGWAWTRALLGLAAKELHLCGEAAAIGLVRNLLASLGEELEKTLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDA7</accession>
    <name>A0A9D4TDA7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_025241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000610">
        <property type="protein sequence ID" value="KAH7986035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDA7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030375"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039237168" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="448"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7986035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="601" mass="66360" checksum="6E08CB5A028219BB" modified="2023-05-03" version="1">MEVMTSVRAIAVLFSSALFLQGASSFRDITDDVFGGAQPSVLGAFGDFNSDKLTDLFLASNDSHRLEIWVATGVKPSFHKSEVQCSVPGVITGIMPGDFDGDSIMDVLVTSKDSGSKSDVVDVRIFWGRLRMGVDCANSTHVSDIGWQPLLFDYNGDRIVDLLSARTEEPNSRTVWTFGPSRTPALVALGVGTGALSKPHSNSFVDLNDDMTADLMLTAHSSMEVWYWVGNSTFRGPNRREYPPDAAVKGQSLFVDVDADGDMEHVMPVCLGSVDCKRSAIMVLNGSQWVTWFESFQDTANNTWKFHVDEGQPADLAMPVALRSADVDMDGYPDFLAILEGKLPGQKKVVTRATLLLNTHCPSCPYGRNLVPYWNYGALANFDSAKLAAFFDIDEDGHMDILLTNGTRQNGFHTYALRNQFSDDACFIKVLAVSGLCYTDCPQGHLAYGTNQPGPLVRYRIITSSGYPQESCASQLYQSAHYALQLPYSVFGLGQSPNFVDVLTVALANNESVEHLSVHHQWTQIIPNSQMVVIPYPINDPPRWVNKLFVTPGRQVLLTFIALAGTCVFIVLIIGALHWLEKREDRRMKLQEAHQFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDU8</accession>
    <name>A0A9D4TDU8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000367">
        <property type="protein sequence ID" value="KAH7986576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDU8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051446"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="24659" checksum="94FC178C6061BA64" modified="2023-05-03" version="1">MPLVNWNEATPEDLAGFTADFLREELVRRNLDATGPKEEVINRLLADIAQNRSTTPLLPSPDSSAPSQRPNTTPLPSSFDAAQSTELLTGLLQQLLHVSQRAAAPVQVTTLPDLSASLSTFNGDGRISASHWIEELERTRNLASGTLIATPSPKAPTRALEGLFSLAVKPPSSAPFLDQWDLVKQGGAGSAYLISSATFGAITADQLQAQARAGTRFNLAPATGAVGTLHASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDY0</accession>
    <name>A0A9D4TDY0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000266">
        <property type="protein sequence ID" value="KAH7986814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDY0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="175" mass="18472" checksum="CABC0B0FAB2DF531" modified="2023-05-03" version="1">MQTAAAAAEEAAATIPLAPLPPQSILYPHKKREARAELQDDQKPFASTPAGSEDQTSTDSSSPTSSSSWEHNTPLTSSPFPVTLPKSSWPVSEPESALTDRAANQSNTTGVVCSIPQARRALTPPRRQPVLALACWLTGLPRRASGRREEKRVTSTGKATLDSLAQAGVSQSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TE16</accession>
    <name>A0A9D4TE16_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000782</name>
        <name evidence="2" type="ORF">HPB52_024722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000271">
        <property type="protein sequence ID" value="KAH7986803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TE16"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19612" checksum="A4EA7FAC910B5D0A" modified="2023-05-03" version="1">MRRSGRHRSRRRAANSASGADYALAPQYFARRPLGSAKRAAARAAFPPTRLNSWDSYIGSKTIGSTYVTAKTLRGHTCHISLMESRVHASTTTTSVVRQSSRCSVPPTAVGLHTLGTFTTSLVVQLEVHLSVPGIGKSYLPTLALMQVALDFLRTYSVDRIHVYTDGYTNRTSSTGAVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TEB8</accession>
    <name>A0A9D4TEB8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_024221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000001">
        <property type="protein sequence ID" value="KAH7989031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TEB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043319"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.40">
        <property type="entry name" value="BCL-6 corepressor, PCGF1 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047144">
        <property type="entry name" value="BCOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038227">
        <property type="entry name" value="PUFD_som_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117">
        <property type="entry name" value="AGAP007537-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117:SF9">
        <property type="entry name" value="BCL-6 COREPRESSOR PCGF1 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="4" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="5" id="KW-1053">Target membrane</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7989031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="433" mass="46990" checksum="69E8E28C7809370F" modified="2023-05-03" version="1">MVLGLLWVVMRELHGVRYSIHPKKRKLDSDEQSPPATPSSAPAVSSAPASSEENDAASSTCRRRASRSPERSAVDSSASRRRPQSHSADSVLSSLRPELRQRRMQYHAVRRRKLRSGLDMIRRRKRPASTTAAKLAGRNDRKPFGELNYSAPPDLSKIPLNKSTGETVLHRAARLGHVDLAWCCLESREGGSVESCDVNGQTPLHEAASRGHLRVGRALLQCGADPNACAHNGRRPIHDAVEKGHVEMVRLLLSYGADATLTTGSGFLSDMAGESIDGSPVLAWHFAGTASFMDPKDTGFDILAGAPAEDSGDDMLFQVSESAQIATYRLSPHLAGTSEQSCSECVRLDDVLQRLRISAEEFRQRFPAVEILALAPHELRAKTTTPWLDAEMAESSGTPEASSPPSPPASPVQALRFDATVRSILGLHNPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPE7</accession>
    <name>A0A9D4YPE7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">adenosylhomocysteinase</fullName>
            <ecNumber evidence="8">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_010814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZC3H15/TMA46 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="8"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047933"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7983310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="431" mass="48293" checksum="F50A37E6595168AC" modified="2023-05-03" version="1">MKKEGTLKVPCINVNDSVTKSKFDNLYGCRESLADGIKRATDIMLAGKVACVAGFGDVGKGCAQSLRGFGCRVLVTEIDPINALQAAMEGYEVTTMEDAASKASIFVTATGCRDIVRGEHFEKMRNDAIVCNIGHFDIEIDVKWLEKNAVEKIEIKPQVDRYRLKNGNHIIVLAQGRLVNLGCAMGHPSFVMSSSFTNQVLAQIELWTKSDKYKICKHFLDALEQNKYGWFWECPNGGQKCHYRHAVPPGFVLKKNKKNIDEVKAEDTLTIEDLIETERAKLGGNLPRITLEIFLAWKKAKIREKQDSEQKERDRKRDEFKAGRSIGLSGRDMFTFRPELAEDDGQDEEGEEAYDLSRLEGEEDNAEVVREITLENLMAESLKAGDLAAAAASPIEASMATSVPIDEKLFEDDDLEDLEELEDELEELEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQQ2</accession>
    <name>A0A9D4YQQ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039119"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="25114" checksum="245CBBF1B16CD96D" modified="2023-05-03" version="1">MSGANFTEEWLVQSGARIRAPLARSPSAKAAAAAAPAALLKNRSTVRRPDQKKDTIGTMRTNATATQHRSPHPGLLRAPGLLRVVQMPSMLLLLLAAAFMAHTAVADPSIGDVIGQIRERAAATTEDAGTTTPAPPNKTRNERILEQWSKFELNLQDLVDSVIRKVLPTVIRRSSELEVSPDCRDALLKVVFGIRQLKRWAFQWGPVLCDLANTELSVSNAILAVAAEEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRJ2</accession>
    <name>A0A9D4YRJ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_025436</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010000747">
        <property type="protein sequence ID" value="KAH7985726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029122"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000006">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="236"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="415"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="596"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="476"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7985726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="825" mass="92378" checksum="30C524228A0F27C4" modified="2023-05-03" version="1">MLSKTTVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGKLDVNEEDPFELFIAATNIRYCYYHETHKILGNTYGMLVLQDFEAMTPNILARTIETIEGGGLVVLLLQSITSLRQLYTLTMDVHSRYRTEAHKDVVGRFNERFILSLSSCESCLVVDDQLNILPVSSHAANITPVSRAAEDQEAQELSELKESLQDTQPLGVLINCCSTCDQAQAVLKFVDAITEKTFRTTVAVTAARGRGKSAALGLAVAGAVAFGYSNIFVTAPSPENLKTLFEFVLKGFDALKYEEHQDYEVVQSTNPELNKAVVRVTVSHEDHRQVIQYVHPSDAHLLGQAELLVIDEAAAIPLPLIQKLLGPYLVFLSSTINGYEGTGRSLSLKLIQQLRQQSVVASNENSKSVGVHPNRRLYHKCSVSCKVCYEGGISKSSVSDSFARGRRAHGDLIPWTVSQQFQDEEFAGLAGARVVRIATHPEYQRMGYGLRALELLTEYYLGNIPSLEEKPDTDLDSVPLAEEDGEGIERLEPRKALPPLLLKLSEKRAEQLDYLGVSYGLTADLLKFWKKAGYIPVYVRQTPNDLTGEHSCIMLKCLQESAQWLPELWKDFKRRFLFLLGYQFRELAPATALSVLRNPVDDAIPATALTLEEVQRLFSVYDIKRLELYSQNLVDHHLITDLLPTLAQQYFLKTLGDMHLSAVQSAILLSLGLQHSTADALAKVLDLPCTQLLGLFNRVMRKCSQFLRGVLEKTLDEALPRTTGAAANLQPVLQSLNEELAGAAKEIEDRQKRELKKLQQMDLSQYSIKGSESEWKSALEQPGKQLVSIKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB65</accession>
    <name>A0A9D4PB65_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039514"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11260" checksum="7D9990A5C7B713E0" modified="2023-05-03" version="1">MYGFRQHLGTQDVLIQLQELVVKKTTRKAPQGILALDLKGAFDNVSYASVLRNLNKTRCGRKTFAYTTDFLTRRTATIRIGEEKSEPVELGDRGTPQGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC65</accession>
    <name>A0A9D4PC65_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC65"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001166">
        <property type="entry name" value="Hyperglycemic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="173" mass="19101" checksum="DD838CC29B7C4B8D" modified="2023-05-03" version="1">MFEALRAMGVGGDGNIARCGRVAETQNILPCRRECPIGHFSGGTTLPDQSGELVAVAGLVMSASFLVAPVRCLAATLLVCSLVVLTLPSVCTARNLHKRSFLELGCRGNFEQSYLARLERVCEECYQLYRDPEAYNRCRMSCFKNEDFGLCAEALLLKDEMTGLRRMVNYVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD30</accession>
    <name>A0A9D4PD30_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044946"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10434" checksum="23EB1EDD80573DE0" modified="2023-05-03" version="1">MKVCSAHFVASDFFWGTIEPHVWEPCVKRLKKNAMPSQCLPPDTQYKIRSSRQKASPQGSKRAYEEYSTAMSRLIAGGFCSFHMPGHIILTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE03</accession>
    <name>A0A9D4PE03_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE03"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058393"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="165" mass="18612" checksum="9C1C6CAC4B96A7E3" modified="2023-05-03" version="1">MQVHTEFRRPGESLTVTDIFKGHTLLRAHSNDSEQSAEEALGDAKAVALYFAAYWCPPCFEFTIVLAHEYDEMKEESAKPVEIVFVTADRTEEDMLRFMAHVHGPWYAVKFDDKEFRNALFDKYRVSGLPDLVVIKRDGTVITADGVADIKYDGSKAFAKWAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE12</accession>
    <name>A0A9D4PE12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_023431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033061"/>
    <dbReference type="OMA" id="YFFFTCA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF243">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-7 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7936446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="363" mass="41073" checksum="CA569957043929FD" modified="2023-05-03" version="1">MAPPVLCCLSEEAKLQRRVNEQIERQLSRERFEAGRESKFLLLGPEEAGKTTFLKQIRLIQEGDAREDRAEHVRSVYQALLGAMQRIVRAMDALGIAYSNPSNAESAMMLASVRCETLEPPLTEPVSEALRRLWEDAGVRECYARRAEYGGLPPFLPDVQRVTRPGYVPSREDYLRVRTPSRGVLEYAFELDDHPVRLVDVGEQRSEPKKWIHCFEDVSAVIFVAPLSDYDDPDKMNRARALFSTIASSPWFAESHLLLLLNKKDLLEQKIRRSPLGAYFSAYRGPPGDAKAARDFLRRSFAELKPERPVYYFFTCAIDTDDVKYVLPTLREIACLRSCPTRGRQPSDASTASNAAAAFQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEY9</accession>
    <name>A0A9D4PEY9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEY9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="537" mass="59793" checksum="A9F66F36FD380F97" modified="2023-05-03" version="1">MEASARTTVIVDNEMRVQVQGEEITPEEYHNEAGWTLAGERMSRLRRRAPASGMPDGSGGSQASPKSKFNKNVRASVIKAARMPAMPLEESKIVVRPRGGLDIVKTAPPPSPRPYSPRPRSRARESAADTICPNTQQNIMVVSTPNENNAARYATIHEISIQGKLYEVSAYRTAPHDTVKGVIKGIPTDANAEELDRNIVNERNPLAVGAKRIGSTTSAIVVFQGPKVPNFVRYGVTLIPCHLYRKQIDVCHQCGRVGHRKDVCPTPTIKTCLACGLANPKEDHSCTPKCKLCGGEHSTGDRTCKAKYKMPYVVRKRQWVRRQAELQLLPESDFPPLDKPSAVQKSRTPSKNRAPKSRDSSKKRSPSHERVGWVDAAKGNNTRSAQKITEAAKKDDMNKVREANETLRQENAALRTTINNLSREIAEIRKLLLCNNESPQRPTPSSRETEETSTKNQEAAVEEPAQKKRAIEAPRKQKENDRNENLEAKFEARFTKLEELLTANIAAVTAMKQTVDNYQAENINRFAYIERTLQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFU5</accession>
    <name>A0A9D4PFU5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFU5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048586"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF516">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7939707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13164" checksum="0E404E5533ABF587" modified="2023-05-03" version="1">MLPSAGGPYEFVSVAAESMGRAGDVISFLFAWIFVLLDPAALAIHGLTFTSYALSGVYGTCTPPRVVTALVTVGVIELAAAVNTFSLKVSMKLQNLLFVIKITILLAIIFTGIVWCFRGKYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHQ5</accession>
    <name>A0A9D4PHQ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_019785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHQ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050643"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 FCCH" evidence="8">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 four-helix bundle" evidence="9">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7939964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="408" mass="44568" checksum="E1E8AF262245E301" modified="2023-05-03" version="1">MIHEEEEKKYEHGIAPVLARITRGDMAQHGSSQDQPAIDEGLYSRQLYVLGHDAMQRMARSDVLICGMRGLGVEIAKNIILSGVKSVTIHDQGDCTLADLSSQFYLNEDCLGKNRAKACVDSLAELNSYVAVTAHTEPLTNDFLKRFRVVVLTDTPLKEQLSISAFTHANNIALVVADTRGLCGQIFCDFGENFRVLDTNGERPISVLLASISKDNESVVTCLDEVRHGLEDGDFVAFSEVDGMTEINECLPMKVKVLGPFTFSVGDTTRFKDCGRGGVATQIKMPKDIEFKPLKESIVSPVFLSSSFADPDRPALLHVGFQALHAFQKKHSRLPRPWNKEDAAEVVRMAKAKNASMSSPLASLDEAVLTTMACVSTGSLCPMQAAIGGIAAQEIMKARTMPAKFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIB5</accession>
    <name>A0A9D4PIB5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIB5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048304"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="308" mass="33952" checksum="A0B432C0E8CDA772" modified="2023-05-03" version="1">MAPVRLKEFCPSYFAELVGPTRARYEAKISMCDGVDPYTLCAGTDTTTDVELLPVTTHADIVNYLVLWTNHVSLTEMKAYKSLEAHNYFTSGRVSGVTAKRLPSKRVIVLSEDHLCPPSVRERVLECLGETLYFDEMASSFTRLQQDARDFIALLRHFQMPLGPEFPANGFAAGSAQDSCDVDVDGAGELMPVALCDTLRGVRFADYVEVDTGASVCGALTDEDIIDQVAGAQPVAEEPQGEEDEEDEAPVRPSVSAVMEALNVARLFFSFEEGEEDSLRRVRALEQRAAAVAFREKKQMVITDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIL4</accession>
    <name>A0A9D4PIL4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIL4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031833"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="205" mass="23831" checksum="3F4C7B2B62FD7C07" modified="2023-05-03" version="1">MIEYAQENCAHEKIVYDYLDIDNDVSAFSKKYGAFQRVYSFKTLHWSKDLHRSLDNIAKLMTPGGECLLYFLARKFLFESFKELSRLERWTKYSDVLLRAVPKSHDIVDRRGQQEYLYSALSSAGLIPYTAEVLVSESSVQKENPVTKPIYQIANPLYSLLNDEERPAFVDTLSRHLNEWQDSYLERSGQNVFSAFLVHAVKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIP1</accession>
    <name>A0A9D4PIP1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIP1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10264" checksum="EDB9336AE3189B41" modified="2023-05-03" version="1">MPLAMIASACRFRANGASPFVSALLTAMVAVSALLSLSRGQCLSYACFKQCRDSGRGPGKCLSHYHNSVRYMGCACSDTIDYHLADEQYFGTLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJE0</accession>
    <name>A0A9D4PJE0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJE0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057469"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="21688" checksum="DAE9072DBFE1A7B1" modified="2023-05-03" version="1">MELRHLPGSDDDRVFTEQSGSPHSTAEATEKLANVMKEYFACLENNNNDAQVLSAKGTEALLASVKNASASASAHYNLGIFYETGMSNFTKDLEKAAMHYKAAAHMGHPKATYNLGVMYVKGHGSADIGLSLLKKASSMGVPQAMTFVAYKYLEEGHIDKAEPLLKEAVAANDPNAALYLNLCRERGTDEVQDRKEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKU1</accession>
    <name>A0A9D4PKU1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKU1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040113"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10989" checksum="0475EC4B55F46B42" modified="2023-05-03" version="1">MGTFSRHGGLLLDEIKLSEHLNGEAAGDIEGFADLRDYTTSEHKNVLADHGLVVLFEPYTVKLIKDEVTVFFSKNILHEENLPILKDPAVSLTVAAWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKW9</accession>
    <name>A0A9D4PKW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS22-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034021"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042320">
        <property type="entry name" value="MMS22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029424">
        <property type="entry name" value="MMS22L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547:SF1">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14911">
        <property type="entry name" value="MMS22L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS22-like C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15010" checksum="308B380D321CCD1E" modified="2023-05-03" version="1">MADCVLPRLLDSLILPGALYAGKPIPQAQLAAIKQHLPLFICGLLSLNPQTDAYIERKLKDIVVHYLPLFPTQTQSSIHHTGEHPLLATLESCGGACRAAAERRAAYVGFLLDFIQKHFVARKTVSGTHLNQVKVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLV2</accession>
    <name>A0A9D4PLV2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_021971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLV2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057520"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12673" checksum="A5566B48771A9F94" modified="2023-05-03" version="1">MLAVGGRVNWLDGNEDGRDDVPGLLFLECSGCSRNSTPAEALTTSNAHTGTSDRPPEQRAEPRKERTAFSRGQVEALEAEFSLRNYLTRLRRYEIALALDLTERQVRVARPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN01</accession>
    <name>A0A9D4PN01_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051483"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052237">
        <property type="entry name" value="Ataxin-7-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117">
        <property type="entry name" value="ATAXIN 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117:SF24">
        <property type="entry name" value="SCA7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="825" mass="83010" checksum="6F863A4392924241" modified="2023-05-03" version="1">MAAPNSVSATEGQSWNSWAETIGFRSPEKQRHGSIGNFGRGDHTADPSVLHPSGGGKSSGHSSSSSSSSSSSSSTSSSSAPRHSGGQAGRPSSTAKAPAGSSLSGRHSGAAERLKRNNHTMAPVVRVERMPLPRQPDGTAARNCSPGREKELPSPQQPPPLTPGGLGLLSGPGPGQANHLMPDASAGSASAVAVATTPAVAPAPVRKVPSGGASAAGTGSSHGKKIQRERKLLPCKDREYDPNKHCGVLIGDSGKPCTRSLTCKTHSLTLRRAVAGRRKNFDELLSEHRATKEAALNASKSAHPASSSASSVTDGVTASPAPSPLSSSHHTGGPSSTNVAASSAGKHGCPGEALPGNRTSGGSGHVLVRASGGGGSKQSVLSKGSSTAASSSGAPAKQDQHAKRRLCVVGSRLPNAAGSGYTSSKDEHQRSADLYSLGSVAVVETPVAVATSQTSVPHTLATAVRSSPHPTGTSGGTVSTQAVPTANAAAHPVSKATHPSKQAAPSRSAASNCGGSSSGNVLLSSGPRKKKPVSSTITAVVTSSTSSLVSSLAAVSSMATGTPASSVASAVQVPLSGTSVTFPFRTHLGALSRLQVSGQGVVPKDGGTAMLVTTADVLNGQVNSSGLLHSVKISKPAVATTLLQCRPVDEKAAKPAAGPTLLKARKPNPPASGRTSSTAPGMRNHHQPPISQGLALPELLAAPQVPVPTASQLPNGMPTVLGQSKLFSVPNHSVQGVLDGTTYHQAQLVAKVLPDTASSVMTGSTATSLPASMAKQQLYQQVLAGQVQAQLVPTTLKLPLLLPNDERRHRPQQPHLKVPGGSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN12</accession>
    <name>A0A9D4PN12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041227"/>
    <dbReference type="OMA" id="FADCVLG"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF23">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="310" mass="33844" checksum="E73C3DBD8E1E3AF7" modified="2023-05-03" version="1">MPDAKEVLVTGGAGYVGSCLVPLLLDRGWRVTVYDTFSYGLGPLLPVAHRVRLIRGDVRDGAALASALKGVGAVVHLAAIVGYPACSRDPELAEDVNVGGTRTLLEQLSPSQRIVFASTGSCYGAVTDGLCTEETPVSPLSVYGRTKAESEKLVLKSGGVALRLATVFGVSPRMRVDLLANDLSRRALQDGELEVYEPHFWRTFLHVRDAARAFVLALDRYDEMRGRAFNVGDDTLNVTKAKLARLICERAGDVRLVLAESGRDQDRRDYRVSHARIRELGFRASISLEKGVDELIRLLPLMAPHELCMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNA0</accession>
    <name>A0A9D4PNA0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNA0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036829"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18702" checksum="947179D829CD4ED9" modified="2023-05-03" version="1">MVVTSPQLNFKWEINTRGDPILCPPDYIAAILALAVAVQAVPLRFNAEGDLDTAAQTFRAVAASDDPLSQPIPYSFKHESSTDEGTHTHEETGDGNGRVSGSYTLTLADGRQRTVRYTADETGFHPEITTNEQGTESNSPADTSLTSSALSGPDAAHAAEPERLRLLASGGFKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNJ3</accession>
    <name>A0A9D4PNJ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_017327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNJ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028158"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7947980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="12469" checksum="C369036426BEA151" modified="2023-05-03" version="1">MLLFCPTCSNILIVQEAFNSYRFACNTCPYVHNIKQKMSNRKYPRLKDVDDVLGGAAAWENVDSTEEKCPKCSHGRAYFMQIQTRSADEPMTTFYKCCSPQCGHQWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPE5</accession>
    <name>A0A9D4PPE5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_020849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055943"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056532"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7948364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19377" checksum="3E9D90D101240C12" modified="2023-05-03" version="1">MPTVTGRLEGNLVTVLRDTGCSTVVVKRSLVPDAKLTGNTRIIRLLDRSEKCLPEADVFIDSPFFRGVARAVCMENPLYDVILGNIKGRLLQLIQQGQLSLEWVRLLVLDEADQLLGEGFQEDLRKLWALLPKRRQVVATSATYSPEVARILEEELLRNPMVVRLGADTPALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQK4</accession>
    <name>A0A9D4PQK4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQK4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="258" mass="27098" checksum="FE98C8BCC6A1E77F" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMQDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTPSAHGPSDVPAICTSSPTSMAHDTSPTSGSTTATSPHALEPAIDTDIVTFAVRPPIAEASPAMSNEPAFSTSTLCASCQQELPSSSKSPAADVQAHNQLRPNVRDAATMTENPEDHPPCLPQRTPRGSSALYTADYGAAASSNVPPPTPLPAPSPHQLRRPPIPATFAPTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQV8</accession>
    <name>A0A9D4PQV8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQV8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038537"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="344" mass="37568" checksum="22BE5A217B4AD3D1" modified="2023-05-03" version="1">MGRALYYVSYARYAISDQVLADVEDVGQNIEIALRDRVKAISAWRAAKPASTFSVAGLVERLSAMTKAGAGAIDPEYANFPQMDENIMNNMPLAVRGYRSVRRTNDSVVAVVVRGTVRFFYFAGDHVQLHPIIFQEPFYSGDTSPAIACGTLGTDISYALATRLFDVVLGSGDELRSSLEPNLTCLFGSETVLGDEVTTKAVVADQDSGDTKAEALVTSPPCDKETEKTTVTSKRPKTAGRRPLRPFNLGINIPYFFNMRLLTGPGGTGLGLNVPAILNFQLDAAHRRRPGLLLSLFGNRENLFNRRKRPGNPLFSSPLRPPFTQAPEQDNAIDIKRKPAQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRL8</accession>
    <name>A0A9D4PRL8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055628"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="261" mass="29930" checksum="BFB01FCE1860E31E" modified="2023-05-03" version="1">MGPPPFFPRERARRLFSGCNFKFGNPIHIFFLRLRVSSKLRPLPLALRQKDASELRRLQDDDVIIRGRRPRSRLHINNEVLPAQAIRDGPAVQCHSAPAEVQPQIPAAQDYGLLVPDIARTASLVHKASYRDYRLHQRRYHCRLLQEVLVSRKSAARRLSIATRIRVALVCSVATFCQKVTMTGNYLAEAVDGSIPTKWQTSPQRLWSLQELLLSQNSRKVSPTTELGYHKQSFHREDVLFHCEKVAKQDSLWTGILHDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRQ2</accession>
    <name>A0A9D4PRQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_011143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040393"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049813"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCA7" evidence="12">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7951658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="552" mass="61259" checksum="3A0281125361894A" modified="2023-05-03" version="1">MQQPHLENASTTANAPTSSKVLDEQSMSIFEELVDDVILGACFEVHRSVKLGIFFLDEATDDEKKYEIVDEVGLDVFGQVPLKKQFECVCPNCQRNLAASRFAPHLEKCMGMGRNSSRIASKRIANTGRAESDVDDYDNDSDWNYLSDRKPAKKRKDRNCPRKIKGKPKNGEQASTSSASGETSNSISTYESLSMEERKALLTQMCGVISEHTKKMCTRSQRCPQHTDEQRKAVRQFLLNQGAGSSTLSADASDEVHIDVDTFDEADNHALHDTIGQLWETVSSTNSSPADGSFQGNNVFTMFNSAVVTLTVLLAGQCVLAESPDSDLEKLRITVAKHDRVIVIFTQECCTCTECVEVEQILNAKQEELNDYYGVGVVKVVSKPKVEERYGITSRPAIVFFRQSVPALFEGRHDPDSIMEWIGQSLEPAVKALDDESFEHLTQAATGATTGNWLVVFHTDKCVKQDAATGVLEGLSSKVKGTTNVAKVDIDRSPGLVERFSIKECPTILFFRLGKMYKYNLKKLEIKSLKNFLDGLYKNMKAHPVPVPQTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRX6</accession>
    <name>A0A9D4PRX6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_015625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRX6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047775"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7951945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15134" checksum="24C1ED86906EFDCB" modified="2023-05-03" version="1">MASSGRDWLGNLPLQTMAASSSSRSATRRAEMPTDLAVYSVENFEPRPPQELVCTVCRGVYREPVECPCRHVFCSICIHGWLAYSASPGSGSCPLCRREMTVSQVVPVVPLVNNMIAHLTVRCPNREAGCIAKVRHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRX7</accession>
    <name>A0A9D4PRX7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex I-49kD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRX7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056979"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="8">
        <location>
            <begin position="191"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7952017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="461" mass="52250" checksum="8A099A340A98B09A" modified="2023-05-03" version="1">MASVLTAAARLLRPKLPAAVPKFGGSLFFARGAQWCPDDDFIKDMSGLYFAPDEDQKKITPLPPNDYLEGPEKHVRNMQINFGPQHPAAHGVLRLVLELEGETVVRADPHIGLLHRGTEKLMEYKTYTQALPYMDRLDYVSMMANEQCYSLAVEKLLNIDIPKRAKYIRVLFGEITRILNHIMAIGTHCLDIGGLTPFFWLFEEREKLMEFYERVSGARMHAAYVRPGGVAQDMPLGLMDDIYDWATKFSERLDEVEDLLTGNRIWKQRTVDIGIISAENALDWGCSGVMLRGSGIKWDLRKTQPYDSYEDFEFDVPIGLKGDCYDRYLCRMEEMRQSLNIIYQALNKMPPGPVKTDDNKCVPPSREEMKTSMEALIHHFKLFTEGYQVPPGVTYTAVEAPKGEFGLYMISDGSSRPYRCKIKAPGFAHLSALDFIGKNHMLADIVAIIGTLDIVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS02</accession>
    <name>A0A9D4PS02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS02"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042801"/>
    <dbReference type="OMA" id="NYYGTQD"/>
    <dbReference type="OrthoDB" id="6503434at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="222"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7951346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="799" mass="88419" checksum="3E4E09368A1E8B32" modified="2023-05-03" version="1">MEENTADREASTADIDASRTGEASDVEGSVRKKGKHRRRSKKSSKDAAAKTDEAKQAGENQGRSSQEPGPSDRSSSSKNETTEKSSGSRRRKKRSRGNSVSEQPPPAAAEEAQDRKDGDIAANVPSSTPSVAKVEAPPAGPEETAPRQYAAESPEEKRQRYQIFNDVTKTVALIASLAIVIIIIILGPNGTIPSDHPTCTTEGCTLYAQRLLASLNASAADPCYNFKEFVCDGWKRRNAYSVRQNMTVTALDALTELAHSAHVPLKGQTTAQKGLAFFRSCDAVLKKDRNELATVKKMLAEAKIEWPRRPTQPDVLYTLFYSSIRLRWSPIFNIEIETTDTYATRVFLMPHEDFDLVARKYTSLKKAEATERRAYFDVLGDEFGASAADQTVVSFKEVENSGQVMLEPLLDALAKERKPTAISTAWLYRPGADPSKARWQSVLASYGVKGNETVIYETETLPFVTEFFNLWARYGEAMIEVLVSWCTVQVAALYANQRLVANYYGTQDAAMLRYGAFCLSKAYLIAGFSVFAPYVGEEVTQPDRRDVEDIALSVRRAFHARLMTWEHYEPERTVVGDWDSVSFVFRPFDGEDMGVSNVTRSYPDMGESLAENWRNAAVPLEIIRSDKAYAALKSLKLHVLLDYDFLLLPFAAAFPYYHPNATRPMKYGGVGKEVALALSEAFLDTYARFDDAKKAIDSASICMTGAPDSHSNLEAIALHALFDAFNNASSDKDVRLPGLEDYTASQIFFIASCYAKCSGSSGDTDEDCNVAFRYVSAFADAFKCPPLTYMNPADPCHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSB7</accession>
    <name>A0A9D4PSB7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051063"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="262" mass="29825" checksum="B5F33FBACD14591A" modified="2023-05-03" version="1">MASADYGDTWEDNSLGADDRLYRRHQPYEEMHNDIGDSDQLLMPFLPENTVGLHYTGFPFIEDALHLQRQSSREDAFSDYLRALVASRERKRSVFLSQSWQPGGHPASPVLRRQHQTPRQQPRRVSQEPAPSSPEVASGSGPTDRKSNERVRPVNYRHHPPVPFIFSSKGWHPGGRKRNFFFSRGWGPGGRPLTLRAEYFKKKPPASHAGWRRWLAQGRAAMGGGHGNSDSSATVKVTSTRHGHRPCRANCWRIPHLFGPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTI0</accession>
    <name>A0A9D4PTI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interferon alpha-inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043611"/>
    <dbReference type="OMA" id="KNSANIC"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7952144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="8378" checksum="0CC8921B56CF9711" modified="2023-05-03" version="1">MADPATLVAVGGAVVGAAGALVAAPAILAAAGFGAAGVAAGSFAAAAQATMGGFVAKGSMFAICQSWGAAGLPLAAKGVAAAAGAWLGYNVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU60</accession>
    <name>A0A9D4PU60_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rab5 GDP/GTP exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_003282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU60"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038349"/>
    <dbReference type="OMA" id="GHYQANV"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="236"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7955707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65081" checksum="F9291C4FB2F4B087" modified="2023-05-03" version="1">MAESRKLGSLLQEMNRDLKCRKGCSFYGNPEWDGYCSQCYKELRAAQAAAAAPASPLGTQPARRLSRSASESPEGYPSASQPGLIEPSPFSRFAEKKRQHAEKRTKTLRSIIRRSNTVKESVSSKDFQLSSLESNPAAKELKDFLRDLKESAACDVIKQVRAAVDRIHKMSRDQSIDELSNQVQDFYQKMHERFETHTHYQGLEPDQVERLMDLTENYLMSLTYKSIFEFISTADEEKDLAIQRRIRSLSWVAARHLELELDDRQTPVRDVIDRAITHIIELDSRHSPREKLACVVRCSQQLFEALRMGPQGPQPASADEFLPAMVYVVLRANPPLLHSNIKYVTRFSAPSRLLSGEAGYYFTNLCCAVSFIENLTAESLNLPAEEFERYVTGEAVPPGGYDQGASEGLRLMYSNLALLSDMRQRQELLAEGTKLLRGRINEFRETVSREVEQALTQAPLAPCSYKVPADLDVRFVPAFLRDVVLRELDDGDSLLLQLDTPPPAPAASTDSSSTVAPLEDVQRVLLASGDPMSPDTMEACLPPPLQPVIVGSTTETQAQSLESTLPSAGDISCTMPVTETTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWB8</accession>
    <name>A0A9D4PWB8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052918"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="230" mass="25701" checksum="71B2B5907469DE7F" modified="2023-05-03" version="1">MEENKENRSPHGTFPEARSAVILEDRLTYLCFCDQFARSTTVQVSSLHRDEAPIVKKHSRHTSERKSAARRLVIATRIRVALVCSVTTLSPESLAARLYASHACANISEHAGDPSAGPGKAGLFTRQPGTLSHYELEQMLAHDLSWSRQFDRVAQCSYVVNGDQWVGFEDDVLLQSKAHLLLFSRGIAVWDICMDDFRGTFGRPLLARARDILLRNHTFGHSLRAKGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWR1</accession>
    <name>A0A9D4PWR1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWR1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030605"/>
    <dbReference type="OMA" id="GENTNFY"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000005">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7955788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="352" mass="40371" checksum="83BB7655AFDDD400" modified="2023-05-03" version="1">MTMSSKRVQFDEMEEELLGKEGADEGVKKKFKNSLDSDEEDDEVEDKKYNLLNPDDVEGQEDKTIEYDGNIKITPFNMEDEMEDGHFDKDGMFIFNRDKPEIRDNWLDNIDWVKVQPTKQVAEDSRGTEDSEDEDSVDTLALYGDMLEIMQPGETVLSCIKRLGGGKRDSTINRWKKKKQEQTEPDSTKDVAPKESLLRMTELADRLVSTGDMDIYQQTYERLKFLREHKQQAKEAKAATTAVEGSSFDMFADDADSTQATEPSPAKKEKAGTESKSEGAEPVSSSVGDDEVMWEFKWEESDDAPVYGLHTSAQMLQWVQEGYFQDGVWVRKAHETDRPFYSSRRIDFELYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ30</accession>
    <name>A0A9D4PZ30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ30"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="73" mass="8360" checksum="98B04D96DD4F3E90" modified="2023-05-03" version="1">MTLHERLEVGTGSQHVGSQLNSKQQILWSLQELLLSQNSHKVNPTAELGYHKQPLHREEALFRCEEVAEQDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0C8</accession>
    <name>A0A9D4Q0C8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron-sulfur cluster assembly 1 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0C8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054891"/>
    <dbReference type="OMA" id="LYIYGMQ"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="13965" checksum="69D8E44E2140C5D9" modified="2023-05-03" version="1">MASKLTATVRAVGSKRLSVPQRAALVLTKAAVDRVRTLLATKRDVIGLRVGVKHRGCNGLTYVLDYATEKGKLDVEVQQDGVKVFIDSKAQLTLLGTEMDYVETELSSEFVFNNPNVKGTCGCGESFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q111</accession>
    <name>A0A9D4Q111_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_013883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q111"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035493"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041416"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25998" checksum="9E9A00C2CA73CBC1" modified="2023-05-03" version="1">MQPPRTATVQPLRTTTATPGSPEVAHTSAREADYVPIDGEVHLGKGITIPEGLYSRLMSTKSETRFVHGIGEEEMMRVLRDKRSGICMSSGSFVSTGSQVSVLAPASSKRLSCHWFTGTPDPAHSVFKPFIFCDHVLPSRHTVSPVFEHDPAKTKPRFEFTVDRRHTLYRHHEQALKAMQAGSATGKELHALMTELEAKCIREVDSYLDNPGSTQELQELFKDVVESEIKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3D3</accession>
    <name>A0A9D4Q3D3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3D3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22546" checksum="4C46776134D1FC89" modified="2023-05-03" version="1">MEVEVEGVQISLEEWTDDSWTPPQGFRAQAKRHQALKQQAQMKDAQASKAPQVLLTPRPPPELKRLPLPRLPSHTYHIVGRPKTPIDLTRTSPGDLQTALLKAASLPDLDPANRDQIRIHPRNNTFTVSVATTDRAIAYQRITSVLLEDDRQIEVHIPGTAPTCALNLGADAARVAEKTTSRHHKERHQHAKRAVLSVKEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4M0</accession>
    <name>A0A9D4Q4M0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051144"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="273" mass="30444" checksum="6D1830E1375E614D" modified="2023-05-03" version="1">MLVLMRLRLGLDGLGLAYRLSDKALTKACGVLEKFSPGRSVMADRGFTIEEECKQHSLRLKIPPFLGGRPQLPEADETDTRLIASETHITPKEVRQKMENLNKHYRKMRRCGTTTGSKVVEWPYYWLLHSFLGTLPVNDSSLVEESVEVPDVNETPEGAHVLAEFNEVVNEDAASVEDSSTTSLQDEGATPAAGSSDSSTPKDPGTSRKRKRPPTALQEILELQKQAEERCANLAQQTVAMQQQMVQLQKESNETQKDILTVLKSYFEGRNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4Z7</accession>
    <name>A0A9D4Q4Z7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4Z7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051635"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039533621" evidence="2">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="34602" checksum="ADCC872AA3DE1E85" modified="2023-05-03" version="1">MVVTTRRLPCGALLSCCLLFVRALAGEPSVSYYDGLNETGPWDVFFNGTTLVLSPVNASVADSGGEDERLSSLDERYDLLPLQNDSAPLLEYREPFQPLSSVDDGEARKTVYLLGLFELTGSCEAARGGRAERAAARLAIRHVNERNVVPGHRLEMYYNDTRTQGLSEEYVKEEDRPVTRAGEASRGVRQSWCDGADKLDDAKGNDGGIAEKGLLLSRNRVEALIGLSASLRQRRGEDAEKLQGLFLLSEKFLATRRSEDGWAARKRTRSHRNVVTRVHLQDERAPVDPNFNAPPVPSHRRDGVEVHGSEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5T8</accession>
    <name>A0A9D4Q5T8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5T8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042614"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7968554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="30736" checksum="B2285411F4B3ED9B" modified="2023-05-03" version="1">MRHFKKAVSSCRAELHGVDLNMPVLTTGSWPLAAVTQQSKIPQRTSHPRLKWRAHRPASFIRELTYVIQVTTYQMCVLMLFNHHDAISYQDMASETNTPASNEIEKDHTFAVNDVFTSSLQKVKIESTPSKKNAAPKQTEAPVNLDDDRKYELEAAIREGLPSRLRGSHARKTLSLENLVEATKLLQTRYTPSPAAFRDRVDALIQKEYLERAGEDPESDSAHLSSAPAEINLSAAISRRVLKLCLSTGNLRNNGNKEKRGRARKHAMAAPTRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6I4</accession>
    <name>A0A9D4Q6I4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6I4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030300"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9517" checksum="314420AD68552ED9" modified="2023-05-03" version="1">MVNGKDAQLPSFWVPSLTPSAKKDKAAKPRNVVLCPMSGNPIKAKDLIPIKFTPVVDPDEKASLITKKASMSGFIILCGRSSNGKMCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6I9</accession>
    <name>A0A9D4Q6I9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6I9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031934"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22507" checksum="8D55E04CD7C1E4D9" modified="2023-05-03" version="1">MQRSRGLTLEEITRILEEDDQDVSAIYIEPPEATIYSDEDSADEDSGGLIDNLSSRQLRAGAETDLADGRRIGGCDSDEDEGEDEQQGDKPPNISSGAGDESAGANLASSINLHLLRHLKEKNYEATGTVRQNRVPKECPIARPDFIKRKTRGYEEHALSDDGIIIVRWMDNSVKHRARRRAHVICRQVFPCTEEEDQSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6R2</accession>
    <name>A0A9D4Q6R2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6R2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053811"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="297" mass="32152" checksum="0993906FA31C765F" modified="2023-05-03" version="1">MEGAEVLVPVAPPTTPPTGPLDAGRRTCPWGNASSRPQENVSLADVMSEQLARALENEELVTSAQGDHPAVPYEAVAAAEVFASPEDCSDDHALALLLQAEYDREHDTVLGVEERKFNGKSKVSVSFDNYRRAREPVLSDSEDEDEDGLDGGLGFGGARHWDSFERDQRTAQAIGRSGVARQPGGGFTTKHDATVCGRRNACRVMELPPGISTGDGGGFDMRLSNHVYNSLKVHSAQEGRRAARLHDKREKATAEQSLDPNTRLVLYKLLNREILNEMNGCISTGKESCVFYAAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6R6</accession>
    <name>A0A9D4Q6R6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6R6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030330"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="38094" checksum="34CAC8E178E5F40D" modified="2023-05-03" version="1">MAKRTEKTTGASDLVQCGECTRWCYLDETAFTSLADAEEASFVCKLCEKVKAAAQRMESCIEELKGELKVERVKRIELQAQLGEARERGEATASLVEQMEADLRKEQERRAELEERVKVLMALDPGSERGEAKGEGSTDSQAGKEVGAGDSMEEASRSYSDVARQSGGAGSTGSGLGAASREHTADGELAGANRSATISSWKRTIGAVEEGVFTTVKADRRVRVEAQSGKCMMDALAKAQVVVGDSMNGEYLVIIHAGLNDVLKGKNHSLQRQLEGGGYGPAAGYSVMEVNQDVYGPGSRPLHKMAFITVALRAGGALRPTVQTRTISKGHKYSRRVESVGEEIDVSTRAKLIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6U4</accession>
    <name>A0A9D4Q6U4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_002547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6U4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038739"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="12">
        <location>
            <begin position="50"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="11">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7967797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="409" mass="45258" checksum="7BD359A9B41E0D4B" modified="2023-05-03" version="1">MHAVSSSGDLITVSGNAPYVRAWDVHTGVLQWEKTLPHSSAPLVRYDVNSHASELTAVEVHPGSHVVATIYNLQNGEMKTSPVVSAPWITDRTDCRLVEHKYLACLDAKASTIRVMALGESAAFRDVPLSSLGIQLDDPTAVPVLQPIQGPTRAHEDSYLALRMPNRGFALLRITKTGVRLAKMFPNATHLVSMGDGWQITRKPQENAASGTGDEPAYIGVVEQLENGISKVFIYELGGNWQQKEDSEGRVMGDRSVLYKYLNPNLVAVVTEGTDNIHKVTSVTVHLIDVITGAFIYSGSHKRARGPVHVVHSENWIVYCYHNEKSRRAEISVIELYEGAVQSNTSAFSSFNSPPGAIVEHQSYVFPSSVDAMVLFWNYQRHFSIQEDLSHRQPNTGKKDLSRTRLNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q796</accession>
    <name>A0A9D4Q796_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q796"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041221"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14566" checksum="DBF7EF3894236692" modified="2023-05-03" version="1">MGPTSELFRRPGSEEEDPLQLPRSVINRSEITLSSEELALDEHQLQQDFSEDIDADVDMCENAATDEDIVAAVRGDEDGAALESMPVEDSDDIPDMSCKDSLEYLAKLKGFCAAIKLTDEELQELQASSGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8R4</accession>
    <name>A0A9D4Q8R4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8R4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041325"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7971752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="28936" checksum="38CA9A73957F3A2B" modified="2023-05-03" version="1">MVKKSRPRESTWGKFKISAIGLSATYDHVRKNLDKSQYTSDLSSGPDRGRKRHRRAPLVYTESEESESEHSQHASKKLHAPVVPEDFPQDFEQNTTRLLNIIRYMLQQQGEVLNTIVKTLSSLSVAPCAAPVIDQPFSSLEELLAFDEKLDNEASNALVNDFVQLGGSDGNWATKRILAYCMTDEVAAQFSWMGRKGKRSFSALKIAKVVKEDNLSPDVPPGYTLSGNPSHYRAYDLLVKKAAGLVRQEQAQKASLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9K2</accession>
    <name>A0A9D4Q9K2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9K2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66425" checksum="FE5FDB977BEE1D67" modified="2023-05-03" version="1">MPSIKCDSSGRWVYKDETSFEDIEAAEEVEFECSLCRKIDELETQLTACQQRACSELQAKIETLEATVRELAGQMLQLHKQQPPMVCENTEGHHDENKSTPQPPSETPASELNGHSQTQLRDVQANSMVSEQASAGDSLDQQGSPRGPKRTDIQDQPSLPSLTSGEIMKATETHSEESANQREPTKSGARSKRAAGKQGPKVANMKTRTDSQPQQQTTDHPSTRVDPKVNKKWVRPDPEAEREVIIVGDGNVGRIVPNVQTNVYPPKAVGFLFGKKATSEKAMHYVDTYERKARNVLRQYIVHVGLTDALRQDPCRIAQTLKTSWHNRMAKLVVCSIPEITSRGDETRAAIHLANAQLRNWCKRSRHKFLDINEGWRPDMMDKDGIHYNNTGVCSVAMKISTVAQAFLEQRRQATQAADTATPQPEKSTEVERQPDYTQGWRRTPDGNYRPTAQDTSSCDRPTSSSTAAARTANMGTDSNFPMDHPRRPKYYVSHCRGAGAAPPRDGHESAPMRRRRHPRRHKHTTPRVNVGFINLHGARRMSRVTRSVLKTKQSTMSPDLRDVWEGGDVRCRVRSESKRVGIHSRLPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9T0</accession>
    <name>A0A9D4Q9T0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_016832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9T0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054428"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="491" mass="54116" checksum="EB1589D3A1102FC5" modified="2023-05-03" version="1">MSLRWRSLASRSRLGSGPGGDGPWEPDECVKLLANPDLTRLTVVKRELGRASSSWMTRFLELDGLDALFCALDAFSGHHEASFQDAVLQLHCVECLRALMNARTGLDHIVKQPRYTRKLAEALASPNRVVRKQVLELLSAVCVYAPGGQVLALDALDHLRASTGREHRFSVLVDELSHPEVLPYAATVLAFINCVLISTDDFRERLRLRNQLLGLGFLELVEPLRRSGDDELFIQCHVFETTREADDEHALSLGLTASGNHYEAFAAVMNKAGYRPTQQSPGRSPRHRSHLAWELLERLSQQLSSGPVLPLYNAMGPKLTPTPPELAAMERLDNGCSRHRGGSEGESEGLKKSSARGGTDAQVSALSRSTSYRSKSTQARRSSQPSPVVRRNQEVVGVERCPNSTNLTKRSIEASPQHSPSQRSSPRSTQLTRSSVLRSSTDGQPPVVAAACKTRTSTTPDAYLRLRYPVSLKNSRELKLQPSMEARRSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBE7</accession>
    <name>A0A9D4QBE7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028725"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="474" mass="50651" checksum="F78787C0A57DD60E" modified="2023-05-03" version="1">MAPPRKSNVEVGSQVVVKDHPLPARVIHIQGNQCQIQFVDDSIAVVHLSSVTKTETSVTVRSRTTRSRSSSKSPEKKRVTSRSRSRSASRAAATSSRTPRSPQKKAAAPKSPSPTKKAKSPARKSPAPKSPGRPAKTTRPKSPGRPRSPAPKSPARKSPAAKSPARKTPAKTRAPSKSPAGTATQRKKSVSPARERGGDSPRAGPSRIPVSSSSSSSSLETASQPPARSRASLSTPLGTSASQPVVNLGANSITRRVVSSPATGTAPHVYSVPGVRSSPRIATMHSTSLEEDEEVVPSTSKKSVVQFVEPKGRFQLRMPQVRLPFRLGMSLNALLWFFLMPSLALVLHLLCQKAHDDELPSADVAFDNLRAGGVLIPAEITLEGFADADKDLELCAELTDDEIIHQVTEDSDDSDTENEEPAPTQPTSSELTRALMILSLVYSGNMTLTEIEADIIAGKRTVQKKISDFFAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCP7</accession>
    <name>A0A9D4QCP7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="2">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_000635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046953"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7975374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13001" checksum="79D3ED98EABD4D8A" modified="2023-05-03" version="1">MGVRSYNEELGYLEKMTPVSWRIKKGFVPNMKVEGIFYVNNLLEKLMFEELRNSCRPGNVGGFLPGVKQIGNVAALPGIVGHSIGLPDIHSGYGFAIGNMAAFDMDDPKAIVSPGTSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCV1</accession>
    <name>A0A9D4QCV1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCV1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047021"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038625656" evidence="5">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7975495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="142" mass="15420" checksum="039142CAFD6857CC" modified="2023-05-03" version="1">MPAVRRRWLPICLVFLSATVLGEIEAGGAEGTCEPNETSEDIGDRSTCTFTTTFDRDATRVPPELPVVRCRCPDGRCGGDGDFRCHEVTHNVTVAYRVPGSSTLRNKVIRLTTACVCAIGKSQEASDGLVRPANLPRKELPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QE08</accession>
    <name>A0A9D4QE08_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QE08"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034203"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="22761" checksum="07795C49C8DAAAB7" modified="2023-05-03" version="1">MPRSVHSPATDQTISQFPDSAPFNRRHDNATSVIEPPYQLFAHRPAVRGTQLILTSPTSAKKSCTDHVRTSGLGSNASMANAYTPRLFLVQMVNMAYLLACFAGPPCTAGESVVLPSLEMPRSVHSPATDQTISQFPDSAPFNRRHDNATSVIEPPYQLFAHRPAVRGTQLILTSPTSAKKSCIDHVRTSGLGSNASMANAYTPRLFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEU0</accession>
    <name>A0A9D4QEU0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEU0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="15094" checksum="8BC7BD1EBD667EEB" modified="2023-05-03" version="1">MDTQRAMADLPELQRRLLERSRLLGFEPYADAPMRVRDRPSSEQDSGSGDDGEEACAVEAPVSRPRGKTCASGSLDHDLTPPELFRWCVEQEVLRRYGVTLEASVFCVQTETPKDIEAGLVVFWQKVVGTHETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFF8</accession>
    <name>A0A9D4QFF8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_019992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFF8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF28">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7976815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="394" mass="43652" checksum="487D879041AC15C3" modified="2023-05-03" version="1">MTGWLVWQKTDFCPSRWEELVYNAVVGAIYTFCFFNVRDGHSRSRVVVFYILIGLQNVAFLIVYCVTRGEGDDLHVITSAAVVLGSFGIGMYCMALYYRFFHPSGPIYLCSDKTAHEESVQMQEQGNVSGDVSTPPIKPFSAAVSASHSFRTLKYANCAHHMASTPRQMDPERASSLSGDSTISPCSEDTPNSARIFDKATAEEMETGEMEDSNMYRINVNLSGDAASQLQSRRVRFDLKDCSLDESHRWHSEDCSFADVKSDSDDVTALSITKDRLASHHHVVNYNFRPFVGEGARAHPFKRHCSCLVLFECPPDLGFESLLLSTDSKGSEKKALLNVMSTPNVRLQRFNDESGSDSAASWSMHNFLAADRCTEDLSESVASDLASGSTTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFG2</accession>
    <name>A0A9D4QFG2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFG2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7981863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18072" checksum="1B2C318FBC81B068" modified="2023-05-03" version="1">MEGHDPRTPVTSFVRVSDVAGLIIARHVRSLHPDARVASGNPPHPPRLLPRTGLNRRARAFLVRLRIKCSRTAERLFRLSGSGNPMCVLCPADETIGHILLQCPGYDDHRRRLFGAYSRLGLPHLCLDELLFPRAQHSKLQQARYALMDFFGDADLFTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGI9</accession>
    <name>A0A9D4QGI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041321"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7981862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="183" mass="20752" checksum="13470EFEBF241D60" modified="2023-05-03" version="1">MDSTTFKLMFRFQKHDFNDLCSALLVPREITTAQNVRLCGREALCVLLRRLAYPNRWCDLEGIFGRHSSVMSSATSRLMDHILSTFGHLLTDVNNHEWISPASLKEFAGLDGHYPGSWHDARIFRETVVYTKLERLTANEDFVVYGDPAYPLRPLLMKPYGGSHLSPAQQAFNCGMSAVREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHQ8</accession>
    <name>A0A9D4QHQ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHQ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028671"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="16101" checksum="DEFD189E25CCB3CA" modified="2023-05-03" version="1">MALPRITGRQMQRSNVPSATPEEYYRRNVYLPLLADFENQLRDRFDAHKKALEMCNRDFFPNIHSLLSILATLPVSTSTPERTFSTLRRLKSYLRNHMNNDRLTGLALLSIHRELQVTPEQVLTEFCKLPRRKNFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHT6</accession>
    <name>A0A9D4QHT6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_005099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHT6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035428"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="874" mass="94412" checksum="06E0F660CA81C424" modified="2023-05-03" version="1">MTASSESNESETGSDTGFETGSDPPSVGNRDTPRTSPSPEVVKEDVPLTGQVLDLRHRNLESLVVRGAFSETLERLNVADCGLRKAPESIWDATSLVVFNVASNFLQEIPPEVSRLHRLRELHVDFNELHDLPGELSALVQLRMLSASGNRLTALPEALARLTALESLRLSANAIAQLATPPVLQALQALRRLDLRSNGIQGVADFTALQVGTTPSAREYRRLAASLLFDFSFHSVTSSKNQLVQVPYWVPQARSAQHLDLGHNCLTSVPASLFSPTLSQLDTVRLNHNSIASFPESITAQCHIRHLDLQHNCLTALPPNLLRHAYRLQWLNASYNKLSSLARPDQTSFPLRWLLLTRTGLTDEQVWPLVLACPGLKVLQLAYNQLHTVPGRISELDSLRDLVLTGNALQRLPDSLASLPGLEALLLNCNRLDTLPNFEHSRSLKVLDVSCNLLSKVTLSSLVSPSLQQLDISCNQALFVDTQEFHVLCSRRNVSVVDTKFSGRLAPPFKSNGPAQSCLESPFWTTGFSESLKGPARLYINQCTQPSGHTEVLAAILESPQRQLLSTAKAAVAQLVRQERRSAESSAVFLQSIILSTYRALGSKACCHQLNILLCHLAPADVSADDTDGAAYLMTVAQCGGATCLLAHADKQATILFEESGQSTRCVADDWDAAEGFQTHASSSWPSTARGPPPCELPSPSIRHVTLRPDDRLVVLSTAALGDALEPEAALAEALDAPNPMAAAKRLNQAVASLVSDGGTCVIAIGLQPAAAAVAAGGPGKSVHFRITTDIDDEQADEAEAYKAWEYMLAQNHKMLFNRELETLHRTLAKGKAARHATVADGAAAAAFGTARLGSKKKRYCYGQAGEPLPSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJ93</accession>
    <name>A0A9D4QJ93_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJ93"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054761"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="1">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="28289" checksum="78A12EA12C1DD874" modified="2023-05-03" version="1">MLKAATTPADQASLLPSSPQGLAQVSKVAVRCTKKAMEVRVEFDAPFTGVVYSKGHFEQPECRHVQADATPGNSFEFVIRADRCGSSKVERKTKDGESYIENTIVVQNEPRIQEWSDSARRLRCSWDTNIDRTVSSSISVNQLEVQQARYAGSSAADSYMDVQLGRGPFSPPVTGLVRIGDTLTLVVYTLGADLDVLVKDCLAHDGDPRRAVQLTDARGCVAKPKLLGPWQKTRNTGATGASTIAFAYLKAFKFPDKTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QLB9</accession>
    <name>A0A9D4QLB9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QLB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034669"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000032">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7982635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="304" mass="34622" checksum="3079586D89CBACBC" modified="2023-05-03" version="1">MVELDVQLSKDKVPVIYHDYHICICMKKRKSPLQEEEKLQLAVKDLTVAQLQRLKLSPSVHDSHHYDFREDDLEDNQPFPTLQHVLEAVDPSVGFNVEIKCPMQFRDGTWEMDLNFDMNQYVDIILRTLLDFSGKRYIILSCFHPDICTMIRLKQNKYPLLFLTQGQTEKYPPYLDTRTSTIQMGTYFALCTHILGVNVHTEELLREPSLITFVKEHKLILFCWGDDNNHIDTIASLKRKGVDGVIYDKLDLFITRGPENESVFHVHPGSTASLLEAASSSCSRENLPENGVSSAASSCSVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN04</accession>
    <name>A0A9D4SN04_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_001977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN04"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7934905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="405" mass="44767" checksum="51C57C9C1EF12291" modified="2023-05-03" version="1">MSSRGSSKTSCNESRSAYRHVYFQRQPFYDVLATLLPATPLKSYEHSRCHKSLQFEFLPRHVDDISTSSRNAVTGSEFGVQVHLRLCLEDRRGAQEDSYPADLKVEVNDAACALPASISVQAPGGATVRVCLPVNIVSSCLLYPHVVNKVSLSWQRERDREYVVGVFLVRKQSAATILRELQVRKAPSMDLTRELIKKKVQERARGGGEVTVTGFHVSLMCPLSKKRMSLPCRPLGCKHIQCFDALTYLQVNETRPTWTCPVCGRRPSFSSLFIDQFFMHILERVHADCDNVVFHKDASWTPSAPPKDVVLAGQASSSYASSSKVSSSSSSNEQDGRPNKRRKTKFVDLTVDVIDFTEDSGDEAKDHEAGACLQQEPAREAAAPTCPAACRAGGSSRIEQRVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN19</accession>
    <name>A0A9D4SN19_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">A-kinase anchor protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN19"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054478"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029304">
        <property type="entry name" value="AKAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042779">
        <property type="entry name" value="MISP/MISP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18839:SF0">
        <property type="entry name" value="MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18839">
        <property type="entry name" value="MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15304">
        <property type="entry name" value="AKAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 2 C-terminal" evidence="3">
        <location>
            <begin position="654"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7936018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="850" mass="91330" checksum="F801ACDFC6C1B283" modified="2023-05-03" version="1">MDSGPSVARLDLRQKCAANMADQDDQQQLIGFDDSPVVLPAESKKGAAPSEAERILNSLNAEKSQLAATTNGHNGDATTTNGHDEPEKTVNGHAPKANHNEAGEPVYTEVPEDNIYEEVIPVQENKPEASPTVQTTTTESTGVLYDDSSLSSEVSAELSPPPSNVGDCGSNGTTLSDPECDAAMAEASAPESHADIPFVVVQESTPVDSEQSNDEQDSASEAITEVATDVEPVVEKNNTPTSDERPSDEHCFSAQPAVLAAGGESRLDDIESEFTRVDDVLFVEPEDAARCSVVSVTETEQEAAVEECSSNIEAMHTEDTVPVIEETTPSTQEPAFPVEHELEHDPVECQDFPKEAVMAPPACEQGQIAEPPPLTTVRHESRHLKQSVEDSIVAREIRAQKEREEMIAQERKLAQEAARLSSTTPEKPSCDRTPETPKPARLTAPQLSMASATSPPSLVSSPAPFPAPIEKRFTCPSDSKIADEIRELQEREEELRELRERLHIQSNDHKCSEVPNSSNDDGIAANGVVSPVASLTSSSGGLSRTVSVESLPPNGSTLFGPRRKDKITVRPLSDGTEDAVPSPTFALGESPIEREIRLARDREEALRKEKGLLGQLQAEGFIKKGEAASPTPVKGAKVPATLVLRGGSTQKILATSRIQQEIEEQTQREMALRESGHIQTISQERTDSKVTRIGNEAVASPSPPLASATRRVAPFESSLPNVEIFEKTPARVSSPTTVTCGVSSVVAKTANGHVHANGHVSGAKGSPVANVRGVSMQKFLASRGKELAFTSPPSPQNGDKLEYRELKPPQLQKGAADAVRKGLITAETKIQEEMRAMKEREEELRFVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPL1</accession>
    <name>A0A9D4SPL1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_011345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057129"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="231"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7939338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="956" mass="106475" checksum="16D83B97C2146442" modified="2023-05-03" version="1">MMVGAINDVDIIIPCGDLPKLIKAVSDHTDTVQVSRFEVSPRYTPVFAQNYSGSDMEPQERERSSASKGSKKSKRSRSLKKRSNTDSPYAEVAGIAKTPDQNRHESEHSVASTVQEGSDFKKGRRSKKPRSLPSDALEATKREAEQGGAMVPARPTEPERINRVQQQPQDGKGRMQQSRRSSVGHDDRKTRFMTASRRRVFDGAIFAVFVLNVMAVVWLLIRAWDSEDVYVTVPGLGAIRGIRATVEHQPVYMFRGIQYARSPEGALRFAAASAVSQRNSTDIDARMPKPGCVQKPYMAHGQVIRSNEGTTEDCLHLNVWTPCTERTVPGCRKTVLVFFHAIEFQNGDNNYYDGRWLAGLGHLVVVAPNFRLGAFGFLNIACLLGDAPCAATDVALGDQWMAVQWVLDHISSFGGNASDVVLMGSASGAWSLGAHLLKDGTHGPRFWNRERFAKVILMGESPFRRYFDDKSHELPSLLNCSRGGTVEMLECLRIVPSRDIVRVTSEVVHYFGPSASAHPSVQDAARVTGRRFLLGTVSNEGTHLLDYLRRTSPPNAGMDNVVPVFLKRIYHINNGGEIIDAFRKANAPDENVTTSGISWASELLGDMFYTCPLLRLGRELSMRERNLVFGYVFDHRPSFALFNDTTGSARFMDLDFVFGRPLDGSRAANEQEQELSRRMIDMWATFAKTGNLPFVNGQPWPRYTEDGKDVQVRIGLTHIEWNVAAHIITGRSNHSDQASVALQAYYRSCVTEIWQPGLRLKGATEAILEIANTKKRMSQAHLLHFTLEVQFRYNLNSLFVVGNQSGMAYLARNLLLYDDYAHLCDRDCYSTVLAALNVHVGANCTVEEMFEWEQLFADAFSAPQNASWGELRAIFGGIEAGAFKAIFLEFQIDFDAVEFVLVDSKAELFADIQLVWNLANQPLSLCHALALLVMNAMQLSLHNDATLNQPTAQSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ50</accession>
    <name>A0A9D4SQ50_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ50"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="488" mass="54054" checksum="92102B64E00DAF5A" modified="2023-05-03" version="1">MKPKQGLIVRDFTNHQVARAVAAACGNNEVCRDEDILIRLRNGSNIIIASMPQKEAANRLRRITKLTLVIKSYEVNTYVATPDGVVRGVVHGIDAGTPSEELMAHLRVRTQGVKILQARMLGKSKTAVITFEGKVYRVQISPEKGKTPAQSQPGKNGVRNTRRSRKDSSDGKNKRRWFSSKRDNSASRSRSRSRWTSTTRQQQDESNPNRGKKKNKKTRNVGWADIAADSNAPANTHTIQAINKCNECASIRRQLEVMRAKYNELTRKVDNLMKAIKERDTNVDGHGGMRAAAAKENSGKDVHVTQATALWVDQTAFMKNAQTTNPPLTGYAAYLSQTEGKATTLVFKAITAIQHPALDTDIEHVLTEVIPHERAEQYAQELSKQNWNEFCDSLKGTLGTAKTLALLRNMIDPTKSKTETKTLHRIAHNFQGNDAELLGKISERYNGSVNIAAGTDPYRESDCDDAPPLTVKNPGNGSSRRIATDCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR55</accession>
    <name>A0A9D4SR55_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044305"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37551" checksum="FFF096483F41B068" modified="2023-05-03" version="1">MAWDRVTPTTIANCFAKCGFFRSSEEVPSEQEEPIEGWELLDAGCTAEDFCTADDNLATCGARTVEDIVEEATCEVADSSDDGDNIDEGDGEGLPPAAETLHALDVLRRAMAADEISDDTPAGGDAGEGEARPAGASFFYACRRTEWLWLLCSSPRSCFVVMGLLVRRLLANIDRKHEGDLRISLLDAIHFIAMAWDRVTPTTIANCFAKCGFFRSSEEVPSEQEKPIEGWELLDAGCTAEDFCTADDNLATCGARTVEDIVEEATCEVADSSDDGDNIDEGDGEGPPPAAETLHALDVLRRAMAAEEISDDTCTRFYGFQRSLLSDFAKKKKQKDIRDFFCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SR59</accession>
    <name>A0A9D4SR59_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SR59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046802"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="84" mass="8987" checksum="4E02653DCC5EE7D7" modified="2023-05-03" version="1">MYDVGADEQEASTRSKAGSEKVADRTKLALDLNKEELPVQKGATPDILSPQSDVTDEDTTCSASISDQEVFPSDADKLATLEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRI3</accession>
    <name>A0A9D4SRI3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRI3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056039"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="218" mass="23829" checksum="7078A3E8B1CC665B" modified="2023-05-03" version="1">MASCRSCSAAPALDQYLSSSAILSEGTLSEDSQNAEHESKRSDATLLTASDSGGTAMVSGSLDIANFVEKQVDNFSKSVAKALESISTWTEMHSSAKAKTLLAAIKDGEFLVTIICLADMLAHTLPLSRLFQRQCIDVRTAKNALVDTMAVLDKRRVDSAETFSQLYKDAVVLADELETEIRSPRITKRQTYRCNAPMPDVESYYRTDLRSITGQCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS10</accession>
    <name>A0A9D4SS10_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_009248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS10"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048653"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7943582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="20900" checksum="C0E5AD2DF4A44536" modified="2023-05-03" version="1">MVAIERNAFLESELDEKEAMSFMVQRLKDEARDLKQELMIQQSSVHKEQSSFGPDSPLVQRRDSTGGTTPLIPARAHHSRILGMSDSNRLATEKAASNGTAQQLPLGMGSSGQTPLTPSARVSALNIVGDLLRKVGQSPSSGGLDLGSSSPRHKDRKPATDSSSPRACEQHSNSQGTYSSTSCIATSCPSYSLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SS30</accession>
    <name>A0A9D4SS30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_005690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SS30"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038494278" evidence="3">
        <location>
            <begin position="27"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7943133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="636" mass="69584" checksum="FE7A84098DB2FFE6" modified="2023-05-03" version="1">MGCIFGVVAFLAALISVLVLNSPSVAEDEVRTTAAVAPQGSNDGGTRMEENTIIIPRETVRPHVPTTETETTKSETTKTHSTTVRPHTTTRAPDTSMSEHPVTADTFTHEYPVTTGSPTASPEFPHGTRGPLLCTVSVHFKESSSLPEDGLCGIIFYDSLYVKNNRGHWDDKGLDHFLDLGGNMYRTKIGASFSLANGQLFDDADTGRLYADAYILYQGGVSSFGMLDIHGDNVTHRNFIICLRILQIQCREQRKKYGQPAGALPPFNPQGRVSPWAQSQQDQLVCMVGCILGVVAFLAALISVVILVAPSVAEEDGRTTAAVVPTGSKDSGTRVEENIIIVPRESATTKPERKTETQSTAVGPRTTPRAPDTSMSEHPGTAETFTHEYPGTTDTPSASPDFPHGTRGPLLCTVSVHFKESSSLPADGLCGIIFYDSFYVKNDPAHWDDKGLDHFFDLGRNMYRTEIGASFSLANGQLFDDANTGRLYHEAYKLYEGGVSSFGMLDVHGDHVTFGKSLPKCLSILEVCVALIKERSSLQFSLAAYDIDFDEEDAPCPNLFIGRGSFRRVQALGFMSSYRPELHEDLNYSQQQCMAKVYSGVENPCCPHSAQTKRRPSTRIPVDPTWHRRSYAARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSJ8</accession>
    <name>A0A9D4SSJ8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSJ8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040404"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051448"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF1">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="100353" checksum="103C10A2F980B773" modified="2023-05-03" version="1">MESLSEESKQTRLDAIAGRVDSFFDSHRVEHFPLRCTANRLTATHNDKVCPINDYLPICNGLLFDVGMELREQGGSLSLVCFHAYEADVMPPPDADLCRANTFLRWLLRTHVCIAGLELQYKWLTAHSQVVLDELPENSRLKKLRLAFSYGDNAKTHFAKLLPRLRCLEELDCFMSPSEDVLVDAVSALVRSTTSLTSLVFRACFDHGQPPKTFIDALAENSTLKSVEMWANWNTAEPPGCLAEYVMSNRLLTTLTLFSEHTDRQELSLDEALVRNSTLSTLRIGTLCGGETTVRFLTRILAECPSIRKLSLGGLRDTYVNIPGTTMTRCTEAMARNETLEELELSYSLWHQQNWIAFLAFLPKNKHLKKLEVSSHSRTDYATILHVLQALANTDSSGRISFGSYTHESAEVGLMRFRAFSGINFFGTASMKVYALQLLPAFDHFTSVSLGFYYSNKRVFSYLAKYIRATTTLKQLWLFATRRGEAASSSYWTLLFESISANTSITYLIFDGGDNFAYSGRLASTVGLSKYITRVTYIQNGSGWNPASFVLPLSDSIGGNYNLLEVRLTSAKLAAEARRSLFAIRETTRRNSGLLERAASAFNQTTPLDWYTATALEKVSRHPVLVREIAEKGGIAADEVATMIRSHLKSVEGLNDFMRLTGVIKERVTCAAPVDGFSMQLQGLNNDCWRLVRRYLNFDDVIAKPEEPDVMPPPDADLDRSNTFLRWLLRTHVCITRLKLQYKWVTAHSQVFLEELPENCRLKKLRVQFPSGDTVQTHFATLLPRHTANALEKVSRRPALVRELAEKNGIPVDEVASMIRRRLSSVEDLHDFMRLTGVVKECVTCVPPVCGCGVQLQDLNNDCWRLLRRYLSFDDVKRFTVVETDDAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSX5</accession>
    <name>A0A9D4SSX5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSX5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050770"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15209" checksum="1508D7B1967EE61A" modified="2023-05-03" version="1">MPPEACEAPDNKGVPEWLPVLNEDASGLNDFLRADVEMSECLSDEAIVAHIHAAASGESDDSDDTVEQPTQVLSSQEAQQVTQSLRDFVFAKDLPLSYMEHLDALEKDVRHKLTDYGFSANKYILVALPYLHANKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU59</accession>
    <name>A0A9D4SU59_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031217"/>
    <dbReference type="OMA" id="FYWITDK"/>
    <dbReference type="OrthoDB" id="6505771at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="165" mass="17641" checksum="D600C721A7C4B25E" modified="2023-05-03" version="1">MGNTLIVDSILTPFSWYSLLPIIGFAAFLFMVAAYQRTEFYWITDKASDVMHDLASRFRKKPRRVRESHVPWFITGNSSPATYGIGMTTFPNNPGSAGYDPEAFVAASSSGGSTVLLNSAGTGQMDTPSQVGPMSAHGAGSHVHGVPAVPVLIKVTDLSDWSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVI8</accession>
    <name>A0A9D4SVI8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVI8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035899"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28361" checksum="50EC1932C43EFCEE" modified="2023-05-03" version="1">MIQTAVGKLLRRSHGCTPRLALRPYNAMSTSVQTQALPPEQLERQHHMAIRRFMRLPHQPPVASTLAGAQIWPLRCIMWTASAGPPEAVPSFRVLGANHPHGWDRSAHSLLNLFPRLSPLDVHFEPDNLSKRRTPACELHQSAVAKLHDRTRRHLPVFAHGALSPSVLVQVVGWNPFAVACVTPIAGTTTQCSFPFHASSTTAELAGLHLAADYLVATTPQLSVAILCDSRPALQARLVPSHVEIAGEEEAAALTPPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW62</accession>
    <name>A0A9D4SW62_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW62"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9863" checksum="8F56984C74481882" modified="2023-05-03" version="1">MSSQAIPGTTASSTTKRKVLSLKVKRAILDEVRQKIKKTDVARKYGIAQSTLAIIIKNASNIDAVLDDVGSGERKRIRAATYGDVKAALYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXT8</accession>
    <name>A0A9D4SXT8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_020744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXT8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035592"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35810" checksum="09C5D7DBFE9F6FC0" modified="2023-05-03" version="1">MQGRKLELRDSPALPEVRHHRHSQNGYVPTHPHTGHTTDYTAWHRRYPSCGGSQQSPILVLFAQSEYKYFDPIQFLNYDSYLQIDIEMVGTTLFFYPFGVDLGVFGGPLQVQYSFFMGTIHIGKDRHSGSEHFIENQGYAAEVQLIHTTEMLSDNDCLKEANGLLVLVILFEEKNDDNEDLAPLLDAMQELQDNAHNLHTSTKFLMSSLIPDDTLEYYIYPGSLSFPPCTERTINVVFQRTLEELRKLRWRLGGDASCTGPLAGNVRPITDGRGGVKSTRTIFRSFFSFTPSTGASTHAVRGAAVALFAVVASSASLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXV5</accession>
    <name>A0A9D4SXV5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXV5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="90" mass="9946" checksum="58E87AD304C62EF5" modified="2023-05-03" version="1">MSQRPPGSLDFLDTTQFTGTTVTAAAGVRSQSNYDAAERAFDCTILLPGLLFKTHHMRAVARPVFWSHKGNGFIQKFFDSTKSERPVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY26</accession>
    <name>A0A9D4SY26_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY26"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9807" checksum="D646CF93FC4E09BE" modified="2023-05-03" version="1">MERLRSTRAARRRHSTKIINEVCDLLASNDFDLAGLRSILQRLEKSTDELVKANEALHAEMTDDKMLADFDSVLEYEDRAAGSVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T021</accession>
    <name>A0A9D4T021_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T021"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="10104" checksum="9758C9214967AC58" modified="2023-05-03" version="1">MQYRAYFCQPFREQAEEAPHEERKFLVFESNLRELLAFCRLCHKRCRNEFKLFQTRQDQLLKDLPEDGVEIAGDGRCDSPGYSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0Q9</accession>
    <name>A0A9D4T0Q9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0Q9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="66" mass="7260" checksum="CF83333FC3D01AB1" modified="2023-05-03" version="1">MQPKKIMNASCSGKLENGSCLSFGCACRNYKLVKKSSPNQLIVTQALKAFEARTSSFRRSMKPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2D7</accession>
    <name>A0A9D4T2D7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2D7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="118" mass="13888" checksum="5264AF275DFCE67D" modified="2023-05-03" version="1">MKDAVQTDVTWQRYLQLKRDMQALVQLKSEGRNAAQKFWNYVRTLNRREQSAQFIVDSTDNPALDMKETLTKHLKTMYGPLGCTRDLQFDDRNSQGVEERIVQGSPEEEAPKWELRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2K9</accession>
    <name>A0A9D4T2K9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2K9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049795"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="61418" checksum="1A04D9503EA72106" modified="2023-05-03" version="1">MSTRPTPETRLKFEGYFELGMNPSEAKRHNERLLLAGGDGSPTGPANPKLSCLYTWYREWRIDKYGSPENPLSKLTEKATAYATSGADIKLTGTDDSWAVLLVTPIMHRAQQIKSSGDLIFVDTVSSCDATKSMVTLFLTATKAGAVPIAAFIHKQQDTEGYQKAFDLLRTDYPLCFGNRQVLNAKSHEELARAKEELCRSNHKVYMEQAGAFFAREREWSLPSRVSLTAQNWDVAAYSEVSVRILRDFLLSKMQLYNAVALLDFIASECEAYLKARILQHSRPVSYADYQWGGSCTTSLERLLSRTPGASLGSSVILREGENAFSFRNAHNRRECAIQYDLGLCSCWPGSQGAFCKHQAFIVHEFKLPFPCTPELTTAECEELVTLAIGRRSLSPTASPNHQTCNLDSASNGGEEDIWALLDHDYIKEASGDAGDSNTELPRLDILESACVEISQDEALVTEEQSYQALVSSLRQVHELAKDVPGYVGLVDRIVTEVKDLTTSHAAYGFLLRLDASATAERRRVLAPPIKRPRKMIRTPVRSKTSTPSIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3C3</accession>
    <name>A0A9D4T3C3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3C3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028935"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="33608" checksum="536657D62511D6DB" modified="2023-05-03" version="1">MEVSWGGDTVASCGVQIPASTKKLWSLEETGPKPEDSKGLFLGDQWRDPTWSTGGHASTSEHAVSQPIMVQRRSGSYPGSEGASMLSPRSSETSGLGVKMVEYVLGSSPTIKDLDSRMVGRMHVGPPTNDPEKVKKGKEGKLKDADGRTAVMQANGIMHNGIDDDKVYNPVGYRGGGGSRQASPSEDKGDKLSKAPLEALVMGPGGSGPPLEAHFDHHTMDLGSFDYPPHGLLPTSMESPGMLDYASQYSMGQGQQQGGALGVPPPTAPTPSPFAPPSTPYLLNQDPYGAPPHPLGIVTAFSPLEFSEDSQRRLTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3Z4</accession>
    <name>A0A9D4T3Z4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3Z4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12849" checksum="CE4A4BFA408755CD" modified="2023-05-03" version="1">MRIWRDVLTTQGSVLFGTIHGAIGLMGDFRFRAIDGGSFLDSFLCTWRSFSTERKTEQAVGFIDGDLIESFLDLSRDKMQEVVQGIQMDDGSGMKRDASVDDLIKIIEELSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T431</accession>
    <name>A0A9D4T431_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T431"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047193"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="290" mass="33157" checksum="6F9B5FD8DE429069" modified="2023-05-03" version="1">MLTRADSLSEKDSEEKEPATALLWTYYYAAQHYDYLGCTAKALDLINAAIEHTPTLIELFVAKARIYKHAGDIHEALRFLDEAQALDTADRYINSKCAKYMLRGNLIKEAEDMCAKFTREGVSAVENLNEMQCMWFQTECAMAYQRLGKWGEALKKCHEVDRHFSEIMEDQFDFHTYCMRKMTLRAYVSLLRLEDVLRAHPFYFKAARVAIQVYLQLHDHPVAETEAAEEINTGVSLLPSLTLPATDYACAIKGKRWSGNAYASVSFVDDPIVWKAGKMIVRFMQAAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5Q7</accession>
    <name>A0A9D4T5Q7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5Q7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046669"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="41978" checksum="5959F01EF8694AFD" modified="2023-05-03" version="1">MHLDPDVIALQETEAEDFKVSGYLTHVSDGKKRTAILTKKTINAQQHCIHHRIEHTLVEIVPEKKHQQSLFVLNVYSPPKDHLKDLDKLMREVKKLSKGNGLIVVGDFNAPHVAWGYTASKKKGEDMHNVAKHHHLTLLNDPQTPMRIGNSVSRNTSPDLTFVKGLKHYEWSCMDENLGSDHFIAETITPHHKSATKIGKAKITDWQAFRKDESAVDATIDDIEMWTRRVVERAEKHTRVIQLSRDTPVVDPHLLHLWEARRGLARRWQRHKWNRKLKVRISKLVEEAQEYSEQLERKNWHNTCNKLQGTLSTKRTWAILKTLLAKKETKSAAKQKVHRLIHNHPGEAQDIIKEVKEKFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5U9</accession>
    <name>A0A9D4T5U9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5U9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033125"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12510">
        <property type="entry name" value="RRM1_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="303" mass="33291" checksum="54F34C4BF569C07E" modified="2023-05-03" version="1">MVAAICRCRKPSIMSIIIRLQNLPWVANSLDIRRYFQGLNIPEGGVHIVGGEKGDAFIAFSSDEDARQAMERDGGKLKEVRVKLLLSSRAEMQRVIDQARAQHAAPPPVKKEEQRRRPSPDDRSRRPPRDRSPRRRSSRRDRSHSRTPPHRRDKDRSRTSRPDDRGRSFDESSKVSNGQASERKGSDEKPPHSDQSKMAPPVFQATQQQSDVGSAPVNMACPPAPLPNFTNFNLPPVGLLNNLSGLAANLMSGLMGTAGGGMMGTMAGNMGEGVPVNVARIIPVVSSLQSVVACRAAWLPEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T628</accession>
    <name>A0A9D4T628_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nesprin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056303"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="237"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="766"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1228"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7972825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1336" mass="150617" checksum="9520009B43B4655D" modified="2023-05-03" version="1">MSHQAVVSKLQTKSQELKETSMAGQVDGLVSDYEALCTRTKANIAQCEKRVSEHEAYQHSLERFLDWVSTLKATVDGPEEQGDMEAVKAKMAAYALVLESEPEACAKLEHLRDALESRVLPGTCPSGHEALQEQYAAARAQWEALLDACEEGHSHAKETLDRWDEATKTLDELEQWLASQRARCQDIPLQATAEAKRQQLDTLKKVEQDVVAKESDFSVLSKNAQAAPTDTMLTPQLDKLRSKYHLLRNTIKEAVAKWEKLAKQHEAFDKLLAELEEWLKQPEKELDEIVDAKADLASTQDQKNKLENLSDRLAQRSSSMDELVESGERLYSHTAPDGRETIRQQLRHVKGRWQTLVERSTEALAELDQRLQQLSGLSQSQDQLRQWIEDVKTALDSCSQPRATLQEKKAQLQTHKVVHQDILSHQPAIDSMCERAQNLSATAAGKDTLGDHVQSTKAAFQELCTRSQGLTGQLTSAVEDHQKLVDKVVAFQDWIQSFQDQLQEHKDTTGEKKAIQGRLEQLTELTEKSKEGEVLLTEVREQSQVVSARSSPQGQALLSRELQGLQELLGKTLTSLQEARRNLENTLQQWGAYESHLASLTQWLSDTEAELRAPQMPATLADKEALSTRGKELRNKIAEKQKSVDSFIDEAHCLLQLSGVELVRAQMSQCNARYQSLLATIKDLAARWEGMEKDQREYEKAVASCNAWLDEAEQTLSQIQTDKAAPEEKLTRLETLIVGKVHGQQQLNLASRLGEHLYQDTAATGRDQVRLELRELHERWDSLESKIADLQKQLQLQSHARSSFVDSLSQVQMWLDNAERTVAEARDKLPSLQEAQGRLHSLKTLLAGLERLSALAQEQRERKEQLAAWLEQMRERLDLCRDVTGSRPVLKTRLDKLQELEKQQPEGTCKAQALAECTATLVTLLTPRERATLEQESGTLEGSVARLGAEVEQARHALSAQLRLWDAYEEHYERLLGWLQGAEQTVQQFALQATLDEKRQQLDKFQSLLSELHATERDFDSLSDKAQELMVSSGEMRLSMAVGQLTARFQSLLETCKELVKKCEQHVQDHSQLEKKHAECAKTLAQAQEAFVEIQALPSGNKERLSHKLARVKELLQGKSEALNLVNATVQLADQVQVGSSPEGWKAIQGLLQQLQSAYEAVFDKAQNLERVLQSSQFLWSEYHEALQRLQTWLKGLAAKAEGASRLCTTLDEKKAHLRTCRGLLAELNEREQAIEDIQIKAEAIADRDNESQEMLEGVVKGHKEQTQKLQEAVKFLEDAVTQHEQLSKHLGNVRDWLSSTQEQAVALSNLGLDQLALYSNLERLKVIHVFAMPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T678</accession>
    <name>A0A9D4T678_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T678"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057821"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14635" checksum="89AE59118EF1C5B0" modified="2023-05-03" version="1">MGSGHASDDGITPREPVVNTFTAPMQRFPQGAPVWSRQYNLAGQRWLPGTVTSSVGAWLWWTPPEECSVVTWTNCGHGTPNCGKAGALRDKPIPQMAAARIQRWALLLSAYQYDSMTAVCLCRSQRTTVKMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6U5</accession>
    <name>A0A9D4T6U5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037704"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038195"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7982354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1311" mass="147116" checksum="37A569DCEF0150C2" modified="2023-05-03" version="1">MTSSSSVKELPPGDPKLTASIVSHLKSRGLFDKLRRDCLGDVDTKPAYLNLKQRIEGYITKFLSTQTWTPDMNKNHVRDMMRREINESGMLSAGMDHLVDQIVNPKIYHVFTPEVENGVRQYLGLSSEKDCSTQQQPVAETDSINQPPPPQTPALPPLPPKSEFSIDETTQDVPSSCSPKPYTEALMPDGLTDSSSEHQLMIVTESNEHTEDIPVELPAETAESYEFCDTSAEPVDTAPNETSELPVPGPVDNLESDSQAISQSGSADDRPVTEDVELPVSLDDTKHDRLKREATMNEFDRKDTDVVADMTKMEVKPMDKDKKERKVDSVKGKEFSSHSGRLDSHSKSYTSKKTSDTSRSKIQKSNKCDSDSSRESRDLLKERDKYSTSRDRGSSREETQRNRADATKDERSKGYSSQSSRSKESDSRNERKRSDDKHRHYSSSQRHDDRNRHSDRHSREDKSRDHSDSRRSHGENRRDKDRSSTRDSSRQHKSSKSSEKHGESSRKVRSHEKDKKQAYSKQGSSDNKDGETLQKMPSEKVLQPVSRNLFQGADDALFHMQMLETLRTQPAEMNANASGSSQHDHANVCHDTSLEAPTHVLQENSEENISCCAEQTGAKICESMSGAISRETSLAVIDESSHGALHTNTEKQAEEMLHEERTIDNEVQVENSEQASSSSHAAPLEQQSPTVEDRPEAARRKTHSPEKKRLRRDASDGHESDGAWSDVTVSSVHTSDLSSYDDCISVSSGDENDSAASREKKKIPLREIKKITSSSNEDDDRMSRSETEHCASDGVVPPTPSIEQATEQHEALESAKESQPQCPEHCESSSSARGLSNSPSTDVSDAMAKPKMGLRRTRKINPKYVSEEFSSIFTAGKRPAGTIDFSELAKYGKEKHHEERSSSRTEHRKISREDAPEDTAPAMSCDETDQLSDTSVNDRSRRPTRRPSGGEPRASIGRPKHKRVMAGALEGDIFVGPKAEEHRGLLSIRYPMEHGIVTDWNDMERIWQYIYSKEQLQTFSEEVCVITSLRLHKFTSALLQHPVLLTEAPINPLRNRERSAEIFFETFNVPALFVSMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAIPHSILRVDIAGRDVTAYLRHLLRKEGTNFHTTAEFEIVKTVKEKACYLANNPQREETMDTEKAHYTLPDGTTLEIGPARFRAPEVLFRPDLLGEEFEGLHQVLVFAIHKCDMDLRRVLYQNIVLSGGSTLFKGFGDRLLGEVKKISPKGIKIRISAPQERLYSTWIGGSILASLDTFKRMWVSKREYEEEGMRALHRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6X9</accession>
    <name>A0A9D4T6X9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6X9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029140"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="12872" checksum="A78AA34FE22EA17C" modified="2023-05-03" version="1">MRWLAADREDQSDLASDGGARGSSALDGPFNSTMVEGGVPIHQVPSPSTTSTGGPSTRTLVPDTEDEPLTDVPQPMASPPPPPESSPTVVIPPCPPRVYRHMQLRELRRVPYSWRLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7D0</accession>
    <name>A0A9D4T7D0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7D0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67857" checksum="696B67A9E754C072" modified="2023-05-03" version="1">MSVEGEDVTQQEYEDEAGWRVVKRRGRANERITQHGAKDEATHFSSVNAANNKWSKEQRARQIMAASRMPSLPKEDYKISVRPRDGFKVTDYGINRLECCVANAAEIPRKETEEDTVCANYKQNILVVSTPSQERAEKYRAIARLRIGDKEFEANAYESAPEDTSKGVIRGVTHEVSPREIVEMLVTPRNPTVLMAKRMGNTTNVIILFDGHHVPNYVRYGTGQCGRLGHRADVCPNPNSRICRGCGTENPPQDHECEAKCQLCGKDHPTADRRCKARYKIPYLLKRRRWERARREEEEAMYYEKEAEALYRQGRHDWRQQPEHQARDRSRPDAFPKRQAREKGRSTSNNKTRSSSRSRSRSRSRSTSMSRPNTSTTGSPRPQEGAGSQSPKGTSSINGTAGPFKVSWADAASGARAEAQAALQNRIKALENELAHIRQSNVAFMDEIRKLRAENELLKSGRVTRNEETSRVVAEEKDAAMKDEAAVPIKRKTENAPIKTGIKKPKPAKTLPGGQEEFAKNIDAKVEQMETTFQTKLEQQEVRFEAKLEALGKTILQQVQQMVADFDAKLAIWGPQTSGGGPVKTSIKPYTRTPIPAEASENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7G3</accession>
    <name>A0A9D4T7G3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7G3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039603"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039795"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042062"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="699" mass="77372" checksum="9B5409D630CCB8D7" modified="2023-05-03" version="1">MGKAFGGHPHPPPEEPKVYVFPSRKGTVVEVCESAAIVEVREGSSIRELTVTVDCFYYEGRPFLNNLARVLHKGAMLNVDYMVGRVGGKDRVHCDLAWLGPKPQGVPCLSEDEFRQQLGGRGTTIELNNLSKDAPRGPAKQSLPHIDRPQVCQPPPQSSSLAVDTRPQTESQVVDTHSQMEAYQPPTKSLSEVVDTYRQMQVHKQPPQSLSQATNARSQMDVHRQAPLPTSQAKICPQMETHQTPPQSLSHNNLPTDGSVPTTTTIAVENCGHQPSMDNTHPPMEAYRQEPQVNICRQDTRQSPTQSLSHIGTRSQMEVYQQAAQVMSQVNICPQKEANQAPMQSLSHMNIRPQTEGCRPLPQSSVSQVANINSEMEAYRQPPQVVSQTADTFSQMEVHGPLSHTSEPRSTDSSHLPKPTSSETSTRRGSFNVSDEMYNRVVEIVREQNVALIRAEIREVLRDVFNSQGLKDLHGHRTSGTRLQGNEKFSRHLVSTYLRIPFHQGTTSDSRFYLADVECFTAAKHLLVHIREPKHRRRRPSIPLGSLLTCRSSPRLLQMLLPPGCHSKRGAWTQNSTGGGQPSGFDVATASVLPETPPATAQLEDNAHGSRWKMQQNVSTFQGHEGNPQDMQDLGISFDDSLAEGDELSEDDIRQLGLFGTHHGDEGAALSSLEIKIPVRFFGIFGLEGCLRNQTVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T869</accession>
    <name>A0A9D4T869_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_001076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T869"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035061"/>
    <dbReference type="OMA" id="PFFEQPE"/>
    <dbReference type="OrthoDB" id="8197458at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7981766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="313" mass="34864" checksum="BD061E3D7EC2A254" modified="2023-05-03" version="1">MTMDGLDTLSRDCLQFNLSFESFKATGASGLAPPEGSDDPLNTPVSTTAELITFFATDAVIPDPVPISGEPAHRWPERPASPLRDAEQPKDPYGRLAYRGTFTTAWPGPDAAPFFEQPEPFPPLDSFKAAPYTAETEPAKYPWFAYEHAAPPAPPSSSSSSAAAKPEEPSATLAEYNQATSKGHEILSQAYQNSPVPLKLVPVKPRKYPNRPSKTPVHERPYACPIEGCDRRFSRSDELTRHIRIHTGQKPFRCNICLRSFSRSDHLNTHIRTHTGEKPFTCDACGRKFARSDERKRHGKVHLKHRLKKEDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T870</accession>
    <name>A0A9D4T870_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Recombining binding protein suppressor of hairless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_021927</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T870"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050130"/>
    <dbReference type="OMA" id="QRQDMPH"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990433">
        <property type="term" value="C:CSL-Notch-Mastermind transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01176">
        <property type="entry name" value="IPT_RBP-Jkappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000001">
        <property type="entry name" value="Recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000074">
        <property type="entry name" value="Recombining binding protein suppressor of hairless, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
            <begin position="147"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="13">
        <location>
            <begin position="279"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7976960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65893" checksum="594C67DF3B8BA733" modified="2023-05-03" version="1">MSDVYLTEEQYAGYHPSQSNYSSPHDDGPYGAGMAGYGDYGRGSELLMELGGQPVDMSSPPARYYKGGGGGGLSDQEPSALLGSVAKGPGPPPAPQGSPHLGLQAPRAQLPPSPVASPVAAATVAGGESRLSRDAMDRYLRERGDMVLVILHAKVAQKSYGNEKRFFCPPPCVYLLGDGWQRKRDQLLRAGETEQAAQLCAFIGIGNSDQDMQQLDFGGKNYCAAKTLFISDSDKRKHFMLSVKLFHGNGEDVGVFQSKRIKVISKPSKKKQSLKNADLCIASGTRVALFNRLRSQTVSTRYLHVDGGNFHASSSQWGAFTIHLLDDNESEAEEFTVRDGYIHYGSTVKLVCSVTGMALPRLVIRKVDKQNAFLDADDPVSQLHKCAFYMKDTERMYLCLSQEKIIQFQATPCPKDVNKEMINDGASWTIISTDKAEYTFCEGAGPVRGPVTPVPVVSSLHLNGGGDVAMLEINGENFAANLRVWFGNVEAETMYRCAECLLCVVPDISAFREGWQWVRQPTQVPVSLVRSDGVIYATGLTFTYTPEPGPRHSGPSPYPALVHEILRPANARTHPPAPEDHGITAAQGYGQHHAMGHYPHHQGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8N6</accession>
    <name>A0A9D4T8N6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8N6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030447"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18494" checksum="F22EF06A01E3E8F8" modified="2023-05-03" version="1">MSASPWIAVTEQLMEEEDQCVPAYRDSSVTPERYAGATHSTTRELSSGRKRYEPPLSLNLSEITLIAAAATQSADDEDGNYSLPCHAIFTEKSHEDQPGTPDPDCDDTGECDSHTCRRNIARCISERCKQLERRSRRCFFSPAYFTAGVGICLLLLSLRHRYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8X1</accession>
    <name>A0A9D4T8X1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8X1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029244"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="159" mass="17829" checksum="5FBBC32A340A42D0" modified="2023-05-03" version="1">MNVATQHEEAKLALPLMRVHGRPWYRQKFYYQGESAARKVPVGELPVDLTPAAAAGEYKDAAEGATTKGGDTSPVAEEAMVVHDGDNHDIEARMHTSSWATEHVGERRTLHTLQMADFLEQEFLAEQVRSIDQLQRLITQLQNMDTGLGEFLLDQQLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA79</accession>
    <name>A0A9D4TA79_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA79"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="179" mass="19822" checksum="D1D4DC376FB45395" modified="2023-05-03" version="1">MNPYIADIEINLDAVNSGLRAVKALRCAVGGHGNRMCKILKAEWSRQARLYRIHLEVQLLSSMGEHGNKQVHKEFNRLASQATEFLWQSALLQLRAHHRPKKKGVPGNRIFTEGDVMLPEEVSKCLAQGPKFAVQPQTTASERLSLVRKVSSLAPASEMDRCVSSGVDVLLRDNSDPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC92</accession>
    <name>A0A9D4TC92_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC92"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048376"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26144" checksum="64A54AE37290F716" modified="2023-05-03" version="1">MRKRAIPRRETGGFTFDSPHVRVCEKYFDESGIGRVHQWLVGGGVVTSQRDVPKLLPGAVPRIAQVAVELVDSDSDQEEFDDIVATLAVKLVRTDRSRIPRACTNQCGENLLYCSNSMYSIADRFDVTESSAHACIDRVPNLLQSMSEEVITWPDQQQQERIKEGFLAKSAGKGPRSTIGCVDGCHVEINTPSVPAHSYFNRKKAYVTTKTDSQTYSLDSPVRRMTPGFSVKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCL3</accession>
    <name>A0A9D4TCL3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001073">
        <property type="protein sequence ID" value="KAH7985131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCL3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056601"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7985131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17801" checksum="D578CC6D8B30392A" modified="2023-05-03" version="1">MYKRYIEPYLRGWDGPRSKPDRLSQVQEQIGALTEAIQQLREAVASLESAVAEDRRLRKPAEALDSAKQDRTISELKSEVLSVKALLLSRNQFPSAPKVTPPVPSIPTWQLSSNGAEKAENGAASESSESEESEEQSSKSAKEPMESRKEEVLHNRPTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YS76</accession>
    <name>A0A9D4YS76_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000228">
        <property type="protein sequence ID" value="KAH7986883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YS76"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37952" checksum="AC699D992598D16C" modified="2023-05-03" version="1">MVLDPSCARDRPPAARKRLSSSVASEAADSESDVKSDDSEAFIPAKHRRSRRKSSTSSSSEETVIYSNIVITTVAYVPVDVSLCGVSTRAYIPQGANVTAGVISDVDLELQDDVLKSIIVCTPPCKINSSDSVRQREGQRRNFLSATSWPALPSKTSEPVSEKIASHKASEPASTKAPPTVENSVNNTVPVEDDAHLINLLKMLVNVIRALIAGRQTPAALAAEQLLEALVPVSTAFAKNSMNSRKPRPFVLQWNVRSLRPRHADLVLRLLAMNTPPDVIALQESNVRKDELRLPADPWGSDHLPIWLTPEHTPSRQTAAYRVTNWDKFRQLLSEAPSHDKMFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDV7</accession>
    <name>A0A9D4PDV7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055768"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="534" mass="58135" checksum="4CEA31B0A38F375A" modified="2023-05-03" version="1">MECDGAETPVDAEEIDRDSGWITVTRRRSEAKKAGGAFGAKTPASQTNAEEHMPGRRGFGNVKKNIIRGSKMPPLPREETKVVVRPRGGLCISKVGPSVVAEAIWGAAGLDPDGRNMDTMCPNPLQNIMVVSTPSTENVKRYVNVEAITVAGQDHEVSAYVAAPHATCKGVIRGIPLSDGPEVIDRKIVNAKNPLALGAKRIKSTGVIIVLFDGYKVPNYVSYGGILLKACRQAIQQEEDHVCEPICSLCGGKHLTASRECKHRYLTPYVVRRRRALSARATRESSTTVVNRTSPDHRHLEADLDRGGDPKPEAAVRAALPPGRVKGPCSRSGARSMSKTRSESKGGTGPHSSSRARSESSKPAQGRTDAAGPGTDPSPKADYGYTQGLQLSRPVHANEHQGRRKSSLTWADKELLPTEDAGITTWADKVKGQTKALEVRQREEGRIALGVHAFTPNGAVQDDLGSSSFEAREAVAKLSYERRLSGPPDGRWAREVYKYVHLRSVRTKWVARTRSLSERHRVEANRLMASFQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PG52</accession>
    <name>A0A9D4PG52_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PG52"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="17758" checksum="A00A015DC7462F82" modified="2023-05-03" version="1">MKEMSKQPLDLAVAPASDNGGDRGAGIGNPAVLRDDDCAGSGTLRSHSGAVTSSDIAQERARETATLDRLDSTPVTARKTDLPIKKTATSASATQPAASYLIVDLDLVNQLLGFTLCKTCGRDVKRATGDRNYGLATKLALLCKCSKCLKDDSSCLNGTATTSVEAHDANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH26</accession>
    <name>A0A9D4PH26_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH26"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030928"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="455" mass="49524" checksum="B52F15A1F96721AB" modified="2023-05-03" version="1">MSEPPAVKEIAEATPRSDATEGAGQMTTFSVALMMMTAALGAGLLHFPAAYNIAGGILMATVMQLILVVSMGGTILTLAFCSDVKNDRTYQGILLSMCGTKWRYASAASVLLTCYGVCVTYLIIIGDQYDRMFASLHGPDFCHTWYMSREFTITLTAVAIVLPLSMLQHIEFLKCASSLGLVAMLYPCVLTGIAYFTVRRPDDLYIKVWPTSAHDVFLSTPVFCFAYESHEVVISAYAAMRQRSMRNMAQAIAICMAILFVIYSTVGCFGYLTYGASVRPDIMLMFDATQAWVLIGLLALILKMAVSYPLLALCARDAIEELYLELRGGPPEDRNEVHARMMKLSLAWFASTVGVAILPLDIGVAIKCLGCLSALNVFLFPGPVPALTTDLALFLLLGMCLLGYTQLKDSSTTYRHCLMLVGALMVIVGAVIFVGVLLHVLLVDLVSRHANHLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH84</accession>
    <name>A0A9D4PH84_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033786"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="307" mass="33818" checksum="10F582192A7A6083" modified="2023-05-03" version="1">MTCDQAVSYLGSSAPLWWCPSGSLAALVMEFIALARLSWIAGPKDYLAEQMGFRRNCSPADSIADVPFTMEEARRKGEVVLLVRLDVQSAFHVLTHIVRRYLTQCSLYADDVALRVRRPRRNLTPIRCSLQSSRDVVATFVEATGLIVSRTKMEALLVHPKVAARRAIRWLVLGDWPIPTGSSGFLFYPAPSTAPAAAGRAVGAEQPQQRRAPACELYQSAVAKIHDRQRGHLLLFTEWSVGTAPLERGCLRYVNERDHHPVPPFHACSTAVKLCGLYLAADYLAVTTPKLPGVTLYGCRPALPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ91</accession>
    <name>A0A9D4PJ91_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_012002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ91"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052325"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="200"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7943859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="296" mass="34437" checksum="46AFEDA476CE32F4" modified="2023-05-03" version="1">MKDTMTAVELKDLGNKLFTARKYEDAISCYSKAIIKSPSTATYFTNRALCYLKLQQWELACQDCRRALDLDPSSVKGHFFLGQALQEMDNYDEAVKYLQRANDLAREQKLNFGDDIACQLRLARKRRWQLIEEKRLQQEIELQTYLNQLILLDKQKRVQEMKMMGTRQGDIERVEAALDKYISELNNIFAKVDERRRKREVPDYLCGKISFEIMREPVITPSGITYDRRDIEEHLQAIGPNPNQDASLTMCSLLIRVGHFDPVTRTPLTQDQLIPNLAMKEVVDGFLAENEWALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJU8</accession>
    <name>A0A9D4PJU8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJU8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="98" mass="11279" checksum="94639D462927C18D" modified="2023-05-03" version="1">MNPSSSEVGGSSPGHRRHGPDELTPVYQRSSRRLRVREELKRQRLDHSAPAVSSLADVVREEVRMAVRDPNPFGDLSTMPRQKRHRCDRRDPHLPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK40</accession>
    <name>A0A9D4PK40_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element Tc1 transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK40"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033937"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7944208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35212" checksum="B5017C9C412EDBCC" modified="2023-05-03" version="1">MTGRPRSSVNRIVKAFSTEARLTNLPRGHRPKVTTDSDGERIVEAARRNPKMTAKEIRNDLGLVASTQVVRERLHVGGLRSRVAAMKPFVSSENRIRRLLFAQEHRSWTVEEWQNVIFTDESTFASRWDQQQRTWRTQGTRFDAPNLHRVASSGRCSVNVWGSISKDGLGPLVRLDGLFRAAAYTDLLDTILIPYALNGPFKDGLFFFQHDRSPVDTAASVKRLLEDRCVMVLDWPPQGADMNIIENVRAEMKKALSRRPLHKCSSDILWAAVEEEWQKLARSCVAHSLYESLPRRMAAVLAARGETTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK95</accession>
    <name>A0A9D4PK95_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK95"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027693"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055663"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43425" checksum="4483775500C90DFB" modified="2023-05-03" version="1">MGLSHIEKAREAVGQNFAIADINHMFLKNAQKKAIDRASHDTAPKAAVEIAEEFGEEGDEPAEDKVGSGIVLVDFRDSASMRELDGATKDLGGPEAKDGKAEKTRKRRKRKKKRNDDEQRGGVGAKENKAIVDEAIVVDAVAHVRDNTSEPNPESEREDRTEEETKKAEVEKPAADSKEDEETKGDAAPPAKKAKAEPARTRPQRKTKSAGARRVRSLEATAKEGEALLRELVHKDSRVPDSGCRRTRSQTRCTTAAPAARQLARKPPAKPARALVHSRFLYGLPFLPMTPTQLDIIESINKTCIRIATGLPKYAKLEDLYGTGLLLPIGDYVEPALQAQNERLKLTRAGRAIRSELGLSNEDLPQILPTIPPWEDITVTDNRPLPKHMNQASDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKU2</accession>
    <name>A0A9D4PKU2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKU2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="274" mass="29054" checksum="2D4683CFB835D1BA" modified="2023-05-03" version="1">MPPRLCPPVPPFHPAYPRAWFWQLDACLAVNGATAKHLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPPTRAVPSGPQPSHDHDLPSPATSLSTSRPATSAVVPAPDDQPDDVQVPTPEVPAPDDVLAAIDQSATKCVSSTTSADGPSGMPAIRPSSLSSPAHDTSLTSASTLATLPPELEADTDNLSPTVRPSLAEVSPSTDPSTSFHRLPSSAPLASSDRRRPRRLPQQKFVPLTNSGRTCRTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLQ1</accession>
    <name>A0A9D4PLQ1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLQ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038046"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050922"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="530" mass="56722" checksum="0A7BD8175011190A" modified="2023-05-03" version="1">MAAPFANLPPFLNAPGKPPITWHIWHKIFQVHLKAAGGSGWEDERRASALLCALGIEGQRKYFAAQEQLEAEGAVTASGSGTVPKTEAATATTYDTVLQFLDGLFAETTNVLAERHLFTSRKQLPGEMFLDFVTSLKEKALSCKFGATYDDRVRDQVIHGVANAHVRAKLLSYGEALTLQKAEEVGRDLEALNKANAAFGENERLLGSHSGYCGSIQCVAAAQNCGSAASLVPHVTQHGAGFPPGAGGRVQDGSAGSTALAQCCVRCQQVQQLAPKPQVGPYLQHHGKRAFVTFYVTAHGTSLLGLDAVQQLGLLIDGATLTCRPATPVSSQLPAGVPPAFEHLHSGALGRVKDYVHRAKRRQHIVPLSAKLCRLPLALRQQDAIELRRLQDDDGRGRRPHSRLRISNQVFPAQAIRGGPAVQCDSTSAEAQLQLPATQYHPLGLQEESPGYSSSPAVNAPNSNTGEGSNATGSSESAHGSRNPPSSWRDWDRSLKLALDSHHTQSLPGGPGSRRPQRTRKPQPTALARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM12</accession>
    <name>A0A9D4PM12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052564"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056039"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015116">
        <property type="entry name" value="Cdc42-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09027">
        <property type="entry name" value="GTPase_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc42 binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="4">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7947169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25674" checksum="A197AD713975C70B" modified="2023-05-03" version="1">MDVSGRTWGNPGSIDELYLRNPMEPPDLLGLPPENDEPPPPLAARLQELARRSSQNNPIAKRTTRMRQYSYNRFVDDDPGREGGQASPIRLLASLASSTASVLEGPLKLRPQSLTVGVHHRNRLASHNRKILQEQQAEGKALEMCNRDFFPNIHSLLSILATLPVSTSTPERTFSTLRRLKSYLRNHMNNDRLTGLALLSIHRELQVTPEQVLTEFCKLPRRKNFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMC3</accession>
    <name>A0A9D4PMC3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_007565</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMC3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052285"/>
    <dbReference type="OMA" id="NYHKLAD"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="14">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="112"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="465"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7947119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="592" mass="63965" checksum="453FAFABBDEB3206" modified="2023-05-03" version="1">MPPIHNGTDPKDTIEKIIRGNKVVIFSASGDPTCAQTKEIFSSLNEPYVSIEVDDEGYGPPIQEALSQRTGLSGVPQVFVGGELLGGSEDTASALKKGTLGQLLMTGISYDYDLVVIGGGSGGLAASKEAAKLGQKVAVCDFVKPTPKGTTWGLGGTCVNVGCIPKKLMHNAALLGQGIHDSKSFGWDMQDVKFKWETMRGNIRDYIASLNWKYRVSLREAGVTYINAYAHFMDPHKLKLTDKKGGEKFITSRDFLLAMGERPRYPDIPGAREHAISSDDLFFLPHCPGKTLVVGASYVALECAGFLRAIGFDVTVMVRSILLRGFDQDMAERIGKYMEEEGIRFIRPCVPTKLELIEEGSPGKIRVTANANGTEVVEEFNTVLFAVGREPCTHSLGLAEAGVNVNPKNGKLPVVNERTNVPHIYAVGDILEGRPELTPVAIQAGILLARRLYGGSDVQCDYTNVPTTVFTPIEYGCIGYSEENAIAKFGEESIEVFHTSFTPLEWTLPKRGTDAGYLKIVCLIPENNRILGFHYLGPNAGEVTQGFATAMKLNATKADLDATIGIHPTCAELFTTLTVSKRSGGSTKQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN60</accession>
    <name>A0A9D4PN60_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN60"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045523"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056420"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="60"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33024" checksum="7B23C4D8A4CA8574" modified="2023-05-03" version="1">MSGYLGNLTRDFDVAKAERMYRNDIEWRRRNGVDDMLLSYEIPEIVKENFPGAILHPCKDGRPMWLIPAGMDMKAIKAITDMLKMMEDHFPECLEKCICINAPSFFPVLWKLVRPFLTQRTADKVNVYSKDGWKNALLDIMDAEQLPAHWGGNMVGPDNDPRCRHKVNHGGRFEEVAPSSVFKEEGVQLKNIGRRDRWELPVSVSEPGVQISWRFQTASGDLSFGVRTEAGETLVPLRRFESCSHEPQEGCWQCDTPGTYILEFDNSFSWLNGKKLAYVVNTHAVNENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP67</accession>
    <name>A0A9D4PP67_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP67"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7950756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14366" checksum="F3D10EAC5F7F7A1A" modified="2023-05-03" version="1">MYRLARGCLPITYRPFTKNIQRGVCPFCQSREDLAHIFCECALPKALLRKVADLFKLPGIPFPTVRYLNPLPSHAVNQFVLLLVECLYQVWLARCEAVHGGGFWAFTKYLQKCGRRFGSISSVSGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQE9</accession>
    <name>A0A9D4PQE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_001944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQE9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042977"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF171">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039328980" evidence="4">
        <location>
            <begin position="23"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7950818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="404" mass="43938" checksum="4D2FADB5BA3B8FE8" modified="2023-05-03" version="1">MNARMPLLLLLSSLHVLPIALAETTPEWATASHVGGSGSQLRLVHVAVLFRHGERAPLTSFSGDPNRHYTWPMGHGQLTNRGRQTMWALGKWLRARYAHFLTSDVREVSARSSPVPRCFDSVAILLYGLYPAVDKERQWKHGQDWQPVPITSVPDGTDKYATPCLPRFLESLSALYATEVPLSLVGEQAARPPSPRAEPDPATAGPRSFATASNILEFVATAANVTDKPGVARFMAIARIVDALLLIWLNEMLVELIGKYQKDNMAGALLKDFVASMKPGHAGGGVMLTQGQDETNKAPKVTLYSYHDMNVAGALVGLNGTLSGRPSCGAAIILEVFARSGASDTAADKFVRLLYKAGDQHATNIPVEGCADPCPLQKFNEILERKFKPVTRAQCGWSEHQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQI0</accession>
    <name>A0A9D4PQI0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_005329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQI0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028751"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28084" checksum="AB7A918D001DB128" modified="2023-05-03" version="1">MGPSGAGKTTLLNILAGHLGLDSSSAQRCVTVLKSLAASGRTVLCSIHNPSARLFSQFDNATCIARLLACLFFAFLLSIMYYDSGNKALQIRETIMMYLVAMMMLLFAYAGANVLTSVCYLIPFSCVCRPTGLFNAQVAVMLCLPAATPSFLFCGFFVRPRHLFPAIRWLTYTSHLYYVHRGIMYALYGNGRGELTCNEWDADVLCVPVEGDAVLDIIDATDVDLLVCSMAVLGIDISLKIFAFALLKWRLQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQI2</accession>
    <name>A0A9D4PQI2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 40</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_023309</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQI2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029142"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13974">
        <property type="entry name" value="STKc_SHIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024236">
        <property type="entry name" value="Ser/Thr_kinase_40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="41"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7948488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="479" mass="53278" checksum="F71A6ADEE8C54868" modified="2023-05-03" version="1">METTAHDDAGPSTSSDDSQSNECPKEGSPVKLNGVRKAGPYLLGPKLGTSPVCSITQCLAKKEGTDDFYTIKVLIIRSPEEETQEDRQGKMLLHTEYSLLSMLHDQDGVVHHHGIFKASLRWCRSDRAWEMRETTDGLVYTGRQQQRLCLVLDCLCRHDFGTATVDLVNLQHYVIREKRLQEREALFIFQDIVRIVTALHKLNIVHRDLKLGNMVFDKRKRKVTITNFCLGKHLINENDLLKDQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFTMLYGQFPFYDSNPQELFRKIKAAEFTLPKESPLSENTRMIIHKLLVLNPKQRMKAGEVLESVASTLAVWNSLATSGKPLQVVPDIDDNDNARGEEADAHKSPEQSASASAAATPSFSSSLAELQHPSGSNVGDFIFGTRLSIGHAPHTHKPPVVGPPAKRRQPGVLSIQRVHEDARPLTAIESMQYHNMLRHTASSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQJ7</accession>
    <name>A0A9D4PQJ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-coa synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_003076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQJ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037707"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051074"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF426">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="307"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="523"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7950893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67078" checksum="690B2015256B62DE" modified="2023-05-03" version="1">MYSQVSALSTVPYLARCLLDHPQRSRYDLGHLRYLATGTSYISEDVARRLFLELNLKSYVQIYGQTEFVFITGGLHDSPPRFGSIGRLGVGVEAMVIDNETKKPLGSMQHGELVVRGPGLMRGYWGMEDQPCTDPEGWYRTGDECYLDDEGWLYLVQRMSESIHCRNVKVIPPKVEAALLQCAHVKDCAVVGLPHLQAGQVPHAIIVPKSNSRHLGPEHYVRFVNERMPEQYRLEGGVTLVDAIPRNKLGKLVRRELVNWMLERRAHQMTTIVKSSFGDCAPDFRKNFGGYILEHLRLNPNSRLINATSYDERTYGDIANQAEAVHGALESLGVCAGDRLCLMVDNRLELLPMLVGAACANVGVVCENPGYPVDVFIEWMKNIEFTAICCELSNVDSALELKARLPTIKHIIVLGEGKNMPTGAEAVVVLWSQLIKMGTKARRLSALSVEYQANRICYIAPTSGTTGKPKTVVHCHDSLVANVQSIRILSGGRHGNQGVTLRCDPDSANQVTYLVNFHLSKPQVYGKAEIAFVTGGLHNSPPRFTSIGRLGVGLEAMVIDNETKKPLGPMQHGELVVRGPGLMRGYLGMEDEPCTDPEGWYRTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQZ4</accession>
    <name>A0A9D4PQZ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032317"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051698"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17691" checksum="831F5DA36C09C340" modified="2023-05-03" version="1">MRSGSTGCEKSAIGSGLLSLQTQSEDETKNKLSSFADLLKALPGFEHSDFWTVIHKDSKVYFLDLALHSAPTIRASVIVSTGLRIEVFFGEAVVRNCGDVLVPEKIYYDDLEVCDSGHSAQEVMEHVESAAANTLLNNLCRTENDKSPNAKNERKLKTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRR3</accession>
    <name>A0A9D4PRR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="258" mass="28900" checksum="9876657F78F1CFF4" modified="2023-05-03" version="1">MDREEYAKLMRMTNAEQYELLREIVHRQTTLGAPPLRVFLTGPAGCGKMFVLKLVMDVYNRYNDNAGPYNAFVICVSTGKAAVAVGGTTVHSAFKLTRNKKDLGLGDSELNTSRVAFRYVKCIIVDVVSMLSSDNLNTIDCRLKQVTQMLDEPFGDLDDIMCGDLRQLPPVRANEVYKSCREAGGLFGATIKWHYLDYFPLVQVVRQSNASFSALLTKIGDGRVLQDDEVRQLESRFITTEEALVRASSAIRIFHSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSE7</accession>
    <name>A0A9D4PSE7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_020173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057764"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7952215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="292" mass="31378" checksum="CE83994E899BD121" modified="2023-05-03" version="1">MALLVSFGDSNKRGRRQSADVSSEQQPGQKAIEALRNWQPSVRGGTPASGNTATELATSGHHVVCALVACLGSCAAGTTLGYASAAMPSIEHETWYDLRHNTADSRWFADILLLVAAPAALAAGFLLERVGNRLMLLLSTFGLLGSWLSLLFSTSTSAIFVARLMAGVFLGAISSSAGVHVAEICPSERRAFFLGFVEVARSAGILLAYVLGQFFTWEIQAGFCMVPPLVLMCMQRYVLDSPQWLMRRGKKAEALAALSRLYGLDVPVEFRIRSADEMAKTNSNATPIKCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSN0</accession>
    <name>A0A9D4PSN0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_022020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSN0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049913"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="295" mass="34725" checksum="9C7CD80A3221B28D" modified="2023-05-03" version="1">MSQDYPVNLYLRETWFDPRLSLLRHGVNETFVINGGDIAGQLWKPDLIFVNVKAARVQEITVPTSLVRIFPDGHILYSLRLDLRLSCTLDFQLYPFDTQKCHIIMRPWNFTVLQYTFVLQRLRGYHLIYVYLPSSLIVCASWICLWLKVEIPQARVALGAVTLLTLVSLASSVRTTIPRVAYVKAIDVWYATCIMFVFAVLSLATCTHYLVRVRLRPLCVRRVDHWVVDIYQRLVYGRRTDPFLLTMDKENKLELHRNVKTSQAFERVARYMFPILFGFFNIVYWSFYVERSYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSU5</accession>
    <name>A0A9D4PSU5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSU5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027520"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053414"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="389"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="512" mass="56523" checksum="2776818BE8356BC6" modified="2023-05-03" version="1">MPSILIMCGDVELNPGPPKSDAAKANAEVLAAIESLASKLESRHAELMSALDAVKASQRHLENKVSDITARLAAVEMKVNSFESVPDQPEGGRSVSDNAFRGESSAHQRPIDDQDDKYRRDNLIIYGLEDIPTETWSQTEQKVRSLLSDRLSVQLSDKDIARARRIGAFVDNRCRLIVVKFASLDVRNSILSQRFKLKGTGINLQEDFSKVIRQARKKLFDFGKASGRPFNLHYNKLYSDGKCYVYCAETDAVREVEPHGVTSGPAETVTPLTVTPEYVPRLPERDYTVLFTNIRSVFNKRHALSSLIDSCLADVVVLTETWLSEKVDNGDLFMCEKQYVVYRHDRCGRLGGGILTAVSRDVTSFEVPIPSPLEFLCTCVRVNEQEAILCVCYRAPSAAASFSDDLYDCLTKVVGRYPEAPIFLLGDFNFPGILWNDPCPVVTSGSSECLSFVDMCSAFNLCQLVKEPTRVTASSANVLDLVLTTAPASVSSLTLLPGLSDHAIVHFTISPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT33</accession>
    <name>A0A9D4PT33_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT33"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13077" checksum="2CC47298F9937D1E" modified="2023-05-03" version="1">MPVALRDTLRGVRFADYVEVYTGASVCGALTYEDIIAQVASAQPVAEEPEGEEDEDDEAPVRPSASAVMEALNVVRLFFSFEEGEEDSLRRVRALEQRAAAVAFREKKQMVITDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUG6</accession>
    <name>A0A9D4PUG6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUG6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057827"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7955307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22676" checksum="3A4907FC3348955D" modified="2023-05-03" version="1">MHTACVCRYSLAALSRRHSWQRAGGQTSQGSTPARHLHHPGRGGQGLPAGRLKKLLVTVHPDGRAANGRGPKLLPETGLTRRERASLLGLRTGCVWTAARRYLKGRCASAACSRCSDPETLEHLLCTCPDWQSNARQSPQPTGDRAFVPPHWSTCSSHPVPICQPSGAWRISSWRRESRPTTDTGTLTTPILAAGLLLFVLMTSAPPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUT9</accession>
    <name>A0A9D4PUT9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_019668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUT9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035942"/>
    <dbReference type="OMA" id="NSSKCFR"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15302">
        <property type="entry name" value="7tmA_mAChR_GAR-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000221">
        <property type="entry name" value="Muscarinic acetylcholine receptor gar-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7952160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="469" mass="51197" checksum="0066AECD82B3C8A7" modified="2023-05-03" version="1">MEACGGAANGSCVADSNNQSDVDGGPGAPFSPWLTVLIGLLIGLCIVLTVAGNLLVLAAFVVERAIRQPSNYFIASLALSDLLIGLVSMPFYAVYVLVGRWELGAVPCDLWLATDHTVCLVSIYTVLLITIDRYCSVKIAARYRNWRTRGRVASMLAATWVLPFVVFFVSIMGWEHFTGVRDLEPGECAVQFLKDPVFNTSLIFGYFYATLVVLFVLYGGIYRTARDMQRRSAAKQRRMQLLVAIGRRPPPQTTVDRSSSPESDDDEATSQQQREAPQRRDSSRSRGGGRRRVAGGGGGDGQDDKNSGNKGTAATAVKLVVVETSAGSGSGSTTTTTTTTTTTTAMAATARALLPGALSRESSTRSRLVSSFSKRKKEHKSENNRARKALRTISFILGAFVLCWTPYHICALVEGFCADSAGCVNHHLFYFTYFLCYANSPINPFCYALANQQFKKTFYRLLRGDLHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUW9</accession>
    <name>A0A9D4PUW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057505"/>
    <dbReference type="OrthoDB" id="10402124at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15078" checksum="162F7FAE6C7DCFA7" modified="2023-05-03" version="1">MAVVRRPLRAPRGLRRWRVPAGLDGRNWDVGDSNEKTRKEFDRRRATAAIKDPCAAEANGWMLTSERSMLPAYVVLFTLISCMLIAIAVVNILPSNEEDVSTTSVPVVPFLVRPVVPVVAGADTTTTDNSSYSTDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV45</accession>
    <name>A0A9D4PV45_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV45"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032329"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="740" mass="79585" checksum="33430B5AE39F853C" modified="2023-05-03" version="1">MPEDPLPVVADLPGAPVEPETLREAELPDEGVDVSTLPEDVQELEAAKEQPVASAIQDECLSTLPEDQQDFKLVQPSDMDSFVLPDVAQQVAAVVDPTHAVHDAETLDLEHSDDIHGNMLSPDSIQEEVQQLDPFHGEVQQSNINKEDMQPEQPLEPEHVKDGADTEMAASGLGYNQPLSIQSDDLVSIDLNSSAMQSLAEMSAPPHAADKAFICETVPEPREDTSMACAESENAHHDQFVCEILESLGTDDADDTSLGGSAESIVEKVTAEPVQQDSAVIFCELKETPPAENILDQQADESEQKVDNLCYNIPVEQQEQVQEKVFDVDPQVESSVLSGQVSEPFIEDSFAVPTSTESSHILEHMPEESSSLSADYQLQAEPQQPATTAISPASDVEQPCEQSYQHLSKEAENQCLQSQSPAIEQLLEHNSAALNEVQCMSENAKATVDETPAPVVDIGAIPENIPEADGVTEDSDSERDNEWRFVKPVEPVISQLEKEAGEALVESSHAAEETIHTEQREAASSELVTSPAETSASEPKVDAMSDMKQDSLPETKTEVAATQKQGTLPEQKASAAKVTATAKPSPASQKTKPAAKASPAPKPRTSSTDKPATKPLPTKTEGSAKATPAAKSPLKKQPITTKPITATTTAKQSSMASTTAKTGLTRKPEPPKAQIVCSHHRCTSKEASSCIFKAFHWTYEAHHVQATRKELGSSVKGQANSTIIHSTSSANIHRICNDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVX0</accession>
    <name>A0A9D4PVX0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVX0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="21218" checksum="6521E9BE44DC107F" modified="2023-05-03" version="1">MAKLVVCSIPEITSRGDETRAAIHLANAQLRNWCKRSRHKFLDINEGWRPDMMDKDGIHYNNTGVCSVAMKISTVAQAFLEQRRSGDKQLRPQTPQRHNRKSPRRSKDSRTTHKVGDAQQMATAGQQRKTPHPVTGQHPAPLQLPGLPAWVQTPTFPWTIPDAPNTMYHTVGELVRHHLVMATRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW14</accession>
    <name>A0A9D4PW14_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW14"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052431"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038406832" evidence="2">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="339" mass="35391" checksum="9051725A21EE0647" modified="2023-05-03" version="1">MFLVLVGVVATPVVVFVLDGNGELPFFGKKNETTVAELSLASITQTATPKASGAAASPMDGPQERIVALTTPPRPKSSHVTPAGSAAGSRYHAAPHHKSDSNRERVYAPTVGGTASRTTIGATAEVQALSEQVIVVPKGGVMSKLRAAGAADSAAAKALRKARLPKSSHSEVNISEQRDDNNATSTMTTGNHTAKPVGAKDNDAAAVTNEHAIASAAANDSGTTKVLPAHNASTSVTKTTAQPDSGVGVDYYDDNKNETSPSGSAEADDSHGEPKTRNRRISGEISVPTKSSKKPDVFQTEYYYDDSPSRKTEESTTQDITEPGYESVPEQEAIDELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PW63</accession>
    <name>A0A9D4PW63_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_013556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PW63"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054612"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="85"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7956919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="285" mass="31789" checksum="E193BECBEE2D9521" modified="2023-05-03" version="1">MWLSEIRGEPGYRKEARFVGHALWDEETTIVHHFDDPRSLAYPDLSAGMVLNRKALQRVAEALDVASPDDFSIDRQYEAELVPKESLTVAVKTCSQFHKDRVPVIKKTWAGDAHRVLFFSDVEDDRVPTVTVGVANVERGHCAKTLAILRHVVSHGLLARWLLVADDDTLIRHVFSYLYGILSCALNHRIPRLLDLLSCFDSEDDVALGERYGFGAATERGYDYLTGGSGMVFSRKTVERIINSPCSCSKADSPDDMTLGVCLKQLDVSLTHSPLFHQLGTDSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWB3</accession>
    <name>A0A9D4PWB3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWB3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17175" checksum="8145806FC942B728" modified="2023-05-03" version="1">MLRQRHHSSGQKYAETYSLHGVEIRTPRTSSTDRSGFRSTHSPVSSHRSLPSSLTVDDWLRRPAGNIRDRSETKQLSRRQQRTLFSERGAASAVRGTTLMRGARAATRPVFTSRRGESPEKAWPSRSLPHLRRWGPRAVQRTTPTGTQALDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWQ8</accession>
    <name>A0A9D4PWQ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWQ8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15420" checksum="A63994097CEA970C" modified="2023-05-03" version="1">MLTGSWWNVKASTISNCWQKAGLFEPSLTPQDCEPTPRDCNDDPELWNELTEKLLVDTAVTFEDYIDSDCAAARSAELTCEEIVSQVHEQDCCSSDEDDAGNAESGTTEETISSSDLVVFLEKTRSVPRVLQGCTRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PX11</accession>
    <name>A0A9D4PX11_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PX11"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="333" mass="35276" checksum="CF6EDE75DBD1E757" modified="2023-05-03" version="1">MRKFGWLTTQTTAGALVDRRGHVGRLDVSRLLSLATIGDPENTPFAERPPAMLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPDELRHLSAASSSSPQPYDDLCAVVLARYGETYRPLPGTHDFRVSPPPTRMVAPGPQPSHDLDLPSPATSLSTSSPATSAVVPAPDDPPDDVAAAIDQSATKRVSSAPSADGPSGMPTIRPSSLSSPVHDTSLTSASTLATLPHDLEADTDNLTPAVRLSLAEVSPSTVSEHDFSPTSKLCASCQQRPASRSTSAAAEVRAPYQVRPHLQDAATMTEAPEDDMPAGSQMQSKPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXF8</accession>
    <name>A0A9D4PXF8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXF8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="10870" checksum="A9B06F86F9A3727B" modified="2023-05-03" version="1">MSDFSHPYEAFGDQLATRLLSVEAMVTQRLSATANLLADLAARVATLESPSTAAPRVTPPAEQTPTEHTPSQPADHLSVRFKRNTPTSATTSDASGHVARIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXP9</accession>
    <name>A0A9D4PXP9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXP9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25378" checksum="83667C5D8EACA7BB" modified="2023-05-03" version="1">MGRRIANVVADGQGAHDGWLAGTSQAAAGDEVMMAGWPEASRPSEFILAASSSGALFETSRTMDRSSTFGPLGGLGKLGTEPKHCTNTAGKFETFGDVDVTHNLPTVRLLKDCLSVRLFDQYEPCVAKNLLRKHLGIADRMTELLWQVQLRQLRVQVNKNCRKVVCDVHVPEGFELPGSVREVLGLGPKFAQTAKRTKPELLSIVREVSKRAPELDAARMNSEGLDALPFHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXR6</accession>
    <name>A0A9D4PXR6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXR6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15682" checksum="118D643087675280" modified="2023-05-03" version="1">MLADAKIQVTPEVFHAGLLATLASGFKAKEERGFAYEATFTELQISRTVNIPLLSVGVNVSVWIDSLRWRLELLVDDATGDTTFRDFKVLQLGYVTVKTEGLWYLDRIVGITLNAFAALALEPIKDMGELVGRQKFRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYR3</accession>
    <name>A0A9D4PYR3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_020978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYR3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045231"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="110"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7957647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="293" mass="31468" checksum="0FBF46DE74A885A3" modified="2023-05-03" version="1">MAASLLNPAVLQDLALSWLREDQPSLDVGLYVVGEADCTAYLWCKSPGVLAGVPFANAVLAQLDCDIKWLRNEGEWLHPVAKVAEVTGQARRVLLAERVVLNCLARASGVASSARRMREVLNGIHWDGVLAGTRKTTPGFRLVEKYALLVGGADTHRYDVASMIMLKDNHLTAVGSIEKASASAVRIAKKMGGFTRKVEVECRSVEEAQQAARAGGDIIMLDNFEAKDLSPAAQKLKTEFPGVLVEASGGITAENVTQYAVPGIDIISSSLLIQGYPAVDFSLKVQPPKKPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYY5</accession>
    <name>A0A9D4PYY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYY5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39975" checksum="4968552044C65FEB" modified="2023-05-03" version="1">MASTSTSCLRLRGVFSDTPYLLHPSRQGKNRTLCHEAGCAAGLGAGSDTLYIALMPLAWPLASIPDAFFLLYADDLTVWTLHPDLQRQQPALQSALDKASDWWARIGLTLSATKTAFMSITNRRGRRRLLQTPICLSLNGQALSTVSTIRVLGVELDASGSASAWADAPLNNMDEIVHRRRMARHLKSQAVRAAAALAPYYNSTLPQPSAPLPEIPPWLEAQASDNRPLTRLRQSNRQVEQEAIVTTIDDSLAVYVDAASDSCVLHTSLVCPTLPETRHTCSYVTEAPFPSVLAELAAIRDGLTFMIPKVDCLSLSRLLVYTDSTQAVRELRKVTSSLDIASDVHRLINSCACPVGVLWTRRSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZU4</accession>
    <name>A0A9D4PZU4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZU4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048948"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13597" checksum="CF28E1D635F852B0" modified="2023-05-03" version="1">MGGNVALSADHIREVCNLIRSPSPSSKLHAIEILNNVSNYENLVACDEWPMLDERIRSLLLHPSTVIKRETLRLLWTMMQSGGVVFEHTYTSLLQAARDQVCKRGAPVTSQKLDRSAAPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0K2</accession>
    <name>A0A9D4Q0K2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_015191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0K2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10481" checksum="736C0A97739FE1CE" modified="2023-05-03" version="1">MPGVKISTSTVDRLLDAHSYSAKLAAQRPADRNRDDVKHSRKLYAQWLQSDGPRVCRFYLDETTTISGVPGILAGQLKGNQLSTRPRRQKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q173</accession>
    <name>A0A9D4Q173_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_017257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q173"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040803"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7962630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19554" checksum="53643DAACF20AE38" modified="2023-05-03" version="1">MLPESDKAAPVPLTPQELAVLAEIDSRLFGFWKLNAPENFKKKALVLKGVRHLEQVLIANYQRSKRPQGGDADTAGPASAGTAPALDSLLDHTGTDGVISGGHDRKGFQPSTPAAPKELDPKTYCKLGHFQLLLEDYAKALSAYQKYYAMKEDHWKDEPFLYGLGLVYFHYCAYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2E9</accession>
    <name>A0A9D4Q2E9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2E9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030509"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="476"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="588" mass="66603" checksum="794939F202ADF70B" modified="2023-05-03" version="1">MKDGTDDGFLRWPLHLWQSCRLKTGERDAFANFQRLLHIHGLGGYPYRNDLTGDVSEAAARVLVHSAVPALANVEITKHSLGPGKSAQWAIRIGPPKTLFRDFVKMREVNTDWFHSAAERTHGLRDTTHLFKIEQALVDLAGSWMAVNNYVVSPVSALLNTHHWNWLRFLRTAFKGVMRVRGSTLVTVKGDPFQRALVALIERFGSGNVLNYLAFRVYVRYSPFLNLLEFLELALLAGARHPGWEDGDPLEEAADLRCLRVLSKSLPEPYAYLFWNAELRNQRRVRDSTDALVEDVIAEAVRRVREDLNLTSTVTNRFRDGMFKLRRQVFVPKWFANVNSKASYTRRFFGKGEGQPCLMLMHGALDSAASNTFLRMVNGSFETSWRGPSLRDTPWLDFDNGYLAVPPAAVDKNFTKDAFFIRHVPTLGIDLAREAFSRLTDLDLVSKIGPPGYVAHLRLEMLASCLHKQSYGNRGPGEVASREDARDLLALPVALKVFKQNAAHGSHRFTFRDSRVGTYVTERLFFYEFALDRCESYEDSYFHQRLHHGVRSPAPYFVNGPLRNFAPFAEAFGCHPGSTMAVKNACAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2T4</accession>
    <name>A0A9D4Q2T4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2T4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="18022" checksum="C7A32E06C0BA5116" modified="2023-05-03" version="1">MELLIHLMGVVPFWPEIHYRIVEQTRDMADTLMYSISAAIQRSINESEWMDAKSKDIALTQLTKIKVVLGTSREAETERILTMLYADVPAVTSQRLELLAPVLVVAVNVEHTDSVLTLIAPLCVKQHLHLYMTDLAAHEFQVVGEELPSSQRGTLQRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3C5</accession>
    <name>A0A9D4Q3C5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3C5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="11791" checksum="51E416454D386A82" modified="2023-05-03" version="1">MDRIKGKRATQRALHTRLRNEASQLIQSSQFSALALRVLHDRQTATTDYGCSTNSSRNTSRTSKLPRTTCRSRSMKTTWQQRCPFSLITSDNFNLKRRRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3K7</accession>
    <name>A0A9D4Q3K7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3K7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="25113" checksum="FCD4566D29C84893" modified="2023-05-03" version="1">MSVPGTSSAGVSPADPEAGFSNQDHDVSPDFSSDDTSDTIVAALDSVTRAGPSTDGVPSAALLSGHAVDAGLAALWSQMTAHQRRIEEILFEDRTKISNSQRALIITETNGMIKTCAEFQAAAALRDGVVQELRRQLDESRREAADLRIRVALGGVPVTARSFADVVAGRPRDEGVLSASSGPLAGPGPHSSFNGPPVFQDRLGSPVQPQQVAFITPDGLRRVKNLPSAAPEACLRDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4T0</accession>
    <name>A0A9D4Q4T0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4T0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026207"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057159"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="469" mass="52990" checksum="CDDBF42D6879FB8C" modified="2023-05-03" version="1">MDGGTAAGWDGIPMSLVKAAGEETRQTIRELLKKIMVNSEIPESWKESRVIPLYKGSGDKRDLKNYRPIAEQGRAVTTRVPVLIYADDIALLAHSPDELQALLDICGDTMATLHLRFNPQKCGVMVSGPKSYSGEAWSLRGSTLQCTDRVKYLGVHLNTGPRYLEQHEHALRMKATRYRGILGRQTLWAFNRYEVMRGLWRMVAVPGLTYGNAVLCISSGTREFLERRQREAGRVALGVHRQTPIEAIQGDVGWSSFVAREAVAKATYEKRFTRLPSANLARQVWVHTIFASCSTKWARHTRSLRDRYHLPTVCLESTQGDVKVAVPAVSTRQLVRQQEREEWVRTAEKKSSMTVYMMGKGDIAKEAFFDNSRGSGLLAEARSGVLRTRHWRAHYVDGQQTQCILCNAAEETIEHIVLQCPKIHPPSETTSLQTALGFVEGEDQHKGARTHVELTKQRLEHWWRYGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q618</accession>
    <name>A0A9D4Q618_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q618"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049580"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7968675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24680" checksum="FC85799EF28D282F" modified="2023-05-03" version="1">MATKVFRAVIMGPPGSGKGTISEWIVRDFALKYLSCGELMRQNVRNKTQLGLEMAPYVEKVTKLILHEINNTYKNDHWLLDGFPRTVPQAEALYQDTALSCVLNLAVPEEEITKRIEGRWIHAASGRTYHTEFNPPKVPFKDDVTGEPLEQRADDKPATVRARLATYRAQTEPLLAYYDKKGLLHEFHGTKSKEIWPHVYKYLSSLRKPVRALSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6B5</accession>
    <name>A0A9D4Q6B5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6B5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12825" checksum="9293547CC376BA1C" modified="2023-05-03" version="1">MVMCAIFGYSNRSETRGRKQSTNGHFFSIPKTLENQCERSKGLSTKRHSLWLARIKRAELDIENPNLRVCGVHFITGKPAKLFDETDPDWAPSLLLGYSAMNTDSSRHRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7M3</accession>
    <name>A0A9D4Q7M3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_017497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7M3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026691"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028854"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033080"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049377"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="663"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7969378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="949" mass="105575" checksum="315432DEDF8FFFEA" modified="2023-05-03" version="1">MQPTRKGNSVAVDTSPDLTLTGSGTSATWCNTNEDLGSDHKIIEVVVEGGPATPRKQRVEAVNWDSFRDLRDDPTPICHIAEWCDGVLRTVKAATEVVETEGDNEVVDRRLVNLWRKKKGLENRLQRRRWDRNIRKQIAALNRQIEEHAITLTKQNWGNVCQEMDRNMSTAGTWRLLRHLLDPDSTKAASKQQLERMAHQFDGSKKELLEEVRKRYINPAGSEPLPDYGGRESSALDAPISLAEPEVGIHLYINGAEIPAVDSIRVLGLRIQANRKNHEMLARLEASSNQTCRLIRRIANRHAGMKEANLLRLVQTFIISRIVYVAPYLKLNQAERNKLDTIIRKSVKVALGLPPNTSTDRFMKLGVSNTLDELIEATVTAQHQRLLGSKTGRAILERLGYEPKREQVRSKDIPGQIRDRINIPPLPRNMNPAFHEGRRKARAEALQAKYTGRQDVLYTDAAEYENKAAHTAVAVRDNGALMACCTVSGVETVEAEEVAIALAISQKGVRVVISDSKNAVRNYESGRVTETAVPRRVCLEPFVSCADQSSCVLKKKFCDGKFDCKDHSDELGCTKCAPPLIKCATVNRCIDKAAVCNGINECEDRSDEQNCPDSSDCRSREFTCKSGHECIPMRWVCDGSEDCEDGSDEEMCHDKGNNLPFRSAGSFIPGKTGEPSEPVEYEDVDDEKFHEEEADSALHTDGKKGQHRVVEGNAEEDDISDPPKFKTATYRPEPCKADQFRCMDNGECIPMKWKCDGNEDCTDGSDEKKCTAGEGEGMRLADKRVNERADAFTVSPVNSFPLLINKLFLIYICAEKVCEPAEFYATCGDGVTCIPKTSVCDGVADCPDRFDESNCCEYTKQFPDCPADYFKCKTNGKCIMNILVCDDEDDCNDGSDEKNCVKQCPPTHFQCESDKTCIKRIFRCDGDVDCEDASDEKNCPVGGPGGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7R9</accession>
    <name>A0A9D4Q7R9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_022635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7R9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034057"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="70"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7969924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="18687" checksum="4577DD37269AA087" modified="2023-05-03" version="1">MLGRPWFTSSSKQQLLDKTRLPIMARTKQTVETARKSTGGKAPRKQFAVKLMRKVTPSSATVKRPHRFRPGTVALREIRRYQKSTEMLIRKLPFQRLVREVSQDLQLNLRFQNSALLALQEATEAYVVGLFEDSNLCAIHARRVTIMPKDVQLARRIRSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8C0</accession>
    <name>A0A9D4Q8C0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8C0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030041"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF1">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="451" mass="49629" checksum="EB729A37907076D5" modified="2023-05-03" version="1">MKGGPAEKGGYKEYLDNHKMGDAGSPADGLEGEATEVLWEEAASDAREPSTEGDEGEKVRLPWHIETLVEALKCTTSLRCLDVDCNLTLREVRLLLEAARDCASLKELHIASLHLTNLEPFCQALEETGTAHKVKVRSCTSSAQYLVPLVIGMEKAPPPVGQLRLNCVDNKSLHDACWALSNDSSQHVTSLHLHSTTLCVESDAAQELGSYLASTQCLRELDLKLPKLSPWSDLVVAGLAQNNSIQKLKIKGIFTSADVGVLCDWLTESQRLHNLEFWSTSTIAGLLVDTLAESLEESYALTRIKVVECWKNKLPWQRVKSLVRRNAGLVQCAAGFALGSELTRAALGYELVAPWHPQLLGAIQCMGSLTQVEAEKRMKSAARRIHSKFWQLAGIVYEELVCHELPPDTCGDGPTRQSVQLDQLPSRILEHICSYLKVSDVLVTKSATRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8F7</accession>
    <name>A0A9D4Q8F7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">La-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_022349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8F7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033591"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008187">
        <property type="term" value="F:poly-pyrimidine tract binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7969828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47243" checksum="D937DD6552ADB638" modified="2023-05-03" version="1">MAAVVASGHAQSGGGDEAKAAKDTNGSYAQAAARVSSREPAAVSNGLTDEGSNGAPAQGLGLSSNMVRPSSCAQVAAEVPRTNPWVKRNAQAACSASRAAGGHPGASSRKAEEDWPSLGPAAAQNEASHQHSEDEDSAKENRDGATSTTPDSSARNTPRSGPRKGNKQKWVPLDIEPAKPRKPAGHEARPGSRITEGGERRGRSFRGRQRGGRTGRSWNAPRTQSSNRAPEESFAPGAAAGPIASSFLGTYYFNQGYISVDEATLREYVRKQVEYYFSEENLQRDFFLRRKMDAQGYLPLSLIASFHRIQALTQDVALVMEAVRESPLLELNDVKVRTIKDPTRWPLPQAPLHPDVPAFVPGQPYPPAADAGNEADTEEPPEDQGWKEVRRRNRAHRARTASQSQAAPEREELEFQFDEELQRAPDGRNNTFTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAH3</accession>
    <name>A0A9D4QAH3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAH3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048790"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="36542" checksum="92F6F076033CE768" modified="2023-05-03" version="1">MQICKVAVATLSYDQMVDLLKTSVMVSVTVVPPHKDGSPRSYFGPDYDSSAGSDLGSPGGSTSGLLQRGGPAPAVGHRCRRMPRLEQVTPRSGSGGSSPSLASLMLLEPLPGPLVVSRSELSLAQLSSHEQRQLRTGSGAGGAGHPSSSRQSRQHSPLDPSSAAGRDTQHHHRSQGDLSSLGSSTFSGLERCGPLVQPVPQHMGSDYQSDSSNELSTCGSSHLGSPLPRRGLQERAPNHSPKIRLGCRVVSSGSAVTTGEEVTRSPLASLRHAVPSTPRSASATHPLSSAGPSWSPSSAKGGGSSAGSSAGSAGGGSTFQEDLLRLIGPDYLDSDSEARTTDLIQASQNAFVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBY7</accession>
    <name>A0A9D4QBY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBY7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037448"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039657999" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16504" checksum="CC88991A42121A9E" modified="2023-05-03" version="1">MRLLRAVFLLLAATAWSAQCLHLRGTFRTGQFFTFLAKFGFKKTDRHDHENTLGYIYGNVTATSAKRGDLTHRGTLVVADRDNFLAFYGNRTQGYADGSSASVCDLMFAGINRVAFDSNCNPNGTQDFLRTYPARLESYARTRTSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCS3</accession>
    <name>A0A9D4QCS3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCS3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052400"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18243" checksum="1A0C793D06184141" modified="2023-05-03" version="1">MADLIGKPPGFWNHPGTPTVPWTRWLEDFETYLLAAGSESFSAERKAALLKTLLGAEGQRQARVALAAASETPGSTKDAYSSLVQTLTAKFSPPEAVSTARLSFRNLTQGESPPQDFLFELQDTANQCDFGELKDQMLLEQLLIGLTSTRLRERLLVEEATINIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD46</accession>
    <name>A0A9D4QD46_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD46"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033495"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047477"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06148">
        <property type="entry name" value="Egl_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="365"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="776" mass="86019" checksum="E662C1A0D6A7EAA6" modified="2023-05-03" version="1">MAQAIWGREGLAERSYGGKLAPKDYKNPNAVVRKQLSPHKVALIIASDAEEATMDSKDYDHTKNMTLMFFLDRLMDKGQPRTLHDLSCQFGTKGFTKEMRQIAGGSQSGLRKFLQQYPFLFTIDGDQVSVTSFEGDSSGNSPQRDYVQEAIDYFRAKLEQYGNAEVPIKSLLGHRSQATPEIRHVSGQHGREFRDFLAKHSDVFVVKEEHVVLRSVLQNAAQGDAVIKVAEEAPLDSGLRDQLTSIFETFLRSRGGSASLDALYGHLTSRFSRDTYSRMMQSPQDLSAFLRMNTHRFQIQASVVTLIERTQPEPAATPSRGSIQQRLKSHILKAVADNSAMDHKMAGVNSAREQDQTLGDMLRGVRVITKVKECEALVLRLSSQHQLVALDTEGVNLGPQGPLTLVQLATPAAEVFLFDVQSAPQLFTEGHLRDILEAEHITKVMHDCRNDSAALFFQFGIKLQNVFDTQAAHATLQQQDVGKPVHKVKNVSLGTLCTLYGGPANPRRDQVKSLYRRDQKFWSRRPLSEDMIFHAAFDVFCLLPGVYGALQGALRPESEPLLWALCEEQALAHISPDEVKQRKKQRKLDHEVDDLRRRLDAARHTQRQVVLSNREIRLLRYVNLTEEECARIDGNPKVARKLDRLRNRGAGAAGTGATDGSPGIGDEDDEEDEDATESESESTDSDLPRSGDWSCDSLGAAVSPSHSTDCSGPKAPSPVTANGHTSRDGCCYCCCGEGRMPREGVDATCQTLSTGDIVITKVFFEEQEHGGKTIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDS9</accession>
    <name>A0A9D4QDS9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDS9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041283"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056215"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46655" checksum="7B665F361B4B7B9A" modified="2023-05-03" version="1">MFLAVGDRELHQQFQGTNVVRCFRYVDDYLVCVNQPIDASTVERVVKMFTEAHEGLQFTHEVPIESTLPYLDLNIRQEESHMCYMYRTRGEKCIRRFDSAHTKLVKRAIANACMLQAIKKSCAHGRSESFNLQVQRLQGSGYPDSVLVSNLAASVTSHPKVTIFLGLKLKEKGADLSTKKHLAVDVFRAAKDMKSLFKGGEAFIKKRSLYTLTCCRVTLLVLVTHNVENMGSTSCISTPISSWKASAYHDPTKPALEHMLKFLEFVLKEEKELEVALSSTLVFMGYTMKKAATKPVNFGGSCLGNHPQPFYGYCLTKLPDVEEHADSMTAVALDGTVLFSFETADSVTKKMRRFVLDLDDKVYRRVGWAFFDLAYEIYNTTFCAAGSAITSNYPRLYAAKAVLDENRNRKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEC5</accession>
    <name>A0A9D4QEC5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEC5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046074"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57574" checksum="814DF1CEB7E90A2E" modified="2023-05-03" version="1">MSALGQEVSDTLSKFMETTEIEASEDLESSAEVSAKLTLSYIAEIDEEQLMTSDDLTVTSDQVLKPASGDDATTCAVPKRDELRQTPEGIEESLDETSETTDEGAVKNNALFKKRFGVGSATSEYQCSESTYLADVDIDGDATSEDSRLEKKNLSASEAETPIDESNQIIAKVPAVSSEGRVRKRSRWGQRESEVTNITENQPMTSQQEAEVKRKTKELRTVLLNGRILKVIAEEEEDNQASGHNVNAIAPLPDGQFYNIAAVDPKEAPRAIYRKRDTDGVPVVFTSTVADVSFWDLNPNHFARELRAVAGDEILSHRMTNHGALVLYVNTGEMARELLKLTTVAGMPVTVHVPRSYSKNMGKIRTVPFHYTNANIVTILARIGVVKARRQCKNLRMSDGTNVRYTRSNVVLTFRDDVELPSHVKLGFLRFPVEPYVEPPMMCRNCQGYWHTARACYRPPHCRTCAGPHFYTECQSKDRPRCANCRGPHTAVHFRCPARQEAYKKKRYELAHFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEL1</accession>
    <name>A0A9D4QEL1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049083"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14530" checksum="44263FDC2D0CDD48" modified="2023-05-03" version="1">MATLADQIAASGDCSAVTTPFRRLAEFSPDTESIEVYTERFKVFANAKNIDESRKAQLKKLAATCEFGSFLEESLRDRLISGLRSKDIRCRLLSLPNKGATWERVLNIATAMETAKNDTKEILPAPDDVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF78</accession>
    <name>A0A9D4QF78_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF78"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028898"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="64" mass="6922" checksum="FAED5849678CB0E8" modified="2023-05-03" version="1">MAGPADDVIAQINESLKDAVKNETKFQPTPAGQAVAYTSIMLMAFFPIVLGAFKSVTHQRKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG11</accession>
    <name>A0A9D4QG11_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_003108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG11"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040501"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7982118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="579" mass="63501" checksum="BFA2A567217C2125" modified="2023-05-03" version="1">MMEGAAVVMEGDDLPPEDFGEEHGWRSAAVKKHSRRTDASATERATTCGDAGGYFNAIRKDLNLNKVIKSSRMPRLPSEHWKIIVRPRGGLDVQQTGSARLGRAIAVAAGIAPELAGQDVVCPNTMQNIIVISTASRANADSYLRMRCLTLGIKQYEINTYEAAPHATCKGVIRKIDISESQTDLEKSILTDRNPSALGVKRIKNSETVVIVFDGYKVPNFVYFGTALVRCSLYHRQHDCCYACGRLGHRADVCPTPDEVVCKQCGISNPGENHTCSPKCGLCGGPHATTDKSCKQRFQLPFIVRWRRRERRAESERRSQPSEPASADVGLTQHAEAQADDCDSSQRPRSPSRSSARSRSRSRGRKDGGSSEGRPRSRSKSRRRSKSRGRSLSRSRTGDPQGKVHFQGESEPALQGGTWADRVRSGGRPGGKVTGGTAPEQGLEELNQLRKENAEMRSIIESLRAEMAELRRTSKSQPTPSSASQLSGSPSPQPTEVPMVVEAGPSGNPAKRKAVSSSAENVQAKAKSEIKETLNSICLEIQRLNERLSVMDHRLTVMDQKIDAQNQFIVCMFYILATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG74</accession>
    <name>A0A9D4QG74_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG74"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045289"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7981913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="31776" checksum="C8A527A0C43D472B" modified="2023-05-03" version="1">MARLCPLQAVCRHCGRTHEEDSQCEETPFCVACQAAGHISLDPNCPTRAFRATSPPLPKKNAAAKSNQGEQPEPLDKNTGTPPKTWSQVTASNAGINNNNVEDRLERFEQAQAASTGAWNKFQQQMENFMQQKLDAMQQQITSWIQASQGIREQTAINSPSQVKPKKSDGPPLPKKPSPTAAEHTVQANPATQPRIEKHNELQRTPSTLDRKSSVTTDQALDTIMQLLEKLNSRMEAIERAMTQQEQVIMQHKEVNEREIAQIKATADECKRNYRRARNRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGQ0</accession>
    <name>A0A9D4QGQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_002178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGQ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031479"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="57"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7981952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="360" mass="37682" checksum="B0910B1A6E8EF6B4" modified="2023-05-03" version="1">MSVLCRRDGAGGLPDPMSTAPNGSVASWTRDEDPGSGQNAAVRLTLLSCVSAAGSLGGVFVISAVIVMEPLRTRGNAFLVSSALAHLLVSALLLPSTCVAILAGVTRDPGLCHFQWALLVVCLVASLLSFACLAASQGLALRCSRGAVLAAALASWIVATTVALGQRGLGLGPTFCGGAPMASNVPLQAAVAALCILVPVLLTVLGFGVALARMRRHEPDGAALELLKSHVAVYLLTLAMWVPGVALAAVSISREVPPHLVDVAWWLALSHSCLYSYVYAATHRTFRVAFNKLFFYCCCKSHVTFSRPSREQRIGPQGSGVGLRVHIIPAMNIYSAKKDSSQAAVKHCVQGKGLHCSYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIU8</accession>
    <name>A0A9D4QIU8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_008064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIU8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039413"/>
    <dbReference type="OMA" id="DHRATND"/>
    <dbReference type="OrthoDB" id="6509683at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058745">
        <property type="entry name" value="PWI_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26084">
        <property type="entry name" value="PWI_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7982897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="419" mass="46433" checksum="0CD91715C6F9AF55" modified="2023-05-03" version="1">MAAPPSRGDSPNDDPTADSSDSTQEPTDATTPELPSSHNASSPDDKCVICLELVENKASPDGCHHHFCFSCLVEWSKVKDSCPLCMQRFGSIIHNVRSQEDHDRYFIREQQSSSILSLIGSARTLSIPVEIISQLQLGRILRQEYEGQSRLPHATFPNALRGPHTSVERLHQYISDLWAVPNIPNSRHVSPEFYCANPRQVDHLVHWLNRDLNALMDHNETRVSDASNNVLSLILNLDNRHPDFSRRVQPLLNAYTEPFVQEFYSFASPVFETINEYDRSTIYAARHYAFAAANPVDCFRLVLRDSRRASAPIASTAPAAVTHDTPQPGPSVHAAPTVPAVTSSTGNGSNSHSSNCVVMTVRNPLRDRTPTMTISSQVTSYVRATRVADRVTQVAQSDDCRPLDHRATNDPSSSDESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNV0</accession>
    <name>A0A9D4SNV0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15/At3g58940/PEG3-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15/At3g58940/PEG3-like LRR" evidence="1">
        <location>
            <begin position="90"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="328" mass="36636" checksum="F2C91F3E8945EB8A" modified="2023-05-03" version="1">MPKRKTPKPLYRLCVVYVAGTIHSLCPTHDDDSAAVFPPHVSEDLVDALQSYKQSNFTSLHHLLTHRLRRIKLSFIDCHLPIDKPSRLPRLLRQIAAHGKQLVELSLVGAVHQDDATLVTALGRLPRLRRLTLCLCNVTDRVVISIAEHCHELTELKLSGQRVTDESLYLLVACEQLRSVLLESDMCFDPRITVSSSFHLLRGLPRLQTLKIPFLTEALLLFPAGCKLSLVEYVERSLSPLLQCTTALPHIVSICPLLTRVSLFLKGQEGILPLGLLKSLADLTLRVISNSSELFFRRQVEPVLKMVGPHLKTLTLSLPDLDVAAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP55</accession>
    <name>A0A9D4SP55_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerophosphodiester phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_013168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035237"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13653">
        <property type="entry name" value="GDPD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7939489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26535" checksum="FAC0C772D5DAB415" modified="2023-05-03" version="1">MPPPRAHAKRPFYIIGHMVNSVEEVDKFLRQGSNALEVDIEFAENGDSRFRGQMSLLFLDLKTTKLSKSAKPVAGVTLAYNLVKHLWKGGFDVGMNDPLDNIARMYKKLHINGHRWQGDGLSNCLRFLMPVDRLKAAVKLRDSKRGYIDKVYHWTIDLPFYIEKSIRLGVDGIITNQPHNVLGVVTSIFFQKRLKVASMKDSPWQKIRRTPQEVLEDEGDTDTNMVGGGDAGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ41</accession>
    <name>A0A9D4SQ41_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056582"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="291" mass="32582" checksum="2702F5EBC77ACD2A" modified="2023-05-03" version="1">MQSVLLVTATLILPVHLLCLRVPLLKEVAGFLGSWILTLVASYWLACFLWNRTLKRSVEPKGKAVLVTGCDTGFGHHAAKRFADDGFTVFAGCLNATCDGAKDLAKRSNVRVLQLDITKEEQVEKALETVTANLGSNGRVTIPGVTVYCMSKHAMLSLVDGLRRECEEEGVDVAAVEPTAYRTNMLENIACPKFVEADLKLLPDEARKLIPEDSVDRWAKFLRGMFDLLTRENPMEVVDQMSFAVKDVRPRPCYRAMTLPDKFYLLFVKLFPDEVLDVFFTVFRAVAQFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSR4</accession>
    <name>A0A9D4SSR4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_015616</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSR4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033251"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7947761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="29453" checksum="DBEF6CC7B0BD9D05" modified="2023-05-03" version="1">MSFKRDDDVPSLRFLRVKKDIADIASDPPPGIYVAPEENDISRIYALVVGPSGTPYEGGFLLFHLVCSFEYPIKPPRVRFLTTDAGRVALHPYLYMSGEVSLSILGTFSGPQWSPAQSLWSLLVSIQSLLTHDPFYDRVYYYVEDDKETERKVADDYKVYIRHEVIRVAVCGAVESCLESGSSYPAEFRGTVLKLFLEHYDSYEESVKSHLRVKGEEINYPDVFPRKMSHYEALLARLRDLKAKVEKRVESAVPADANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST22</accession>
    <name>A0A9D4ST22_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056463"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13290" checksum="E50D59022B30DEDF" modified="2023-05-03" version="1">MDRIKGKRATQRALHTRLRNEASQLIQSSQFSAPALRVLHDRLKNCNDGLRVLNEQLEEHLTDEQAAEDYLSVSEYEDTAAATLSLLSYHIEQLQPETTADRGLTMRSDVATPGIKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST28</accession>
    <name>A0A9D4ST28_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST28"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32667" checksum="96AE1BA4F9EF1B0D" modified="2023-05-03" version="1">MAYYVTPSIFRTSNNSEGSWNGTAAYWVKSLDNHLSSLQPLSPSDDVLIANTELLEAMRRFIEDRGDKEAITHISWQLVQMYSVMLDKTLLEAILENKPRSSSLHALLCARQVDTIDNPLLTALYVRSRLTPTARTQVNALFLTLMQAAVAEVNQLPWLDLEGRQFFAGRLESTVVHLWPPDVFDDNGKVHEIYLRCPRSETSFMRLWVAERQCLSGLLTGKHREYVSLAVPNFTPYLSAYDSFEPAAELAMAALADARNARNALRRSGLLVRSYISARNEWKKAARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST79</accession>
    <name>A0A9D4ST79_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_018791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST79"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027838"/>
    <dbReference type="OMA" id="CGAETTE"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="527" mass="59904" checksum="6549D527A810BA11" modified="2023-05-03" version="1">MLLTSFPVVFCDKAPPDIVFFFADDMGWDDPSFHGSSQIPTPNLDALAADGVILNNFYVLPACTPSRSAFMTGRYPIRMGTQGYPVDIGQPWGLPLDIRILPEYLRDLGYETHLVGKWHLGSYMKSLTPPQRGFDSFYGFYYGEEDYYSHNATFENHTGLDFWFNDEPRWRDSGKYSTTLFTERAQEIIRNRRKPLFLYVAYQAPHGSGGVDPLQAPARNVMKFPYIGEEKRTLFAGMIDTVDESVGKVFETLQEAGMLDNSVILFSSDNGGTPFGDHSSRSFNWPLRGLKMSVWEGSTRVPAFVWSPLLKEKQRVSNQLMHLTDWFTTFYRLAGGDVSSLENVDGLDMWDYLSNGTGSPRTELLYNIDPLDPEESSVAAIRNSQYKLVLDASAADNERYRTTGGRRPFNDVDELLARSRAAEALRKFYNTDRLEFPSDWRQRARLTCGEDATENFSPDDKVFLFDIEKDPCELNNLAADHPEIVSALKKRLDYYRSVATPALSKPRDPLSFPENHNGTWAPWMPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST85</accession>
    <name>A0A9D4ST85_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST85"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027422"/>
    <dbReference type="OMA" id="NGDHNTQ"/>
    <dbReference type="OrthoDB" id="10257479at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037354">
        <property type="entry name" value="Commd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="23100" checksum="BF843F0E7F54917A" modified="2023-05-03" version="1">MLLLLDDDHKQHLQFITTVDEPVAKEFCKIANEFLIRGVNTKVYHSAAQKLQVDHEVVQGAVEGLSHLLSQAAKLKLTEQHFRESLLLLSFPESVCEELVRYHAENEKNVRKLLSEKSIPRWSFSHLQWRLEAEIATRCLKSHVTPLVTFKFHLKQGDGSETKEVVLQTDPLNLLHITESLEEALQSAKSLHMRRIAKHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STB7</accession>
    <name>A0A9D4STB7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_020354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056602"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="160" mass="18795" checksum="FAFE5F61AD67E5C5" modified="2023-05-03" version="1">MSSTLRPYLTAVRHTLNAAMCLENFSSQVVERHNKPEVEVRSSKELLLTPVVISRNEKEKVLIEGSINSLRISIAIKQADDIEHILCHKFMRFMMMRAENFIGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSLNARARICAEEFLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STE5</accession>
    <name>A0A9D4STE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STE5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20106" checksum="697DD7A802ACAA7A" modified="2023-05-03" version="1">MVKSTNILVNLTDPKLLRWIFYSGIQLHRLPFRNMMALDCRLVGHRTDVYPKQRPEQSHRCGVTDTPSLGGSPPICSPRCIVSVGHAQYRLHSCRHSSTYKHLYVRHPQLSKAPVPHTHPSPRQPVATPAPVRCPRQAARGPSPPPPCKSVTAFPPLVPVMPKPASQPTHLTGFRSTTGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STJ7</accession>
    <name>A0A9D4STJ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STJ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69994" checksum="E0FB53E2E116C89F" modified="2023-05-03" version="1">MDNSEEGSLLFPAAIRLRRSSEAPQHRDWSPPSPWSPPPARWPRRLSHGSESTSRGTPEDESYVANSGSSPILYPTSRKLSDEPSKLYNDVRATRRRLVSLPSRPLATGDAVRERSPASHGRSTPSQRLHRPRAQSIELDDRQNDTLRRAAQRHTARGRFLDIDDDMTCSRIPSPVNPDSEYASHARVQRRLHSRRVTSVPPRVRVVVASKNGTPTLSPSPPIDEFTDIPPVDLILFEPPKSLTAGVQQSSQSLPLEAPRPRGILQVSKQKPVEKDEIHSESPNAMTAALETSLRPSGLEEAPASPAEPATNDRMTCLKIWVLCVATATTLSLPLGMFILSYLLTPLRDISNLTTTGTSGTTTKPGPTTSSVTARTALPTYTFTIPQNRQTVDPWNGVAQSCQIVPMVAGGQVKPLTTHTLAPSRGTGIFCLYNNTRFYRGGNYDFLPQNIPFALCRNIVYWSFGVRDGIPISRSENFDRTYGLDKLSELANRSNVPDIRILLTMGGFLEDYAQLSLLGRDSGALSRFVQRTIALMKLHFLHGIVIHWIVGEPTCKHSAVDDVLPDETTLMNAFNAIPPANPSQHCTLLVDLDLDNYAKQGARVLWLYWLTRYVHEALNSTAASYLSRSMSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUT6</accession>
    <name>A0A9D4SUT6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUT6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038785"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047601"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34228" checksum="B38F9AA052D9FE2B" modified="2023-05-03" version="1">MGMTWMLGFITAFFNVLAMDIVVIILIGLQGVYLFFGFRDYHHLIPKRFRKRRNVRTDDTDCNATLPWNVSQVDHPAILQDRLDELLRCPDGLHGCSASPANCEDGLHAVMCSCAANCALYGNCCWQAEVSLSPARRSSVPVSGPYDEVRDSCENATDLSDGFYSIPVTTERGLTYSNAFCALCNYDLDSTSIFWNASGTGKMGLQVTPPLYVSQNKDFFLWPCDSRLVDIQTCPEGSDLETKRRCSTYFAPVELEGSEFEVVYKNVYCGLCNGIHPSSMKCIPKHFVPELWIRTLKKKASSRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW15</accession>
    <name>A0A9D4SW15_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048711"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="51360" checksum="D998AF0A62480BA5" modified="2023-05-03" version="1">MLPNMNPLINVGDFAAPGDGERGGGTADVGADAADDGEPTELRLHWNVILIAVLMDFGQSAAFRSSGFIYVALQDHFQVDHEAASWPVSVLGTVVDAGGILAGPLCQWFGAAVTLRAGALVTALGVMASAFVPDIPWMTVTLGVIHGAGAGTVSMMLQVFLSMTFVKYRGTAHGIMFMGSILASLTIPQALFFLENTYGFSGCLLVFGALLLHLVPISFLLRSSSSRSSSLQPDTGPTALVETRDVNLNIKEDLESESKSCSSSSSAKGKPGVLQSAAEVLRLPMFYVILVTWTVMCYNEDIFLTTIVDFAVDKGIAKNMAVPLLSYLSFTDAIGRIGLPLLADRNIIRRSTLVCCNAALTAASVAILPEANAYAFLVVATLFAACFNGCGMTMHGVLMADYIGMDNLPVGYGVAGILVVPLLLVKPVLIVPRTLSAQLTLSTGAGVVDLDLVGARLRLVLLRDRDRLRDRDLDLGLVISVGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWM5</accession>
    <name>A0A9D4SWM5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWM5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038626420" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10464" checksum="0C4E0AF046499DFC" modified="2023-05-03" version="1">MPSPIISCVLLVPSAGADTVQQKQKEQSPPPHKYNLPSKFIEALQPIYQRLSDPQLLARGDHIFKDRDHILQPYAKWGLKDTNYQMDWSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXE8</accession>
    <name>A0A9D4SXE8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031400"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7955624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21300" checksum="6455958B0A59E6F7" modified="2023-05-03" version="1">MLPEPGVATKEGELVREGDAYNTVLRGHIGSHTFVISAEVKAVDPSIQCEAGSTGSYVEFKTNRVFSTEGQRSKFTKHKLLNWWAQSRLAGVPKGLCGFRDDNGIVMRVQEFDVNRMPDKAKGLWSEDVCMRFLNNVLAFIKQHVQGDDGRPVYLLKYEPSNREITCKRLADPGKLYSLPYWFLAGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZC1</accession>
    <name>A0A9D4SZC1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_024040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZC1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048185"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31616" checksum="040091FA977B4926" modified="2023-05-03" version="1">MSQMHMTAKIYYTISIADSSSHVFARLEVCVSISGTLTALTVVLAQHFEKRRATAYSVVFTVSALNTFVFPPLVELFLYTYGLYGTFLLLGAICLNTFPAAIAIASPVKPQARSGSGTPEEAVALRDDCEQRDPLREALKCFATPRFWVDAMSFGVMYLALSLYLTLAVDLANDKGVDTTRAVFLLHAFSAGDVVFRGVSGFVLDSGALSSDGVMLLGFVLQASALEVLACSASFPMLVVGSLVLGSGNGLRMPIAGVVLIGDFGLKLLPMVFGGFALVCGLNVWVRAPLIGNSMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZE6</accession>
    <name>A0A9D4SZE6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZE6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="349" mass="38281" checksum="2C250B902058B753" modified="2023-05-03" version="1">MSKVVIGAGWTTALSKRKSTKESLPAAGVPVTGRPYGKNVGFQPLANVKKRLANASRLPRLPREHFRVIVRLQGGLNVKNTSNLRITQALTTAAGHDVSSYFAAPDNTCKGIIRNIDMEFNHEELRRLIIQPRNPNVLDVRRIKNSTMVVILFEGLSPKLRHVWSQHDQVHPLTKADGRLLCLWSTRPQSRRVPYSGECDLAGFAESAPLATSTFARQSAPSVEGLNPRPTEAVGRPNRQTSPGLEAHPEAPMEMRPGAVAGPKAVLGPEACCHGDRVGRPCQGILDKEQNNDRIIQLERENAALKAAIEQLRAEMAELRKEANTAKSEVPQPPQVTSVETPMEPKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1S0</accession>
    <name>A0A9D4T1S0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1S0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051851"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034783">
        <property type="entry name" value="SNX4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596:SF1">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17147" checksum="6D814BFA30BF1A0A" modified="2023-05-03" version="1">MVAPSQAASGVASQGLMSRLLHSSSTPEHKTQALEQQLHSLDTEIQAMTREKQEFSEKALAEITKFREQKERDFTRALTIFVSTNIRLCRESIAIWERVCQCFEEICQLEDEAAPIGGNANLPAVNKASPVINTLPTSVEDVCREQSTRNSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T278</accession>
    <name>A0A9D4T278_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_022325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T278"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040716"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="153"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7963657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="249" mass="28325" checksum="5A6F19E7F1386E83" modified="2023-05-03" version="1">MPIRVIQCYGNPIQLVCCGASFLGAAVWQYERMRHEARAIISQRWTWEPKRGSWRQQLNAWWHSIPEGNRVAYGLIAANAVVFLLWRVPRMEPIMLRYFVSHPASKPLCLPMFLSTFSHHSFIHLAANMVVLNSFVPTAVALLGREQFLAMYSGAILAVVGALCVQYPDAQLSILFLPFFTFSAAAALKGVLAFDTAGMLFRWHLLDHAAHLGGTLFGVGYVLYGQEIWKRREPILNTWHQLREGWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2Y4</accession>
    <name>A0A9D4T2Y4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2Y4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030092"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15332" checksum="0F96FF2496A46AAA" modified="2023-05-03" version="1">MRATESWCRLQAVFTRNKVTQTVGAVLLSAGLVALLRPELEVSRALLDDDSGRPPAEVAGFYIVSGCMLLLIATLGCGGSCGERYGWMVVVCTKNFDVNNRRHWSILVQSLAVFVLLVTLTLATTVCCKARARRGYLAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T492</accession>
    <name>A0A9D4T492_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T492"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036875"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7969542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="236" mass="26891" checksum="DC4652208CF247EB" modified="2023-05-03" version="1">MPSMHSYTVAKKIEVVQWHRQAGRNAHTTSRHFNIDRRRIREWDNKYVALLQQNFGKSKSRRKLSNGATVLSEEVDDALFEFFQSERSAGRAVSNRLLAEEAVRIARSLQLRNFVASDHYIARWKKCFGISMRQATNESQKTPDDYAEAARAFRLSDVLNFVAAAWDAVPEETTIQRFKGCGISNVLDGSEDGLLHGQLSDVGDIRPEHPEELQAEWYSLLFDTDSDGSFDGFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T495</accession>
    <name>A0A9D4T495_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T495"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="516" mass="57194" checksum="AFE4F98BBCB6B6FD" modified="2023-05-03" version="1">MGNEQIAATDSAMPGRVEEIACDVLWPCTRSPTQVCQVLSNLATHNRVLWHLGLHLREDPRDNVGELSVVQAPGFNAEPHHSASDERAESFAIAVLRRLFEEHRCIVAAEVNHVVAKTDSLLGSLAAAPCLRRLTVAKIQDCEPILEIDSWVMTTFNITGKRAIRSHSDTSSIGAALNAVGILLQRTDNVLKTLDIAALEITGHALRRRIILALCKNRTIAELAVPYSVIACDSIAPRNSAKPFALYLARADATLRKLAIGSCSSCTATTLRLGSLIPAIWRMSTLEELNIVVHFNMREYEQFADVVANSQSLRSFAVRCCRDLQVSLLLAPFHEADPRRLEAEAAIVEALSAIHHVTKLTLTTGPLREQHYRRLADRVLENLGLRELSVTVMNDSFCDVFLDRLLPGLRYNYNIVRLQLEHSGGTFSDAMATAQNIVRRNCSIERRAVQFVMGVHDPYCARVVEIAAERLGFVEAVRREAVVTKTEAAEKLKEALSIVRLADVPRIHECTGWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T566</accession>
    <name>A0A9D4T566_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_005934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T566"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052324"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="329" mass="38191" checksum="B44C2A762E393EBC" modified="2023-05-03" version="1">MKTRVARSQDEKNQRPNVYHVIDGLHLSRLFTERSIRSVMAYRPRDDDVFVVSYPKCGSTWLQQVVNAVLKTDESSREPAQAGRQELPLFLDFVGAEGARSMPRPACLKTHLPYGMHPYSPEAKYIYITRNPYDCCVSFYYHTRRLPTYRFQEGTFDQFFDLFVQGKVDYGDYFDHLLSWYAHRDDPNLLFITYEELKKGTAGWVQKIADFLGKEQYGDRMQQHPELLEHVLASTSVGNMKSLNSKLKNWTAVVESVPAEAREELTKSLKDTFGDIWDVPTKADFIRKGLVGDWKIHFSPKQIRIMKDRIESKTRGSDVMELWKDVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5D1</accession>
    <name>A0A9D4T5D1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_010054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5D1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="468" mass="50839" checksum="8C59637C329786E4" modified="2023-05-03" version="1">MGEIKHGEPERQLSGFGGTLEWRPLVFVESVPYVYSCTLCGVIAAFPKRITRCCHVFCPLCFERFVDGQRLCPLDQIPFADGMIETLDSGHGGVNQLQARCPNATHGCTFVAHLAQLEDHFLHHCKQKNVQCPRCGLDIIQRTALSHFFQDCSGVRKVVSANEDGRAYWDVSCSSVLNRKSLSADSVVSSSATKDYKDEARKSSSADTARDKTFATAGIRKPSQQKREASDRSSSSSNSALPSAQSSIIKTSHGTAASTKQDRHDETRNANPSKIAKGVRKTHSSLSEKKLLEKVESMITRAAENASDAASSAETSVSPETTSSGVMSTSITQVHHNKTLSTEFVSSPSAKNMKHLRKVKVRDTMDKQDADEKAVAAVSPTGFVFCYITGLVGSDTRLACGEELFLRSDSSKFAGCGTSCGHTGTNCYCRRCHHSGSSYYDGGVDPTAQQRYPLRKKYSDAAKGNSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6C9</accession>
    <name>A0A9D4T6C9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6C9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038384211" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14342" checksum="94E32A2006FBAC9E" modified="2023-05-03" version="1">MAGMRLVNPFIYLVQLFAALSTSSAVHNGSGARTHPASTKLIDDIDWHEAKVPFNAVIPTLPRMRLPSPITSENDHGATTMTQWTHKAIRMAHDPRTAHGHGSMAGMSLVNPFIYLVQVRKSYGKCFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T780</accession>
    <name>A0A9D4T780_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T780"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="30547" checksum="34BE3005F0D172B8" modified="2023-05-03" version="1">MEVVVNGTDVSPKELDQPGWMEAHKALGRGRTTKKAAAGAFMDASATSKQTDASQTASQTASQKSIVEKSGASKPGEPRRPRRRAPPPQMPANDYKIFVRPRDGLNLSVCSEAEIADCIRKTLRFPDTTTITDVVQVNRAQNLVLISTPAAKDEQRPTVACQRFCSMANPTRSVVRTILCRKTSVNRSAWCVEARTWRVRKTVGNVSRRHLLSGGDGSNNECHSPLKSQPRTKKDTPRDLAVPRDESDKSRGLLGAGASPSRRCRPSRGPNPDPGIIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7Y7</accession>
    <name>A0A9D4T7Y7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7Y7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="385" mass="42188" checksum="CB75FAC8965E45A9" modified="2023-05-03" version="1">MSSPYHQRQVPETDLKSAGTASSEGEDDDWEEHHEWTYTELDDDDDDESGERKLANSGYHHYAGGLMGTAEGVTTSRNEGRRIAFNKGKSREALTANQQSDSKSSQQRKESAYATNNKSTKLFKSRAPNSTVNSTKAKFVRAGGGQFRGQALHICDRLEDYARTNPDNLYWGFPTVSVRTMPVAVRVPEASTDAITPVLPIAYESAEAFTQRVFTEPLALYPDAAVNYHETHTDFLEPVVFLANHVDRDVEYVDEDVVAPVYAEDMAVPVMEGHEAPVLEDAAETTAETAANDDMPTVIEMKDSVEYVPPVSENVHTDFIAAPDVAVDANAPAEDVYDGADEKTDNIAYDAVLGVDDADPGYYQEVAEPVVHVTVQTLSFPAPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9W9</accession>
    <name>A0A9D4T9W9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9W9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28402" checksum="0A73078AA10A9987" modified="2023-05-03" version="1">MEIVVLRRRRRKKAKTLSVRLKQRGSKPSNRRRRRSGNHRPKRRRGSGDGQGVTTASGAFTSVVPLPVILCVMDTRFAHLNPDRRSPAMRRNPQVVVAPEGQGNERFGDLTPERRLEELRAEVEKLSQVIGGGARDSELASVRQDRCGELRRYSKVLTGVLPKFPTEAEAPVWFESVESALEAYERNLSEEALRYVTLQEGRQWVNAPELAASLRTFEEAQGMNSAAKQKVLESQSASISKLDTQPSSRGGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAB1</accession>
    <name>A0A9D4TAB1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAB1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="450" mass="48256" checksum="9EF32E5AEBFB9E01" modified="2023-05-03" version="1">MGRDVPSGTGIKRKFDDTAAACSGELPACKSLSSMFLVANSLDTSDDVSYVSSALAIEEGLPDDRSSVNMQWKKASGRVSGAGHRGMFQRAARDLLLDTGAKDTACHCNAVHQTRTFQETRHQPVSLSRGTGRPYIPSAKKPRTRPLEVGMSTNLEVVEGGAADSADSLGDLARDPRIHVLCTLARLLAEAGYPKQLHLEATCAQGEVDALDIIAEYNGIDPIPSMGRDVPIRTGIKSNLDDKAAGFSVESAARKPPSSMFLVASSLENSDGVSCVSSALAIEDSLPDNRSFVNVLRKKADGRVSGPGHRGMCQTAERDFLFETGTKDTACRCHVVHRPRTLQEARRQPVALSRGTERPCIRSAMKPSTRPLEVGMSTSLEVVAVGAGNSADSLGDLARDARIRLLYTLSCGSTKAGYPKQLRLEATCAEESQYPDGLDLGYYFSVDYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCI6</accession>
    <name>A0A9D4TCI6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_024340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001108">
        <property type="protein sequence ID" value="KAH7985054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCI6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033757"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052865"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="265"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7985054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="571" mass="62386" checksum="30BEE998877043E5" modified="2023-05-03" version="1">MQQEPVRDRPVKKKKIRAWTEAARIVLELHPQTPMSHKEIFSEICTRGLKDASSPAALACLNAMLHAHSRGPEALFYRVFGAASVFGLKTDIPGSAVSLEADEDSGPETEDASVVNCVRDHKKAKVLYVKLPAGFRTPKGLSMDIMANGESLPNQQPIPNGICSSVPLDREPLRHSVRQQRRPVCYTDDSIERRTLASAVQASRSSARVAAKCNAQLVANDRPQTTREILASLPGVKPHKRSSRKLSMTAQIAETRRGLVDLETPDSILVNTNIKDLLTRHTMASLPTSYQCRLASLLPAVDCWQDAGTVRLSSSALSNEFFARACQEWRERLADGELTHESQVRLRAEQDRASLDPWKGRHFEHVWGHRAANVGSLSCARSCPRESRTGTLCMGTELKVDLLGAIQMMTGAWQDVKTDTVANRFRKAGFVTAELAETSEDFDDERTDDAFRELSSLIMAAVPPEVEADCNVQAVASLADENIVAAVAGTQDAQADSSSGDEDCPDEAAATRAYSAAEVAAAFGLIRRCCGDKEGTGLSHLDSLDKIEASVFNFISKTKKQAKISDFLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCQ4</accession>
    <name>A0A9D4TCQ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000988">
        <property type="protein sequence ID" value="KAH7985331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCQ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041049"/>
    <dbReference type="OrthoDB" id="10057083at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32878" checksum="6F9454BE89A4EE2D" modified="2023-05-03" version="1">MSVPGLAPPPFFLATPGRPPLRWEQWEQMFNVYLVASGAAEFTPARRKAILLHCLGPEGQRIYQTLPAGSTAAAPPVPSAAALAVKDGDKSAAATSDKYDTALVALRHHFSTSCNVVVERHRFHRRRQHSGESVHDFVAALRELASHCSFVSQDDALRDQIVAGIASNRVRERLLLEGPSLSFEGSVRIALQFEQAAEELKEFSPSVDKVSMQRRRKKPLHSSQKSNSEPAAHFQQKLTKSASGSRAPQGHRPPERNREHSRRSASPHCFRCGSRDHFASDMQYASRWRIRYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDE5</accession>
    <name>A0A9D4TDE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000562">
        <property type="protein sequence ID" value="KAH7986166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055481"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="143" mass="15608" checksum="D68CA5BF3F0E6909" modified="2023-05-03" version="1">MERAKNKRASRRAMNTKIINEVNQVLQSNQFELSGLRILHGCLRASNLELKALNNEVESLMTDDLAADDYEVVVQYDDAANSTLALLEHRIDVLKTSATPASSSPSASGAGSHETAPSGHGRLPQREFGARLPKLELLRLMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDG7</accession>
    <name>A0A9D4TDG7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_025080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000505">
        <property type="protein sequence ID" value="KAH7986285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDG7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="561"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7986285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="710" mass="80169" checksum="5688F552E0555BDB" modified="2023-05-03" version="1">MILLCSPSSMVRDRAAGAGGVAASSGGVRPLKAALMAIFSLSLALAIALVVVFTRQKHPQAQVHGEFQAAHLFSWQRQRSGFIYTCTSEHCLKEGEQLQKHVAWTLDPCEDFYDYVCSSTKPASSVRRSAVRHFLREIHDVIDKYSRLGWLKRTRLTNQVSSFYKACKNGHYNSVPEQMEQTLEFLKLSGKDAILEEGLASLAKILQVFPLVHVSVTNKAKNSRECIVLRRPKSFDGDHIFDIPKAFSKKYVPFVKALIGSEQAAHNVREVDIFLKKFSGLWSESYQKMSEYEATTIDDLKANGLNWRTFLFKLIESARKDHCVVIRSPDYFKHLDKMLQKFTTAQVGDFVKYSAILHLYPFVKLQQSASSTSYQNTSREVCSLLTYRVFNYVFVRHFNSTVRLDVITSAGMKEAILRNSYRSVLDSASEIPMTTVNSIEDEIMSIGPAYFSLMDDVDAYYSVNSFDPDVKNMLLSYVKAKAALSEHYVAAVLKSGETVLDGNLELTSQYDPDTSVLTVPLSIAPLVLKGREFFLESSTVGFVMTRFLYHVFQEKFLFSADAETEALQGVKSCLEKQYGAIEVGPLNKTLDGQRTLRENMADNVAVTVLHRAYRTSLLFYISTMDALGFQNVFLHFENLPSVSSEQLFYLMFGQSFCDPDEDTERVIDDATWAPAKYRVNVPLSNYEPFSKAFECQPGSKMNPKKKCRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQV2</accession>
    <name>A0A9D4YQV2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQV2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055656"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="257" mass="28612" checksum="D4D0D5E155C63843" modified="2023-05-03" version="1">MAQVLNLLFSKALSSEELLEWLTDPKYKATVVELQSLESERKNFIQVFIDFIRDQCPFIQQTPSPTKVRRPISPSARVSSCDSVLALKHDSAVCVRSRPPAVGRRQTTVRVAGECNKPLTLPTTAAQPDSSSVSRAEISSSELSTPCIIDRRPVSKGEQTQPAVSVFHNAPDIGDRTIFPAVNAVVENQRPIRRITPTPVKSHWRKLTLSDFLPPEVSHECQRKDSHRSPRQPHKDVVVESFGPNRNVAIPALPCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YS79</accession>
    <name>A0A9D4YS79_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000015">
        <property type="protein sequence ID" value="KAH7987860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YS79"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7987860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="10875" checksum="31FB77F57A26AE70" modified="2023-05-03" version="1">MKPSGFPSTSSPRSRNDEGNDVMLNDISGMPVLQEKHSAAAPAHASAWSIPALLIAAGILVIVLAIVTALYRCRRRYRNSADDSEMKPLSKYADGDAGETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB34</accession>
    <name>A0A9D4PB34_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001386">
        <property type="protein sequence ID" value="KAH7932518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB34"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21214" checksum="5A07B216F030B4DF" modified="2023-05-03" version="1">MEVEQVEGEDISANEIQEEQGWKTIHARNKKNRASDADIKPERQGDARSADADDLKRRASRNIQRMNAAPKKPHLPKEDIKVIIRPKDGFNTAGYSVAQIGDCILRATGLKPEEVLKDSIRINERQNIVVVSTPVLERADKYCAMKDFRMGDRTYEVTAYMTAPEDTSKGIIRGIPDYDTPEDIERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBJ4</accession>
    <name>A0A9D4PBJ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_004805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049784"/>
    <dbReference type="OMA" id="TMNCRSE"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="219" mass="25361" checksum="E04B5946B01AE369" modified="2023-05-03" version="1">MNARSEVFELCLEGRQVQEAVSGIFHTLLFHRTQGKFQYKTRGRYSVGTVGFEDVTCDFIDFTYVRCASDELNEAVCRDVTAFSDRLRSHDGPRTGQIWLEFFQKKRTHWILSSENIPWEVWNIRVNVITLPNEQERQRQRAQLGEQLAEKVIAVAASINRHQYLPRVPSEPDVELVFDTRFSDVQPYHFKVGYHTSGPSNNPSMGSTMRKLLKDTLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBQ2</accession>
    <name>A0A9D4PBQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_000477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049592"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7934780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="24458" checksum="7625500080D0FF4F" modified="2023-05-03" version="1">MAAPFFSNSAAARDAFPLSAAWGRARHCWPGSVREVMPRCFVTGCKSGYDSARVAAEKRHFFKPPNDASRLQEWQHAIPRSDRELTSSCVVCDLHFQEEDIVKNFVHKIGGDVVVIPRDKWSLKDDALPRFSPDSLDVWFAGGTFHLPENHPSVYTHHAAAALSLGVLAGRCAYDCAGRALARPGRRPGYFAGRSDRRVWLAHCSIPPPNTRHGQLDPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBW4</accession>
    <name>A0A9D4PBW4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBW4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="10944" checksum="C2AFF4BF15C5C05D" modified="2023-05-03" version="1">MGILYSGRDPLRQRKIPTKKNRWTELPPMSMARVGASVVGVNGRLHVMGGRRPSGYDRPFAIGGPPLTLESAETYDPEVSMWSKATPMPLSRCYAAAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PC04</accession>
    <name>A0A9D4PC04_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_008406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PC04"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033953"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RFX1-4/6/8-like BCD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57053" checksum="9434506063483A21" modified="2023-05-03" version="1">MPEEGGTGLLRWAWPEPVHAERGVGMAHENAGGREAGQVRVGMAASPLDTRHAALVGSARGPQGPWAHAAAVLSQATAELRGGRGRVHPQEHAVPALRGLLRSQLHAASERSQLRKGTCFSADGGSARNAALLAQIIRQQFPQLTTRRLGTRGQSRYHYYGIAVRVGSLYFEPPYAKGADAGHRRQPPQCPPSRLLLPEFPRVRELMLPAGADADQLAGFVAMYRGHCQRLLDECAQEPPGMLQCVAHFWRRVPAHLAPLLASNALANLVGICDGLLYGAVADALIPAYPPPPHDSNVCRAARLLSEQLEPWLDAALAGFPAPLRAIKLHSKHSGALMCKERCVNAVPTAVCRRLSQALGRRLSLAKLWPAWRAVVPDCALLDLAAVSTEAAARSPRPGTPSARFVYARAHELCALLGSDEQALFGWLEALVERSVASPSAASAACAAGPMARHFLAVWCAAGAEAERQLPALRPLRALLDEWTRVLLERLLGDALLRQLLDNVANDAPPDAWYWPRGLASLNLTVLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCS4</accession>
    <name>A0A9D4PCS4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCS4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="599" mass="65352" checksum="6DFA4B14016468DE" modified="2023-05-03" version="1">MRICSEPGLRKQELAVSLADVDKLRLLYDKVQFRVSALTGLGVSPDQYNVVLNRVLMRCLPDDLAILYRQKSKEAAQDTSGIATPEERAHVEPPSAPTGHLPTASALAAESVPITAAYAAVVSIPSRTATFNSQLRKNGLGCAPLVAATVAAGKTTSRVFADVRAASSVVSATDDISLSSVNCSRRQPQLVQTQRQHEHAVSDIGPKRPERNERRSSPNRTSLDRVRVSKANLTAMETKFGWTIQGTTERERSSAFPRCDRGGPPSQRRPFFRGCALQTARPPKYPRVLQGGSGGGFDGARGPRRGFGVRPPFHGNNDTSSRDYDHTRYGDCRGDAVDGPHSLPDRTQQGRPQWRQRGRSVTPPTQPSAWKENWRTRTSQGARSSTDRRGCWESRSFYYGSGSSDSETDRGRRHPSGESGRETMMATSSSRARSRNVAAENSHRVAVRIAGESRELTRGAKAASRIASRARMECPREEDCCSKRPGDPQPLGARSHHDQTNEVSVKTSVRKVTDSVEPAAVVTSKATSLGAQAKGQTMDAARTPKCPRHTIKRPVQKVIHSGGKSARFNCLVIALAPWELQSRLLIENGGPVWRRASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDZ6</accession>
    <name>A0A9D4PDZ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037826"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="217" mass="24622" checksum="284721EA7B455677" modified="2023-05-03" version="1">MSTKISRDTLYDCVNAVLQESARKHRKFLETVELQIALKNYDPQKDKRFSGTVKLKHIPRPKFQVCVLGDQQHCDEAKANNLACMDTEALKKLNKSKKLVKKLAKKYDAFMASESLIKQIPRLLGPGLNKAGKFPTLLTHNESMMAKLDEVKATIKFQMKKVLCLAVAVGNVKMTPDELAQNINLAINYLVSLLKKNWQNIRSLHIKSTMGPPQRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEU7</accession>
    <name>A0A9D4PEU7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_005239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEU7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034519"/>
    <dbReference type="OMA" id="CDYCRRV"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20516">
        <property type="entry name" value="CYCLIN_CCND_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000003">
        <property type="entry name" value="G1/S-specific cyclin-D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="163"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7939063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34785" checksum="AF92ACD3E3387909" modified="2023-05-03" version="1">MIEDGVLDLMCMETPHMGQVLRAPHDSAIVGDAAVMARLLGLQDRYAVTCDYCRRVQTEVQTPMRKTLALWMSEVCEEQGCEDSVFPTAMNLLDRYLSQVSVRKLHLQLLGCVCLLLASKMRQTRALAVEALVYYTDCSVTAQEIQAWELEVLNRLKWDVASVVANDFVDHLVAMLGLADCRDTVRRHANTFISLCATEYHFISYRPALLAASSVATAVHGLRTPLQTPGSQDELISSLGSIANVRTTEIRRCVLEIETLMATSVAAFQQQQCYSKSAAVTPYPSCKSNSLVTPCIADTPSSKPNTPTDVQDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFH8</accession>
    <name>A0A9D4PFH8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFH8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049772"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="461"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="658" mass="72952" checksum="A17C82BB3D5CC9C4" modified="2023-05-03" version="1">MAVLNFKVVIGLGILYGVIWSLVDQLAPACVPLLRPPEEVLQLCGGACCQRGHQDQPLRQHQARAVASKSPCACGPQERLRLPDRMDVYDEGREDTKIVLDIFKKYNFEWPSMSLPANFDLLEYLLGMSLEYGFATPAVLGLTPDLKTDKRYGLSLEIQIATDAGRNKTAGTDYVEQCITHVAPSVTIDLASAFAERIQNTAANMVTAAYAIFLGQRVSLNYTTIEKLANDVAGHGTVDAWLKVINGHMLPGREVDKTEPVLAINGSGLLLKAVLDNAKRSNYVDLVLYTGWMTFYNIRALVSYSLVDCMDGGGIQSQIQSATQCLENMAQVSTYAFVRLMVDSLDLQPQVNDTMRTWMAVKEATRANFPKLPWMDESTAAGAIHHVDNLITVLPMPDHLKSDEALEKYYFFLDQNVTQPFIVWFHNTFQRRLQEQKRLMKEDPAVPVHREDIAFGASDVNAFYAPLIHLMVVLPGVMNAPFVPSTVPLAVVTGAIGKVLGHELTHAFDPLFSSLTRTGDVSTWWSEDSFTKFLSRLHCVNSLLTNYTSDPVFSRNALSETFADTAGTEKARLAFGSIQASSGILSYTPEQSFYVAGCFVFCSETAYSWSKSGIYPPMMLRCNLPVHNQERFADAFSCPVDAALNPQNRCTFHVSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFP3</accession>
    <name>A0A9D4PFP3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxysteroid 17-beta dehydrogenase 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFP3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9637" checksum="BB11F02D10CA73A5" modified="2023-05-03" version="1">MTLGEFLLVLLEFVLLNVQCLWIALRGMVHWPAPVPPKSVTDKVVLITGSGHGVGRELALRFARLGARVVLVDIHKVRSVFGPTDPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGW9</accession>
    <name>A0A9D4PGW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048320"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71190" checksum="89EC5235CEAA2921" modified="2023-05-03" version="1">METPKRSREAATFLHFLLTKHRCVTDVDVYVDTFWDHRQLICDALRESLNLRKLTLYGTCTDIHPSRNFAAALLHLNCLRELECGPMFFKHAFIEGLSEFLASTRSLTTLIMPHVLFKEEKDAIVFIQGLKRNETLTTLSLNTSVVKPFDERPTRLGLSRCAVSFVDYLSENQTLHTLRVSTAWQWHDCFLAVRAMIGALFGNKTLTKLSLVRYLLDDEDIQHITRLLSQNRSLRSLNLNACLRRDEISRMDSFLVALTENEKLEEVTMDRTLLNEHEYGSFFKALASNASLKKVIVERLERVNVLDMFRAMREAGVQDRFFVGTHEVNQDTVAALTECKELSSVSLDAHTFRGLEPLLTALFLLPSCSHVTSLRLSLDDNDGRVISPIARYVTGTAALRNLDLFFYATSSGAASDKARREFVHALSANKSIRWLKVSGLRFDKTETGMLADTLQSSRALCYVCLFQRNTESTKSLLTHILSPNLSSNYTLLSMFVDTPCMLDSDWFTINDVVRRNNSLVTRAADFVMGTRRKDYAAATELVHFNPGLVAKVQELATVDEHGAASRIKSSLKSFSELDDFMRLAGVVKHSVSCHRRHDGQKQLVDLNRDCWLHLKQYLKVGDILDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGY5</accession>
    <name>A0A9D4PGY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_011943</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026877"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14051">
        <property type="entry name" value="PTKc_Wee1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000115">
        <property type="entry name" value="Wee1-like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000989">
        <property type="entry name" value="Wee1-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017164">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF185">
        <property type="entry name" value="WEE1-LIKE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037281">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="313"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7939395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="655" mass="73179" checksum="D5538C51939A3E1F" modified="2023-05-03" version="1">MTPCAPRRHHLVVQPTTPMHEGGGDDDQQSSMHLSPKTLFREASDADSRMLDSSPPSSSSDLNSSTDSGVVRSLERSPSVPVQMVMPVPRQETPPYKRIRALRLFGSPQTPKTLLQHAEAPSTVHVSRQRLSQYVKPVQTAALANVNPFSPLQTTPPPEPRPKRPRKSLQRAQPVGAESQSIVRRNNGIRGLLWHVPPLCERRVTEPRGDDTGGGDYKPRRKRESRRRLVTFASAARGPSPAIVNNFLGVGDKRVLPHDRDRVHTPQDVPTPEGGTAEDLWECYDEEMVQDRIVKAQRITRMEPGQSRYETEFLELNEVGSGEFGSVYKCLHRLDGCVYAIKKSRKPMRGTQDEKTALNEVYAHAVLGQHPHVVRYYSAWAENDHMIIQNEFCNEGSLADAIQRNAREGKHFSEKELRRILLHVAEGLRYIHSQNLVHMDIKPGNIFISRVPISTLPESQDDGFDSGSEGPTEEVVYKIGDLGHVTSTKNPQVEEGDCRYLSKEVLREDYSNLPKADIFALGLTVFEAGGGGPLPKNGQDWVAIRKGNLPTLEQCSPEFNQLLTEMIQKVATQRPSASSLLHHPVLVPNATKSRAQLRKELNAERFKNELLSKKLEEASMCLQSLPVVHSSSTQTSRAQRFVGKKANRSHSVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHU1</accession>
    <name>A0A9D4PHU1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHU1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="103" mass="10890" checksum="B0E68B4E21A5F384" modified="2023-05-03" version="1">MPEVAELLASWVDPNPTESSTETENVGQSSDGSNPVPQGGSSDSTNTDSATSTHDCNVERATTSGSRKRPGTSIMQQLLDLHKEEAATAEKAAKKSRKLMEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIA4</accession>
    <name>A0A9D4PIA4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIA4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="15274" checksum="377A0342A670B793" modified="2023-05-03" version="1">MEEMDSKILHMWEAKRSLQERWKGQKHNRRLRKRIVALERDIEDHANRLSQQQWAGISECPKLGIFSEASMIQKAQKQHKDKTCNGYYTATQAQRQSSYASCARHTWEMQQRHDSRSTKERIMSTSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIN3</accession>
    <name>A0A9D4PIN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin N-terminal SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_009215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032638"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003012">
        <property type="term" value="P:muscle system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="10">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7943559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13837" checksum="F3352D6862610B46" modified="2023-05-03" version="1">MAEPAELDAFNSPELKYLVVDKSDVYDPTKQAEWTAKKLIWVPHESQGFVAASVKGERGDELEVEVLETGKRFLVSKDDVQKMNPPKFNKVEDMAELTCLNEASVLHNIKDRYYSGLIYVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIZ3</accession>
    <name>A0A9D4PIZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042673"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72684" checksum="D4B4538AE1E3E5A4" modified="2023-05-03" version="1">MIKKVRIGTEEMDSEEINRRFPAVRLNVPCSAKCGVGGEDGVSISTSVCHTFENLSRWNYVLWHVGLQLRELRGPGKLSLVQAAYRGRGGSMLQARSRHARILIRVLLVQYRCVESLHVEDALEEGSGLGEFRECVVSTFRENTSLRTLILGSLFSEYRSIREELFGAIASMTNLCELAVLGSAAGPSVVLEAVCKLLVDTTCLVTLTIPRLVFDDGSGTRLTAALRRNKTVQNLSLHVSVMHSYMQSGIPRFSHFLANSKQLTSLSVEGVDTVPVSTFEDIKCIVAPCRIRGNLQKLRLTGFLLSAPCSCLFAALVYGKEGCLKSLDIAGCRWRPKSRLQRTRDAGPSDGEQVGRSTMAHRSCHRTQAFGRSARVRLSFLALRLEGLEPEDLRLLLNTALTVEPLKTISLIERLCRMIRETGMSGRVSIEDAYIIDSSGLNDLRGYPEALSKVSIRSFPWQTPRTFKTAVHLACSWYQVTVLTVSLAQSILLNVDTALSLTGCDDPDLSRSLRLASQPYSLLLDMIFKNVATQSLRLNALRMGKDNLRFFVAGVVASKSLCELAFVSCDPAENDTFLGLLAPMFHQNKTISYMRLLESTDCTGDDRLTVENVIGRNIGHLTCAAHYFVGKDYSSRCDAALAVVFARLRSRLSATPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKP7</accession>
    <name>A0A9D4PKP7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_002223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050735"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089720">
        <property type="term" value="F:caspase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7946641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="604" mass="65623" checksum="ADE01AEB614F0628" modified="2023-05-03" version="1">MASMMVGTAVEPRGPLAFPVPEQTVLDGPMGATVGKFPKMAGTADYSREEDRHATFREWPPHAPVSAKKLAQGGFVCINAYRLITRCYSCGLEVSDWSIADVVVDKHRTMRPDCAFVRSLPSPRVSGAASPQSPTTVTSSAGARHAPAMHVDSVAPPLPCINSAPSVQSRPCETVPPGGARNDVPLHRLQASEEERLNTFYDWPLVSPSARALAQAGFYYTHKQDKVQCAFCKGVVHNWEPGDDPLREHARHYPCCRYLLNPDLAGQDVCGRMSWQQARSAPECAQLLINEGPQGVHLKGNTPPSELSGLGVSVHVGPKHPSQASPDARLRTYEKWPTTCPKRPQELVLAGFFYIGVNDYTKCFHCDGGLCNWDSNDDPWEEHARWFPRCQFVLLSKGETYVQDCLKRHQSHLSAVAASASTSSQGQSGGADEGMATELAALMRSEDVQFYLSQGVPAETLRAALLKHMRSQGRGFASRDELLQVLGELLTLPRASADQTPQRLATNSVTITKVATNPEADCIVSRAKNASAESLTEESESSDLALENLRLKDQRLCKVCLDAEVGVVFLPCGHLVACPACASALSDCPVCRASIRGTVRTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLV1</accession>
    <name>A0A9D4PLV1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLV1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042953"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7947542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39955" checksum="13FDC3494B3EFABA" modified="2023-05-03" version="1">MGAAAEAALLCTTVVREIILCLSVEDLFNFARYDPLWEELALPLLSKRLRFFLLSEDKIESPFVSKELTEELRFRLRVAERASRRPALGIAFCSGKRYDVSALSSCFPPEVSVVRIDVRSPIWVQHAHEECRAGCLGVLVLFDVPGAIFECEWSPFVACRQPAAKAALFNRLRRTLRPDCLKPVYQHPTEDSPAHFALYATSAFSKTVFKNSQRMDRMASCVMWTSCLRVLSPPSRRRFLPHAYWGAMIFGDKVRATTVKFRERTSLLRMFEHLEEVRCEFGDLQNALVLVMQENDLDTSVMQAMCSVFTGAAAIVGTSCGLSLDENMFVATEPSEESETSEKLASTVVVALLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PM58</accession>
    <name>A0A9D4PM58_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PM58"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="224" mass="24561" checksum="E90BA53D3590D044" modified="2023-05-03" version="1">MLPSLCPPVKPLNAAYPRAWFLKLDAALAQSGVTAQPLMHAVLLNALPVELRHLAAASTSSLQPYEDLCAAVLICYGHAYRPLRWSREFHASPLLQRAVPTRPQPSLDHDDTSLITAPSTSVPATEASIPVPDHRDKAEDARTSTDLSNTRGVPSKLSAEGPSRLPAIRTSSLTSRLATPRGRQPSRRPPCRTPWSLPRTSSREVFVLPLRRLRRPCLSTNTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMG4</accession>
    <name>A0A9D4PMG4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ran gtpase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMG4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045027"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="80703" checksum="F77D9335ACBF210A" modified="2023-05-03" version="1">MPEDSEAPEKTTGDEAVGSYDSMELCELGLVRATAQVVSIDTWKDQLDFERACSAAVPGERCWLSGELTSWNRVLNSLEYELVETRPGSARLQKADCDDCDSDKSVKDVAREAAVLISWLLEHHLCIEELSLYYPRGYGHKAPPVPFPIRVRPSVGDLFELEGLDTVRGIEKLKVVSSKVTFKFAAQLESLLRRNASTLKAVKITKARLPRNVDYALRCLVNCESLTLCPYYDWGRRAPSLVSVAQLLRTTSALKNLSILICPIKRKKQLTTIAEAVKVNTSLTKLSVSSMEINFSPEPIFVALEANKTLKELQLQECNIGVFSGLALAKALWKNTSLRSLRITESAISADSMQLLAAVLRVNSTLEEIELSSRESLHYSGISVLCSSLAKNNTLKKLTLGKFRATRQEREALAQTLTTNDSYGRVQMSWAKPDINGLWNALISATACPEEVRLREIPSLPKEALELLFNAIASSERVRAFRALWEGNVQAKGAAFCEMLKSNRSIRILDIFIGTGNANLVHDVFHALAENEGITKVMIGLDALESDEAATDISYFLARNKTATSFYLTTVRHSLYEEFVEEFSKGMWQNRLIVDFKLNKNLICDEGSFTVFEAVRRNKAALNRAVDFILRHKADRECAEAFELFSKTPLLVSQAVKVTEKTEGEVLADVVSAANFLTDNYLTITGIVKNSVECHSAEGTQIAALNKDCWRAICRHLKVADVLVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN52</accession>
    <name>A0A9D4PN52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_013183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN52"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22718">
        <property type="entry name" value="FHA_SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="115"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7947554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="233" mass="26151" checksum="EC1815AE9504CC47" modified="2023-05-03" version="1">MTMAVTGHPTPGTIVQTGAAHHAETGDRGGTLETGRSITGARRNPRRSQKKRHVAVKPEFGLSGKLAEDTNVYNGVVIKYNEPVEARKPKRRWRLYPFKGETSLPFIPLHRQSAYLLGRSRLIADIPIDHPSCSKQHAVLQFRLVPYKRDDGTTGRRIRPYVIDLESANGTFVNNKQIDPRRYVELLERDVLKFGFSTREYVILHEESQGEHLDDDVAGTGEEEEPPSNTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNK1</accession>
    <name>A0A9D4PNK1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin-5 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNK1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029139"/>
    <dbReference type="OMA" id="PYDGDQC"/>
    <dbReference type="OrthoDB" id="6480778at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043176">
        <property type="term" value="F:amine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030682">
        <property type="term" value="P:symbiont-mediated perturbation of host defenses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002970">
        <property type="entry name" value="Tick_his-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02098">
        <property type="entry name" value="His_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039021576" description="Lipocalin-5 1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21189" checksum="B8657DFBAA0E450C" modified="2023-05-03" version="1">MRTLHVALAVAIAYVTFVAFPASSEAPHKLQRNLTDTFELFDKFPYVVLVYSSGDDPEFQCLTNKRTELDMKAKKATYVWMFKGHNGRERKNVALHLSAGDAPDRVVFTINNDTEHSMVAHFVYTDYKDCVIVEIPYDGDQCQLWVSKDVKDDVPQHCLDQLEDICDVSEEEYSKELCQNEVDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPA8</accession>
    <name>A0A9D4PPA8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPA8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029070"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043501"/>
    <dbReference type="OMA" id="QIQEAAY"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="306"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7948020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1105" mass="126823" checksum="B43D966D17F87A03" modified="2023-05-03" version="1">MILRNAIAGRKRTRQSEDDGTDHSGLDPDDFFSELDDGLNESNDNSSEVEFGTRSRGKRRRVGEGGRGRGRGRGGGRGRGARRNASESITSEDPGTLYDVVRLGRHSLTAVVDDWIESYKQDRDAALLDLMTFFFHCSGCKGRITPQMQVTMEHNQIIRKMTEEFDEESGDYPLIMTGPQWKKFRQTFCEFVQILVRQCQYSIIYDQFLMDNVISILTGLSDSQVRAFRHTSTLAAMKLMTALVDVALNLSISLDNTQRQYEAERQKNKDKRATERLELLMTKRQDLEENMEEIKNMLTYMFKSVFVHRYRDTLPEVRSICMLEIGQWMKRFHQHFLDDSYLKYLGWTLHDKVGDVRLRCLQALLPLYSSEELTSKMELFTNKFKDRIVAMTLDKEYEVAVHAVKLVISIHKFHREILTDKDCEHVYELVYSSHRAVAQAAGEFLNERLFQPDEAAVQGLRTRRGKKRSVNTPLIRDLVQFFIESELHEHGAYLVDSLIDSNPMMKDWECMTDLLLEEPGPDEEQLDDRQETSLIEIMVCCTKQAATGEPPVGRGPNRKQMSNKEMKQVADDRVKLTEHFIQALPSLLSKYIADQEKIANLMVLPQYFDLEIYTSSRQEKSLDSLLKLIQEIVERHDNTEVLETCARTYEALCSEELAVHSRCAVSRGTLIDSLVGRYKQALSAYAEAGEDADDDDIYAVQSALKKVSIFYGCHNLGPWTIWEGIFDYWVKGAGERSLSLEGVKHAISCCSSGIMWDLAVLDEGNIQMAHVHALRNRLREFMDTMVYMLRHCTGALQEEAFVSICDLLMIFCRQLGDSEPFSALVYEPDRALQANLGDFIQHNVFVEDDSAAEDEQDEHRKIEELHKRRNFLASFCKLVVYNVISVRPAADVFKHYVRFYNDYGDIIKATLGKAREINKVNCARTMVQSLTSLFSALERDQLGNISRQDENFVAIKELAKRFALSFGLDQVKNRDSVAALHREGIIFACTPFENPLNPLGPPPNLPFLELLCEFTNKLMKLDKKVVLQYLDRHVQAKLPASRADDWQPLLLYRTSLVHGEAEQPVARAPGRQYRGRKRQREDDDHAEEEEIDQDSDRGSESEFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPM7</accession>
    <name>A0A9D4PPM7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 2 winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPM7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047684"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="2">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7950777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="240" mass="27007" checksum="3DEB79D88B00B7A9" modified="2023-05-03" version="1">MRLLQEFCTAEDFCTVDDNIATCGARTVEDIVEEATCEVADSSDDGDDIDEGDGEGPPAAAETLRALDVLRRAMAADEISDDTCTRFYGFQRSLLMWNQETSRRFRFVWINATTFEPYALESSLEPLKSSASNALSSLKHVFCSLTPNARKIFLLIARHQLDNTESPSYAGMSFHDCYHRCREAFLVNSDLTLRAQLREFLDHMLLKIKKGHDGTENLLIPIEAAALMLFLDQQEEDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPT9</accession>
    <name>A0A9D4PPT9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPT9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028324"/>
    <dbReference type="OMA" id="NAYFFYR"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="277" mass="31985" checksum="1FB5E80036107124" modified="2023-05-03" version="1">MAASALASLRDLYRHVWSFRDPRIEGWGVVTEGRLIIPLLFAYVYLAKIGGPRWMKNREPYKLRRAILTYNVATALVNAYFFYRYARVTYFGGGYSFFCQGINKGGYSMEVLELNWWYVYVRIADFLDTFFFVARKKFSQISALHVIHHFLVVLSGWVWLNFGNEGQALLGLLINQAVHVIMYTYYFLAALGPAVRPYLWWKKYLTSLQIAQFVFVVVHFTIPIFYDCGYPKPLAAFGVAQLLLGLALFINFYVQTYIRKKGANKDTSLANGKDKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQG1</accession>
    <name>A0A9D4PQG1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_022948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQG1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027592"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7948458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="302" mass="32249" checksum="A8F88FEB14FD9D40" modified="2023-05-03" version="1">MPGPRRRTPGVPQDLAQLGPSRSGPSTPPPTGRPRRRPAPPPAGSPAPPAPQRHRPGSSTSASASDGTSTPTSSSSPTPLRSRPSTLARGIVKIFPVPAVLRCIRRGCSTSYGGASWTSRVQSLRRHLEREHGERVREHLYLFSVCSESLPTRPSCDPCLASTTTPADTAAPRHRCVRCPRAFPSARGLTNHERWHDVQDATAAASRRLPPSTPATRPPPTSEQPPSLSGGPTTPDSSPDRHRVSDSMGTPPPVGDASPSRATPPIPAKDPPLKHKPIGFRPGGAWHAQSDLTSFIRRRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRM5</accession>
    <name>A0A9D4PRM5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRM5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030315"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="732" mass="80610" checksum="2F4EB66EC179DBA1" modified="2023-05-03" version="1">MPAPCPAHLSTGASWRRGKAVGGRLRLRATAKTTREVTSFGTPYVIPSVERFSLRGCGHIGSRNWRARVGGTTWPHWGKGCSEGGKEADRGKYVSLSKAVLQRGSTRVSRGVDDVQPSACKSPPRPSLTGHLGDESSQAWDSTGCEGEATLRQRVKIPCRALGAGGEKAAASAKQCSTRTRVLRTPGDSRRGRLARFKPSTGRRRIEAEGYSKTSAERRTGATQRSSRRTHDQRYGRLWRHNEEVGNEAAGLEEPESHSEVEVLKMKIRLRELELEIAREQRGSGPTPRGNGGQESHGEMRHFSKLISSVLPMFPTEAEVPVWFEAAESALEGYEVPKAWWGQIIFPFVEERIPFLSTRLAPPQHRDYEVLKGAVLEEMKLSAGEYLRRFHRAKKRAAEGWRAFATRLQSYLQVRAKLTMLPLALARGTGVFADGKAAVPVLCALTNKLRARTDCLLSEEAWTLLKEADRVRQQTAHAAQPDRRAKPSGVRVSEAVLAFDEQCSGKMFPKRKGPGRVRGRHRWRRRRGKGNTVVAGAPGLERSAHHRKGSAHVNEGTVLRVPNACRYPSNSAGQSAEEGECSPLCTSNTELSLELGEGRWRQYAGTVSRVNRGTAWGLQTSVNGGKLAPREGSRWPVAAACYRENNSGGDLIWNTVRHPFGGALFPPRELARQSWRDHVAALGKGVLRRRKRGRPWEVGQSEQGGVTARQYSGLPSLCLQIATTTVADGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRT2</accession>
    <name>A0A9D4PRT2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRT2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042438"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11791">
        <property type="entry name" value="SH3_UBASH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000052">
        <property type="entry name" value="Ubiquitin-associated and SH3 domain-containing protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="380" mass="42481" checksum="52A614F8959D7E50" modified="2023-05-03" version="1">MWLPRQGRPHPATDLGDDLSGGGFPWLPSPPLLGVRTLPPLPDSKHGEGPRLLAHVNDPTLDDSTPREYILYLCPVGPLLEQLQKFSLQSMLQCGRNGAHNYLPHITLCSFFQAPDDAIGHLSRALQHVVEKLKPELPESIKLEHYTSQTFLGLFVAEEHNDALKKLAVYFMREVSEFSIQVEPYLKALHITLAYQFQLEHYATLEKLSQAINTNTAACWELRLYSRDTRIKGCEVHKVLYSHVPKEPDELELLIGDFVYVSGEHLGAATDGWVEGTSWLTGATGFLPKNYIERTAESDAWTLHRSITIVKDVFIDGLDDGVLQRRPAVAAAQAPPSPQAADREEKVTTPPKEIIYENLGFLNQAVSEILVHIGVAKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTR0</accession>
    <name>A0A9D4PTR0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_001032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTR0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039753"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052610"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039499979" description="Peptidase M14 domain-containing protein" evidence="10">
        <location>
            <begin position="35"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="346"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="946"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7955482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128426" checksum="85C4342656DB4776" modified="2023-05-03" version="1">MAPSRAPDVYDRSRCLMTPLVIALVSLICSSAASESDASFPVPKYLDYNETTTFLHNLASKHRSLASVYSIGKSVQGRELWVLKITTDPNVRSIGKPLFRYTANIHGNEALGRQLLLFLAEYMLENYGNDSRITRLVNNTELHFCPSLNPDGYANASEGDCEGASRDSGRFNSHIVDLNANFPVGREPETLAIMKWSVLNPFVLSASLHGGLVVVVYPYDYRSPDAPMDSPNLTPDDDVFRHLASTYARKHSDMFRSPQCQEYFDGGITNGAEWIPVSGSMQDFSYIYTNCYEVTLEISCCKYPMANTLVSEWEKNKNALLSYMEQPKQYAPLDTDFVFSTKPEFKHHSQEELVAIFTNVTERCPAITRLFSIGKSVEDRDLYFLEFSDNPGHHEPGEPEFKYVANIHGNEVIGREAVLLLAQLLCEQYGKSRRLTTLVNNTRIFLMASMNPDGYEKANVGDYNSVVGRFNAHNVDLNRNFPDQYQPEKAHHPREPETRAMMNFIVARPIVLSASLHGGALVANYPYDGNKEKVERIYSATPDDSLFRYLARTYARAHPTMSLGKPCPKGPMDDAFKDGITNGAAWYNVYGGMQDFNYLHSNSYELTIEMGCYKYPPASDLPKYWDEHKHALVTFMEKVHQGVKGFVKDEDGLPVPNATIHVLGIHHDVHSAVDGDFWRLLMPATYSVRAYVDGVCFPLPVQRVTVLEGNATWVNFTVDRRYAKWSREHDFLIGENGEPKYLGADELANLLMQLRQNYSDIVEVKDSFGPPGETALQFLRITVPRIVDLLEKVVVHIVPSVDKAGFSHTEEGICDSEPSEELNMEDHFSSEFTGQFPIVEAVKRAWVCRTTWQALFSILEVLVSGVHGSVTDEYGTTLTKATVGVHTSKRPIETTSGAFCLAVPPGKVVLTASASEFEMRVERVTVLAGEGTSLVLVLEPDTYEHKYHSYTEALQLLRYIAHNFVNGALAYSLGSSAGGRDLPALVLGATPRVHRPGVPEIRLQAGLAGGLQLAATEMLLHLAHTLATRYKHNSLVTQIMASARIHIAPMLDPDGITNSSIGKCDANESTLSGSSLFFMFDGSSSRPEVRAVQQWTDRYHFVTSLNVLTGGLALALPKGAGAIDMAVLRRLAKTYAYHNDDMLNGAFACANKSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTV7</accession>
    <name>A0A9D4PTV7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045483"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16189" checksum="00ACAE3D3FE31C0C" modified="2023-05-03" version="1">MFVKTVRGECASWEEGVVRQVVSAVTYVVKVREQLRFTHADHLRQRHADPTPSLNLKSGLGHPLTPHSDVTEEKSPAAGNSARTSVPDKLVATDPTPPVQQPIPPVNVNCPTELAAPTSQTEPRSASPSAESQLLRRSTRTRKPPDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUB2</accession>
    <name>A0A9D4PUB2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUB2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026825"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7955903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="462" mass="50028" checksum="55461C5514D8D74D" modified="2023-05-03" version="1">MAACGLTWWSGSVARSSSSQAQGAPGAHPRGRGRLPDGELPPCVRDSPLLMGLHLEAQRLQQELRRAQRAYWDLVLGSDCGDDSAEVVVDLLSQLEKRDTELSRARGRCERLSEALAQSEREVAACRDALHDYQLQMEAQRATHEAQRSRVHDLQVQLGEAREGCEFLQAERATLAEAQLESEAEMRRLRGLLEAALETSRILYQRCAKLFAKCQQKSVRLSQLESQLECQRPIAEATASSGQALAQLSAKLQAFLKTSVLFAASHLQLDSEVLDEIMDDLEGSGDEHPPAPAVPPPSKDRLAPLDVSFANGDSEPDSSYGTPVDELPPSTSAEHSSLVHAILQAAAGSQLLARSEDLPINGESEVHDKLAERRNLCVVERTLVDCNGVSGEGRLGGQVPPAGSIAEEAGLQSARSPAVSHTNGFRVDDGAVMFRPNQCSLPAYLAVVGAVPRKMGWEVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUH6</accession>
    <name>A0A9D4PUH6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044081"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10710" checksum="AE4124FE13359F53" modified="2023-05-03" version="1">MQVWSRQYGQPGQRWLSGTVTTVEGKRLLTVNTPRGVQRRHLDQVRARASSTPVKEEPFETPVTLEHSSPEGPLSSAGDQTTSNDALQAGQSVPGEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWH6</accession>
    <name>A0A9D4PWH6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_009729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWH6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028748"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7956444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="394" mass="45186" checksum="D012ACE29E1AEB7B" modified="2023-05-03" version="1">MATFPQSCDNNKKFFLIAAISLLSVVSTIHLEKLANAIAAPPSISPIVQHDERDAPQAAFRVARANECPHKIDSRDVHGPNKDWHTGGWAVRQLCSQPVDTLFFVHAGPSHWENRINLRATLFEEAARAAFNWTGVFFIGQHVDPLVNLWTKLEAKFTGDVVIFPHPDNFSTIINKFVRGMRWVTQYCPKVRNIVKIDHDVGVQPFELRRYLDEKLPLENGSISCLVWKYARVSRDARDKHCIPVDDLPMDFYPHYCCGRAMIMTTDTMKKLYRASKFVNGYQMDDTYVSGHLAMLANVGHVDIGSNMSFDTWDVNTERMLKPNAMFTHDHSAYGNSVGRRAQWELMIWMQMTEAPGRHGFNSSYRLVDQMYRRVFHETRRALGGRSQLPPRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWQ0</accession>
    <name>A0A9D4PWQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWQ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054224"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="960" mass="106997" checksum="E33275951057C855" modified="2023-05-03" version="1">MHHHDSRTTTRRSRPNKSNSPGTRTPRSSLGEQLPGYLPKGRVSPKSYVPPRPRTATGQAAYLSESPQGSDYSPRSDSLRKHRDLPSYPESPSGLASPSGGNKGPASHQRRQPSPRTSHRTLPTASRDLSPVLSMESPLESLRESPILTPKECASPPAGGSMSPCRVETSSPQAFATSGLGTPGSHASSRKRGGSGRVSWQQAHLRAEASAKRHASPPTLYRWLVSRLPWSARRERVAQERGPDAEAVTLDRTCRTSEICSLRPFWKGTSSVSGPDAPVMTRSSLRADLCTAVLAVVVVVLATSLILVLIMGGVDRKPIAVTAQRCITDTCIKYERLLSLTMDTSAPPCDDFYQYVCGTWLRTGNRPIYERNWDRFLNEVGRRVMALGASVKEGDSAGPRQSNGNIGAAGEDKALTSIRACLSPLKRDNMEEVKDVLAAAGLPWPDRSAQPNVIESMFYMSRRVYHALFVDIVESGKSNEADQPSLAFFSDVQFIRVYERIGEHVTTGHDRDHFRTCYESFANDSDASAHKQHQEQLYRRFKDMKSFLDAQMVGVVANSSRPDPATFLSMTLPVPESRWEAASRRYFNVSLRSFNFTYIENEGQFSALFRAWDVYGEDNVTDFFGWFAVQVLLPYTNRRLLASYFQSESMGGDEMRESCVFTAYTAFPVALDNFLLRDVLEAIQYARDLMDPISDSFRRLLSANLSSLIGDALPQPNATRVVDAFEILNAYSEATVYHLYEDFPDVNPEQPLRNAIKLKRYMYDRNERTTTYRAVDANMYDGFHLNPQLLSFPWYASDARPAVLMGGLGSRLAGTLYLDFVERRPNPQAVYRENWRCLGLKDIDDDSHVDLVAATAAVNVVWDTFWNGNLPRRVPLQATSRDGNASRRVPLSRMTSEHEVPANYSDPALLFVFNCWLTCGDQWGPSLCNVPLKHSPHFAGVFGCPPGAPMNPAYKCRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXT2</accession>
    <name>A0A9D4PXT2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactosyltransferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXT2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026666"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="15328" checksum="F493A3B1C173D817" modified="2023-05-03" version="1">MDVPSLEAVEDEFPDVMPGGRFQPKECTSRHRVAILVPYRNRTEHLKIFAYNIHKVLSRQQIDYGVFVIEQGDSAGFNRAKLFNIGYVEATALYDYQCFVFHDVDMVPVDDRNVYTCPEQPRHMSVNVNNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY91</accession>
    <name>A0A9D4PY91_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large subunit GTPase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY91"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037680"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7956583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="11720" checksum="765C9018ED6D0B61" modified="2023-05-03" version="1">MTASYSRVGYPNVGKSSTINALVRSKKVSVSTTPGKTKHFQTLNLDDELCLCDCPGLVFPNFVSNKAEMVVHGILPIDQMTDHVPPVNLISFTALSQPLESLKLCKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYR4</accession>
    <name>A0A9D4PYR4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYR4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="21626" checksum="3DCB191345AC91FF" modified="2023-05-03" version="1">MVQVRKGYGDPNTKLAELFKVVKLATKEAVLKTIGYTTESGAMEIAAIADGIPYLERRDETKPGRPGRAWRILRRTGVPDQALRRVPAVDVRAGPTESGHGAEAAGVRYNGLLSGLGATPGASYRQDEVDVGDATAPYWKAKLGWILQQIGKFLQQSAPSYSSEDGAVKPQDITAGQIRKVAEVLNKAADAVEKGDDFNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZE4</accession>
    <name>A0A9D4PZE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029869"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049026"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="74196" checksum="010F1CF0981EEA4F" modified="2023-05-03" version="1">MISRGVTTSDVSGHVSSALRRYRLLGRRLAVKPSPQLLLGSLLVCTLSPVCSDCYLGRCFLSSSAAPPLALPSAAIAASINRVQSSVLPTDVPLLEDMDVLHAPDNLTASVEPPTSTRNSAAVVMPSRVLLLPDTNPFAPLWELEEQNNIEGKSDNASRQARIISTAPNGEKRARGSLLPTPEREYTNVPGDFSHARRASHMLPASTRHQDEGGSWLPVSYRRKQQNRATVAPTPSSGSPLKYPHTEDPLPEFTVRYLGRSNQLAVDAAEPEVRNALRAIASLPLSGKNVPFHAYEAVSQDQIRDIIRNAGDMTSEQLMKSLHCRKCKILQARPIGHKGTAMVIFEGNSLPYKVGLRSFTIRVFPYRARVSVCDICHKIGHHKEQCPNTMTARCSTCGLRQHEEGTHCPNAEPKCRSCGGSHLATATNCPKRREINKKIEQKRKPAAKRQRNKREAQGHQRRNPETEQGSPRTILKPTRQSFYTGPPARPAAQSEVGRGITFADVATQAKAHLTNGGSNGEPHPSCSTLASSLSQPASACRLGIKQCSPRGRRIMQDASEYRLTLLNTPQTHTRLAQTARQADTSPDLTWSTRPQLFRWEVLDDCMGSDHFPILIFRTGYANTKKPNATTRLSHITHWDKYREFLQQQPPAKNTDAWYRSYAQQSGKPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0G6</accession>
    <name>A0A9D4Q0G6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0G6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18228" checksum="F48DBD21E23602B0" modified="2023-05-03" version="1">MNHARRFGFPDTGGHEQILRREEREALAVPKTGASVREPRASMREASQSWNTVGTGRRSTEPASRTEAPVFGTASGSSSSRRKICSWPPVSGNPNLRAWFILPGVVRTASVAGSSPGAEETLGATDNDGYRVPSGGSSTRPIILAAATPLPRPATHDYVTARTLAVHHFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0U3</accession>
    <name>A0A9D4Q0U3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_015941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0U3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056137"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="7">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7962404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="361" mass="37057" checksum="3091D13D3B31D4BD" modified="2023-05-03" version="1">MEVLMEEGATVVTSSAPVSRASSTTTAARSSPAPSAVVVTSAQGRTNGTVVFASPAQVKQLNVVPSATTQALAVQQPGGGVSIVHVSIPNQPMHVQSVIQPNQQSVIQAAGGAAALQTLGKNVILVNKGSVIHSADGDAGVHPVQLIPASKLDVSGEAAVLTAEDDSKKRREILARRPSYRKILNELSSTEAQGAVASLTADTKDDDDDPDNTITVAGTQYHTAAGLLKVVPASAIQLAVTQEGSLQGLQTLTMTNAGSGTAAGTIVQYAQGQDGQFFVPVTVSAADLQAYQIRTTGSGGSSQALAQSVVMGPAPSLQTQQSLAEEASRKRELRLLKNRNASHSNYITLQHLCKAVGGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2B0</accession>
    <name>A0A9D4Q2B0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019516</name>
        <name evidence="5" type="ORF">HPB52_019517</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2B0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7963085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="60" mass="6991" checksum="CD9665FBA7F91DF3" modified="2023-05-03" version="1">MTVIGCCHSGETAPYRTKLVDRDITPHRFRSLISKKGNHWYFRRSCQELGNRRGVRRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2D7</accession>
    <name>A0A9D4Q2D7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysosomal acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_017780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2D7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029542"/>
    <dbReference type="OMA" id="IDESPRI"/>
    <dbReference type="OrthoDB" id="6418769at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038388478" description="Lysosomal acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47593" checksum="30E97313C9D69CF8" modified="2023-05-03" version="1">MKLTLAFALFAFILDSTRQQGAGQANDSSLVLLQVVYRHGDRTPIRTFKNDPIPITAWKEGPGQLTKVGCLQHYTLGSRLRSRYANFLTGNPHKLRVWSSDKDRCLASAQCHLAGFAVPSADWAWNQTFHWQPVAIHTRPTFEDGMLVPGDAYCPEATAEEERVKNSPEGQAFLKKYHKFYEMLTEKTGNIIADWYDAEYVYDALLIEQYHNYTVPKWAKDMWKDLKYQSDQSFVFRTKTRLLKRLRAGLLAANMSGNLEAAAQNMSQYKVFMYSTHDTEISAILDALGVFDGHAPPYCSSLVLELWKNGPGNFSVRGLALNAFDLEPQPFHFPGCGGEFCALEDFLSLVKMYIPDDWRRECGLRRSFFLSDGALALVIGQSAILAIVVFSCTAYCLLRRRKTPKNVVAYSPLPTEFTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2I7</accession>
    <name>A0A9D4Q2I7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Retinal homeobox protein Rx</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_020239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2I7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038187"/>
    <dbReference type="OMA" id="KETCRMA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000071">
        <property type="entry name" value="Retinal homeobox gene 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="12">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7963242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="36227" checksum="A43AE43CE7DA6811" modified="2023-05-03" version="1">MLHEAPARDTGGCGDVKEPAPSTKGVERRLVHAYSIDAILGLDRSSTCSEERRRVPVVYHGGTRCTSPTGTDSGSDTASNAGLEVSSGPELSPGTGSRGSPGPEGATTQLPAEGTSPAPGGSGSSSSLSPAGAGAASSKKKHRRNRTTFTTFQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKMESQSALQHRLAGGGSSPGPGVTGAGAGCLGAPPALPLDPWLAPPLLSGAPFLAAAAAAAAATQQPPHHHHHHFYAATTAPFHLQGMAAPSSSSPLNLTLSNEPKPQPQSAEEEDESASSGRTSSIVTLRLRAREHVQLLCKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q349</accession>
    <name>A0A9D4Q349_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_019895</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q349"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041273"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053416"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7963172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="699" mass="78380" checksum="7AFE7F64413EF353" modified="2023-05-03" version="1">MAAPTEDDSMGSTARSLDSDQVHVAKCLEEFESCTKKPETFLEVQLEVAETMKRLTKDLYDVMDQWKGKTVSSSKTELPSLVVDNFDDEQIWQQLELRNTRLVKDLISSVSRVATKSSISFGVDLGKQESQQRPEKHYPGEIDKLDLADVAAEEEDDEDDDFDLSDASEGDEDSEEEADDDGADGSEQGQARDTQPSSIVDDAFFRLADMEAFADREEKVANAPGSDSDEDDDIDYFRELSSDEDDPEEKGGRNATYNDFFDPPASMPDSKNAKNADKAATRTNGHRDTNQNSTAKDDVQKSSFEQSQEFIKKKIKQFEERNLEPRPWRLQGEVEATARPENSLLQEHIQFDHATRQPVAITDETTKCLEDVILQRIRDKAWDDVERKTRPTEEPFELRRRVTLDQEKSKLSLAQVYEQQFLDKQKAADEDALPKENPAHVEIRTAMRDLFTKLDALSNFHMMPKPVSAEVKVVSNLPSLSVEEVTPVGVSDASLLAPQEVKTKPKGELVSKGERTRTQKMRERRLKKALQKRRAAKANNKAGKVTEEKRKVIKATNTELAKPVKGAKSAKGAKAVKPHNSPEKALAHEQLALKPVPDDKAKEILLKRQTKAIRDVREELLESRSSVKTNANDSKGLRQRVPGQGGGEDFDAVLRYHNSMQEKIAEEMVSLAQNLKQNAVLAGHIVKKDTEDTAVSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3E5</accession>
    <name>A0A9D4Q3E5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3E5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055797"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="481" mass="50447" checksum="E7E2E6BE3E629509" modified="2023-05-03" version="1">MSAHSSTNAVSPAGSSSPDLGDVSSASSAAFSPTGNALLSEIADQNSEEGLNLTVRPDPTVASTNGRHIPATPPDDEDAISSVSQTTAVPSGLKSDLGTRVQERACQIEDTAYRIPVNARHFIMARVFELVKLCSDLRVDAASERGAVMALQGQLVETRREVAEFHRRAILAESRTTTTALADAAFPPAAGPSSQPQHGLAVGPQAGLLPSTAPTPPAMTYAAALQVGAASAAPPTGPPGLTSGPGPVLHEHVAFVTPIAPTSTPAQDSLRLLKANIDPAAHDIRDVTLRQTRYGLTVFAHSRATLTNMRQAIADDTITCAALSMRIPEKHNPHMRFSGVDPDVSADEFVARVADRNPHLQLDPGKCKVSASFSERSGTSAIIVEVDPDAFTRIMRQQCISVGWTSVRVAEDLHVATCTFCATYGHGRSSCPVRNDPAHAVCTRCASEGHLGANCSSVDVLALTQRVTQPVPLIVPCYSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3T6</accession>
    <name>A0A9D4Q3T6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_021638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3T6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="321" mass="35652" checksum="14F359864B1C12A2" modified="2023-05-03" version="1">MYQQAWPVYRGRGHIGGGGLDPNERNQDTMCPNPLQNIMFVSTPSQENVKRYVNAQAITVACQEHDVSAYVAAPNATCKAVIRGIPLSDGPEAIDHKIVNERNPLALGAKGIMSTGVTIVLFVGYKVPYYVSYGGTLINRSVCYACGRLGHRSDICPTPDASGCKACREAMKLDEDEICKPICSLCGDRHLTASRDCKHGYQTPYVVRRTRDLRARATQGRWLSSTGPDRTITSWRPMQIARKIQTQRRQWEPLHILGAAGYKYAPGLQLSAAVHANEDQGRRKSNLTWPDRVRSSDAEQRMQCDPPPELARDADVSQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4U8</accession>
    <name>A0A9D4Q4U8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_005561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4U8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032852"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="357"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7968076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="584" mass="64779" checksum="D04E7967B10ACCBE" modified="2023-05-03" version="1">MTCWAVQLRAAGNISGEEVLRHAFPLAKLEEFADEYAMVANLSARINSLGLANNYGVVFKQAERGTLSYTLRFPSWQEFYTRQTMRPGGATIRPPFWLSGILLPMVSRLNMAVARITSSIADGEQQPPVYFQTRRFPSPKGFDSSRSARKITDVSVIYGFIVLAPVAVKRIADEKSVGMKELLRIAGISDAVYWLSAFLSSLMVMSLETVLITSFLTFPIFCEPAILPQSDISLVLFMLMLYAVYCDLFCLLISCVVKTHQGARWSNIQKAGSPYDNVTLTVMFCVVLGYCVLYAVLVWYLDNVWPWQYGIPKEPLFFTKVSYWYPKAPTNLQYQRKDATEASIPRESIGDRNNPGIVLDNVTKVYSKNTVALYRVSLKAYRGDVTVLLGRNGAGKTTLLRLITGLEQASAGSVYVAGHDAALDTDAARRSMGFCPQENVLFLGLTVLEHLQFFARIRGDSWATANNAIEEILVAFNLSDKRDTLASSLSWGTRRKLQLGIAVVGNPQIVVLDEPTAGADPECKGALWDCVLRFHEDKTMLMTTHSMEEADTLGDRIAVLAAGRMRCCGSSLFLRNTYGIVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4W6</accession>
    <name>A0A9D4Q4W6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4W6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030943"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044582"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7967972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="18066" checksum="8FAFA62D14FA9FB2" modified="2023-05-03" version="1">MQPVRSSNDLQGLRCLYDTVQSQTRALKYLGVPEDNYSAMLYPILLKSLPHDIVIDFTKTIARQSTQQRGQGGNTGQHSQELKASIQSLLFFIQNEVESRERSVLHISVEENAKMVMLEETQTTEDGQAIAEGLCKELGIGDESLISGSYIDMLPHQPLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5L4</accession>
    <name>A0A9D4Q5L4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5L4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17137" checksum="08540BDE53674174" modified="2023-05-03" version="1">MKQTGGNEACREAGGTVVVKSSEDSGGEVSAMAQNQAPEDVSAMSVIVRDAQTDTNTPLSITVHVNESPLPLKAVEMRVFGEVVARGNQDASPSSSSSSSEEEEESSSTSESSSSSDAPSNQAHAKDYLTPEAVKQQMIAQYVQKPQMQRQQLLMNMTPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6C9</accession>
    <name>A0A9D4Q6C9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6C9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028661"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="18020" checksum="B5508D60F9A70F49" modified="2023-05-03" version="1">MLVCLSDSDSTSSDSSSSSDDDEPYVLYEGMFKEMFPVPPCARPKIIGYVEEVVHAYSEEDFRRNFRVSRAVGADLYNDFNASRMSPRCDSGGSPAKTAEEHVLAFLYAANKASIRGFGLRETTAFRVLERVMDYLTLAEWGETGANPALNPGLQIASTLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6N7</accession>
    <name>A0A9D4Q6N7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6N7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028693"/>
    <dbReference type="OMA" id="KQNHRTI"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7969294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="14509" checksum="7129A1B76B845A80" modified="2023-05-03" version="1">MAERPEDLNLPLSVVTRIVKDALPDGVNVSKEARAALAKAASVFVLYTTSCANNFALKGKRKTVTGSDIISAMEEMEFESFIDTLSGNLEQFRQGKTKKDANRAKKHQDASDVVSAGDAEMVDDGEVDPGDEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7K3</accession>
    <name>A0A9D4Q7K3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7K3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058277"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35192" checksum="0E82093AA0B2131B" modified="2023-05-03" version="1">MSIDGTMRYRTAAGGKRAGARHVTMWAAENYAPGLIAISESAGENPLQSQRPKWRRLCRYLGVLAFLSVLGIGLCFAIALTFAQPPGHASWEYLLISSPIVIPGLLALYLCTRRCCGLILNLVFAFLALLCGAVLVATETLASIGIMLTIVGGLILAVILVTLVYDRVTGRSYDDDDDYEDGELGSGVVGVTGSVRNRSLRRRAGDLLFGDDISQRAYPNCAPLRRSFRLASQKKKHHPPTQVQFIVPELPPPSSGLHSRNSPEHGVHTQGSSTAAAGGECPATPDGMPRGHHEASVASTSGRPGGACETAHVCPHAPSPQPQLVANEHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7Y0</accession>
    <name>A0A9D4Q7Y0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7Y0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031108"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="252" mass="27430" checksum="9FEF8EF68760FA41" modified="2023-05-03" version="1">MGNNAASLSVSAMAGTGNEAECLSPGPSGSLGRNNLDVEHGIETASKTLRRFIYLTSFLQGVSCGILEPFCQNEMLRDIKMRKLFSWGLFIEGACCFAYEILKPFNRSLLTGIIRAIQGTGASLVFPGYFFVVCVQFPREIPTLIARVLMFPFICVGCLLIICSFWAPFMIPQYRQKHGGFKVGIGSFLADASVLMDLAIMANAFLLFVSNRFSLADVLLKARIRLMSLLGVGVSLAGLSIAASLEKFLDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAT5</accession>
    <name>A0A9D4QAT5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAT5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049852"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="14270" checksum="431A76632827FC62" modified="2023-05-03" version="1">METLKLKRKAEILKLTRLITRIEAMLTQESVTGEELYILNEHLKHLHTDLRATDFHIIPLLSTTETQAELDRVVDYNDRATVTSAKLWCRIRQLLESKKRALLSTEPVQRTPSPLSNFRKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QB29</accession>
    <name>A0A9D4QB29_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QB29"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7972761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10047" checksum="4F0C68D471621A7A" modified="2023-05-03" version="1">MTCLQQTVPTASVPTAAVAAVVAQGNAARSTTSMRPADTSDYERVSMKCQDADAQGKVVNLTPKHPWMNEPEIQPGCFWIVSSRCSSKHGGAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBX2</accession>
    <name>A0A9D4QBX2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBX2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7973211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="199" mass="22083" checksum="FA7A060B8FCBC13C" modified="2023-05-03" version="1">MVAEQLVRDLKRKAAQATEFLWASWLKGLLRIKNVEKRPPRKNGVLVPETRIRIPEKISEVLNKGPKFSHEPSLRPQELLAMNRRISGKAVKEDQESCLLEGVDVITGVARGGGLKTRKDLTACVVTFFKGNDLRLVQSDEEGRFVVFSAGAYDEKALGAIEKNFISVKQKATKVKKKAAVLCEDLGLTKLAKGVKDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD62</accession>
    <name>A0A9D4QD62_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_008637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD62"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042614"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="309"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7976096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="665" mass="76215" checksum="F7EA301CE49994A4" modified="2023-05-03" version="1">MAWLSDKKNAEAVRVVSIVQQADGCRTEDLWLELRRAFDEIQEKQSTSQRFDELYGAAYVMVARNDGERLYRGLREAVTEHLVKKVRALVLAAVDDDFLRTLNRAWEDHQASMRMISDIVMYLDLVHVPRNNVDSVSEAGVLLFRDRVARYGDVQDRLRETMLGLVKTEREGESVDRASLKKACEMLVALGLGSRSVYEEDFEVFFLAETAQFYALRGQFYILTMDAFEYVARVERDINEESERAKHKHLRNLGRSIVKEHGDSVSFIPQVMDLRDRFVYLVQHSFEDDEAAKLAIATDFEYILSLTNKSPEHLAAFVDDMMRKGIRHMTKQETDQFLDRVMAIIRPLQEKELFEQYYKQRMAKRLLLNKSASDEAEKTVVARLRKECGCLFTSKMEAMFRDLHTSDNTMKEFKDATSSSRSNIPSAPWSVFQTFRRFYLARHSGRQLNLQPQFGWADMSAEFYGPVNNEPSTSQASSTPSGKHHPRTYTIEVSTYQMCVLMLFNRHEQMRYEDIASETNIPETSLVRALHSLCTNGASEPVLTRAPASNEIGNGDVFGVNESFTSDLQKVRIESTSGNMSAPKNSQPAVNLDEDRRYALEAAIVRVMKARLKMSHDDLFAEVTSLLRATYTPSPTAFKTRVDALVEKVYLERDADNEDVYSYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDN6</accession>
    <name>A0A9D4QDN6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDN6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028464"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15767" checksum="0C908932F5E1218B" modified="2023-05-03" version="1">MESRCTFALKETAVIFTVAGILIVSLSTATGQSVDRCDPNSVKVCYAMYMTVLWREEFKPSPEGEYDEEELNRGCSENPAEIACFDKAFNSSCPLSMKTAKAAVTRVVNAASLLKGCKSSSNGVVVSRGFLLLLVVPVILSWLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDW5</accession>
    <name>A0A9D4QDW5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDW5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032752"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="9">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7976640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="294" mass="33240" checksum="906ABCC52907A742" modified="2023-05-03" version="1">MERKQLDKKLSVLDAMHYIASAWDAVTPETIANSFRHCGFNRSGACSTSEAALPVDDEPEFGSLELPGSFADYVGADDDVAVCSEVSLDDIIETVRPDTAGTSDEEEMDDAAEASVSVPTYADVLCYVDHIRRRRIVLTGYPLQNNLLEYWCMVDFVRPSYLGTRSEFCNMFERPIQNGQCLDSTPKDRQLMRFRAHVLHSLLQGFVQRVTNPLKFFAVCCKVWNHPDILFHLVQDKKNEVGLDIDLDIDLIGPTVKETHAKKHHHHHHHHHHTNSAGQQATTLYVTEQHACQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEI4</accession>
    <name>A0A9D4QEI4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_004597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEI4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028668"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7975709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="390" mass="43398" checksum="30351ABA38093C51" modified="2023-05-03" version="1">MASWEYTLTGFGDFLEQRRLAFTQPMPASRVCSLCGRVPSGTALLPCGHVLCVQCQSEVFDGMECPFDGCAFTEGQLVRLRFELTDLEQLRVVCIVGGRKCATFSGKLSELRDHMRQCRSVDVQCAKCHRSIVSEAAVEHYRQCYTESAPRRLSSDLRVRRAVEEVRRIQEDLQVLRQQSLGEHVTGDDGFVNGANGLLEKLASLDCALSAVQEMEANVDHGDSPLSFRKAPGPFRAASKPGLFITTCKLPDMCAARDSLKGNIKESTVSSGSCTLAGYTFRADCKFSLSGNGEIEEVNVWFILYLFAGDWDEHVEWPFTKKAAIIIAHPTDESKDIRLIMPCMKGCKVTKKPSSNITNWGLMTETKSWKDIELQGFVVKDALYVNVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIA8</accession>
    <name>A0A9D4QIA8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIA8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028908"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050305"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="494" mass="55185" checksum="A6B2A8F9D63092C3" modified="2023-05-03" version="1">MDRERFFALGRELGLEKDALREWVDKECALAREERAREREEAKESAERQRLLQEQELKILELKLKLQESAVRQSTEANEPGGATSSVTTSTTLSRSVLSRKIENVPTVEGFMDKRPVTVLRDTGCDTVIVRQALVPKEKLTGAYRPVLFLDRTVRNLPEAVVFLDTPVFKGEVRAHCLRDSLYDVVLGNIKGALPLDTTRVMATRTPNRSSSADIEEKTPKTPRNRHSRRQDQVTVSHVVNRLRAPRPEPSDSSLSAANSDNHAACAKRWQATAPPSGSSQLSTSPWPNSRPDSTRYRGIRTPQDEALLPLDTTPRVPQRRRPRQHSYFEERNTGRLNQSRPGYPKLRSDGTDSLSAQMDQSPSSPQPPLQPPQDQVKTARQLDFHGVNRALCVLCLGACLFTRAGSVRAPRCDVYAAREPFPPCDFGATSINAASFDAYNFAPRPRVPSPSTNARPSYQSYDGYARRPPAVSQEWDGRAIHLSTDNISTSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIJ9</accession>
    <name>A0A9D4QIJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052408"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="233" mass="25821" checksum="F67CEA68747CA35F" modified="2023-05-03" version="1">MSTYSPPLKKRKIRQCTFRKEWRSQPEYESWLLPVDDDATAARCTICASTFTVKFDGVSAVKHHASTQKHKQKSLASKQSATIKKFFVPAISSAEGHVTAAELGTIFHGIKHHYSYLSMDCGSKLAPKVFSDSDIASRMRLGRTKMEHLVKDVLAPYAVECIVEKLRPAGRNLLFLLSTDTSNKGNRKLFPIAVRFYDVSGAGITDALIDFCEQADETSGGICELLATSLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJU8</accession>
    <name>A0A9D4QJU8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJU8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039325940" evidence="1">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="13047" checksum="FBE61A29C31CD1E7" modified="2023-05-03" version="1">MKTRRWLAIVAFCAFLSHVPVSLAHHVEEFSPNVTVPPTQRSPPQNLAAKIRHFAGNLAQSVPPWVKQRMLEAEISVECSLGLLKTLRGLSNLEPWALRTRGTRHMCLNAPSIKCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM52</accession>
    <name>A0A9D4SM52_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exoribonuclease Xrn1 D2/D3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002283">
        <property type="protein sequence ID" value="KAH7931473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM52"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051661"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="1">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="252" mass="28595" checksum="055002F7B7DF0EFC" modified="2023-05-03" version="1">MAIWGKLVQQFRSGIAMCLPLEPLFGFVKKLCSWHSLETHKHAKNYESVSIFKLASTDQEVFDMQVSGIKERYLGRYGVNVGEVDILVFCKTLTGRKYTCTSKGRITLDKQWAELSVPFALQSIVKDITEKSPDFEEFKTVEELFPVGKTCFMIGNPHYGCSGTNLCQVHYMNAHQMSQQLGVNAQFVSRITGTVYIQMNSREAESASLVNVGLHLKFNKTSEEIPGYSKRTNDTWLYSTKCLQVLKEYLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNN8</accession>
    <name>A0A9D4SNN8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_002946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNN8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049789"/>
    <dbReference type="OMA" id="GKSFCKA"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF12">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7938949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="644" mass="70368" checksum="6C4155F3E616CCCE" modified="2023-05-03" version="1">MLAAARPTPLGAMAQPSGAPSKARGCTDLPWLFALAALLGVAVFVASFALALGDPRRLVHGYDSFGNVCGARNAPIGSLALSGMDASDKPYLFYLDVADPRNSLKICVSQCPFRALHTMDEVRHFGEETGSTLCRYDVATNSQASALSNATVLDLFNKEQERTGLGPCPRLPLPPTKPVRNRCVPYDASSAILHSIYGYLNSADTLQQVVSDLFAAWRELCCMLSFACVLSFSVVYLLHRFAAVATKAVLIVSVLSVIAAAATLWWTYVDIKVHLDMTPFDRLLEESAKNERAFLVFAIAATLLATVLLALVLALHKQAGLALFHEAGHCIRHMPFLLVQPLWTLVALMALFATWTVVFLHLATANHASRETFPIAAFAPVAEVRHMTLVTYEQPSWVRFAWWFQLVFLLWAAEFVLACQQAVIAGAVASWYFCKDRTTLVWPVGRSAARLFIYHLGSVALGSLLTPVCRLPRLVVMALQHWTSGRPSGRCCRWLWCFSCVSHNAYTVVAIRGTSFCTAGRTAYLVLSESSPITSVLSGSCDFLLFMAKCLVTSAVGLLAVVLLRGNPQLQLCAVPVLAVSVFSYFVAHCVLSLYGMVVDTLVLCFSEDVLSWEPSHRDLYAPESLRRLLLGDTALLRPLPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNT4</accession>
    <name>A0A9D4SNT4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNT4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027247"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="285"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7936197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="360" mass="40529" checksum="FFA86607201E58A6" modified="2023-05-03" version="1">MGNGPPPPMPPFGPQAPPHYGMPPGYNHPPPPGYMHHGGPPHGQYGGMPPRGMHGFDHMNNDRPYYDDYDMNARSRQDYGNFYIDSESMPPRGDVVHHNAGPGLPDPRQPPPGCFPMNSQGYLPPELPPEALECLVPTMPYYELPAGLIVPLVKLDESDYRPLDPKDMRLPPPAPPSEALMQAVEMFYSPPSHERPRNSEGWEQLGLYEFFKAKSQHVRKRPSSDDEGDEYSRSRSDRDEQQAERRAKAKEAEDQIRDDIARRKYRESKSGSSYGGDPRDSRLDESNKGHQLLRKMGWGGAGLGAAEQGIQDPIHPGDVRDRQDLYKGVGINLHDPYENFRKSKGQAFINRMKARTEDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP72</accession>
    <name>A0A9D4SP72_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP72"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12547" checksum="33978644B8CFA88F" modified="2023-05-03" version="1">MSSPGQDIVPGGYLALTNGWVKNIRGAALTERRVNEYLQSSGTRCERQLDKGRRFQEEGYVRNIMYNEVSPRSEVGVLRSICLPSMKGGYYLVHAALRKDTGAVTGAHCLCPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPC3</accession>
    <name>A0A9D4SPC3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_016133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPC3"/>
    <dbReference type="OrthoDB" id="6512761at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038868128" evidence="3">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="326" mass="34494" checksum="B6B9EFB4B68571D8" modified="2023-05-03" version="1">MLSFNDAILSLVGCTLCALAVTVSSYPSSPVYGRLQRNAASYAEGRYAHSDPNYYALLRSDVPLGAPASSPDWGQFLPAPWTGGVDAYAAPSVVVPPVVPQYDDYADEYDSSATGIQFPAGASPNLGGYDWYEAQAQAEQQQQQEAQLEQQEMQEAAVFKDLLANYLSKKSSDSAAPARDSEKRSETAKKYTVASVGARAKSTTAKPNVAVLTAPRDKGAAAAAVARAPSLSVTSSPVPPPTGSSSSVVATSGAHTVPVSQEGGQKEYAMFRPVGTAESRRPTFWRGGAKQAKEEAAATHAKVTRSRFGRFADDSLTEELDQLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPI9</accession>
    <name>A0A9D4SPI9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPI9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037481"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7936405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29988" checksum="96F368E57BA7EFE9" modified="2023-05-03" version="1">MSRNRKPLTLGEKLHIIEEAEKRNGATKASIARNLNIPESPLKTILAKKDSILLNAAKFGLNRKAAKDGKYAAMEKALVDQLQPLDAGVIKCMKQKYRKFLVQRRLAGMERKQLDKKLSVLDAMHYIASAWNTSTPETIANSFRHCGFNRSGACSTSEAAVPVDDEPEFGSLELPGSFADYVGADDDVAVCSEVSLDDIIETVRPDTAGTSDEEEMDDAAEASVSVPTYADVLCYVVHIQRFPCARDDIGDLLPDCHFKPTLNPTSAITSVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSU9</accession>
    <name>A0A9D4SSU9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSU9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18386" checksum="36F743A85FA45245" modified="2023-05-03" version="1">MAEHYIDIHATVPQRHALTKCTPMSLQKLQCGDRGRNSGAELWVVQKAHDDELPSADVAFDDLRAGGVLIPAEITLEGFADADKDLELCAELTDDEIIHQVTEDSDADTENEEPAPTQPTNTELMRALMTLSLVYSGNMTLTEIEADIIAGKWTVQKKISDFFAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STU9</accession>
    <name>A0A9D4STU9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_007409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STU9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052227"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7947012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="540" mass="59627" checksum="6E7A21DF9AE6DB88" modified="2023-05-03" version="1">MPLTVGQVIDRAADTKGDTMAVVSCHQGISKTYTQFKRDVDHLAAALVSLGLPPGAMIGIVASNMYEWPVVQFAAAKAGLVLVNVNTLYQVQELEYCLKLVECEALIISEKFARQEYYDMMLQITPELERCKPGELKCARLPRLKHVILLGDEAKPGTLRYDDLLAQTTRKDYAAAEKIASQIGFDAPVNVQFTSGTTGKPKGALLSHFNVVNNANSMGRGLGFHEQHEIICLNVPMIHCFGCVIGTMAAVVFGSTVVMPSPVFNAFAGLQAVTDHRCTVLYGTPTMYIEIMKHLSSDYDVSSLRKGAMGGSPCPPEVIKNSIERLNTKTVHVPYGATECSPVITTATFDASYDKWVNSVGKALDHVEVKVVDSENNIVPVGTPGELCARGYLVFLGYQNDPVMTEEVVRDKWYHTGDEAIMTEDGHVIISGRISDMICRGGENIYPLEVEEFLYTHPDVEEVQVVGVPDKKFGEEICAWVVVKAGRDLSERDLKMFCDGQISRFKTPKYVFFVDSFPKTVSGKIQKFKIREESRKKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV00</accession>
    <name>A0A9D4SV00_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_019888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV00"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027669"/>
    <dbReference type="OMA" id="TLGGPHV"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7948253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="403" mass="43720" checksum="28624D4B2D437D6D" modified="2023-05-03" version="1">MVLESTIICVDDSEYMRNGDFIPNRLQAQQDAVGVVCQSKTQSNPENNVGLLTMAGPQVLNTLTTDVAHLLSKLHEVRPNGSINFITGVRIAHLVLKHRQGKHHRMRIVVFVGSPIETEAKDLLTLAKSLKKEKVSVDVVNFGEADANTAKLESFINTLNGEEGTGSHLVTVPSGRDTQLSDALVSSPVVQGEDGVGVAPSGSGGFEFGIDPNEDPELLMALRVSMEEQRQRQEEQARRAAADGAPNDASQNASPMVNEVPATSSDERLLLDRALAMSMETDPAPATAKSPSSDAFPDITAMTEEEQIAYALQMSMQQAKSSEDMVTELPAAAAPPEGKTEEPKKEEQKEEEEAEKKEEKKEEVEKKEEKKEEEKKQGGTEETGEAGNKEETAKKGKSEEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV22</accession>
    <name>A0A9D4SV22_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037224"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045852"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7948257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="316" mass="35572" checksum="4780B882856329B3" modified="2023-05-03" version="1">MDGLHLPLANNGGNGHFTFTYQPEPEFKQFPEVERAVDPGEPAIEIKGNHFELFMDHEVVLVRVNGLDDTCNVTNVVHAGQSYPIGAVKLMAAEQPDPDYDVITATAVAAVLAVALSGDSRGGEVDSKAFLEEALIMKDFHHVNVLPLIGLSIDKTDGLMVIIPYMKYGDLLSYIRDERNKPTVKQLIIFGVHVAEGMKYLADTKFVHRDLAARNCMLSEDFIVRVADFGLSRDVYEKDYYSGDNKAKLPVKWMAPESLEKGIYNHKTDVWSYGVLLWELITRGVTPYPEVDNWDIVDYLRQGRRMKQPSYCPDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW90</accession>
    <name>A0A9D4SW90_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW90"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032220"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="29556" checksum="178BE91C6A803DAF" modified="2023-05-03" version="1">MTTTYLPRLRLLRPHVRPPAHQFLRPTTRPTRYRKCLLPSATPLRAVFSTASAHGPLDVPAICTSSPTSMAHDTSATSGSMTATSPHALESSIDRDIVMAAIRPPIAEASPAMMPDETVFPSTSTMCASCQQRPASPSQSIAAEVPAPNHRWPNFRDAATMTDAPEDDVPGQHTPELTAYATPATEANIQHVDLRTSPREPTTVGASTSTGSPSEPAAETTPAQLHHRFPAEPLTQDTIHPTSDRYVGALVATATTPNHHTCLPHATLRRRSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWE8</accession>
    <name>A0A9D4SWE8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036368"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056706"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="100"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="31678" checksum="EA5FB7B43321004D" modified="2023-05-03" version="1">MAGHKRGPRFKDPDEPRRQNSRVSVLDRARIVDVYRRGGDLKQLAQALGINIKTARSIAATDRQTLLRDRNRDDVKHSHKLYAQWLQSDGPRTNYNTWCSRNFGRAAKGQPAVHTTTTTRGANLDIMACMSANSVIHWTAVDRVHWAVFNDFLSDVSARVESEEPNTEAVFIFDGAPAHARAEQAALANSMHSVKRLPAYSSFFNPIEVFLKFNAHVMAYLSERPDLVLATPQGMTKKEHRPSLLLDAAWHSMQQIQHVDCAAFDQNNFSFVPAALREDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX87</accession>
    <name>A0A9D4SX87_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX87"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040381"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="113" mass="12848" checksum="ED627B8CF34E5060" modified="2023-05-03" version="1">MVGNLRPHLTSTSFGVEFVPVLRHAADKPEEAHHYVVEVWVRGVYRVVYTTSDGDCYLREGDMSYQAGTHDVRAWIVRVEEEYYLQAKNRANLKEGDSPAADDAPRPWNDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY80</accession>
    <name>A0A9D4SY80_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol kinase accessory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY80"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039096"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Diacylglycerol kinase accessory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20890" checksum="C231531BD89FF787" modified="2023-05-03" version="1">MYMTNYFSVGVDALVTLNFHKTRQSWLYFWKHRLFNKFLYITYGTRDLLEKKCRDLPQKVRLWLDGEPKDLEHLEAITVLNIPCWGAGVRPWHMGAGGQLAQPQRYNDGLVEVIGLYSSFHVAQLQVGISEPVRLGQAKEVKLELLERLPVQVDGEPWEQAPATLCITFHCQAAVLVNQGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYA3</accession>
    <name>A0A9D4SYA3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYA3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048709"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="62748" checksum="7555D98C9CADD9C6" modified="2023-05-03" version="1">MAAPNQVTGYDPESLRIVSMDTAQTEATMPTEEEYLQDMLRVWRGKKNSAVASRDAGALAARQHTASRSQHAQGKSAPSVASQHIKQLQWRPKNTPRIEKDDIIVVLKPRETLDIKATFGPGQAGAAVRSILGADASVGLAVWPIWDQNVLVCTLKSVDAAEKLLRDITLPVGGRQLPFRGHPKLSGEFCRGVVHVSQDETSETVKSKLSAEPNVTVRKLGDTTVAVITFAGTKVPRTVLYNCERLPVHLYKKTVPACPLCGTVGHRADTCPRPQPGRCISCGVQVPAATPDGPTEHQCVPSCLLCGGGHKTGAPGCAGRFRKPIKSGSPRGSKPKTAGGHKQPPMPKTSPKKAPAAKSNKPEPKKAHTGPSTNAKPGTPSKPPVLMVKDFPPLTPVQAQQQIEELRRQNRFLARKIQELEAKQVGSSEPEQGAEVEDGDDGSSVTSDLTSVSRRDADTVVGSVSATGATGRLESLERKTEQLEERMAALPDQIMSAVRASFQDMFTAALTQALPEIMAQVSDSVLKAVQPWVSTQIKNTTQCDSPQLKRKTASRQAVDEDFSGLAPGGPVRPPIAAAPAPGPGRSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYJ1</accession>
    <name>A0A9D4SYJ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_010069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYJ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041533"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="574"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="781"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7956479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="863" mass="92136" checksum="2F01D9D74DFC2254" modified="2023-05-03" version="1">MWSGENLTSDFSVSSFGLAVPQLVEGSHPQPQQQELEPPGSDHDVNCGMLGLYPSFLQSYRTHLCYLMCLCVLGMTQGFVVNGLVSVVTPTIEKRFQLLGIEMIQSMFNVASCIMTTPVSYHGGVGHKPVIMGIGALIVATGSMVFASPHFLAPPYISLDSGSTDVCPQRGLGKCAALARSGATSANSFKYFFMVGHALHGVGSSPFFTLGVAYLDQNTPSASASIYMGIFYATSVLGPAMGFILGGYFLSKYTDITADSSKLSMDPSSANWVGAWWLGFFCASIVTFLTAFPIASFPRALPTAAQRAKDLSKLQKKKAMKSLKQAPSEADVQAAPEVQAIPDAQATTQASKARLTARGTKTTVVTQASPGIQPTRTAQATRGNQVTLGIQATPGSQGAVGGQGAADHDAPQDMQIASETTVGKTHTRSLVNHIRRLTCNPTFVCLTFAACAETMIASGLTGFATKIFISMFGISSSQASTLLARQTARPLTRSALRMRTAGIVSVPSACGGTLLGGYAITKLNLKSSTIVRYCVVLSFVPWFTLFVFMHSCPSSHSALVNITSWSDDRTLTFRDLRHSCNAYCNCSGVGYDPVCGSDNFTYYSPCVAGCGHVRNFRKTKLYAQCTCVHGPNLFLDSEGEGNETGYYYMARRDPCAADCGLIVVYAAAIFIALFFTFLLIVPALTALLRALDEDIKSTGIGVNYVAIRILGTIPGPILFGHLIDRSCVLWEGTCSGGSGACAIYENSAMGMNLFRIMLSVKSASIVFFFCASISIKTQSLSSSVPTGRTPEAQEADDDGQCKKQGNGGTANVDNDVMDKGRVDVGDEVKWAEHDEPSGQASSEERLIPPREKEKKENRKKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0E4</accession>
    <name>A0A9D4T0E4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0E4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026549"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035687"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040573"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87694" checksum="F6F01403BE75E046" modified="2023-05-03" version="1">MAMANSDQLRKKRSALRTGVTRALTQLTDLLQQTDPNISEVSVQLDYLKDRESTLSRLDDAILAVTEEDDLDREVETTQDYSDKISYALARAKYWLQERHQATRTHAQASGFGSSNLELPNSVDAPGQTPEDRIRRAKDLLTFLRIQVEVREEGRLQLRRRPHESEKMSMATESTGGAEHIPSAAALTSSAVSVNQVCPLCNSSGHSIVSCNATLSADDKLCKKSYSLTCGTCRRHHLTILCELSRPVEGLPPTAESVALGRPPLPSLRTVTTAQSTHIGSTVVLLQTGRIWAECGNRRLLARVLLDSGSQRSYIREDAARKHQCSVVGREELSLITFGNSKSQRRLRAERVSVRLRSQFDDAAVELEALTIPEICSVTSPPLENNILQALIAKEYKAFPSETRIIQFTKPSPAAGRWKRVRQQASMSTLILAARVVVIGGRMGVTPHLRNFSQIGYFLCEHHDEDRIFEILHAEYIVIKHLKDALNAIRVGPKDGKGCDSRKSMTAVNRHFRNQSELLAGIRPAQERFERTAQKERKGRNSSFNGDVNEMEYKAQLNGLGYVPLFELLPISGEDTSLLSLEESHEGSKLLVSTLGLEGTCMEPLQQSLPRTTLTEPGSCQVLPNMNCEIGMDTNVVHVYENNENAVAERAMNFSYVSLPQLINDLNNIGLMITDRPLKSSRCHWLSWKSIRLRRRLESKLDELQQLISSQFLLGSRHISVPQRASASGLANALPLQRKARHRQRLSTELRKRRQRAYLFLLRPRYHRSSCTMDAYYTEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1F0</accession>
    <name>A0A9D4T1F0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1F0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="264" mass="30295" checksum="E8A0C85550488E46" modified="2023-05-03" version="1">MIYFSYQGVDQWAERCKLMPLQVALQHLYPALKACSKRCSLGHLVDVLKEQGRLDVLNKISQQIKGISNPDNVRSSLNNDERIQEEESMCGSLIDKILPKTKLDKLTVLVSHLEEDIDLAQELAKTLETEYECYVLTQAEIQPALHTDPTLIEDLIQKVKAIVPLITRAYLDHYEHSRRTTDLNSADSVLTREVYSLSLHRLVSSSCLYYMLFPVRTPDVKYEEVRRHHIFSKSKVLCKKDLALLVKTMHACRKLRISNERGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1F5</accession>
    <name>A0A9D4T1F5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1F5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="495" mass="55948" checksum="210906D86EDCCC78" modified="2023-05-03" version="1">MAESHMSEVSSAVESGVGHAGGAGSANEEDADRRRTFIAICCLLILLILLLLLLSGFVFSSGSEEDDGAGKTDPAVYVNPGGNGPPSSGGSTTKATSAQTSPATPPTTTEDSWSYSQDYTQAIWTYLHYYLCPFWADKQGFRSHRRTYGIAFFPYMFCHYAMYCCYSLDDNMQLQPELPHVDLPPRDAVRRMANFKAENPYLKVWLVVRGDDSVFMKLLANANNEMATFQNNAIAWMKSNNYDAIRMWWLNAPDALNRSMALLYNETNDVFMPLNYTFGFLFPYDYYERAPYNTSKLAHRHAYHTIVMYHDYPRKITNRTKATTYAIRELKVYSQKLNETDRPTFCHLYPFAALTYKIDPAKCENSSVNSRFKPYTIHPLGYGPPGPLTKTAGMLSLPEACDMLDSTWNQTSIQADQANIYPNYHFACKGEDVIAFTDGDDVYYNLVALDQEYEEEVFGVMNPEYDDFPGVCTPPVGDNDSFPTVRNAFQIMYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1M3</accession>
    <name>A0A9D4T1M3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1M3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057205"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="255" mass="29286" checksum="17A1EA2AE1D3E57C" modified="2023-05-03" version="1">MRWGSIRRTFAGLLEGRLPGYLWYLPQSLTLRHPYLLRVLTENAHRLTTPLDVHATLRGVLEDFKLLDAPSTQPFVRETLRKYDGIRMASLFTPVRLNRTCDDTGMEKQWCSCLRRTAISTSQRPVPQVAEAVVHYINRILQPYAPRCARLILQRVDTAYAHTIEDPKDSVSYKPRWFEGFFLFGHRRDVREYTVSLVTIPGEAVFEATARVFDGAVTVMGEVLRISLYGNSSHCVPTMPYRKFCYCLQPASPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1Y5</accession>
    <name>A0A9D4T1Y5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_009098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1Y5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052817"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="418"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7968505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="851" mass="90074" checksum="8D7882945B719654" modified="2023-05-03" version="1">MDPSAAKGNQPSREAKKVPPSLSGSSSDRGRETSSSSSDNLSSTGTSPTQRHGSPQSGRGRGTPAARAEGAAPQSAKVTARAAHRSPSSGSRVAFQVLGPEDLVAASRECLEGVLDELNISTLAATGRGSPDSETGALKASPSKTSLGHLDHRVCFGVTSVSEEKLSTSRMASPSTGATDAKYSGVRTPPKERPMTDEFDISVTEEVDFMLDEDDDSLDPEARARRRRSSAASGTSAISDELDAPIFAGRVKPPLGLLSATSTPPAEDQLAAAASQKVAGTKQDAAGARCNTGGSSVDEGKGSTLASPRREQLHSQGQGVHGSGSELHNERSVKTVLGIPEVKPELSTSLQRVDSAHDLLSSPVIGSISTEEGGASRGVRSIGSEEPGREMFSSRFTQSLSAVLRSAIVIATSRRFYMLAIYSATSLVNGFQWIEYAIIASVVQEYYGVSEVAVAWTSLVYHIGCVTLALPSSWILENMGLRVSVILGALGTSIGSCVKIFSVHPDRFVYVLVGQTFPAFSLAFIVGVPSRLASAWFKYEEVSTACSIGVLGSQVGIALGFFVPPYIVDPKNVQATLMTLCVIVAVASVACLLVTILAFEDKPENPPSFPEMLNRYAEKKPTFAEALCRLMKDRDFCLLLLSYGINTGAFYSISTLLNPVVMRYFPGEENFAGLLGVIIVVSGLLGSWAAGWVLDKTGKYKEVSVVTYAFSTLGLLVYTFVLSLRSRWLTGTACFFLGFFLAGYIPVGLQLGAEITYPLPEGTSACVLNMASESFGFVLILSSTNVLRKYGDRVSNLALSGMLLVGCICIVNLRAKLKRQLATLRVQRKRSASACGGLRASLRSPALAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2J8</accession>
    <name>A0A9D4T2J8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2J8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7967799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="448" mass="48906" checksum="C536A0019EF68AF9" modified="2023-05-03" version="1">MASLKQNGRRRGFSEGRFQATDWLSRGALFKRAFPSLPLAGATDTFFHAIEMPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSAECQTGDAGTDFLLVDMKVLNNFFAQAKCDKCDAKSLSVRKATDKEYGLAPQDEGYTDWLATHECQRNIECNSGRMEVEAALTMFQRSWAKHGLRYTTVLSDGDSRTFHALSEAEVYGFIQIDKKDCINHVHKRMGAALRNLVDKKKAQGESLGGRGKLTQEKIKKIANYYGYALRSNINDVPAMKRAPVFARLSDESLLARCCEGKTQNASESLHSVIWTQTSKNGNASLESVKRAAAEAVAIYNQGRRATNESIAANAPWISAANPNYIRTAAVAVSAAASPSRPDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T353</accession>
    <name>A0A9D4T353_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_021718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T353"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052615"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="302" mass="34497" checksum="5CEAD55A4D9B5B76" modified="2023-05-03" version="1">MAASKASTGRLYFSIAYDLALLREVNAHNPFQDPSRWEGIVKNMNFALGKVFSARALRERLDLLLAQFIANDRASLRKSGTEEEYEEKERLLQEICSLAKDFGYKVKSRKAQSSAEPLSADASCDDASQSAADLLERIVQGTDIAATPGPSDETTTTANNPRQEASTNADDRPDTEGAAQVVPRRRRAQAATASADYEFIEKRWKHERALKEKEHALEMERLAVEKLRIERKQQRSEKRHALKRERTERELQLREREMEIRERQLQAQLDEASQREQLSRFHKATQDAILKIVETICEKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3T2</accession>
    <name>A0A9D4T3T2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3T2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038433009" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7971941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="185" mass="20382" checksum="A9FC350977A54EBF" modified="2023-05-03" version="1">MIISIIETKVAILVQSLLTAIAEPEQTAVVESRLKALVQAKLEPITAQTGDTFTTLSRRIDTGTAIINELKSRLTNFMARVKNNCITHGDFNAAHTAWGYVITAKKGSRVHDAAQQHGLTLWNDPLQPTRVGKSVARGTNPDHTFTREVKKAGSTCLPDMFGSDHHIIQLDILYEHRPTETGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4M8</accession>
    <name>A0A9D4T4M8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4M8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039362"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="108" mass="11453" checksum="60032649AD2743A6" modified="2023-05-03" version="1">MFLKTIGSSNASLLLILVFAFVITYSIGYLFMRRPDMTCGSESASSCPAGSEQRTKESSSSANGPTSSSGGRKDETTPLLEGSGDEDDEEEEDEHSSSESAANEKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5S4</accession>
    <name>A0A9D4T5S4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_006854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5S4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040043"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7975956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="317" mass="34495" checksum="6E85E67BB377E8F1" modified="2023-05-03" version="1">MADLRRVHRFRDHPIAGVNWRPTRFVDELPSSRVCGLCRMIPTRTVLLPCSHILCQSCTAASTQDGRRLCPLDQEPFEEAECSSYDLPVSTANALKVYCWNEAFGCEYEGAMEEMLQHFEKECAFHAVECLQCGEAVLHSALATHYVAGCSVCVSSVRRDNTSSESGAVTIEDVRNALEGVSLLRESNLDQVLPAIQSQVTELTEQVGNQETSLAEVTGEARSSLNAEVGEHAATASSTVLQESASCQNAAVEASTSTSSQSCTQELMNPKPEMISDLSPRVLQQMQKTSTQDFPQHFIEYDGLPEVAGDAGPSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6Q3</accession>
    <name>A0A9D4T6Q3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_000600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6Q3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046031"/>
    <dbReference type="OMA" id="MRDESWP"/>
    <dbReference type="OrthoDB" id="6418345at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000231">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF31">
        <property type="entry name" value="ZINC FINGER PROTEIN PLAGL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7975339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="29484" checksum="DE5D79CDBDDF6BD3" modified="2023-05-03" version="1">MKVESWPAGGRQYRCPTTGCGRLFSSKFKLLRHALIHGGERPFQCPSCERRFHRKDHLKTHQQVHDPNKALHTCALCGKKYSSALSFRKHSALHAAEAGDPVCRLCGAAFARREDVLLHLKVHSGASSRLVKPPTERRFKCDRCERSFFTRKDVKRHLVVHTGQRNFQCQFCPQKFGRKDHLVRHTKKTHHGQAAAAPWATAFAPSTTAMSVVSAATMAEEPPHHHRPPPPPANPTLLLTGGYCGGPSIVAAPPPPLPHFSQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6Z7</accession>
    <name>A0A9D4T6Z7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_004054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6Z7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041139"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7975669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="257" mass="28964" checksum="D7348360F939D978" modified="2023-05-03" version="1">MFMVTVMKDKQTWKSKGVAFVLFVDPESASKCASALNNQPLMGRTLRASIAKYNGRAPEFIRRKEYKDKSRPKEQEAEATESENEEDPALESLHAAIKYEQQQRERESGSGQQSGAQSSSGSRRRIRKSAYFSDEEESDEGNGHQIQQYTNQLAKDTNGQLKALAAMPYGEQGAGRLLREKLTNDFSEALHHFQLVQRAEADKEKDSVKRARAASGIGQVNIEMLREREQAIRKLEVRGTHLETNVMLGCLDREISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T807</accession>
    <name>A0A9D4T807_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T807"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="260" mass="29645" checksum="D3A14F2FE5CE0A4E" modified="2023-05-03" version="1">MDDLNTDSVDTEDTDVLELYRKGLEDYRDLEDNKSERRADETRAVALAYEKISEAEAAILWRLLRSRRVEELYLYDISLWAFKLAFDNLEQCPSLSSMYIHVDLQGKEFGTSFSGVFTSLHSLELSCDNTGSGFAYHIASYIRQNKTLRELRLRNSCGGDEGAAVLIEALLENDTLKIFALNNIKSSSDTLVGFAKMLATNRTLEMVHLGEMWCSKMRVHPILKQTQGSVLHLLELHQLFHWTLCQMLRQPSDEGSLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8Z1</accession>
    <name>A0A9D4T8Z1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8Z1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15339" checksum="F1104B16DD9FDBE5" modified="2023-05-03" version="1">MKWLKKGAQNNRVTSSISKCLSAQGRKAKTAAPVCAFVIVSSRFPCLHGPPLLTRASGCMRPPRCLAHHSRYPTPKATAQARLYLDVTLRRNRHRLHEQATVIHNGGADGAHPTAHECVCVGAAQPLYGRRHLPAARKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9C1</accession>
    <name>A0A9D4T9C1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Paf1 complex subunit Cdc73 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9C1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033407"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9886" checksum="7A2DA1AEEDE03FF1" modified="2023-05-03" version="1">MAGLDASMRNFAKSIFPILQSIKMREEGITTKQAQPEANQPPRATPVRAMPQPAVYNRYDQERFRGKEANHSSHLSYIAAALAASRVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBV0</accession>
    <name>A0A9D4TBV0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050909"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="268" mass="30576" checksum="D26B3C8800D4F87D" modified="2023-05-03" version="1">MSRLRGSGCRKHNESKCRFMAMNRFGQELKMIADRNGKHKKCKKDLRKAHDGTAQFTSPNVHNGEYSLRGHMELLGYNLLMWSGCRLYWQDNLKKPDYVSQQKSKLLENIPLLMSKCFQHRDIPCGITQFLQYTACMKFEKTPNCRLLKRISEKGIQSVGFKPGSRLRCAPPRTPRRNSYSPKKPALQEIIFADGSMDKNGNENVVEKLEPERKPLKKKVVSSLSGRTSCKDSQKDGFCEDSNSMGLDNPTLATLEVLQCKQAVLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC76</accession>
    <name>A0A9D4TC76_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC76"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027603"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053004">
        <property type="entry name" value="MAGUK_Signaling_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360:SF1">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="393" mass="43570" checksum="52173A469793D7E0" modified="2023-05-03" version="1">MHTPVCNRVCACSRLLLLRGQRRAHMCPSRYRKDAAVPTLLDKAYNKIFGESGSPRRRRPCCLTKGPIEELDSMLECYSKTGGKRSSGRQHRNIMGAHGPTRRGRSGQHTPTSQATGAQSPKGSHGVQQSSERVPLHYAAGLPEDRLDYSVVSAHKDVLEMYQHRGGLKSRPHSAHYPREAYAKPVTPYADVLLSGHVHQSLRANVPLYPQPRGHQHAYYPIHFTLDFPQQFQPVAPAPKRLVPTHVHGPFRPEETYPQPSYDGLATFPKRNHAYGSHQHQVSLQSHRRKVSTSSIEKAPSLTDRSSPMPAFTVELLTPNGSRAITELRGRRRPKPGDMRRIVIEKSLEPLGIQIKCGAGGTIFVSSVSENSIAAQASLQVGDQLLEVSEQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCQ5</accession>
    <name>A0A9D4TCQ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_025631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000921">
        <property type="protein sequence ID" value="KAH7985439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCQ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034931"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042311"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="521"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7985439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1157" mass="127366" checksum="1ED42C74D607E993" modified="2023-05-03" version="1">MEVAVEGHTITAEEFQADHWTPVLYKAYASRPASSPKPLPYPNATFEAANPNARNAAHDAAAATGSGTTPARLPPATKETRITVKRSKQLPALPPNAIRVVVRPRGELRLRDIPTPRLTKAVQAELQITLPDDFCLRIHPTNNTFTAATTHSSTAEILKTLTSLTIGDHTYPCVAYVAAPPGATRGVISNAFDDETPTQLYQDLVRRNPEYTILAARRMGKTQSILITFDANEVPHSIKYMGAIHRCTPYRGSPDACTNCRQPGHRYDVCPNPKSNLCPRCGTHLPQEPPCTPKCILCEGSHLTGTGSCKGRNLHQPRKQTKQPETQQQEPVVHGDNFPQLSSGPIQPTQPSQHKQAWTGPLNKDWGPSRSSSKHASFLTATPTLQDALAKSREEAAAAKAEAQAARAEAAALREHIAKLEAQISTLATSYPNPPTPAPTASQPPPPNPPTAPIIANHVNSTSSPHALDWKVAIGLGIIYGVVWILVNPLSQLAFPYCDHPKKCFNYAEELAASLDRRINPCDNMYEHVCGKWDRLHPYPMPGAGGQFRVLQYRILSFLITKLEQSPPNHPVVAVRRSVSAFQNCLNVYEERRDDTKVVLDIFRKYNFEWPSMSLPADFDLLEYLLGMSLEYGFATPVVLGLTADLKTDKRYGLSLEIEAATDMEASMAATRYVKHCITHVAPSVTSDLASAFAERIQKAANDMVTAASAIIPGPRTNQNYTTMAKLVNDVAGHGTVDEWLKVINGHMLPGRTVDMTEPVLTINGSGLLLKAVLDNAKRSSYVDLVLHTGWMTFYNMRAVVSASLLDCTDGGGIQSQIQSATQCLENMAQVSTYALVRLIVDSLDLQPQVNDTLRTWMAVKEATRANFPKLPWMDQSTAAGAIHHVDSLITVLTMPEHLKSDEALEKFYVFLDQNVTQPFVVWLYNTYQRRLQEQKRLMKEDPAVPVHREDIVFSPSDVNAFYAPLLHLMVILPGIMNAPFVPSTEPPAVVTGGVGKLLGHELSHAFDPRFSTLTRTGDKITWWSKDSFAKFLGRLDCVTSLLTNYTSDAVFAKNVLTETFADTAGTEKARLAFGSMELTDGILGYTPEQSFYVASCFLFCSEGAYTWKKTGLYPPMMLRCNLPVHNQERFAEAFSCPVGAALNPQDRCTFHVANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCX5</accession>
    <name>A0A9D4TCX5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_025543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000827">
        <property type="protein sequence ID" value="KAH7985589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCX5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040254"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="10" id="KW-1053">Target membrane</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7985589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="311" mass="32902" checksum="FBB4BBAB5EDE3523" modified="2023-05-03" version="1">MEESRRALEELFSLLKCVQCEDLLQEPHIVGLCGHTVCRRCIGRRDACGVCGSPTTQRELKPDPQISSVLTCAAKLGQLLSSSTLSETAPGGDDLQDAAQTSDGKIIQQQSVPKADFLHLSAVHQKTQMLCTFATTRKVAERRNRLGETPLQVAAIKGDAARVKALLSGGANPNVRDNAGWTPLHEASSQGAVEVVRLLLAAGASVNAAGPDGVTPLHDAVLSNVPDVVLQLCSAGADINARTNDGRTPVSLAQSELMKAALRSPAAPGLQQPPRPPQAQGKVRLRKNCYNEQTDKVAALYGDRGVAKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPH9</accession>
    <name>A0A9D4YPH9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_012532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPH9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031806"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7983547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="394" mass="42869" checksum="284DB2B3BBD7D017" modified="2023-05-03" version="1">MAQPTGFESNELHGEGETTPRDGATPRRASSSDSEATIVESLLTTLDISTMAAATKKQLVDELRVRGLRCSGRKDELIARLIRDNTTRQALEPTDSSTNDQAADDDDRQAHLETLSADNARLRAELNSLRAQLNCATTSEQRETSYNASHNASLPTKRVTTPTHGPCHSVPADTTIPSGSTQSSPLNEGTNQDAERPAAPTVSTHGGEPSMAQILAALVNTQALLANSLSRGPPTTSPIQIHSTSDTSSSIPTFDGTPHQIAHEWMRKWRESQRLAHWTPSLTLVTAASRLTGSAKDWHSAYGSQHDTWEQCRRTRSLSSASNEATMHGFLELQTKATPSGGTRPSSSTCTQRTHSQTWRLYRLAEEDTKFPYSQSAIEERHMGQPLQHNSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR18</accession>
    <name>A0A9D4YR18_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR18"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029027"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057776"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="163" mass="17787" checksum="CA3F3906E7231EB9" modified="2023-05-03" version="1">MSANPPKRARQPNFTQGELAALVDCYEEYFRAIESRAAVVRRSRATTGGGPEDVAPLDDIQARVANTLDPEAVFGVSGGLDIGAPSAVEQQPDGEVTAELFRAGEISANNDRSIMRDGGKTTAPRFVYTAEERELLRNLVMRHRSVIENIRTDDVSKRAKDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB44</accession>
    <name>A0A9D4PB44_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB44"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="319" mass="33569" checksum="84E9A8B27234A159" modified="2023-05-03" version="1">MAPPPDVASGGTMAASKSASVERSGSGDDDDTASAVSWASVDDTVARESAVEGGPGDGKEDRSAACKGSQGERKLGLKGKTGPAGSTAAQSAWWNKKGDDDASHGRDVLQSANDKHPNSSVEQEKSVKAPGGEDAPKQPKLSIPIRATIWRRLAAARPGGSSTWRQHSEAGRKPSREDKVATAAVEAQKTTATSSSDELEPGELVIDERSPKPPDSLRHTQHQPLSMPAGVGRGRNSRRRDSEAAHGGILSQSLTPSGPGAHKADGGRPQRSTKLVRRDVTGRLRGHMARSEHEEATSKQHSSKKPVANDMDTDSDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB56</accession>
    <name>A0A9D4PB56_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_002667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031253"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7935022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="395" mass="44738" checksum="7C1A6F701B01E378" modified="2023-05-03" version="1">MTAFLKETSERYPGFTKLYSIGKSVEGRDLWVLLVTKDPDNEILLKPNVKYVANMHGDEAVGRQMMVYLISHLLTQYNLDPYVRHLVDNTRIHIMPSMNPDGYAVAKEGTCKDLNGRNNARGVDLNRNFPNIYHTQKEQQQPETASVRRWSREIPFVLAGTLHGGVLVASYPYDHAKFFVPELETEAQASLTPDNDVFRHLAEVYSFNHARMHLGAPCFTNGQRFDNGTTNGATWYFFEGSMADYNYIHEGCLDVTLEISCCKFPRRSELAGMWEENRQPLLAYLGEVHKGELSVPLPPILSIGVRGIIKDDNGVPVTHASLRIADRRSNFKTSSRGEYWRILRPGNYTLEVTAPGFQEAREHFSVSEEKVTILNVTLKALHKESTNDIVQDTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBE8</accession>
    <name>A0A9D4PBE8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001825">
        <property type="protein sequence ID" value="KAH7931979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBE8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029925"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7931979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="315" mass="34824" checksum="3F0994E008FECB66" modified="2023-05-03" version="1">MREPSVKEVSSDSVNHSQSLNRPPVDSWALCKCDGEVVAAHCIRAWPGTAMRAPMSRHCFFYVEYGVRVRQERSCTDSANSWLPTHIRKLDVRPSIAEMDFASSTMKKRRLGADASAARYQSTSEDTGNTVIPPLRYLVRLTGRSEPESPEPRASVADPNASSARPPLRLGMATGTLDAFETTTSSHGEPTPAENMDLTGPGSSTMDGRHDGIADTSRQNIEGRPRTDDDWHTVLTLRQKKQQARERKRGTDATASTSPTKPYQRRRRTPKLPPLPKEDFKIVVRPHQGLPLKTISTPALAEAIVTACNKEIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBF8</accession>
    <name>A0A9D4PBF8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBF8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041917"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="11504" checksum="2EEE2F1FA50F04BE" modified="2023-05-03" version="1">MAAAPTGGYASPPQFDETSDKWPAYQVRLEAFFEGNGITEDKKRALLVTALSTHTVDVLSGRCAPDKDVGATVLRMREAPRTCVPGSLGPCVRAAINNAATTGLLVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBZ4</accession>
    <name>A0A9D4PBZ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049006"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7935468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="116" mass="13383" checksum="58D94018D37C1168" modified="2023-05-03" version="1">MPKQAYDYFLVLDFEATCSAEKGVPTPQEIIEFPVLKVNGRTFATESTFHTYVQPQAHPQLTAFCTELTGIVQDMVDDQPHLHQVLSRFDDWMREQGLLQARTVFVTFGDWDLQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBZ9</accession>
    <name>A0A9D4PBZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_000058</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027550"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000882">
        <property type="entry name" value="Predicted gene, 21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000367">
        <property type="entry name" value="Zinc finger protein 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7934768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="290" mass="32772" checksum="BF45DCF14F8613D9" modified="2023-05-03" version="1">MARDLKNTRTRQQQHCTNDAGGGGGSCDDVTRCPASESASQAKPKRKYADVKHHKCGVCGNDFSCKSSLKRHLATHAGKNQHACPCCPATFARKSARDRHLLTHWGEKKHGCPTCGKTFACKESLANHLRQHTGEKPFKCHFCPAEFTNRFTLRGHIFTHSGEKPYKCDHCGRRYALRLTLVRHNRMHTGEKPFSCDRCPAAFARKDTLDNHLLTHTKEKSWQCSQCSKTFARKATLTRHSQVHTGERPFKCDVCPAAFARRYTLHVHKGTHTGEKPYECGNVRPQIHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDS4</accession>
    <name>A0A9D4PDS4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDS4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16817" checksum="0BC909D661EC23A7" modified="2023-05-03" version="1">MDHVHAAGLACSATKSALLLMRPPDRRCLKTPHPTVMVHAYSTSVPVVSHLRVLELILQSNRRNTHTTDQLSLSVQQTARILAHLVSVSRALRAVFYIKPSRTCSRATMTHAIKPTCRFAWTRHVTLRPATPLPSSESRPPRRCPRSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF01</accession>
    <name>A0A9D4PF01_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF01"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048737"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="21389" checksum="1175D78BE82906D1" modified="2023-05-03" version="1">MEAARDWIGGIAGFATVGSLIVSLSMSWRVWRARDSSGVAFLPIAAENIRLLAFLLYGIASGDSYVTWVNVCGLAITFTNATVHCAFSDDSGPGLSLLAALVVMCIALSMMTVDWLGYLASAWAVACNLSPIARILRMIPLPEIAACTLTTCGLWTAYAVLAGKSALVVNYMVGTLVAAVELTMAMLMWCRHSAYLPVQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFE9</accession>
    <name>A0A9D4PFE9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFE9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="25591" checksum="CBFC6BAD450DF0B1" modified="2023-05-03" version="1">MADDEKERDVLTCDPGTAETSTSDSDDENEPGLPRWRRRRRRQRRLRKLQASTPSPATEPSTTETSTPKSFDPSNSNPRSASLSPVKRVAAAVVGAVCTALRKAIMSQCCIKPADEASSNEPSPVHHKPTPEELLQKTPEKPCLRRRTPDAISPILKVRFTGVPEVSTDEIDSSSTCEGEPDEQRLPQWPPRSSSQETREMPQSRKEHHVVVHVHPPPPTLPVEIAGSSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFN1</accession>
    <name>A0A9D4PFN1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043105"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="41142" checksum="005D69DEF07AC466" modified="2023-05-03" version="1">MSNRNDWSDVIAIKGAREVLTCVKYPKDSIRQSLYASWLRVIVSDSWQESFDHIMLECVAATPSPTDPSKPLFAYLFKRQDLMDLPFPEAPTPVLNNQKWTKLFVHKCKDNVEPLPSSPEFIDFLADLIRKSCSSRAALDEAGLIIGFYSLALAVVAAKPVREVQDFFRTRMKTVLAKAVPTSYDGDVFCTSGTFLNELSRRTYSPEGQVRPYLVLLVLGQYAYYLHTEETPPSAKVLNCILRDSGSREVALSSKCVQEYLEKADGPFQLTRPWCRATSISYFLHLNLFDHVDYAMRLTAFLAPDPNDLLWQRREFVDVSASRIKEARLWARNFKQALRKGDYGTTARVDQEQVGAAKETCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGF6</accession>
    <name>A0A9D4PGF6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGF6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039522751" description="Glycine-rich cell wall structural protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="34409" checksum="BAE8ED61F3123968" modified="2023-05-03" version="1">MKVFVVAALCAVVACGAPAKEAAKKEKVEGRGGLLGGGLGVGGYGAGVGPGLVGGGIGGAGFGGAGIGAAGLGGYGGAGLVGTGGLGYGSGIGLGRLGYGGLGYGGGLGYGRGFQSGYGSSAGGQQGGYQGGAAGHNQGSVGFGGGAANRNFFIATAVCALVACGAFAEEAAKKEKVEGRGGLLGGGLGVGGYGAGLGGAGIGAAGLGGVGLGGAGIGAAGLGGYGGGLGGYGGGYGPVVAGAGLIGTGGLGYGGLGYGGIGYGRLGGLGYGSGLGYGGGYQSGYGASAGGQQGGYQGGAAGHNQGSAGFAGGAATRNVNAYNNNQGYSHTSGFSASDSKVFGTGQKQGSAGFGSGGAGHQGGYGLQNFGHTAGTGFGGGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGV5</accession>
    <name>A0A9D4PGV5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGV5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039414108" description="Reverse transcriptase zinc-binding domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7942735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36447" checksum="94686EECEF03756F" modified="2023-05-03" version="1">MPVATRTKLVLEGLLFRFLWSGSSMYVARPVIKLPRNKGGLGIPDLGIVASALHLRWTRVALESDMLLTRSFASFFLSTRLRLFSPEAFSNSVPRAGTPSPFYAGAASTLARLRDANPGIELDSLELHDLVDLLTPDLPAHCVRYDLSRHSPNWKLITASFLDAKRATFMYRMARGCLPITFRPFTKIPTRGKCPFCGSREDLVHIFSQCALPAALLQRIASLYGHPGVPFETVRFLNPLPAQAVNQYVLLLVECSYQVWVARCAAVFDGRRPGLHELLAKVRKEIWFVLHRERQRLGVKKFLETWHRPAVIFSESGGQITITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHG9</accession>
    <name>A0A9D4PHG9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroendocrine protein 7B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_016263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 7B2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHG9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031683"/>
    <dbReference type="OMA" id="RAKHEEP"/>
    <dbReference type="OrthoDB" id="9922675at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007945">
        <property type="entry name" value="Secretogranin_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738:SF0">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05281">
        <property type="entry name" value="Secretogranin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038934714" description="Neuroendocrine protein 7B2" evidence="10">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7939710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="310" mass="34301" checksum="090CD3B846395740" modified="2023-05-03" version="1">MINGRLFFAAVLLNAATRSFTFNPASYDRGLEGLTDGFLKQVMSRIQGSGLDLSDSSLEFASDQRAKHEEPPLSADVYQRDPSFGAHHLGRYRKENGGQAPQVDILGGPSIRDQEYLQHSSLWGHQYVTGGAGEGFQRLKPDGIAKNVQVVKTDAVLPAYCNPPNPCPKGYTAEDGCLEKFENTAAFSRDYQAAQDCMCDTEHMFDCPGATQENEIDALARSIQNEGLMESTLDRIVQHIDPNVPVEGQHKTVMAKKFFKKENHANYAKRFSRKSKKSVKQPKTTPAKNPYLQGEKLPVVAKKAPLAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI79</accession>
    <name>A0A9D4PI79_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI79"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7942707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="116" mass="13492" checksum="C11315F0C2570520" modified="2023-05-03" version="1">MYYTWQTRRRRPHCRTENRVSTPRGYLEIPSTTEGHRSQHPLAPQDLTEDSICANVTQHIFILYTPSERNARGSTTVHQLHLRDTLYGFAVYPAPPDDTYKGVIRSIDLDHNQLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJR9</accession>
    <name>A0A9D4PJR9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_018212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040768"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041701"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7944310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46134" checksum="48FEDBEBBC70260A" modified="2023-05-03" version="1">MGLWFTVAFIAFALTLLIRFYNGDVPFLLVKDLDFLEYAYIKNFQNFTARGVTMRTDQMHPVVGQMVIHVRGDQWRRMRSCVTSGFTSSKLKQMVPHIAESAEVFMDMLELYADSEKEVNLRFQFQALSMDYIGQAAFGIETCFQREVDNIFFTTARRVLPGVMTGPAHMIAQSTTTMGSAMKPFYWFLGQFGSLTFKVFSRETTKMIEKRKSHPELRKPDILQNLLDAEIEEEALNEVVNKSEAQQTADGVKKRVRALSPREVIMNATLLFMGGATSRQADEDFEWNGMKFKAGTCIMSPTYQLHRDPRYWTDPDTFDPERFSPENESSIYKMAFQPFGVGPRHCVGFQMARLELRYTLARLVQRYRVELGESQKGEMNMGGYAMISAPENGPWLKFYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLM1</accession>
    <name>A0A9D4PLM1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLM1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030489"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="14102" checksum="0D69F68E4D422F18" modified="2023-05-03" version="1">MVNSDQLRKKRAALRAGLTIALTHLKDLLQQPNPDAFQINVHMDCLKDKEAALTRLDDVVLATTDEGNIDEEVETAHEYNETILYAVSHAKFWLQERETTARTQARAMGPGQATMNLETPATQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLZ5</accession>
    <name>A0A9D4PLZ5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLZ5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24494" checksum="815C3F9573A70DDA" modified="2023-05-03" version="1">MEAVEVEDISEEEAFDPGWKVAYGRRCGKTREPYCSAQDGGSTRGRRRDGGRTAEPRDEIRRVTLASRLPPVPRDTFRIVVRPRDGLNANKISRIRFEEALAIAVALAPAEIEEDTMCPNCVQNIFVVCTPHEKNVDAYARVQLIGLGEGTFGVAAYLAPPENTCKGIIRGVHVEVSEAQLTARILKHRNPGALEARRIKNTTAVRSLRPSVSYFTSFCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP16</accession>
    <name>A0A9D4PP16_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP16"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050665"/>
    <dbReference type="OMA" id="QYHTISH"/>
    <dbReference type="OrthoDB" id="10007483at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01217">
        <property type="entry name" value="PTB_CG12581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219:SF3">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="548" mass="60455" checksum="24A5D2FDE4FE3B5B" modified="2023-05-03" version="1">MAHNASTTPICRCRVLYLGSAVPHITKDGLQGIQEPLRELYPDQGPVSARGIDSWLSVWSNGLLLENVDESLRQHVRFFPIETLHYCAAVRHVVVPGSSGSERVEKFLPLDSPFARHAGPQQPPLFACILRRTTGIKVLECHAFICKKEAAANALVRCCFHAYADCTYAKQLEENPYVLDGPPRRAQSVVGLDTVQKVEAWRHQQAEPSTSNGVPHANGGSILLDDDTEDDEGNYKIWTGPAPRELVYMDTSGTLRSVQSTATGPPKSSRPRQLAIPSRPPPPPLPPLPPPGTSKMNGHKESSKPKKKSKSKSSSNSPQQQQLPPMPPPPHINGYSVISGYSGNHPPPPMMIHSERMRRPPERPMLYSAEEPSYIPAVRAMSPTASYQPGMYPHEQYFMQNYSTAPRPHGSKHRGNGEHPPSSKPSKEHRRSNGHHDDSAGGDTDSPFNTGIYRRKGHLNERAFSYSIRQEHRSRSNSLANLHFLNGGPEGNGDPGPSGMDKKDRELAQLVGDLDLRDNNGYGGPSHRPVTPDTNFTRKKASSKNYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP91</accession>
    <name>A0A9D4PP91_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_019945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP91"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056655"/>
    <dbReference type="OMA" id="WSCECSY"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000418">
        <property type="entry name" value="protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001348">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039433553" description="TIR domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="966"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="1016"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1157"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7948259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131572" checksum="A694B1A4C2DF63EC" modified="2023-05-03" version="1">MVWSVLLLGVLVGQAWAAHYVSADDCDWRTGPASPEVALRCRLQALRTGPDSTNFSLIQPDHTTSLTVLCSALFTESHLGNATFSSLRSLRALHLEQCKISEVPERAFAGLTELRNLTVRTYNGDWGALSLALAPRALEGLSLLQRLDLGHNNMVALPPTGLCSLRQLRSLNLTHNALETVAGLGCLGALSELDMSHNRLRQLDDGVLAALGSLRSLRLRHNRLDRLAPAALAGLAQLQLLDLSHNQLSGGLPPGLLGGTDLRELYLQNNTLSLLSPRTFSGLEQLVILNLSRNHLSSDGITHDTFADLIRLVILDLSRNQLRQVNGSTFQSQYSLQILHLEHNLIENVDDNAFSSLYNLHTLMLSDNRLSHLSVFTLNGLYVLINLALDHNRLENIHLDGFRNCSSLQDLQLSSNSLSNIPDALQYLHYLISLDLSDNRIASVSNATLSGMPNLHILRLAGNRIGNMTKGTFQSLHSLRRLDLSNNQIASLEHGIFDDASALNVILLNDNLLEDINGLFMNLAHLRLLNVSCNSIAWFDYALVPRQLKHLDIHQNYIEALGNYYELEDKMHLKILDASSNHIREINAGSFPNQIEMINLSNNRISIIHPFTFMIKHNLTKVNLTQNRLQNLDINAFRLKPTKSALPEFWIAENIYFCDCSMEWLQRINSLDGQYPQVMDLAKVVCQMPFGRRRPRLLLTEANSSDFLCKYKSHCFALCHCCEFDACDCEMVCPENCTCYSDQTWNSNIVDCSFTAHSTIPARIPMDVTELYLDGNDMTHLSSHSFIGRKNLKALYLNNSNIQSLHNRTFNGLVGLQVLHLDHNKITVLLGHEFENLTSLRELHLSHNRLSSLSNRTFAALRSLEVLRLDNNYLLEFPVWQLRANAVLRHVQLGHNPWSCGCAFLSRFQAWARGSPLRDAASVRCGRRGPFLLEFDASSCGGANGTGWAEAPAAGAQEPHQLPPGLVPLLIAAPSALVLVLLGAVLAACYRRQLKLWLHSRCGLRLFDRASESPERLFDAFVAYCPKDEPFVSQVLAAELETCSGGGKRRPLRLCLRHRDLAVPGCVAEAAVVEAVQCSHRTVVVVSEQFLRSEWCRFELKAAQASSVRRLIAVLLDDAGQDQWDVEARQCLRSALILRWGERRFWQKLRYALPDPQKGPPQRGGPPEPVARASAVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQD5</accession>
    <name>A0A9D4PQD5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQD5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="8452" checksum="93B34533C4A98076" modified="2023-05-03" version="1">MADKPDAAFAGVPGLQQPPNFDFNDPSAWSTWIEQFEEEERPYFITISETMRAHPLEWLMAATAYSVVRVVIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR10</accession>
    <name>A0A9D4PR10_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SWI/SNF complex subunit SMARCC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_008859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR10"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058022"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="195"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7951417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60412" checksum="02E2AB1525C86D6C" modified="2023-05-03" version="1">MEPDSPQTHTGPYEVNAKWLVDLDEYNEWMNEEDYEVETDAMGRRRSPRGKYTLDELLSGEGEKRDRKGIKKRKRSPSPPLDKRKRKGGRSPAMGKKRSFRDDESDDLTKDMEEPSPEPSLQEVSIPRSNPNQRSSKDSELQPVKGGTLIDLDGADMDDKGDRDKGSRPGSPNGVGKSEKAEAHDDNVTEQANHIIIPSYAAWFDYNSIHAIERRALPEFFNAKNKSKTPEVYIAYRNFMIDTYRLNPTEYLTVTACRRNLAGDVCAIMRVHAFLEQWGLVNYQVDAESRPSPMGPPSTSHFHVLADTPSGLQPLNPPRTQQPSAAQQMLNLDKAKEEGGGGKDEGGGIPARGGAANATTIGGDALGLKMDQYAKKQAYLRHKAAATVSREWTEQETLLLLEALEMYREDWNKVCEHVGSRTQDECILHFLRLPIEDPYLDDPAAGGGALGPLAFQPIPFSKAGNPIMSTVAFLASVVDPRVASSAAKAAMEEFAKIKDEVPSALLDAHIKNVETAAAEGNVNPKAGLGMTGIAGTGDKEPQEGTAEPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PR57</accession>
    <name>A0A9D4PR57_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_002416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PR57"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044007"/>
    <dbReference type="OMA" id="RNCTIRA"/>
    <dbReference type="OrthoDB" id="10065302at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039710126" description="Receptor ligand binding region domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="76"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7950854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="263" mass="29275" checksum="2874547B7248D44F" modified="2023-05-03" version="1">MRRRGPPAIGAVVALLLCYGALSAGGVLLTGVVDDDGDGYDSTSPQLPDETSWNNTVRMSVLLPGNSSYLFSLARVRPAVELAVSRSSREFGWQFRVTYRDSGCQSPLATMHAVRDHARGAAHVFVGPACDYAAASVARLLKFWRLPMVTAGALAYDFWDKMHEGSEYYLMTRAGLSFSGLCQGFLGLCRRFGWRRMLILFESEARKESHGDDYCFLWAKAMAQLLRNSSDNFEFDGVKLDKRTPLKQQLIKAASTKWSSEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSB3</accession>
    <name>A0A9D4PSB3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_018376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSB3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025929"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7952098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="541" mass="59164" checksum="49BB8C02411622C4" modified="2023-05-03" version="1">MNSLGTLTFDEYGRPFIILKDQDKKKRLTGVDALKSHILAAKAVANIIKTSLGPKGLDKMMVSSDGDVTVTNDGATILKMMDVEHQIAKLLVQLSQSQDDEIGDGTTGVVVLAGALLEQAEQLLDRGIHPIRIADGFEMAARCALTHLDKVAESFSVTKEDKEFLIQTAMTTLGSKIVNKCHRQFAEIAVEAVLSVAQLDRGDVNFELIKVEGKEGGKLEDSLLVRGVLVDKDFSHPQMPKEVRNAKLAILTCPFEPPKPKTKHKLDVTSAEEFEALRTYEREQFEQMVDQVKAAGANLVICQWGFDDEANHLLLQKQLPAVRWVGGPEIELIAIATGGRIVPRFSELTADKLGSAGVVRELSFGTTKDRMLVIEECPNSRAVTVFIRGGNKMIVEEAKRSLHDALCVIRNLVKDNRIVYGGGAAEISCSLAVGAEADKISTLEQYPFRAFADALESVPLALAENSGLPPIETLTEVKARQAQENNPCLGIDCLGKGTNDMKEQHVIETLTSKKQQISLATQLVKMILKIDDIRTPDNNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSP3</accession>
    <name>A0A9D4PSP3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSP3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038023"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11728" checksum="0C713FCAC69086BA" modified="2023-05-03" version="1">MGATSNNSGVLSTVLIFHGIDLNLPPKSAVHNLADLLAHLGLSKYAPMLEAQGIDLDQFLTFGDAELEQAGIRLIGPKRKMAIAISCWNERERQQVEHKGTAQEHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PST1</accession>
    <name>A0A9D4PST1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PST1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14774" checksum="03327E51D39CAE1E" modified="2023-05-03" version="1">MHSDMEADDRPFTTVTYKKARPAGIPVIFKLTDPGASFWKVNPNKLASEVVTAAKEKVQSFRVNRDGNFSGSQVIQWKSTYNPLLDVTTVSHMAMSPNRAMDNSVARSVPERMITKTALRGIIQNVQTAMETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU29</accession>
    <name>A0A9D4PU29_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU29"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="323" mass="35511" checksum="FDC2BB115CA0465D" modified="2023-05-03" version="1">MAYAVEGNDLDPSEFNDGSWTLALDMQKKYRRRTGTVSSPINGETTLTSQSVPTPRRQARPPPTVRRRPMPRLSEDDYKVVLRPNGAINLTDVGPGIIVEAICIAASIDFRGTQRRPVSTPDRLRAEAYRKITQLQHERNALSIPVAAYVPAPDNSVKGVIYKAHSYEDDQAIYEEVSGRNPDLPVGEKPTCPSSCVVCGGGHQTGSRNCKYRFITKKQPGKPVAADNAKGQEIDKPAPDSIPSQQGTTTKNKTAATWESRSKENNGGESWSRSESFPPLRGRSESRDRSENNDNHDAQPGSLTRCRGANKITQRELSAHETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PU61</accession>
    <name>A0A9D4PU61_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PU61"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056649"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="12706" checksum="6924222651EB0445" modified="2023-05-03" version="1">MGIVVLQIAAEWAPLFESAPLSRRPNIRERSQTTADVADKTRSDNDDDVVVTLADVERLGTARMSTSARGYYQSGADQQQTLGENTSAYRRSVASKGPSSRPFHSRYSTRSLNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUS7</accession>
    <name>A0A9D4PUS7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_005520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUS7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047560"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7956007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="190" mass="20962" checksum="F2DD8D85B0A35A77" modified="2023-05-03" version="1">MECADAEFLAEKTQVTIIPTFSAEKLYLITGDVGPFAAGSPLSVPLWMALNLKQRQQCRIVPPAWLGKQFLEDVKQEEAGSPVFTRMPCEHYLEVTQMLFDVAAADIPDASQVRTLVKDIWDLRQAKLRSSVDAFVKSDEVHARVDHLTLMEAIGVRRLLCAALGHLHKLRQVAALLVVAAAGRGFPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWR6</accession>
    <name>A0A9D4PWR6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 35 member F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_015724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041718"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43206" checksum="8035FE3EAB65A149" modified="2023-05-03" version="1">MAWTKYQVFLALMLVFTGSINTLATKWADSSLSVGRDGKLRLFDHPFLQAVGMFLGEMSCLLAFRVVFFYYTRKAKAGEAVELPPSVSGSRDFNPLIFLPPAMCDLVGTSIMYIGLNLTYASSFQMLRGAVIIFTGLLSVAFLGRRLRSYEWIGILAVMCGLVVVGLSDILFPDSHATKGPNSIITGDLLIVLAQVITASQMVIEEKFVTKYKVAPLQAVGWEGKCFFGFVVLGLLLVPMYFIPAGNTIFQNPGGQLEDAIDGFIQIKNSWHVTLGVVGTVLSIAFFNFAGISVTKELSATTRMVLDSVRTLVIWLFSLAVRWQSFNWTQIVGFMVLILGMFLYNNVIIRPFLIRQGCIRDTDAQDDLSGLIQEERPPGSSRPPSSTDEANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXC6</accession>
    <name>A0A9D4PXC6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043152"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51300">
        <property type="entry name" value="NIRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="415" mass="44977" checksum="6A03514CA3013FD6" modified="2023-05-03" version="1">MLPSLCPPAKPFHPAYPGAWFMQLDAILALNGITAQPMMHAVLLQALPVELHHLSAASFSSPQPYDDFCAAVLARYGETYRPLPGTREFRISPPSTRAVPPGPQPSHDHDLPSLATTSPTSHEATSASIPAPDHPPDEVQEVPAAIGHSTETSVFSTASAHGSTTATSPHAMESAIDRDIVTPAIRPPIAEASPAMMSDEPVFPSASTLCASCQQRPASPSQFLAAEVPALNHRWPNLRDAATMTDAPEDDVPEFQHEVLVKLTVLRMVKKQHGELLHGLITRLPLRSNAAKGNAPLVSSPFSEYESLKQFDNKLTGQMKDVLVYDKDFQMYVDIDDEFVILDKAKFLIKETVQYGRSTLPHESASANVAARNNWLQRWDGASLWVAVCDRIRVAAGSSAAALVLFQASTSLFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXH4</accession>
    <name>A0A9D4PXH4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXH4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16783" checksum="3038F3773183F063" modified="2023-05-03" version="1">MEQFQGKARKRREPPPNPDVIFTSTNQKQQEQQIQRSDTTSKKSFASVVKGNQKDHHLQRAKKSPLVIQMQVNNKCPQSRNRTGRAKKSCWVAAPYRTIKYADSMMFAAIKALLCANPSLKDIPEVQAVLAFEPLVTTSPTAQRRGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXW9</accession>
    <name>A0A9D4PXW9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_022657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047991"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000008">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="12">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SLX1-type" evidence="11">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7957775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="255" mass="28985" checksum="DCBFF21B7BF516CC" modified="2023-05-03" version="1">MQVEQFYGCYLLYCTNPKYKGHTYIGFTVDPNRRIKQHNKGFKAGGAWRTSRKGPWDMALIVHGFPNEISALRFEWAWQHPDRSRRLSHVGKKLRTESRFAYAFRVVSHMLRAVPWVRLPLTIQWLMEDYQLDFKPDLRPPLHMAIAYGPVKAVRAPATRDSLDSALATLACAVCGGPLERKRSLAECPYPECIAVSHLCCLARLFLKSEPNQTIPVGGNCPDCCNWLLWGDVVRHNRCNYVNSTAAHVAQSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q078</accession>
    <name>A0A9D4Q078_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q078"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041698"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF7">
        <property type="entry name" value="RE45222P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48219" checksum="442570737D0E36E5" modified="2023-05-03" version="1">MSQRPQGEPYPFEIIKKKTLEFLSGTLPLLRKDPNLPKVARFAGRPPPGFPGNLFAVPPGHVRRGRRSLAAFNSTRKTENAYQSLQEAEREWRGQRSYESTTMHDLARAFNATFRQLCQHGSGTSPLTQVLSALTGATGTVASATSPLVTVLDLMTSDSSPIKLLANVYSSTRKKSKPSDSAQQSSLENDVEGLPPTPCPSLEEYVTPTFARNYQGVWKYVVQIPHEGYLTQTVQQTKCMSSRCDFVDGGLCHESPRWVSLLVAEIFYPHAVFPTTSPQRRRAPHPGAPLQAQSPYYPHPQQMLQQPPPPPPVGDFHAFQQYLHRRVGADQQQQQQQQQQTLSVEKQRSQQEQRPPQQAQVKRRNDVSPAGPRAAARSRTSASSSKDKCDGYDHVGCYIVRMYYDWFLVNGSCKCWKPSSKHVFTAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q093</accession>
    <name>A0A9D4Q093_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q093"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051010"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="13076" checksum="8B7D3E42A28A5CDD" modified="2023-05-03" version="1">MHSLAVCFSGSCPTHTPCVEYSEEFRDIVGKSSKKAAIPESGITLVNQHKIARSYLVKKAYNPFEEDDDRMRSTTRATWDQFEKLEDEDEQGWCKGRKDGRVGLYPANYVEVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0E2</accession>
    <name>A0A9D4Q0E2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_014912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0E2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000025">
        <property type="entry name" value="Putative Beta-arrestin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="197"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="411" mass="44891" checksum="7665A3CD55C560BA" modified="2023-05-03" version="1">MSMDDSPSCASVTLVAAVEEAKRQGGTRVFKKSSPNGKITMYLGKRDFVDHITSVDPIDGVVLIDPDYIKERKVFGHVLAAFRYGREDLDVLGLTFRKDLYLASEQIYPPPSGECRTTIDAAAGAATAQAGPQCPAPGDTGKPCGVDYELKGYVADSPEDKPHKRNSVRLAIRKIMYAPSRQGEQPSLEVSKEFVMSPNKLHLEASLDKELYHHGEDIAVNVHIANNSNRTVKKVKVSVRQFADICLFSTAQYKCTVAEIDSEEGCPVGPGFTLSKVYYLRPLLANNKDKRGLALDGQLKHEDTNLASSTIITDPAQKENLGIIVQYKVKVKLCLGPLGGDLVAELPFILMHPKPEETTPVRAVSEPKAPGPVPLDTNLIELDTDAAASLDDDDIIFEDFARLRLRGETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2J2</accession>
    <name>A0A9D4Q2J2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2J2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="81" mass="8619" checksum="57A332ADD88B1D26" modified="2023-05-03" version="1">MGVVAAGIAARRRGVVTLSGTVGAYRSLARNAVETSRAIDMPVTCAAAFKALASATRNQKTCRQERCFLVPTARLPLRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q373</accession>
    <name>A0A9D4Q373_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q373"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="23543" checksum="1CBE6B719E8291C9" modified="2023-05-03" version="1">MRGGSASSGKPSVSPSRGVARENHARAELFEHSYSATSLGQKGQAPGGGRGAHATAAAAMNAPRTKRLRCIDGDPGPGDKRPRPSCDSDSPSENGSDDESTTLGDGVDTSRPSTPPPTPQRRQVVGSPQAPPSVPPSGVKRRLFDSEESSKRMSPAFKKYKTSMLLRYIGADQLRETPVRETASTVQAPSKQSRPTAKRPREEQHVHTTEPRKAVPEGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7L8</accession>
    <name>A0A9D4Q7L8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7L8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044126"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7969363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24285" checksum="3DB0B2F8F8DFBDF8" modified="2023-05-03" version="1">MVRALAGNRLLMRPYTPVSPCDRRGTFDIIVKVYKAGVSPRFPQGGLMSQFLDSLQPGDEVQIRGPRGKFVYEGHGAFVTAHGDRLPPVKRLGLIAAGSGVTPMLQLLRNMFADSTDCTLVRMIDVNHSTREIIACSELNDYARSHSSTFRICHVLSEMPSLQLMPGVIQGPLNRYIMAAHLPAPNSKSLILCCGPPSLIDKVCRPALADIGYKSEQVLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7Z9</accession>
    <name>A0A9D4Q7Z9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7Z9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048367"/>
    <dbReference type="OMA" id="TEQILMY"/>
    <dbReference type="OrthoDB" id="6477726at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7969610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="33113" checksum="13FC42EF21D74D3D" modified="2023-05-03" version="1">MGSSSTSSFMSALADELILDRDPRTADWVLAGNREFLVSLFMVYVYVVKVGGPRFMKDRKPYDNIKPIVNIYNACMVVLNAYFMTAFLSKTYMGGGYSLFCQGINYETRDEVTMSLLNLCWWYMLVRIADFMDTVFFVLRKKDSHVSFLHVAHHILVVFNGCYGVGYGPDGQAALTIILNCFVHIIMYTYYFLSLLGPAVQKHLWWKRYLTQVQLVQFCIIFVHMLVPMFYNCGYPRPHIYIMLCEAVFFFTMFMRFYFKAYRDRNSTRRITDESDRGKSKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9H0</accession>
    <name>A0A9D4Q9H0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_002377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9H0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049367"/>
    <dbReference type="OMA" id="GFECDDV"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7971720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15154" checksum="CD1E0C01B829479B" modified="2023-05-03" version="1">MAENSQQTSLTATVKHESGASSPASGVGTTESRSGPSGQSLSELLLQLEDYSPTLPDAVTAHYLNTAGLEASDPRVVRLVSLAAQKFLSDITNDALQHCKMRGAGQSKKATKDKRYTLTMEDLTPALQEYGINVKKPHYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9I1</accession>
    <name>A0A9D4Q9I1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 12">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_011510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9I1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029509"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053367"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="15">
        <location>
            <begin position="573"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="545"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7972370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="840" mass="92336" checksum="C739F6EC05B9F7A8" modified="2023-05-03" version="1">MMMNVPEGTPVDSSVSALEQARCIPPSKLRQEYLDLLELVGHGCFQLRILFCAHLSLVMVLFHQWSTHALTQPVDHWCKPPALFAHLTRDQWLNVSVPVVEDSHGNRRHSQCAMYDLSTIVFNGSRLEVPCDGWDYDLPPDTSTLVSKWDLVCDRAPYVLMTHVYYTVGGVLGAPLVGQLADRVGRRPVVFGALLLSMVSVFTATAADSFPAFVVAHVLIALCTSTVYFLTSILLFESSSSAYRTLYIAAAETGAPLMQAASMSPWLQRMDLRFTRIALVVSMIVLSLAFHAVAESPRWLLAVGQYDALTAVLTRIAQENDVEIGDVWRLVHYAEVVKPLQAGMPFQLSDVLLLPELRARTVALSVLWFWCFFAQYSIALVRPNAATSPSQIVPMLLLLVPVYAAGYPLVTRWPRRTSLHMALMVASTVAVAAGAAHYSENALVAEHIVDLLLAAVQLCLLVAKLLAYECFPSAVRATAVHVVVAAGCLGQGMAQFLVDVARVADATSALLIMAVGLLTCEMAVRWLPETKDVELPEVQGDVLAQGSHPQQASSPSKEEMLPAKRTSSTQPCSSRQASKTTARNTKRIGNKQSPVNIVTKDVTPDPYLRDNPLQWEDTGLRGTSISNNGNTWQVSVKAAGPNLRGGPLQHDYQMEMLHAHWGKTNDSGSEHAVDGKRYAGELHLVHFNADKCKSFLEAASSEEGLVVVAVFLIEGAAHPLLKSVVDCIPYIKHKGMKCVLQQTLDVSLLIPAGSTYWTYEGSLTTPPWYENVTWIVYKQPIEVSPAQLAAFRTLMSYEERVDPQKSSDGPIECNVRATQPLKRRIVREPLKKQEEATHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA84</accession>
    <name>A0A9D4QA84_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_008584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043567"/>
    <dbReference type="OMA" id="QMRTNET"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000022">
        <property type="entry name" value="RNA-binding protein Nova-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7972170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="545" mass="56126" checksum="F846D647041AD729" modified="2023-05-03" version="1">MATGLGGVNGCPDPDIGDSRKRPLDSELDIGATKRSHHGGGNGTFHFKILVPAVAAGAIIGKGGETIALLQKEAGARVKMSKSNDFYPGTTERVCLITGSVEGVLRIHEFIMEKIKEKPDPTAKIAIDFDHKQPAEREKQVKILVPNSTAGMIIGKGGSYIKQIKEESGAYVQISQKSKDHALAERCITVIGEMDNNKKACQLILAKIVEDPQSGSCLHVSYAEVTGPVANFNPTGSPYANPSSVHSTVNNSSASYSSSGSLNSLSPTANFGGAAGSMVPAPFPGANVAQLLENVKAVLRSNGYTEQATADIATAMGTLATYGVLGSSLGALLAGANGAMIGQGPPQPPPPQQVYPTSPMDATPPVVASSSGIFGPVGSGGFGSPRSDRYHSDMVFDPFRRNSPALGSPGAAANNGAGGGMPVNNNSFGLGTALVPSQGAMCKSPPPPSAADKCSDAVKRDLEVGENIVGAILGPGGKSLVEIQRFSGAAIQISKKGTFAPGTRNRIVSITGTPNAVSTAQYLIEQQIAEEEAKRSQQNALGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBE9</accession>
    <name>A0A9D4QBE9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_007921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBE9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048499"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="24263" checksum="0689C2BF4D4DA200" modified="2023-05-03" version="1">MVADDPVEEVEVAAVRCQPERIEDLCRATKFSRQELKFMYQGFKQVCPTGVVHENTFKEIYAQFFPHGDVSQYAHYLFQAFDQDHNGTITFQDFVVGLSALSRGAPVDKLRWAFQLYDLNGDGIISRDEMTDIIVSIHSLVGAPHHAHPTSSAGGGASSTGAGSGGPDDDDPDSVRDHANRVFQKLDLNQDGVVTIDEFIETCLKDENVMKSLAILDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBI7</accession>
    <name>A0A9D4QBI7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_014787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBI7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044709"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038911100" description="Cystatin domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="16935" checksum="8615C4F02E6B0F42" modified="2023-05-03" version="1">MAAIKPTCMIMLLGVWLGVLLDSGYADSSLTGAWQEQNPHGDPQYLILAHYAVSKQTKGKKMYDTVVRLIRVSTQVVNGFNYKIKFVAAQSNCKIGRDQYDAWKCPPVKPANKECEAVINVAPTTNARKVVRYSCLLIVFPGDNFNALSAAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBN3</accession>
    <name>A0A9D4QBN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HPB52_010778</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
            <tissue evidence="21">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 20">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056166"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:O-phosphoseryl-tRNA(Sec) selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001717">
        <property type="term" value="P:conversion of seryl-tRNAsec to selenocys-tRNAsec"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03531">
        <property type="entry name" value="selenium_SpcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18 20" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 20" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA variable arm</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA discriminator base</name>
        </ligandPart>
    </feature>
    <feature type="site" description="May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate" evidence="20">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="20">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH7972279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="483" mass="52732" checksum="7464AB66FCF35FC2" modified="2023-05-03" version="1">MNPSNIALAKKYVKPTYVAQAGQAIGVHESKVSQLLEQGRIPDEGWDDSTIELLLHQLSMMDSNNFLGNSGVGEREARIASTLVSRRHYRMGHGIGRSGDICETQPKAAGSSLMNKLTNSMLLHMLQAAGVPSAKSCFIVPMATGMCLSLCMLTFRKQRGPRARYVVWSRIDHKSCFKSILTAGFEPVVVELLRVGDELQTDVAAMRSRISELGPETVACVLTTTSCFAPRAPDSLEEVARLCAEFDVPHLVNNAYGVQCTKCMHLIQQASRVGRLDAFVQSTDKNFLVPVGGGVVAGFDKALVDSIAQTYPGRASAAPTMDVFITLLSLGLSGFMRLRDERRIMFKYLQESLSKVAEKHGQEVLKTPNNRISMAMTVPSADADAVTGIGAMLFTRLVSGARAVPTHRTEPKKGFALTLYMIFHRKAPKKEEGVDYMKLIATAEKGADSGTLFTLYQGKVARQNITKEGLANIREGPEETLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBQ4</accession>
    <name>A0A9D4QBQ4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_019113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBQ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044669"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10574">
        <property type="entry name" value="EVH1_SPRED-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000052">
        <property type="entry name" value="Sprouty-related, EVH1 domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041937">
        <property type="entry name" value="SPRE_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF3">
        <property type="entry name" value="SPROUTY-RELATED PROTEIN WITH EVH-1 DOMAIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="5">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="400" mass="42556" checksum="D69AD71E1564BD10" modified="2023-05-03" version="1">MANCARVVSSSGGCLVRVRAQVMTRDDSTGGWVPLGGGGLSSVSVRKRCDLQPNSTTAVPGACCYQITGEREARVLLSCAIGRDFTYNKVMPTFHHWRAGEHKFGLTFQTSADARAFDKAVRIAMEDLLDGVGDMCGTFPDSDIGDDDVFMTLELPVDSRSSSGSSSAGSGLSPYSANHHLHRINYVRRNDGGPPPSNNHHKGGLLLDDAGNPVQQQPPEPYSYVQFAKHDYSYPLVETLKSGVARDAGAAVPPGGAPVTGQAATVPAPGKKGAAAPPLPSKARGGQKRRQCRHCLEEFSEDSNVRGSCEYAPDNVLACINAASCISCAHCMLYHCMADAEGDFSQRPCSCSGSPRDCRRRWAGLALLSLLVPCLWCYLPLRACHRAAVGCGLCGGRHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD73</accession>
    <name>A0A9D4QD73_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ixodegrin B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD73"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046639"/>
    <dbReference type="OMA" id="ICLNTEE"/>
    <dbReference type="OrthoDB" id="6510634at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038942118" description="Ixodegrin B" evidence="2">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7975816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34299" checksum="01F43242D232C9FC" modified="2023-05-03" version="1">MLLRLSFFLATCALSMTAEVAINDRNEDDPFPKWLIDMGSTVNESDTAIYSTRRPRVTGKVKGGTICLNTEECGVGKCCLRRGKDPRRKCRRYQRIGQRCTDDQMMGGYYQNYCPCNRHSICTVVGHVLKCVKKQPIQRPGPRGPRPATPPQEEKESKESEEISNRPGAPPKNPTFNQTKLEFPEIPEFFKTFGTSESSLFPNEGGGEGEGEEGGEEGEEEGEEAGKHGDDLPEDITPQGQPLPEEPPEESTENEGAPTVTKPSPAQGSHSPALSGGRRLSGPVNHGPRASPQEGLPGANNVPHLPPSPLQPAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDC8</accession>
    <name>A0A9D4QDC8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_003253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDC8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036042"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7975573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="420" mass="44582" checksum="BA6EA4667305BE34" modified="2023-05-03" version="1">MDAEAEARLTLTGLVRLVREEQWQQAQELLDLVRARGKNLAPLSPSANVVRRVLRLIRDEYASAVLGRQVEADRDSLQKLLLARDDSVSDYTRPFPGLREQLLDSLDELERELRHSAENVAAQGPEHIQSGDLLLTQGRSRTVEAFLKRAAQNQRTFQVLVAEGGPRCEGVQLAESLARVGIATTLVPDSAILALMPRVSKVILGTDCVLADGGLQAPCGSHALALAARHCAVPLLVCAPGATLSPLLPWSESAYQQLGSPEPLGPEPRSGALLLNPASDCVPPDLVPLLVTSAGGHAPSAANVRSLSCARSCDDERIDDAFRELSSLFPAAVPPEVSADNFVEADCNVQAVASLADEDIVAAVAGTQDAQADSSSDEEDRPDEAVATRAYSAAEVAAAFGLSRRCRGDMEGTGLSHLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QED0</accession>
    <name>A0A9D4QED0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QED0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032650"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7976245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="348" mass="38533" checksum="1D3DA7103E5A0C25" modified="2023-05-03" version="1">MIVSSCQTQTPSSTPASPCGDRVTRLRSNRSERKHVSSNKSLVLKLGVCFLYLVALQNAVSTTFKCAFTRIPMNVLDAVSVACRTLFAALTSHLYCRSYPDIVRFLSRDRKLDPGLYQELKDSIVMRRKRWLAHGLAVAYGVAMAVHQCAWLYRYGPLVYFRSQLYNLDPVALRMRPSVVAFAAIVDFTAFNVAVLVPAFCMAHYVTVCDLIVLKGSRFRGLLKGYCISGGDGIKVSTVRKLQASYASLKDAVQFVDKNLRAAVFIWYVDTVLNIVVSVRSVQHTLAHFNAYSAAGAYVHAAYLAAAFLLVSLSAANLVAQRRHLLHDMCRLVCAIGTAEDDELCNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEY5</accession>
    <name>A0A9D4QEY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_000453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031641"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039155102" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="87"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7981654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="241" mass="26549" checksum="3B29F5B520946FC2" modified="2023-05-03" version="1">MELRATLLLVFTLIVGSSGQFGIQLEWHNPNVTDILGRAPGDPVSIILTNYNNMQYYGVLTIGTPPQSFKLLMDTGSSNFWVPSVNCDQSMACRDHAKYDSSKSSTYTKNGRYIRIRYSGGVVRGVTSIDNVGVGTATVTQYKFAEMDHSDGKLFRNAKYDGIFGLAYPSISQNAQLPLFDAMVKQGVVREAVFSLYLSKQPSEQNGGEIYFGGINAQRYTGAVHYVAVSQAGHWQVVMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGB1</accession>
    <name>A0A9D4QGB1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGB1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="380" mass="40053" checksum="BD3AFE8B92F43394" modified="2023-05-03" version="1">MRSGERHEEEGSNGHADNAEPNQAAAATEAERAADSGEGEKRGVHGTRSASADDKGEDDAASAVSWASVDETAAEESCHEDGEGVGKEDRPEARKGSQGERKPSLKGRTGLAASTAAHSPWWNKTGDDDVPRGREAPQPANDQSVSGSVEQEKSRKAPGEGDAPKPTEPSISSRKQPRPEPAPPHGGAAQQHSREGAQHGVQHGEAGVKTSRGGKTAAAVLEAQKPAGTPSSDELEPGELVIDERAPTSPESPKHTQQQPLSMPAGVGRGRHSRSRDSEAAHGGTLFQSLRPSGTGAHKADGGRPQRSVKKVRRTPRGACKAARRAVSTRRRRQNSVQASGRRPTTWTQTATSSDRWLRSMFSPTALCLQGCPRQRGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QGB9</accession>
    <name>A0A9D4QGB9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QGB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032239"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="15140" checksum="957F0A4EA17A7EF7" modified="2023-05-03" version="1">MDTQRAMADLPELQRRLLERSRLLGFEPYADAPMRVRDRPSSEQDSGSGDDGEEACAVEAPVSRPRGKTCASGSPDHDLTPPELFRWCVEQEVLRRYGVTLEASVFCVQTETPKDIEVGLVVFWQKVVGTHETTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH22</accession>
    <name>A0A9D4QH22_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH22"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="122" mass="14321" checksum="4E0400BEAAEF5EEB" modified="2023-05-03" version="1">MSAQRIRVSDREALCMTLRRLAYPNRLCELETMFNRHSSVISSVVSKVMSHIEYYFGHLLADLTVHRWMNLQNLELFSQAVHQKGAPLKNCWGFIDGTARRICRPSMLQQEHYSGHKRFHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QII7</accession>
    <name>A0A9D4QII7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_005774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QII7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="19424" checksum="5AC226204919045F" modified="2023-05-03" version="1">MESELETRVNLPVVQVNRGGLYAVVAVLGIVILACVCVLAYSFSNYAMLKRNAEEMRLYIASRTNMTGQLGGDKPAADGDTAGDGHPPSLKSLEPAAAMPRIILGSGLGKRAKKSHPFLVKSANGTLVMTARQEAFVATAYTQRLGASRGAGGGKTPAAVAAVASKAPAAAYDILVASVNWNDPHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SLU1</accession>
    <name>A0A9D4SLU1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001456">
        <property type="protein sequence ID" value="KAH7932453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SLU1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037332"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041194"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7932453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="300" mass="32856" checksum="8FB9F925997E38E6" modified="2023-05-03" version="1">MMDTSSEPGERDAGVLTPEYMASLQALCRLTKPTLDDITAIFTNEFRAALGDIPEPPVPIDAPSTSRGHPPPRGSRKRGGRKSGNEAFLERVSSHELTGPCGRCIQRVEVDTILTKLEEAVFWDAVHNCAGVRDHFEFHSPHIHFFCREFPGDSVQWARSIATLKGLRSLTLANMRLDKEVAEILGRYLAETTALNTLNLSQVEEAGGDGIVTLLNYLASNLSVKSMEVTREMLEGQAGEALAGVVRRHVALNKLEINGSTFAHPEAVLKAAVKSPSLKTLNVNECRLSTMDIHNMAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SME4</accession>
    <name>A0A9D4SME4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_025652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002291">
        <property type="protein sequence ID" value="KAH7931464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SME4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050276"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7931464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11722" checksum="9D169F9C51B54D2A" modified="2023-05-03" version="1">MDGNDVMNQGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARHGGVKRISGLIYEETRGVLLVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SN43</accession>
    <name>A0A9D4SN43_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_005721</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with KPNB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SN43"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043663"/>
    <dbReference type="OMA" id="LLYGQSC"/>
    <dbReference type="OrthoDB" id="19501at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000005">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041400">
        <property type="entry name" value="PARP16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18084">
        <property type="entry name" value="ARTD15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="17">
        <location>
            <begin position="86"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7935296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="359" mass="39613" checksum="54CDA6489A928B7B" modified="2023-05-03" version="1">MAAPDSPVRSPQNSEDARLRVLEIIAEDVAAADLQWSLFVAALRSYRYDTVLRPFPTSFADQATDTKRIDELRDVAARVPPLGALLPAGSAAKSSTSAATGPKGVPRESWELLLWVLTCGGVRLRSRKKEDVPELNGDSAVDVVFEVEHSLQADRRFEGTRGDREVFFAYHGSRLDNFHSILHNGLLAHMNKNALFGSGTYLSSELSVSATFSPAGYGWQHSLVSPELSCVAMCEVIDHPDVKCQDRARSKPSRAYARDSMAGMVPERYYLVQNDSVVRVKYLLVYTATQPAPPPAPDILPAGMVMRSADRAYYSPGWQDFLRKNKSWLMVAAYAALLCGIGLSSSRVGHNLMLKLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPR7</accession>
    <name>A0A9D4SPR7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPR7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7940149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="642" mass="70343" checksum="64AB31BAF14D0857" modified="2023-05-03" version="1">MAGSGTRRIQWSRRLSLAAACLAAVLVLACLASAFILPPSASSAGPPAALVPAHAPAAAPRPTRRALLHFCTSAQCQQEGQRLNSSIARNQNPCRDPYRYACGHTAHSQVTDLRRGDERRLSALLSSTVVPRNRQTVAEKAAALYQGCLKTELLTAQSRDAWWSVAQRLGVSQFPLPLDKEPPVAPEQLAGHLLRHLGLGPLIGLRLAAPPGNRSAVAIYVHPPPAAASWRWNETASGLQALTQRSPEGQLVRALVDLDRTVARIAAKATPPVATYVPRYHTVRIFSLPQHAKWRWREVFSVLLEDLAAPQTVSLVLTAPGYVEEAAPLLADARPAAVHNYLAWRLALELAPLLPVLPASVALGGVQQRPERRCLRELRALMEHAATALLAPQPGPQGRSAARDVLASATDQLKRQLVDYMWIAEPVSQRAVQKLNALQAHLLYPPFVEDKMVLEQIYRQVPDIGGDSPVLLDWFRARSAVMLKRWKALAGKGLPPLWDVPYMEPAVHYLADSNELGAFHDESGALSFWWERSSFVRLRHAEHCLARHHAADPAEAVLDQVALQAAYALYKQRQQGSAGLRLAALPNASADQLFALAFATGMCAEGDERPRARDRVNLALREWAPFRQAFGCPEERHPCGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQD6</accession>
    <name>A0A9D4SQD6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Unconventional myosin-XV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQD6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033424"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13201">
        <property type="entry name" value="FERM_C_MyoXV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041795">
        <property type="entry name" value="MyoXV_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="184"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="344"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7943300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="75794" checksum="F70C20A7C59B0AC1" modified="2023-05-03" version="1">MVRGMLCAAGQSPDRPRALAEVFRNAASQTRKAIGWLYGVTDTGDSGLFPCEYVAPLSSARPHGPSVSPTSAIGARGDMRSPSEHAPAHNGATNWVEAKDHVDNLEDHAIEQSNGVESHMADGKHSMLQYAMFNFRESLDRYEMLRDQNGSFRGSLKMLEDLKASKKGKDSDWTWKELAQLIKFSKSPIKASLLNLESPELNKLAIDSFLSIMRYMGDYPMSKNQSEVDCVYSILVSCHKIPALRDEVYCQIIKQTTSNKSSKPDSCQRGWRLFSIVAAYFDCSENLKPYLFKFLEAAAYDKRRAYHGTAMVCLQNLRKTFKYGGRKNVPSIEEIAAISAGRNSKRQIYRLPGGTERVINTKSTTVVEDIIDEICGILGVRGSTEMDEFSLYCIVEGDPLTMPLSREEYILDVTTELIKNGHVFYLIFCRSVWFFPLRLDNPLYVELIFNQVAPDYLEGLLLVQPQGRRLPDPMLGDIARIAALLHRAADMQHVPSKDEVKYLLPKPVLASKDVKPPHWVDLVQRNWADMMALTNTEAKAQCLDILQRWPLFGSCFFAVKWIRNENVTSEHILALNREGIHFLDVVTHESVWMYPFSEVISTRKVRAEDGTLYLDMKCGNLMVQKITRIQTDQAHEISRLVRQYINIQQSHQGNQHGGAPQDVTLSRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRQ8</accession>
    <name>A0A9D4SRQ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRQ8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="104" mass="10863" checksum="CD8CF558D362A1AF" modified="2023-05-03" version="1">MNSKDVRSGYTRAGSDNESGVTGETVREADSPVGTDQTDGVTVRELWNAPIEKDRVLTALLERLAPSATPRPVSAGTAGGIAAFQVMPDLSNNITICDGCEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSR6</accession>
    <name>A0A9D4SSR6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_015272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053572"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D-like" evidence="8">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7944081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="189" mass="20998" checksum="E4547B2857B9C975" modified="2023-05-03" version="1">MRVADVLAVAFGVSVLSEVVYFIYTKVTSKKKRRPSKKAAAFGNQVIFFPDRGVACPKATHDDSDTCGNPQCCFLHGRTSLRTLVHTLTSAERALDVCVYMITCDTLGDAIIGTHQRGRAVRVITEAEGSDTPGSQIGRLREAGNHENLLMTSEPDLVDSYAREFTRLWELFKPRPGQNNVERHTAELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STE0</accession>
    <name>A0A9D4STE0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STE0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039589051" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18685" checksum="60053BFB1A0551E2" modified="2023-05-03" version="1">MSVAYVLILYLALVTSMVERSSARRPQISAEELFQKSTSLQSGSDAAVLHGEGPPPTLLDGQSGTAAAVATSSCFFNRDCHAREFCVKPDSGVLTLGVCSLLPDAALARRRGASDHVRDLHFLVRNRRSVPASPPRRGTNDLLRQLLGEENQLARALNSYLHAKYAVLERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUG4</accession>
    <name>A0A9D4SUG4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUG4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033786"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040650"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043531"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="451"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="576" mass="63711" checksum="0E18A69DA5C96F28" modified="2023-05-03" version="1">MRFAGGMPTVADGSVGRAKGDLKALPLLRSLVIGPAARQPVVAMAIRLGIIDQEMAECLTDRFTAPPAAQPALIAITPAPKQPQGHHPAWTVRQIAALGEETILEQELNAALARTKLRSAPSRRHHIPDATAYNDVWQSGTRPEAWLTASVVPVRKPGRASVAIASYSTISLTYAACNLIETIAMERPSWIAGAMEFLPVQQTGFRRHRCNADSTADVVFTLEEARSKAERYPTECSLYADDVALWNRGSRRHLTAIKRSLQRSLYVVASFFKAIGLIVWPTKTEALLFHPRAAAQRAIQRLVLTDRPISQSKALTYLERRIDPSLTWIPAAKLATFKANSVQIAVGKIDSRRSAAAACVIPKTGTTIRCRFLIHSSSTAVELADLHLAPDYLAATTPQLPVAIFSDSRSALQELLQQDRAGITVALLYTKLTAIGASGIIREFLRFEPGKDDVVLMTYPTSGTHWMMQIMQLIVYRGSSATMHSEFCERSPFLEDYGERILEVTTNSHPRILTTHFRPGLLKINQSSKYVYVARNPWDLCASMYDQCRQTPLYPLRATFQELLPLFLQGYVSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUZ6</accession>
    <name>A0A9D4SUZ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="4">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_018951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048508"/>
    <dbReference type="OMA" id="IQEETHI"/>
    <dbReference type="OrthoDB" id="10035089at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="B12-binding" evidence="11">
        <location>
            <begin position="633"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7948167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="771" mass="83964" checksum="348A18AFC2731C6F" modified="2023-05-03" version="1">MLRASQSWRSLIYRSTYVQCSWDSTSAAASSAAGAAAPAASPSPSPAPASSGVDFKFPAEWAKRATKQLKGKPPESLAWHTAEGITVKPLYTSEDVKGLPEDYPGMFPFTRGPYPTMYAGRPWTIRQYAGFSTVEESNKFYKDNIKAGVQGLSVAFDLATHCGYDSDNPRVKGDVGMAGVAVDSVEDMKALFDGIPLEKISVSMTMNGAVIPVLAMFIVAGEEQGVPVGHLSGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIFAFVSKNMPKYNSISISGYHIQEAGANNVLELAFTIADGLEYCRTGLKAGMTIDDFAPRLSFFWGIGMKFYMEIAKMRAARRLWATLIKKNFDPKNENSLKLRTHSQTSGWSLTEQDPYNNIVRTTIEAMASVFGGTQSLHTNAFDEALALPSRFSARIARNTQIILQEESGIPHVIDPWGGSYLMEALTSQVYDEALKIITEVEEMGGMAKAVASGMPKLRIEECAARKQALIDSGKEVIVGVNKYRLEKEDPIDVLMVDNTKVRASQIAKIEQIRKSRDNAKTEAALDAITESAKTGKGNLLALAIDAARLRATVGEISYAMEKVFGRHVASDRMVSGAYKSTFGENDEEISNVIAKVNAFQEREGRRPRILVAKMGQDGHDRGAKVIATGFADMGFDVDIGPLFQTPEEVAQQAIDADVHIVGVSSLAAGHKTLVPELAKCLKNMNRPDIHIVVGGVIPPQDYDFLYKAGAAAIFGPGTRIPVCADQVLELLSGKKHEEKGKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV41</accession>
    <name>A0A9D4SV41_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_015639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048873"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="29"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7951953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="552" mass="62848" checksum="FA2CC72108A65D44" modified="2023-05-03" version="1">MSIRLGIIIASLFATNEPLSSAYKLMKHDPMVKTQSGLIRGFKEEVFGLPIEVFLGIPFAEPPCPVKPWHREYKAMFLPPSCIQPSVYFNQIINITGDERSEDCLYLNIWAPARETTETKEQLKAVMVFFHGGAFFFGSTNWHFYDGSRLAALGDVLVVTVNYRLGPFGFMNAKNPPMSMGNQGLHDQHLAMLWVKQNIRYFGGDDDLITLFGQSAGAISIGYHLVSPSSKGLFKRAIMQSGSPYWTIGKMDNEDSFTKAAIKLNCVDRGVEEVTDFDSVLGCLQKKNASDILNALESRNGRVRLTYHPDHGDDLVPEDVPKAIRSGFANDVDLLIGAVKDEGSVFIEYYMSPVLDFMDWSKIQKGTMDVYFMLLFRFLHEKNVNQIRDFYLESATEDPSSFLKNSSNAMGDFAFLCPLMYFAEDYARRNNSVYFYEFAHRPSYSWNAPWAGVAHFEEIPFVFGFTLDNDLFNITQEERALTLFIMYMWTHFAKTGQVPPINGKTWPQFSASDPSYAELNLPESEIKSPVSDQRCEFWRSRFCDQYKTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVQ0</accession>
    <name>A0A9D4SVQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVQ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF565">
        <property type="entry name" value="MOCA-CYP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="893" mass="99918" checksum="0C72F54AE38142D3" modified="2023-05-03" version="1">MEVEAALILFRRSLERHNLCYTTVLCDGDSRSYLALCMGMEKEDCVNHVQKRMGTALRNLIAKHRGPGLDSLGGKGRLTGDLISKLSDYYGWALKTHSGDVDAMHTAVMATYHHITSNDDVANHTLCPAGPNSWCKQNAAKAKGNGSGGESIYGGTFKDEGFELKHDQPYLLSMANRGKDTNGSQFFMVHVVFGHVIKGEDVVQAVESQPVDNNSCPVQPVIIANCGELVLKRKRKDKKHKRSASNAPSTGAEEGSSGEKASEHKHRKHHKHHSKKSRKDKSHKRDESVEKRADKVDDDAEQSFVKPEEIPEVPANNFLMRRVPDEPNFVPQGRRMGGFYSRRPQISRSGRKIKGRGFMRYRTPSPEGSRSGSETPPHWRQAQARMRPLRDSLDLTQDGEEEAGQEEQLPEEGELANHTEQAANEKEKENRSRRSPSPLDKRRERRDRNADRNHDRNQDRNRDRFRDRREWRDRESNRRSPRRNTQDENQPLPGEDEQPRHRQRKFEEDPRSKRALREERSPRRRSRSPRDRQSRQRPGEDKNSGRSSGPRQHDVLTTSNKERSRENRGRSPQSLPTRASWQETGAGVFIILNKDCTLRRLTGTAPSELDEVRRSRRESASSGGRRGGGTRFIGRNADFTCVGGRLDDVSDRKRGRRIDTTFLTSTDRAQQQKKTEDKISGLSATSASERKLRTLATACEGSDPSAANYGIVDFSAINKLLEMTCTGAKVSSSVKQASKGSSEANHHAEKSSGSAAATGRQTAPRSTSEKGAASSSSTQQGSTTMSRPSRKFEEHPPSSRGSTEAAAEEVASAVLRSRLPLAQLLDPTEPLPPGVEPDECGFFKHIWCDASATIHQQPMAECSLHLKVHRTEAVRPVITISTVIVSFKTIYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW68</accession>
    <name>A0A9D4SW68_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW68"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21247" checksum="536ACF4B04985ACF" modified="2023-05-03" version="1">MSSSESLLSDQPQAHLLTSRQSSAECVVRALLKKSMAAEDTFIEHLPVLSGSASRGMAEVIDAPPEDGASIDPSGRLACDSTDDDGQFILTASVKHECRTDHHKAVCAYGGPDAHRSDGRGREHLESIFVSCSYGTGECGGGRAEATAPNHEGQVSQHDQTRKHASLEEYVPAQSADMHKHALERSTEQRRRNLMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWV0</accession>
    <name>A0A9D4SWV0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14789" checksum="30D7DE6B1349CC1F" modified="2023-05-03" version="1">MGFLSPAVQLAMELVDSDSEDDEYDELVTKVALKLARQSRHRVPRYCEDVQRVATENAFGLLKQRFRRLYFVDANSVKQCCLIVMAACVLHNLCNDERDFFDELEDTTLDDEVGNDEADIMSDALAPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWV9</accession>
    <name>A0A9D4SWV9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWV9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029344"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="306" mass="32838" checksum="BE8A6C5F5241B8D9" modified="2023-05-03" version="1">MAGGRRKFATAHAYGKKRKRRSRIPKAASSGSTATSSATCASGCTTSTEAAAVQAMPVADDTSRTMRVDTLLVSEAEKVAIEHRAEAQRQKLSSLSATRRKQSLIGDSPEAAGCGTEFTLLSLPLLNQLLRSGVEEDFGKLGRLLQELSDFARDCGYKQRAFDRQRKQRSTPPSAAGSDSANSSTRRVATQSLQIEVAADRLAVSTTTFAAVSAAAADNQPDLALFHVYMGEAPAEDAAKRVKAVRKHLCQKLDFQDTFGTVSGGAWRQGPDSTTVFGLEKPKARNCAKVANAIRQELIMYFSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXF6</accession>
    <name>A0A9D4SXF6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXF6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026141"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19749" checksum="DE3A01EE638FEC8B" modified="2023-05-03" version="1">MKRLRDFQRTASQTTEFLWAQQLTVLRSAVVKRKPAAKKPSVHVPEHIPVPPDILQTLSLGPKYAIEPKTSAPQLLALVRHVSCHVPEEEQQRCISEGVDAIARNKPARAQIPIRRVEAFLSDHSLTLVPADKEGGFTVLSLDLFRKKGHEASLSLEGEEIVRGLAAARKKRTTKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXN3</accession>
    <name>A0A9D4SXN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 1 RPB2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_018572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047416"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="265"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="859" mass="96266" checksum="9EF87CFFBC8B247A" modified="2023-05-03" version="1">MEREKGKGSQKRGPNKVKASLFPSGDFIALGSKQRSAPDVPEPKPPVKQSTLSSTSSSTERKRPEAVGASSSLVPSKKPKLAATAAPSSLARLGPGGSQIKRETPSNKSEQWDVIAVEVDPTDFLSRVLKAEDVGDDDKVESLMCGAAKTLKNMRPKPDPMLYLTLMFLAKTRPRIFDSEGSVEAFTSLLKRDVAVNFKTKGNNLISVLACNLLLAAFQDNPDACPSPPAQAVDDDDSLSSLHLDLKESPENVAVVPRFAGSKTNIEHYILEVIHEQLNRRQPMDISKNLLRLLVSACGISEVRSLVAHRLETWLQNPKLTRPAQDLLLTVCMNCNQHNKHDVEVIGCLIRIRLKTKPVVNHFMQCVKELLGQHVDNLSTVLKHCIYNELSNSRNPNNMQLLSVIFSTRQKKQPGEIIRSLRHDLNFSAFCLGLMQERKETQFQELEQPLRERLFMSITDLIVKAIFLAITPAVREAATALFRGEKKDISPLRNYQMQVATIQRDTVWWLHTVVPKMFKPGRNEFLHCLHKAFFLEQLEHYCKDNWPPETDRHLMLRLASDVPALEDTLIRILIIGMSKEHPLNPSDALELVDQLIRRAAAIYKEDSHPVLVVERTELIEIIFHLCAYHHPENITLPAGYTPPNLAIADYYWKAWIMLLIVVAHNPSTFGEMAFASHPTLQSLVEMCITNHFVFPPPTLAVGEKADEIKAREMQIAQVEKQKILEFETHLAAASTKVTITESNSLLLSKLITMDPQGVTRRPPPQVLDQLKALNETLKLGHLLCRSRKPDFLLGIIQRQGTSHMPWLAELVESSEGSLDLLPVQCLCEFLLDEELEGSIGAADPRGRKTRKGQDENSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXP9</accession>
    <name>A0A9D4SXP9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXP9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040729"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13535" checksum="99A83D85D6AE18F5" modified="2023-05-03" version="1">MPRDCADLLGNGQHTSGVYTVFHKAAGTLGQDVYCDMDTDDGGWTVIQRRGQYGHNAYYFYRNWTEYANGFGDPADEYWIGWDAMGSLSGQKFSTYDRDNDLALTNCAATFRGGWWGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXV9</accession>
    <name>A0A9D4SXV9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_000740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXV9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040673"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="358" mass="41095" checksum="DC93DB97948B9085" modified="2023-05-03" version="1">MSKKTCWENGTWFYSQEYEKEYTFYDCGSLEYHRSMTIFSIVLHSLSVIVLVPAIAIFSIYKQLQVHRISLHKNFCVAMVLYDISVILVDAVFILDHVSEEKNIRVNENPNLCKVLYTLSRYFRLCQYAWMFCEGFYLHKLIASAFAEQKSLLVFYVIGWGCPAIFVTISAVLRAVRIGHPCWMDNVEGYNWITLAPGLFCLFANFVFLCNIIRVLVTKLRSTHANEPSQFRKAVRAVLVLFPLFGMHFLMTVYRSPANCGAWEIYQYISKASDGLQGFFVAVIFCYLNGEVLYLLRRSYGRYRLQRGFSSRRGNSLAMTRMSVSTHVTSVGDSLNPNGSVKKDSCPRNGAPEEEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYX9</accession>
    <name>A0A9D4SYX9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYX9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7957455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24585" checksum="D88E1D55BED444D9" modified="2023-05-03" version="1">MVTDPAKKPYDRIREHLMSSRHKKFKTASKEAETAGTSQQTLFDMSCRQRAKETEADGVIHDFVRALAYSGISMHQADGPLGDFARKYCKAAKTMPTGQRLRLKYLKEAFDKDMEKIRYDMRDVKVSVIVDESPDITGVPTINTLLCYYSQKNVKKHVVLVDVDRVNASNSYTVASAVSKALLTVGKTWKDVVAVATDSAEYMRKMVREILRLPDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ41</accession>
    <name>A0A9D4SZ41_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ41"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="117" mass="13061" checksum="B7AFF33316FB6718" modified="2023-05-03" version="1">MVTGLSIRRRQLKPFFMIICSLEGKPAKLFDETDPDWAPSLLLGYSAKNTDPSRHRRLEKRRAVKRQADAKKREAEAQKRRAEADAAALGIQQCADRPLSPHPTGETDADESDTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZD4</accession>
    <name>A0A9D4SZD4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZD4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050781"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15698" checksum="F279C17B2E8B2D1F" modified="2023-05-03" version="1">MSAGKTKKASDVEIQGRHYRIQASVPPSRLSITISNSEHPTPLEKLRPGPATGGDAAARAWFSLAYQSSHLSLSCVVARCPSVVSGNGQCQDATYPEEVRAWIRSEDLKTQRRAVQRLEEALAKQRRKGADDPSNGRGGTRVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZN0</accession>
    <name>A0A9D4SZN0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZN0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7961231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="55" mass="6150" checksum="E18ED97F6229DD8E" modified="2023-05-03" version="1">MQVAEGLIKVRRKENVVEGHLQMQVILPLTIIELPCKSPALTSVSTRKVIGQIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T094</accession>
    <name>A0A9D4T094_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_013813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T094"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057510"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7961978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23931" checksum="E75B7FCD4684D831" modified="2023-05-03" version="1">MDTLAIQSHERQEQQLLQLLREDWPSSSESEDLFEECAADLNANISKNPHCFLELKAKGKPLGRLEIELRADVVPRTAENFRLLCTGERGFGYRGSPFHRIVKDFICQGGAFETSAGKKFGRSAYEQRFFEDENFTLKHTGPGLLSMANMGPNRNGSQFFIMLTKQVATAAFMDGRHVVFGKITKGMDVLKTMASYGTISGKPTAEVVIDKCGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0E8</accession>
    <name>A0A9D4T0E8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0E8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048874"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20355" checksum="FF91346B43B0D243" modified="2023-05-03" version="1">MFTLPFVHIGLSRAAALFALTTILITVVDFGEDNGLSGYDAVSLLTAYAIGDLCSRLITALVLDTRFLSSSATLLSMFVLQAVVMAVMSFESNYWVLLVCCFVTGLSSGGRFFTCTVMVAEEFDEDAISLNLGVMNFVSGIAGFIRPPIIEVHQEPRFLDELPDGPAVGSSSMGTRAGASLELSLVLGHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0H0</accession>
    <name>A0A9D4T0H0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0H0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031103"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9421" checksum="CB7CAC278CE0E742" modified="2023-05-03" version="1">MRPRSMPTHIVADGEMEKSVAVPQGFLTEATAPVKVTVRTDNVADHYNVEPRPFASTRGSQSKVPVKQQKIWNGLERDPESSCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0P2</accession>
    <name>A0A9D4T0P2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0P2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028800"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="170" mass="18835" checksum="35E6F23B090D3ABD" modified="2023-05-03" version="1">MIDIPAQQHAFGAKAAAATKLCWFEDHETSDREVHLESLGLRKRSKETYALSGLCVTVGQQASSSALALNGASRSRLFSRDRLNTTDYMHTLATLDRRLAMDEILEKRRRAVFLQQIRCHAPGDEDDVFLEEGLFCPEPATSTSSSRHTPNNVDDTASTSRMQHGATSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1I6</accession>
    <name>A0A9D4T1I6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029684"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032088"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040260"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="922"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116305" checksum="34F740666A6B76E3" modified="2023-05-03" version="1">MATATVVTGYDPTSMQVLTMETSSADYVMPSENEYLEDMVNTWKRKKAKSKPASLPQDAATARRPTDAACTSAPSPPAKQRKWRPRQTPRLSRDDYIVVLKPRVPCELRTSVPADRVGDAIRAYLGDQTTAQVQVWPIWDQNIIVCSTTELPKAQKLLGDFQLPVGDQQLPVRGHAKPSGETCRGVITINPAETSQKIKSELHWPQGTILAARKLGDSAAAVVTFEGTKLPRFLFYHCVATYVRPYKKTVSACTRCGTIGHRPSVCPHPNPDRCAKCGTLAAEGLTDHDCHPKCLLCQGAHETGARGCTGKYRTFTPTSTPSPGPTPSLHNKGARPKQPGSARPADTQEFPPLAASTAPLQVSGWAGVAAPGPLFPPPAAPPSPELAVLRKQNADLQRKIALLTKQVASLQQGTPQVPGPTVPAQTAPPATSPKLSPQAAPTSNTPTPSVATASFPVASLAPGAPQAPVPIDPTLSIEERVPRLENLLLHHISTFSVQRIVAEVVQAIQAWAITQFKPKTSRSRSPSESGSAPRRRKESGPTPTLPGYCPYVGGTTTSLLVHKAYTAIQIDLDLHLPYDYCMVSVLPQRRGQPSIHILNVYCPPHLSRVSFTQLFHQALCTAARQPLVIVGDFNAPSPHWGYHYEKTRGRQLKELISSLSLTLLTDPAHPTRSGNSVSRDTCPDLSLTRNIRDATWENLDETLGSDHFLLRIAFTPRQKMRHHWGQARLTDWTKFRSQPFPLIPNSGEYAAWASHALHTQRAHTQTLATTNERLQQAALLVDTYAASCGLECSPTKSALLSVSRLPSPKIFLPSGPVPVVQDLRILGLYLSGAPKQLYNVRSEEAPKMRWLALLAIVACGSGRGATALSFAETEPPVARPSEDFMSDIVLPIYPARDTSTATPATMPATTTTAMPPAPTRPTSTCEHGQHMADSKSCSRFFVCVHGRTVSVQCPGPLLFNDRTGVCDWPRNVRCANGRPNAAEAGVGVAMDHWGDVKCVASEGFYASPRDCAEFFRCHRGNAHRFACARGLVFNEAYKTCDWPWNVKRHGTGRRVWRVCRFRKHSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1R9</accession>
    <name>A0A9D4T1R9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_010653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1R9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="129" mass="14426" checksum="D21AB750C9EB4C55" modified="2023-05-03" version="1">MNENKYGVGTVPYHCVLHGLVKVPKPQDVVARRAASIGYGELRCLRLLQPHKNSPNDENFQRVGFYVVPKVISGQCAKTTELSSKRRALWLSRIRREDLDESATHYRVCGAHFITGERGSSIKCVSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1S6</accession>
    <name>A0A9D4T1S6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_007860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1S6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037927"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="396" mass="45185" checksum="958EC0AEE4B41C5F" modified="2023-05-03" version="1">MYFNSCRALQERIQRPRVAVVTCILTPHRVIGETMKECSFLHCDVAGRPYLLEDFREPLQELGVLKDVTGIGPFQMTHVGLIKLRTRKAKDALVNAGGLELKGRFCAVIDPVQQDTTLKVHWVPFHVTGEALTKAFDHYGEVKEIRQEEWKVRGFEQAESLVALCSSLFPEELQFVFVVDVKDILDETAECQEQGSTDAEKVVTPSASTQDATTGRKQKNRRSKEEEKTAPAPTVLDNGRDAQNEYFNVEPETPYETPDKMATQEPATPAKRCRRDATTVDVTVEETMVDSAQRLEPQWMEVRKGNTAQREGHRRSPEKGRRRSDQRDRRRGCPFKLSCQRRRSIQTSAFLGATMATAEYSAELLINAIKMYPFIYDKRHPCFKDRTKKDQAWAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2U8</accession>
    <name>A0A9D4T2U8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_022612</name>
        <name evidence="12" type="ORF">HPB52_024737</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000292">
        <property type="protein sequence ID" value="KAH7986761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2U8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045614"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050590"/>
    <dbReference type="OMA" id="PRWATEC"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7969901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7986761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="31846" checksum="834543E81F6FE5BF" modified="2023-05-03" version="1">MESQQANILGGTAAGGISWFPQRDPRTVGWPLTGSALPVAIITAAYVYFVKVAGPRWMSRRKPYDLRGCILVYNMLAALFTAFFVVRFAKLAYWDRGYTFLMDLDVSNEPSSLEIVRLSWWLYLFKLSELTSTVFYVLRRKYEQVTTLHVVHHVIVAWNVWINVTYAAQSHTMFVVCINGFVNVLSYLYYFLAALGPEYKKWLWWKRYLTMVQIVQFVLYFVHAVCLLFAKGNYVPLFVWLEFGQAALFFSLFVLFYVKLYTKDKGGPCGPVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9G1</accession>
    <name>A0A9D4T9G1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9G1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33666" checksum="C206528C0FB1C5A7" modified="2023-05-03" version="1">MDASHQDTPTADAHQLPSGSSQEETMDSHDMQDTTTPEEDDENISSPWIEVTRRANRRSPPPQRHSAIALDETPPKSALRRGSGPRRPKQPPLPMEDYKVGFRPRNGLSLAKINPMHPTAAIAREAGIPNNPKPFQLRIDKEQNVIVASTPSPAIEKALETLQKNNVGGNTYEVAVYPVAPDNSCKGVIYNIGTDCSVEEFKAVIEAPGYEVLCLGRLRSSSALVITFKGKKVPFYIYVHRVLTRCYLYKRTLAYCTTCHQSGHRADVCPNPPETPKCKDCGVTLSGGQHECHPRCGLCDGAHTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9R5</accession>
    <name>A0A9D4T9R5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9R5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15610" checksum="C5927F6E0BA0BD18" modified="2023-05-03" version="1">MDAAAVALLDLHCNNVSPPLLHRRPRRVSATAVVRLSIGRIFRAVLRDAVPAIAVASKDTSARCAAQREPRWRFRTVMQMNFQWDKDYLFFCGKHASSSGPYFDFPYYDDPCSVRLPVLLMYLLLPCYLEMSILWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TA78</accession>
    <name>A0A9D4TA78_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_013367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAMHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TA78"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038474"/>
    <dbReference type="OMA" id="PRWTHEA"/>
    <dbReference type="OrthoDB" id="6475480at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="3">
        <location>
            <begin position="78"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="508" mass="57463" checksum="602BFE7078A944DF" modified="2023-05-03" version="1">MGNTDGSESRERSDATTDDSVTPDLRADVLPPRKVFWDPVHGQISLHPVSVAVIDTPEFQRLRHIRQLGHVAYLYPGASNSRFEHSLGTAHLARVLGAHLRDCQPELKLSDKELLCLELAGLCHDLGHGPFSHFWEHFYRRGARDRGLKPRWTHEAMSCKILAHLIDVNGLDRTFSAWEAKWPGQGLTADDVKFVQGLILGDTNGVEPSRWFLFQVVNNRDSGLDVDKWDYYLRDCHAVGLACGFQFQRLVGSARVVEHEGFTHIAFRDKELNNVYEMFRMRSTLHNNVYHHQMISIFEAMICDSLQLADEKVASANGGGRLRLWWTTHEAGQPDASPQQVEAFVALTDAWVELSVRRADAKQQPEVLRAQQLWRALETRSRKPCPLYRFLGSVPKSDDGGVGSSEETLREAIMAALPEDVKPKVEDLVVDLVNIHWGCGEDDPVKKVLFFRKAEPDRALSAEQLRVQSSVLPSRFQDARWNVLLRAPGKPGLDEHVERCLKALQLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAB9</accession>
    <name>A0A9D4TAB9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAB9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052731"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21011" checksum="81199F105DC7B0C2" modified="2023-05-03" version="1">MPPPAMVARGCPTPPRKNKCWTFAATKSTLVLDGCIKTEPEREPVQKTVSSPSGMTSCRDPWKKGFCEDSNSKWLDVTTRAMLDVLQRKHTVLVIQRKGLLPPSGSLKRNGVKYRFMVTETIGEDPLKQTQNHEAGNRNAPRLAKKNRSARKHPLRSTSCQIEPSVSVGKRPKTTVKKKKVFTTESMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAC1</accession>
    <name>A0A9D4TAC1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAC1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="101" mass="10883" checksum="E5D3C8D161246FDC" modified="2023-05-03" version="1">MGRPNPLAVGAIQGGGYPADGPPPARHKEKGPWHLGTKHDGRDKRQHRFGKGSRFSWVRRAAKLGSDGGYEAAARMLVEKTGRANEVRRGGSSGYDAPRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAL1</accession>
    <name>A0A9D4TAL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAL1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10059" checksum="A047104CE62F8714" modified="2023-05-03" version="1">MPVLAVLATQWMTAGKGLGTGPTKTWKMRCTWKMHANDAVATNEDLTDEAIVAAVTGAEDDSSDDEEEPEPMQVVLHQEALQMIYSLCDFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBV6</accession>
    <name>A0A9D4TBV6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_023279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBV6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049766"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="303" mass="33171" checksum="250D1702AC68EA10" modified="2023-05-03" version="1">MTKARLRHCYAPGCRTGYAGVKAERKLSLFSVPKDESRRKIWERNLHRSDRALEENCAVCELHFEDRYILREYVHIIDGKEVRIARGVPALTPDAVPTALPNAPKYLNTKLPTKRAPRKREAPTVPGPQNSKKACTSTPVDEDFESQGDVQDVSTAISHIRIGEVHASPAGAERLFYFETPAGGAGARRLAVIFCAAGRTREATEGDLGCESTASVARERGKESRGRVLTCGPAARPSRFLEGKQRKDERCELREARPALLTSPRAGPRSLESVKPGEASPDTGPELASGTFPFPDACAPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDE6</accession>
    <name>A0A9D4TDE6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_025182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000568">
        <property type="protein sequence ID" value="KAH7986154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDE6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7986154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="610" mass="66130" checksum="B2A35DD7152F33DF" modified="2023-05-03" version="1">MSGSDASVYLSAVRWDDTGVPLQEFLQKFPEPQVARVVRGQHRHVGVPSLSSPGLSSVVFLSPLGARLRISAQCVKFKENRQRVVAIGPRLAIPEGYRGWFEILSEDGRASRCFESVAELMRRSPDTCLVREPVKAHLAHPDNPEQVTDKTRTLQVGETLVVVKEHTSPMVRASLARLRSSAPHGRFLRCLTSAGETVYLAAESRGKFSPIAKEGNISGVHSVKRCSASGLKTSELRLYGVEREECVLALPLVKDAPALSLPESAPLRLQPPKNVDALVQMPEYTRLTEKSKRLQDRIDAIEVLETTRSSSDFFSSKTPPQRSLSEPKGKPTPPPQSPPATATAPPTNGVERVQSMPAPDDYRYEEIDQIYDYVRGFAPLPDKIKTELIQGVGDGNSECEKSSPSSPSPPGAPATSVTSREKPLPPPIETIPARRYSMATDPGPNSPPTAAPALKSPPIVRAKDTDSHVYEAVMRRCSDEHKSKGGSVARRVGRAPPNNKLFVKSSHQVRNGSAKPRMFRNAGRIPVAAAVNTSVAPPPPAIFQKASSRTPRTCRGAKPVNGTITTSPLFNIRYKSLTNLAVDFNDTLDSSNSGAVAAKVSEQPLLGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDF9</accession>
    <name>A0A9D4TDF9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_025171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000568">
        <property type="protein sequence ID" value="KAH7986143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055718"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="13926" checksum="758B5B728384FB73" modified="2023-05-03" version="1">MQIYSGPTHDERPGQLLRRNLRVTEDDRHHSFLEAYLTALTHIRSKELHSVFFGGSGYFTQSATEAPRSAACAGMCAKGEPGARYRCHVVASSSPNFARAFGCTRSNRLIPKKHCPYSNRKGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDG8</accession>
    <name>A0A9D4TDG8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_025167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000565">
        <property type="protein sequence ID" value="KAH7986159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDG8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="186" mass="19969" checksum="DCF08723917F71FA" modified="2023-05-03" version="1">MTSISKGTSAKETSRIKDLNPFLDVNNILRVGRLPTDIASAVTAQDLGQQLQAVQWIETALARQTRKDALTGPRGDSLVENIGFPGDRRREKAPRTAENTSKRRRKQRVFEPSTTVAPAAPRPANTTVTAPHPPPAEEDFVTVISKAAQRRAKALAAAAIATDPAVAGTVLYRPSAPGGTFKDRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQD5</accession>
    <name>A0A9D4YQD5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_016644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053405"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058897">
        <property type="entry name" value="PAPPA_SD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130:SF3">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_33, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="LAMGL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25900">
        <property type="entry name" value="PAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038536950" description="Sushi domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1175"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1358"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7984058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1545" mass="168781" checksum="FAEB1041F79E9E1A" modified="2023-05-03" version="1">MRAATALALLWTTMCGVTLGTSRERQQASALRERLERQAWSRCSSSAGSAARAHAGLVGPAVLETPPRVPSGGERQTRQAEPGSETVNRAAYLVSATGTLVAEGTDAGRLPWRHFSVALWVRPEGGQLREAVILEARDVCSPLSSKRWSLQIDGDGRDGERSGHFTLHLQAARSQETSVLRSPVPYVPGRWHHVAVSFDGTHTRLFVNGAQVAVSSKQKGSMFQKSGSSCRSLSLGGTRSRHYRGLVDRLRLWGRGLQHAQVHRDLWQPEDAQGALIVDHFESLDQWEWTGGAAQLVQTPTPGRLEGIQLQPAPCGFTVCDDPDMVLSYQRHWSLRTPKRLRYRVVNVKNSDGSNPTVTEEQIQRQHAALNRAFEPYNITWELTQASVLNSSLRRRQVTLGCPSYNLGDGICNPDCQLVAGDGGDCDPPLESCDPAMVGDGTCHKACNQAVNSWDGGDCCLSSENNGNCLDPASPNRSYIDVKEYKELLGLNNTMHINILFAHWTDKDIIGIATFPWDKDVFAVLGGVVVQPEQFGRPGSLHTLVHELGHVLGLWHVHRGVSEVECHDECLEAHASLLTGDLCADTRPTPQNYMCQDPAATAARCALSRFKDTPFHNYMGYADDSCTNSFSAQQAARMHCFADLMYGGWQRMDQAFRPGQPPLAPAPVAVDGRSVTLSWAPPAASAQRGECAACDDNRSLTQFASRAADNAGPRDSWEAQQATGPPDAEACTLSYNAWLPAAESCDDPRDCTLSLEFEHNVVPSALSIWLPWNSRQGLRELVLFYADGSQSVIKGVTAYCDMPFTMPLHADKELVKIHAVAASPMVAVDAVQVTSAANHASCATCKPLRYRVYRKPPFSSADSKLSDGLRFTDTEVEEGAVYRYEVQAWMGSRSSEFSPAFLYTHGQGFCGNGNVDPGEDCDDGNTCPGDGCDPKCHFEKKFMCKGNYCSILKGSPSMCYAYEDDGICEPSERERNVRDCGFYTPPGFFDQWASSVHIAEDMLMTSCPPEAILGPPPKDQACVCGRDLNTNHSWHPCDVPEASAYTLIVSFERPVVAAAVQVYIASEGLATLSLPLLTVELLHDESHGEGGHQTGYELVDSRRVSCRANPIELPVVHDLTQPFRLTSSVRINLTAPDVSIGAVRLRSSRTLNPVAVSQCSPKELYHPALEKCVSYSCERPRCVKPAMRNARLLCEGEEEGDTCVIRCDEGYVLAGDDSGDRLVCNGGTWTGSENLCKPVDCRTPLIAHADPMCADGTTFGKTCSFKCRPPARFKGSTGGLANIVCQKDGRWSEPEHQCHVSCPAPSAPPHAVMANCRGSDQLHFGHKCRFHCKTGYHVKGHANKKYEWTGFLPSCTPVACPPLPSVYTGLYSCTDFWYAGSICTLTCPGTHSTAELRCELDGVWNRDPPVCSFSHLSCPEPRNRSGVVHFRCATRSVGSTCNVTCDQPDYEPVFTQDSRQLSLAQAVVCSGAGLWHPDTDSLECRRRCNKEYIGDGWCDASNNQEHCDWDGGDCCASTVAGHVVKSFPPNCPVDECSCKDPRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQF3</accession>
    <name>A0A9D4YQF3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_017073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029027"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031444"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7984102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29923" checksum="D3151EBA5C0AC399" modified="2023-05-03" version="1">MPNRCCTPGCRFGYKGTRKVSLFSLPLDKLQRGKGKRAIPQQESGDFNFESKYTGVCANHFDASDIVTTHDFNINGDYVSLKRDKPTLKADAVPRIFEGLPSYLTKRKPRSRSSTMRPPCKRPRESSCEELRALPTPCFYRIGQLDALDDAYEQYRRAIESRGEGHRGSQAKQRAWETHSEFIRCVGYCKNGRRGKEEWVRCEERRQGMSRATTGGGPEDVAPLDDLEARVANTLDPEAVFGVSGGLDIGAPTPDPADQKLICHTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQV0</accession>
    <name>A0A9D4YQV0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQV0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028986"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF30">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30930" checksum="DA240EEF238BF732" modified="2023-05-03" version="1">MAPLNNPRAYHGLAVLDENIYVVGGVDSANRLLSCLERYDKETDEWTKLSGELYSPRMAMGFCSHKRQLWVAGGIVQIGRRTCSTAYVEVYDPKTERWSFAVNFLPSPRSCLTLVECGDDLYAVGGLLSHRSGKRRIFTTVEDTLVFVDERNTWVNRAPMPNARHSTVAVAHDDMILIIGGRQAERPDFHFDNILAYDTKMNKWYLLANLPRSVVDYHCVLAPPEESSESLREVLTSRGDHRSTNKLVEKFRVAAPDVKSYSQGDIAIVRQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRM4</accession>
    <name>A0A9D4YRM4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_025160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000562">
        <property type="protein sequence ID" value="KAH7986168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRM4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23256" checksum="612F6BC33D3F0ACB" modified="2023-05-03" version="1">MPLSSHLQDWACKDGHENQQAFQPKSNARWHYAAPLPQNYAHLHVSLTTTFATIEADQCFAISALPSRADSSPPGRHHSVVAANLQDLPPPHPVRWVHPVNSPFRLTVADSARAQAYLCITSLTVSGTTFTVHLYAPPPEDALRGILSYAFDDFKDEAILEDLQASNPTLSIVGAAVRARLLTFWSPSTNPRYSGGFSSMVSTFVLFLSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YSB4</accession>
    <name>A0A9D4YSB4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000118">
        <property type="protein sequence ID" value="KAH7987112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YSB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050813"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7987112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="14993" checksum="E81F0E85686E2F03" modified="2023-05-03" version="1">MYQADAEVTSGGSSDSPALQVRSDLKASGKCQPSGRKDESQDNKGQDVPGAEASMVRPKAVATKVEAPRSSSGVDATEEPVEGMDLTGASSKRPRDPSKGGDGREGDDGSCEGPPPKATLPRRATLKPEPNIPPDKRNSPLAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PA89</accession>
    <name>A0A9D4PA89_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_025230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001934">
        <property type="protein sequence ID" value="KAH7931842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PA89"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028688"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7931842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="11889" checksum="DD0F7146B16EB59E" modified="2023-05-03" version="1">MTVRDNILFGKTLDVARYTRVLDACELLHDVGRFPAGDLTEVGEKGATLSGGQKQRISLARAVYSDSSVYLLDDPLSGLDVHVAVKVFKRVIGNNGLLRNKVNIMTVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAJ0</accession>
    <name>A0A9D4PAJ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_004798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAJ0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033960"/>
    <dbReference type="OMA" id="YREEDEM"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="70732" checksum="D0C6B2009773EC41" modified="2023-05-03" version="1">MPGRKSDAPAIGIDLGTTYSCVGVFQHGRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKAQTAMNPENTVFDAKRLIGRRYDDPKIQDDLKHWPFKVENDGGKPKISVEFKGERKRFNPEEISAMVLTKMKETAEAYLGKRVSDAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLRGEKNVLIFDLGGGTFDVSILTIDEGSMFEVRSTAGDTHLGGEDFDNRMVEHFVQEFQRKHRKDLRKNPRAIRRLRTACERAKRTLSSSTEASIEIDALFEGIDFYSKLTRARFEELCIDLFRSTLEPVERALRDAKMDKAQIHDVVLVGGSTRIPKVQKLLRDFFNGKELSMGINPDEAVAYGAAVQAAVLSGDSSEAIRDVLLVDVAPLSLGIETAGGVMTRIVERNTRIPCKTSKTFTTYSDNQPAVTIQVFEGERALTKDNHLLGTFNLNGIPPAPRGVPQIEVTFDMDANGILQVSARDNSTGKQESIRITNDKGRLSKEDIERMLAEAEKFKQEDDAQRERVAARNTLETYVYGVKQAAEEAGEKLSSTDKDTVLSKCRETISWIDANSLAEKEEYEHRLKELQQVCMPIMSKLHQGQGAQGPKHGANPSQSGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAY5</accession>
    <name>A0A9D4PAY5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_006751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056811"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="238"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7935364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="487" mass="53880" checksum="C93009CCA0B674F6" modified="2023-05-03" version="1">MPYKSLNLPAISDADRACKDALRPDIVDNDPTYILSPNFDGINRYPAGALCMWTLRTPPGKVINLAFEEFSLQDSLDCVRDRVALYAGEWRPQPQQRQQLAEKQQNAVALGSAIEEQGSANLLARWCGPWLPRDYALPPNTAATLVFTSGRLGTPGLGFVARYYLTDAPVKEHCKEEELRCRNGQCVDDRKRCDRNDDCGDGTDEENCGPEVNGLGSETCGRPLAEPFRFHVDEDAYIVGGSKAKPETWPWQASLKLAEDPVYGHKCGATLVDRQWLVSAAHCFRTWGEPSDWVVYVGKYYLFEDESTQQLRYVESIFIHPGYQMAVKPVLVQNRKDHDIALIKLNAPVTLNGQVQPICLQELPDLADNTTCYVTGWGATREAEMSPVLKQAAVLVLPLDECASYYNGTCVINQLMYCAGYEDGRHDSCHGDSGGPLVVKQGGSWQLAGVISGGLRCGEPRHPGIYTKVTPHYSWIRGVMAGNVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB58</accession>
    <name>A0A9D4PB58_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB58"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056715"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="245" mass="27671" checksum="00D70639D890531A" modified="2023-05-03" version="1">MEPSEVTSESDSLLPNEPCVASMSTPPRSVGKNKSGHILNNNSQNMIFHCYTYWRNREPERSVEDTSKFVAEMLGVSESTVFKVRREAKASSSSGGNLSTPSRKRPRNAEKRRRSTKYDSFTLCALRSSCVHDFFRRNEIPTVEKITNEFSNRMDLPSLKRCAVRRLLAEIGFKYEKRCRNSLLIDRDDIVEWREAHRESSRGADEASWESSRLVLGAASMFENAGAVLPSLLCTAMSDAATEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBF4</accession>
    <name>A0A9D4PBF4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050632"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7934776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="251" mass="27373" checksum="07857C8097D0B6CC" modified="2023-05-03" version="1">MADEGQTPRYSTASSGSNQAAQETNEASSTPDNDSSDKEWNDMLNDWYEQTIGSPRIAPTSGATSNFEPNMEYYEADDPFFSFDVYDNGSAGVPYPTFSRSDWDKVASRSRTGIEQPSATPENYTSNRGGTYNVKPVPEHGEASHVSTYTTATGMNGLPVPASSDGAYNSDPSTSHEGIEETMQGCDASQPGDSAEALTPRQGNPADDKPWVCSFYMEEFTCAADLKNHNDINVTDRIHRCLACSKLFKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PCY2</accession>
    <name>A0A9D4PCY2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PCY2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7575" checksum="B23E39CEC161888D" modified="2023-05-03" version="1">MSEEVIAWPDQQQRERNKAGFLAKRAGKGPRSIIGCVDGCLVEINTPSESAHSYFNRKKFPSLILQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD55</accession>
    <name>A0A9D4PD55_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_002183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029250"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7938895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="14964" checksum="023E56B46CE0F376" modified="2023-05-03" version="1">MDNLHVGDIVIFIVLTAAGYIVGLYFSFSRTCCQAATSDGGAPSAVLETFLGGRTLPGVALAVSVLASVANAVGVVSFVGHYYVYGFNHFWALTGIPLAAAAVSLVFIPLLYNMRVASVFEVNTESICFSLRFVLCCYGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDE2</accession>
    <name>A0A9D4PDE2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_021559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDE2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7936353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43884" checksum="C3E019CE503F0337" modified="2023-05-03" version="1">MEIVDGEAISPEEANGPGWITAYNRKPSKSKAKQPQDARPASTRGRRRNGGRTTGPRGAYGRLVATSRLPQLPRDTYRIIVRPRDGLNVAKITPVQFEQSLAMAAALAPQDLTEDSICPNVTQNIFVVCTPSERNARAYTTVQQLRLRDTLYRVAVYPAPPDDTCKGVIRGIDLDLSDNQLRELIVKKRNPSALEVKRIKNTPAVTILFQGMQVPNYVYCGASIIRCTLFRRHTEVCYNCGSLGHRADVCPNPNTTWCRTFGLKTPPENHQCKPHCTLCGGPHPTADKDCKRKFQVPYIVRQRRRRRRQRGRSRSRGPSGASSRNSSATSSTSAASRRSRSVTPAARRRSALHSRSRSRGRSPSRLAGLTWADRVQGKQQSQRSPPPTKQGLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDS1</accession>
    <name>A0A9D4PDS1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDS1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12259" checksum="295DC4732C018414" modified="2023-05-03" version="1">MEATYFNRLLRKYWRRSKKAFFIDHALQWLPLTRVLAVHDLFRWAPKSVPCGCCTQFRFFKLRCIPGKIGLSLPPPWVIATLPAETPVEGAPPTDDRRQRLVAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE49</accession>
    <name>A0A9D4PE49_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE49"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="147" mass="15906" checksum="D4E16CA847218F10" modified="2023-05-03" version="1">MTNHQKLSTGKQSAVQEAHFVVVVHRQTISRKLESLAPNEIKDVRVNPRKNVLAIDVIHQASLLALTRVTDFDGIKTTGMSYAAAVGALSKDPCPRGAQQREPPAGPKKQGSAKLRPPTKATSQPHADQENANLRLLLRAVADLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFC4</accession>
    <name>A0A9D4PFC4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFC4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14663" checksum="054A9216B140BD8A" modified="2023-05-03" version="1">MQTATKIGCECGGDYRSRVEPAPIVEHKRAKKTHSNNRINKLLHDHAADLSSTFNNLASKHMPPPTQIPMPDYVGAPNEELGRPITEAEGMSTAPGPDSVTNKTLRNLNDQSISKLTEYYNHCLEKGEIPQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFE3</accession>
    <name>A0A9D4PFE3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFE3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027421"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34120" checksum="F5B9A349B5CB6F74" modified="2023-05-03" version="1">MQRRVVQDQTPRQQVGGFARRPREHSPANSERVIRRIRIPPIPKHMHPKNDHERRRARAIALTKNHRDDPHAYYVDVAKYPHMKNAYAAAVLRASTGKITSAGSIRCKTPAQAEEYAIALAMHTTGCHTILGDAKTAVINYSHDSVHFTTTRSEPATDPDSEDVNYAITQYGEVLQWYRTSHIKYPPPHRDLTRNEATTLRQLQARAIWTPVLAKHICPEIYHTDTCQRCERARATQNHVLWECLPPPPNTQNGQIPEEIDKKITSEEYETQRDTVRHVLELLDLQKPGTTDRSQDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFN2</accession>
    <name>A0A9D4PFN2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFN2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7938986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12855" checksum="27A74C9B5D6294C5" modified="2023-05-03" version="1">MREQLAIPAIRVIQGLCHPRQINALNYDDAGREAVTDGLRPGPPVTVRTVENVEKVPEKLSENRCHSVGVIAQDLNISKDTVRKIVEQDLEKKKIFSKFVPHSKRRLGIFMSGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGA7</accession>
    <name>A0A9D4PGA7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGA7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032561"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="359" mass="38834" checksum="48EA3874D5CEC83D" modified="2023-05-03" version="1">MIPARGAGPPGPPPTKPPELQPGTTPDQPQQMLAAVTNIGSTSGAGLQPPTATGQNYTPSFANLSLPPGQGPPMETISCLDVNLPEGQDEDFSDTSESSATITYMDATAISSDSEKHIDVPPVKRCRGSKRSLMLPNSLPAENTPKPNLTIIFKPRNPEQIITGFNPLALKTAFEEAAPDGVLQVRPNERLNLLAVDTRHAEASERLLKVSSIAGVLVQAYEPRPANCGVGVIKGVPVDLDQADILAALLQRAPVRSVRRLGLSENVRIVFVTESAPEYVILGYTRYRVYKYLQLLTYEVLRIAHLACRKSHGPQLLGVDHASAALDKTMETYTHCYLRLLTLCAASSPQCPLRWLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHP3</accession>
    <name>A0A9D4PHP3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_018107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHP3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="16486" checksum="CAB80008EAB6030F" modified="2023-05-03" version="1">MSQHSRGTLVHTCRTVQKWRIFKDKLCRVSSLEHLYLLSGAPLPDKDVVTPILAKDYGEPVSDKDVVVSLLALSSRLPRLSFVHVHYRSVEAGGRNWRMTWMRRAADHPQDDYALSENGPCFQGCSTATFIGLAKPLNRDFERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHS4</accession>
    <name>A0A9D4PHS4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Corticosteroid 11-beta-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHS4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055321"/>
    <dbReference type="OMA" id="SWQDTPE"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7943290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36074" checksum="C72B462B533346F5" modified="2023-05-03" version="1">MVAEENGKPVKNGSLKKSNGSQGNDVVKKAVFITGCDTGFGHELAKRLDAAGFQVLAGCLNPSSEGATMLRDFCSASLRVLHLDVTREEHFRRASKTLAAELGPRGLWAVVANAGMMSAGELEWGSLDAARYLFEVNVFGVVNTVRTALPFLRRQPGSRAVIVASVAGRLTYPGLAFYCMSKHAVISLADGLRREMRKWDILVSTIEPVLYRTKMAMPEHIQCTVDQSWQDTPASVRDVYGKTYFEQFRSRCLDFLSRRCREDLYEVVDNMVHAVSSRRPRRSYFCGGAKDKFRLALLRLLSVNTVDRLLCSINQSHVGRSISDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIH7</accession>
    <name>A0A9D4PIH7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIH7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034568"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042496"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="271" mass="30501" checksum="988A833E3E98CFFF" modified="2023-05-03" version="1">MGIRTNSTQMFPPDGLCEYLFYDSLYKEGRNTFDAPDQFDTNLRTFVDIAPTYKTTAFGIGFSYNSAFHLQFYLRQQVTKKFNVMQHFWDHSIYHIGVLDSATVDPREVDIVPALNCLKTTAAESIVRLSGLKLKSALSVTLSGHLAVLTDPKNRGFLAPCMTNNSVDSFASYAEVCKSPNYTSPATYDPSVDAAQFRHAIEPIVFSYDDRKGLNKKLCAIKEEHTITKFGIAVFDVDYADFSNVCKSRGGPFARLRLVRSVLNFFRTRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ18</accession>
    <name>A0A9D4PJ18_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_002740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ18"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028886"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038669966" description="Single domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7942965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11350" checksum="849D7504C23B1E16" modified="2023-05-03" version="1">MMPSVFAVVLWFVGVYALDTTTPKPPGQGEGQPPFPGKCSYGGLMLEPTTLNLMKEPCEAWTCDAENYTITIQRCGDFQVPQNCELEAALEAFPSCCPILICGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJ90</accession>
    <name>A0A9D4PJ90_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_017514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJ90"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049961"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19387" checksum="DD9958E7CFA31EAF" modified="2023-05-03" version="1">MATRFKPVTHVIFDIDGVVLDADKVYAAAVEEVAGRYGKTYTWELKKRVMGMPDTEAARIIIDALGLPISEDYYLYELDRLYKLTLCFSRVMPGAERLIRHLRAHGVPIAATTGCMPLSFGQKMRHHRDVLSLFNHVLISGEDSEVKHGRPHPDIFLIAASKFDDHPAPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJA5</accession>
    <name>A0A9D4PJA5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJA5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026351"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048320"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136239" checksum="8979E5E20C6872F4" modified="2023-05-03" version="1">MDNLPRERDQLSLSNFAERGDTSATVDRAEADRYRPPCTAHTDQVCQINNCLPHCNELLFDSGLKLRQQRGGSFTLESNHRDLTPRRGPDSYRATPFLRWLLKTHTCITALELSDDSFKSHSKVVLQELPDDSRIKNLTLHLFDDDNTHTYLTMHLPRLRSLEVLSCSAGCAGTDAVAGVSALLRTTKSLTCLVFHGSFGFRQPPNALIDALATNSTLKWLDLTTYWETDKPPGPLGEYVKSNGLLTRLTVSGLDVDREELLLEEALVCNHTLSTLHVLNVCGGESVSDLDIFTNGLFRYNDLLTHTIGHSRYISRVSFLENTGFGDATNFVSLLSENIGDNHVLLEVDLSGAKVGGEAKRCLFIIRETTQRNCDILERAAANIERAPLDWHTATAFEKVARSPALIRELSEKEGIATAEVARMLRSRLRCVEGLHDFMRLTGVVKDSVKCAPSVEGRGMQLPDLSDDCWRLVRRYLSFDDVKRIHKPCVSWSLAEATIRRNTMENHPAKRARLSTAVCAERGDTTGILDRGVDQYRPQCTVCKDQVCQINTYISNCNELLFDIGLELREQRGGSLSLVSIPITALNLSSTSGTNSYRATPFLLWLLRTHVCITNLELTDDYVKSHSEVVLSELPDNFPLKKLTLHFFGRDTVHTHIATVLPTLRSLEVLNCFIRCPSSDALVDAVSALLSTTTCLTSLAFYTSVYKIQLPKSFIDALAANSTLKTLHLGTQWMADEPPGPLGEYVRSNRLLTSLSATGHDVDREELLEETLVRNGTLSTLRVANVCGGETSARFITSILAQCSALRKLYVTFPRTHFAEISEATMTRCAEALVKNESLEVLTLAYSLWHPNNWKAFFALLPRNRHLKKLQVRCMDLCIYETFPAVLEILAQTDSLTRVSFGDYRHGVGINLMHFRVFSSIELSGDEIVQVDALQRLPSLHHFTCLSLDLYQASERLFSALAKCIRKTNALRELRLTLTDPFNTANNRATSSCWRLLFESMSANTSIAYLNVFINGSFQYNDRLTRTIGLSRCITRVSFRVNPRDENATNLVSLLSKAIGDNYNLLSFDMFNAKVDVEAKRSLFTIRETTRRNSGLVERAAALSDTTRLDWYTANAFEKVSRCPALVRELAEQEGIDAAEVSSKIRSRLRSVDGLHDFMRLTNVVKTRVTCAAAVDGCRVQLKDINDDCWRIVRRYLSFDDVKRFGVANQDLSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJE4</accession>
    <name>A0A9D4PJE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_001125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036040"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7942771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="555" mass="61225" checksum="6EEE7CE57D214DA8" modified="2023-05-03" version="1">MEVSARTTVIVDNEMCVQVQGEETTPEEYHNEAGWTLAGERMSRLRQRAPASGMPDGSGGSQASPKSKFNKNVRASVINAARMPAIPLEESKIVTGTTTVATAILAAAKITSEESAADTLCPNTQQNIMVISTPNENNAARYATIQEIYIQGKLYEVSAYRSAPHNTVKGVIKGIPTDANAEELDRNVVNERNPLAVGAKRIGSTTSAIVVFEGPKVPNFVRYGVTLIPCHLYRKQIDVCHQCGRVGHRKDVCPTPTIKTCLACGLANPKEDHSCTPKCKLCGGEHSTGDRTCKATYKMTYVVRKRQWVRRQAELQLLPESDFPPLDKPSAVQKSRTPSKNRAPKSRDSSKRSLSKKMSPSHERVGWVDAAKGNSTSSAQKITEATKKDDMTKVREANETLRQENAALRTTINNLSREIAEIRKPLLCNNESPQRPTPSSSETEETSTKNQEAAVEEPAQNKRAIEAPRKQKENDRNDNLEAKFEARFTKLEELITANIAAVTAMKQTVDNYQTGNINRFAYIERTLQPITFYTNLPKGGRKARTDGRTEIMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK56</accession>
    <name>A0A9D4PK56_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK56"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053904"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="700" mass="78320" checksum="37261E2DC74895C6" modified="2023-05-03" version="1">MEGEAFPHGLLPHGLACTKRGTRVCQLVQHLTACNEALWHARLQLREDISDELGELSVVAVPRICEEFPCCDECANNQTSAPELLRQLLESHRCIVSLESNYDVVNSAPMAEILARSSSLRRLTVEGTAEDPPEVLDRAGGTDDRFHFLQKHATSTAAMEIPVRLLEKDGATLVSLDMMDLKISPSMAKKLMEALVNNDTLEELAVGDTVFYSGPDGGTVGPFVRYLTKSYSTLRKLTIRVSLPGVDIAELQTLARAISGVTTLEDLTWYGLVTRLLCTSFLEAVTQSRSLRSLKFLLAVCLHDLVLPCARENTSVPGWVTALRENSTLQNLDVDVSWFSSTDCCLLLEALAKGNSIQSVTLRYFSKYNDLVEVCRAVRDCGLDGKVHIEDYRVVLEDAWILPACRQVRSVDVSCWHSLPSMGVLRNFFRIAASCHHVTSMCVCFYFFDEATFASLAAYIRESLTIDQIDLLIEFSEHHHSFIADNDVAVQSMSNLIAALSSNTSITTMHLSTETYIGDRDCQVLADGATNNRKLRKLSVTGLSTFIHVFLDRLLSGLEHSYNLLLLELPFCDGTTERMREAQELVRRNCSLVDRATRFVMGDHSWYCASAFERVSEEPVLVTNVGRKVNATEEAENMIRGAQKSVRLMNIHDYMKLTGVVEGRVECVAREDGRPQLDQLHYDCWLIIRRYLMIEDVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PK59</accession>
    <name>A0A9D4PK59_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_009404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PK59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056363"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7943595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="719" mass="77511" checksum="6CC261E203857AF8" modified="2023-05-03" version="1">MMEYQVEGENISPEEVTQDQGWQTAGARRVSAKSRGADPNAAATLSASRGDKPSGAALKSKIIRASRMPVLPKGDTKIVIRPRGGLNISKIGAAAVADAILAAAGISPDELSQDTLCPNLQQNIMVASTPRRENADRYSRLKQIRISGNIHEICAYETAPHSTCKGVIRGILLQDDPATLDGKIVNQKNPLALAAKRIAQTETVIIAFDGHRVPNFVRYGTLLLKCSLYRKQVDVCHACGRLGHRADVCPTPSDVVCRGCGLPNPDEQHQCTPICKFCGGPHLTAGKECAHRFKTPYVVRRRRFERARQQEELAPPSILRSSDSQASSNPSPRGSRRSRPRNRSMSRRGSKSRSASRSRPSSPSPARSSSRGRSTSRTRSGLSNRPRSNTPSGGKGKSYLTWADRARGNQAQASNSQDSHDPRLTNELEELRRANDSLRKENAQFKQEISRLATEIAEIRKMALKPPAAPAAASSSAMDTAEAPPKAGAVKRRALDNSREDETLELLSELKKAISNIQSGLSQVQEMIAHPQLGLVALSERILRLEGTHQGFLPSTSTAPVPNLNSVIAPPTEAGRAILGMLGRNPAVVGPDAVKLPNDWVERIVRIISTPILSSSSTGAAPGESSDVPTTPCANLGLLKPSSSAGSHCFIAIRLMAAHHHGQLRGAPVAQVPLCKELLEAGAFGWHESLQYLCLELLIEVRRAGEDIGELAGNIRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKI1</accession>
    <name>A0A9D4PKI1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKI1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031698"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12215" checksum="7C15A3A57FA15A1B" modified="2023-05-03" version="1">MLHNICGPWRRERECEFTTQIVLALFSASTQRPRSTWSQTDAGTLISNRIHLVPQQSPSSGGLDFSSSSPRTQESESLPQTPPRPEPVRSSPTPRTLTLLPVASPPVAPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNJ2</accession>
    <name>A0A9D4PNJ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027790"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="32783" checksum="678D00AA1F80B909" modified="2023-05-03" version="1">MKDRERPFYKISNGHRIPGAFSEETLEGFLRYHPSDDDIFIVTFPKCGTHWAHMMLSKTLQVCRGLPPRPFILAEREGVDAILAAPRPRIVCTHLPFRLTPRNERTKYVYVARNPKDCCVSFFHHTRSHPSYGFADGTFEEYFEIFLEGLTDFGNYYDNLKSWYARKNDPNVLFITYESMKFDTRGSVIKLARFVDEQLAVALEEDDDKMKSVLDASSVESMRKEVQGPFIRKGVVGDWKNYFSREQSRRLEERFMQETEGTDIPDLWKDVDWKLHGPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPF6</accession>
    <name>A0A9D4PPF6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_003074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPF6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033860"/>
    <dbReference type="OMA" id="KKDMKPP"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7950891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24263" checksum="EF2E246EA5086481" modified="2023-05-03" version="1">MEPGKENPLVLSWHDTAWLPALDATNVMDYFSERSNPFYDRTCNNEIVKMQRLSPDQLNQMTGLEYVLLHTQDPILYVVRKQHRHSPTQVTPLADYYVLAGVVYQAPDLGSVLNSRLLGAAHSLQGALHEALGYSRYHPSRGYWWNFKDTPAATTAATTPAATSSSAASNTGASLFQRRRVDMLLAELAAKFPPEPPKPETADVKPAKAADKKQTRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS20</accession>
    <name>A0A9D4PS20_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_008343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS20"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030997"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7951376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="9429" checksum="5210E8090C4E7266" modified="2023-05-03" version="1">MFLIRCILCAAIGYLATFVAPWLINTLGFGRTGVRPKTVAAWFQARYKGVVPKNGIFALLQSWGMAGVPGALLACSFIVAGRLAWGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS42</accession>
    <name>A0A9D4PS42_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_017527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034545"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="134" mass="14376" checksum="11A94BC25BF94A86" modified="2023-05-03" version="1">MQLMEVHAPPGTVIGSILQDISLLPRFSVLDSAGKAVLSIEGPFCTSAVFCNDVVFDIFTRNGHVKIGTMSKNWSGVLREAFTDIDNFTVTFPVDLDVGLKAMLLAALFLIDFIFFESGAGGPNVPDLPGNVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT67</accession>
    <name>A0A9D4PT67_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT67"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="196" mass="22140" checksum="DEED6EF594B1ACE9" modified="2023-05-03" version="1">MCDRASYWQAWPHDPSLTGPERETPADVHAASQHASTYRISFQSPLRGRCVEFAQPHFDIRVCSDCGALPHKVVELPCRHILCLTCRGKHLIETIGPTGGDDTSGEQSIPKILCPEDWTLRSASELRPMVLRVGRVRRQVAYCLNSGLGCSFTAELRHVKRQYPTCRYEEFACPRCSVSYIPEADMLIHAFHCGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTJ9</accession>
    <name>A0A9D4PTJ9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_019682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTJ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040105"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="155" mass="16997" checksum="54B4BDAA3D2D9370" modified="2023-05-03" version="1">MQLLRGTSLDLLDASQVETLLSSLEQRDSLGGPRKVDVAALHQRLLQDSHALLAISSKERVQQEVKAVLQAALERNAEHERTYVSRQAFNAWQQLASVLVVCWASQLDAQLLLELAHELLSPSRTVSEQGPAAELLLLIVAALRQQSNTATDQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUJ1</accession>
    <name>A0A9D4PUJ1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUJ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043095"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="230" mass="26489" checksum="1AE82BA128FCC89F" modified="2023-05-03" version="1">MWRSEDEPKSSKKRARQKLARLTAREFATLLIDVLSEAKRRHLGTKQPVSEDQRLSDDEPLYDSVASDEDNHISRQLWQRMNDLQREHAAMRLDLEAMQATLAEFTRLQLEELPAEVLKEQQIDEQWRVVSSLRELDGSLKYARLSKFMLGVLTLPHSNAECERVFSKVKKVHTQFRASMSKKTLEQLLVARCAQSHSGKCHEQVFDKDFLRKAKAATASMLAHPSTSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVE2</accession>
    <name>A0A9D4PVE2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVE2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032216"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="343" mass="38768" checksum="2555DFB99E89C87E" modified="2023-05-03" version="1">MVWKAVTRSPGASLTYLRSLPEPSSLLKELDRKLENFCGTYMILPAYLHDTAQKLKDIVLWAVDAFQKLQTPPVPSYGAAFQRLSLAAESYVMGVVHQKVFAAVKQFCRQEDAVLVEKLRQLHLAGLSPDQLGVRESFCCPLPRSVVELASLDSKTTPLEKLWCLKTTLKMLSEEIYDSTAYSCARLKNPNEQLHLTSDDLIPILACLIVRCKLPYLESDLYYIQNFSWNLPEKDMLGYTLVTFQAAKEFLRLQDTSHLKPSHTPLRREITPTELMHVTARLQISEKKKKNDSSSSSGDEVAKNTATAPKSRPIDRQLEQAAKLIEASTSEFHQRETEDPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXA8</accession>
    <name>A0A9D4PXA8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_018131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXA8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027581"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7957361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="722" mass="78920" checksum="912BDDE9FAC3CE7D" modified="2023-05-03" version="1">MDICDDVSAKTTTPTILQGFVLSDARDILQENVYVILGHGKFQRQVLNCAVFSVIVLLLHAFAYRIIGRPVDHWCRQPDNLHDFTVQEWKNVAIPVLADGSYSKCSVYDPPVPDGSQEERRTVPCDQWDYDIKNKEDDVISRWDLVCQYSWLYSLSSSVYMLGPMLLVPLAGFVSDRFGRRPTMMASAITMLFSCLGAGSSRSFGVFLVARFMVSAAASATNLLVFVVLYEVTGNDRRALYCLLATCVGPTVTPTLLRAMSLLHPSWKALVVAWCYCIDESPVWLLAVGNVQQAELTILQGARYNGVDLGKARVTFKAFRKQLERLEMAASAGPAECGGTNSTESVGRVVKWRRQVASVLLSWFAVSLAYYGTAFLSLYLEEHWELTGLLLKALLFVTVHDSITRRGQRVTLSGLLLFLCASSVVKTAVVMSDVSVAIPLLSIMVEGSSAASWCVTCMYTTEVFPTTTRGTGLSVSYSVGRVGVILATWLTYVAFHGVPLWLNAVTTVVVFVSALAIQWLPEILVQKGRNKGESTPPKPAVEEQREEDTKATLAHERRSGKNEGGGGSPRRSSPSKSNTPRAEVVTQPSAKATLSRGSPPQERAASTPRRRSTPPKPAIEEQREANIKATLTQERGYLKNEGGGSSPKQSTPSKSQPSTPQAEVVTQPSPKASPSPSGGLPQRERAASTPIRRQRTPTNGKKSPKRRKARSSSPLPSRQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZK9</accession>
    <name>A0A9D4PZK9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Negative elongation factor C/D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_012042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZK9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030268"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61820" checksum="12556CA2A8557E2E" modified="2023-05-03" version="1">MEEFDEERTWEEGDADSPLGEDQEALVEGIQQECIEKFSSLDFIMEPGIFAQLKRYFQAGGNPEQVVDLLLENYQAVAQTANLLAEWLIMAGMKITEVQGLVEDHLKQMILKHFDPKKADSIFNDEGETPAWLTEMIEHPTWRSLIYKLAEEYPDCLMLNFTIKLISDAGFQAEITSISTASQQLEVFSRVLRAATDNFLEGGEERMSQNLSELTRMVCHGEHTYLYSQSVLHTLAQEPRGGSNVKRLAQEISRYAQRTGHDPTPITMALNGAAAYPRACQALSAMLSRDALNPADVTVLHKMYQTPDPPPVELLREPHFLDLLLDALFRPGSRLNPEHRPKYVYLLAYAGSVYETRRKGVRKSLNRDELRATQQAVEKVHMLCQERRGSSELVPELGALFQAMRYPVVALGVVLDLLVRLFESPPHEELDVLVQLERRKMLLDRMVHLLSRGCVVPVVSYVRACWERQDTDVSLIRYFVTEVLDVIAPPYTPEFVQLFLPLAESEEITGGLRGAAATAESSGASGGGGGSGEGDAVSEFVVHCKANYIVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q123</accession>
    <name>A0A9D4Q123_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_004345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q123"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057428"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7961166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="671" mass="76265" checksum="85DBFE0A30B63073" modified="2023-05-03" version="1">MKCTGPGFLSPAVSLLAGTLIGFVITSQILLWLNSENFCDSSPFKRTQATPKPRLLFVGVMTAEKYLSTRALAIQRTWGKALSGRLAFFSSGSSHWDGEEKLPLVALRGVDDSYPPQKKSFLMLKYMHDHYIDQYEWFMRCDDDVYVHVERLERFLRSVNSSKPQYIGQAGLGNKEEFGQLSLEPDENFCMGGPGVLFSRETLRRLVPHISTCLKHLYSTHEDVEVGRCVRRHVGIPCTWSYEMQTIFYHNFFGEVALKGRVRRRELRHRSLQLLREIRWAAQNYGGCVSPSQAASPWCKGIVNGSSALSEMPSLTKYFPGEIQDLLTWDFFAKSLYSDQVTNPRRRIESYYEISINNVISDLMELTNRYSKQRGRVIEFKDVLYGYLRVDPLHGADYVLDLLLTYRKYRGRKMTLPVRPAFERFLRTFRDVCLDADDACSLLVVQYRDTAAEADDLEGTVTAEKVLGADYDKSRVEFLPGGNGGEFSRAAALELGASRFKDDQLLFFIDVDMTFDAGVLRRVRAHTARRRSAYFPIVFSQYDPAYTGVSPEDPPRVAPEEGYWRQFGFGIAAIYKSDLAAVGGLDVSIRGWGKEDVDLFDRVVASNLTVVRAPDPGLVHVFHPVRCSRDLAAAQYDMCLGTKWTSVASERTLAAIIAQRHHELLTRNFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1I7</accession>
    <name>A0A9D4Q1I7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_018060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1I7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035595"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7962807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="885" mass="97043" checksum="02FCDD3806829DBD" modified="2023-05-03" version="1">MLYLANDVLQNGKRKGVQQFIDSFRDVLPEQTPLFRDERIAKQVERVFSIWAERSVFSSDFTKSLKEILQSGKPKNPEVERIILEFKPEKAIEKIKKIKKIEIETSTKLSNLTSRNMDVSSSEVLRKFKDRSHGQQFQKDFDEATRCLEEYIKALEKEVSERTELISMLEDAKVYYDSQNGEARIVASAYKNFGNRVKGLKKKLEAKTKTLPSPVPSPTPDAPSPTNSDDGLQLPAIQETAEYSAPDVEAPLMTDNGAVIDSPCSAPSPGSAPSPEGSPVGLSPVVPGTGDSGTTSNATGNATALSSFMSQSPTVLSSWLDAFNQEFQENRAAPTAVNTSTLTAAIPAQSTLESRLSNLMQSMGHIPGGLFSSTSSASNTPKRADSPPYSAAVFRPSAAVSEVHSGNTPLKDENSGQGTPVLDENTARKVASLMDSDMRVHAVKPVTPQDSPDARLSTPFGSRIPSLASPKAWMPMSPKAGSSNAAASQGAPALAPPPIPPALQAYLEPIKTVTGAANRSVAAAPKGRSETPPSPSADYLIPVAENFDVTDMELDEDGSGDDEHSEGLHRKKTSNLITLVQPQVSPVAETSSPDSTCSERNEDARPQLDTPTQPAVVTSALKLTPSLASQDDTRHMRNPSPDLEKEDVDFPAQKTPSEPRRCESTDFAVKESSKFNLRDSVDFDARKSTEFRLLESSDYTTRERSEFRVRESSSSSEFHMRESPSSEYRMSEPPSSEFRIRDSSSEFQIRDSPSSSEFQVHDSFSSDFHATPAKIETVQMRSSLDRSPPLGPMEDRGTWERGDYYSPRAAHHQPQQQQAMSNGGNRMRGRSSGYYGYEMRGRPVDRYHEGYGAYESEWHGGRPPSPRYRHYGGQARGAPYFQPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1M5</accession>
    <name>A0A9D4Q1M5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_018187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1M5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026634"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7962839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="471" mass="48963" checksum="9C881B425F16CF72" modified="2023-05-03" version="1">MTSEWNGVKIASYPASVVSAAFPFAGFDYRFPYGALPPPATPRDSGAPHGIPLSLLDRGHIGDLGARSSIPPTSGGGGPSPLRPAPLTSAPSSSSSSSSSADSHVKRPMNAFMVWSRAQRRKIALENPKMHNSEISKRLGTEWKHLSESDKRPFIEEAKRLRALHMKEHPDYKYKPRRKPKSMLKKDAHHHRFPFALPYIPGPGDYLGLAAGLPRSLFPPHPRIAIPFPQHPAAVASLQQQQPSPSPSPSQARSASPRSCHAEENNNRPSSCDDVVIGSGGRKLSSPSSLLATASSSSPPASSASTTPTSDPAASPAFKAFLPPSYASPYCPTSSSAAAAHAAAASLYSAAGLSYLMPCGCGSPYAGGAADPNCRQHLGPTPPVSTSSSLFALNPFLKSVESGLPPGYAGHAAMAAAAAAAAAAGSLLDDPQSMSTVPSAAAHLFGLYSSLARPKPHDARLEVGASSLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q294</accession>
    <name>A0A9D4Q294_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_019632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q294"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056250"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038670085" description="Cuticle protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="42421" checksum="EF9ED15E7DC03DFF" modified="2023-05-03" version="1">MLALILLSICGTTTVQAGYQGHSGLLLPRVHGTIAPRIFPGRPIGLPRGPTRADTLPPPNLAAGTFHGIPPVLERYPLPSYPLGPPLTKTHVDGTPSVHLTRPSVVRVPSVPAVPAHSAFVPPPTVLVKQGPSSPTVGGAIVGGRPAVRTFTPRIPAVTKVLTPVVVPGSFPEPLYPPHPYEFGYDSVDEFGNTQYRHETSDAHNNKRGSYGYTDANGIYRRVDYVADANGFRAHIRTNEPGTASSAPAGAVYDSKPVTIRATVIKSQRGGLLLPHDARLNAGKEFIVSPVKPHPAVVVPAVSFQDGSKGGHPTPLAPHPIATHLHGPPRALLNNDSPVVVGSHPTLVGAVGSDGHHDAAEVVATKVLTDPAAPHGVHATLGVVALKRHHHVHVSGQDYKAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2W6</accession>
    <name>A0A9D4Q2W6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2W6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057571"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="355" mass="38824" checksum="1160631137433CDE" modified="2023-05-03" version="1">MEERQTGKELSEACKPLIDGAGQEQLASQEVLQSSQVAELPKRKQWLARKRQSMDQPLVASELKQEQPQDSEKVHGGPTSKKLRLSKQQLRELFSSSSEDEEVAEENTYTAFLASTEHAALCKAVSGKLLSAKAARTAMSKLSWLAMQPEVRPGVVASFVRNVKRDALIHAALLYLARTKANPVAAYCRGEQSPPLITKLETLLLDALALKTNGWAALLSSLRARLWSPQQPTQMLAQASYVRLVCTLCSHLKEHKLALVTAWDLVCSSHAPFLVASAVGAWPGLLSALPPGPLQKAIGYILLRSPAHSLNSTLQSQAYRTLCELGPLQEYEGDERALVEELLGPLLSPHQPCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3V3</accession>
    <name>A0A9D4Q3V3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-activating enzyme E1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_002155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3V3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036934"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="4">
        <location>
            <begin position="629"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7967749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="746" mass="82995" checksum="9C692AAD40B7719B" modified="2023-05-03" version="1">MNEINSCPPMKVKVLGPTEFSVGDTTQFSDYTSGGFATQVEMPNDIKFKPFKESMMNPDFVVSDFAKVNRPAQLHLGFQALHAFERFYSRLPRPRNKADAKTVVKLAKKLNTTMATPVEAVDDELITKLSCVSAGSLCPMQAVIGSIAAQEVLKACSGKFNPIQQWFYFDAFECLPQDADVEESDANAMEYSRYAGQARVFGVNVQELLMTQRYFVVSYDVPSSSQKQARLSVSKFAMMGIGVDDGCIYVSDNAFVQRSDLNTQFLLRSPDVGALKSVMAGQTIVELNQDINIAVCVDEVCPETNICTDDFFESLDGVAIAVDNAETRHFMDRCCVHYGKALIDSGIMATKGSVQVVVPHIIKNYSASQDPPDESVPADTIKYFPSNIEHILLWAREEFKVLFEQSASNADQYIKLRFQEQYNDQIRQLLCAHPENQITTSGAPFWSGHKRCPHQIQFDPKNTLHMDYIVAAANLRAAMYGLAHNTDREEIADMLESVEVPALGPQNEGVQEAAIDANPPQTDVPQPDDDNVLAKLLEELRHAKRLVDVPLSKMEFNTEDDKNFHVDFIVAAANLRASSYNIEPAGRLKSKLIAGKIMPAIVTTTSLVAGLASLKLYKVAQRHDEPKLYKNGFVNLALPFFSFAEPVAPIKKKNNHKVNIVELSEGSRTLYATSQPSSASRLELSMSELVEAVSQQEIDPDKRFLVFDLKCRDVNGRDVELPRVRYELSRNEDGGDAKMADGREQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q4T5</accession>
    <name>A0A9D4Q4T5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q4T5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047461"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7967631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="412" mass="45922" checksum="A4B8E996F36412A0" modified="2023-05-03" version="1">MRPPERSARRSYDQTHHLTKCDNNNSTRRKPERMAVVHVARTSPSWTNPVAAPAAHNEASPAEACLGLSCGRAPLLEQGPARAPPSTSAILMQHENNQVNENTSDSSSAETTAFKALEKRVLNQHKALQSQCEQLQSQAHGDSSAPTPVRAAVAVVESRLEALVQTKSPVTAQEHKIEGTTVEHTIVEVIPERKSQQSLYVTKVYSPPRDQLTDFNHFIRELRKRTRGHRLLVVRDFNAPHRAWGCVITTKKGARVHDVAQQHGLRLWNDPLQPTRAGNSVSRDTNPDLTFTRDVKKAGWTSTIPPPPKEYEGIPNADLDRPLTPAELQAAISKLTRNTSPGKDRIVNKHLRQLPNQALTALLRYYNECWEKGELPATSPRFEYSACTCTATDQGPPRFLDFNTRFSNSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q616</accession>
    <name>A0A9D4Q616_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q616"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043365"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039349980" description="Monocarboxylate transporter" evidence="2">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14557" checksum="45933C5B41A00CB1" modified="2023-05-03" version="1">MAVGFLLASLSLLALNHGDSILLGGASVLFGLTGGSIMILFSVLIVEYFGLKKLPMAIGIHCLVNGLSALPRPLIIGYYRDRGSSYAGMYVMLAAVSLTTSLLWAIECFMKWRAEKVTTRVNEKAPSVSEKAASET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6C4</accession>
    <name>A0A9D4Q6C4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6C4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052583"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10422" checksum="6E831AEDFC52FBB2" modified="2023-05-03" version="1">MEVRDAFEKYDKVFVYSVSNMRNSKLKDVRQEWKDSRFYFGKNKVMSVALGRFIDEDHRENLHKVSERLRGQCGLFFTNAPKEKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6K4</accession>
    <name>A0A9D4Q6K4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_010507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6K4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050151"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7968651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="128" mass="14996" checksum="A23A14B9B65BC928" modified="2023-05-03" version="1">MAKIKGEGKREKRGKSTLNEVVTREYTIHLHKRLHGIGFKKRAPRAIKEIRKFAEKQMGTSDVRVDTRLNKFIWSKGIRSVPFRVRVRLARRRNEDEDSPNQLYTLVTYVPVESFKKLQTVNVESSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7J8</accession>
    <name>A0A9D4Q7J8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7J8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="12926" checksum="FAAA93F9B7BBC995" modified="2023-05-03" version="1">MAGYAVAPTIDEHFFPDVVKVEEGSRSRLMYPVSNGDPQLRFRWLKNGLRISYHAQRVIETPDDSSIIKIGRVRLADHSQFTCLVSNDAASVNRSVERVVHGENAIAWYRTGSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q838</accession>
    <name>A0A9D4Q838_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xyloside xylosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q838"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041992"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140560">
        <property type="term" value="F:xylosyl alpha-1,3-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46131" checksum="ADF00F92B3F92FAF" modified="2023-05-03" version="1">MHSIAARLIVYSLFVFGVFVIIWCNLSGAPPKYNRHQVLSNLSPLSSIAPLIVTVRQTTTTTTITDAAASAACEAARTPAALHRPVDVVFVAKWAYRNMKVTRIMSHCLKSMLAHTKSSVRFHVLADPQSYLRLSRTLGSIQEESKRKFQFFLYNITAVEAGNRDVIELMRLLFFTKDVGRYNDDMFFITEIFHRVFDVPRILFIDLDLEFEEDVAKLYAHFDCFESETLIGIGHDLQPQYRVDFQSYIDAHPGTDVGLPRPGKQGFNTGVMLMDLAAMRASRLYNELLTYEKLAPICAKYGFKGSLGHQDFFTLVGMEYPELFFVLDCTWNRQLDTGWSHTVNKTTFDAYHRCPGKVRIYHANGGARLPEPGSVDASGTKMRKRKKIPLHLYPSFPSFTTPEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8A7</accession>
    <name>A0A9D4Q8A7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8A7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030808"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7969996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="19996" checksum="352F73E563CE498F" modified="2023-05-03" version="1">MADGKSSAQTDGTKRKSLDISTKRAILNELAQGAKNCELVKKYGMSMSTISTILKNKDKIISADANSTDRKRLRRATYVDAGFADVGADADPEASEEDHSGGDLWQRVVDSDMGGRDICWDDFVMADDDADTAEPCTDEDIVIEVCGKSDSEESDDDDDETLEPAPTSVPVAIGYIVPHTYIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8F2</accession>
    <name>A0A9D4Q8F2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8F2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042488"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="109" mass="12060" checksum="66EAC2707430DBB6" modified="2023-05-03" version="1">MDFADIIKPEFSLAVRWGSPNSPFAQTCEFGAFLDESLRDRSVCGLLRVDIQAHLFSDDKQLTFQRAVDRATALEAALVNATATHSKPGSVFEVHQLPTKESTKCSRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8V5</accession>
    <name>A0A9D4Q8V5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8V5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040941"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32847" checksum="1C2DCCDF4DBDFA2E" modified="2023-05-03" version="1">MCLRCALRLGADAAEVQDLWARYLRAKNSMSTLVQDRMRTINSKILKEIKEAGRDAGKKFWRHIQGQKSTAQPCTDSLQDPEMGLEYREHMAGKLRSQAGHSIGLDKRPQSPDLAQCDGITERELDRALKRLSAGQRHKVRERVRAAELERWRTSAQTKSALSVYRANKQAIEPERFFDNSRGSSLLSEARGGVLRTRSLQAKYTPSTSTTCHRCSAAEETIKHVVLECTGLQPGLPREQTNPSCPNALATALGFHEQGAPPNCKEVELTKRRLEHWWRTRNPPAPPKSADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8W1</accession>
    <name>A0A9D4Q8W1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8W1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034942"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32060" checksum="E6E1BD4D4E6BEEF0" modified="2023-05-03" version="1">MPNIPDVRHYDDLDDQRLEWLEVTFPEYMENLKKQATHARGFLTTETYEALLLTTDINKKKGTGCGKITWPYYWEINRFLQALPMNDASLLQETACSDSSAVEQIIRDMEMGSTCEQEDDALGDDKISVQVTDPTATQETEASASPTEGTSSAEIVAGLRVDSRYTVLGARMLGRSSSAVITFDGPHVPYYITYQSGDYRCKPYRKSVQYCRKCGAIGHRQGHCHGLGHCPRPREDFCYKCGQGAVTEDHDCLPKCKICGKAHETAGKECKKKLRRNPPPYQVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8W8</accession>
    <name>A0A9D4Q8W8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_023964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8W8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038013"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7970075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="400" mass="44259" checksum="E3629DB63177DF51" modified="2023-05-03" version="1">MNRFVWASENPQSGEVILRQQPGVALYDGERKTPFVGGELVLTSHQVYWTGPEKQRISLHLSLVVLIEEQSGSWSKRYGCCGNPVFDVTNVLAHHSAKIVVHVSPPTDDKHVGVVQSSPFDYVRLSFRSGGSSEFFQEMQAALQRKDWLKMPTVDSRGKKIRTGIVGIERQIQAKHDEADKNISAAFEDLSKLMEMASAKDMVALSKSITQKLKEKGSSLTDDETVMFKSHLLSLGISDPVTKSAYGSGMTYYQELAKQLAEVLEGPVQESGGILSLTDVYCRINRARGLELLSPEDLLNACKVMESLQLPLRLHVFGSGVTVLKLATQNDEATSTETRQLASIDEHGSLSAEQLSPLVHIPVILAKERLICAEQKGLVCRDDSVEGLRFYPNLFLEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA33</accession>
    <name>A0A9D4QA33_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_023962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7970073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035810"/>
    <dbReference type="OMA" id="HDANNSY"/>
    <dbReference type="OrthoDB" id="9518664at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038757071" description="Serpin domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="9">
        <location>
            <begin position="31"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7970073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="394" mass="43078" checksum="9B2A671344BBF98B" modified="2023-05-03" version="1">MTLGILVLLYWTCVTCMCSADDVAGSTNLALGLFQQLSADTSDNVLFSPFGVSVLLEILSAGTKGDTGKEIESAFGSDTAAVKRDIESAFKEMCSSAPSSGRKSPMSLGNLLAVKKGLKSKLLPQFLKFLKDGGPFSTLVDELDDNLANRSNNWVSNQTKGQITKILDGDSTEDDAKMLLLNAIHFKGDWKEKFEKQLAYNGTFKNYGGSDTPTMFMFKRRHFEYALDATLKTHVISLPYRDVKARFVLLVPLKRAGAQTLASLLTASEWNRILGTLRNTSVALSMPKFDLSKKYNLMKPLQYLGIKKIFTDKADLSGMMGTGDLFVSAIEQVSKLRLDEEGSEADSATLLRISGKAAEEGESVVADHPFIFAVTAGRRDDILFMGQVNKLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAF0</accession>
    <name>A0A9D4QAF0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_011885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAF0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048314"/>
    <dbReference type="OMA" id="ANDCAIH"/>
    <dbReference type="OrthoDB" id="63185at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7972401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16722" checksum="0C27EBBB6DAED299" modified="2023-05-03" version="1">MARRRAPRLLPSDNGTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD02</accession>
    <name>A0A9D4QD02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_003250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD02"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053691"/>
    <dbReference type="OMA" id="RIEQPFK"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000006">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7975570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="333" mass="37433" checksum="711914FE088E3461" modified="2023-05-03" version="1">MSAAKSARVVKAASALRLPPMPSTSDLLRMYGIRAMRKLSQNFLLDPKLAKRLVRACGSVRDKHVIEVGPGPGCLTRPLLELGARRVVAIEKDSRFAPTLEILSEASEGRLHVVMGDIFHQHLPELIPEELGVSWESDELPEVCLVGNLPFSVASPLLVSWLRQISRREGPFQRGRVPLSLTFQLEVAQRIGAPILDPQRCRLSVLCQNYCTTQHRLTLNGSSFVPPAEVDVGLVRLVPLKEPIIRHPFDLIEKVINCLFNGRQKVLTNGAKNLFPRVRQEELVPRLIKLSDVDPTTRILQLTVEEIGRLCDVYEEICTEEPKIREYHFRLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD75</accession>
    <name>A0A9D4QD75_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_008685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035543"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7976126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42312" checksum="5F20A1E09F0DA397" modified="2023-05-03" version="1">MASWEYTLTGFSAFLEQRRVSFMQPMPAGCVCSRCGRVPAVMVYLPCGHVTCEYCFRVVVLGAACPLDGLTFTADQLVYHRVPLSDLENRRVFCTVGGRRCPNFAGTLGELTEHMLHCRSVDVNCDKCRRPVASELLVDHYRNCGQGNRAREVPVDRAAEELGGVRADLLPQRARDDGDVDVDNAQGAYILGEMLASVEGALSSMQAMADSVHRGSPSPRTKTSIVGPSRTPSKPGALIVTCKLFDVHTARDSVAPGVEHNLSSELYTLAGYTFKLQCNFASSEVEENVEEVNVRFGLFLCAGVWDDLLEWPFPKKVSLTIAHPMDEAKDVVLALPMEGNQVLKKPRSGRNSNMGYMTEPKPWSDIELHGYIVRGALYVNVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDI6</accession>
    <name>A0A9D4QDI6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ninjurin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_005631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDI6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028563"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF17">
        <property type="entry name" value="NINJURIN C, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7975825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17488" checksum="333EFE2A9C6C09F2" modified="2023-05-03" version="1">MYCARKWQQNYSDDDKREEGSPEAPYPPAEPGFVTPSVPGGGPGGKRVRCMDMNLYATKKSIAQGMMDIALLTANASQLKHLLHEGPEANRFYGLTVACVALSIGLQVMVGILLIFNGRYNINKTHQQRRAELFNNVIIIGVFLITVINIFVSAFSGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QHD5</accession>
    <name>A0A9D4QHD5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QHD5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7982887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="443" mass="48632" checksum="1B05149E54C5BE7A" modified="2023-05-03" version="1">MEVSPSIRQPTSTKRPNDGTSHGSAAETAPGVASGASLCTAPKRPRQMHTNPSSEVNTPEPNSRSSYKVVIKRRSRYDMSTLPNRVVQAALDTCLKTSRFQGFAPHKATNTISVWVPAMSFVEMLKDLQQIQVTEDYALPVQAYLASGTDLRRYVINGVDPNEEPEALLRELSCSTHKVVAARYMGSGRTCLITLQGPRFAPERILYYGCVLRPRPFKPSVVYCYSCFKQGHMKSSCPCSSEDATMEREASAPFRCGLCRTNDHDITSASCPTKQKATMKARQRRPGRPVRTPEYPSMDPVPIHNRYEILASLDADDTHVAPATTTHHSAAPSYSAVVGSSSSRPRRAPPALEDVQLPLANDESEIDSRLASLENEIQRLKQHRALLQRRRDGTHSLHTPLASTYCPYGTNSCPSTQVETSIAPRTATLRCAATPASHIGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QKB7</accession>
    <name>A0A9D4QKB7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QKB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043888"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056334"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056350"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="341" mass="36511" checksum="767F74A7D03D71F6" modified="2023-05-03" version="1">MNREFAEGREGSAPSPAVFGSVQDGRAVCGGAMRARIPVKTRTGSEALAALFEGICRPRGHTAEYPLWCHVRAESQATVCLLAEEWNVDADCKEVPASPIAIESRREPNHSGGPQQKRNVNAAHSAAAVEISGNEADDFRGGEEETGECRTGEREVAEVGMAAHAMCADAVRRDDVVDQERAANGANSEVEKKKKRKKKRDHDGRRSDVEATENAGDEKCAEVDEVSVAYAYVDCHDGNEEAEESRDGEVAAVEEGKDEDNAGSDDGTGNWEGVANGDAVDKEDELAQHGGVSGETAPNTKREPKKNVEKDGGQEEEGQEKNEVGSKKDESEDDEEAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNG6</accession>
    <name>A0A9D4SNG6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_014270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNG6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045333"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="247" mass="27019" checksum="48C3B75767A885BF" modified="2023-05-03" version="1">MALFPLLSNRGSRCPSDLARRFFEEDDFGGSFLDGELFDPPFYHRRYHLQPHHQQRSSSTGCPARQQGTSVACTPDKFAIRVDTRHFTPEEITVKTQDNSVIIHGKHEEKSDDRGCYVKREFTRRYVLPEDVEPETVKCHLQPNGLLALEAPRKNAPKEQPKAIPIEIKHEGGSGDALKKKSNRPPAKVLIAGGVVVVLFIVLLLLLLLGGGSAESKGHKGTDGGGGGGDGGDINFGGGKWRTNNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPC6</accession>
    <name>A0A9D4SPC6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPC6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044163"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18283" checksum="5EAA58F1AA70FE7F" modified="2023-05-03" version="1">MEAAKKPMDPADDDVAGKADNRDIVTIWSEAAILFEHSGERNDFAPGAAARCMPGLREQRKNREFCDIAFRALDGSEIWAHRFVMAARYSGCHALFAIAKEGMNPEDKLLPPMRLVVEDLGSDFIQLLVDIAYHIPLHDLVGPHNVADVLDLSEKLKCLAWEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQ78</accession>
    <name>A0A9D4SQ78_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HPB52_011385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Rsan-2018</strain>
            <tissue evidence="14">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQ78"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050781"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7939355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53866" checksum="3F03CACB8F919205" modified="2023-05-03" version="1">MEDIVLEYAVFGALMALNFGLGLYFSLRRKARLAKTAAEVFLGSRALRALPLAASAVATIVSSAGLVGIAGHFYAYGFHLIWHAFAAVVLAPVAAYIFLPVMYGLRITSVFELSRLSSTAAGRRLLDRAGLLPPGECVGTGPYGELEEQALLSDEAARKIIVYPLPKNTDPERDEGRRAARAVALARQHQQDEGAVYVDAARYPRRRNAFVATVVRATAGELLTASTVRARTAGQAEEVAIALAMGLPGTRTVLSDSKSAIKNFARGTIWQGTERLMRSIEATWAARGAAAGPTIALKWFPAHMGRQLAPDIENRNEEADAAARDLITCRTAAVRPSETSGEDQKKDFEPLTDYGGILAAYREVRRAFPHPHRELSRAEAVKFRQLQTECVLTLALARHVCPDMFVDAKCSVCEHELATLRHIMWGGCNSAMHSGNGQCQDATYPEEVRAWIRSEDLKTQRRAIQRLEEALAKQRRKGADDPSNGRGGTRVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRI5</accession>
    <name>A0A9D4SRI5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRI5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="24135" checksum="7773A8F4D392C2B4" modified="2023-05-03" version="1">MLPSLCPPVKPFHPAYPRAWFMQLDAILALNGITAQPMMHAVLLQALPVELHHLAAATTSSPQPYDDLCAAVLARYGETYRPLPGTQYGKYYRYNADAGAEYSFDPKENRILVFDSEKGIKQKVCAALIEHAGLRFSMAAYDIDFDQEDAPCRSLFIGRGSYRRVKALRFMSSYTPYIYDDLGYSHEQCMKQVYAEVQNPCCPDSTHKAEPEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4ST17</accession>
    <name>A0A9D4ST17_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4ST17"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036359"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7944381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="536" mass="56276" checksum="14AA5672D3A76090" modified="2023-05-03" version="1">MSCDFARSVDVLFYGVSSSLAGTSAEEPQQSSTVDDVIVVESDDEVIEEEPPKTEQLEGAESGMEDDYEDEEMNVTCGASRGPGEVDVPEEDMAEPESLDDAEREMDDGNEIEIVDLGDDAGEDNEMEEPLAEEEDVQPCSAVPVEAEEELQPAVNTSSATEVPPSLLVAPVLLQQQQHRPSLLPRVRNERLPSPHVPHGGFVFGTASEGSSAPEPSGLSQLASQEESRDASLFQGDASVVEEPPEEAPEEAAASQEEEEEVGPLVVRSPPTVLVTEAPESTEGPSSAVAVPPIVEEPTEPEESPAKAEQAVVSPPPTIVVSPVPILEVTPEEREELLSLEGETTDTGADVGSEAQASEEPAPSGGDGSTTTPSGGSSQQQQQSAQQQSTQQAPPQRRRIVWEEPEPASSSAAATVTPPQGAAQAAAAQQLSPSLAHFSSPPPVHAVAVPASAGGAAPAITSPQQPQQQKSPNVVRGLRGRRVRLRGLVPQRRGSGPQARGAGPQGRGHQIRRAAGLMWSPNWRGGGPRSRGPHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUR9</accession>
    <name>A0A9D4SUR9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUR9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="379" mass="43402" checksum="AFD80B435E9419E8" modified="2023-05-03" version="1">MEITEIACHLVQFTVRQMKGSTTERERIESQVRKAPMAPVVSPFSSISHTYPGDCDIATPLLRFEGLRDVQMPKEFLGKVDERKRLKEELDTHTQHPENLKELIYGISEFYDRIGEDVFEVNLVAGSTYPCFNALVDAGDDLMERARHRLQYRPPPPKTKSRATWHIRRTACLTQWQSPSTPQLSSSRGMRQSPRPVAQMGARADLRDEYSWRRSLHSPDLGLRLLALRRTRAIAEGLQLPVPAWVEPCLQYTSVQAAAFDDTSLNSDRSPLLRQNRQGTPPTRERWLSADGLSASLDSNRKTLREMARSIIKEELHPQATSTVKFVTRFYKRNPRRNLFDSNNNCRNVLYKRTPTLYANPPCTMLRLQPPVAAHPDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV42</accession>
    <name>A0A9D4SV42_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV42"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053854"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="257" mass="29867" checksum="3A3D46B5AD902222" modified="2023-05-03" version="1">MASVLAYTKELYDYIWSFRDTRIDAWNSNITRGSFVIPLIISYVYVAKIGGPRWMKDRKPYDVKRGILAYNAFTVLANAYFLYRMLPLTLFGGGYSFLCQGIDTDRERDMAVISLNWWYFLVRVADFTDTMFFVARKKYTHITHLHVSHHALVVLSGWIWLNFGSDGQGRARHMYQRKYLWWKKYLTTIQIVQLVVVCAHSSLPIFFECGYPKGLCYLEMAQLVLGIVMFTNFYLKTYMGGGRSGPPPAEKSKEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW30</accession>
    <name>A0A9D4SW30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW30"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="593" mass="64922" checksum="A36759B00A0E6F3D" modified="2023-05-03" version="1">MLSDTEETLTATDKAATIGSSTDHNTGSIPTAERTNDPQLGEGMDEDSAAFNTVTDATEDDAYNGACWKVVRNKRRARNAAALEAASLLKTDSEKPLTKPRPSGTTRLPPFPFRDEKVVLRPLGGLRLDKWPKPTLATALWAAAGVNPSDRKNLILRTRPEQNLAVISTPSSHVADALLQVQELSLGQRTYPVSSYLAAPDDSCKGIVPGLEPGTISHTLVEEMQATGIQILQARMMGQTNIALVTFEGLRVPRFVRFLGAELRCYPHRPRHPVCKTCLKLGHRADHYPTPDLIICEQCGIDNPMPSHPCSPRCKSCGGDHATTDPKCPRRQRQSFNRSWVKKAIDDERRQMTASTDAAPSSATTHAPETSKKSGRSGSNTRFRSRSKTRTKSKSRSRSQSTSARIQEKRPTTPASQASPSPYKKALLSKPATSTATPNHQQPRASDNSNAMAAPREVSFEQGPTQLTPPHPPHHNTFRPSPPPNTSTDPFPEIARLRRDMEARHAQMHAQLDAAIESTNARIQAAIDNVRQESAVSEERTHSLFAELVSRFDSVAPLPNPQAMRPQPPLTGARRTHPYSRPTTSSHDDDGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SW81</accession>
    <name>A0A9D4SW81_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_011048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SW81"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034600"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="235"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7951652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="431" mass="48720" checksum="2558167325D8AEAF" modified="2023-05-03" version="1">MRITARLLKDIGKMLDKYSRFHPSPLSIKQFIDFGENACEKTSFLFLRKELPVRLANIMKEIHLLPENLLSMPSVELVRSWYERSFQEILEFENAGSDDQKAMTKFCEALIKIRNRHSNVVQTMAQGVIELKESHEPDPKTEHSIQYFLDRFYMNRISIRMLINQHTSLFGNENNTHPRHIGSIDRNCNVASIVEDAYENAKFLCDQYYLTSPGLIVEQCDVIAPNAAICIDYVPSHLYHMLFELFKNSMRAVVEYHGTETESNDLPPLTVLIARGREDLTIKLCDKGGGIPRSCTELLFQYMYSTAPQPSASGLNSAPLAGYGYGLPLSRLYARYFRGDLILTSCEGYGTDALIYLKALSNEANEMLPVFNKTSSKHYSSAVGASDWIAPPPPAPAAPSPQGLRHISNLPFNVAKQSVLARKFSQQHKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWP4</accession>
    <name>A0A9D4SWP4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_020925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWP4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034409"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7952255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="21494" checksum="6CCF6D611E49AB68" modified="2023-05-03" version="1">MLHRAKPQLLMRTNYRSAEPLKKKKRLDPAILRMREERKKRRIEKGIRQLKKHAKKYKPIEEQEVAPKLQKELGLRHRALPVLDHETCQLREAMQRAWSIYCMRKHQNEAAMLERIVSTQEKALEMLKEASEDLYSAAIQLAMSEMNAQLFPEQIKELRDWNSLGSEPYPQHEGDGISEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWV7</accession>
    <name>A0A9D4SWV7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038417"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16999" checksum="8AC6F6FE935D9DD7" modified="2023-05-03" version="1">MVVPQQKLLCAWHVDRNWQKKIHEYEEKQLRPDVYHNVRLLLEFLDTEEGKLRDFLKYFKDNYAVRPQEWAYCFRTRVGINTNMHLESMHRTLKHNMLEGKKNKRVDKLISALMDLTYHFFDEEGNPDDQRSKGQEVECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SX58</accession>
    <name>A0A9D4SX58_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SX58"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11304" checksum="0501A6D8ABF7EBF0" modified="2023-05-03" version="1">MPGGFPLPGMAAGAVGRAGPSRGLRVAMFGVMTFMLIAVISVIVVTLFAVVFLSRKSQDVVMRRLHPEQSPQAMLPFQLPPKHQASSYTALFYFNTARIFRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXH5</accession>
    <name>A0A9D4SXH5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HPB52_003886</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Rsan-2018</strain>
            <tissue evidence="17">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXH5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044680"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="13">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="16">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="15">
        <location>
            <begin position="451"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7955793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="610" mass="67197" checksum="6947E5126AF5EDD8" modified="2023-05-03" version="1">MENRLTAGAVERILNNQQVDKPVLQVLNFKPISSNTADRYRLLLSDGVQCHTYAMLGTQLNGMINNNEIDKFAVVQLDKYMCNVVSPDKKVLIVLDLTVVAKGSTVGCRLGSPVIPTSSSSGAAQPTDSSVLSADGGASKPPFQPNGGNAPPSAAPSFGNRAYPASTSDVVVVPIASLTPYQNRWTIRARITNKSNIRTWSNSKGEGKLFSMDLLDESGEMRATAFNAECDRFYDVIEVNKVYYISRAVIKNVKKGYSFSSIKNDFEMSLIPETTITPCDDVTPNIPTLQFNFVPIARLQEVSKDSVIDVIGVCKSAGDVQTVTRRTTNQELKKRDVNLVDRSGTEVSLTLWGDQAEKFDGSDNPVVAVKGARVSDFSGVSLSLISSSMLQVNPDIPESHALMGWYSREGTLLQTRSLSTQRGGPMGGNSNWKSIAQAKAEGLGQGDKPDYYSVKACVSIIRKENCLYKACPSENCNKKVVDLQTGYYRCEKCAQETMEFKWRLLVSANLTDFSDGQWVTCFGKEAETLIGASAEDLGEMYSNSSKEDSRYEDILNDVPFKPFIFRLRTKMEVYNDESRLKTSVMSVSPVDYVEYTKKLLKDIAELQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZ30</accession>
    <name>A0A9D4SZ30_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZ30"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044184"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038630068" evidence="1">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="235" mass="25978" checksum="69BEDCD0EC43F73B" modified="2023-05-03" version="1">MKTCVCSRFFGLVLLAGVILATTVAAEISAYTDYYLEDHCSSSRSADRYRARTEAQSISFRLKSPMQEKLDERGCRAGLSFSTLNETYGFLVTPVSIDIPRGPTNSCVNFIWFDGLAEDELNGKRLCGDSFPKSSAIRTKGDRFTIWWSSEPSRDADRQASFNRSTHDLAAHSAVPAPRNARVGVTRGAAQGRLFWKLRGITPHTSRSSTFVISRIYTKRLALGQGSLEGFEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZC0</accession>
    <name>A0A9D4SZC0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZC0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035444"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="582" mass="63035" checksum="C543CB840B9B95E7" modified="2023-05-03" version="1">MFRNTEQWELTCGEGGVGDHPPARHNHSCVVHQGAMWIYGGLTDLHERADFWTYHFDTGRWSRIRQPKGAPTELHGHAAVQAQGFMYLFGGERAGAANNDLWRFHFASETWEKVAVEGTVPTPRCRHVALVNPGLATWADRVSAAKEDEESGTALHQHRPRHGRAASLRFKVHPVSRLCSKSTGSQDDDEDDDVGCAYGGCGAQVNLRSLKEKLSSSRLVRSISSGNYSVSSAVRRDETEKLLEGADPASGVPTPQAIQKSASTDAVLEASDSSGESTPQHQRKRQLSVRVRPLSEILPRNRDCSVPVPPGMLSPPPQGGRSRRITSSQSLNTFNVSSSAAAPARSGASCCCTPTATTGGGSDQQHTPCENATDPRADLLIDLDQSNVRYRVGGPRRSTSSYTWFSDASSSGVPASSPLQLSHSASHCSGYYSFAEDDPELQRDIMNFLTGHGPRSRPSSLNSATAAAIELSTFSAAAQPGIQVVKERARSWDRVSQRTPTVCSQAAVVVSKRAPIQAIKEESCQSTPVRLRSATGRAGHGSPPGGRTELHQWRLCFYVFGGREQGAPGLYRQPISIWKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T092</accession>
    <name>A0A9D4T092_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T092"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7963119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="397" mass="42209" checksum="FAFE12D440CB4957" modified="2023-05-03" version="1">MLPAAGAVPSGPHPVKAPEIQPDQLLKMHAPATSLGTCSASGMQPGATSGHSSKSSAENFSLPLAQGAPSKNISCLDAGLPEGQDDFSDMSDSSATITYMDASVNSSDDSDKGSVVLPPKRCRGSKRYRMPLSSTPVENMPRPNLTLIFKPQNPEQIITRFNPLTLKAAFEAVVPDGVLQVRPNERLNLLAVDTRSAEVSERLLKIKNIGEIALQAYEPRPNNCGVGVIKGVPTDLDQQDIFSALLQRAPVKSVRRLGASENAVVCKQRNASSRHSGEKTPVNNTGASEKAFETTPRIDDTDEFPSLPPRPTAQTSILTTTAAVAPINVPTVGVQQSTAAGASSPSYVPLTPPEAKWRDRKPSHGGDRQAGAKAPGIEEEARQKAAFAFEWSLVEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0C4</accession>
    <name>A0A9D4T0C4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_014226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0C4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048379"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="303"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7962083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="915" mass="101416" checksum="CD1E3BED920B436F" modified="2023-05-03" version="1">MSKSPLDESSSSASSKGPSSRSTKKEADGTTPSLMSTGQVWEEEDNVGASVPATMMPVYEAVRLASDSEACPLPRLVTFATTADTPRSQEETTETVQRRGISTTDTSSQPPGKPRAAKPSTTTDGVASGATATALLEPRRSLSTARRESNASKSTFLSMDSGELSNDNRPESPPAGVSSAISSAPESMRSGPEDGSRGLRSRRGSPEPPVQAKRDPKAVFDFTNILLSPPKRPSQPAKIKECYRAAAAICVAVFVAIVFTAATLIYSFVARDKAEQRVPLCSSEDCTVHADILTAALNRSLDPCDDFRAYVCSAWSPRRQYREHVTSVMDGVIFSHLEGLSAVLRDGSVVLPAGEKARRMYELCEEYFEDGGANIKRLSFILQFLGLSWPEEPEGYQAPSFFDQLMELSLKWQVPFWISVSILSPPDSTRGRLLIKPGDYIAIARNHHRRVILDGDYAKYLQGFYGTLSEDDTTHAEAFFIEETRAVEGDILEQLYSCFVSQMKNPASFPLGDIGNFTANIPSDDWMGAFQKYLYMNPSLAPHDGILVSDTKLLETIDRLLGKYDTRQLRRHLAWLFVQMYAPVFDSGLLWFTYGGKSRASPYRPVFCGLHVEAVYKMLILSLTTVSRLTRHDEQFIQRAYGTLVSTAVRMMNGSEWLDHESKALAARKLSSLRVRVWPPSEYMDNDVLEKHYKEYPRGSESFREYWVTARRLMSEPRKAEVRDADSLPTNYIPAHVNYDYILNSMDVQVGIIDRPLYYPMGTDAMLYGGLGFLMAKEMVKALDSVGLRWHPDGNHVDSIFSQASTSEFRFKDSCLRSQGSASIFPEVPALEIAHSSLLGALKNQSVPLSIRKDLPEMVVFFMTICYVTCATEGFPNPFAADCNKAMRNSAAFASAFNCTVGSRMNPESKCNFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0I6</accession>
    <name>A0A9D4T0I6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_023728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0I6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055797"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7963855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="516" mass="55532" checksum="5EB0FD6188B2565A" modified="2023-05-03" version="1">MSSVSSTNAVSSAGSSPHDLGSDSGSAFSRFSPAGNDIIANIPENRDHEVNSRSQSPDPSTASPEQRHIPASERDNEDALSSVSQTTAVLTTSRLDVGTRVQARAREIEEELSRFCLDAGNRIPVNARHFIMARVFELVELCSDLRANAASERGAVLALKDQLTETRRENTVLHQRAILAESRSCLLPSGPAADDAVPAAFLPAPPGRPVALPPTSAPGLPGQPAPRTYAAALSSGLEPPGQSSRTLPGGTSAPTLPPGLHEHVAFVTPLAPTTTPARDTLLLIKANIDPVEKDIRDVMLRHTRYGITVFSHTLQTLQNMKRAIEENAVTCHAFSMRIPNKRNPHVRFSGVDPDVPPDDFVARLAERNPQLGLDVNTCKVKTSLRERSGTQAIIVEVDPQAFPRILQHPRLSVGWTSIRAVEDLHVATCTFCAQYGHGRSSCPLRHDATREVCTRCGTEGHLGTDCAVRMGDPAVTCAECRREGLEATGHPTGHPQCPLLVDRVCRLRARTNYGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T0Y1</accession>
    <name>A0A9D4T0Y1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_023147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T0Y1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF69">
        <property type="entry name" value="MAJOR CENTROMERE AUTOANTIGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7963824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29938" checksum="9E3F2736E27CA39C" modified="2023-05-03" version="1">MSRNRKPLTLGEKLRIIEEAEKRNGATKASIARDLNIPESSLKTILAKKDSILLNAAKFGLNRKAAKDGKYAAMEKALVEWLRQARSSGIAVDGAILKEKAETRRLAGMERKQLDKKLSVLDAMHYSASAWDAVTPETIANSFRHCGFNRSGACSTSEAALPVDDEPEFGSLELPGSFADYVGADDDVAVCSEVSLDDIIETVRPDTAGTSDEEEMDDAAEASVSVPTYADVLCYVDHIRRFACARDEIGDLLPDVAAIERKLMLGVREKATDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T1Y6</accession>
    <name>A0A9D4T1Y6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T1Y6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058084"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="20843" checksum="937DBBB4F6C8E300" modified="2023-05-03" version="1">MRLKLPTEVNIRQAAEMLTGSWWNVKASTIGNCWRKAGLLETSLTPQDCEPTPRDCDDEAELDPELWNELTEKLPVEAAVTFEDYVDSDCAAAASVELNCKEIVSKVREQDCCSTDEDNAGDAESGTTEETISSSDVVVFFEKALSYLGCCKDVPEGILRKVANVEAYMHQHLLSTHQKKITDFFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T211</accession>
    <name>A0A9D4T211_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013199</name>
        <name evidence="3" type="ORF">HPB52_013200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T211"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="101" mass="10802" checksum="CBABC739408282A6" modified="2023-05-03" version="1">MWQRSSTAHQWVGPPSSQVRRMRWWKSPSSGPQPDGSLPLPVDAVIGGAVSSPSTTTTPSRGLSKSHAGRLVARSACRPAPARWTPSEPGYKRPTSSRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2H9</accession>
    <name>A0A9D4T2H9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2H9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041709"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7963927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="427" mass="46740" checksum="8921144505AA39FD" modified="2023-05-03" version="1">MAKGDRRLKVTTREAFGKRRKRPWNARPKAARPVMLPELTAAALAGGSAGSSSELQPNTCGVSASSAPSSRVGADRIDTAFFTADESSERATTAGNVKVRLASKSATERKFELLGVEMEDDVNDSGTEFLVVDLSVVQEIIGLMPCPACGEKTATLSKDPTKDVVQIKELYKDLGNPPGNIDVIYDGTWLTRGHSSHIAVGCVIEMYTGLVVDHIVLSNFCLGCLLGPKPSEQGYAAWHAKHVPDCQKNIDCNAGQMEVQAALIMFQRSLDKYKLRYTTMLSDGDSRTFHALTEQAVYGFIKVEKKDSVNRVHKRMGAALRSLVDKKAQGESLGGKGRLTQDRIKKITNYYGWALRSHKNDVPGMKRAVEATLRHMSSTDDAPKHDLCPDGLDSWCPYNRAVARDEEPPAHRNSLPSFVCDALEPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3M0</accession>
    <name>A0A9D4T3M0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_012618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051046"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="139" mass="16168" checksum="FB46211A42F7333B" modified="2023-05-03" version="1">MDDAFLDQVPASPQVRYEAAFKNIKKYFKVRKDHPEMFKDLTPSRVPFDAMCRKNRITTVSRHKDPMGRAVALMKTRLFGYDLKELHQLVPDDVIPEENGGTNESYDYEPLQRELESEEGFYQNLGSYGYRDAPTKTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4F7</accession>
    <name>A0A9D4T4F7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4F7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="13942" checksum="C916C6606A2BD8AF" modified="2023-05-03" version="1">MAQPTTDEPLLGDLQPHTVLRSGRTLSRSAPSPTVASAFELNPAPVPTGSSEGFAVPQVAYSTALQMDATSVPRDAVHAPSDFTAPTTAQTPSASMPELLRLRRSYHISDASDTPAHGVSPFFNGGAKQCCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T519</accession>
    <name>A0A9D4T519_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_002372</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T519"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034078"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="15">
        <location>
            <begin position="125"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7971715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="31547" checksum="3B5D5C80099B4821" modified="2023-05-03" version="1">MGPGFSGGKVNKRLGNDPESLLRSDSPGAIADHPATIKKRFISVFAIICISPLFVVFGADLGHFKKNASVPAVMGLRFAGLLQAIVLPLALTMVLFAGPLVLHYFDGVWSLYMEPRYWYLNLRNLIWLRNHIVAPLSEEFTFRACMLPILVPCLGHRAAVVICPLFFGVAHFHHLTERLSRTSNVKMAIMQSVFQFAYTTIFGAYSVYLFLRTGHFVAPFVAHAFCNHMGFPDVSEVFGYKQPRLTLLLLAFLLGLLSWASLLEPMTRPQIYSNELYYQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5B6</accession>
    <name>A0A9D4T5B6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_009402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5B6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039677"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="329"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="574" mass="64934" checksum="73F72334F22C7A7B" modified="2023-05-03" version="1">MPDEKMAVRPLTRMIEGMPWSHYFPEQCVRSALAYQPLPGDVFIVSYPKCGTTWLQYIVYNIYSANLRTAPGAAGVTPQGAVGAATPHGDSVLHRTPAPVARGCFIGRGPDVASGRCPPTRLWSRPASRMGQICALYEELVPMAPCPVQPPPPHQQPLDVHFELGNLSKRRTTACELHQSAVAKLHDRPQGHLLVFMDGSILRKAGRQQFNSTAILWFPAHVTIPTDEGPPNSNEVAHRYAREMTRRAESDTAPSSSDLLLQNTRERLVRYNDITKHYQLGRRILPPPHPKLKRRQAVVWRQLQTHTFPSPVRLRHIFPAHGGVPPRNREQFWDNTPFLEMRGAERSVLRSKPGAIKTHLPFDRQPYSPQAKYLYITRNPFDCCVSYYYHTKHLPGYCFGQGTFDDFFELFITGDLEYGDYFDHLLSWYAHRSDLNVLFLTYEELKGDTSAAVVKIAGFLGDEYAAKLRREPALVGRILEAAALGNMKKVFNSCDFPVTEEKAASLKEQERQAAASVEELVRRPMTGEFVRKGAVGDWKGHFSPVQVQRMLERIRVKTAGSDVMDLWKDIDIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5U1</accession>
    <name>A0A9D4T5U1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_016767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5U1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7972768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="526" mass="57562" checksum="A837FB5597E03CD8" modified="2023-05-03" version="1">MGEIKHGEPERQLSGFGGTLEWRPLVFVESVPYVYSCTLCGVIAAFPKRITRCCHVFCPLCFERFVDGQRLCPLDQIPFADGMIETLDSGHGGVNQLQARCPNATHGCTFVAHLAQLEDHFLHHCKQKNVQCPRCGLDIIQRTALSHFFQDCSGVRKVVSANEDGRAYWDVSCSSVLNRKSLSADSVVSSSATKDYKDEARKSSSADTARDKTFATAGIRKPSQQKREASDRSSSSSNSALPSAQSSIIKTSHGTAASTKQDRHDETRNANPSKIAKGDRKTHSSLSEKKLLEKVESMITRAAENASDAASSAETSVSPETTSSGVMSTSITQVHHNKTLSTEFVSSPSAKNMKHLRKVKVRDTMDKQDADEKAVAAVSPTGFVFCYITGLVGSDTGLACGEELFLRSDSSKFAGCVLRVHARLRRDANGNVVICFKLCICGGTWRRVAELALSKTINLVLVHPWDQAKNEQLPLCLKPDAMPARKQKNPLGRWDFWKPTTELKLRELATRGFVSSGALCVAIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6D3</accession>
    <name>A0A9D4T6D3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6D3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043382"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="410" mass="43872" checksum="00360EA2B65B8D8A" modified="2023-05-03" version="1">MSLSRSRPATSAAVPAPDHPPDEVPNVAAAFDQSATRCVPSPPSADGPAGMPAIRPSAPTSTAHDTSEPSDSTTATLQHALKSDTDMAPSAIRSSTVEDSPSSSIDHHVSTTSTLCASCQQRPALTSQSTAAEVRAPNQHLPNLRDAATMTEASEGELRGSPMAEQPAHAAPVAKAGILHADLRSSPRVPPNPGASTGTGALSDPPTEPTPAVFHDIPLPEFLTGDANQQRCTLNAGMLFDTAQASSTAARRAYLPRGVHLFTTRIAHGMVLQPRRSRVRRLVYPCQHVRRNAKLRSALRRHRHPRQRCARTGKTDRSSYSSMVARRGFTVPFRIVSRTSPTPAHVHPPSTPSAGTSASRADSRYRMAPSSRRGTRLATTPAYFRLVPRPLRFSQSRPPETQGFPIVLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T701</accession>
    <name>A0A9D4T701_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T701"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038856"/>
    <dbReference type="OMA" id="NPQMKVH"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="187" mass="21468" checksum="79ABCFFB82754236" modified="2023-05-03" version="1">MPRIKYIGYPSPYVGKHLLWLLGNLKNFGVGRIVTRTSFERYPEPSYYVITKVVPYMDDANQYGEVWAQTVFRGRRLGVTQLESPQVPDYKLVPRSEEARLLSLPVVDPVPKVLPRYLKMAPLMRIIVERDLKAKGVDNVEPKMRAVYASSYGGSYRIAEEGETPDVEHTDAKNYITEKFRQGVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T749</accession>
    <name>A0A9D4T749_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T749"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028483"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041407"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16036" checksum="A5DE4E2CA4CE7405" modified="2023-05-03" version="1">MCVGIDPYKLRIGKDAALDVDLLPAVTHGDIVNYLVLSTSHVTLQQMVAYKLLDGHNYFTSGWVKSIAAKQLPSQRVVVLSEVTSLVLELNSRSKLPVEGRTSCVAVPCRKRASATQVEPRRSHRSGESKQPTPSSGKLRRAGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T796</accession>
    <name>A0A9D4T796_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T796"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19493" checksum="E2AF1406257163F1" modified="2023-05-03" version="1">MTLMHTHFCTAARAGQCEGRAYETSSKIGTVHRGSRDQRQLKPVRQHVNDQTSTAREWPSKPFEPRNVQHVANSGRCSFRVWGAPSKEGLGPLVRLRGKFNAEAYYDLIESVVVPYALHAPFPNGLYFFQQDRSPIHMEKSTTLVLEELGMMLLDWPPQGADMNIIENVWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T853</accession>
    <name>A0A9D4T853_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_000464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T853"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031806"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7981665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="520" mass="57245" checksum="7D553BA4E5EA3F5F" modified="2023-05-03" version="1">MAQSTGFESTELHGEGETTPRDGATPRRTSSSYSEATIVESLLTTLDSSTMATATKKQLVDELRLRGLRCSGRKDELIARLIRYNTTRQALEPTDSSTNDQAADDDDRQAHLETLSADNARLRAELNSLRAQLNCATTSEQRETSYNASHNASLPTKRVTTPTHGLCHSVPADTTMPSGSTQSSPLNDGTNQDAERPAAPTVSTHGGEPSMAQILAALVNTQALLANSLSRCPPTTSPIQIHSTSDTSSSIPTFDGTPQQSAHEWIVQVERIAALAHWTPSLTLVTATSRLTGSAKDWHSAYGSQHDTWEQWKEALTLRFKRKLTMQEFLELQTKRRLQSHETIVEYMYSKNAILNKAPYRLAEEERISLILSGIEDDTWANPLAAQLCGTVTELIDRAALLDARRRMTVCADNDEKPPPSTTSRGATSSKYSDRLCLFSEFKMSVVDVSTYEIVYDHTLLACFGACRPVGDVLLIFLFRRRLDTTVKSLSEAISSVEEPSEVSMWTMLGPKWSLASEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T889</accession>
    <name>A0A9D4T889_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7977065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T889"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7977065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="465" mass="50067" checksum="2B4104AB4422AF3B" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRVWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGPQPSHDHDLPSPATTPPTSRQATSASIPAPDHPPDEVQELPAATGHSTESSVFLTGSADGPSDVPAICTSSPTSMVHDTSATSGSTTATSPHALESAIDRDIVTPAIRPPLAEALPAMMSDEPVFPSTSTLCASCQQRSASPSQSLAAEVPAPNHRWPNFRDAATMTDSPEDDVPGQHTPELTAYATPATEADIQHADLRTSPREQTTVGASTSTGSSSEPAAETTPAQLHHRFPAEPLTQDTIHPTSDCYASALVATATTPNRHTCLPHATLRRRSHRARRQTQQKLHTRLSTIPRGAVISLKGIYALRRHPFVRRHVTDTHLRRRAPRHTTQWSTLRRRLQRYLHPPSTASAGTSLSCAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8E4</accession>
    <name>A0A9D4T8E4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8E4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049852"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="123" mass="14146" checksum="084FA04E8D92E9F3" modified="2023-05-03" version="1">METLKLKHKAERLKLTRLITKLEAMLTQVSVTEEELCILNEHLKHLHTDLRATDSHIVPLLSTMEAQAELDQVVDYNDRATVTSAKLWYRIHQLQESKKRALLSTEPVQCTPSPLSNFRKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8W1</accession>
    <name>A0A9D4T8W1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8W1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026599"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038846515" evidence="2">
        <location>
            <begin position="23"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7982940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="973" mass="107261" checksum="66465C0EE4676FB2" modified="2023-05-03" version="1">MFQVKGSLVIFTLLSLWSGCFATARRRRTKDVVSEACLNEGVRVSECRAAFITELEMMHSMNQNNQHTNCTLYSKLECCMVTEYGALGCGDKEAINKAISFAIKDHQSYDNCPKGLCDPASVNGSFKIMRDMDENLHESKNSTDMPKSSEAKTSSVAAGVPPAAPAEVAPVNGAATSVSSLEKEAVTGGAGGHDALANVKVPISIEIVKNISLSDIGRTSKKTHRRRRHHRKVPDASLESNTRSGSGVASTEEGKNADAAGKSGLEKDEPKNSKLSDVPEISLAVHRLEKKHDISSDASSFAHESLEDRARKTTTNQTKVSDTKSETVNLSSTANASAAHNQTAHNQTLEEELSTSGRRHVDNKTGALSEAAVNLKDPKQVFGSGPLIEVKGHKGGSVEKQMVHAYETGESGENIKGKNSLIDDLVDQYGSGGSDYDLKYGRDLKKRHRPRFRDDDDAPKVRRKQWDGDEPFEVDTTRDPFQEYPSVKDGDPRTGGLYVGNRGRRHSAEEENVRIARHKKVHRRKPENDYNYESMVRWKLLEELDSILDPKNSPDAETMNKPSGPEFRHEKDDDMDQWKRRLQALKVQVQAQSGERIVGGAGDSFRDADAMRDGEMYYRKYRRQSPLAYGQGYEGVERPIVKDPLIHQAKKRFWIERQESDSNKSAHDTEHQGAAGIHLRPLPEAPGRELPPAVETAEKHPPNESMGVMREAAPYVAGHRLISSDSRASQMSGLGARRFSNRRAARARRLRGSRGSRKLHKSLKDTEGLKILRNDDLQGDDDDDDDDDADDDDDEDDDEDEKEAAGIKKSTLPAISPKGQVGRVDAAERPLMSFGERVHTMEPTKTTPKKEIKPAGNLVGSAESPDCVPDTLRAHTDYCRGIYTKHQLSIEEARKIASKKTMACYKLESIKGCLSAGSYFSKCVGSNNNEFQELQGSVMSQMRDLRCGSSVLSGSTMLLVLAVALNHLLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9C3</accession>
    <name>A0A9D4T9C3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9C3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035654"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038494743" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14656" checksum="121E4119C3DA1384" modified="2023-05-03" version="1">MGRTCLLVTACLLVAASTVVRAQKRAGDTDFYFGTRVRCHTCDADFTIEKFSVEHPCLVGQRERDVAYCSVNSNFCKVEVTRLNGVLVTYSRRCADKCSPNCYEKGFGMLREQCTYCCRRNPACGEKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC94</accession>
    <name>A0A9D4TC94_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC94"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="23863" checksum="1316F2FBEFE41D85" modified="2023-05-03" version="1">MKQSLNYARPPSGQRRLRRTRSDRLLGMISSPVRVRDGSPEPRRLGPNDLTPVHQRTSRRLRGEPPEFPLLREPAKEPPAVCGGNTEMTSPVAATHVIVDQPRTPEPFHGDTQQLNSNPTTISSLAEVVREEVRQAVREQQPQAQPQASLPVQPAISYAEVLRGTPGRTFVTASTHLPEPRFTPPPPEMRRTTAPSPHAIGSREIVTRKERKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YP59</accession>
    <name>A0A9D4YP59_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">39S ribosomal protein L13, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YP59"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031935"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17286" checksum="196EF27B52A22706" modified="2023-05-03" version="1">MISDVLQGKHKPIFSPTSDCGDHVVVTNCSEIAMPWYEWKYRMYYHDTRFAGGRSWTPAWQVQDKDATKVLWKAVYRALPGDLNRRTRMARLHLFTDDKVPREVMENISGQLRQLRRAPKKLVEYSDEEQAKFPKVFDYPDDYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YPH3</accession>
    <name>A0A9D4YPH3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YPH3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029388"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36192" checksum="E51A7A2C941E7C1C" modified="2023-05-03" version="1">MSRFRCSEPNEYNGAKYRFMATDMFGEVLQKILDRRGKMPASKTTPSLDMLLIDVLERVHSYEPIHADVKAYRRLLMFSEGGDNRVYLLDFSLACRYTQNSKHKEYKEDFRKACDGTTEFTRRDADIGVHSRRADMELLEYNLLRWLCCPLPWEDNLKDREYVSQQRCTLLENFPLLMRKCFQQGDIPCGITVFLQYVASMKFEDTPDYGQLNRILEKEIEAPALEPDSRLLRTPPRRPRRSSFSPKKSVLEEIILAEDSMDVRVNENLVEEPPPANVAHGCTTPLQKNNRRSPTATKSATRLQGLVKVEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQ92</accession>
    <name>A0A9D4YQ92_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQ92"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9805" checksum="E74F956D7134D128" modified="2023-05-03" version="1">MNPLQTLRLFILYQIVHLSGHRNNPSREAHQENRKEYIQEIPTYASKLRTPMRPQAESNRADRSNVAQASTLKLHVSLSGPQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQN3</accession>
    <name>A0A9D4YQN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_019571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQN3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7984343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21246" checksum="A8E977475BC534CF" modified="2023-05-03" version="1">MDAKGGICSSLGQRVNVSTAQEPSEEFPKEWLLCLCCFAAVFLALLVLFIVYALVPYPFGPQSLVAERRCGDIPTWGEWNLKEDEDSAIVSAAALNPRNTVPKIIQDLGLKVSPTTVNLRLAEAGLKKRVACRKPLLLELNQSKRLQFAKDHEGWTAIEWERVVFSDESSPTTRWDQRQRVWRSENCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQR6</accession>
    <name>A0A9D4YQR6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_022219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQR6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040025"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7984521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="349" mass="37184" checksum="A3642E98538ACE14" modified="2023-05-03" version="1">MNGGTTTTARYAAAGVPEAAALPAACALRSPTGRQPKCARCRNHGRRRLVRGHKRQCPFRECTCEKCELIAERQRVMAKQVALRRAQAAAESTGNQLITDDEDDTNQLPANAVLGSHVPPPSQWSSGDVMMPDPTSPFAQATSAFAAVGILEDLRKRRYVQDALACLMNALAVSGADAPPLVYLYALLRETNFSVDRAFSRLLEARLEVQSLAIQESLQKQSAGLAVASAPHMWSSVPCQPCSAPAASGLLAMPSLLSLGLPASLPQPLPVGMCARPSAPTAHSRAHAASLAERPYPDDRERRRSSSGDSSGDELLLDVDSELEHSPAFKCSPGASHDRSRLCAAARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4P8X6</accession>
    <name>A0A9D4P8X6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_025450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010002077">
        <property type="protein sequence ID" value="KAH7931664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4P8X6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026691"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7931664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="353" mass="39681" checksum="BF763B15933CBF40" modified="2023-05-03" version="1">MEAQRTAQYHRLAQTRTGRAILNRIGMEIPHTSPREVAALPQDVMRKIRIPPAPRHMHPQNDQERRTARAVALTKSHRNHPHAYYVDVAKYHNVKNAYTAAILRANTGELDSAGSIRCRTPAQAEEYAIALAMHTTDCRTIISDSKTAVTNISQNSLYPTTARALTSTAQNGRLATNVTIKWFPAHAGKLDESVGPNRNEEADREAHALTRRGLPSSLPDMREADPAEAKAENANSEEFAITKYGEVLQWYRASRSKYPPPHRDLTRKEATTFRQLQARAIWTPVWAKHVCPEIYNTDTCQRYIEMPDKIGNKITSTDLETQRAVVQHVLELTGRNPKRRLARGATDKGGCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAF4</accession>
    <name>A0A9D4PAF4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAF4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036018"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039235406" description="CUB domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="78531" checksum="8C68DACC2C1E1427" modified="2023-05-03" version="1">MCLLILLVLGTPSCHGSEGLGDCSGRFVVEDSTVKLTVQQLVNSTDSLVECRFIFEAPHDSGLLVFANDIRAVNDSEIPGCPVTIYSNEDASGDPVVSLCGHYATMTIPVPSSVALVVYKPEFNGVPYTLTMDLQVTLTGGSNLRACGDSQVTAVSAVPIKYSVGFRADAGSGDASDFCDLNVTSEDSGETLGTRCVLTSEGVCDYAVLVNNGSVAESADSVDLAAVGGSATVRLHPAGITGVLVTVLPAGFVPLTSLQPSPVVLPPEDGTTNDTDVNETSTEGPLVFRSSVSPRNQPPGDCSGRFVLEDSTVKLILQQYINSTENAVDCRYTFEAPEKSGLLVIANDIRAVNDGEIPGCPVSIYGNVDARGEPVFSLCGHYSTLTIPVPSSAALVVYKPEFLGTPYTLTLDLQVASTGGSNLRACGDSQLNAVSAVPVRYSLGFRADAGSGDASDFCDLNVTSKDETLGTKCVLTSDGVCSYEVLLSNGSAAELVDFVDLATVGGSATVRLHPAAITGVLESNVPAGFVPLTTLQPPPTDTPPVWNISTPAGVLVNSSSTESATSSGVVDDQTSTAGSASTSTKNPSDEDDVSIVVVDDSGATADCSGHFVIEDSTVKLFVQQHVNSSEDATECRYTFQAPPKSGLLIIANDIRAVNDGEIPGCPVSIYSNDDGHGDPLFSLCGHYSTVTIPVPSHSSLLVYKPVFRVTAFATMMSFFGTEVPRHPKIMSILKLLVGRLRSDFILQAHLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB81</accession>
    <name>A0A9D4PB81_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB81"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29769" checksum="2203887FFC5A40B7" modified="2023-05-03" version="1">MELAALNAELKTFLTDEQVAEDCDFVIEYEDAANSALTLLEHHMNRLKVSSPASTAHPVATTTGEDPPATSEREGTNATSTTITLRPPQTVRGKVLTYYAAAQLPKIQPKHRNTLSPAQPQKPGRRYQAQLCTRRIVSRHCRTLVRPAPSTVTTAVVAAEVPEQAEAEVGIEDHHNRRSQAPTIRRLLLPPARSLKLLQATTENHRMPQAQRGDPQEDIKDPRNRLRGQAPHHHIKSYGGTNTTANIQLTRDAVMHAETLVLNCLNHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD02</accession>
    <name>A0A9D4PD02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD02"/>
    <dbReference type="OrthoDB" id="6496574at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="569" mass="62753" checksum="7DDC57914D15A1F4" modified="2023-05-03" version="1">MSRKNRKSSKRRSSKSKNSRSDANPQTKPSEKPTAQVKPCVAESKAPPLVEVNDNVAQALVKNEDTPAVPAKATAYKSPFDGDPDETSNDSSRWPHQRAAWDARQTSGENRQLNGAEESLADRMQRLAASQDVSPSYLGPCYHRHNDQHFQKGLPTRWEEDDDGFLPSLRFGSARTAVGTTALIVPIDGITQVRSLNCIRVSKELETIVPDGIRRVRLNTHLNLLAVDTLRTEVTAALMGLRRLCGVAVEVHEPRSSFKAVGVVYGIPPGMTATDIEAAVRSPVPVLNVRIPHPPSPAIMTFASTQLPEHVDIGFVQHKVHMYVDRPPRCKLCGRIGHVMAVCPNPSPTFSKGTSGASNGDNNSNAHATGRQRCLNCGQEGHDTRSKTCPRWLELIEVSRYRRANDVDTRTARTAVAKSLEARSRGVMDERHHVIKCINSMLANPTSADGASATPRNSAQQGRRVYTVEELLRIGLRTPVHRRPQNSSMGSRGLLVLRTARSAASVFLQRTFTALVRIFVEPVRSFVTTYYERFTKPVGSGLFRPWENQSTADLPFVVKQQKETTDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PD93</accession>
    <name>A0A9D4PD93_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_014628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PD93"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030509"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="752"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="822" mass="92770" checksum="FB5780197997C56A" modified="2023-05-03" version="1">MASPTPRDVLINRLVDRRPACASHNMYRSGDYDFIILLAFLAAVIVVFVLFFQYDFGQRLRQRVRTKRPAISITYRAGIASTSPSEHQAAQPGSLREVPALSEEPPAEVTTPEERAVSEQPITLARAEEALTMMAPVTIERTLGSCDGPGCREVADELRATLDDSASPCSDFYQHVCGKWVRNHTPELGEALVSERTLRRRRLESQLLVELRSGTDDGSLRWPLRLWRECSATTGEPQSHDVLRTIFAMHGLAGFPFGAADRHRDLSTTAAKVLSHSAIPALVGIEIVKMTADDVPTAGGHKPRKKKARKGSSSVVDERPSGRWVIRVGPPQPLFRDFVSMRDVQDEWFVAAVQSISGRRDMPELVEIEQALVDLAGERAGVDDYVPMPVARLQHSRLWNWTRFLRTALHGVTTIGSRTTVLIKGGSFQRRFKLIVDKYGSASLHNYLALRMYVRYSPFLDWKKYRALVDVATVRLPGWEDIDPPEHGVELRCLRFLYRLVAEPFAYIIWNANISRSLEHLESDLGALTNRVVDEALTFVGALNVTQQLTDRFRNVVSGLKHQLLVPAWMRKPSLRMKFSELVFSDAGTSPIVSWNGVLGATWRNAQRRLVDRGFETFWRGSALGDEPWLEEDEGYLAVAPGSVDKDLTGDAFYAHHLPRLGLDLARAMMGHFFRMASRLKRRYPAAHLRMELLADCLRRQFYGDKHASEVSAHHDAIDVLALPSVLHAFRRRFQSSGNGNLSMIGDTRSGSRPTDRLFFYEFARSRCEAYDDAYSHLRTYKGTRSPAPFFVNGPLRNTREFARAFRCPRGSGMRPKRICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDU2</accession>
    <name>A0A9D4PDU2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDU2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7936282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14137" checksum="EC016F44E624C344" modified="2023-05-03" version="1">MEILKKKRKVMRSQVTRFTNDADKIPSSASAIDLEEVSVLVERLRRRIFLGFFFVGLGVATGPFAVAFFDAENVGVAAVVTVGEGHCVEVQIPFSNPRVAARLAAVIVLIFCVGVHAVLACIHCRDLVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEA5</accession>
    <name>A0A9D4PEA5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEA5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="74" mass="8481" checksum="257AA9FA4FCAE03E" modified="2023-05-03" version="1">MEPPLSVGLRFGSRPISGVAEFFRPSNLRKRKKLGNVKEVAQVIDDAEVKILEPDEEHEDRDHRRSQEDPWGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFN5</accession>
    <name>A0A9D4PFN5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_023434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFN5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049921"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7936449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="266" mass="28130" checksum="CF1D09D89CAF01BD" modified="2023-05-03" version="1">MSTLMGLHPLKWVSRCISAADDDRYIHDDKVEAAHNHDHGIKAGDGIAAVAWMIIFGDGMHNFIDGLSIGAAFSESLLAGASISVAVVCEEFPHELGDFAVLLSAGMSTRQAVAYNFLSALTCFLGLGVGILVGDLTEGAPHIFALAAGMFLYISLVAMMGELNEALDAASKEGFVASCSQKGHRWTLVCVTNWEMKKGAFSQVKLFLLQNVGIGVGVALLFLMAKYSEKINFEYFSSLPVGVSLAAASFGGTHDDARAVFGGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFY1</accession>
    <name>A0A9D4PFY1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFY1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036047"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7938959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46132" checksum="8A716822A1AABB55" modified="2023-05-03" version="1">MACSVDGVSAAASGRGVRCSGPPAGYKFVLPTLPKDETMEPCVFLHCDVGGRPYRIEDFRTPLEELGVIKAVSGIGPYQMSHVWMVKLRSSEAKNMLLSSGEIQVKGRYCAVIDPVKQELTVKVHWVAFDVPNEAVRKVLSEYGDVKEVKLEEWSVPGFEQAESTTRVARMTLHEGITADELPDLFKFQGGAVLVVVPGRAPSCLRCRMKGHIRRDFRTPRCTTCRAFGHERQDCVRTYATVIGATPKRQDIQDLMNEVEAEEAASPTTKGIIETSQGSGCAAGTLAAPQEAENRRSEKESTAPVATEPSEELPAARSVVRSRATRRDALVREGDYAKVEGSTSVDEIEQRKETDKVEGGSFGGDQGALVKMDVDPALVKRRREEDDAEPEREQRQLENGRRQLERRGSTFPAPEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGH1</accession>
    <name>A0A9D4PGH1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_007085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGH1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035590"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="277"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7939125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="829" mass="91915" checksum="E3B4FC2CFED3ACA1" modified="2023-05-03" version="1">MDVLTSILWSGTTWIPVRKEPLRDITMRRAKTCLRTAACLLKKVPYKISRGLLKQRRHCTCCAGIDVVVILLSCLPFRSKLISRAFSAAGIARPGDRHVTASGRTGLLESILTPVAFSERPSEVFFLHGIIIGITPNAIGTCGGPRAARFTKKNPPLSNPGLKPDVDMAAPAAPAGSSAAKKVKSPIPEEKSTKKRAEAIKSPKRPTSPKREADKAYRRKVFIAVATLVIAAGAFLFYLTLWTTITPAHKDNYACNTPICEQVMKQLSEYADSAINPCDDFYSHVCGHWLRKAESSTFMSDAKKQFIARRHELLISPFNSSDPNSDVFETARAFYRSCLDMFEAPVVIKTALRELYTRVLKDIAETTFMNKVVDELIQLDRMWDARVAMKGAPDFPKRVADLSCGPFTADVWGASFAEHGARSDTDVEAIHFGLTCSFMEAVFVNASAQARPLYLLALMAAQALTLDFQLAGSPRSRELLMDVCQNGALHLFGEMWLHAMSMSLSLKRPSVQDIKNFTNFGRRLQRVVLERQWMSQEDRAKSADRVGSYQVFVFPDSAMSTQQLECSRFGQGDKSLSRLVLSNTFIKNIVYIYKVELSPSCAENQKTAIPTSTQEAMLGTDIAIDILKRTVIVPQFLGAEPLFYVGDVEKFINIATVTTLVSGLGAQLASRRYAHVPVIGMNDSGQKPWSDETLGKYNNLSHCLAKVYKLPGKPLSDIATDAVFSLMDGIEVAKNTKSEFDGENVEENPRRQLATDALFFKRACLTLCASHTDDSDINEVIFGTAYAACNYGVGRLEQFHRAFECTEKHRMRAILQCFDPYRAKDTDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PI96</accession>
    <name>A0A9D4PI96_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_011100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PI96"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040281"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7943737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17601" checksum="89633C23BC2A6C55" modified="2023-05-03" version="1">MEKKKINFSEEERAVLLDLLSRHRSVVENKRTDAASASRKRDSWKKIEDEFNSRHNLKKCWENMKDKWRRTNAEDMRERFATGGGTPPSSEMSDELQETSLHPCLFVCPATAAGMPGGSQSSNQLCTPSVAALLSQTQDTALEESAGFGAATLYWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIY8</accession>
    <name>A0A9D4PIY8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIY8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8896" checksum="FBEEA088C713FBD0" modified="2023-05-03" version="1">MEYRLKLTEEEGRSQEIKLQIAQLQRDSPPRTQGIGSDATYQSGQTKLHRHYAQMLTDAFPKFPAGGEVPVWFESVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJH4</accession>
    <name>A0A9D4PJH4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_018296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJH4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7944326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="360" mass="40256" checksum="FDDC442D238B004A" modified="2023-05-03" version="1">MITAPVPSISSCFSYHGSRGAWSLSILLMAILKTSVNYEEWSWWSDHEEELAGTVNVNMFQIVRGIPFWCAVFEGALTLLPYCPASESLRLHAAIVTIAALSSTVGTAVSFIITQWFLGQFTPWYWDRLRKTVIGQLFLLVAMSVAAGAKHYASKQLYDLPGYTFAMPALHIIFVFIEVIFSLTSVVTYGQSSYELKHKRFQVLETVAVTEDLRSQRPFGPLSELKAYLVAGVLGIKSPKPDDTLTRSPPWKYRLEGKRCGRRREPAVQTAQGVGSRAAADEPRRSQWLNAVPMIRRQKKEPEKLMLCSLHFSPSESDYEYNPALGKALGVPKRGVLSRSAVPSSHSRHRCPCRSKPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKB6</accession>
    <name>A0A9D4PKB6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_001837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKB6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030469"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF3">
        <property type="entry name" value="PROTEIN CBG18017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7946593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="238" mass="27197" checksum="BEBB23DFAA48258C" modified="2023-05-03" version="1">MIKGFSSRNTKELIEKEYKMSNTTRTDWRNYVREVTLAELLEQPPMGGVGQVVRIDECLMRGRRKANRGRLLTGDNVPPRRRNNHGGVSDKGPWIFGMLCVSTKEPRLFEVDKRDAATLGPLIAKNVLPGTTVFSDEWAAYRCIPGLVNANGTPLNLDWHTVNHSVNFIDPATGANTQHIESEWQKAKRRLVRNGNKTTPALMRSHLSWLWWRSVNARPNVKDKFLRLIKAIARRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKR2</accession>
    <name>A0A9D4PKR2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKR2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026235"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59827" checksum="872A85F00BEB5244" modified="2023-05-03" version="1">MNISAERNVVAKTVTVKSYGAPRCFSEGTVPGLSTIKCVCRNGWNGVECSIPDAVWTTREFQVWYSSGRITRRSRPRAIVNGLVFNHELDLLEIRINELGNAVDHYIVCESNYTFFGTAKPLHLRSNLSAGFLRENAHKIILVTVGVYNYGDGDPWAPENHFRRSIWLEGQRSLKHLRDDDLFMIADADEIPSREVLLFLKHHDGYGEPVGVSLRWFMYGFFWENSRPVEVGGACTVAFLRNVYENDTLKLRRTDSYVYKSLPHTGTTQRKWTIMGAWPRYAGWHCSWCFDVHGIQLQKVADLQRKVKRLQRKNRDLLQENSRIKKGIRGVFKEDQRTTTMDAWDRRRHAYRLGVFRVLSRATKALPMATGDHATISFDSHGELQENVTIEAMDDSVISENVRNIPTTRSAINTPLVDEVKATGVTDRLLPPTEVPLMRRIVEATILLPQVPKLTSSKIPFSDTVQATVGLLAESPSSVQTRNHEEVAKNYRPPVQLMGAGGAGRYYQFMQSSGECSFQIDNESTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL91</accession>
    <name>A0A9D4PL91_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL91"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049018"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="93983" checksum="E41639EA9F11F607" modified="2023-05-03" version="1">MQIGSHSAPLIHLQAPGFSDHRHEIAQPTQRASHHLSSGTNISELGSFFSLKRTFENHAPAASVPNALCGAPRNAANWAGARFAGTTAIDSDPPDQLDCMDADDVETEDGVGPSGYSPGPSGVAEASNNAHLRVPQSGFPYKRRHISTTRSGLTLTRCYTNRTPSPLAPGGADTTPQIQTSLQTLELGSRSYEVSAYVASPDNSCKGVITGALPIPTEDALMNDTVTYAQGINIIQARAFGTNGAYAYTPSRAGVFPDTFTFKVWNFDADLSDQSPKCATAASEPATDTTSAHIRRNDEHHDGCVPRCLTCGSDEHATIDLGCPARQRRPGPRTLRDGRQLPEKPNTPPLRKNTEELPPHNQPRGSSQNADSQGPTRTARSKRPKIPNQGQQTSQPIQPQAPPPIQTPAHPSRNHPTPSSQCGAKSNATWPALPQRQSTHAPGLAARAAAPSASGSATGGHLNQVSQSQLQRRQDPLADSGKSPVEQASQMSSQSTPPHSPALVQQTCAQYFQTPEFTQGLTQLVLKFVSDSLEAVKTQLSREQEQALQRMETTFSHRMEKIDPRSRRTAHIREFRLPQRLNMANSSNRQNSGRAGRNLLRTLRLEPSGTMRNEEAWSPIPIKVAAHMQLKPLPRNMNRQRHPGRRKARADYYIRWYRNRDDVLYVDAAVGPLEGTATAAAAMTEDGRINTSASIKTARPDVAEGVALALAVAHAVADSTITEICADSQSAYRYFRQGIAPNTVSRILRNIPSLPHPVTITWVPGHECIPGNERVNAHVRGLSIRTLEDHSPKPVTKPEEGICTYHQITSYYRNGRRDLPAPHYSLTPNQSSRGSTEKKDTTSVVTRTDAYQISRDVPCIMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PLZ3</accession>
    <name>A0A9D4PLZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear receptor interaction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_012192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PLZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034387"/>
    <dbReference type="OMA" id="FRVRYGN"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7947463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="90694" checksum="1F42AD8763678CA9" modified="2023-05-03" version="1">MFNRKGLFWKSEGFHYGYSTPYQLFDAAKGSLSFVQKLRLEVKLPVHNGCVNTICWNDAGTYLLSGSDDQHLCITNAHTHVILAQIRTGHTANIFSAKFLPSSGDRLVVSCSGDGAILFSDVERPETSLRNLFNCHFGTAYEIATVPNDPHSFLSCGEDGTVRWFDLRTKTSCSADDCSEDVLINCHRAITSIAVNPLTPYYLAVGCSDSAVRVFDRRMLGTRATGNFMSNSMDAMTSRLTVPEFEGRSHRITSLTYSANGQEMLVSYSSDYIYLFDAVGSVQEEPKSYSADGRNCSASEAKQKECHVSMKRLRVRGDWSDTGPNARPECEMRALGEQQPRSLHASLMQRMSDVLTRMFNSSTGAGRAAGAPNRPHAGTFLASSLSSSSSASPGHSGGDSSTDEDIEATVARHSRSVRLARAIRQRVREKMASRAAQRENAEREQEAATQGSSSNVVALDLSQPSASTSGQASSDNTKQPKQLGDACPACSSGSVRQDSSKSASQPVLAAGLRRSPNQSDDDDDAAFQDSVESISENECFQSAAENISPAGENGKDCALLDDLSSPSRDRGATSAAVRDASADNTSEDENTNLNDDSAFHWRRQSATPPRAPSEASPQPTGNSTSPASSRAHSVSRQPTMPDSDSVLRAMAEDLHLEKECVEEPSFTRTVTGPRARKRYTGHRNSRTMIKEATFWGNEFVMSGSDCGHIFIWHKETCELVMIMEADHHVVNCLQPHPFDPVLASSGIDYDIKIWAPLREEPFFDAEKAAEMIKRNEVMLEETKDTITVPASFMIRMLASLNHLRSSGSGIQGWRRLVRDARTDDSDSSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PN15</accession>
    <name>A0A9D4PN15_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PN15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038123"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7947679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="232" mass="25336" checksum="1DDCAE3BF59DA927" modified="2023-05-03" version="1">MSAPEYALAPRPKAKPQVQAPLAGSTFLQSSSPPKTEKSKSGLKKRKRRKKARGDAPRKNDRNSEDTTVILDINPLVNSEAGGVRKVVQKTLSESLIITYRDSVDMEHPVDALQRGMNYFNRSHLNPSLERCSVPYSCCKRSRSSNSGSVAASLHCGQGVLNMSDAWHKVHIDSCTDAVNIKDNVIVIGGGSVVVVILLSFIDMITNTVIDEIDIIRSIYVHAAAATNRQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNN7</accession>
    <name>A0A9D4PNN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_019983</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039684"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051060"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7948261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="381" mass="43084" checksum="A6EB04FE0B662488" modified="2023-05-03" version="1">MATDTAPPQDATKRLQTKKQTLDDAYAPPANYLEIDVGNPMTHGVARKRYTDYEVRMRTNLPVFKNKESTVRRRYSDFEWLRSELERDSKIVVPPLPGKAWKRQLPFRSDEGIFDEEFIEERKKGLELFINKVAGHPLAQNERCLHMFLQEPVLPEKGRFYELARRSRPSLESARKEPGCAYKLCAQCLTPVQVASAGPKGILCSVPCLEAFMRAKEARQNVRVSFRDGTRVPAYTLPSGQPLQSQPQPQPRDELGRNLPEDVYSFIQEVARIQALGHTVRTDGLPMVFKQDGSNAQARSLPIELLRIAMDVGKPTKSGNAQQQQPQQQTQRVEIIKRVPTTTGERVSARPVMLSGGRKVLLVQRRDPPPPAPQRGSAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP47</accession>
    <name>A0A9D4PP47_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP47"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032819"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF146">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038514667" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="19421" checksum="10475D3F9A3597AC" modified="2023-05-03" version="1">MFLCLHGAGVSLMSQSLAELAYLSVYSAPAQWEVRIHDAWKPLTLELATWLEYRWSSHTRVAELKDYVQVDFEKMQMTKPFYGPLQRTYQPALWLQYRQSDHQTLVLFKVQRIQLDNQLPDAVFPIVLHRSPATRQPVLEAALLLRRTYQLNTVKYDVSVAWCHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQN1</accession>
    <name>A0A9D4PQN1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_017809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQN1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036533"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7948027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23552" checksum="4ED32BEBF3CAB394" modified="2023-05-03" version="1">MLIANTSATQQSSSSTKRKRHPSVTFPERVFSGIQPSGVPHLGNYFGAIQKWKALQDSGSDCIFSVVDLHSITKPHYDPDKLRENIELMTASLLACGIDPERCTLFLQSQIPEHAELSWILGCLLTTARLQHLPTLKDKTAGMKETPLGLYLYPVLQSADVLLYKATKVPVGKDQLPHIFLMQDASELFNKRFGLVFPRPEALLGKHAPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRB2</accession>
    <name>A0A9D4PRB2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRB2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055396"/>
    <dbReference type="OMA" id="SSWNDVC"/>
    <dbReference type="OrthoDB" id="6506930at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7951615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="498" mass="53997" checksum="481BB66DE21DCF2B" modified="2023-05-03" version="1">MSSDVSLSSGGESWPPTKSTQRQLTISWIQVITGIVQLYCVMCHCVLLMLIAVWMVIKEVSRRVSVLWVSWYSDFKEKRPAALPLLLGAIHMTMVSKIAPQTKPSAEPEGTEDADDTEVTEDVSDENDRSSENQSEVLDVVEDKAEECHSSAPTVSASTSGVCSSSSPEVSRVADVTESESSASLDPPLHNQPNQQLSKRAPCSISAVVEDKYACGLNRSTSSSAVSIEDLDDSSDDDGVDGFDERSKSSNKRQDSANVSCTGSWKLKSAFQRASGKSNEIQSCFAKPKAQVTQAPCPEKSKFSLGPVISNLRRVCCRTLSAINKEFTECMSPQSQKSRGKKTETPARNTSQVASNREVHHQPHQDAKGDASKDLSVPEQRTSLQSSWNDVCSSGTPTSSDSLGEMHRGLLDSFSEAESSDFPNRQSADHHFGETAPEKKPTLFSGDADSADGNFEKGNSDWTTQHPQSNSFFNCQGTEANAFGTVFQTDGNSAGWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PS95</accession>
    <name>A0A9D4PS95_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_020496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PS95"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030315"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7952241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="492" mass="54506" checksum="BD38BA0F63FA4EDB" modified="2023-05-03" version="1">MTAAVRAATTSRQLLLCEAREMDWNSTETTTTRNALRTEELVVLRGDAIEEAAKASKRRPETSSDQATEPKRQRPGSCRPKSAASARHESRDESGASNPEEGSAQESQREDHFGNLTRERRLQELRFEMERLSQMMSGSSRGSEPAVGRRDPCSELRRYSKVLTGVLPKFPTEAEAPVWFESVESALEAYEVPEEFWGRLVFPLVAERVPFLSTRLSPTEHKDYQVIKQTVLDELKLSAGEYLKRFSGSGKSANEGWRPFATRLESYLHFYLDARGVSTFEGLVKLLVAGHHIGGSRALGNEGGSLVVLLGLRLRVRHVRPRPRQCQQCGRFGHVAEACQRKGACIRCGRQHLEAESCKPRCEERRVATLMAATPTPLSRRAVKAAVREESREVRSYAAAVKNKLHEGNTTDPGLQRPSPAPRRSLLPTASSPRSSLPAAPPATPAEDPRDTLIRNLLATLQAVMQFLPEEHPLRTTCLQALGTRSGAPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT05</accession>
    <name>A0A9D4PT05_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT05"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031602"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="211" mass="23604" checksum="F8ED50CD742473F5" modified="2023-05-03" version="1">MSVMRRSRLDFLLDMLDFDVGSASDRVPEPSVTWWRESVPLESVLTEHRPGVRRSALGPFVLRRQDLMAVLVCQASNSNLTSPLTTSVTLDMNYNDLIPGSDIFAEFRLQVLFPPKLTLRLASSLRRSQLREGQDVYLECVVEANPPVSDVSWWFGDRELFTDSTGGVLVNNRSLVLQKVRLDARGPYSCSAANSQGQGSSSTLFLNFQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTN3</accession>
    <name>A0A9D4PTN3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 21B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_010277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTN3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032803"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043488"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="6">
        <location>
            <begin position="289"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="8">
        <location>
            <begin position="633"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="7">
        <location>
            <begin position="782"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="911"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7951530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="109279" checksum="47439336810FAF50" modified="2023-05-03" version="1">MFALVRFVEDDVDKRQYVIPVADIEDFDPADENDFSNRTTYRCKWHDPDDDANDGTYTIQILRLAATEDDMKEKMRQKRVNVPPINLSDLDNEYGGEDSNISQKKKVLRQESKKKRSNRAASKKQQFDDVLRQHTVHALQSNAAVPNRTSPVKFHLCKGVTITSQQASKIFSNKKPTIVVRDCAQAIWGLEALAHRTVSGRSVPGEETKQLTPEKVQVVNGIIWCQLLEDQNDVANQQLELLKEIHKTSSMPSELLYLCALCAQKTQEKPEEVLNYLGQSVDNHFAKLEPVDSGQTIPEPLRRGQAILQPVLRSCPGSVEAVYWMGKLKYLSNDLVQAQSLLSKCTQQYSSFTSAQLLLAQMHIHQGNTKSASQLLETALSYDFEVREKPIFHIIKAKILKEQGDYQEAVQLLNAAMALCTAPVSTTSRKNRKQELTSSDKLSLYLELADVYGKLDQQHEAVRVMQEAASEFRGTPEETRVSIASCELALARGDVEEALSLLRNIGPDQPYFQQAREKMADIYLNYRKDPRLYASCYREIIEKFPVPQSYLMLGDAYMKIQEPDNAIGAYEQALRKNPKDSAVARKIGQALIKTHQFERILLALAKLEMTSNNLESAKQYCNTVLQLEKNNDTATLMMADLMFRKTDLESSMFHFQQLLERKPDYYPALARLIEAMRRLGKLDQAEQFLKKAADLLPRSGVNGGYFYCKGLHEWYTGNPAGAMKSFNKARYDPDWGLISTYHMIEICINPDNETIGGETFDNGGVIAGDSAKVHYHEGAIQTAERLLNELRPKMCNDSDFRLMSNFVLLAKKSKVDAEIALNEFLQFSSEERNKDHVGAILGIATAQMILKQVPRARNQLKRVMKAPWNFGDAEYLEKCWVLLADIYIQSGRYDVSTDLLKRVLQYNKSCTKAYEYMGYIMEKEQNYKDAAQYYENAWKQGSQNNPAIGNPVIGFESYLGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTX1</accession>
    <name>A0A9D4PTX1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTX1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7955780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="270" mass="28738" checksum="DFBB8FE8710883A6" modified="2023-05-03" version="1">MSTRVRAVRLVSTTEEVEQAPMPPAHETELVEVEVLPDEPCTSHQQSPSPPRFPSRFCFAKSDTSQCSVVANIYCQVPDTRQVAATGSGRQLPEKKDGTPAPATSESGASTLTKPSGGGGSKTEPKKAEKTWSFRLGPRTPVSFEVTLGVKKAPSTCQPSAISVRLVDVPPTGPVGSVLVPRRASLPAYVVRRRSSVPDYVAEQDEPPPPQPWVKCVEELARRLAESGGPCRINVVTRSASFSAAENVASVFIDVSGSLAGSEMSQPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUH3</accession>
    <name>A0A9D4PUH3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUH3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="248" mass="27782" checksum="1ABE28D028A892D3" modified="2023-05-03" version="1">MDVKYCPRSHLCRCHGDLLDGSGGTLGHRRTKGADRARSEILDDEPVPHEVNEVDTADCGSGHHQNEQPSVNALSSQQTAAQEEFSSFLDQVKSTLCNFFFFVTEEHSLPHAAAEKVFSELQLVLELVLKAYGREVSHAAKTSTTELQQLLGCSFMSNLFHDIRNKYQREQYVQAHFPFTPPEEQILDSTAKYHNVALPKLLTALCEIPDIAARLTIPKSTVNAEGRKARTAHTSVRGDGYHQIYFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUY5</accession>
    <name>A0A9D4PUY5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUY5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045289"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7956097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="272" mass="31335" checksum="2FE2D06A5C630362" modified="2023-05-03" version="1">MGRCCVPNCRGNYDNGPKVRLFSFPRDAKRRAEWQRAVRRSDVDVRLLKDPKVCERHFKSEHLRTTSTYTDCDGRTIEAPMKLTRLTPDAFPAIFPDCPSYISNSRTSREEPELKRKRTENELLQKAIHESQAAFEKEEKQYKVCNLGELISRVNERPNKKFWCTTACETCLIVAHIEPALQAPEMLVSVVVTEDLSVSVYFKCAPLVSDDVCIPDEVRDVRVLDNLLDSVERYCEKKARQQEDKVEPEGNHGWRFDKGDPLCSPAKHVFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUZ5</accession>
    <name>A0A9D4PUZ5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUZ5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="14182" checksum="A0744A8E042B0536" modified="2023-05-03" version="1">MGQICALYEELVTQPPCSIQPTPSRQQPMDVQLELDNLSRRRKPACELHQSAVEKIHDRLRGHLLVFTDGSPSLLRQLLFIWQPTTSLLQHPNSPWRSSVAPDQPYKRCCGQTEPASPWHCCTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVD0</accession>
    <name>A0A9D4PVD0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_010107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVD0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033487"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="259" mass="27208" checksum="B9FECF3499E11FB8" modified="2023-05-03" version="1">MRSGERGPGRTIVHCHTRLEQSPFDENANKEALAQAANAQAKALEGKLGVDGRELQPGTTSPKVGGFGFVATPSPAPGVNETPLLTWGEIEGTPFLLDGSDTPLPRNPGGPQFRIPEPRSRERLAHSLADGAARRSAARKNAALDRARSSLLSPRLSPSPKSPLARLGTMSPAARHLASAKLGISKGIDRALRASYTPKTTTPGTPVACGATPSPLVPSPASRKDACRREPYLSGSDSSSLTDNLLKLPVKRKGAADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVZ9</accession>
    <name>A0A9D4PVZ9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Na+/dicarboxylate na+/tricarboxylate and phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_011618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVZ9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036076"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053632"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7956668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="84577" checksum="6F21BC8C164AB1CF" modified="2023-05-03" version="1">MVSKFIARFNKYNTLLFDFSEKSPVLVLPITTCAKKSHCEAPQKRRIRVLLYLSVIYGANTGAITTITSAASNIVFKFVIEDLYAERAPVDYALWLFFALPATVISTTIVYFTILPVFFRCKRPNLDKESSSSAMGAIRRNYAALGPIRFHEVAVLLLFTLLVFLWLFRDPMFARGWATLFGSMKPKDATAVMIPVVLLFMLPARPCEGARSPGLVTWPVVQAKLQWSVILLIGSGFAVAEAMRVLPGILVKAITIFTTVAVTFVLGDPIFGMFSEADWLRPVVTANISVTASLQAPQILVGNVYLTGEGLVFGIMFISMFLSIWINNVAITAMMMPVINSLSHELLQERRRSLSRGNIDVEGIAALRERAEKAAAANGNIKLVPHDDVDEEESDVVIPIKPKKEYSQIDKATEHRVRVLLYLSVLYGANIGTITTITSGASNVVFKFVIEDLYKERAPVDYALWMFFALPIALIGTALVFVIVVPFFFSCKSPNLGKESSNYAMAAIRRNYMALGPIRFHEVAVLLLFILLVFLWLFRDPMFAKGWATYFGVIKPKDATAVMIPVILLFMIPSKPQEGFRGPVLLTWKMVQAKLQWSVILLIGSGFAIAEAMRVSGLSEQLGLKLAELGHLSPGPLMICLSIICSFMSELISNCGTCTVLLPVFAVLAEDLNLNPLLFMIPTTIASNYAFMLPVGTPANAMVYEHGRLTIMEMVVPGLLAKLITMVVTVVVTYVLGDPIFGMFHEADWLSAITAGDANTTIVPVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PWH8</accession>
    <name>A0A9D4PWH8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PWH8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035573"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7955653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17831" checksum="46EDFF4EF72298E2" modified="2023-05-03" version="1">MLLLHDVQSAFVRLPKTAVQVALDSLGISGCLRIRLTLAGRPLLPVAADRPPKLLPEHGLSRHDRSTLFLLRTGSVWTAVKLHAKGRISSPSCSRCGDMETLDQLLCSCPALAQERAVVTATYRRYGLPSSTTSQLVHPVCPHIPAFHSLFEFVNSNRLLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXK7</accession>
    <name>A0A9D4PXK7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXK7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="132" mass="14427" checksum="330CA0D1634D7AD8" modified="2023-05-03" version="1">MPGDSRLKPSTQRAFGSRKKRAWNKKAPATSAPSAAELESRPDPLDLPGTSTDDTVGPSSTSETLRVDAAYYSTAEQAQRVERSAQTKTVLSGKSATQRKFDLLGVSGCKIVVTPLRTNHSEDNKWHKRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYE0</accession>
    <name>A0A9D4PYE0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYE0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="69356" checksum="9437830327FF2095" modified="2023-05-03" version="1">MEHLSAFTTISDEHGTPSSTANADARPSVTAQTPEVNTARQAADPAVSNFSSQQREVDTPPGERMEEDTTLCDNTDNDAGGCWKTVQRRRRDRHMHAEAQPPEDTSGIPDAPQPTTHKPSRNQNPPPLPLHDEKIILRPHGGLCLDSWTRPELANALWSAAGLTTEDRQNIIFRLRPQQNLAVISTPQSHVADALYKVRELRLGQRVYPITTYFAAPDNSCKGIVPGLVPGTLSSTLVDELLTPGTQILQARMMGQTNVALVTFEGLKVPRYVRFYGAELRCYPHRPRQLVCKICHRLGHWADHCPTPHVVICATCGIDNPAPSHPCTPHCRSCDGSHPTSDPNCPLRARQTPNKAWVRKALKKEQRELQPPSASTTSKDVATTEHSQVPTQGILRARSKSRSRSRRKSKTRSKSRSRSRGTSMRPPEKCPPDPPSPPSQQPYKKALLTNASAKVAQAPTETQRISAQKTATQAPREVSRAADLPQLAIAHTSLSTPSAHTTSSSTPDPLVEIARLRRDMEARCERLQKQMDTLVADMGTSMQAALDRIERQMEDLSIGITERVELCIERTLARNNNMQTPEPSSYSATLPPDHISRPQHSNVGNSNGGNRRAHPYTRPSASSRDDDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYG8</accession>
    <name>A0A9D4PYG8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_005193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056464"/>
    <dbReference type="OMA" id="CHETTEE"/>
    <dbReference type="OrthoDB" id="9978265at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF109">
        <property type="entry name" value="FI07618P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7961188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="399" mass="43506" checksum="47AF2C97BCB7E2B5" modified="2023-05-03" version="1">MGSQQFCLKWKSHYSNLLSALDQLLFSESLTDVTLACEGFSLKAHKAMLSACSPFFQTLFAENSHQHPIVILKDFKFSELRAIVDFMYHGEVNVSREQLSSLLRAAEALQVKGLTDLTSDTPELAEQLPSLTSSDVRASNVDSATVASPSKRPLKSPPSSKRKRVRPRHVTPREQESQVSSNDEAEEENSSDGEFLPKRTSEAVALQRTTRSSKSTSSCSVLETLLSTKELSGNCEQKHRLHTCHETTEEDKDFETSRLLEQALAKGDESSSSAVDSNCHQKMFPASSQLSLLATAKMLESGSGKPETEEDASALLATLAASGESSNSGNSSGQGTPHSLFPARGGRNSGWTEEQMQRALSAVFAEGVPMTAAARRFGIPKTTLLYRLQNSLTRRSPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ72</accession>
    <name>A0A9D4PZ72_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ72"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17477" checksum="358CF613E3E92169" modified="2023-05-03" version="1">MPSRALATTAYHQSMPYAPPRPLTPPRVLPTSAPVASSSRSPPEYARRNLLRTLRLEPSGTMRNEEAWSPIPIKVAAHMQLKPLPRNMNPQRHPGRRKARADYYIRWYRNRDDVHYVDAAVGPLEGTATADAMTEDGRINISASIKTARPDVAEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0C9</accession>
    <name>A0A9D4Q0C9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_014651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0C9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044736"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7962149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16071" checksum="70F77D3E68A1AACD" modified="2023-05-03" version="1">MLFVETADILAMMARETLVQARLPSFHIPCAVEVLTLGTYSRLPTCIRDKIVPPDPITPAERKSTLQRLDQIIQYRLVSLTLMGDGAHIPWRLLDIDILVEDKETGGWERGTARDRDVADAHGNALGAGASSRGSGSFFQVNVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q272</accession>
    <name>A0A9D4Q272_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_019287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q272"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056455"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7963024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="326" mass="37520" checksum="916CDB57E2EE9695" modified="2023-05-03" version="1">MSKKTCWENGTWFYSQEYGKEYTFYDCGSLEYHRSMTIFSIVLHSLSVVVLVPAIIIFSVYKQLQVHRIALHKNFCVAMVLYDISVILVDSVFILDHVNEEKNIRVNENPNLCKVLYTLSRYFRLCQYAWMFCEGFYLHRLITSAFAEQKSLLVFYVIGWGCPAIFVAMSAALRALRTGHPCWMDNIEGYNWITLAPGLFCLFANFVFLCNIIRVLVTKLRSTHASEPSQFRKAVRAVLVLFPLFGMHFLMTVYRSPANCGAWEVYQYISKASDGLQGFFVAVIFCYFNGEVQGQITRSIELVKLESSLARAGDRRRSTRTQVLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2D0</accession>
    <name>A0A9D4Q2D0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2D0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048547"/>
    <dbReference type="OMA" id="NTQHRHE"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039346780" evidence="3">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7962755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17922" checksum="F827DAA9ADAA3E41" modified="2023-05-03" version="1">MNKLTVLLASSLCVVAVQAGHLGHGVLPTYVATQQLYYKPQPYAFGYEIKDAWGNTQHRHEVGDEYNTKRGSYGFTDAHGIYRRVEYVADGNGFRAIVKTNEPSTKTHHTAHALYHSNAPQHVVHQGQHQKEHLEVPIYVDAAPQHTVIVAPVGLGHHGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q2R5</accession>
    <name>A0A9D4Q2R5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q2R5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036105"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27237" checksum="563732BEE4F61E05" modified="2023-05-03" version="1">MEIAPNNDATPNPTVSDPAVATLSLPDRVLAVRIGTLVAERRAGIPTTPSHITNSKGRLLEANEQLNRKVDQLTSEPNRHAVNVHLRLAAATKKFRNIHPVHNEGRRKARAEAILGKIDSSSTALFFDAAKYWKKDAYVVKVVNAKASLVNAATVVTGFTHEAEELAIAVALQERRRDVTIFSDSRTVIRSFSSGFVSAAAASIVNKTTAEANEGEDPLTHIIWFPAHMGDISSSPTGNPNERAHQLAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q414</accession>
    <name>A0A9D4Q414_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_022305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q414"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053897"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7963637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42178" checksum="8DD3E706B87AA285" modified="2023-05-03" version="1">MALIHLKEMLLGLRASKTPAVLMSLGFQGAFDSVWHPQVLRFFQERHVSANLYHLLRTFLQQRSVVFRSNAGELVAYPSLQVRRGVAIQAYADDTFIVIPVESRERLGEVGSVVLRDVVRWTVEAKVTLSTEKTYCVLFSHGHRGMEKWRPPIRLNPNDKKLTYRDSLRILGIGGLLRPEQKVTLYPPSRTAWRSGGTSYAPIRSVLNVLGAFRTTRTTALQVLVRAPPITLELERANAEFRLLVTCMPIQYENLSLRPEHVLPTLDVWLDHPAARYAFQFRLLTRDEARRMARMPGLHLYTDGSYTDRLAGTAFVILGPNDRIGSVGRYWVDHATNAYCTEVIAVVEVLRHVKNKGSASIVRLYTDCLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q432</accession>
    <name>A0A9D4Q432_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PUL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_000141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q432"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040243"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUL" evidence="1">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7967578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22145" checksum="831D75BA980737B7" modified="2023-05-03" version="1">MPVDGQFFPQTSFVRFDAANTQGMLTKMREFNSQVPPADRVDDEDLVQLMELASASGAPSDCQVATLERLVFPALDLLRLAFRNPLVSSRMHRSSGAKLCDRLLSLLVPTSLNTSVNQMLVLRCLSNMFLTPSGEVLVLQERRKIMTILHQHATLEGSKNTQIAMATFLLNFAVAHQNEGAQCNPNAVEQMSEILTKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q625</accession>
    <name>A0A9D4Q625_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_010657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043334"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="1592"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="2149"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="745"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7968690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="2281" mass="248994" checksum="130EA82E91C47085" modified="2023-05-03" version="1">MDSHDHELSLTTGLQSKTPSPPPRLLTRSVATPQAAPRWLNQTAPLETASIDDAGEQPSATSRDRPRHAEPGAVGRRGSSPLPGQRTRSAAASGQSKASPGLMQAAMRDSTFVAVEAMSRASRRQSRTGPPVPVRAKLPYKGVPKKELDIVIELPKNIVRPVRHLGRTKGTVQDASMSNLPPLPAARMPQAATETTMTVGELSCATNAAAGGVSAIQLSGESSALRSISTTVGTIVSRLFTRGPGRHQATSMSTLETASTTRGRNPREIYVDIALRPPPESTASVGPITAPTALRDSDGALLNTGEITSGAPKVCSLKHVVTLKSPRKRPWKGMKGEERGNMKRPPEWVAAERLMEAPWGSPFWQQQPAEYTATRGPDSHESVAAPKASTKKEPRKDTPAARRRSSTSQVSSTMLPLEEDAFRGTKERVARRASCFADKERKKQPKPAMGAEKHDDVYFDKLPVKDARKYSVTLPQKSSLKRKQSADRIGEVVDEYTKRHLKADRDFRKEVVSPTSPPEGAGEVAVEKDKKDAKEEALRRESVAPASLVSPISLTPTETVKEVPTKKAKKKGKERRSSTMKTSALSSSATEEISTKETTKARKGKKTSIKQSAASAFLPEGAGKVTAEKKKNDKEEALRRESVAPPSPVSPASPTSPEATKEVPTKEAKKTEKGKKPSMMKTSALSSSATEEVSTKETKTRKGKKKTSKKQNAAPTSLEAAKEASGQTEEDKDRRDMVSGNLSRTDARPVDTAEKHTISEGQLHEEGAKHEMPTGKERSPEEKPTDAAMKEKVAQVISGDQREITQIALTSDLPQEGKRKDNKKPTEVSATSKNVELEKLAETGVSQLEGHVKASKNGKKAKPTHYTTEGDKTMEHLEEGKTDGPHSPQKSSLANDAEDVQGREKIPKKGGLKKTKGQTAEGGKAIEDLAEGTALASEGVLQSCMKKADIAAALTPQGAEVDNDHYEEEEAKASRWEMMRRKDSMAVHRIVQKKHKGRGPVAEGGPAVLQLGNRVRLPVQKAEVEQPTDAGHALEAGRVPDTGLSPISSGRPRQKGRRKVRDRGPGGVPGVMPMGPMPPMGMMDMRGRMPRRRRRWRGRERKGPYAVGDSASKGIDPDKIKFSRIKMSPEVPQAEVPLVRHSPIFDAGSPTSSPKGGSPASSMISHATPEIKREKEKSQPRDGPAVVPPNQGDAPGMSSGDLSPIADKVAPKTSGTLSPKRKRSRKKRKGVLKTPRTHLKGKGGAMTVQELLKEIKQRKLAQGTDAEKGPKAGKSEHKSSGKKKIKAKKKARERVKKKKVEKKTADTQTSFLFTEPETPAVMLESGDRGFCDFRFTVGLNRVVRGALSHNESIGQQAQRESPHAATRATNVDDELELLDSGTEAQLTVASAKPDASSRHKATLPAHLTESVYLRNEIGGDEPRDEGKKGESAVSQQKVPHPLPPPDSTTFTVDSVLPESPLKEASTAAEASPVAHMAVSLTDFLTKTAHETRSLEERVKTESPTEVSTVAETTTLSSEILTATAAESTSPEKAVSPASMGNMNRNKEKSPGGSPRSSRPEATRGESVHYCDTAFCSQEARYVESLVTSNQRPCVSFYEHVCDKWLSQQPKRPTGSEPPLSRDSILQSSLARQLLSLVQDSIEPDLQTAAKLYSSCAVGRPSNLTSEDKTALEIMFESWVIRSWPRTDHKNLSNLSVWRFAAELARDLDLATLFMVTVGVDPNDVGATILELSSPRSLFSDSDSAFEHEAKVYRTAVHEIIASLNATTSIDVDDFTNRLVKVSGVLRSATLQSEAEEDFAVLTLRDLDQGVRHFTETLLANVVDSVQSTSMKVTAKSPKYVRADLPNALLSVPPLDALNYMGFLVLVRVAPFLPEHLQALRTLFGKSVVGHTVADVTDTARLCLWLVDHSLPGCFSKASHKWLQQEGHQDGLKQWLNHLEFVFLAHVPDFAWMSNLSALLVRYRFKRRPVTHFGGGSLQDEDSCAPEVPSNATVDHPLRFYLDVSTHRPERKLRGLLSNSTVLRRQGRVDAASELRTEVTFDHALHRVHVPAALFNLSVPTNSSFFVFQLARVAVRFYRGLVQALYENPFEREVPLRFTDESRRRLSDLASCFVDDAQRSPPDVRGLWSPPRSQRRWSSVGKPLLDQVSALLLALRAFDEFLHVRRIWKADDRLADLPATMAQKLFFVYLALDNCEPTRTVEGGGIPALLRVNLPLRHVPQFAEAFNCSPADHMALSPGMWCNVFRSGAVQLVRTAERRRRGTTAMTHFGPLDGPYDGRPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q695</accession>
    <name>A0A9D4Q695_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q695"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="72" mass="7658" checksum="51EE6B5831E3C09E" modified="2023-05-03" version="1">MATAGIAFGLASGRSVAVAAAPTGPVVFARVAGAIRELRKRRLLARLTQPTQQHGFAFLPDRCWRERGAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6J0</accession>
    <name>A0A9D4Q6J0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6J0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7968606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15472" checksum="910EABAC05D65A9D" modified="2023-05-03" version="1">MPRQRSMLLPVPDWSWTTEFSRDLIGKTCTRGELEPEPVALYTPFTLESADVVESTRTGSRESLRKSGIESRVRSGDIRPLASVGVVAAVGVVTGLASTVNGSVSSVMTTAGGGSCCVFGFDMARNAAARFERELSSPKPILFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q6U1</accession>
    <name>A0A9D4Q6U1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_014707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q6U1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027096"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045911"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7969111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="790" mass="84901" checksum="07C6355993E108BA" modified="2023-05-03" version="1">MAEQHPGQAERFDWDAQVQGLVLGSFFYGYILTVLPGGVLAEQFGPKWLIGLGVVITSLLSMVLPAAAHAHYIIVVVIRILQGLAEGLVFPAMHTMIALWTPITSRSRVVSIVQSGSDVGAVVAMMASGVLAESTFLGGWPSIFYVFGFAGIVWFVAWSLLAFDTPSQHPRISSEELEFIIANQGNEQAQLKRKVPWLKVLLSIPVWSSVLSHFGFNWIHYIFLSEMPTYLTSVLHYSLGANGMLSSVPYVLGAFLCCVASVASDFLRKRGSMSITNNRKLFNTLGGMVPGLFLLLVPLAGCNGFWNMVLLAVAGGFHGMGHSGFMAAFVDLAPDFAGTLLGISNVIASIPGFAIPAMLGELLKEQRSISTTSSRNAQFCNSAEEAIKEIKSGSKLLVGGFGLCGIPENLISALSKTGVKDLVVVSNNAGVDGFGLGILLNTRQGTLAERLRAGGAGIPAFFTPTAYGTLIHKGGAPIRYDSNGNVAIKSELRKHQVFNGKNYIMEEAITGDFALVKAWKADKAGNIFKCCSSRFFRKTASNFNPVMCKAAKYTIAEVEEIVEIGALPPDHIHIPSIYVDAVYKGKSFEKRIEKRKLREKAGAGAGAKDDLRSRIIRRAALEFQDGMYVNLGIGIPVLASNYIPKGVHVVLHSENGILGVGPYPTEEEVDPDLINAGKETVTALPGASYFGSDESFAMIRGGHIDLTMLGAMEVSQYGDLANWMIPGKMVKGMGGAMDLVSSKAAGTRIVVTMEHSAKGNKPKIKKECTLPLTGERCVSPNLKPMQQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q778</accession>
    <name>A0A9D4Q778_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_015053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q778"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046473"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7969145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="613" mass="67696" checksum="C9B9635A33485BBE" modified="2023-05-03" version="1">MECVVEGHTISAEEWSDGSWQPSPGFRAQEKRRLELRQATPHQNAAQQATATRNDMKPRPPPQRKRGPLPRMPADTIHIVGRPKTPVDLTKLPPWQLYEALLKAASLPDQPPASRDKLRVHPTNNTFTISVPDSVRAQAYLRITSLQVGDRTIEFHVYAPPPDDAFRGIMFNAYDSFTDDEILKDLQESNPSMPVVGGRRMGRSNHVLVTMLGDCLPRWILYHGVYIRLYPFYPRVEACFNCRKVGHRTDVCPHPKRNRCSRCGQDHPPTPQGTQPTCLARCIVCNGGHATNSSNCKYRFIKKPIPSDNAPKQAHNQEPPQQQPSILRNSRSPSQERSLPPPGQPQQQEQTSRSRSHTRRRYRSRSRTQSRSRSRSTSRFNSSSSPLPCSPNSSQGSSPSSSTPGPKKLAWAQGPPESLKASPTSSPDAQVRELVRENSSLKAQLSSQQSQISKLMSQIGNLTQYIQSLEAKLDRTIAQPPVTAPQPMEATSPPSQPQSQPAGKRKANTSTASLHAEIDIAAAVSKAVSAALTTLDAKFEARFNTLQQAIADTNSSLNALKSYTEATNTSLNTLKNYTEATTAEINARLERRQRSTTFGQPATLQAGPKPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7L3</accession>
    <name>A0A9D4Q7L3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_016404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7L3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058418"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="731" mass="79710" checksum="1C528A3B571E13F1" modified="2023-05-03" version="1">MYLPGGVTLPKKSAPVGLQLWHQRAIMALGLDHLCLENMDMFLKISSRHITDGQGVVMGTLLVTPNNVMFIPNVSDALVMEHGSECYEVTAPMDMVVAAALYNDITHMRLRDTVDPASGVQLEEPYRPADYQPPPKDQASASQNTSELAKPSQECATEVPPVPSTQDAIEKPCSALSHTVETLEEPAPGQMAGTEGKVIITSPPKTPEEGTASSCQCKPPKEVQDTVIADTVVKSKNLEQVLEQDIKQNVHLKSGTQKPEAVVESTEQSKAKLESKDKFTLEKPLHSGPQKEVCMVQAKENSGLEATSTLSGEAEPDVGRGASKPLSVDAAPAPQAHEKTGKLEAAAVETGTGESNNMVPRGTQLEVELSSGTVHVVKDDRAGDKLVTKDITALTNVQDKLLTDTATPQNKILGTEESAAAKKKEKKTAEEYLFKPIDKASESPPTLRREPDNGSRREKAFTPPPPSSGGKSLPEPARWSRMLSPTLKLDSSSDVPAPEPRSAASTESITLRMREWASAEGGISSDRSQESAHERVLKRLSNPMESISSYTHSISKMIVSSPKSLADFVRGADDPPSTPPPQLPAQQPAADEKRPSSRADNANVWLKNMVEEKPELFAAFEKLVPRLAQSSEATLLYLCLRMGRPLHKKVQCSATTSSKRRIRPQYWFGIPRNRADELYYFLEKWAPSIYGDVHRVDMASRGFEPLPEPADRGGDREAHCLRPHCGDDQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q826</accession>
    <name>A0A9D4Q826_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q826"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045875"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7969950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41864" checksum="896B4095820A7EB8" modified="2023-05-03" version="1">MVKRTGKTTGASDLVQCGECTRWCYLDETAFTSLADAEEVSFECKLCEKVKAAVQRMEACIEELKGELKVEREQRIELQAELGEARERGEATASLVEQMEANLRKERERRAELEERVKALMALDSGPKQCEAKGKDNTESQAETGKKGDLGAAVAHVGTGDSRRKSYSDVARQSSGGAKQGAPAAGWLSRVGGTQERLDRRRVLVVGDSSVARVEQGVLTTVKADRRVKVEAQSGKCMTDALAKAQELVGDSMEGENLVIIHAGLNDALKGKSQNLQRQLEDGVHKLREASEGVHVTICTIPEVWGQSGGMERRVIEGNCVIRGMSRQLGYSVMEVNKDVYEPGFRPFAQDGIHYSGATGRRVGNRMGRQATAFLGGPSALRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8G3</accession>
    <name>A0A9D4Q8G3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8G3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60339" checksum="FFFB42451FAAD7E4" modified="2023-05-03" version="1">MTAAAAMDTTPPALTNHDETSPSNEDGSAWVLVQKKRRTQADLLESTKTSELQGKTTQRKPTTSWPPPLPLHDYKAILRPLGGLRLDQWSRPTLTRAIGVAASLPPAEVDRLVFRLRLEQNLAVISTPHEHIALNLYSVQHLRLGEHTYPVSIYIAAPDNSCKGIIYGVDPGTSPSELMDHLITPGHTVLQERMMGKTSTALITFEGLQVPHYIRYYGAEYRCYVHRPRKQVCTVCLRLGHRSDNCPTPNCVTCKTCGVDNPTPGHSCTPKCRSCGGDHPTTDTSCPARVRPPLHKERVRKALQQEQQQRDVEHHSTPRHRLRDIQIPVPVQAEVAEQGPLSYPLQDGVSNATCKAGDHFGSHRTTGDEPAFPPVERLQPARQESRSRAAPGGTSGGKLGEGASSALTFLRYPSQTLASAPQTTQNPDPNALHQLRAEMEVKLRALDARLRREIEAACTTIRQEFRDMLNQAVSTLKDTLNDTVATLLNLNSSSISTLSTDIQQQTERNMQQMRQEFAPALTLAPITKRSHPYTRPSPLRSEDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QD70</accession>
    <name>A0A9D4QD70_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QD70"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056395"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF1">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="714" mass="82219" checksum="93EEA2A14365AF50" modified="2023-05-03" version="1">MVRAYLSNGFRAFCNRDDVALAVIAVCLVATAYLGVLTPGSTASKKPKLTPVQDDHRPRSFYDTDGHTGYSYDIIPDIVHLVRYNQTEVQLIDLVCFRSIYINHRPEKIYVHCSPCGFTGNYTRLLEGINFAFIKTVFPNEIFNISIKEPHHSTDVVRLRALLRYGGIYVDHDVFVVQSLRRYLRYEASISCPPGGTFGNMLMMFHKNSRFLRLYYNSYNTFNDSIWYYNAGDVPTVALVQPHTHLVNRVYYGLETQQDMLFVLFEPHAYPYWRDVFAVHTSVVHRFDLPYDALHNAEITETNVRNLNNAFGEMARSVLFGTSDFVSPDYPVLSVAELSARKDRGEDLTRRRPGHERTFFEPFLNQVDDVTLAVIAVCLVATAYLGVLTPGNTASKKPELTPVQDDHRPRSFYDTDGHTGYSYDIIPDIVHLVRYNQTEVQLIDVLCFRSIYINHRPEKIYVHCSPCGFTGNYTRLLEGINFTFINTVFPQEIFNISIKVPHHSTDVVRLRALLRYGGIYVDHDVFVVQSLRRYLRYEASISCPPGGVFGNMLMMFHKNSRFLRLYYNSYNTLNDSIWYYNAGDVPTVALAEPHTHLVNRVYYGLETQVDMLRVLYEPHAYPYWRNAFAVHTSIFHRVVLHNEEFTETNVRDLDNAFGEMARSVLFGTSDFVSPQTPVLSVAELSARKDRGEDLTRRRPGHERTFLEPLFLNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDP1</accession>
    <name>A0A9D4QDP1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDP1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047515"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="25690" checksum="3E0ADBE3E6095581" modified="2023-05-03" version="1">MPASVRHRRNQPKKDVVFGPDNYATSVDYDVSLLLYAHPDGCPYESLYFKQALEERGLLPHVDYVVQKGKPTNVFALVLKTVEDKRIVADVPALRVKGRYCAVVDPCLKETTIKVHWVPFNVSDETLREVFEEYGVVKEVIREKCIEKGFEDTESTTRHISICLENNYLKHRIPHLWNVGEARVNIFIPGRQPKCSRCLKMHHGRYHSQEKRCPTCGTSKYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDS2</accession>
    <name>A0A9D4QDS2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDS2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046412"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="289" mass="30519" checksum="EE3BAA23FC0F20C5" modified="2023-05-03" version="1">MGDYYDEIRQTQLRELALLKNDRKNGAAAAASLESSPSSSQASLPAAPPATASPPCGNELVAVNSGNNCTPTWHISQASVLQEASSSCRSSPPTPPMHPALRPGVPGLVLTADGLSQLPPHLQVSSAGLTRGVVAPPTTAAAVSAAAAKAAYLLHGSRVLPVRLSRKGALRAAALTLGRAAAVGALRHGAAVELISADCADEFLYGDEYPDNNFDGNVYEQAFTTIEEQGFPRQNAEDMQNNGYATDADFAEWAEPPLRTHCHLPARLKPSQAMTRRLYRPYGPLPSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEA9</accession>
    <name>A0A9D4QEA9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEA9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026380"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="18355" checksum="3C71CCC644905F43" modified="2023-05-03" version="1">MAKKTSESSLDRSDLVDFVIDARTPEETRAIYNSWAPNYEEDMTLQKYKAPSIMAHFISQELHIKKDAVILDVGSGTGLLAVQLKNLGYSDMDALDYSDEMMSEAKKKNIYKSHFLEKVYKNNKLTLKDGQYDVVALCGCLMPGHIMPDALPEVARLLKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEP5</accession>
    <name>A0A9D4QEP5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_016116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEP5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048249"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10542">
        <property type="entry name" value="SET_SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7976551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43823" checksum="DF77F30CDA76AEF1" modified="2023-05-03" version="1">MSSPSKPGSRRCVAPAPLCNGIVSGRITQVPNGDIANDVDVQDGSEIFGKFPRLVLRRLTNEEILAATGYRQSAPLQDNGFIRKQDIIDMRKQVLHLSAHRSGQMSRIVKAFGSWESFVSTVEERRSLARTLHDWERYIQVASWHPLLRVENYVDQEAPPAGFVYIKDFLPGPGVVFPDDPKMGCSCVDCYQDRKGCCPAFNDLKFAYTANGTLSAPFGSPIFECNRLCSCDMNCPNRVVQRGCKIPLTIFRTTNGRGWGVRTEQRISKGTFVMEYLGQVITDEEAEKRGKWYDEQGTTYLFDLDYLPEDSQCLTENSQNQGTVYTVDAGTYGNIAHFVNHSCEPNMAVCMVWINNLDLRMPRLAFFTNRDICTHEELTVDYKMTSPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF55</accession>
    <name>A0A9D4QF55_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_018035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028668"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7976680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="390" mass="43434" checksum="3E319513FC428CCA" modified="2023-05-03" version="1">MASWEYTLTGFGDFLEQRRLAFTQPMPASRVCSICGRVPSDTALLPCGHVLCVQCQREVFDGMECPFDGCAFTEGQLVRLRFELTDLEQLRVVCIVGGRKCAAFSGKLSELRDHMRQCRSVDVQCAKCHRSIASEAAVEHYRQCYTESAPRRLSSDLRVRRAVEEVRRIQEDLQVLRQQSLGEHVTGDDGFVNGANGLLEKLASLDCALSAVQEMEANVDRGGSPLSFRKAPGPFRAASKPGLFITTCKLTDMCAAHDSLEGNIIARTVSSESCTLAGYTFRVDCRFSLSGNGETEEVNVSFILYLCAGDWDEHVEWPFTKKAAIIIAHPTDESKDIRLNMPCMKGCNVTKKPSSNRTNWGPRTENKSWKDIELQGFLVNDALYVNVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QF77</accession>
    <name>A0A9D4QF77_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_003933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QF77"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047771"/>
    <dbReference type="OMA" id="GEMFCGH"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12109">
        <property type="entry name" value="Hr_FBXL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045808">
        <property type="entry name" value="Hr_FBXL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF19">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7975638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="608" mass="68181" checksum="D864F5EAC8449F76" modified="2023-05-03" version="1">MAPFPEEVDVFSVPHSRMKRLVEVYNEKLGCTDFADYGALESLLHELYQTFREFRCHEQIENQLIMTKLKKKLKALSIHDSAVCNCHSDNRLSDMLALVRDGYSCTNKSATERVNYGLKLQHALIEFTEKFLPHMKEEEEVFQPMLIQYFGYEELKLLKERVIREHTKWQQQCSQEKCHIELENVDQKADSDEDDTDELPSWADMPQEILFDIFSRLNARDLSICGGVCKSWYGVSREPALWKELMPVHWALGLWDHVPLWPDPYYESKKGKGHADEDADFDESSGSSSDEDSPSSPSADTLRKEATVLNCLVKYLLPVVGNGVRKVVLATSHALNSRLLRSILKLCPKVCHLDISYTGIGDTSFKGLEEHGACSQLEHVDLSGCSMLTDVGLSRLAQCLLQRRRASTNVCPASLWQDALTWHCDRYNIGSSPSSNLSFNSLDAWDTPAEAVSQSTSVVVHGRSRFCDGCPFRSRCNGIVNVLSELDLSDSDGAASLNLSTKQDPTQEGSSSLGGLRHLNLSGCFNIADSGLLYLANWDLLSHLEYLDVSGCFQLTGEGLRELMLGTPRLQPTNLFYCDYVDNGPFQDTANGCQNLQCFSRACCQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFB4</accession>
    <name>A0A9D4QFB4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_004586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFB4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034840"/>
    <dbReference type="OMA" id="NIWPHEA"/>
    <dbReference type="OrthoDB" id="6136301at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7975698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="457" mass="52333" checksum="A640B0AD7AD73A61" modified="2023-05-03" version="1">MSASEKKDVVSSDPPANGSNCNCEPPKAVRPSVRTAFKQRKYTILDGLCVLCSVGSFLFDTGSDIWVAYRHYNDGSYWYFGLTVAFIMVPATIMMGFSFRWYLLDLKQHGKHPSKLQWFVRTAFHLLQLGQVVRYVDALIYGLKSARSKSEQREFYRRSAEEDVDASMLRLFECFMEATPQLILQICILARDYPHQEEDFWTMVAQNVSIVTSLVSVAWSLASYNKSLRLVIEDKANMRWRGAAVYFLWRLFVIVPRVLALGLFASLFPLYMFLVCGLRWLIMSAWIISMKTQFYENRVEELVYNLVLGVVFIFCYLNPVDTPTRFRMSAFYVGTFLENTILLGVFYAYSPSDIWYKVPAVLGGTLCFFLGITFMVIYYLLLHPTGSIPLVLRRNQCLPLPRAQMREEMLKTGALEKDMAGHLESLTTQSPPSEDDCSCSCETDSSAARDSRNRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QFB8</accession>
    <name>A0A9D4QFB8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QFB8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048298"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7981852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="492" mass="54388" checksum="434056DA931DA60C" modified="2023-05-03" version="1">MPTDAALKRARRRKLKAKAKLTGSTNSGPSNLPSHMKADPPGLSTRLEMQQKSEEDDPTKAGAASNRCSNDGSVPTAENAASERRAAESIPHSTKPMDENELEDIAKNSTSDASSFNFEVNLITSEQAESDALTDSDAADIARLLRKALKKNGPSLEEDLLSALSPPQVQYVIHAYGTLTAFMDHRPEFKLAREGQYIFVYYEDVDCEECGCSGQSDTQDEPNSGRYSSGANDGGSQHSDDGEREREQCSSSSSSCYETAAEEQYEEDEKHELKDASCQVPLSSCHSRGLQTEQETSDADAQTKELDTSRFVELQSTLQSRDAYVTQLKERLEDVRQNQVSEVQQLRLKTEQLLTSPQAPTPQHVVSLRNRTAKREKQPVDNRAHEEVHPPLPRPPLRQRNLPPRLRPESKLTTHPVETKPQPVTHADKLYSSETPLPAQAAHELPGWKKSANACTDVVSYGVMPGENNEEQHREANISNCPYGKEETAGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QH18</accession>
    <name>A0A9D4QH18_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHOD1 N-terminal GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QH18"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041387">
        <property type="entry name" value="FHOD1_GBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHOD1 N-terminal GTPase-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="69" mass="7707" checksum="77EE55C76CF830BB" modified="2023-05-03" version="1">MATLTCRVQYLNDIDPFSASTNFPEPARPPTYVFNVNIPLINQIAGVHRLLKAPHKVLCTHHEQALALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QIB0</accession>
    <name>A0A9D4QIB0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_002680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QIB0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040640"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041421"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7982031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28390" checksum="340DCDBECBF2F267" modified="2023-05-03" version="1">MVRSSILWDPYCLAYLNWEDIEALILREKEPPRRRVYASRGGLLNLDSMSSQCFRRQFPFEKADIPVLVRALKMPQYITSAQGVRVTATEALCICLRRLAYPNRLCDQQECFGRHYPVVSSVSNKVLYHIEKNFGCLLSNMTIHPWLKHSDLEAMSEDSQLYEKLEALALDKEFVIYGDPAYPLRPLLIKPYGGAALTASQQEFNSSMTLLLSLDSELFDSQTHHLKRVLLLFQGPLVCPPLLDAKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QJ57</accession>
    <name>A0A9D4QJ57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_007352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QJ57"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047461"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7982825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="226" mass="24443" checksum="7FE16922BFFE20BC" modified="2023-05-03" version="1">MAPINVLVDAPKQLPQIPQQSSARDRLSPSEKVLPDKRKNVAASLLHPPGDVPSVPKTSSLDLPLKAPGVPEGPPPELLDNTESEEVGIPVINVENAAEENDFSVSPQSWKIFSDDGPHCPPSGKEGMFVVIPEATYLDKARTALAKNFIPATGKYSKIKSSALALLEDLNLSALVRYLEGDNPGGCQAFSLDVEDLFYAIPQPELMVAVKECITEYNDEQKFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNE4</accession>
    <name>A0A9D4SNE4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_004949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNE4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037568"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="173"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="374"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7935250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="531" mass="59828" checksum="9FA8F724E8ED83A9" modified="2023-05-03" version="1">MYVSNLIWQEHLLQGIPNPLVTLGGRKGVINYLRAQLPGSNLCCSARRGFFQYPLPPAIGDSYVFSYERWRNKREVSYASKSKVGRNLRPPGWNRVVLPAFEKNVYREHVVTALRSASEVAGYRKGNEITVAGRAVPKPILSFDETDFPDCITKVLRAQGHGSSPTSVQAQCWPVVLSGRDLLAVAATSSENRFLAYVIPAVLHVRSQEPMPHGDGPIVLVLASTRELARQVQHTFSRFDKDLGIRTACLVPGEPKEAQLKRLGEGCEVWVATPSRLVGLMEECKVNIRRCTFLVLEQADRMLAMGLEKQLRLIVANVRSDRQTLTWLTSSTREASLLADEFMEDYVTVTFGETSQQSQNRRAEHIVYVCDEKDKDDRLITLFEDILDNKRDKAVVFVETKGKVDDLVTSLRLRDWPAVGIHGRKTEQQREWALNALRFGRMLVLVATDMAGHGVDVEDARLVVNYDYPRSLDDYARRVKHAVRDDGKGRAYTFLTPTESRNAKELVRILRDAGQEVPPDLLKVAKKTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNF3</accession>
    <name>A0A9D4SNF3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_010544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036781"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="593"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="917" mass="102693" checksum="5E3BE48FA7FFDDBA" modified="2023-05-03" version="1">MSLSYCTLEDVYIKMVTGANAKDKLDIGDGAFRLASEKDDADKKKRDLQAVKQLCAARSSKAGSLSVLWTLLRKRALLWGRVWWTVPFSFGIPVACMLLLVLSERYLLPRREPNGGAFIYKPERIFGVSYGFIESDNASKNFGDNVLLPLLSEHSVQAFAPTSKFVERELLFWAETDLYTYLYEYKFGISVFENRGLYVWFNGQCPPSAVIGVNLLHTALLRNLTGSKNSSMTLVNWPPVSSDLVAKVEFEGLYGKLALKDGRETLGHETELFPTRNFLTRVLYAFFLSLAMSFHAASHVFVPMVESASGLRHMQIMTGMTGIMYWTGHFVFDMFMAVCNSIVLVFILFITHSDIAPPYHLAILALFIANSFASLPLAYLFSKLFSEPSLAFSCMVLGLFLAGIVGSLGVEILDVLVQEDPSAAATAVLFVWGYVCRWFPTYTLVRGVVKVVLLSRLNAICLAGGELLAEACSDVQYSWDDRISGCCEALWHNTTATLVQPLQPFPETGFYEFLSMMAQGMLYIAVLALVDSRLLFSLRWYLARRLQGSEQPVESAEQRGPRLVAVSMDADVEHEVNLVNKVCHTRAFDNIAIAVRSLEKIVGFVKPVKLVDGVSFLLKKGECLSVVGINGSGKTTLLETLVGIRVPTDGDAYTSALTLVTDIRGWQRGIGYAPDGISKETMPALTVGEILDTVARLRGVVQRRQACQLRASKTLYSRGELKMLLIACAAIGVPPVMLADEPYTDVEPLYRNDIIHMLQLLKDSQIEMLCDRVAFLESGKIEAMGDMQHMDRKYGGCYHVIIRLPLEKRNSVSLINRIYFAMMEFHQCEFMYNYKGTLKFNVGKTYTTWGELFSLLVSTKEKEKLPEFSVSDIPPEEIFVGLSRRQLFFSFRRPRTNLSRMPSHVDSPPAAFEEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNG9</accession>
    <name>A0A9D4SNG9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_002560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNG9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044268"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7934984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="149" mass="17337" checksum="792A5A45D06882BC" modified="2023-05-03" version="1">MRPQDTGHAEGIGEASNQQDGSKADEEPRNKCRFCEETFRCAEDVRKHDSENIANGKHLCRVCGLLFKFPSVFQKHYRRHTGEKPHTCKVCQRKFAESWYLERHQKSHGGEKPFLCDRCGALYTRKESLTKHVNQRHPRDRERDSGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNJ5</accession>
    <name>A0A9D4SNJ5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_015182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNJ5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057723"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7935927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="393" mass="43883" checksum="FCEFE44251CBA56A" modified="2023-05-03" version="1">MLGAFVETRTASRTDSALPGNPSSSLEQLNNPPALPFSLKPVLDLDALEQVVKQEKDAVLISCKLEVAEVGRQDGLGNENADEPPSAHCVADPASGADLVTNESPGHLSKEDIPNNAELQPCTPSVVHAKAVQRKRSIYGDHVPNDAKATRRSERFHESSPEKSESSATPESITESDYGPGTSRPKRIRAETRHPAQCDPSDNGTPSQNAPKGATCQKSAQGGGTTKTRQCPSCSKVLSRKYNLNRHRQLVHEGLRPFKCPHCAMSFGEKASLRSHIRRVHTGERPTFFQYSGLQKHLMWHITFLCFACDLCSIEFVLKEHLKRHVRTHTGARSFACPHCPRRLSTLQTLKRHRLTHVDDWQHQCEVCDRRFHELRTLRDHARSRHPTEICFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNR2</accession>
    <name>A0A9D4SNR2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_015527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNR2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044543"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056527"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF334">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038854854" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7935956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="441" mass="48869" checksum="1ECAE84DE0C4F974" modified="2023-05-03" version="1">MRTVPATTAILLATLGITVTGPRRWGATASSSPSIPLVHHHQSHATPDDHCRQPGPLGLLAGRLQEWQLSASSTRQPECQLRYARVLELASRGAWCPAKDADTEWIQVDLGADAKITGLLTQGRGDGREWVSSFAVSYSMDAYHWKHCLDLSYLDPPVHARFLRLHVLRWHGRPSLRFEPLGCQGTFYVGTVRRSIPHVTAKCNEVISVPPVARLTASSWRPWHPQQGSCSPDEGQLFARGGGPGAGDPSDRCGHQGPRGCPAQALDHGVPALLLQRQPPMAALQGRQPPGSQGRSAFSSATLAAARRAQPLQVFGGNMDRDTERRHYLNQPFVARFVRFQPTSWKRRIALRAAVIGKLYHEMSNLDKLTAYVVDRPRLEEIPNAYKCASVSRLHGALSRRRLHFECPDDMEGRYVYLKASGVHNRKGRLYAAVLCEVMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQI1</accession>
    <name>A0A9D4SQI1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 6B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase subunit VIb isoform 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQI1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035229"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7942849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="179" mass="20271" checksum="6D521E4A50FA21C9" modified="2023-05-03" version="1">MLDRSPKPWSSGSGVHFGYGRWRVRHPPPVTQPVIKRVQTLTQALGAQGFLKGSTLTPGVGVMVNSAPHFPVIDPDAARIILIEFPVCVQRIPDPSESSSMSSQKVELHTVPFDPRFPNTNQTRNCWQNYVDFHRCEKVKGEGYEPCKYFQRIYKALCPNAWIEKWDEQIANDCFAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRC2</accession>
    <name>A0A9D4SRC2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_018180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRC2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050602"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7944305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="174" mass="20054" checksum="82EE06EADE94B24E" modified="2023-05-03" version="1">MAARRIAKSSVDWAAFAERVPSNQKQSFQALKSKSDGYLRRVLSLPENPPPIDFAMYRSRLANPALVEKFEKSYKAFSVPFPKEHLTPKIDAEEQAAKEEMAAFILESKDRIEEYKKELARFEAMIPALHMTMEDFADYFPHEKIDVDNPTYWPHDGSTDYDDSLDYADQGDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRZ6</accession>
    <name>A0A9D4SRZ6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit p66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_021196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRZ6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054784"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7944529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24867" checksum="D495483CD408E9CB" modified="2023-05-03" version="1">MCVCEGGVADGEAVPVFQQRNLRSRERQKLVQQQQLQVLSKSAKGRERERMQQVRKWQKQMRQKFDNKGGQVPVKHREASVAVRPSWKVLEEMDFPRLFKLSLPAVGEGHDVYRCGAVEFYDKAYNLVTCKNERPLQRINRIFHKVTTTDDPIIRQLEVFVSVGEALKGYLGWNQHAASAHIVEGNVRGWQFVIVSLRGGFVRFEGADEDEGAVGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SU43</accession>
    <name>A0A9D4SU43_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SU43"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037164"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7947174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="582" mass="63770" checksum="356FDBEFDD5ED631" modified="2023-05-03" version="1">MASNPNVSVVEGMDINPEEAECAGWIEVASKKKKLAERADCNAGNAPTTATGSANGGSRTAASQNVLRRVVKASRIPNLPRDHFKTIIRPRGGMDVKKTDLLIFKRSLAKAASLTAEQVFDDTLCTNPFQNIFVVATPFEANARAYARVQEISMGKTVIGLAAYVAASDDTCKGVIRGINVDLSDAELTEMIVNRRNPDALGVRRIKKTPTVIVLFDGQKVPQHVLCDGVRYPCSLYRRQVDVCYACGDLGHRSDVCPKGDDQKKCRGCGVQSPSPDHQCDPTCAICGGAHPTADRKCKKRFQVPYIVRQRRRRRRRRARRGSDTAGGEEAMAEEEPFSSPHRGRSASRGRSRSRGRSGSKSRSRSRGRDKGSSRSRSRGRSGSKGRVQKQMSWADKARMNIPSGQEVTQGILPEQKREQSEILMLKKENAKLKEALRTLRSEFELFRNSREPRAVVTPIPVQAGGSNKRKAVSPPATVESEAMQSDESSAQVPEQNVLASLAAIEESLKQMREALAVNSSTIERMDGSVSHLARRVGFLESKMKIIDSSKLQTTNTGTIPKAKIVQQDSDATNSPQAMLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUU2</accession>
    <name>A0A9D4SUU2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUU2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046384"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67015" checksum="40C3317638F5E4B6" modified="2023-05-03" version="1">MSSEKSNESLRKEEPSPTEGEEEDDEGTASLPDDQDCTVELPSPPDGGYGWVIVFASFICFVIVDGIIFSFGIFLREFASTFNESKGSTAWVASIQTGCYLLAGIGFGFIFLPAAVNISFYFEKKRAFATGIAVCGSGIGGFLMAPCCQLLVSEFGWRGSMLILAGMTLNCCVVGALFRPIEEPQPRPEPVPLKPLLLRIKEARDAMTKWDSVEDGIDDTLITNDGPRRKHSCPPPRIVHDVILNSEERSASSSTSGSNNSPPPPYSEAVKAEQQFNCCHNNNQLRVDHKPAYQAPPVLRKLSFTKSNNSRQRRMTAPEMRPFYRQDILFSASLLRIPEYRSQRDIGSYHQSIANLPKQKPHKKLGCLSPEMTDTLTQMLDISLLTSPTFVTLAVSGFLTLAGFFIPFMYIVDKAILSGISPDKAAFILSAIGITNTVGRVFSGWVSDRPKVNALCINNVALTVGGVATALCPFFETYTMLLVYSAVFGFSIACFAALRSIIAVEMFGVEKLTNAFGLLLLFQGVASVIGSPVAGRPCAARSFDQSTAVVGDTSGRRCAFGTTGRIVSRAATICSRVFPEELRRTPAGQTEGDFVQRPQSVSGDENIPLAFSKSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVC3</accession>
    <name>A0A9D4SVC3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVC3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="162" mass="17039" checksum="5C39837D32A67595" modified="2023-05-03" version="1">MAHGSPGTITAIATDRERCVGGVHFHGDNQRIDDVFCELSSLFPAAVLPEVSADVFEEADCNVRAAASLAGEDIVAAVAGTQDAQADSSSGDKDRPDDAAATRAYSTAEVAAVFGLIRQCCSGMEITGLSHLDSLDKIEASVFNFISKTKKQAKISNIFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVJ7</accession>
    <name>A0A9D4SVJ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVJ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048173"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="125" mass="14001" checksum="7F5DA4B9B493444F" modified="2023-05-03" version="1">MQRMAAFLHQNMAVMMTRIASHANPVHVTTLPDLSASLPTFSGSGTPTFKHWILEELERIQRLARWEDPTLLAIAQGKLRGVAADCHASTGRQLTTWAIWKAGLHEQFGEQLSIIQWQQKVTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVS7</accession>
    <name>A0A9D4SVS7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVS7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039688"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039749849" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7951187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="487" mass="54095" checksum="448BC68D895F0B85" modified="2023-05-03" version="1">MKLAVAAVLLLSTGHLPVLGAADEIRARQDVAEDTEASGDDATGEALFLTPLIEEGKLDEAKSKSKVGTLGADKEVPGHSGYITVNPKYNSNLFFWFVPSLSDPDNAPVILWMQGGPGTTSMLGFFAENGPYILSPDGEEIRYREINWASRYSMLYVDQPVGTGFSFTEDEAGYARNQTDVGRDMLEFLQQFFTLFGELAENGLYLSGESYAGKYVPTVGATLHQNADTMRVKINFKGIAYGNGITDPINMMQLSDFIYPIGLISRSVAEYMSSAAREAAQHIRAGNTAAAFDVMDSLFFGIVTKEDTYFKNVTGYSYYYNYLTSTEPKGTRAYKVFLPKPRARRALHVGDKEFSITRDVVAGHFYDDFMRSAVPQFTEVLENGYKVLVYSGPLDMCVPTIMTENFLAHVAWTHADSWSHAVQQPWWSADGEQLYGYKKTFKNLNYVVVRNGGHELPLDQPEAMLELITAFVEDTEPFTDESTTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWQ1</accession>
    <name>A0A9D4SWQ1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_020250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWQ1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050680"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038976014" evidence="8">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="346"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7952222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="646" mass="72077" checksum="047E8EC3C1F03194" modified="2023-05-03" version="1">MEGVLILIAVTLICEKCCCFQSECNATLPWNVSKEDHPDIPPARLEELLRCPEELHGCSASRVNCTEKEYALTCSCVANCERYGDCCWDAGASLSSPTASTCIGRNVDKYSRREFYVVSGCDPEWPADDVRSSCENATQLGDPFYLIPVTTERQLTYFNAFCALCNYDLDNTSMFWNVSGTPGRNLEVAPPQYALDNIEVFFWPCDDGLVEVGTCPEGADQETTRKCLTYFAPVRYETNETEVVYKNVYCGLCNGAELSSMKCLPKQVVREIWPRAQKKSGFRPNLLSLIRPVVSQGSCFSWHSGKCYIRAPQYHYANALTPTTENETMANMTNVTSSGHEPYNVHSYLTIICLSLSLVCLFLKGVVYVFYGTSRTFSSRYTLCLSGTLFCSHLLFLLGNSFYVPKSVCIGFAVVLHYGFLSTFFWTSVLSFDIWKNVAAVRLTSSRHGGFLIYALVAWGGPLVVITLCLVLNWTAPDFVLSPQYGRFACWIGSLWSQLTFFLMPMVILLLLNIGLYVHIVLQISNTAKRAAAFDFKGGGNKSHMALFVKLAFIMGTTWLLAFVGAFVNVLALDIIVIVLIGLQGVYLFFGFKDYKHLLPRRFKRQQRTAAGTSTAHTELSSLGKDFSSREDVNQSAAVRSSEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SXW9</accession>
    <name>A0A9D4SXW9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_001220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SXW9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057932"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="444" mass="48020" checksum="8039AAD76857132B" modified="2023-05-03" version="1">MSLSSSRPATSAAVPAPDHPPDEVPNVAAALDQSATRCVPSPPSADGPSGMPDIRPSAPTSTARDSSEPSDSTTATLQHALKSDTDMAPSAIRSSTVEDSPSSSLHHHHVSTTSTLCASCQERPALTSQSTAAEVRAPNQHLPNLRDAATMTEASEDELRGSPMAEQPAHAAPVAKAGILHADLRSSPRVPPNPGASTGTGALSDPPAEPTPAVFRDIPLPEFLTGDANQQRCTLNAGMIFDTAQASSTAARRAYLPRAVRLITTRIAHGMVLQPRRSRVRRLVYPCQHTRRNTKLRSALRRHRRLHHYPPTTHVSGQVDQLDTAQVTMSTYRHPRQRCARTGKTHRSSYSSVVARGGFTVPFRIVSRTLPAPALVHPPSTPSAGTSASRAHSRHPVRYRKPPSSRRGTRLGTTPAYFRPVLRPLRFSQSRPPETQWFPIVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY23</accession>
    <name>A0A9D4SY23_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_009259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY23"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045983"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7956420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="603" mass="66546" checksum="D5DD370BE7CD16AA" modified="2023-05-03" version="1">MSEGPPNDQLSSLEADSLSRDCVIRTADGGEFRAHRGFLCSLSPVFQALFSVDYGGQCDVVLHNVTASTMDALLAYYYSNRLGLSEDNVTDVFAAADMLLMDEARNLCLQYMLRNLSIENCLGMAALAQWYHCPNFSRVVLSYVWRTSDEFPDVSEALLVELLTSNELNVRDEEDLLHAIVRWSSSRNVCADEAGADLSRLLQSVRVGLCRSLALEDFCRSHPTLACSRAYNEVVWEAQRQGPCLCSPSPLLLVQYAAHRCLQAQAAIPSDEGHGDSNNGDIAAAAAPRRPASLPQLQCESCGVARNPERWLPRMPYQMLFVVGGWSEGRERDTIETAYHGVALLRNRLYVVGGMREASYLRSCDCFDIESCTWQSCSTMNIARGYVSAVALEDYVYAVGGRNAGERTASVERYNPRSNQWTLVSAMKRRRSDGAACAFKGKLRQRSRIYVSGGFNGQKVLTSVEVYTPCHDTWCLVKQLPSPRCSHQMAVLGGRIYVIGGYDGRRRLSSVVCSGDEDEPLVWRFACSMRIGRSTFAAALFDGDLYVIGGFDGTGTTAEVERYTPSSDSWRPMVPLNEAVSAMAACTVKGLNVCRRLSASAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SY33</accession>
    <name>A0A9D4SY33_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_008185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SY33"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053398"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="782" mass="86641" checksum="3DDF4EFCC52BB5C8" modified="2023-05-03" version="1">MRQWLTFRFIGICERNPRRSISQLIKLERKALVRLNASAKRLSRGARKRRRRKPKVRPTSLEIGEALLEKQAVHVSDVSVSHSAGEEKPIIAVGEHGLAVECGPVKGPAVKTATTNAVVSPQQAKEKLPEPTEDCAMPDDYTEPAIPQTQVECLKQKDKRCQPRTEKPDFRTVTPVTKIGSSFEELRNYKIPKIKRPVPPTKEHGSRVSRTYPVSPVSKKRREKQDEHREELSSSPSSSPAVSTSSSNVLLDKIIEDMNKAYPKVSGCYVSCRDSCPHRNQVHEFPKSPAKCPLEDNQELSKSAILDCAPVSNHIGQKHQMKVCTVCKRKNVSEGLGQDTCIRCSLYEQINKEQAAVKEHGSKERQAVRKPDVPAKVQARRSSSDVENKELVTRTPTSPRSRSKSKSRTSNTDNVSTASPQANEHNNVLRKRRRKTYLTKQIISSSDDSCTSEDDICAAAASAVPASQDGANSLQYRQPRPQRKCRALSESPQNVTEEPAQKDDSQDPEEPLTTVSLVDAVFGTPKASIGTIDRGCAGRGGRLYQMLEEYVQNVERFLAALHQCTPGYRDRLVSTLLPEGIVGLKRIVQLVWRMEAELQCLGRDRVSDLDKGVFSLLMEHTGNLSKTTAEQDLPTFMSFQVHIEPQLQTLADPLCQEVADDGQHTNCIITAVRRPSDSLSEKGEMAGQPKSPQATTVDGAVRGTAHTTATVDASRLEQGQQSTGMSCPPRAASGILKNDVLYDAVIKNPVIREKDHYQKKVPVKVLASNLHYIHKKIACPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYM1</accession>
    <name>A0A9D4SYM1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_014206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYM1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028791"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049614"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7957008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120742" checksum="4623D0682E92A1F2" modified="2023-05-03" version="1">MLSDSIKASPKDVEREKRSRPKVPQKQPFHRIRTLLILKTSPVRGILPFFDPFLRCRAAASAKPNKQRPPPAWCRARLLPRMEYPVEGEDITPDEVSQDQGWQCAGTRRTGARKASANPTGPLPADAPRDKHDGSKLKAKVLRAGRMPHLPREDIKVVIRPRGGLDIAKVGAVVVADAIIAAAGISNDDLHQDTLCPNMQQNIMVASTPKRENAVRYVRIREIIVAGRTHELSAYETAPHSTCKGVIRGIPHQDGPNVIDAKIRIAQTGTVIVAFDGHKVPKFVKYGPLLVRCALYRKQVDVCYACGRLGHRADVCPSPGDVICRGCGATNPDEQHQCTPRCRLCGGQHLTASKDCSQRFKIPYVVRRRRGERARAARSKSPAASPPPDLAFGGNLEARSKTGSSTASRQQKPALSWADKVRTDNGEPAEGAASSSQQSGPSGYAQELERLRKENAQLRKENAQVKEEMKKMANEIAEIKKFTLGQASNSSPAPIAMEVPEASTGGSGASKRRAIESKQNDATGKTLAAMEEGHYLFAAFLPLSWWAVGTLPKALSGFVPLVLLPLLRLEAEDNFVARYYSRDVLTAAALLSLALRSKSQLSGLLTRLSLNVGLSFGLHVRWLFFSFSLLAFLVGLVLSEGPASVLFACLVDTVIRIWYDDTVRMFSLQSGAFGIRRVSETRVSISLSADQQKRDSIVSLPNDSEPSSTSDLQPSEPKPRRPSILKDPSRFPEVGIDWAALAKVGGESNPSASRMPLLLARTPTAASVPPGDVNLRRRASAQSVDSLVDEEECSMVLDKEVQERVYEGLRRTFLMGPTLVIISATSTSCFQYPAWTVLSSHLSITPTMMWHWTLITFPSCVLSSALGLIYVYVFMFKQYEYVLDPALQPRMLRFTARHLRKTPHTSMVIVTAAVTFEQRQEEKQGDATDCWSRFPWQMVLLLGAVQVVSKVIEANSTVATSLRASSWMHQSPLTVQIVLTVVGALLSETMNNEALSRLLLPLTIHAAVTTRMHPIYYAIPVAVAASSNLIMPITLPLVILHEVAEVPLRHLVLAGLIMKTALLSTLIISMNTTGQYIFYLSPTVKALNSTGPASRHQAPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYS8</accession>
    <name>A0A9D4SYS8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYS8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050209"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF5">
        <property type="entry name" value="PROTEIN TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50275" checksum="B842101C262A3C7E" modified="2023-05-03" version="1">MLQNFTISFLHSGYGPLVIELMRVNHEQGSSLVDRCHFLWVVGYFTGLATALGLSLHHVRPVLSIEVVGLLVFEAIAVCQELDMSQHQSAEGSKLLKKRYHLVVRAFREFIAAIGTYNSRCKGVGDDMRRLCVSLARLEDLRNIPLLLIRKWSAMPIQALVDLIITNHLLLLILEYAQKTEGGLDIDILGHLSHVLVNDCVFTMMHHVAGDLKRPEALFHPNILSSFVNILNEGAEIPELYEDLVGYVMNRYLKLAGRNPELYSEHIPGMQRSGSASSTQPLVVPPFYDDDNSSDSSDCSDEGDDNALYWCFLQFEYDSDPVGQIVEHLRRNDVRRTRREILNQLKCKRIISNTQCERLEQKEKQFLENSSKPKEQPETQDMESEERSEITDLVLKLKGMGFEQQLQWIQKKFLEVCYVKLSKQYITATYHKWRVMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZE5</accession>
    <name>A0A9D4SZE5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_001306</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZE5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044602"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056087"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="434"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="544"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="702"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="860"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1092"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7961063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1131" mass="124069" checksum="3AC39ADB3FC36219" modified="2023-05-03" version="1">MSFSFKFDIPDAEDADLNQIEPVGSERKHLAKPVAPYEEVLPRQELENLHESLEKSMLDLTSIKVTFLVGGQMESLLRGDVLEATEGNLDIVPSVYEGGMKVWECSIDLAEYIENHLSIDDESKVLELGCGAGLPGLVACLKGAFVDFQDYNKQVLELITIPNAFSNIGARVKKRCHFFAGDWSALADNIAPSHPRKKNRAQGPAVWSPLRMLRGILATWWRRQFTRFESASFNRCLNDTTDPPVQQVVPPNADQPDGYYYAVAEFGFSADVSTSNELLVGAPGLIDWTGSVIKYTIPNDTSETLNLKVRGLLDAGKIPRIQQYIGYSVTSGRFFESMGPSMVAGAPRETEDRKGAVYFFTQETASSNSLRVQMKKEGEQMGSYFGAAVLGIDLNNDNYSDLIVGAPFYSLKETTGDEGKAYVYISNGASLSLQHGQLMGSSVPGARFGITIVNIGDLNLDGYPDVAIGAPYENDHGAVYIYNGGKNGLKTTYSQRIEARSQISQPQGFGISISKALDIDDNEYPDIMIGAYKSDMAYLFRASPIAYAKAWIEIPTGRMSSKTPKCNRNNVYYYCIEVLACMTYSGKFLNEELGFFYELEIDSKRADKQSPRGGFELPNGIIAASVSAEKTIRMGVENCFSEVALIDGNVTDLVTPFEFRLSFDLADNLKRGKRDSFCKECPILDQSTVKVVTNRTAFQVACGADNVCNADLELKASIEGHENNSPLVVGKDSTVTLNVTVKNREEEPAYLAEVEINLPENVDIVNIGSCEKKNSSTLTCDIGNPLNSNVETKLAVKLGLTKLKKKLEVKVFARTLSLDVDRSNDHVLIALPLIHHADIALQGSASISQLIYNKSTDIVPVVHTFTMVKYYDSPINKVAVTISVPLRIVGHKANFMTLLSVIADDGSRTKVGGSCNSSVASLRKRSSSTTSPPITRQRREANPLAILEGHFPAAQIKSLTLDCSGAECMSFTCQMGPFADKNKVAKIELNMIINVTLIMEQVGIPDTVDIISEGSLTILDETEFTHYVKQQPKQAMIVTSLVKEGPPATPSLAWWIYLLIVLGGLLVLLVIILVLYKWGFFKRQAKEDLERSKRESLAASSAPNSPTTEALPSIPSDDPEVRRSLLSSENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZF9</accession>
    <name>A0A9D4SZF9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_002475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZF9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043555"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7961108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="468" mass="52120" checksum="9368B704B71ACD69" modified="2023-05-03" version="1">MGHVTTFAGIGSIGTTPAILLFGTERDSGDFSTCIPIQLKKKIEVVEWHRQAGRNVHATARHFSIDRKRVREWDKKFDSLLQQNFGTAKLRPKLSNGAPVFSEEVDDALFEFLERERSTGRAVSNRLLSEEAVKIARSLQLGNFAVSSQYIKRWKKRFGVTMRQSTNDSQKTPDDFSKAAKAFRSAVNSLRARHDYTPYNMCNMDQTMVRMDSPASRMNNVVGESTVRIANTACARRGFTVALAACASGHKLPAFVVLKEPSGSIPTKAFMSLRIPGNVCVTASKNGWMTSDKLQEWLARVWGPNNDDVRRLLVLDQAPIHKTQAAKDAIEERDTDVVYVPAGCTSLLQPADVFWNRPFKANLRRSWEMFMRKGERTPKGNLRKPSRQDALNFVSEAWAAVTVETVVRSFKGCGISNALDGSEDGELHDCLSDIGAVAPQNPKDLQNECLDLVFGSDSEESFDGFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SZW5</accession>
    <name>A0A9D4SZW5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_009367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SZW5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10340" checksum="0C03C826BC0A9DE8" modified="2023-05-03" version="1">MPAGVGRGRHNRSRDPEAARGGNRSQPLKSLSLGTDTQPGEKRPQWSTKKARGDVTGRLRERTSGSEHEEATTKQRPSKQPVAYEMDTDSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T011</accession>
    <name>A0A9D4T011_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_018465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T011"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031884"/>
    <dbReference type="OMA" id="ADGFAMW"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039776534" description="Putative alpha-L-fucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="12">
        <location>
            <begin position="367"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7962879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="463" mass="52895" checksum="29DD6C8AFFBB759F" modified="2023-05-03" version="1">MSPLRVLGTGCLLLLAQAALSTGRYTPDWDSLDTRPIPDWYDDAKIGIFLHWGIFSVPSFGSEWFWWDWQGSKVPAFREFMERNYRPGFTYQDFAPQFKAEFFDPDRWAAIFKKAGARYVVLTSKHHEGFTLWPSAVSWNWNAGDVGPRRDLVGDLARAVRKEGGIRFGLYHSLYEWFNPLYLADKEAGFKTNDFVARKTMPELVEIVTKYRPEIIWSDGDWEAPDTYWNSTLFLAWLYNDSPVKDTVLVNDRWGKGTPCKHGDFYNCKDHYDPGTLVVHKWENAMTVDKESWGYRRNARLTDYHTIEELLAELASTVSCNGNFLLNVGPNSDGVILPAFEERLTQMGTWLQVNGEAIYGSRPWKSQNDTVTPGVWYTSKNDTVYAIVLHWPKNNKLALGSLSLSKGATVTMLGLDGYDFTPYTATTPENWNNVGRTVITFPSLTPDVLPTPWAWVLKIRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2B1</accession>
    <name>A0A9D4T2B1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_000561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2B1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7967607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="418" mass="46048" checksum="50A4CE1AA2B90D54" modified="2023-05-03" version="1">MAMQVTVQGEDISPEEFQCAGWTTALSKRKSTKESPPAAGVPVTGPPYGKNVGFQSPANVKKRLADTSRLPRLPREHFRVIVRPRGGLNVKNTSNLRIAQALTTAAGLSAADTTEDIICPNAMQNIVVISTPSPANARAYASLEAITVGQTGYDVSSYIAAPDNTCKGIIRNIDMEFDHEELRRLIIQPRNPNVLEVRRIKNSTTVVILFEGLKVPNYIMCGPSMITLYRRQTDVCYACDRPGHRADVCPTPENAICRGCGISSPGDQHVCSPKCAFCGGPHPTADRSCRQRFEVPYIVRQRRRERRDFEKNFPPKGGPSEPADKPRSRSTSRGTNGGAARGCSRSKSRSRSRSRSRSRGPAVRIQKPAATETEWADRVKGSSKKETGDTTQIPIHVQVYNQATHFSRPETYFSRPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2C9</accession>
    <name>A0A9D4T2C9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tripeptidyl-peptidase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_023145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2C9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051609"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="10">
        <location>
            <begin position="181"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="11">
        <location>
            <begin position="320"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="9">
        <location>
            <begin position="422"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="9">
        <location>
            <begin position="541"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7963822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="89833" checksum="D483157AE030A767" modified="2023-05-03" version="1">MELMHEVIDRHGVVMLNSAGNHGPALSTVNAPGTMPTSSIIAVGAYVSPDMMLAEYSLREKMPGLGYTWTSRGPSPDGDLGVSVCAPGGAITSVASWTLKGSQLLNGTSMSSPHAAGVVALLLSGLVARGLPYSPYSVRRALENSAQPTQDPFSMGHGLLQVDRAFEHLLQHGQCTERQFRFRVSCGPNRRGLYLREPQQSAKPSVHTVTIEPILLNEERADPLDKIGFELNLSLVCDAAWVSTPALLNMTYTSRTISLRLDPCGLAPGAYYTAVKAFDVTCPEKGPVFEIPISVIKPKPITKEDGYQWCIEKLTLHPGIQLKSRDPTNVAHVVVHAMQLRPMYSCETAEFQKTCMLPPSAEASHAFSVIGGLTLELCLAKWWTNLGDVDVDCTLTFYGLQPNPSRLVMRSSEGVYRFDVTSQLRPEEVSPAASLKQHVIVLRPAESKVRPLGARDVIPDGRVIYEIQLTYNFALSKATEVTPSFSLLSELLYESEYESQLWMIFDNNKQLLASGDAYPGRWPAKLPQLALLFTLCFFNMQYSTKLEKGDYVLRVHVRHEQSALVERLSDMPLELSHKLPSAIALDAYRSQGQAMIASAKKFAPLMTRPGAQVPVYLAPLPSDNDRQVKMTPPVPARKCLTLEQKVQLIREVEKGGRQKSEIARQFGIPPSTLSTVLKNKDVVLDGFEKKDTNDDCEDCDDLYEAVNSIVGGDLEGNFESFAMADADVPVVAPATDAEIVDLLRGPDEEEEPLDEQPREIPTVAQTQEILSLLRNRVECAGGDHDLIICLNKLERAPLASSRSTRQSQLTDFFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T3B4</accession>
    <name>A0A9D4T3B4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_009561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T3B4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043554"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000395">
        <property type="entry name" value="GS homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF20">
        <property type="entry name" value="AGAP001560-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7968549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="293" mass="31149" checksum="A7AB7C23B2E14116" modified="2023-05-03" version="1">MDRSTREEAQRQDLGEDEDDDGLCHEASSGKELAGGMTSLPGGAALLVSGSPLQREALEYQASVFQQQHRHHGIEHYASAAAAVVAAAAATVAGDTEEGRKSTRPNCGGSLSPVLGVTDAQIKSEKGSSPNGVSSGSSAVGDDNSSGGGSGKRVRTAFTSTQLLELEREFTSNMYLSRLRRIEIATYLKLSEKQVKIWFQNRRVKYKKESSHGRRQLPPNHHCRCSAALRLSRGRDLSPSAKCEAAAKDTVTSTPSGDSDDEDDGELNVCSSSQDSADACAHAMNTDCEESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T406</accession>
    <name>A0A9D4T406_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T406"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7969043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="130" mass="14610" checksum="E9EA8773F5B9A91E" modified="2023-05-03" version="1">MLIWKAEFDLQEYLSESGFHNQRAPSCSITDCPDQDQEMSTAAATKRRRKLKATVSFGPRSRSTSGLDCCLKASFAGLLILLKMPPTAAGGENRCDLPRNARQRRFTQLQRQRSVTTTKLNQLEAASLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4W1</accession>
    <name>A0A9D4T4W1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_003723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4W1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027923"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7975627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="283" mass="32658" checksum="379506DF01B23CAA" modified="2023-05-03" version="1">MSDIVRPPKSILEEGPYIYADILDFKNLQELVVNERIDWLIHFSALLSAIGERNVPLAMRVNVEGVHNVMELSKQYRLRLFVPSTIGAFGPDSPRNPTPDLCVQRPRTIYGVSKVHAELLGEYYHHKFGLDFRCLRFPGVISYDSEPGGGTTDYAVQVFHDALKYGKFTCYLKPDTRLPMIYITDCLRALVEMMEAPSESLKLRTYNVTAMDFTPKELFEEVHKLVPDLKVDYKPDGRQEIADSWPQVFDDSNARRDWGWKPTYDLAQMCKVMVDNLRPIYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T535</accession>
    <name>A0A9D4T535_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_024129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T535"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034621"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7973321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="30968" checksum="669ACA5591C465E5" modified="2023-05-03" version="1">MVSPVVGIRATSFRAIHKNDFDAKSAVRRHKTAMGNLWVKDRANKQTGMTRRENKLVQTTWNTFCRKHPDFGSLLLLAMFTQHPDYQALFPKFKGRELRQLRDDAKFRAFGQAVGRQLTAIVDSVDDYDALLTVARKNAVEHAHREGVQAEHFEGFFSAALSQMIEGNKSAMKAAAITAWEKFFETLKMITKHAFDEAAKEAENSKRAASSKSAPRDVPPSSTGNPAYTVTSSLASPANATQKATNTKSPLAVKSVIKGAHSERQSFWKSGAKGKGGKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5C6</accession>
    <name>A0A9D4T5C6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5C6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036622"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF10">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7972243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="445" mass="50880" checksum="7153A5530CBEE5C2" modified="2023-05-03" version="1">MTHNCVTIIPVEYPRSDSSPLSEQEMCVYLMNKVCLCVEVGNVQLATAHEIIDIIAEDDTEINFPAQVKDVFALWMTSPLLELQLKPDHRPYLIRERWSEYLKKYTFATKQQLDSDEPVLTLQRNVFLEKSKEKEITDLKLLKMLFAEAKGNVLDGRYPCETEDCMVLGAIQARLELGPYDPLKHTPEFFRQGHDCVFAVQSRIRDFLPEHACRSHWFLLGLGAKNGPERRLSEHYKAIASNVKDSRLMRKYLEFCWAFPYYGSAFFSGQVERPVTGIAALMNHYDLPVLVAINRDGVHVMDPSQPVVLLSLPYKQLSWDYACPTQPDNPDCLPCLFLQFQLPGQNETSVLQIFSRQAILMDALISTIVDELKKRASWIESEAEAVAVNSRADDDIQVPLTVKKLRQEQGLSGRLRKLSIAKFNSSGDYLNSKGSLEFRRDDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7M8</accession>
    <name>A0A9D4T7M8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_014384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7M8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001760">
        <property type="entry name" value="Zinc finger protein 1057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7976453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13849" checksum="061C4FE4AFD2BFA7" modified="2023-05-03" version="1">MKKSNRMSKVVPAGMASITLMMQLENGLARKRARGVSHWMCRQCNYTTRHRGHLNQHMVVHSGKRPFVCHLCPMAFSRRATLANHVQLHDRDKKFLCRFCPMAFNIKSALDQHINTHLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7Q6</accession>
    <name>A0A9D4T7Q6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7Q6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10815" checksum="2225E467620611ED" modified="2023-05-03" version="1">MAACYAGRKALCFLWSQPSGVASVGRRFVASAGQGSPKNTSDTKKPPSAGSKSAPPVQPNVSGATEGYKVKEYFEHSPYSFYDIHADMFKLRLPQPSCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TAS7</accession>
    <name>A0A9D4TAS7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TAS7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="261" mass="28935" checksum="9B3A428DCA593275" modified="2023-05-03" version="1">MLGQSQTALLHFEGPQLPQLVYFYGGEMPCRCYQPTRQFCPICRTPGHRPDVCPNPMARACDVCNLSNPEAGHTCVPKCALCGGPHLTAAKECENKLKCIQTWRKPATTEPPSAHRSPPASSSRSKSRSCLQPRPQSQSPKRRSRSMPQHQRQAATTAAPDDNGFSQHQQNREASPTGIDANKDRKPQETVPHQAITDLQHQFEAIRTQMQAFMDDIRTPQLGQLTKTALDGTQAAVAEIEAPKDSTAKDKTHHTELRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB23</accession>
    <name>A0A9D4TB23_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB23"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="134" mass="14995" checksum="2D7FF1F4FC28F320" modified="2023-05-03" version="1">MSRLKRDSEPTFHAAALQAETKNRRLPYIPLPERHKCSSSRTRLHEWGQLFLVHRPHQIEAAVLTLMLQLLQPVLRVKTGEPVETHMGAPLLLSCAVRHSALLHVCRNRSDGPCGLTMGKKSKGPSIEPAGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YNK9</accession>
    <name>A0A9D4YNK9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YNK9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038814"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27442" checksum="AC4838130A6A25E2" modified="2023-05-03" version="1">MHDKVCACGSDVHPKVVTAVVEHNSQVFGAHERSVLREGGVDVMLSNASSFSLGMGRHALEYAALVPEMPHCGWLPIPPHRDRGLEISTTVPGGHDPRTPFTTFVRVSDEARLIIARHVRSLHPDARVASGTPPRVLPRTGLNRRARAFLLRLRIGCSRTADRLFRLSGSGNPKCVQCPADETIDHILLQCPGYDDHRRRLFGAFSRLGLPHLCLDELLFPSAQHSKVLQAFHALLDFFGDADLFTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQP7</accession>
    <name>A0A9D4YQP7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQP7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032654"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="377" mass="40375" checksum="4524503D79BC337A" modified="2023-05-03" version="1">MPRCEARRSSSSLNPPDDNGLFATLRNHIASSANDVEDQFRSRLNAGARLSSEAAGATTLASSRAGSLADASVSPRRLSVRKESSVGSVHSSGRDTPSRLAADGDTGEGGGSFGFGATVAHISSAFRNYLADMTADPPSEPSRGVDTEERLPTPPVREESLGRFSVAPVAAESPGRVQEPAKSACSNGVSMSEIRDDHSGLDGAAASCDFPRRSRDAVLDPRTLAGPRDDSARAENTESHSVPMSHFPTTGGKKSRRSSSLVQLKRFAKFRLSLRSGDSAQCDERPIIQDGGMSSYERNLYLYHEEMPDRPRVATLLSSLANYEVAIPSVAGEEAQAAPKLDWPRCPYNPPAQFWFVVRSHWRLDGASVWTGIVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR33</accession>
    <name>A0A9D4YR33_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_024344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001108">
        <property type="protein sequence ID" value="KAH7985058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR33"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7985058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="210" mass="22382" checksum="9F2B306D545EDA2B" modified="2023-05-03" version="1">MASREKAKGQHATTKSGRLPRRWVACFVLAIIQLIIGLGLLAVGAADVVFTLDHKFVSFNVVTCLATYTGDKTTALFAVILSKVVLTYACHVLGGVCAGVAVPDLCRNGAGLVTFDTFHRDVAAKQMPQNQTSSAPPPRLLPAAQLGHHVQEAPGTGEKLTVVTLPEADVIYAVPENSYVVRRPEGSYVAPPGNSRLAPFFPTYTRVAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YR57</accession>
    <name>A0A9D4YR57_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024392</name>
        <name evidence="2" type="ORF">HPB52_025063</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001138">
        <property type="protein sequence ID" value="KAH7984995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000484">
        <property type="protein sequence ID" value="KAH7986320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YR57"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10265" checksum="C0783BF176B05435" modified="2023-05-03" version="1">MSSLLTVRLNPDWIEDQAGIDPSGLYYDGVAAFTSATHQNPRVATEKLPAATDLHTRDRDLLLASFYVCFQNYNEIVNMTENSTAKLSRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PAZ3</accession>
    <name>A0A9D4PAZ3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PAZ3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053791"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="286" mass="32369" checksum="FA318B2FDAA97604" modified="2023-05-03" version="1">MAILNVAEAVMDVMVEIFLPPPMNLQPFNFQDPNANQPRPKVAPAYRQALGDSSRSVSEMLKKRKCTVRVHKRYDVHPLCEDLLDDYVQVNVGVKTAPFDRNVEQIPIVCDEAEKNNRLVTVLEDILNEGRHKVIVFVETKQTVDDVATLLLLRDWPVVGVHGNKRDDELDWALAAFRGDGALVLVSTDMCARKLDVAGGVRYVINYDYPRSSEVYKRRLEHASHSNGVGVAYTFFTHQDKRHAWDFVSILCEAGVVVPRELTEMAKETARDRRVGVSRTGELRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PB55</accession>
    <name>A0A9D4PB55_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_002663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PB55"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047873"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="220" mass="25243" checksum="7DD8E59B5F411468" modified="2023-05-03" version="1">MAKQFEEFRRELRLEIRSLKESVKYCSDTSDSVSEIQRYIKELKLDMKRLMENNVQLEHEKQRLRDRIDELEQYQRSNNIEVKSLPDGCNATAAIKAIGMKLGETIDDLDVDVCHMVETSKGRAKNLIVRFTRRSKRNAILAKARKAPLTTQSLEYGGQSRPIFVNEHLTRKNKQLLGAAISRKKLLAGSMSGAAMAECLHVEGTRHLCCTSYRWQMLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBI3</accession>
    <name>A0A9D4PBI3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_001005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7934821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBI3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7934821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="89" mass="10238" checksum="E290FE5EE7C54268" modified="2023-05-03" version="1">MTKEVYLLKLLTNKEHNIKESRPLPEYWGPGEDVEEEDDVCISHLERPEISAGIHLDPGVESDVVRRWGLRDRHPIQERQIVAVQAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBS5</accession>
    <name>A0A9D4PBS5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_004566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBS5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="254" mass="26557" checksum="DA7881720463858E" modified="2023-05-03" version="1">MLPRLCPPVPPFHPAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSATSSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPPSTRAVPPGPQPSHDHDLPSPATTPPTSRQATSASIPAPNHPPDEVQEVPAATGHSTESSVFSTAWAHGPSDVPAICTSSPTSMAHDTSATSGSTTATSPHALESAIDRDIVTPAIRPPIAEASPAMMSDEPVFPSTSTLRILPAATSLALAVSCSRSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDD7</accession>
    <name>A0A9D4PDD7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDD7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057932"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7935676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="507" mass="54529" checksum="6D2237CB3B3C5D7B" modified="2023-05-03" version="1">MLPRLCPPVPPFNRAYPRAWFMQLDACLAVNGVTAQPLMHDILLDALPAELRHLSAASSSSPQPYDDLCAAVLARYGETYRPLPGTREFRVSPSSTRAVTPGPQPSHYRDPRPSTSAAVPAPDHPPDEVPNVAAALDQSATRCVPSPPSADGPSGMPAIRPSAPTSTARDTSEASDSTTATLEHALKSDTDMAPPAIRSSTVEDSPSSSLHHHHVSTTSTLCASCQEGPALTSQSTAAEVRAPNQHLPNLRDAATMTEASEDELCGSPMAEQPAHAAPVAKAGTLHADLRSSPRVPPNPGASTGTGALSDPPAEPTPAVFHDIPLPEFLTGDANQQRCILNAGMIFDTAQASSTAARRAYLPRAVRLITTRIAHGMVLQPRRSRVRRLVYPCQHTRRNTKLRSALRRHRHPRQRCARTGKTHRISYSSMVARRGFTVPFHIVSRTSPAPAHVHPPSTPSAGTSASRADSRYRKAPSRRRGTRLAATPAYFRPVLRPLRFSQSRPPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PDH0</accession>
    <name>A0A9D4PDH0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_012964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PDH0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032042"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7935721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="233" mass="26399" checksum="DF97CF16CADA74E3" modified="2023-05-03" version="1">MKTPTKAEWERVAEGFASRWQFLNFLGAVDGKHVAIVSPPNSGSKFFYYKCTFSIVLMAVVDSECKYVLVDVGAKESDFGRDLTDGCLDIPPLGSLPGTSTNVPYVFVGDEALQLRKDLMRPYPAKQLDDGKRIFNYRLSRARRCAENAFGITTARWRILLRTISLYPKNVDFVVKAACVLHNFLTLHNPHAHQFPDRGRQLWKCCWRALAASSAGQVPWQWRLPGLTRTQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PED1</accession>
    <name>A0A9D4PED1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PED1"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7935863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="159" mass="16908" checksum="304E40BB890E49EC" modified="2023-05-03" version="1">MAANDAGGLSEVPPRDSPSPRLGCTTGAAEATQRALNNQEAMDAEENRASGEEATTAKTATAATTQIPREGELAAILAAITQINGRLGNMDARLGAVESQLHTLPVKRERLATKVASTSVRNRFASLKKKKERVERIKEAIAKRRGRLETSGKGDAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH57</accession>
    <name>A0A9D4PH57_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_021172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH57"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044540"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="8">
        <location>
            <begin position="433"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7940092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="565" mass="63762" checksum="11217A9322CCCD76" modified="2023-05-03" version="1">MGLGTDGGCIYVTDMDIIERSNLNRQFLFRPWDVGQLKSVTAAKAVAKMNPEVSIVSHCHRVGQDSEHIYTDDFFGALDGVANALDNVESRTYIDIRCVQLSKPLLESGTLGTKGNVQVVVPHLSESYSSSHDPPEKSIPICTLKHFPNAIEHTLQWARDEFEGLFKQRPEEAMKYLEDPTFVENTLKLPGDQPADVLASVKQQLVDERPKSFADCVAWARMHFESQYSNQIKQLLYNFPKDHQTSTGALFWSGFKRCPHPIEFDASEELHMDYIVAAANLRAAVYGIHNCTDRQEISRILERVKVPVFKPKSGVQISVTENEASSRTGGLDDPNRVSNIVKELPLPSKLMEVSITPQEFEKDDDTNFHMDFIVAASNLRAANYDIPLADRHHSKLIAGKIIPAIATTTSLVAGLVCLELYKLVQGHNKLKLYRNSFVNLALPFFGFTEPIAAKKSKFNGREYTMWDHFEVQGELTLKQFLDYFKTKHEVEITMLSHGLSILYSFSMSPPKVNERLDLPMSEVVAQVSKKPIEPHVRNLIFELLCNDKNGEDIEDMPPVHYLLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHJ7</accession>
    <name>A0A9D4PHJ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHJ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="133" mass="13379" checksum="C486A82262B6F909" modified="2023-05-03" version="1">MRAQVPPPAAVSKNNPPAVALRPLDAEPVPPLGPKEPAAVFPDAPPPAAPGHRDTSAAGDQGGGMMGNFGGGISPGSLEGISRLRLCMYVMGAMAVLLLLFAVYAYAMFDDSGEPRAVPGVDTASGLGGNGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIG7</accession>
    <name>A0A9D4PIG7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rho-GDI gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_012000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIG7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057437"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7943857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="202" mass="23342" checksum="74868F0874FA4217" modified="2023-05-03" version="1">MADDKVQTAVPEVEDDEDHPNYKPPAAKSLKDIVEADKEDPSLQKYKETLLGAATAEAIVVEPDNPNRVLVKKLVLVVEGRPDIVLDLTEDFDQIKKRTFTVKEGIQYRIRIEFFVQREIVTGLKYVQKIYRHGLQVEKMNQMVGSYAPKKEIQSFTTPQEDMPAGMLARGSYTVKSLFTDDDKHEHLKWEWTFEIKKDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIQ0</accession>
    <name>A0A9D4PIQ0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_003047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7942977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIQ0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="571"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7942977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="661" mass="73121" checksum="E29F40BBBA7CD15F" modified="2023-05-03" version="1">MSAKAFESHRHDTFFRRSLGILAMLVVLSFVAFVLRPMGYMKGPFSFGANQPAAAIGMSVEAAVFRYRCEQASEDAREAIDYYADPCEDFHAYACDRTRRRDRGELHDERSRLQRVLFQLSLLNDTNHVAVQAAVLFKSCLSMPLSLEVVLQKNMLEFLEVANLSAETMLGFLETPEDVANLSALNSFAHGIRSLASFESGLNGTVVVSFSRPFSAYLNRRSARAVIDSVTQLLDIPKDHTYKASNLLLADQELATLLIEANTFYVTLEHLASATGGRITSSAWKKIVQDYGFHSANALSSAPIVSVERLKQVFTIIFDKLNPQETAVYTIAHALLPTQILEVLFDDHRTYACFRLVSETLGTTWQDLESYLLGFFDENHEAHSVAYSVASTFEKMLEGKFAHDKQNSGVAIAKLKKLRFDMPSVEGLANFVPSTACRGNLSEHSLYRNLMRCKESRQNAAAANNAALRRRKRSSLATSSILLSVESFRPSSFCHGHDSLLNYATLGTELAATLLRYVAGPLDGAAVSHSTAEWKKAVFPGITANISTCLSRSSRSSELGRLLDDVALQTVAFQVALRASKSQAGAWARIEKAPDAPAWKQTYFVKYCQSLCNDDKLNRSAATLDVALACNSVVMNSPEFAQLFRCERGDPMVPSEYCMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKT0</accession>
    <name>A0A9D4PKT0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKT0"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11051" checksum="DBA79889BD98D3B9" modified="2023-05-03" version="1">MGLLHSSKPPQPVSQDPPSDYGRQQSQSLQQDKVNCERQQLGNTDQDVTRILIPMLFAAIKALVRGNPSSRSLPEVEAILTMEPLVSTFYAPQGRAPSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL89</accession>
    <name>A0A9D4PL89_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_007474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL89"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041251"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7947043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="154" mass="15746" checksum="74530BEAA3B80F07" modified="2023-05-03" version="1">MPIKAVCVLSGSDTTKGTLHFTQEGDGKPVKVVGEITGLSKGKHGFHIHEFGDNTNGCVSAGAHFNPHGKEHGAPTDANRHVGDLGNVEAGDNGVAKVNIEDSVISLCGEHNIIGRSLVVHADPDDLGKGGHELSKTTGNAGARLACGVVGITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMM7</accession>
    <name>A0A9D4PMM7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMM7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029585"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.10">
        <property type="entry name" value="Arylamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.150">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="300" mass="34214" checksum="962EDD26ECC0ECE9" modified="2023-05-03" version="1">MVQGQLRLALNPSSGLRPIPTQHYLDFLRLQTPVKPDLQSLNSLISAHLERIPFQSVDTVLGNIEPLDDGAVFSKVVKEGRGGNCFELNSLFARLLLALGYKVRVRCARIRWAVPEDVPPAPVDHMVLCVTVGDREDQGTPFLVDVGFGGPCPQRALPLDGDAMPYRLRVLDNDWTKPIEVSILSQDEPGQSSRWLPLYQVFAYSHEWPDFMDKSWYFATYPGLVFREVLAVSRYEEDCWLTLRNRCFTRRRCTSTGIAEVEERRLIDNTVDLLSLLGDVFQLKLKPDMDEKVRRQLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP14</accession>
    <name>A0A9D4PP14_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_015703</name>
        <name evidence="4" type="ORF">HPB52_024506</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001236">
        <property type="protein sequence ID" value="KAH7984834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP14"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052137"/>
    <dbReference type="OMA" id="EKKPSRH"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23021">
        <property type="entry name" value="zf-HIT_IN80B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="152"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7984834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="278" mass="31250" checksum="8450585C9E6D3BB1" modified="2023-05-03" version="1">MPKKREAVKAENDVLGQLPPHKRHKKHKHKKHKRKRGGTEEEALSPPASPQSGDGGKPALKLKIKIGGQQALEKNVTRSDEPSSHSDDEEEAWLEALESGRLEEVDDELRKMKDPTLMTARQRALLESKSKDKDEDGPAAVQVEPIKEMTEEMIQRRMQRAKKRKQQAEEKKEKDKKQTIERLLKKSESRLRACKKPAKKADTPKVSLLRSSEAGTLLMFPPGLPFPLPPAVAPCEYPKRALCSIKGCLNPKKYSCSKTGVSLCSLECYKANMLQMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP15</accession>
    <name>A0A9D4PP15_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HPB52_018487</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
            <tissue evidence="22">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP15"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037181"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="20">
        <location>
            <begin position="87"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="19">
        <location>
            <begin position="199"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="18">
        <location>
            <begin position="312"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="21">
        <location>
            <begin position="538"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7948100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="638" mass="70903" checksum="ADA0EA76C834C367" modified="2023-05-03" version="1">MSLLLKHTLKRCRTFSPSRNDVVLLLRRFVSETAPGPHMGVPVVEERPLDLSQGKVKREPFVKNMFIGKMERAMLAYPEVLTNEKLEELEAMVEAIRRFYDENVDTAKIDREKNIPKEILDGLKALGLFGLQVPTEYGGLGLTATEYARICEVTGKDASLGVTLAAHNSIGIKGILLCGNEEQKRKYLPKLATGEHIAAFCLTEPTSGSDAASIQLKATPSLDKKTYYLNGSKIYISNGGFADIMTVFAKVRVEGVDRKKEDKITAFIVERAFGGITSGTPEDKLGIRGSNTTSIFFDNTPVPAENILGEVGDGFKVAMNVLNNGRFGMGAALAGGLRELIAYTSKYAVERVQFEKPLCDFYLIKDKIYRMTSLTYAIESMVYVASAIIDVVEEPDCALECAIVKVFSSDAGQYVVNECLQIHGGSGFMRSLPIEQYYRDIRILSIFEGTNEILRLFIALMGLQYTGKQLADLIFTVESMIRSLLLGVDDVWGGFCSCDDEHLFTWRLHSEKSCSKTCHASCTRAMVMFVAKTCSPLQEIIEQQMVLANLADMVIQIYAMACVLGRASRSYCIGLPNADIEVDLALCFCHDAKKKVKICENEIDEEISNYVHVKKRQIADKVFQDKAYFAVHPLTKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPL4</accession>
    <name>A0A9D4PPL4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="17">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_017325</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14 17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="17">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 17">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="17"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPL4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031554"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053529"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14 17" id="KW-0274">FAD</keyword>
    <keyword evidence="2 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 17" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="18">
        <location>
            <begin position="460"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7947978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="550" mass="59452" checksum="10FBC8B8ECC2E50D" modified="2023-05-03" version="1">MNTIQIAEEQDLVVIGGGPGGYVAAIKAAQLGLKTTCIEKNDTLGGTCLNVGCIPSKALLHNSHLYHMAHSNDFKNRGIEVDNVRLNLEKFMEQKTNSVKALTGGIAHLFKQNKVTHIKGHGKITSKNEVTALKSDGSSEVVRTKNILIATGSEVTPFAGITVDEDTIVSSTGALSLKKVPEKLVVIGAGVIGLELGSVWSRLGAQVTAVEFLGHIGGMGIDMEISKNFQRILTKQGLKFKLSTKVTGATRSGGTIKVSVEDVKDPSKKEDLDCDVLLVCVGRRPYTENLGLEEMGIQKDQRGRITVNSRFQTNIPNSGASGEVQRQKSILDGSSFLVRIVCVEGIMGGPVHIDYNCVPSVIYTHPEVGFIGKTEEDLKSQGVEYKVGKFPLAANSRAKTNNETDGVVKILADKQTDRILGCHMIGSSAGEIINEAALAMEYGASAEDVARVCHAHPCDMGRCCVPGCRGNYDSGPKVRVFAFPKDEAPKKSWIKAIPRKDFTPSIHSKVCELHFLEADFIRKLSHFDAASGRTLQQRTRSEEQEHRCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPR7</accession>
    <name>A0A9D4PPR7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPR7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029153"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7948290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="243" mass="28116" checksum="0183730EB975A0F7" modified="2023-05-03" version="1">MAGAYIWDDMLRQISAEKLKPLGKLVEPMVWTYVKDVYRFISYSNWATYSEAFEAIWAASAFKGAFGETLTVPNVRMHLENNEGIVVTGWQRYDHFATLCELFPAGLPSLILNLLVLSNGAYSTELLSRFHSLLKCSHSRLIAKPSRRQTTTCHDVTVGKAWITEYNVRRNLTLPTARDVLREVFDEYTVAEWIEQNIYPWVLRLEKLWNDALSIKKTRTWPVRPLEPLPDLRRFNVGESDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PPV7</accession>
    <name>A0A9D4PPV7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PPV7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053124"/>
    <dbReference type="OMA" id="PHEDYEV"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF83">
        <property type="entry name" value="COMPLEMENT FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="159"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7950802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="401" mass="44229" checksum="0BCC81C72A6CBD6C" modified="2023-05-03" version="1">MCPGRRTAATSSLTAAVAATAALAALWLATVQAGSHEGLLRQGNSAWHLTGGPFDNPWISPHPMTAAQPRGKAVDVQTLTNIINVARYILSFPQKCFYRGNAYSCGLGISCWIQGKRPVDLCNGGVIWSCCVPRNAEPSKAGMVKDALCGKTYLRNSKVVGGENAKFGQQPWQAAVVKRSFLSQKISCGGALVHERWVLTAAHCVDRTPASNLRVRLGEHSIRDTAERYPHEEYTVRRKVVNEGFDRRNFKNDIALLELSHPVVFREHIIPICLPSKGENFTGGFATVSGWGRLKYGQSYIPNVLQKVSVEVLENEKCRTWFKDKGRKEQIYDTMLCAGYKDGGRDSCQGDSGGPLTFKKNDRVYLIGLVSWGVQCALPSLPGVYTRVSEYVDWVNIYVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQT2</accession>
    <name>A0A9D4PQT2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQT2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057447"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33177" checksum="2A66D265C6984424" modified="2023-05-03" version="1">MSEVIPSQAEWIQDAAQTFAPQENTVVTKHGLKIEGLVEALETPYVCSNYSYNTVTKTYQAMQALKDTPSSPTPRPSSEGRRDKVDIIFNTSMGVIFGVRKYADALWDVVKGRGITVNMKHELVQVLPNKREAVFRLLDSTANPKETVTFKYNMLHVVPPMTPSAILKTGPSFTDNTGYLDVDGETLQHKRYPNVFGIGDCTNVPTSKTAAAVAGELGILRKNLTNVMKGKAPTKKYNGYTSCPLVTSYDKCILAEFDSKAEPLETFPFNQAKERTSMFYMKRDMLPFIYWNLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PRD4</accession>
    <name>A0A9D4PRD4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_010785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PRD4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048074"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="289"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7951603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="446" mass="49185" checksum="4098FC3F601F18A5" modified="2023-05-03" version="1">MHKKQQRVREVYGAFKLLLFALLRVGINAIPPATFLAVFVQACIYLRLFSLPWFNAEDACIGVSGVLFKGEWQRIFYGAIEHGDSLHLYYNMVSFIWKGINIEEKVGTVQFAWIIFLLTMLTGVLIVCLYYLLAICVDPIFYHHCGIGFSGVIFALKVLDNVVYPTQSRNVLGFPVTLPSGYIVWLELFLIQIMTGNNCGFVGHLGGVLAGFLYIGVITPIFNALWQVFIEAPKSAVRYLCPCLLPVPYGTILLSAASLATNSDFLSSSEMNLKAVGRSSWSSCLIGDGQWRHLLAPVLQCSGRLHLAYTVATLLSLGYRLERKVGTVRFLVDAATLVIVTNVAYSLTTHNLLPQFDQIAGVSTAQMRHASFATPTAILLALKALYGGGRWLRKYPLLFLTVPMPSFVGAILEIGLLQFVLPDLSTVGHTVGFLAGLMMSYVLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PSR2</accession>
    <name>A0A9D4PSR2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PSR2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053448"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="75499" checksum="EC0136D215B5E72E" modified="2023-05-03" version="1">MPRKATGKHMKKTGKDERSLQHQEEISERQNVPAIEDRPLEKAKEALPRSQAISKPPPTTAAPPKPASNTSAPAAPAATAPAAPRNAAKPRLRSSSGTRVSLAAFELDSDPWARETVALLKKQEEEEYQNFEAWLARKRATQRAAIHAAHASTSSAQTPTASPNHLEQQAVTAIGDWLLNKAKEAAPVPAALPEAATIMPVNTDDISSISHAETSVDEAMDTTATSRKRGREEDAAEGPRKQANPHATAAITTTAAAAPAPSPPMRDDAASSTATPAVLLAQAASADNVAAPPAAPAGTRKVNKRKARPKRRRRPRELVYSAAEPRTSPRQLNTMVAVPRPCPSPPPAVDDFVTVVSKAAQRRARALEVAAVATDPAVVGTVLYRPSVPGGSFIRSPRLTLASALAKRPGVLAVRVNHSRNIVAADASTPACLSELLTIRELGGVPVTAREPTDRRASTGYVYGVDGDITDAELLAGITSAVPVLSATREGSTVKLRFAEPLPPELVVLHGLRLRVRHVRPRPSQCQKCGRFRHVAEACTRIGDCLRCGRRHPEADSCKPRCINCGGAHAATNPTCPRWQEERRVATLLATSSTPLSRRAVTAAVREETREVRSYAAAVKTSLLENTTTDRGLQRPTPAPRRSRLPAATSATVAEPADPPTTPAEDPRDALIASLLATLQAVARDLPEEHPLRATCLQAIGARPDASRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PT29</accession>
    <name>A0A9D4PT29_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023474</name>
        <name evidence="3" type="ORF">HPB52_023475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PT29"/>
    <dbReference type="OrthoDB" id="6509227at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7952454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41788" checksum="18B9C196B60A687F" modified="2023-05-03" version="1">MPAYSRPATGAPPVEQLSRKFPKHPPTTAIIGNSQTRYLHRHFNPHDRATPAIITIRGASTFDIEKELASIPRSVTTLVFHVGTSELASYGLDESLRRLRRLVNNTLRTRQELERLVVSCVLPRYPNQRLERSNEQFVHRFNREARQFNETVKAYCRRPSKVSYVDYQFEQLPPRRFLAADGLHPSFMGVALIAETLKSALGRGDLEATTGWSTQPTAPVNIRSSQQNTHDTKPTYQHVPGAPHPPNITAEFPTIGETVTPARPKHPLTIINSAPLLGGKSAGQPRRAPLLRTARPEELHDSTTTPLLKGKPAELRSRVPLLRTPGPELPTNTDILHSTIAGSPMPESSLQRRRPAGHNYNLRTSSVPSPHPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PUE0</accession>
    <name>A0A9D4PUE0_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_005266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PUE0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057988"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7955948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16154" checksum="460C2139CEFDA354" modified="2023-05-03" version="1">MSSAALARRLVRQVAAGVSRRARSSEAAAAGCPFHRALEQTAHRSSSSASKPFSSLPSPKGLPVLGTTLDVLRTGGAPKIHEYCDRRHRELGPIYRETLGSVDAVFVADSALIQKVYTNEGKFPMHMVPDAWLIYNEVKGIQRGLFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVT4</accession>
    <name>A0A9D4PVT4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVT4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="274" mass="29498" checksum="95949AA75C9E121A" modified="2023-05-03" version="1">MPEVEMVEGEAISQEEANAPGWQTALSKNKRSLRQQEGASTQSVGTAGRCTATAQGVVRRLAAASRLPRMPRSHIRVIVRPKGGLDLKKVSLIRLAQALATAANLSPEDTKADIVCPNLTQNILVVSTPESKNAGAYAALCLIRLGSTDYQVSAYTAASDDTCKGIIRGVDVDIDAQQLAAMIVNQRNPKAMEVHRIKDTTTVVILFSGLKVPNYVMCGTSMLRLTFVMGVELSAIVLMFAPLRRRKCAVGVLSTTLRKITNASRNVPCAEEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXB6</accession>
    <name>A0A9D4PXB6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXB6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7956879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="214" mass="24197" checksum="261AA0FE7A98750E" modified="2023-05-03" version="1">MVVTPDTQHVPSVYYGQMLEIDAAVATSDAAAIAVQRGPSEVDSASKKRLENQLGRLTEAVRRQRHAQQQRFDQERRAHESTQRLLKQLLEALASGGFIPSRGHSSRICKILRSEQYRQVRLYRQVMTTSLRCTSDAVGSNSRIRAFSRFVDQTTEWLWQLQLKQLRSRLAGKKPMQKSPAHGAAQLDLPGFVQDALSLGPMFAVEKKRPQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PXR9</accession>
    <name>A0A9D4PXR9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_020736</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PXR9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_058012"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16744">
        <property type="entry name" value="RING-HC_RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7957598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="193" mass="20867" checksum="7F2B1E956F5AFEDC" modified="2023-05-03" version="1">MLKLNGGMVVTSENPKGASASSSNDEGGSTSGQQDGSFECNICLDTAKDAVVSLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGGSKQDPREKLPPRPPGQRSEPESHPGSFTSFGFGDTGFHMSFGIGAFPFGLFASTFNFGDGRPPPTAMGSQEHRQDQIVSQVFLWVACIFLVWLIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY66</accession>
    <name>A0A9D4PY66_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY66"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7957808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="75" mass="8201" checksum="8E59692FBEE00596" modified="2023-05-03" version="1">MDGNINTGKTWKIIKHLLDPTATKTAAKAEMTKIRHKYKGNIREMVTAPHLSSTPEGGMTAVEAMGKTEEATMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYL0</accession>
    <name>A0A9D4PYL0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_006091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYL0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_038744"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7961248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="364" mass="40426" checksum="06E5D510366B0C0B" modified="2023-05-03" version="1">MVDSLDEAVGSVVRALGEAGMLQDSVIVFSADNGGVPWGYMASRGINWPLRGAKSSPWEGGSRAAAFVWSPLLDKRRRVSEQLMHITDWLPTFYALAGGSTSDLGQLDGLDMWGVLSRDEPSQRSDVVYNIDPLWDYAAIRRDNFKIVVGSRGGGKFDQRFPIPGGQRPSPNLEELMERSLAAQTHSKTLNFNPMLHCMLPRVDFTDMKDYLVRETSFVSREQLKAYKSMHGHNYLTSGWVQQPGVKVLQDSTIVAVGKALRALYGKQDLGFAPDWRANTSLSCLGEQCGDQSCFQSADNVFLFDMDKDPCECNNLASTHKQVLDSMNKVLEEYRAQTVPPIKPAVDPASFPENHDGTWAPWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZK3</accession>
    <name>A0A9D4PZK3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZK3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041032"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7961641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="235" mass="25693" checksum="8A0CDBECCD95EAE7" modified="2023-05-03" version="1">MSYYHNFRNTPKSEPTPLCLKRLQLDLAELHADPPPGVFAAPEEDDVTMLHAVIVGSWDTPLEGGLFQVLLKCPRDYPMQPPHACFLTGAQNGVSFSDDIHWGRICLSTLGTGPGPNWSPAQTIGSLLVSIQSLLSDGAAERMRHNTISIALCDTLEGCLKEPPDSNAIPPPLKKQVLKYFVDNYAKYEDSVKARISSSSATFSGSRANGGYELLLQRLRDIKKKVDEKVAADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZM6</accession>
    <name>A0A9D4PZM6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HPB52_011301</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Rsan-2018</strain>
            <tissue evidence="24">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZM6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_032898"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="21">
        <location>
            <begin position="37"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="185"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="457"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="23">
        <location>
            <begin position="563"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="18">
        <location>
            <begin position="673"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="1037"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH7961689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127602" checksum="66E0B0C50B984D1C" modified="2023-05-03" version="1">MDAFVEFPEKPSLKKTLSNDFGKLSSKQHKVIQDVSKAHVESFNYVLREGLSRAVADIPPCEFALPNGDRVKLEIRDPYIGSPMISKNTIGVVTPQVYPAECRNRGTTYRGKLDVTVVWSLNGVHQDTVKKTVGEVPIMVKSQVCNIAKMSPAELVKRGEEAGEFGGYFVVNGNEKIIRMLIMTRRNYPIAMVRPSWKNRGKMFSEYGVSLRSVKPDQTGTNMVLHYLTNGTVQVMFSYMKELFFMPVMMLLKALCDVSDHHIYSELIAGKEEDSFFKGCIINMLRQVQNEGLLTRDQVRAYIGEKFRICMRLPEWYSDEEVAAFLLRHCICVHTESNVDKFNLILLMIRKLFAVAKGECAIESADNPMNHEILLAGHLYLMVLKEKLSGFLYSIRQNIEKKAKSTGSAFKLSMANFSRALATSWDLTSAMNYFLATGNVVTKTGLGLMQFTGTTVIAEKLNYWRYLSHFRCVHRGAFFAEMRTTTVRKLLPEAWGFLCPVHTPDGAPCGLLNHMTALAEVVNQQFPTSHLPSLLVGLGMAPLDGIRPNVAESYVVVLDGRVLGYVEDSSVENLVTSLRTMKACGLEKASVPQTLEVGFVPKTRQASQYPGVFLFTSVARMMRPVLNMQTNTIEWIGTFEQVHLSICVVPDEAYEGITTHQELRQTSMLSLLANMIPYSDFNQSPRNMYQCQMGKQTMGTPCQALRYRSDNKLYRIQTPQTPLVRPTAYDHYDMDEYPTGTNAIVAVISYTGYDMEDAMVLNKSSVERGFKHGSIYKSEVVNLRVLAGDVGRQVSLVFGRKMTDRHLEGHIDLDGLPYIGTKVEHNQPVCSFINIVTGETKVHKYKNMEAGYIHEVKLLGNDTGTDVLQAVCITYWIQRNPMIGDKFASRHGQKGVCSLLLPVENMPFTESGMTPDIIFNPHGFPSRMTIGMMIESMAGKSSMLHGVAHDATPFKFSEDQPASEYFGELLQKAGYNYYGTERMYSGVDGRELEADIFFGVVYYQRLRHMVADKYQVRTTGPVDTLTHQPVKGRKRAGGIRFGEMERDSLLAHGASFLLQDRLFNCSDKSLAYVCSKCQSMLSPVVDKAESDVVRKWKCPTCQTSDFIEIISIPYVFRYLVAELAAMNIGVKLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q053</accession>
    <name>A0A9D4Q053_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q053"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048391"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038811141" evidence="1">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="380" mass="41823" checksum="6C1CC80E5F5C7F08" modified="2023-05-03" version="1">MLPVVHALLSVFTINNVAHAEDLPAQRSSSMNGLCEVTDLEFDVGSHSLNAHGAVASTNTCAKLKPAWGIEDGTPEAKMDSLLCDQVFEIGYFLKFQAHQPPGMFLRDVVIPLFTALSRNASSEAADDQGVVLPAIERVDSGVIDWDTNFFLESSRIKNQLIQAIARGCNVLPLDKRLSAVNKTLCFRKAYFGVPELVDQEAANALLAFVERVKETLAVHTPRPDPKHQPRIGLALPLLHLTTNHVLPDYRRTIAKKISSFAKAVEIDYSRLSLKEQVMQTQDLDVVLVAGSDMISLSSALYLPPWGVVVRFNKETSGKKKEDPFEHLLESRGVLLTTTASMEAGRSLNDVPVFGDNTISDIEHILRKAVAIVQHNLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0G3</accession>
    <name>A0A9D4Q0G3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_014530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0G3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047196"/>
    <dbReference type="OMA" id="RSIANFC"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038997459" description="legumain" evidence="9">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="335"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7962124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="438" mass="49068" checksum="CEACB4C00C3EEAE1" modified="2023-05-03" version="1">MALWWRIFLGLAALASTFAATSKKSTKYVYDGQPKLWALLVAGSKGYDNYRHQADICHAYHVLHNHGVPDERIVVMMYDDIAHSRENPTPGVIINHPNGTDVYRGVPKDYTGDLVTPQNFLDILQGKKVKGGSGKVIASGPKDHVFLYFADHGAPGLLAFPNGVLHAQPFMNVIKSLNKKTFAEMAIYIEACESGSMFDGLLTAYVSVYATTAANPYESSYACYWDKKKGAYLGDLYSVSWLEDSDKKDLQKETLLDQFNIVKKRTSASHVMQYGNLRIGNLSLSEFQGKKKTSPIVLPKAPDDAVSSRDVPIAILRNKLERASTPQEIKSLKDKLRRALRHRLFLKNKVAEIASFVARGKSNDAEVVLTSTRPFTKFYCYEKAVSHFNERCFDISKNPYALQHLRVLMNMCELSYNILDITEAMDLLCTHPPLEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q181</accession>
    <name>A0A9D4Q181_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q181"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042107"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48257:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="542" mass="59552" checksum="F7D719F005B93754" modified="2023-05-03" version="1">MFFAVCYCGASATSFEQQCGAVVYPAALRVADGSNRGTTAASVSTSTTVPTVHGELFPCLTQPENTTPAYVSASPPVEIGQLLTPQPESTTQGTTQKRKRTPSSASLSHEQPEHSNEGPAKSLDSDDSNGVSELAKNLVQTKQVEADLAAESAGTFNVTPTGMVYAKRSLKTQTPFRLYPSTYFVQRKRWREKERALKAKNERLSRTVDAYKQELLKLKEAAHVNDERLDWLEHAFIAYVEDLRDASKAENFFSKETCHALLFTTQSNVACIRHLLTDKKFKFVLTRKMSSDPIEAMFGFLRRSAGCDDALDVRSTICGLEKMLKTGIIAASSGSNVQSSATFTSTQLLPIQQVRCTSTPTAADLILNTAAMRLREHLLSNKPILSNPDIASLAMIGGFIVRAVSERIACAECIAMLQAPNSSAPNHGLITHQDRGGLYYPTQELVKVLVGLRRFADCVLSQRRSVKKPLEACVQRSVQELMSLPVLSCGNTDSDHRKVLLELIARKLIKPLFSNYAQGKTDTNATVKFLEKKPLSRKILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1D4</accession>
    <name>A0A9D4Q1D4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1D4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="14677" checksum="4979FFB9B9D865FE" modified="2023-05-03" version="1">MQQTPSSSRNASQKPELTPVHRASRRIRGLAPEIVPRCTTSTSTGMEDTTALTPDAIPAAAAAAAGAPAYYTLQKPRAFTPSSEPRRVSYADALRRTVPSSVTPPPVSGFQHASYADTFGHISPATVPLSAAAPHSARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q1V9</accession>
    <name>A0A9D4Q1V9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q1V9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7962972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="285" mass="31056" checksum="45BCDAFF84ACA7A8" modified="2023-05-03" version="1">MSILVASSFAVPAAFTVVLAAYVYPQLFMTALAPRTSKRALSEVLNKCISAATGVGLAHWFVRMVPLARTMVDKSALVVQVPIADYMTAAGVLFAHVMNTMFLAVNNGVSVHETSERTVERYVLGTRQYTYDVRPLSSVIYTKLGLLASIHFFVEGFNIGSSVFGTVGLFFSTVTSQIAIALVLGVMGLRTGCGVWKILKMAVLYSSTTPLGIMCGLATEDNAGWMSYMTLAIIVSLMAGCYLAVYMEHIALREISLMSEGKGNRCLFFFTPVLFLICLYSMYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3H0</accession>
    <name>A0A9D4Q3H0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_020933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7963400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3H0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044581"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038781914" description="Granulins domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7963400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="213" mass="22566" checksum="63622E7BD3273B62" modified="2023-05-03" version="1">MLLLTLGFLLLATSTALTADYKRCPDGSLCHKTGTCCLLPVGRYSCCILTNAVCCSARSSCCPEHYICDEASNLCAPAAAAREHSEPRNATTTTAKAASKRTVSARELHMTKCPAGETYCFRDNSTCCRQETGSYGCCPDKDAVCCSDLVNCCPRGFACIRGTGNCVQTASFAKLGAAAGARRTALHARLEGSDIEEPLTVAAMPLERGRMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5V4</accession>
    <name>A0A9D4Q5V4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_009554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5V4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7968542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="17010" checksum="D05FDF262FBDEEB2" modified="2023-05-03" version="1">MDDGNGKRKRKTITIEQKAAMLKAIESGVKKKKVAQDFGVAGGESEDIGAAANEGAAGDQDLASWDALLDAGVVPDCDTFCTYMYVSTDADAVTSEELTEAKIVRAVTGVVNDDSDECVDNSPELTNPMFRRPRKRWMRQTCCAASSALTMTMRTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q7I5</accession>
    <name>A0A9D4Q7I5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HPB52_021947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Rsan-2018</strain>
            <tissue evidence="13">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q7I5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050617"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF30">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7969789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="102" mass="11597" checksum="3DBE7D0802AD5E17" modified="2023-05-03" version="1">MNKSSSSRFQLLEQNRFQDILKIKTIGSSYMAASGLSKEDEPKDGASIQERWGHLAQLTDFALALKDTLNNINRESFNNFVLKMGPSHDEPHWQKKALEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q8I3</accession>
    <name>A0A9D4Q8I3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_002815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q8I3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031807"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7971800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="288" mass="32233" checksum="762A4992CD6D66F5" modified="2023-05-03" version="1">MSKNTVRLLCSQMAHLLEHRTAGGLSVEDQVFCALRFFATGSFQSSVGSEATIRMSQSSISRCIALVTQAIVDVGKLRGWVAFPRTAFERAAVCYSDMKILSIGPRFAGSCHDGHVWRNSGLRKRFMSGRIVVRDGEFLLGDSAYPLEPWLLTPVPGHPDEDTPEGVYNKEHAVLRSTVERCIGLLKSRFRCLQRYRALHYGPRKAGTIVAACASLHNLCLEEPEESDGDEEDDEPAAHTSRTVAPPRRRALYLRGRATRARQIAQLNISRSVHLQRIQRALLRARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9D7</accession>
    <name>A0A9D4Q9D7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_007844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9D7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037477"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="138"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="257" mass="28466" checksum="9A94B1B71CB31088" modified="2023-05-03" version="1">MAYFDMSWSDLEDLFLVVPWEPRPHAYKCESGLINEPLKQLTEGLRVPQVVRSAQGVAVPGEETLLVTATLAPLFGRNSSTISSIVSQVMAHIDRVLGHLLDDLTTHTWLTLDDLNVFCQGSAVHNRGPPLSNCWGFVDGTSRPICHPSVDQRTYFSGHKRVRALKYQAVMGANGIVRELDGPYPGSRHDAGILRESGLNSKLQRLTHGCLYCNDGDPAYPLRPLLMRPYEGAALTEQQQLLNEGMSAVRQAVQWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q9E5</accession>
    <name>A0A9D4Q9E5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_021711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q9E5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="388" mass="43171" checksum="80CE7E1E9D616869" modified="2023-05-03" version="1">MQYAYAWKVTPGSFLIARERHPGTLQEGIAAPFDTITCFVLRLVCQLTAPRRPDALQARRDSLLAANDACVSELRRYDVWRRVWRGLRVNCLRTTMSRDRKDDRKLLEHGPNEDVPTHNKQQGDTSGENKDKNEGAAEPAARKKEATEGDKATAKKNVPEETARPVRTDQIGPHRHGVRASGRKRPLEVDEGNDNGAASACEPLLKAPFVRRPTLRIQPKVPPDRRSAPSTEKRHRQQNHHSGENTWASPEKARPLQEERQETEDKQQVTPSGENKDKNEGAAEPAARKKEATEGDKATAKKNVPEETSQTSADGPDKDPTDMEYAQVVVKRPLEVDEGNDNGASSACEPLPKAPFVRRPTLRIQPKVPPDRRSAPSTEKKAPPAEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QA90</accession>
    <name>A0A9D4QA90_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QA90"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056000"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057892"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="570" mass="62482" checksum="F614B9A06BA6B02E" modified="2023-05-03" version="1">MSTIIWLEDDFGRPGGFEQYFGKPYNESDGGCYAEWEWSCLQMFNRGSEAAVAIGNYVAASEIFALVGRALTSYNPVRNVLSISVAALRPPYYYGEATSTMFYGGLGFIYAEGIFRAVDMMTHLLNGGAVMAPSESAVTSSFWNLSWYSDVREAERTFPWLPALDVAYTSYLRFKDEASDLRLKGLSEYSPTQVFFATFCHGTCWTDSLKRKFSKMCTDATRNFGPFAGAFSCPSNATVREYAGTKKASRVEPPPAAASDVEPHGASHSSDRHSDKASRSSDSLRAAQGAAKPPLLHRRQSSTVPVPLKPNEYNDLSSTSRRRGAVRRQQRTSEVVPPYSPGDQEPVTASFVGVTSADATSSVPEQPGKPQRSSATSPATCSGSPSQASSTSRTAKEESAVLASDVDKTMDAPVMPAGRRRTGGTDEMPLVEGMVRAEKDTAKQNSQNLSNFRFFQIPRVRVHECGKTRQLSQRRQREWIARLNRKGVADNPQKYKGHSLQWVLLALQGLFGSRTALTSAPNRGFFIVDDAKSISAILGLTSNFLMCVGIHELALSVHERSCRTHTPYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QAN7</accession>
    <name>A0A9D4QAN7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QAN7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056706"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="121"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="314" mass="34828" checksum="B34E7B08462AFE79" modified="2023-05-03" version="1">MWLFQVDRVAAVISPVMAEGFLTGCAVMVIVSQLPSVFGSGAKTSKDLFGTPLVIIATAVSHFLQLDTKHNVKVVGNITSGYSVKLVTQRPADRNRDDVKHSRKLYAQWLQSDGPRMCRFYLDETNYNIWCSRNFGRAAKGQPAVHTTTTTKGANLNIMACMSANGVIHWTAVDRVHWAVFDDFLSDVSACVESEEPNTEAVFIFDGAPAHARAEQAALANSMHSIKHLPACSPFFNPIEEVFSKFKSHVKAYLSERPDLVLATPQGMTKKEHRRSLLLDAARHSMQQIQCVDCAAFDRHNFSFVPAALREDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QBQ2</accession>
    <name>A0A9D4QBQ2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_011068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QBQ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033479"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039321"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7972309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1235" mass="132099" checksum="0DB92D6E0F76FFD8" modified="2023-05-03" version="1">MRWFSGNMLQAIAEAHSRRVLLLVFIEGDDLASQNMRSTFDDAEVNKLIDVMGCVPIRLRANSNACRQFTLVYPVTAIPSTFFISSRGNLEASIVGFTDPVLFGDRLAALMASCNLKKVDSEMRNASEASLSVDRMMRLNRQSSTARLPTSAEGGPGPLSQQPPPTEGAIKKRSKGGERRSKKRLRRQEANVQTSIVVLAEQATQINMDDKRSYNSLLQKLAAMEETTSVPTATVATAKVHGELAGDLASLMGDGKEKRDLGVPQESEGALAGGADVDQKGKPLTGNKSEHAVDNGANDQALPGSHKTKGDDEINASMRPPPPPPPPPPPPAAEAVRANKDQGPVNDVPPVALDDADSILCDVIADGPGLLIKFAVLAQEFADKVLGSSQHEHTDGKSLEASAAETPKADVRRPAKSSHRPKAKQEAAKSETSPPAKTVEIHAMKDRQRQPADSFKRACQLESLQANVGDAPEAIATLQEEEALEQVGDKDNSADKRTRSSGTRSHKQQRNSDASLQSPQQQAKHGSEKRKKHRDSTAKDHTGDSKKTTASPKKVTAKAAVAPGSSTQEPDNNLGQLALKIKHFESVAGGASQDPKVLSEKKAKRPKSASPSKPPPPPANDTRARSPENNGSPITQMSSAPPPLPTVSLEQEVCVMRMRPGIDTITEEETGAIESCLTTPQPTPPPPPPLPPTPEVPTQPDVQKVPEEMSHKSSVKEPACETMPAPLSGSQPPSKQTTQATTAQNRKSHQSRKSARRPSSPNRSKEFLTASNSQLEDPIVFGPTHRTSDDSAAAASKRAPLSHSRPRGDRRVATAARSPPYERLVDSDGDDETVDDELMARRTPSSFRVEADWMDEMARTASRRTLLYRAGALEESLNNLFRTLNDMEGPTISLSVGGQSRTSVTKAQAKAAKDDGAVSAPPVGSPSKQHVAISDHKADGVEDDDEAKVNAVGTAAASTKTTHRVSLSGTNVRNLSRSRPSASRLGVNGGRCPSAETSQTSGGGNNARRSSSFTPLAIRGCGGAACGADKVSIVLNLPDGNSVLRSFPASAYLDEVRWYTEELLARVIPTCFPFTMARTNPLREFSREDYRKTLEQLHLVPSAALLVLPSNPETVRALSTRVASRRSAAMGESGAPPLVPSGANGDPFWYSIFRLVFGMFVATPLALFWNLVCPENEPSMTAAREAFLSGSLGSSTLSALPRSGVATAVTPLRSASSSRLCRRRQSSHTENFDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QC98</accession>
    <name>A0A9D4QC98_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin-related protein 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monothiol glutaredoxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_006167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QC98"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037772"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045638"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="349" mass="39900" checksum="7A3574CA735ADC68" modified="2023-05-03" version="1">MGGIERQCYLCSVFECPDQALGHILSPYVRQLVSGQMRELNVNRGKPNRDRKHLSKTYYEVLGVKNDCTQKEVRDAYVKLCKQLHPDVKGPATSIKDHSKFTELNQAYTTLSKPLDRKHYDDTLLHPELQNVQHTVWRQTYARYGSSNDMKKKMQEISQKNWADYHQSRQDFKTYGMEGQLERLLNVRREKQEDKDDKSSEDREYRLGLATTVAMLRSPVRLLSTAAPIADKIANLIKQDKVVVFMKGVPEQPRCGFSNAVVQVLRMHGVDYSAHDVLQDEALRQGIKDFSNWPTIPQVYIDGQFVGGCDIVLQLHQSGELVDELAKVGIKSLLVDSGSSTTDEKQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QCN5</accession>
    <name>A0A9D4QCN5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_006868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QCN5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039515"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7975965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="126" mass="14469" checksum="430E10BCB27BB659" modified="2023-05-03" version="1">MHRDYTFTEEDEDSDENIPDSWEEVESSSRNTWRKEIEGQPQRTPSEGHTNKKDKEPGGSFPSQQGMGKNSEEKEEEANDPDNTTAENSKISQTLRKMSKIDRSFMKTLLSLAGGAEDRRHYWTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QDT6</accession>
    <name>A0A9D4QDT6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_000595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QDT6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_047956"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7975334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="158" mass="17790" checksum="AEFF3A8224C72BBC" modified="2023-05-03" version="1">MLPGLVESERVGIYVYAYASPGHIDFVLDQLLTSAGVDVLPLPDISFDVDNQHNWTFAGYVEFHLQNGTLVNLRRRVRRIGDCGLRGDQENGAPFVELWCNLNLRGVVAHYDVEVIVDDRSNTVVAELLVDTGNIYFKLEARQDNCTECTPRCNSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEA2</accession>
    <name>A0A9D4QEA2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_009612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEA2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053552"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7976200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="251" mass="26153" checksum="F8C9E46D1E72F45D" modified="2023-05-03" version="1">MLATPESPPMNQSMVMREAQCIVHRLEALATTPLVDTRQVTLVDFTLSSSELNMTGSPCCKLFHEETPKKNDTLLENELILAEEQLGALSLSTSTPLQLSPSAPVFGASFTIGTADATGLEPCKDLSPCSLPCPAGTECKAASPKAFLHKALLSDQEDAPSSPCLVTLDEALELRGAGGGLVDVLAGSAPHQSPSLAAGETGLRASDRATDGPCHLFNVAGSDDGNLNSELLLLSYGPSFAHLLTLNAEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QEH8</accession>
    <name>A0A9D4QEH8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_011006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QEH8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040553"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045366"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7976289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67035" checksum="8544FB41241DFEF1" modified="2023-05-03" version="1">MTSYKQTVQNFLMQCAERQQPGSSNPLVFLMMACSDAKYLDGKTAATCTRRLKLDPDPELQDVKDALLGTGFRDELHQALRDPVTLDNTTAVPTEYRRPTYAEALKRPASSPPLFVHAPPTVSLQSAQQLQYCEDTRTSPPFVYADYRRKAYIGVLSTPSSSRANGDRVAATQSNIASAEAPQGPVSTPRYRSVALPTLQVPTYAGDLRQWQEFWDHYSATIHNNIELPPIEKFNALEGLGVPPEQYTVVLHRVLMRCLPEDLAIMYRQKKKEESTRGTNASAEPTPPEARTHKATDILAFLKIQVEVREEGKQAAPSLHPCHSTMVPDDMNSPTRSAHAIPPASALVATESLQQRTLSCVLCNSRAHSLAECTAEMSVEEKKARLRYSRCCYRCGTRNHVAQFCRVSRNFTCNKCRRRHLTVLCELSRAVATTASPRTTEQLVTSGTTPPTVTMASTGEKGAKKHDAADLFDPETWHPDDISILIGSDAYWKFATGSIDRLSEGLTAVETSFGWTVQGTSSPHEAATTCALLMSAGVECDESARWRLGTISIDNWMPKKTQELDMLEHCLSRHAGCYQEPSMITEPLFAFVPPPPLLPTPGHHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4QG12</accession>
    <name>A0A9D4QG12_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7981823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4QG12"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031047"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_040522"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7981823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="428" mass="48192" checksum="0E7A5ACA0B8B4E0E" modified="2023-05-03" version="1">MNRLFFQPHQAGMSKVEAAAKTLQFINPDVEFDTYNYNITTVENFQHFMDTIKTGSLQGGPVDLVLSCVDNFEARMAINTACNELNQVWIESGVSENAVSGHIQLVVPGETACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGIVAGFLVQNTLKYLLKFGTVSHYLGYNALQDFFPTMQMKPNSQCDDSFCIQRQKEYQVREAAKPPPEPVEEQKEEVVHEDNEWAGKPSLDHTHEDSSIILDSAEEQMSDDVDYIPQNIKVDPLEGFNLKRGETGVFEVEELVDILREEKLSDIAVITVPKEMAYADYLVLATAISPRQARGVTEFLRKLYKRKKDSTDPNLVIEGEESADWKVLDMGNVVLHVFLAEARKHYDVETLWTVGSRYDDLSHAKDDPVYNLLQQQIQLMQEMQPKDLNDRCALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SM91</accession>
    <name>A0A9D4SM91_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_003638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7935073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SM91"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7935073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15572" checksum="2BE918174D971E04" modified="2023-05-03" version="1">MAAVMSSHAVWEGIVPNTWEELAEAHLTRRSNQALTHWPDVLRRTGYATIQEPDGERKGNIPSLLRDGWRFSGSPAICIPNITEDGGSTKVKQRQGTTTAMIRRRDTWTLQSMRDVAPSQFASETTRGRHLSTATVLANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNG8</accession>
    <name>A0A9D4SNG8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_000158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNG8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_034557"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050654"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="10">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="10">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="9">
        <location>
            <begin position="134"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="9">
        <location>
            <begin position="294"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7938739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="597" mass="68643" checksum="00142D188B0E2A12" modified="2023-05-03" version="1">MAFPKIKIKPGEKPIFPDMKAFESDSVEIEVVGKAPGKKKLSKLRSPFPYDKKLIPDENEFYNAEFVRQRERMYLITNKDTFFSQAMRSRMTWEGPFGKGRFNRAKETYSERRVLYAEWGRARCWYKEQPLFLIRRYFGEKVGLYFAWVGFYTTMLILPAFVGIFTSLYGLAYMLTNKPTPIYLDNVLVIAATIFIEFWKRQQVVLAWEWNLSNVDTLTEVVNPEYEAKAKVYKLNPVTLLVVVLCTVMGVIGYRIIMVTFLSSKWSRLTAHVATTVSASMINLMVILSLNKCEGGCLYEVFVQLATVMLGQQAIRTTHNVVVPIFKAWWRQRRRRLGKEIVETKSQLARWEEDFNLEDCPKLAPFDEYLEMTIQFGFVTLFVAAFPLAPLFALINNVCEIRLDAYRYSKRLRRPVAERVPNIGAWQAILRLLARCAVICNAFLIAFTSEFIPRLVYQVRHSKGLSLSGYVNFTMATFDTSDYDDAHRPNNGTLHGAIVRECRYVGFREPPGTENEYQLSETFWVITTAQLCFVVIFEHVVFFITGVVAGMIPAMPKSVAQRMKREQIVVQDLIAKLQDTDTAASVAAAHKAQLMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SNZ7</accession>
    <name>A0A9D4SNZ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SNZ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="153" mass="16228" checksum="F3F6253794D1F98D" modified="2023-05-03" version="1">MSSRIEAAELEPHARVHSKRYPLFKMKLSSVLTLVAIFLGLVRPYSPDEEDVLVADVGVSSLPSTGLSHVTSSAPTMQQQRADNSSKTQGATPKDSPLHDASASQWEVVPADNGDPMDVQSSGGPVKRGPPVNVLQQDVIASEQPAKKHPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SP88</accession>
    <name>A0A9D4SP88_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_014764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SP88"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037974"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23638" checksum="8240666133E9D438" modified="2023-05-03" version="1">MQNGEQLQLQRQQTSDPVTALFPPPRALDTTGDVWQSWKTRRQEFELFAKAMYLNQQPKKAQAATFLVFIGEGARKTHTTLILQLTKRIASPQLQPVGAHNDDGESAPKKRAIVRDQPALRPEELDDIKSTLSAIKESLRFLGESMALVQSTLAAHGNRLGQVEHYLDHIVAPAVAAGQPVSQRTTTPSSLPHAALLHPSDHTPSRGETAAPHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPN4</accession>
    <name>A0A9D4SPN4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_020557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPN4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028862"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038995788" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7940044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="164" mass="15618" checksum="1619EAEB90261370" modified="2023-05-03" version="1">MHPSKTQAFAAAVCALLVCGVYADKKDEKVEARGGLLGAGLGGYGAGAGLGGVGLGGYGGGFQSGYGNAAGGHQSGFRGGAAGHQQGSGAFAGGASNRNVNAYNDNKGYSHSSGFSSSDSNSFGAGNKQGSSGYQGGAAGQQGGFGQQSFGHNAGSGYGGGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SPZ7</accession>
    <name>A0A9D4SPZ7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SPZ7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="311" mass="32337" checksum="AABA93F2821C9691" modified="2023-05-03" version="1">MFCIAVATAAAAGKLSARGSFVLNGAAVPVAQVGPQVVTVTVFRCPLFVGDASLAVAFAQYGKVLEIYEQTFKGRQHVGNSLRVVRLGMSKPVPNIMSLQGHRVMCDYRGVTKVCSRCAQEGHVGKDCHTPRCARCETFGHDTTGCSAPCRRCAGEHATADCLQPRSYAAAVGERPAARGQAVATEGESRGQDMAAPDEAREVQARETDSSPEEACVRDWSTWADDASSSLPAERGTAVSTDAESLSGLSQVASTESESSGASTSHSAKASLSRSPSGAESAPSKPPTVKHTGSQVATGRGHRTHVGGFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQC9</accession>
    <name>A0A9D4SQC9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQC9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043706"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046906"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72140" checksum="31EB042A6DA07452" modified="2023-05-03" version="1">MIPEGHSYAVYGFSENLDWSTLNFVKPVDDIRVSCWNRGNGCETIIDVSSIADHFHRDCAYHCTCCPNCSSTVLRRDIIADLESNCTNYVLNRMSRTLPCEDVSKDAQWLREDLHALESTFRNASQNDASLLSSLQGIAAKNRGNQIPIATMADEVELLSQVMRQTQSEVERSSERRVNQSVELRNFREWLCAELDEIERAAIEEWSCERVTLHENKECEEHVDNLEWLQREQGTISRNLEVKNKARSEDVSKNVECLRESVRALESEQVDGLEWLQREVQSLSNKLEEVKNKTSHEAGLRKRAAEDTFMETGLYNTVQEIIEAQRSNQLLRLSRTPTGRNLLRTLRLEPSGTTRNEEAWSPIPIKVAAHMHLKPLPRNMNPQRHPGRRKARADYYIRWYRNRDDVLYVDAAGVALALAVAHAAADSTIAEICTDSPSAYRYFRQGIAPNTVPRILRNIPSLPHPVTITWVPGHECIPGNERVNAHVRGLSIRTLEDHSLKPVTKPEEGICTYHQITSYYRNGRRDLPAPHYSLTPNQSSVWRQLQTKIFISPYLAHLFYPGLHHPHCTTCGAPRADLFHCLWSCPKPLVVDPIPNRSLSSWEATLRATGSDYQLRLVNRACLETSARGLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SQD5</accession>
    <name>A0A9D4SQD5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_015530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SQD5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71384" checksum="0221A6EEB52B8F93" modified="2023-05-03" version="1">MPLEVGSVASHAVLDDNNHDPQRRQRLGSLPLLCTVSNSENQQTTPTMLSDTEETLTATDKAATIGSSTDHNTASIPTAERTNDPQLGEGMDEDSAAFNTVTDATEDDAYNGACWKVVRNKRRARNAAALEAASLLKTDSENPLTKPRPSGTTRLPPLPFQDEKVVLRPLGGLRLDKWPKPTLATALWAAAGVSPSDRKNVILRTRPEQNLAVISTPSSHVADALLQVQELSLGQRTYPVSSYLAAPDDSCKGIVPGLEPGTTSHTLVEEMQATGIQILQARMMGHTNIALVTFEGLRVPRFVRFLGAELRCYPHRPRHPVCKTCLKLGHRADHCPTPDLIICEQCGIDNPMPSHPCSPRCKSCGGDHATTDPKCPRRQRQSFNRSWVKKAIDDERRQMTASTDAAPSSATTHAPETSKKSGRSRSKTRSRARSKTRTKSKSRSRSRSQSTSARIQEKRPTTPASQASPSPYKKALLSKPATSTATPEHQQPRASDNSNAMAAPREVSFEQGPAQLTPPHPPHHNTFRPSPPPNTSTDPFPEIARLRRDMEARHAQMHAQLDAAIESTNARIQAAIDNVRQESLALRKEIIAVIQASEERTHSLFAELVSRFDSVAPLPNTQAMRPQPPLTGARRTHPYSRPTTSSHDDDGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRA5</accession>
    <name>A0A9D4SRA5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRA5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037616"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF254">
        <property type="entry name" value="PROTEIN AMN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7940012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="500" mass="55623" checksum="7DE32B5BF36DD205" modified="2023-05-03" version="1">MIGTLIRTAIVRTARSSRPIVVPVTRTSVRHSGGHGQWVYRQATEPDPYDCKMAEVIMTVMWWWFFYHIITEPEQITVLHAKSIEADLAESPVTGAAIVHVRKCTQLEKLTFSSVPSDNSLCETSLLETVRCFHNLRWLELSGVSAVTDTVLAAIAEQNKLLTVLKLNECVNFGDGGLKALGRNCRFLQCVDFSSTQITTRGLDALANSPCRHTIEEFLANRCSKLEAKAVEILMTNFPSLRILSLEDCRQILFGQQRSRACGKMSPAKVPWVHTLGGREGIAASPCFYQQGFFICPSIVNTAFVMDTLVNEQIKRKAQPLESLPVEDNVSVECHEDTKSMNTQTTNNDHQRASRYLSTISRLRSQVSYHRSKGNGALTEETFQALLFTTQSTVETTRFLLQEGVSYVLTKKLNSDPIEALFGRIRQMCGGNDQLDARAVTAALDRIVKAKSLCPKEAETPDVDAEQVAATLSEKFHDELEDLTQCHAPTPRSVTYSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRL1</accession>
    <name>A0A9D4SRL1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_004014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRL1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050790"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="30654" checksum="18B85AC908B7C72C" modified="2023-05-03" version="1">MSTKRRLVPELWEQLVIDIVDRQAWKVESFDNLTSLESYCEDVRHYPVENERIRMKQRREAALRLRSNPERWSRLALDALRELAADSPGPAVATLAQSGLLGAFKDFAVHTRYFKVTKNIMESAGVTVFVAGHASSSTHDIDKLDPIMLVGYSERWEDRKDTALWHTCLASHYSLNTHHQQHELWHAEDSDDKERECWKALPELLCDKSSRCLQKELNGVVSPDMWTVQTQFYLGMPEVWLDRVTRMAEQLAERTPSRESNVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SRT8</accession>
    <name>A0A9D4SRT8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine methyl ester synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SRT8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051823"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21582" checksum="D86BA88FF5F615AD" modified="2023-05-03" version="1">MLRAHERGVKTQVVHNASILTAVGCCGLQLYNFGETVSIVMWTDTWRPHSYYDKIAANRKRGLHTLCLLDIKMKEKSIENLIKGRDIYEPPRFMTVAEAASQLLEILQVKKSEGVPASELAYDEDSACVGLARVGMETQQITCCSLKDMSSCDLGSPLHSLVIPGKLHPMEMDMLRLFATNRTWFDTVCKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SSJ7</accession>
    <name>A0A9D4SSJ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_006208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SSJ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_033067"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="583"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7946950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="656" mass="72174" checksum="D5E40BB215DA415B" modified="2023-05-03" version="1">MARQRPRSATTASCNSTPCQDSHLEERKSDKPDATACRSFYDFVCSRHNHARPLLHQQAMLMLASQVNASLSSFPALSETLLRGPCPGHYALLGLDFHRACMGPAAAADRQQVERLLRSLGLSGWPLARARPLDRSPSDLAGLLDLRLGVFPIVRLSLRRHYGRITMQLDRTLLPLRLHQLSLPMKDVGSYVRTVERALSLLQGAAPKYEGGTTPYWGAAAAAIVELEQALERAQPRDAFVYGARLIALGDLPRSRQWNWAEYLAIVRDDSTLLSLANLTLLVHEPEQLALATETLGNTSAAVLFNYLGYRALVHLAPLLPADAKFLLQLAPWADAAPPQLAGCLRLLAHLHPFAFHFFAALEPGQTQYAPPKPGDGADALFIAAQRATAAVVETLPWRDNGLGLRRARTLLQARLARGGAPSPENCPRGPSLYPAKDGFLDALLKVQSARPNAFWIMDSPDDGLDSRHQDEPFSMNADYFADPNVVYVSPTLSLALKQRPLGDVQAAAPIVEALLRSVLPGEPNELIRTPPSMLRCLARRLGTTPYDSHMPDLLRELLQPSALLQMTTRANASPLPTVLIKGKQLLTKPQMFFVHWAMTLCDSPHLQKRLRRYKLLSTKHRIDVTLTNHAAFQKAFPCPSGTAMHRSKACPPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4STP3</accession>
    <name>A0A9D4STP3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_018964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4STP3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030388"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7948180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="115" mass="12633" checksum="C14E0AC028D97F15" modified="2023-05-03" version="1">MYNRDLGIASIDSVPAVFGNSVEFLRELVRSVVREELQRQRLDHSAPAVSSLADVVREEVRMAVRDPQPIRGPQQYAQTEAPPQRPQRSSYADALLQGPPARMDIAATSHAPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUC8</accession>
    <name>A0A9D4SUC8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_006041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUC8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039293"/>
    <dbReference type="OMA" id="RRHFQME"/>
    <dbReference type="OrthoDB" id="161999at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17057">
        <property type="entry name" value="Ubl_TMUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040352">
        <property type="entry name" value="TMUB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF5">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="338" mass="36323" checksum="83ACDF87EAD55BCC" modified="2023-05-03" version="1">MSEASATLIEGIGDEVLVFASISFTLVAGLLVVVYVQSVFRPRSGAQDQSTRQDVSSAQNGSARVMASAPSGGDRASPRQTELAPGDSEAATSDSSASRDRGDESRPLQPECEERSAEEELSPDVVRQRRLDFIERSSRVESISGVEPVEPDSGEDSAHSTEEAAREEEEEGFAIRLKYLNDTERCVRGKPDETVGSFKRRHFAAELAGQRLVRLIYNGGQLRDDNARLSSCGLSDGCVVHVHISTAPVVQNETSSANSNGEGDLNLGALMWPLFAATLGILWVLHFQYRELFNTSSTVVLVGISGLFCVGLYGQHYPQSPATADQGGGTRTTPLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUE7</accession>
    <name>A0A9D4SUE7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HPB52_011765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Rsan-2018</strain>
            <tissue evidence="18">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUE7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044783"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="38"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="408"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7951729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="528" mass="57904" checksum="4FAD8BC8072F83C6" modified="2023-05-03" version="1">MAEVAEAPRPQAMYAVHANTLLEHLSSLDINQPTAFVRLTGIICTIGPACQSVKMLVNMMKAGMNIARCNFSHGTHEYHAQTMKNIREAERLLNEEIKPDSRRIAIALDTKGPEIRTGILTGASGTAKEIELKKGAKITVTTDKAFYDKCDENNLYIDYENMPKVLKVGSTIYIDDGLMSLSVNEIDGNKLHCTIDNGGMLGSMKGVNLPGAQVDLPAVSERDKQDLLFGVEQGVDMIFASFMRNANGVREMRKVLGEKGKDIKIMCKIENDEGVHKFDEILEVTDGIMVARGDLGINIPAEKVFLAQKMMIAKCQMLGKPVICATQMLESMTHLPRPTRAEASDVANAVLDGADCVMLSGETAKGDYPIEVVNMMHKICVEAESAFYQKDVFIHLSHIAPSPTDGTHTIAIAAVTASIKCLAAAIVVITTTGRTAHLIAKYRPRCPIIAISRMEQTVRQAHLYRGILPFIYQGERQADWPADVDARIEYALEIGKIRGFLRKDDAVIVVTGWRKGAGATNTLRVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SUP9</accession>
    <name>A0A9D4SUP9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_010265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SUP9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7951518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="859" mass="95351" checksum="756632D5DAA5C5B1" modified="2023-05-03" version="1">MLNLTLAKSWWRKTNSHSRQAVPSSDSSFSDHWQVGLSRRLRPELPIATTLPATVTASDATVSTVTMDTDASAQAAALKAPGKRLPSQTAMDLHSEHDSVPNAKRACTTPSLRSEKQTPTPYKAVIKARACVDLSTLPSKCVQAALDACLQTTGFRGFSIHRQTNTVSVWLPSLDAVRRLQQLKQIVPSVGQPVPVQAYLASGVDLRRYVVAGVDPREDQDTLRRELFCPQHTIVAARHMGKSGTCLVTVQGPLAAPEKMYYYGCVLRPRPFKPAVIFCYGCYRKGHMKASCPNTQSDADMDATAGSNFRCGLCKCDDHDITSPQCPTKRNATRELRHKRQQSSHLGGASVLHLNNSFEILADLEPDDSHITEATSFAEKKSYSAAVKEPRKKLSPTNSALPASQMETPDDLVSLDTRLARLQQEIDNLRRRRELLAKRAASSSTPQHDTNVQPIQQPRSSSADLTPMELLQFVAKQLMSLTQLLNDVTIPTRRADQPHASSYSPDLSWWLGSGAIGWQREPDCWGSDHYPIFLEFPTHGHSRLRRCCRVVHWDAFREAALIPQDQSPQDLQDFLRKALDSATKTSWVDESRPAPDLQLLRLWAARRRAELAAVRDPTSIEAKIQMRNIAAQARRHERRLDRGRWLDWCASLGPSSRTASVWRTFRAMEKGQRQPDPTASEEAQLNTIDELIYQRRQARELKPSFLPPAADLAAYMGNPVSVSPPSIVSLPPWDHRQLTDNKPIGRLRNPVPRPTTTFRRHIEEADAALPTGSLVAYTDASCTDTQVVTSIVVPGHQNLCVNRLYLLRAPVPSVSAELLAIRDATKLVSAASASSSSFTIIRTDSTSAIKELRKVIYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV49</accession>
    <name>A0A9D4SV49_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_016400</name>
        <name evidence="2" type="ORF">HPB52_021151</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV49"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043955"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="168" mass="19035" checksum="630B74FBFFAEB7B0" modified="2023-05-03" version="1">MNASGALRSLESFLPRRGYTYMLRGFNSPFLERRVVTFVSVLKSYYVCVICEAVAAKVWPLSCFHIVCDFCRNSLIGNLTESVLSDGEALDETVLSRHCAVCPADSAPFKLDNLYIEPGDLSFLECELVLCLHADSGCRFVGQLRYLEYHYYNDCPFVPRIGYRSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SV85</accession>
    <name>A0A9D4SV85_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_023597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7948508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SV85"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029195"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="96"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7948508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26394" checksum="4B40C46212D003F8" modified="2023-05-03" version="1">MFYDPAFETAHTERVKIKRDGRIRTRKREPSPSNTGSHAHEDDSCAIASATGGNEMEACGPKADEPPASENVSLSEPVEETTSLLSGNHHEELESSDTPQSKVCDLIVDKMRIRQRLLYHKQRDTFVGDMDMGPELEQLAPTSGEYLVNSLLCFLLCGLYAKFKIPLFSAAATGAHGYLKDQAGHICDLDFASAGPTTEFMKMMQKWFTLMDVSKTRYWASWFFISQKILRTQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVL8</accession>
    <name>A0A9D4SVL8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_003885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7955792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVL8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_043403"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048575"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7955792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="917" mass="101038" checksum="0A1D04F7ADB07419" modified="2023-05-03" version="1">MQTGSATAGSEHRERGRPRFRARPPPLPKRKPLPKLPPADYKVIIRPQTAASLLHHGATELFKAVCAAAQVNPTEVVAEDQLRLHPTNNTALISTPSLDRAGRYIKLQVVKIGQQEIEVFAYAPAPENSTKGILYHACSDEDDAAILNELRARNKGIDIVGARRLGKSRHILTIFAGADRPPYVRYWGATYVVYPFRDRIEACYNCRKVGHRTDVCPQQRQARCKRCGDETHATPEWGTKPTCLARCIVCKGGHPTGGRNCKFKYYSQVQQHNNNSKNSTWTKGTTVVIGQQQGGDQENTTRITSATQPNSQSTGYRDAVRGTPLTEASQARQENATVLQQAPSGSREHSSSRGRAAAHGHYTSHGHGTSQGQGTTRSDPGGEVSETLLQDAEEFTTDALAEEDDPRPDAKLITLLENQQTLQAEWLKRKHDRQLKPALAQAETEVQKYSQELRSAQWMQLCNRLNVLSAVIGVLILLIILVGGQKKDDVKKEPSETTKEKETVLNKEVRAVPKKKKVQEKKRDLKTQYLHPWLMTTLKGHSGSILDLDFNGNGKYLATSADGRSAQRAVQGQNNHSCHKSSSVGGRTTTTASRGPPSPLEGAWRLPLCADDLYHQLLRYRLTPQELYRCGYPRPCPDEPGRAVWLQADAATADSSRKTCCRCGSSFVITPGGEYYANDVCTFHTGRRGLAEFSCCGATGDEPGCERSDYHVCAQGARGERDGPARGFVRTRPRHGVAGGVYALDCEMCFTIRGLEVAKVSVVGSNGATVYDSYVRPGSPVLDYNTAFSGVTAEHLRNVRTTLQDVQAVLLRLFTASTVLVGHGLENDLRGLKILHDTVVDTAVVFPHHRGLPFRRSLRSLVGAYLNRDVQDGPRGHDSVEDARACMELMLWKAGRDQKLRERRSRGAGGRLMQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SVX4</accession>
    <name>A0A9D4SVX4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HPB52_008010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Rsan-2018</strain>
            <tissue evidence="16">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SVX4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048503"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7951337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="400" mass="44239" checksum="A19BF9BD49CE2790" modified="2023-05-03" version="1">MLRRWLRAIGREDLQPKTHHRVCSQHFTASCFYAGLDRACLRPDAVPTEFSGCHEWARNNAKKNVSPATSPVVESVASPPHGRATRAATKVQQAADQAARQPKTKNIGTNTTLLPRKDAPTQARAANSEGQPLPKKRLFNLRLEAKGQSESQVKGSKDASTSQPAHVEKPKLVTVNGSKSEEDSGWDNMSNCSDDLEEHADAVEQTVNRDLDSGEPGPVTTATGALFLHTYCGERIEPEEVVKPKLLLQVAKRRLTLVERKLKRKSEAYNELLDANKELKFELSLAQRPKQQQFSVSDRLPQELLRDWHENAGRVPHARRYTATTLRFAADLHACSRTAYEHVAHWLPMPTLYLVRRHSAMSSRGDGSQESGGVVAATTPSRKGENTSAGPRDTTVPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWC3</accession>
    <name>A0A9D4SWC3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWC3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_039571"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7951801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="458" mass="47244" checksum="8B2AD3E7827E8407" modified="2023-05-03" version="1">MQRLFRHIHGADCVTPADVSLASLPSSLPPSPYSPSPSSSSSSSSSFPLPHSLYGATAAGASPLFGAGDTSPPLFMPLPFPLPPSPHRPYEPWTRTPPGVSPYLAAAAAAAAGTVPPPPPPSTTFAGAPSVPAHTTAPLHLAAAAAAARLPRPIPTTTMSAAAAAAAAATSPSRYDSVASLSGSIPAATGVDAVVTATAAAVAATTSVAQASSTVNSYSQSMYAYDRNAAAAAAAAAAAAGMSLHFDHHGHHPGIPLSSYAPSLLWVRSEQYTLVLDAFSRTCDTAASLTPHRRSLTGGRGKRDPAFRRDGRRNKHGTPSLTIIKPLLCCCETPRSPQTIILRLGTQLNLAKYPTYQVTNAIGVAAGLTASEVRDVNIQVRTLQNLVAATSGRESATQKLAGLRSLTLNGKRHDVTAYVAAEAHHARCVVHGLPRIFLTTSFSASSASKTGRFWQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWG3</accession>
    <name>A0A9D4SWG3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_010631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWG3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7956557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="181" mass="19989" checksum="292E85B1053E2D26" modified="2023-05-03" version="1">MGKKDNDAYWYMCETKDSIRVLMVLYAFVTFLALVAEATSTVVTARNTDYHRRPYVWIMGATYTSLRFLTLIVIIYWIVAATRTNVRGMRMAFNIVFVRVIGNLIYNGAYFVTEVFLIASRVTSPVVLSPTTPRLPSRGDVSRVASPPAVTSPRKGAKARPSGSVAPSRVASPTVAYAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SWR5</accession>
    <name>A0A9D4SWR5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_020126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SWR5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7952206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="105" mass="10980" checksum="632AABA35A42BB00" modified="2023-05-03" version="1">MDTKKVSVGLEIRVEDGRLTLGPGLSLDAQWYGGSQRVATQLVDASNLPTSALPSAAVGAALALDAASQTAASAGEAAITTSLRRIVREAPFGVALKDWMRYIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4SYV5</accession>
    <name>A0A9D4SYV5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4SYV5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036879"/>
    <dbReference type="OMA" id="MATRCCD"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7957293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18262" checksum="D0DDE7AAA43271E9" modified="2023-05-03" version="1">MAFIDVFVGFPGSVHDARVLQEIFVYEVGVYEVASKCEGGYVLGDAAYTLLPWLLPPYRPIANWQPWMTRFNKVHSKQRVVVECAFGILKARFQRLLYIGVTDIEQAVRIVIGACVLHNVARRSGDTVDEGEVADTGTDVSSTDPIDDQTPAVSAAAMRDTLAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T2A2</accession>
    <name>A0A9D4T2A2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T2A2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052471"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7968880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="351" mass="40025" checksum="D4F47E1522FAA910" modified="2023-05-03" version="1">METRFACRNPDRHMMSGMGDSSDNEEVRNEFAVPEGSGSHSEMEVLKMKIKLRELELEIVREQRGSRPSSRVDRGQENHSELRHFSKLISSVPPKFPMEAEVPVWFEAAESALEGYEVPKAWWGQIIFPLVAEKISFLSTRLAPPQQRNYEVLKGAVLEEMKLLTREYLRQFHGAKKKSGRRVARVRDQVAELYLHCYVEARGVSTFEELLELFTVDQMKDGLSDAALKYVTLHEGGGQHKAHEIAALDITFQEAEGENSGVKRLERKIETMTTGPQDRAKPPVREPTKTRGRFLCGVHGHLKADCLRAENRDAAKSGSQERIWSVHAHVDDGYNCRRVRTRAHQATLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T326</accession>
    <name>A0A9D4T326_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_020919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7969660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T326"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7969660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="10996" checksum="1CAA766F0E81FA40" modified="2023-05-03" version="1">MPAGITFEGFADADIDLELCAELTDDEIIRQVTEDSDDSDTENEEPAPTQPTSSELMRALMTLSSVYSGNMTLTEIEADMIVGKRNTVQKKISNFFAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4M0</accession>
    <name>A0A9D4T4M0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HPB52_016626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Rsan-2018</strain>
            <tissue evidence="9">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4M0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037635"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7972751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41173" checksum="6ED93982FB5D46B6" modified="2023-05-03" version="1">MSTDLTSAISTFTIDLYRQLLSDSCGETANIVVSPFSIAAALSMTLAGAKGNTATEITKVLHTSGDLIHGQFSEFFARVSTYAPDVMLDVANRLYSEKTFVVLEDYLATLKKFYDSTVVPVNFKTEAEAARVAINAWVEEATKSKIKDLLPNGVVDSDTALVLVNAIYFKGLWKDQFNPKVTCLQEFHTSKESSKEVDMMYKQSRFGINTTCTDLNANAIEIPYRGGKTSMVIVLPHEVDGLAKLEVALTPSKLSDILNGFHYKTVALSLPRFRIEYSVNLKQTLRSMGVKDLFSNNANLSGINGKRDLTVSAAVHKAFVEVNEEGTEAAAATAMVIMKKCAVMAIPFCVDHPFMFFIRSHDPDVILFAGSVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T4P5</accession>
    <name>A0A9D4T4P5_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-asparaginase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T4P5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_037696"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044933"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7972826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="470" mass="52459" checksum="E983FBB7ABA2EA01" modified="2023-05-03" version="1">MSSDAEQELRSSDSRSSSPPLEARTNGHSEGSPSRQDMRSSRSLLDTSYAPKVLRKTSDCLVSQEPPSHCNESKVLVLYSGGTIGMVRDCEGGVLRPMPQVMENRLRTFPQLHDTEYSSTRFTDPNKPPLVLPCTGDPNRVVYTIYEYDPLLDSSNATMDDWVRIALDIRAYYEQFDGFVVLHGTDTMAYTASALSFMLENLGKSVIITVTLRCFVQIPIFEPRSDGRENLLNSLIIAGNYVIPEVTLMFNNKLFRGNRTSKTSINELDAFSSPNLPPLATIGVKIKVNWRAVFQQNTMEKFRVHSKLNRNVGLLRLFPSITVEVTAIPPRYPRVLQGGSGGGFDGAQGPRRGFGVRPPFHGNDDTSSRDYGHTRYGDCRDDAVDGPHYLPDRTQQGRPQWRQRGRSVTPPMKPGAWKENWRSARLKAHAILTNAEAAGSREVSTPGLARATARPIEEEDTLREIRAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5A3</accession>
    <name>A0A9D4T5A3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tick transposon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_003472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7971849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5A3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046315"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7971849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33842" checksum="90C667EF01AEE62B" modified="2023-05-03" version="1">MDKFDCHGGLVYDEMKLSENINVKVSGELTGFVDLGPFTDGSTNTARGIDRSGTSLASKRRIFALPRTSRVGPTLAETNQLPLSLRAKAGALRHIHRMHQTLQGQHGHQATLSPQLPHALEYAALVPEMPHCDWLPIPPHRDRGLAISTIVPGVRCKKRTPQCALQETAAVIDEHLSGRVLVYTDGSVTAEGSAAAACVAPTLEVTGKCRLPFAASSTTAELAALDLADDILVEFLPPAAAVLCDSRAGLLALARGERGALIAQRLFRKFTVIQNSGCDLVFHSIGEPSACTSEDWPQQTGASVSPPSTHRMQPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T5R1</accession>
    <name>A0A9D4T5R1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T5R1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_025724"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7972465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19128" checksum="F9E0D830193B0240" modified="2023-05-03" version="1">MDRLRRCRGVVQAAATKLITSATEALQAENPSPTNQGVLLDDLQDKDTTLGDLSQKIADITTDSAEYGEEVTMTLDYHNIRNAMSRVRYLLKSAARPTDGAAPGVATETRRQGVSSQANTDREQRRELSFEVPTKIQPRGTGAKTSCLTIAGTVSVSAGRRICKQQPCLLPTLWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T658</accession>
    <name>A0A9D4T658_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein O-mannosyl-transferase 2</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein twisted</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HPB52_019055</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Rsan-2018</strain>
            <tissue evidence="21">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with Rt/POMT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7972930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T658"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029728"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23282">
        <property type="entry name" value="beta-trefoil_MIR_POMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000026">
        <property type="entry name" value="Blast:Protein O-mannosyl-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="359"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="420"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH7972930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="701" mass="80161" checksum="AE4FDB5F70C23C53" modified="2023-05-03" version="1">MTAKTAKKKADALSTEPDGDRRKSAAGYFDDLARDHLRTVFLVIVLLSLGTRLYKITEPDHVCWDETHFGKMGSWYINRTFFFDVHPPLGKMLIALAGKLTGYNGTFPFGKPGDKYEDHNYAGMRIFCALLGSMVPPFCFVIVWELSHSLPAAVLASSLVIFDVGLVTLSQYILLDPILMFFIVGAFMSIVVFKAQENSVKFVGLFVVLLVGFYTVYDLWELLGDLEKPLVLVGKHFVSRALCLIALPMCLYMLYFYVHLHVLYKSGSGDGFFSSEFQSRLKGNSLYRASMPREVAYGAQITLKNHRTGGAYLHSHWHLYPEGLGARQQQVTTYSHKDDNNNWIIKKYDQEPNPKNKTVELVRNGDLIRLEHVVTTRNLHSHKEPAPVTKRHYQVTCYGENGTGDANDVWKVEVVGGTPGEVVQTVTSKLKLIHYLTGCALHSHNKQLPKWGYEQMEVTCHPNLRDKNILWNVEDNHYPHLPNVSFEAYAPGFLKMFMESHAVMLQGNAGLKPKEGEVTSRPWQWPINYKGQFFSGVQYRIYLLGNPVIWWGNLVCMALYGFIQLYVLVRQKRGYMGSPETEERDRRLTRSAVWLVVGWALHYLPFYGMGRVLYFHHYFPALIFSSMLSGVVLDYILRVVPTFLPEKIRLSAHHWIMGCYLSVILYSFYLFSPLAYGMDGSISVHENSTMHGLRWLDTWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6J9</accession>
    <name>A0A9D4T6J9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001247">
        <property type="protein sequence ID" value="KAH7973244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6J9"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031200"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7973244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="188" mass="20263" checksum="F0B01CD907299276" modified="2023-05-03" version="1">MVPHLTNAATPPAQPATSSVSSGSGRTSPSSSSASPNDPGSIDDTSVAALDDDNSSSADDAPTTELPADNTALLGEQARLLCSLLRELPTPDAWTQIEAAWSQAFALAAEAVRLPPLRPDHQHRPHNANNAADIQRLYTRNRRRAVRLILEGPSRQCDIPLQELHDYRVREVRGYHATISPDACPSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T6V3</accession>
    <name>A0A9D4T6V3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_002332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7975504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T6V3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042585"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7975504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35683" checksum="C88730D19887B6FF" modified="2023-05-03" version="1">MTRPYPSTLVTTPLLRSFDTRAKFAALQTCATSDHLRPIYVFSHMTNSLEEFEDFLAQGVNAIEADISFAPNGTVTNFYHGPGCDSARNCERKTDAGTYFNHVKRTVSAENGRHRDKMLLLYVDIKPSNLPGKKTMYAAGVSLAEKLMRHLWSGVPPNRMVNVLLSVFCVSEVEVFRGALHTLSKAANHADLLEHVGFDVSGNNFLSSIALAFKKLGVTRHRWQGDGTTNPYIDVYPTARMSWVTARRTSNGSVRNYVDKAYVWTADHTFTIRRFLRKKIDGIVSNSPGNVLEILKSAEFSSKYRLANSLDNPWKRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7E6</accession>
    <name>A0A9D4T7E6_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase greatwall</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microtubule-associated serine/threonine-protein kinase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_009610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7E6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026617"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="159"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7976198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="318" mass="35888" checksum="BDBDB15F3AA38EAC" modified="2023-05-03" version="1">MQQKKLAAAKVVTTLFPRIPKVTTLLLEFFVKREDVLLTTREPLSEFCQQEVVLAAQGLLDKLNRQIITFQDVRDTAENMIGLHNLVYKKSPEIAKELGDNVRKMIVIVGELATSLEQVSDVPPTDWMGIGDTIVAKTADLNMAEIAPFWSYIPKMADFQSVKLLGAGGFGAVYKALYKPTSLLTSIKIVPREKFQMNKQACADKLTASVIKNPFLVKYYTVFCTRDAYLTVMEYICGADLNRVVDKAVYLPTKECRIVMAQLILALEHMHLRGLIHRDIKVSNMMIVPGGRVKVIDLDTNKVCVGHCKYYLFCHFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T7S1</accession>
    <name>A0A9D4T7S1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_017229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T7S1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036898"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_055303"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7976644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="322" mass="36404" checksum="D4BDB20C7CA52BD0" modified="2023-05-03" version="1">MIRALVPGSTSEESSDEEALEAGVYEHVFDVMFRPPDKKPKVEHFVDDVARQYSDEEFRRHFRLSRRVATELIAGFASSPMCPKDNHGGKAAKSAETHILSFIWYAANKTCMRDVADRFNVAASTVHRVLQRVADYLCTLGPTVLTFPRDLEKLSRDFEKVSGVPGVVGCIDGYYIRIQCPENKIASTYVNRHHFLSMTLQAVCDNKRRFSDVLVGSSSKIHDSRVFRLSSLAKKIPGICQGGRYHILGDELLDDSDEEEANDDVPWSKCTDSDECEEEDTEEDAALLKLGELKREKVFQKMLGENEKSANDFLLRIVKVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T876</accession>
    <name>A0A9D4T876_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HPB52_022800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Rsan-2018</strain>
            <tissue evidence="6">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001246">
        <property type="protein sequence ID" value="KAH7976990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T876"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044746"/>
    <dbReference type="OMA" id="RHGFARC"/>
    <dbReference type="OrthoDB" id="7698582at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7976990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="492" mass="55442" checksum="7A9629D00DDB8BFB" modified="2023-05-03" version="1">MSRKRRSLRLDEKLKILKFVDENPTSKRQVLARQLDIPLSTLTTLVGRRGSIEANLQRFGPACRSTRSGRHKNLEDFMCSWMSDAAEAPSMEEMRETAQAVARSMGIDDFTASNGWLWRFKKRHGFARCKQPSLAKQRAAVSSERTRKEPEDLLAFLGAREEYHPRDVYVIGWTQLYYALLPSDLVKPDPDGDLLVTNSAAKVRQRVNVILGVNEDCTDRLAPWVVGRRGSPKNLRNVRNPPCAYLGASTEDLSQTPVDALEQYLVVLDNRMRAEKRVVAVLLTPDLAEAVSCDFKNVRLYSLGGSAMSNQNPLDVGILRRFKQLYRTFLFRRFTVLNDQPEEARPSLLVAMSFILTSWDSLEQNVVRTAFKACGFRGCILSHSAAGELEQDDVAGNEMDTGDVLPDNFDQMDEELAFNEVTVKQEPGVDKTSPSEEPQAGDEGHTERVVTNRDALKALDTLRLYLCQNDCGKEALKAFHALESELYKSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T8U2</accession>
    <name>A0A9D4T8U2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HPB52_007362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Rsan-2018</strain>
            <tissue evidence="12">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="6"/>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7982835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T8U2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_045402"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding oxidoreductase/transferase type 4 C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7982835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="470" mass="50144" checksum="5341716C80C2D25F" modified="2023-05-03" version="1">MNKTVVNGTAIAQQILVELKCSLLTGSNEDALEESLLRFVDKCMSHSHISDGTMAKDSARVKDAGCGAELPTDSDANVDEADRATATGGSSTSAETATPTTAADADTAWDADSSADGRQGQAAGQEPATAVVQGSALAQKEKTIDGWHTAKVEGASTSTDASGERGDVGAAVLAHVPDGGEFVDTQTGYCTGEPEECAKFLEKAMKGEPEDEGVYKEYLDNQKMGDAESPAHEFEGEATEVLWEEAASDAREPSIEGEEVEGPQRRSASVEAENGTAEGAVATGENDEGSDESDDGHSQFDRNRDNHARSHENHGQGSLLSKGPKFNRELWRLRESIGEALRHDGYVYKYDISVPLATYMDVVALVREQVRGTSAIRVCGFGHMGDSNLHLNITAAGWDEALLGRIEPFVYEWTASVRGSISAEHGIGLHKKRFLHLCKTPAALGAMRSLKRAFDPLGILNPYKMLPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9H5</accession>
    <name>A0A9D4T9H5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_010857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9H5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031705"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7983317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="135" mass="14377" checksum="FC5C7C3FAD9F1C68" modified="2023-05-03" version="1">MSTLLGKGPKFSVEALVPAHELAALNRRVAKKAPQEDHDRCLLEGVDCLTKSVSCPSSNRTGSENLAASLETLLVEGQRLRGAAHWRLLAEGAPPLVGEEPQLAEVTYGGTPSLADTESFVSAEGTPDSRRTVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4T9L4</accession>
    <name>A0A9D4T9L4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4T9L4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053295"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7983359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="362" mass="39190" checksum="0EC8F68A88035DDC" modified="2023-05-03" version="1">MEVEVEGEEITQEELTAERGWHTARSRRRDGRGGKNSSPSASPQTQESCSRTIPKKNVKAQVLKAGRMPPLPKNEIKIILRPKGGLHISKVGSPTVTAAIFHATKMPLEESQEDTICPNVQQNIIVISTPHPHNADRYVRLKSIHVNGTTHEVNAYEAAPDNTTKGVIRGIPLTDTAQEIDANVVNTRNPLALAAKHIGTTTTVVIAFDGPSAPRLVRYGATLIPCSLYRKKIDVCYHCGRLGHRMDVCPFPNNKICRGCGSRNPDQDHQCTPKCTLCDGAHPTADKECAAKYKTPSSPNPSPKEEGPPVRSYRAVTAMENNLHTLFPPSAPAAITMDTTDVARGVPALPPAASSIPHHGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TB02</accession>
    <name>A0A9D4TB02_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TB02"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027449"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="247" mass="26885" checksum="EEA3965D3DBB4827" modified="2023-05-03" version="1">MAPTTVAAIAPAAASPGGMQPPGMYPAYLQLASMTPPAVVPPAILPDGNTFCVCLSVVFNPSDFYGQIVEKANPTVKVLEDLQQNLNKFGSQSEAPVEEMVTKGSFWICRFQGDKNWYRAQVLDVLPGPTCQRFRVLYVDYGNRSTVLCSFLRPLPPELASLPACAHRMSLAYVGPKQGNKWDESAIGVFVKETGFNISLIAEKKGHRRAGFEDITEVVLWNRNGPTAVNINVVLVEQDVAVLKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TBW7</accession>
    <name>A0A9D4TBW7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TBW7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="207" mass="22067" checksum="508AEDE4FB689E7E" modified="2023-05-03" version="1">MSWLSKQTIFLKLQADFPCIESCKEKCGFSNGGVDDVVLRKAEAQQLGCSCLCQDVRQCSAEETVEISLVGSASTKLPLSPRTNHAQLVCRITCMDILGMVAHDYALLSFESDGSGGLLRSFLGVDRVKSNHNLSQSLQERLNYSARNSPANLAVPAPPPPTPVEARAFRSSYSARATPGKLGAVAARTVSVGGRGLAAAAPRRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TC75</accession>
    <name>A0A9D4TC75_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_023886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TC75"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046825"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7984767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="525" mass="57592" checksum="DDC0E8D2C97A1563" modified="2023-05-03" version="1">MYAFFGRSPSNTVGGKDPPQLGLFERRGSLRKPLAPDATKEEPFKRSWSFRIGGGGFKTKDVSPGGNDSSAFLRMFRFGEDKKKGSHQEPGRRRMSDAAVTKAARKEELSQCPACQRVARSKTSPGGHSRHAGAHVAALSGGRSLSSCGRTRCRSFWRLPPVAANGGDTNAIRGLIYGDLKAEVNGDLIRIPRTKSSRNHESRSGKVSDAVLPHFLSPGHNLCGGDPERENEKRALKKLLFKRNVPCDGCRSPSNTVGGKDPPQLGLFERRGSLRKPLAPDATKEEPFKRSWSFRIGGGGFKTKDVSPGGNDSSAFLRMFRFGEDKKKGSHQEPGRRRMSDAAVTKAARKEELSQCPACQRVARSKTSPGGHSRHAGAHVAALSGGRSLSSCGRTRCRSFWRLPPVAANGGDTNAIRGLIYGDLKAEVNGDLIRIPRTKSSRNHESRSGKVSDAVLPHFLSPGHNLCGGDPERENEKRALKKLLFKRNVPCDGCVERKRRRRPLRRLRVRRVGGHVRRLWPNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TCK5</accession>
    <name>A0A9D4TCK5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024305</name>
        <name evidence="2" type="ORF">HPB52_025155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001073">
        <property type="protein sequence ID" value="KAH7985134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABSTV010000560">
        <property type="protein sequence ID" value="KAH7986175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TCK5"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7985134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7986175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="79" mass="8378" checksum="77F42000CAFF6B76" modified="2023-05-03" version="1">MPGSARISAGFGVVFLEARLRKRVVVLAGTSPSAPRTTVRWAQTIAGDSDSDGSERLLIELGAQIYDFKCSPRTAALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDT8</accession>
    <name>A0A9D4TDT8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000380">
        <property type="protein sequence ID" value="KAH7986544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDT8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_027017"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_031064"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF27">
        <property type="entry name" value="KELCH REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40993" checksum="E3F7163BC9423278" modified="2023-05-03" version="1">MACGVGFLGGMVYVVGGVTTKKQVFTGMAPAEVLSTVHATDPNERTFTDLVDVLAFDSLRGRWEFRFKLSRPRHAVAAANADDRVYVIGGMTCLEGASVEDVDVYHRQRLCFLDCQCLPRKLTGRVVLHYHVLKNRWDLCGMMPEPRSYHATVLIGNTVYVTDPNDSSRSEAQVSGKGKLWCAPLPCVLVIMGERPVFPGTYSPTDSKCGELVACKTTFAYDIDAMEWSRKADMKTGRRHTGGSFQGQAFRFRRQRTLRTVVRRSAATQTARVPCGGFSRRQAVADRRLLRQLGTGTKPDTNIYVIGGTSSVLNGPIRRPEVYLQQDDRYKFPAEYPEAMTGISAVSVPPVTPTFRSRSLTCMITDALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4TDZ7</accession>
    <name>A0A9D4TDZ7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_024671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000235">
        <property type="protein sequence ID" value="KAH7986864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4TDZ7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035687"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7986864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="275" mass="30738" checksum="B06C090641490842" modified="2023-05-03" version="1">MEDNLAQINNLDHVPLFELLPISGEDTSVVSLDESNEASKLLVSTLGLEGTCMEPLQQSFPKTTEGISQRKPMALEELESVEKMFDSVNQPFHILPNLTEPGNCQVLPNKNCEIGMDTNVVHVYERNENAVAEKAMNSSYVSLPQLINDLNNIGLMITDRPLKSSRYHWLSWKNIRPRRRLESKFDELQQLNPSQFPLGSRHISVPQRVAVPLARGNSVTLPDEPKDPRTVVCLLSGSATFPQFKSKTAVAMAQTIHQKGGGAQLPARRHRSRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YNR7</accession>
    <name>A0A9D4YNR7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_010007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YNR7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7983189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="76" mass="8562" checksum="4BAD22A792DF2E65" modified="2023-05-03" version="1">MTRAEASSLCSDEILVEEIRQRPALYDQRLKSYRDTELQNDASLEFGESDVLSCVMKAEKAFIEAKLAAVATHRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YP90</accession>
    <name>A0A9D4YP90_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_012084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7983442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YP90"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038340358" description="Spaetzle domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="484"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7983442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="575" mass="63867" checksum="C36AFBF75F98CD1B" modified="2023-05-03" version="1">MASVVLLLAVTFAPNFILFSASESDDVLPSVRYREYDSPNIRHDAQSNTPEFVKDLYSLQSIPIPGVDYEFLPVPLKLSADYRNTDSDDGEDKDATVDSVQKISNKGPKVAANNDASSEADDATSELNEETRDSVKRDPPRKPLFDRSDERHDSSLPRFGDGGGQREYESYPSKLPPPSKLRPRFEPQYPDASSYPSRQDVEVPRTGFLGVSHGRLESQPTGSLQGGGRSDERSSKPALEFHFDIPNDKFHSDLAHGRFSTFKEVPSSLDTLVSSDVSFLNKMIADPPVPDNVTRDGSERSYNAGGDRANAVVHVFPSVAQHQPGHRTPSSYQTYPQNEHPAPGRQESSPGSYEDSRSYSQPDSGPRGYSDEREYPYKLPRRRYRAKRSSKTSGNRETRISPDFIKKNANSTEAKVADHGSTLASCSEEEDALPFCLVDPSYPTKEIAMALREDVEFKRIFNHLRAAQKTGGRENGTARSVAAHCPSFVRPVRPLKGRDVLGEWKTIVNIDGFGQELLLNTCSTQNLSCRVKPPKSCVQLFEIQMLALYDERTRKLHSGEFPVPTGCVCGDDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YQZ4</accession>
    <name>A0A9D4YQZ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_023502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001245">
        <property type="protein sequence ID" value="KAH7984673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YQZ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_041425"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7984673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="270" mass="30737" checksum="999EEA6D51EF2275" modified="2023-05-03" version="1">MSVATAKVRRRLGQVKITNWNAFRQDFEEEPIQTIAEWSKGIREAYERATKAVERTDITPEIDNYLLRLWEPRRSMTKRWRRQKGNRKLKRKIAALTIEAEQYAQDLSKQNWNEFCDSLKGTLGTAKTWALLRNMIDPNKSETENNKTLHRIAHNFQGNDAELLGKIRERYIGSVNIAACTDPYRGQAQSITKTYQNRKNAAYVDVATYENGKDAVVTMIDAQLKEKVSASLKNWNVSDAEEAAVALAVAEGKSLGSSPCQDKECVLHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4YRV3</accession>
    <name>A0A9D4YRV3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_024750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010000297">
        <property type="protein sequence ID" value="KAH7986747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4YRV3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_035687"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7986747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="265" mass="30583" checksum="9F316F14526F0A14" modified="2023-05-03" version="1">MPKAKRVARRNSRALCRLHKPAQERFDHTAQKERKGHNSSFDGNVNEMDDKAQVNDQDYVPLFELLPISREDTSMVSLEESDEASKLLVSTFGLEGTCMKPLQQSFPKTTESFSQRKRMPLEELESLEEMFSSMNQPFPTLHKGTELWNCQMLPKMNFDIGMDTNVIHVYENKENVVAEKAMNSSYIRLPHLINDLNIIGLMITDKPLKSSRYRRLSWKSIRPRSRLGSKLDELQQLIASQFLLGSRHISVPNVLPPRGSRMHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PBW0</accession>
    <name>A0A9D4PBW0_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_024249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001307">
        <property type="protein sequence ID" value="KAH7932616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PBW0"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053168"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057785"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7932616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="587" mass="63016" checksum="8A08C62A7588985E" modified="2023-05-03" version="1">METMVDHQAGRGVTLHRPHPGFYSREKESSRGTAAPRARPPPPASGPSSPETHHHPYARKHQDPGPHLLSRSPLLPSLVPPASVRRLPRLSRPAYEGAEELHVTRPTRYAPQSRRRPASATRDVSIDDLIDAVEETAGDDSVLVLQHMGGSKFLVCTRNASQATKLMVAEGFKINREHVAVEAVGPPVTFVNVYRFPAYLPDEVLANALAQYGKVKSVSFATLANRQNKLNGVRVVRIEMSRPVPNFSTIAGHRVMCEYRGMRRVCARCSEPGHMASACTAAYCKRCGVFGHETEGCVEECKRCGGRHGTRECFRKRSYVAAARGFPSETRTTTSATQPGSPRSLTAASSSSGLQVLRPRPRPLMPMNAPDSEVIQASQERNDIRLSPTSPSPPAAGAETNDETRMNQVASNPAPRNPRAPSSEQEVPEDEHAPSDNAATPPGLDDVNFPPLAAATTAPPNLDEAPIVSRGYYPLPDSEHPPPGPLPPAVTQTPGPTSGDPTPAATPMAQSGLVRRDRSRSRSPLRGDTMAATAESSHPPSLDNKHRRPKTHDLSSDSDAPPTAKSQKLGTPPSGKGHPPPGAGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PE71</accession>
    <name>A0A9D4PE71_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_019442</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Rsan-2018</strain>
            <tissue evidence="19">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PE71"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_029284"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049293"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052261"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="488"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="691"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7936171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117762" checksum="A7204A33EF87F6B6" modified="2023-05-03" version="1">MTEIDTQEQPPREEQQHQQQQHEDVVVHNGYSLVSVAATWCAGAILGTLAGVLGFLFVATVATGSLFPSKQRQGPPPPERDDGSVCYSPDCLATAAYLHEKLNPLVEPCRNFPDYVCGRFRGPSSVMEQVLAVHVELSYKYGVSGLLRIQPNVARSLSVELDHEALMASAERVENVTISYLLLLASIAEVKYDVTLLLQWNTLHQSMEQAVAHAWIVSAQSVRAASQAFKQVKDLQFAGVSPNAFADAIEASTPYRREASVYEGRRVVPLLESVWQAFTDIDDLLVWTGWYVLDALAPFVDTLAAKLKSDDKLSFGTSCVTMVSHVMAPAVAALIRLSQVTDKARDQIATMTDVIATCLKGKTTWISPFATPPRLLVGFPPYADSVERLDAFYANFPKSSQNFFADWIAAADERARRLSPDQEHVDVFRMEVDVAADGTVVVPASLFALPFFATGGPPALNVGGLGHLIARRLAERAKRKPDYGTNPPRIVVFPRDQTVVTGQVAVFVCTAIGNPPPQIEWRRNGKRIISRRHTVTEITGGSVLRLYSVRSVKEDATYECLAKNGVGDPARAEFKLTVVEEYQIPRGFPHFKLLPNHQGVERNRSALLPCKAEGDPEPRFSWLRNGIPVDMSSPRYSLAAAGKWTLFCSLHISDAQEEDQGRYECVAENSVGTAISPFANLLVRAVRRVAPYFAIPPESTYEVSPGAALNLTCVAVGSPMPYMRWRKGGVDLTADGEDVVSRSVLVLENVRESANYTCVASSSLGVIEHDSQVIVQEDDDQPQSPTYSQVRDAWADFDNRTDQNATTTSSVLPTDVPLPEDMDVHAPDNLTASVEPPTSTRNSAAVVMPPRVLLLPDTNPFAPLRELEEQNNIEGKSDNASRQARIISTAPNGEKRARGSLLPTPEREYTNVPGDFSHARRASHMLPASAGHQDEDGSWIPVSYRRKQQNRATVAPTPGSGSPRKYPHTVILRPKQPCRIMDEQFMRLDRVITRHISAHLDLSEEDPLPEFTVRYLGRSNQLAVDAAEPEVRNALLAIGSLPLSGKKCPFTHTKRLVKIKSEALFETQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PER1</accession>
    <name>A0A9D4PER1_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_011351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PER1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028642"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7939344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="606" mass="70201" checksum="9E106A84D858863D" modified="2023-05-03" version="1">MVFYILIEAPANNNENQENVQQAAPQQQPAFSYWSVFKGLLFRAAIIYFMTSWFRGQPANQNAGGGSGPPGATPQSSNLYPNGTVMDMYMYISEDSTFNSFHDPEALVWKEPGLVYGDWYGGPNGDSIYTKNMRFRPSEAMKNNGTIFLHVFFVLNGYSPDPKAGKDYSQTHTVYRKKQLNKYKKLRYKRTQNLLTGETAATPEMVEKAEAMKEEILSHWHPNLTVNIIVDHTPWTQGQVPMPVDQHVEFEPTTGKYYPIVYINDYWNLIRDYQAINETTEWLDLQLTFQPLSMFRWQLYVAQGMRSFSFFGQDLMEESEEDKDSLKEAFLETSPYLLAVTVVVSLLHSVFEFLAFKSDIQFWRNRKSLEGLSVRSVFFNVFQSVVVLLYILDNDTNTLVRLSVFVGLLIDIWKIHKVVNITVDRENKLFGMFPRIRMTDKCTYVESSTREYDMMAFKYLSWALFPLLAAYCVYSLMYLEHKSWYSWVLGVMYGFLLTFVAHLPWRMLTYKFLNTFIDDIFAFVIKMPTMYRLGCFRDDIVFLIFLYQRWIYRVDPTRVNEFGTSAVDDTAVEAAAAAEQPNGALPTTEGGDPSTSEKPEELKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PET8</accession>
    <name>A0A9D4PET8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_005224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PET8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22036" checksum="91AA1F4FEE1FECCA" modified="2023-05-03" version="1">MKEIVAGTEITPEGFEASEWLTQVNKSREARTSKGTTIPPASDTQDGRSTSHKTSNASNDDTAATDRSLTPRQRGLRLALNSVASKQPRLPSDALKLIVRPRGGLLLSKITNFILFEAVCTAANFPKSSVRGEDLIQVNPKQNTFAYCTPAVERAERVLRLKELVIGTHTYEISVYCAPDESQARGVIRGVDLRLDRQGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEW7</accession>
    <name>A0A9D4PEW7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HPB52_005870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Rsan-2018</strain>
            <tissue evidence="8">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEW7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036808"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903744">
        <property type="term" value="P:positive regulation of anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22789">
        <property type="entry name" value="BORCS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018780">
        <property type="entry name" value="TBORCS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634:SF2">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10158">
        <property type="entry name" value="LOH1CR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7939107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="227" mass="24883" checksum="9553E4856F13B013" modified="2023-05-03" version="1">MGLEQSSHSSGGSLKVGKGRHAKASSPRPSISSDSDVPYVSSTVNNPIGDSPKLSSKSPAHLLRNSPRPSPKPRPHSYAGTSGHSIVVVKEGSSIPQFWPILKGSLHSPIICDSDVGERLDHRAVNRLASRYQEHLRQCAELVSTEQNALAARIREIDYAVSTLSTMMTERQKKFGKYVEQLLKVHELSNLLQTTESSLAKTIEQLDQLNRLLPPDEQLEPFVMVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PEZ8</accession>
    <name>A0A9D4PEZ8_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PEZ8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="91" mass="9535" checksum="7B529D2BF905C5CF" modified="2023-05-03" version="1">MTTITLGRRGLPVQGMTPASNTGSAVKRPLEKSEGIANDSKAEGPPAKATLERRLGQRTRPNLPIDRAAGKLTDMQQDDAAPQNGTGGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PF61</accession>
    <name>A0A9D4PF61_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001255">
        <property type="protein sequence ID" value="KAH7936298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PF61"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_046933"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7936298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13248" checksum="F945C597174C8779" modified="2023-05-03" version="1">MEPSEVTSERDHLLSNEPCAASVATAQRSLGKNKSCHILNGDSRNMIFHCYTCWRNTEPEHSVADTSKFVADMLGVSERTVFRDGIFDILHAKYIKHVEGALCCIIVGFEGGKWRGSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFD8</accession>
    <name>A0A9D4PFD8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_008047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFD8"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_028265"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7939177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="183" mass="19701" checksum="7E9BCFFDE8EEF995" modified="2023-05-03" version="1">MIEAPIKDGVVSSPYPPVELIQDQALYQHIKKRFLEHCDKPALERNGEFLTFAELLSVIERYAVGFQRYGVSSGRRVCVSVTNSAESIIAAYSLCVLGATVVLVKTTLPELTGSALMLGPLPCLTTVLVASCVVVSVAVDLPPVFIVALVALLLAGSHCTYAVYRFENDATFLLLCSFIAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFJ4</accession>
    <name>A0A9D4PFJ4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_013673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFJ4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044590"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054289"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7939553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="281" mass="31299" checksum="A0B7420F85A731EB" modified="2023-05-03" version="1">MDTPGPVKAIICTVGETATSENMYPSDYCDYLFFTDVYAKGGLIHARKDYRSFIIFVQTAARRSNMEFGISFAFDLVTPNNLDESARFLNVLRREGIRHYGLLTVLNFQGDYNATVSSTRAIITGSHWFAVSAKTKFSNPSIITGLSFELSALKYVMVDDPTSLHESVFLPCLSVKKTGREALCRHSDFTGGPENYLDYPIYAYGVFSNTSKVLTLSEYNDSLATKFLNAVTDFGDLREDTAWLLYNVHNDAPNNQCPEPPFTVLQCFSVALKGGEAPAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PFT7</accession>
    <name>A0A9D4PFT7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran gtpase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_000315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7938780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PFT7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036670"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7938780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="87237" checksum="D64D9EE43ED44EAB" modified="2023-05-03" version="1">MSDPGAGPSRMEDQPAVDKPGEKAPQEGETRSFKQFVDGLVASAYSLFPTADVVRAIFTAADREFVSEKARDRRVSRCCTHIDDYDGVLECWALGQQKGWTRLFGPRGIELVEVDAGTLRFRTLNVNPEDLLAADDAKFLCLCLWLLEQHRCISSVSISVPVVAPRHGLLFLSMLKLTMYVTKLEIMGDNPFKEMSVGDLPDSSTSREPWMHVLKDLCNLRELGLSSMYICETDALVLIDFLERRKASIVAVVLIDVEFSAATFYSLIGAVHKIQRLEDLRIKTSASIHTRTFENALSLLGKSSTLSRLYVHVDFSIRSLLNCLTLSGALAELTLEPMIRSSEDLESLRLSLERRELPLRLKMSLDLSEMHTAHRSMNALLWIVRRSCVRTLILSGSTINLAQSGALAEALESSKLEELHLDECGIECEAVERFASAIAEFLQHSNFKELNVGAVVGDAKQQRQMFRCITEAGVRSKITLVCTECLIQNYHDWDILPNQTHFAKVSLSIGDSSQVERILLNLMAAADTLESFSIKSNGGLSEMGGNCVAELIRTCTKLKVLRLRCRLTSPAAVLILAALAKCRNVRLLTVEGWVIDGVMGQAFETMLTANRSLFRLEFYWKDFAAYQGFKPFLTQGLRENSCVMVLKMYEGERRDELAECDPEILLSLQRNEMALGWATKLVLRDWMKAEGIALADLLDVCEAPLDLYQRVADFSPRTAENRVRLACMNTRSAYYALRDAFPVPVAHVNVADVQDNLHDLIDAMRQMIVRKLQNADVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PGL8</accession>
    <name>A0A9D4PGL8_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_011379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PGL8"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7939349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="184" mass="21102" checksum="3BA394B8761413C5" modified="2023-05-03" version="1">MGALDARFETRGAKRIWRARSHIERVERSRDCRVDFAPLTRPVSCFGYLLPDEEEAGHLNTMGSPHGYRACRRLFDDGEDRATRRTLDKMQEDSSRTWNFDFGRDRPMQGRYQWQRCGDDDKRTSTQWRCWGDASPGSATDPSAQLSTACREGWSYNIQSRLLGVILQSHHSIAWQVPAEGCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PH43</accession>
    <name>A0A9D4PH43_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_017250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7939766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PH43"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_048417"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7939766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="505" mass="56081" checksum="13CDC56311429910" modified="2023-05-03" version="1">MDFFGHSLAKSEAKEFDEQLPGLSRESDNRPNDASSVSQQAESSNEARASSDVSLNNEKDDDEGLSRTWTDDGWHTVLSCRRKKNSNKTPKEPEKGMEKKNEESPGNPSVDGAGESQAKGDFLRRKRRGPPPLPKEDIKVFLRPHKGLTVKNLLVSELSMAVIEACRNTFGGDSILLRVHPGSNIVIMSTPREEVAGRLREISQLKIRGQIHPFNAYAADPEDVLRGIVHGLPPATIQAQAIRYPYKPTVQVCKICRSTGHRTDVCPTPNANVCSKCGASDPNQGHQCTLNCAICGEGHATGDRSVEMPRRKTEWTYAEMEFPQLEQQQQKPPRWFRSDREDAPGKPNLKKTSSSSGEKNSTLAGKGEEEVAAADLTTEDQRANQLNKHHLGYPRDSPKGTRLEHAVSKQGLSLITLPTTPTRDTNWTNLEENLGSDHYIISISFSTPKLRRIIGDVVITDWERFRRRDPPSDSRNGPSQTKAGREILARVGFPPYPQNLDESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PHT4</accession>
    <name>A0A9D4PHT4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_022086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001254">
        <property type="protein sequence ID" value="KAH7940171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PHT4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7940171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="280" mass="30735" checksum="0E1E5CC652358A44" modified="2023-05-03" version="1">MELHATEKKKIFARHWRVCTTWGESCSLIGRPEFRLPDNARRLVKNCSDATMAGGRRKFATAHAYGKKRKRRSRIPKAASSGSTATSSATCASGCTTSTEAAAAQAMPVADDTSRTMRVDTLLVSEAEKVAIEHRAEAQRQKLSSLSATRRKQSLIGDSPEAAGCGTEFTLLSLPLLNQLLRCAKCEFCSGPLNVSRGDLETAVAEAVARFNAGKKRASEAILKDLHLSQGSTDVERCLEKDQWRLAACDKKHTRAENFRNAMKRRRVKENDSDYVPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIR1</accession>
    <name>A0A9D4PIR1_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nlr family card domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_008478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIR1"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_042725"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71376" checksum="F63E71A6868BA620" modified="2023-05-03" version="1">MQAVPLLHYCLTFHRCLVSVDLNGCVLEDHHQLICEALRQSHSIRKLKLHILSAVTLASQSFAATLPHLNQLRDLEFKHVRFDRTFAERLSELLSRTASLTTLTMSYVWTTGEGMLLVLEALKLNETITTLSLDSCFVLTLVKWFPVVFADYLRENRTLRTLSVTSFSKDFQSWLRLMTESLLPNKTLSKLNLVQFRLDIEGINLITEFLRQNQTLRSLNLTSCVWPSSQYGADTYISFGSFGKVSSLIYPWLVALNENKTLEELTVDLSWCNTDECRSLFRALSNNVSLKKLTVEDFGNKDMVEICKAFREAGLQERIFVPRHHVGHGNTVAFNECTELSSIKIDSAMFHGFDQLLKALRLLPSCNHVRSLFLVVSDEMFNATVSSLIGQYITATRALRELELQFQTGVVSRTRNAVGRGERALVQALSGNKSIHRLSIIGLCFDEAETQMLVNMLRSSQTVWDMTFYPGIASSTALLVKNLSPNFARNFTILHMNVTWNVDVYGDCFALARVASRNSSLVTRAAHFVMGGRRKYCAAAIELVHFTPGLVARVQELASVDEDEAVLRIKKSHNRLSELDDFMRMAGVVKDRVTCHRRDDGQMQLVDLNRDCWLYLRRFLKVGDIPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PIR4</accession>
    <name>A0A9D4PIR4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_013451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PIR4"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="99" mass="11188" checksum="4978471D48BBC1EA" modified="2023-05-03" version="1">MGGIEFAHQQARALLHRATLAEYGAENEKGQPLVTYKGIVELYRNERPCFPEPLPEFTRKHQTDTGRNIPAPPEYLTDCTRASTGRNAPCAMNQEHYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PJT2</accession>
    <name>A0A9D4PJT2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PJT2"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7943903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11488" checksum="950F103A910838A6" modified="2023-05-03" version="1">MFAERLKVSPQLLNLCLKARILLDQLSYPGVFPVLWQWYLRYLWWRRRWLRLGSIRQGRYLLESRPGARAPFGASAAPGAAAPAASGRDGTPLPGSTCHAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKA6</accession>
    <name>A0A9D4PKA6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HPB52_018118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Rsan-2018</strain>
            <tissue evidence="11">Larvae</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKA6"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051621"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="424"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7944298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121022" checksum="295209F914424B5C" modified="2023-05-03" version="1">MSRSPEYTHDAHREKRSPSAKSRHRGKKGKGDGSPRRSHSSRRSKKRRSRSKSRKSRSKKFGGDDSLSPAASSEVSSGSRKSRRRKSRKRHKPRRSRGSKRSREGRSRIKSKEGRDKTGGGDLVGRGSKSPDQKSPEGTITVEKRSKSRASKRSGSRRGKSRKRHGKGRRKDKSRSKSSRKSRSSGRSPEVSGSPKRSQESVSPERRSETRASKGSKRSGRSRSRDGRKSGSGSSRKSKSSRHSRRKHGRHSRHGRRRKRRRGKRRGKSRSPRSSGRQSRSRAKRRRRRKHGKRHRTSRKRSHSTRASRERRLHGAKKATEQVGYAGGYTSFCLALAIFAILVLIVCALAAYYACVIKSKSNATSTATSEGTGHTGSSRSTRKHRTRRTPRSTTKPLEPYYCTSGYCKREGQYIGALLSATTSPCDDFYEHVCATWVSQHPERSTFTGSLVSQDTMIQMALTRHLLDQLKGARSGPDVGVAAELHSDCIDRIGSIPPAVDSLGSLFAKWSIVSWPRGDTLHDGEVAVWRFAAELARDLDLATIARVGVSVNPDNLDETVVTLEMPRFLLSEADPAKGDAAELFKRAVGEVVGELKASVAGDFAQRLFTVRSAFAIVKTPSRNGEDELVVRFGKLSEGLREFLTVLLSNVPRRLTSETNVLLRSAAYFQRDVHGVLRSFPLEDTVNYFGFLVIVRLAPFLSHDMRSLRNLFADSVLGHTVGEVAADTPLLCAWLVDRVLPDCVAKAIGRWRHSAGRDVVTREWLDQLEMVFLKHVTDLPWIGELSALLVRYRLKRRATIQVGPSTKLDCARGLRPTGSNPLLVFWNVSKQRQDKTLRGLLMRGDRLRNRVWASGRTDLSVEASFRRDFQLVHVPAALFNDSVPTGSSVFVFHLARVAVRFYRALAQFLHENPYEREAPLSFTQDYGHQLAEILDCLRERALDSGALLSARELLDRTTALLMAVNAFDRLLPIRRIWRLDLRLKELPDVTAHQLFFIYFALDNCESRDPAFHHARLSAKQAVNVPLKHLSQFAEAFKCRPGAPMAGLDCMLDFRRRRSAAEMTWNDQESDHEVAETSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKN5</accession>
    <name>A0A9D4PKN5_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_011993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7943850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKN5"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_050571"/>
    <dbReference type="OrthoDB" id="6499869at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7943850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="565" mass="62686" checksum="5F725D5476E44031" modified="2023-05-03" version="1">MNVRLRANEPLSRLAEQLTDVGGPLSVGELDLTNCIGVDVNQLLPLVAECGLLQRLRCPSCAIPPSNVIRLAMQQLPYLTEVEFSCLVDRNALQAEIKNIVSSKYSPGGGAFTLRRIYCEVGQHHNFVLLLALLHHSPNANDLHVHLVCGDFQKPVEACRGLLATHRQLETFTFTSELPSPIQDEPVPPFDFATLAAVCANISHLRSINFWNCTRLRDLADDSAARRIMLFQTILVAVEDDLTTEWIRLASVKHDWKNVRQLCLVLLPPRPSIFYPAAGGNYRDCLRAFSNALAHVVEINISTFHFEIGLDVTALLQEGSLQFLQSLSAPPCGFRRVSALRRLALHCSDFQELDVRFERRGRFSRCDGCEGNSSLVTEEGTEFRDGASPVFRNGLARLTLSQLHDAACLWFIESCKPMATLRLSYCPLEIHYELLRRPLADSSGPSCLIIQHHVFRLDDTALLANLNRFGQLRHLYLLLETPLSPSAASNAVTAASRSLPHLKCLHAHYQDVVDPNLLGTITWLRGPGGAKGDRVLRGGPCFQSCSTATFIGLAKPLNHDIQPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PKU9</accession>
    <name>A0A9D4PKU9_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_004973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PKU9"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7946848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="67" mass="7408" checksum="364AF478D955ABFF" modified="2023-05-03" version="1">MESEYESSSHIPVPSTLTAAAGPHTEPRMFGVLTNDIRNPNATLKDVEKAAMTWFRHAAERLAAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PL83</accession>
    <name>A0A9D4PL83_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_002226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7946644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PL83"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053144"/>
    <dbReference type="OMA" id="YMPAQMN"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7946644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="264" mass="28358" checksum="E2A5F733D1156A32" modified="2023-05-03" version="1">MSLNTSHAPGGVLVFAGELILIYSDDVEVTFEGTAAKKFQGAKKGRIYLTTHRVVFINKNSKDFLQSFSFPFVNMSNLGLEQPIFGANYIRGNVTAEENGNWMGKCSFKLKFMKGGAIEFGQAMMTASKFAQRAPTVVVVPCQMPAGPYQVLQPTAYLPGQTANVGFFIPTNVFPQVPPANSVYTSNVPPPYPGVYPTNQNPRVSPSNTSASGTARAAEGTARPSSPGFKDRAAQESGQKEENKSPTAPAPRPGFKDPPSRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMM2</accession>
    <name>A0A9D4PMM2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Glutamate receptor ionotropic, kainate 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HPB52_012316</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Rsan-2018</strain>
            <tissue evidence="22">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMM2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_030690"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000061">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="290"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="300"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="599"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7947484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87711" checksum="E95CD6E2368820DE" modified="2023-05-03" version="1">MSACTNLNVPHLQTTWHPTSNRNPYTLNLFPDPDLFGKAFLDLVLNKKWKTFTVLYEDQQSLILLKDVLNNSFAQNHAVSLVQLNPRLSFKKIMKDIGVTKQYNVIVDIKTSSLPALLREAREVNMMTYYHNYIITSLDLHTLDLGEFSDLQANITAFRLVDPQRPEVVNVTDTALMYDAVTLLATGLHNADRVMHNLDLQSLNCNQPKPWKYGSSLLESMKMTTIKGLTGDVRIEHRGIREDFYMDVIELKTKGMIKVATWHPVNGLAYFVNYTQVAEKEFTDKLEGLTLRVTTVESRPYTMLHPEGSNKTGNDRFYGYCIDLIKMLAREIGFKYEFYLTPDGAYGKPQANNEWNGMIRELLDRKADAAIVDLTITYERESAVDFTIPFMSTGISILFKKPEKSDPSLFSFLHPFSVDVWLYMLTAYLAVSLLIFIMGRFTPYEWVSPHPCVPEEGDLQSQFNLPNSFCATSTRIASSMWGCFSLIMVSSYTANLAAFLTAQRMTAPIENANDLAKQTKISYGCLDGGSDISSSHATLLALAQNSDNPLIKRMWTTMNAVRPSAFTKSNKKGVERVKRGDYAYLMEFSSIEYEVERDCNLTAIGGLLDNKGYGIATPPGSPVRSVLSSYIIRLQERGDLEMLKRRWWRVGGKDACPTEKAASATNEMGLSNVGGVFLALIFGCAGAIVTVTFEFFWKINKIPYGERDSVWVELWKELKLVLSCKGSKENPQKTPEDSLSNSIGLSSLHHINYSATSINPTANALLAKAALRGDNKSANKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PMY7</accession>
    <name>A0A9D4PMY7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_021388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001253">
        <property type="protein sequence ID" value="KAH7944571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PMY7"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7944571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18575" checksum="9413F6A0658FA640" modified="2023-05-03" version="1">MASPIPPPLFLPSPGHPPIPWSDWKLIFQAYADAAGKDATKPERLKALLQNALGYAVLKLFCTLNAASASASMTANFLLRGHKALILRSAGRANMAPRLLCFNAAFMARFHSLSAAVEMATPCRQILHFLNNTEVLARVRTFPLIYFPCSSSSCACSGCTCSVCTAFYSVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PNF3</accession>
    <name>A0A9D4PNF3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_016525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PNF3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_049308"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7947889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18068" checksum="D8C45AA3343A3C94" modified="2023-05-03" version="1">MANSVSLLLGLGSGLTLGWLLGAKFGLRNGLSKLLGCAGGVVIRDVGECSGDDSGEFKLVLVVRSDIKMEKGKAAAQCSHAAVLAYKQAQRDAPRSLRQWERQGQRKVVLRASTEDEMLSLASQARAKGLITSLVRDAGRTQLAPGTRTVLGVGPAPEQLVDSVTGHLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PP05</accession>
    <name>A0A9D4PP05_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_011967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001252">
        <property type="protein sequence ID" value="KAH7947441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PP05"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026091"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7947441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="390" mass="41134" checksum="3355848BD9889943" modified="2023-05-03" version="1">MLQRALGHIDRLHRAADGRTLLERLRSQPRSRMGGLCQLYHQMVPDPPVPVARPPPHHRPPEVHLSLDGATKRCTPAAALQQAAACKLQEQLEGRLQVFTDGSVMPDGTAAAACVIPSKAISRQCRLPFPASSTAAELAGLHLAADLLAEDIPAVPIAVLCDSKAALQTLANHRRAGLTGNLLETKFRALTASGASVSFHWLPSHVGIAGDEEADRLSTPARHHLLAGPPEEAPRHNPPGPEGGQRAGTKASPRDGPHQKGTSLPAATADRLCVDRGPPLPEGSLRLPSLQPLRRPRDPRANLYLPRIGKGTLDSHHSLPEAGPSCHYPGAPPLPIPSPSTSAPEPGGFPRGDGNRGLPLRPGPLPPPPPPILAAGLLLFVLMTSVPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQB7</accession>
    <name>A0A9D4PQB7_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7950773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQB7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_053152"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="64"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7950773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="674" mass="74205" checksum="DEE5A1AB213917FD" modified="2023-05-03" version="1">MESSSTSDHRAIIASSSTPRKTYNIVAATTGLVVFAFLAYALTQIVVKLSANKHRTLSLYYGSGLVHGGTLLNVMDRGVVQYLNLRYAKVPERFGPSVPYQAKLIGDEMQDHPQPCVRGAYSAFPSHPFPMSEQFEDCLFLNVWTPLRGKDDDDISPKPVVVVLVGGNFVSGGSGDYELFDGSVMASLWNQVIVIPNYRVGMLGFYTTTGDNTTRDAGLADQVLALDWVRTHISDYGGDPKKVTLFGHEAGATAVGLHLSSPTSSALFHRAILLSGSPYRLMPKHADSIIRDISHDLLCSDEMDAPDTDQHITPCLKIKSIHSLLEHQRSATLGGAVAAFSPSLGKTGVNLDGGSSREELEGKTDGAAFEGRKDILVGTTENEGSAYTNALLGFYGVEHEEDLDRGTAAQILHTYLKHHGIRIDEAILETFLQRDESSSVVRTLSGAIGDFVVHCPLKRFLESYMRGARRRFAPANVYVYYFRHVPDFRWWPYWMGSPQMLDWIYLSGNLQGLRSDKINIGDTEILLSKKLASLLSCFALTGNPEKCTRSPLAHWTKATDSKLRTLVVENATTLEMREGLPFGDACKDWDAVIANSSVGAATTHNSAIRVLNATRIQLQQLQNIRYILTNRKATLPMGERKSEVRGMVPNEYEGYPHHGQYGYASALHDIIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQL4</accession>
    <name>A0A9D4PQL4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_007725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQL4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_054237"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="81" mass="8753" checksum="67A3F113291BC408" modified="2023-05-03" version="1">MCAAQASPRTVQRRYGQTTPPEAAAVVAAGLGGHKRKQLSLAYEELTTVPYSLVEKYTADVEVLDLSHNRLTLKPVDNAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PQN6</accession>
    <name>A0A9D4PQN6_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_006982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7951237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PQN6"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7951237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="450" mass="50301" checksum="7E13C29DC6153A4E" modified="2023-05-03" version="1">MPAPNILAAGGSDWIKYASAMFDAANTYIGLNVTTAAMAALITRLQDALYVSTNALYVGRLPALDYVFPFADMSSWKVILREVPLIGMEDPVNLVGVVKVLLDKHSSVQAAALVYFSVHTANSVFYEEVRHTKQATSLVVQASFCGEQIVKLFSLWDVLSTQQITSPDRDAVVMQLFDSVAEAVVADAQVVFSEYLNSSEVRSVLRGVRVVLAIDMTAPYAHHLPYVSDNYFENVLELRDFHFQVRRINAARGLSGLHFFRKTLFESFVSRVGNHIIISAAVYPLLNFNETRVRGNRSRLNGAAINNAAVLGMLLADALWDALIKSDRWDLQTRQQLYERTLCLKEITGFILVPDMKHPLLSLQSTARAIATPGWHQRVLAFGPYSFSASQIFFMLFVLHHPCQTLRVNDDGFARDVSVFVRFVEEFRGAFGCPAPNLNWAIVCKVNWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PTJ2</accession>
    <name>A0A9D4PTJ2_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_019637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001251">
        <property type="protein sequence ID" value="KAH7952159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PTJ2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_052069"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7952159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12565" checksum="ADE49AE21BC4D361" modified="2023-05-03" version="1">MTCGSGLFQLECFLAQWLSEMQLDGDALSASVLQQAPAEVQLQTRESVLAHLGTVRSCLSSLTTVRMQHLYQLHSSPKYVDRLVDTLQQKLYLADKNLQSREAVATRRQEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PV74</accession>
    <name>A0A9D4PV74_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HPB52_008455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Rsan-2018</strain>
            <tissue evidence="5">Larvae</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PV74"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7956353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="100" mass="11121" checksum="28389CB1147E80EB" modified="2023-05-03" version="1">MGASRKLALWEELTAALNALGPAVKTVKLWRKYWSRLCCDSRKLAREIERERRRTGGGRLGGVEGRVLAILDVTAPDSQPVRLFTGDEVRIIIVAKCLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PVU7</accession>
    <name>A0A9D4PVU7_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HPB52_012361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Rsan-2018</strain>
            <tissue evidence="2">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7956745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PVU7"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_044590"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7956745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="204" mass="23147" checksum="74A1F2A057B27DDA" modified="2023-05-03" version="1">MYPNDDICQYLYYTDVVIVDGKIRPSLERNSWNQFQIMAKAYSKVKSGIAFDHWHVTPQLVHNAKVELDKLARNKIGSYGLLNVIRKPNELKDVVQAMKPVIEETHWPLVNANATYANAETLRGLSFEMGTLIYVLEKDAASLRDGAYAKCVDFGMTTRDVANVPSLIQLDELGRPPPLKKSFPGTGRHSWRWNSRTHKGSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PY84</accession>
    <name>A0A9D4PY84_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HPB52_017976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Rsan-2018</strain>
            <tissue evidence="4">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PY84"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_036368"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056706"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="165"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7957344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="358" mass="40268" checksum="BC1D07A5418B87F1" modified="2023-05-03" version="1">MAGHKRGPRFKDPDEPRRKNSRVSVLERARIVGGYRRDGGLKQLAEALGINIKTARSFAATDRQKSLKGGGSKKKFGDDVVSTLRQIVVENCTFTLRQIKAALEEEMPGVTISTSTVARLLDAHSYSVKLVTQRPADRNRDDVKHSRKLYAQWLQSDGPRVCRFYLDETNYNIWCSRNFGSAAKGQPAVHTITTTKEANLNIMSCVSANGVIHWTAVDRVHWAVFNDFLSDVSARVESEEPNTEAVFIFDGAPAHARVEQAALANSVHSIQRLPAYSPFFNPIEEVFSKFKSHVKAYLSERPDLVLATPQGMTKKAHRRSLLLDAARHFMQQIQRLDSAAFDRHRFSFVPAALREDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PYI4</accession>
    <name>A0A9D4PYI4_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_006090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7961247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PYI4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051769"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7961247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="316" mass="35053" checksum="8C65DF4C6C0309EF" modified="2023-05-03" version="1">MSQDPWARVEAQNNRQNNEQTGSGTGPIQPEPPLPPTGTQGELPPQLVQERQMMAPLPNREAPVQQEYPAGATYAPRNPEQMQSALQQSWAPQYGTSTGGYGQSVPVTQYEAEGAMAALVLRQIDESPPQVRLVFALLEQYTGVAGLFALYMIFGYFAQLLCNLVGFAIPAYASTLSQESVCITHEVDEEGIIFLVYCFAPTKPNGSTHIYNKIIRPIFLRHETSVNKLAAEAGAGIRTVLRGPGRIQGWWKTLTRRAPQALNMAAKRKSDGDDKQRNGPTEDDRSDQETKVPRRHNKDERCPVMYLAHERTSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ11</accession>
    <name>A0A9D4PZ11_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HPB52_022679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Rsan-2018</strain>
            <tissue evidence="3">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ11"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038822906" evidence="2">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7957797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="223" mass="23804" checksum="7523C0034B4231C8" modified="2023-05-03" version="1">MIRASLLLLLALGAVAQAFPYAPTYRFRYLKPGGPRPKPPAKPTHKHTPKPGPRLQDAFLTPVVPLSSWFPPPFLPGNDLKPIPVSLVPPTTYIPTPRGGVLAALLPPPTLTPSRGPFPQPAFFRGPPIVLPRLPRPENVTLLSKLSSGPSVTTTVFRAPGGVTATSVQRVEGTSTSLFTESDTVGGKVTTTRKPVVVFPATVGRIGHLPPNVPPVTYLVYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4PZ27</accession>
    <name>A0A9D4PZ27_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_023160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001250">
        <property type="protein sequence ID" value="KAH7957824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4PZ27"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_057559"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF33">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7957824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="88" mass="9641" checksum="153E8F248363A6AD" modified="2023-05-03" version="1">MNEHSSRSHSILTISLASEVHDPDDPNTFIRRQGKLSLVDLAGSEKTKKTRSRGNTFVEANNINKSLLVLGMKLLKYSAFGIGQLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0A2</accession>
    <name>A0A9D4Q0A2_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HPB52_014649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Rsan-2018</strain>
            <tissue evidence="10">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0A2"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056828"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7962147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="623" mass="70420" checksum="BAC7022BC47C5A8E" modified="2023-05-03" version="1">MNLSAFSNENFDSKEWINHAFQAPEAQENKEAYASEVAFKLQLFIQEMNSALEETAQQVQQNLPRVLREVETMQQEAALLKLQMAAVQKDIAKVEQDSSTSMRTLLELDTIKLRMLDANKALREADNWTTLSADVDQVFQSGDMQAITERLVGLQASLEILVDVPDYEQRLQKLESLKNQLEAMLSPLLVQAFTTQSIEAAKSYVRIFSDMRRMPQLLKYYHNCHRNKLVDAWRKIVDSEADDTFLEWLNNFYDVLIASWHSQVTWCSQVFPDPPAVFILSDVVVDAITNLDPSLQFCLEAAMKQQKSSTVYLTEILELKSSSKLDELDSWTMFQYALKCMQTAGEISIQLAAFDKSITANIKTALKQLHIQKSTFDGSDEATEDKKGNILNDHSTLLLPSVMQRSLRDFATQVHLEDFVAFPESMRAIAKLCTEFTKFTFDTVFAEVQRHFSSVPSLKVWSLENPDGVLTTDLPAFSISPMEYITQIGQYLLTIPQHIEPFIVEENEALSTALKHSSLPHVIEGISTDHVADYLLGCVAQATMYTYIDTVMQIEKLTRQASAQLATDISYLCNVLDDLGLPPLESLQHLVALLKCPPEKFAATAVGKPNQLVQTVRMMRGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q0C3</accession>
    <name>A0A9D4Q0C3_RHISA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HPB52_014650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Rsan-2018</strain>
            <tissue evidence="1">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001249">
        <property type="protein sequence ID" value="KAH7962148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q0C3"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7962148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20627" checksum="AF6187C359E9F38C" modified="2023-05-03" version="1">MHDSQATRQVSLLAQRRRLHALLEKTLEELRSDDTDVAIRAADFVLGLFPLLQAPSLRVHYNDIVCAAYKQLVCTNSLVRSKMSELLEMMIALDMRATTELMLFLADEADSMQLAGILTALCKVLRSDMCMKDFPNQQVLSFFEKYLDSRDDNIRSKAIAGALLMDYYFKAASPKPETEDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q3S3</accession>
    <name>A0A9D4Q3S3_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HPB52_001649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Rsan-2018</strain>
            <tissue evidence="7">Larvae</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7967689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q3S3"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_026888"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_051801"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7967689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="372" mass="41172" checksum="3084EC4F1CA8EA92" modified="2023-05-03" version="1">MAIAVSNAFTGVPFLTVNCVSTRLLLTYISRVIGLYVRCIAKNVDRGLRSWSTPDSSRKGKRMFRFPANPGRRRLWLAQVQRDDWEPTSASRICSDHFKDSDYELRRQDGLKKLRPDAVPTVFPVRGVLEQPEPLEMYSSPVLQPWHAHPAATLQSTQPVSDSARAQVLAPPDFSCNPVVALSKIDPSKYQGAVDTLMLAQDTLRHMKMGPTAHWKPSQAGLLISTSVVLSLAEELLSLRGYKYLLTSRLIQDCLENVFSIVRMKKPVPSAYDVKSSLKLICVGQFLHTPKSSSYDSDDGLHLADLLGASLEKSLEEFINDEEHLENLTLDEVSSVECDILAYVGGFLLKTIIKAIGECPPCTAVLLGDGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5T4</accession>
    <name>A0A9D4Q5T4_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HPB52_009103</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G."/>
                <person name="Yang W.F."/>
                <person name="Lam T.T."/>
                <person name="Chang Q.C."/>
                <person name="Ding S.J."/>
                <person name="Wang X.J."/>
                <person name="Zhu J.G."/>
                <person name="Ruan X.D."/>
                <person name="Zhao L."/>
                <person name="Wei J.T."/>
                <person name="Ye R.Z."/>
                <person name="Que T.C."/>
                <person name="Du C.H."/>
                <person name="Zhou Y.H."/>
                <person name="Cheng J.X."/>
                <person name="Dai P.F."/>
                <person name="Guo W.B."/>
                <person name="Han X.H."/>
                <person name="Huang E.J."/>
                <person name="Li L.F."/>
                <person name="Wei W."/>
                <person name="Gao Y.C."/>
                <person name="Liu J.Z."/>
                <person name="Shao H.Z."/>
                <person name="Wang X."/>
                <person name="Wang C.C."/>
                <person name="Yang T.C."/>
                <person name="Huo Q.B."/>
                <person name="Li W."/>
                <person name="Chen H.Y."/>
                <person name="Chen S.E."/>
                <person name="Zhou L.G."/>
                <person name="Ni X.B."/>
                <person name="Tian J.H."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y.S."/>
                <person name="Xia L.Y."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W.C."/>
            </authorList>
            <dbReference type="PubMed" id="32814014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2021-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Sakyi L.B."/>
                <person name="Cui X."/>
                <person name="Yuan T."/>
                <person name="Jiang B."/>
                <person name="Yang W."/>
                <person name="Lam T.T.-Y."/>
                <person name="Chang Q."/>
                <person name="Ding S."/>
                <person name="Wang X."/>
                <person name="Zhu J."/>
                <person name="Ruan X."/>
                <person name="Zhao L."/>
                <person name="Wei J."/>
                <person name="Que T."/>
                <person name="Du C."/>
                <person name="Cheng J."/>
                <person name="Dai P."/>
                <person name="Han X."/>
                <person name="Huang E."/>
                <person name="Gao Y."/>
                <person name="Liu J."/>
                <person name="Shao H."/>
                <person name="Ye R."/>
                <person name="Li L."/>
                <person name="Wei W."/>
                <person name="Wang X."/>
                <person name="Wang C."/>
                <person name="Huo Q."/>
                <person name="Li W."/>
                <person name="Guo W."/>
                <person name="Chen H."/>
                <person name="Chen S."/>
                <person name="Zhou L."/>
                <person name="Zhou L."/>
                <person name="Ni X."/>
                <person name="Tian J."/>
                <person name="Zhou Y."/>
                <person name="Sheng Y."/>
                <person name="Liu T."/>
                <person name="Pan Y."/>
                <person name="Xia L."/>
                <person name="Li J."/>
                <person name="Zhao F."/>
                <person name="Cao W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Rsan-2018</strain>
            <tissue evidence="15">Larvae</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JABSTV010001248">
        <property type="protein sequence ID" value="KAH7968510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9D4Q5T4"/>
    <dbReference type="VEuPathDB" id="VectorBase:RSAN_056759"/>
    <dbReference type="Proteomes" id="UP000821837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7968510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000821837"/>
        </source>
    </evidence>
    <sequence length="498" mass="56408" checksum="406765231EE2F1E5" modified="2023-05-03" version="1">MVCGQTQTNSLPWGGRRSSARGRRLLEVAHKNDLVVLNDGRPTFYQGDRASALDVTMISSCLTRAATWFPDIESHGSDHVHEAALARRRRLLLRFRLAARLCRLKAHEKKPLEKLKELFAESTTGIDRLVVIENRCRFWIFCTVYVVFFVVTVISIGKTLQNHFEYRDIVSISMTEGNSLQLPAVTFCNLNPLRKSAVCSPNTLDMINGTIRNILCDQEGPMVSSMYETTTNPTFGLCYCIFCSNFNASKISYQASNLPVDGLTLVLDIEREEYLRSSSEMGMIVMVHRRGEHVADMHLIDSSCMQRMMERLPAPYKDRCVTMWPAMWQITLVKAVIYFESIIVEKITQVPELSDATTLSNVGGFMGMYLGLSFLVIFEILEIFVRWFIYLYQRRRASVAPQPAEPTASVAAWQRHANKAIQASKDSKGWSKQRSIWDILKDPGVNSAAGGLVALRRPSGAPQYGYFDSSDWKSAADEAFGPFNPLFLHRSFRPRAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-05-03" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9D4Q5T9</accession>
    <name>A0A9D4Q5T9_RHISA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HPB52_008427</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhipicephalus sanguineus</name>
        <name type="common">Brown dog tick</name>
        <name type="synonym">Ixodes sanguineus</name>
        <dbReference type="NCBI Taxonomy" id="34632"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Parasitiformes</taxon>
            <taxon>Ixodida</taxon>
            <taxon>Ixodoidea</taxon>
            <taxon>Ixodidae</taxon>
            <taxon>Rhipicephalinae</taxon>
            <taxon>Rhipicephalus</taxon>
            <taxon>Rhipicephalus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Cell" volume="182" first="1328" last="1340">
            <title>Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.</title>
            <authorList>
                <consortium name="Tick Genome and Microbiome Consortium (TIGMIC)"/>
                <person name="Jia N."/>
                <person name="Wang J."/>
                <person name="Shi W."/>
                <person name="Du L."/>
                <person name="Sun Y."/>
                <person name="Zhan W."/>
                <person name="Jiang J.F."/>
                <person name="Wang Q."/>
                <person name="Zhang B."/>
                <person name="Ji P."/>
                <person name="Bell-Sakyi L."/>
                <person name="Cui X.M."/>
                <person name="Yuan T.T."/>
                <person name="Jiang B.G.
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